CL2008002295A1 - Compuestos derivados de tiazolida sustituidos con alquilsulfonilos; composicion farmaceutica; y uso para el tratamiento de la hepatitis c. - Google Patents
Compuestos derivados de tiazolida sustituidos con alquilsulfonilos; composicion farmaceutica; y uso para el tratamiento de la hepatitis c.Info
- Publication number
- CL2008002295A1 CL2008002295A1 CL2008002295A CL2008002295A CL2008002295A1 CL 2008002295 A1 CL2008002295 A1 CL 2008002295A1 CL 2008002295 A CL2008002295 A CL 2008002295A CL 2008002295 A CL2008002295 A CL 2008002295A CL 2008002295 A1 CL2008002295 A1 CL 2008002295A1
- Authority
- CL
- Chile
- Prior art keywords
- thiazolid
- alkylsulfonyl
- hepatitis
- substituted
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Compuestos derivados de tiazolida sustituidos con alquilsulfonilos; composición farmacéutica; y uso para el tratamiento de la hepatitis C.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95375807P | 2007-08-03 | 2007-08-03 | |
US4695608P | 2008-04-22 | 2008-04-22 | |
US5636908P | 2008-05-27 | 2008-05-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2008002295A1 true CL2008002295A1 (es) | 2009-03-27 |
Family
ID=39791394
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2008002295A CL2008002295A1 (es) | 2007-08-03 | 2008-08-04 | Compuestos derivados de tiazolida sustituidos con alquilsulfonilos; composicion farmaceutica; y uso para el tratamiento de la hepatitis c. |
Country Status (16)
Country | Link |
---|---|
US (2) | US8124632B2 (es) |
EP (1) | EP2178852B9 (es) |
JP (1) | JP5676258B2 (es) |
CN (1) | CN101835765B (es) |
AR (1) | AR068334A1 (es) |
AU (1) | AU2008299781B2 (es) |
BR (1) | BRPI0815057B8 (es) |
CA (1) | CA2695517C (es) |
CL (1) | CL2008002295A1 (es) |
EA (1) | EA019357B1 (es) |
ES (1) | ES2550755T3 (es) |
HK (1) | HK1147094A1 (es) |
MX (1) | MX2010001358A (es) |
PT (1) | PT2178852E (es) |
TW (1) | TWI453018B (es) |
WO (1) | WO2009035788A1 (es) |
Families Citing this family (20)
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CA2752233C (en) | 2009-02-13 | 2017-01-03 | Romark Laboratories L.C. | Controlled release pharmaceutical formulations of nitazoxanide |
EP2408770B1 (en) | 2009-03-20 | 2014-11-05 | University Of Virginia Patent Foundation | Broad spectrum benzothiophene-nitrothiazolide and other antimicrobials |
EP2411007A4 (en) * | 2009-03-27 | 2012-12-05 | Uab Research Foundation | MODULATION OF IRES-MEDIATED TRANSLATION |
MX337460B (es) * | 2009-05-12 | 2016-03-03 | Romark Lab Lc | Compuestos de haloalquil heteroaril benzamida. |
MX341877B (es) | 2009-06-26 | 2016-09-06 | Romark Laboratories L C * | Compuestos y métodos para tratar influenza. |
US9333193B2 (en) | 2010-09-20 | 2016-05-10 | University Of Virginia Patent Foundation | Compositions and methods for treating tuberculosis |
BR112013010738B1 (pt) * | 2010-11-01 | 2020-03-17 | Romark Laboratories L.C | Composto de alquilsulfinil tiazolida |
WO2016077420A1 (en) * | 2014-11-11 | 2016-05-19 | Romark Laboratories, L.C. | Compositions and methods of treatment with prodrugs of tizoxanide, an analogue or salt thereof |
WO2016087265A1 (en) * | 2014-12-01 | 2016-06-09 | Syngenta Participations Ag | Pesticidally active amide heterocyclic derivatives with sulphur containing substituents |
CN105777808B (zh) * | 2014-12-23 | 2018-11-09 | 中国人民解放军军事医学科学院毒物药物研究所 | 替唑尼特磷酸酯和烷基磺酸酯及其在药学中的应用 |
EP3436074B1 (en) | 2016-03-31 | 2020-06-10 | Romark Laboratories, L.C. | Thiazolide compounds for treating viral infections |
JP6894923B2 (ja) | 2016-04-11 | 2021-06-30 | ジェンフィGenfit | 胆汁うっ滞性及び線維性の疾患の処置方法 |
CN106565626B (zh) * | 2016-10-10 | 2022-06-10 | 淮海工学院 | 2-氨基-4-芳基-5-甲硫基噻唑类化合物的合成方法 |
WO2018107332A1 (zh) * | 2016-12-12 | 2018-06-21 | 中山大学 | 一类手性芳杂胺类衍生物及其合成方法和应用 |
CN108610301B (zh) * | 2016-12-12 | 2021-08-31 | 中山大学 | 一类手性芳杂胺类衍生物及其合成方法和应用 |
WO2018195035A1 (en) | 2017-04-18 | 2018-10-25 | Romark Laboratories L.C. | Inhibition of protein disulfide-isomerase a3 |
US11661420B2 (en) * | 2019-04-30 | 2023-05-30 | Nanjing Hepo Pharmaceutical Co., Ltd | Compound containing fused ring, use thereof and pharmaceutical composition containing same |
CN112480104A (zh) * | 2019-09-11 | 2021-03-12 | 北京美倍他药物研究有限公司 | 硝唑尼特衍生物及其医药用途 |
EP4182304A1 (en) | 2020-07-20 | 2023-05-24 | Romark Laboratories, L.C. | Crystalline salts of tizoxanide and 2-hydroxy-n-(5-chloro-1,3-thiazol-2-yl)benzamide (rm-4848) with ethanolamine, morpholine, propanolamine, piperazine and n-methylpiperazine |
CN116367892A (zh) | 2020-08-24 | 2023-06-30 | 罗马克实验室有限公司 | 噻唑化物抗冠状病毒的用途 |
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GB1437800A (en) * | 1973-08-08 | 1976-06-03 | Phavic Sprl | Derivatives of 2-benzamido-5-nitro-thiazoles |
US4337081A (en) | 1979-01-23 | 1982-06-29 | Olin Corporation | 5-Amido-3-trihalomethyl-1,2,4-thiadiazoles and their use as herbicides |
US4343945A (en) | 1979-01-23 | 1982-08-10 | Olin Corporation | 5-Benzamido-3-trichloromethyl-1,2,4-thiadiazoles and their use as herbicides, fungicides and insecticides |
SU910628A1 (ru) | 1980-04-22 | 1982-03-07 | Гродненский государственный медицинский институт | Способ получени 2-ациламинотиазолов |
JPS56158703A (en) | 1980-05-10 | 1981-12-07 | Sankyo Co Ltd | Fungicide |
US4416683A (en) | 1980-09-16 | 1983-11-22 | Eli Lilly And Company | Benzamides, compositions and agricultural method |
JPS619978A (ja) | 1984-06-22 | 1986-01-17 | Nippon Steel Corp | 溶接用フラツクスの循環使用方法 |
US4874864A (en) * | 1988-05-24 | 1989-10-17 | Pfizer Inc. | Benzamide protease inhibitors |
US5169846A (en) * | 1989-10-12 | 1992-12-08 | Crooks Michael J | Non-aqueous micellar solutions of anthelmintic benzimidazoles, closantel, or phenothiazine, and insect growth regulators |
US5578621A (en) * | 1994-09-08 | 1996-11-26 | Romark Lab Lc | Benzamide derivatives |
PT755386E (pt) | 1994-04-13 | 2002-11-29 | Romark Lab Lc | Derivado de benzamida composicoes contendo o referido derivado e sua utilizacao |
MX9604483A (es) * | 1994-09-08 | 1998-02-28 | Jean-Francois Rossignol | Derivados de benzamida, composiciones que contienen dicho derivado y uso de las mismas. |
GB9725298D0 (en) | 1997-11-28 | 1998-01-28 | Zeneca Ltd | Insecticidal thiazole derivatives |
PL199236B1 (pl) * | 1998-07-08 | 2008-08-29 | Sanofi Aventis Deutschland | N-Aryloamidy kwasów sulfonyloaminokarboksylowych podstawionych siarką, sposób ich wytwarzania, środek farmaceutyczny i zastosowanie N-aryloamidów kwasów sulfonyloaminokarboksylowych podstawionych siarką |
GB9823871D0 (en) * | 1998-10-30 | 1998-12-23 | Pharmacia & Upjohn Spa | 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents |
US6849254B1 (en) * | 1999-04-19 | 2005-02-01 | Schering Corporation | HCV combination therapy |
US6136835A (en) * | 1999-05-17 | 2000-10-24 | The Procter & Gamble Company | Methods of treatment for viral infections |
PT1347971E (pt) | 2000-12-21 | 2006-06-30 | Bristol Myers Squibb Co | Inibidores tiazolilicos de tirosina-cinases da familia tec |
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SE0102764D0 (sv) * | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
JP2003335680A (ja) * | 2002-05-21 | 2003-11-25 | Otsuka Pharmaceut Factory Inc | Acat−1阻害剤 |
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TW200711649A (en) | 2005-06-17 | 2007-04-01 | Combinatorx Inc | Combination therapy for the treatment of immunoinflammatory disorders |
BRPI0612287A8 (pt) | 2005-06-27 | 2019-01-22 | Exelixis Inc | composição para uso farmacêutico no tratamento de doenças através da medicina nuclear e métodos de uso e para modulação de atividade de receptor nuclear |
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CN101273023A (zh) * | 2005-08-02 | 2008-09-24 | Irm责任有限公司 | 作为蛋白激酶抑制剂的5-取代的噻唑-2-基氨基化合物和组合物 |
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US7880012B2 (en) | 2006-04-28 | 2011-02-01 | Transtech Pharma, Inc. | Benzamide glucokinase activators |
US20100081713A1 (en) | 2008-03-19 | 2010-04-01 | CombinatoRx, (Singapore) Pte. Ltd. | Compositions and methods for treating viral infections |
US20100009970A1 (en) * | 2008-03-19 | 2010-01-14 | Combinatorx (Singapore) Pte. Ltd. | Compositions and methods for treatment of viral diseases |
EP2408770B1 (en) | 2009-03-20 | 2014-11-05 | University Of Virginia Patent Foundation | Broad spectrum benzothiophene-nitrothiazolide and other antimicrobials |
-
2008
- 2008-08-01 EP EP08830038.9A patent/EP2178852B9/en active Active
- 2008-08-01 JP JP2010519250A patent/JP5676258B2/ja not_active Expired - Fee Related
- 2008-08-01 AU AU2008299781A patent/AU2008299781B2/en not_active Ceased
- 2008-08-01 ES ES08830038.9T patent/ES2550755T3/es active Active
- 2008-08-01 US US12/184,760 patent/US8124632B2/en active Active
- 2008-08-01 MX MX2010001358A patent/MX2010001358A/es active IP Right Grant
- 2008-08-01 CA CA2695517A patent/CA2695517C/en active Active
- 2008-08-01 PT PT88300389T patent/PT2178852E/pt unknown
- 2008-08-01 WO PCT/US2008/071990 patent/WO2009035788A1/en active Application Filing
- 2008-08-01 CN CN2008801098353A patent/CN101835765B/zh active Active
- 2008-08-01 BR BRPI0815057A patent/BRPI0815057B8/pt active IP Right Grant
- 2008-08-01 EA EA201070182A patent/EA019357B1/ru unknown
- 2008-08-04 CL CL2008002295A patent/CL2008002295A1/es unknown
- 2008-08-04 TW TW097129498A patent/TWI453018B/zh not_active IP Right Cessation
- 2008-08-04 AR ARP080103404A patent/AR068334A1/es unknown
-
2011
- 2011-02-02 HK HK11101101.1A patent/HK1147094A1/xx not_active IP Right Cessation
-
2012
- 2012-01-19 US US13/353,686 patent/US8895752B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AR068334A1 (es) | 2009-11-11 |
PT2178852E (pt) | 2015-11-12 |
CA2695517C (en) | 2016-09-20 |
BRPI0815057A2 (pt) | 2015-07-28 |
EP2178852A1 (en) | 2010-04-28 |
BRPI0815057B1 (pt) | 2020-11-10 |
MX2010001358A (es) | 2010-04-09 |
EA019357B1 (ru) | 2014-03-31 |
US8124632B2 (en) | 2012-02-28 |
US20120122939A1 (en) | 2012-05-17 |
AU2008299781A1 (en) | 2009-03-19 |
CN101835765A (zh) | 2010-09-15 |
TW200911239A (en) | 2009-03-16 |
US8895752B2 (en) | 2014-11-25 |
EA201070182A1 (ru) | 2010-10-29 |
US20090036467A1 (en) | 2009-02-05 |
WO2009035788A1 (en) | 2009-03-19 |
JP5676258B2 (ja) | 2015-02-25 |
ES2550755T3 (es) | 2015-11-12 |
CN101835765B (zh) | 2013-05-29 |
HK1147094A1 (en) | 2011-07-29 |
EP2178852B9 (en) | 2016-06-22 |
AU2008299781B2 (en) | 2013-11-14 |
JP2010535712A (ja) | 2010-11-25 |
EP2178852B1 (en) | 2015-07-22 |
TWI453018B (zh) | 2014-09-21 |
BRPI0815057B8 (pt) | 2021-05-25 |
CA2695517A1 (en) | 2009-03-19 |
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