CL2008001745A1 - Compounds derived from imidazo [1,2-a] pyrazine; pharmaceutical composition; and use of the compounds as protein kinase inhibitors in the treatment of cancer. - Google Patents

Compounds derived from imidazo [1,2-a] pyrazine; pharmaceutical composition; and use of the compounds as protein kinase inhibitors in the treatment of cancer.

Info

Publication number
CL2008001745A1
CL2008001745A1 CL2008001745A CL2008001745A CL2008001745A1 CL 2008001745 A1 CL2008001745 A1 CL 2008001745A1 CL 2008001745 A CL2008001745 A CL 2008001745A CL 2008001745 A CL2008001745 A CL 2008001745A CL 2008001745 A1 CL2008001745 A1 CL 2008001745A1
Authority
CL
Chile
Prior art keywords
compounds
imidazo
pyrazine
pharmaceutical composition
cancer
Prior art date
Application number
CL2008001745A
Other languages
Spanish (es)
Inventor
J Tagat
T Yu
D Belanger
A Kerekes
Z Meng
S Esposite
A Mandal
Y Xiao
B Kulkarni
P Curran
R Doll
M Siddiqui
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40002934&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2008001745(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of CL2008001745A1 publication Critical patent/CL2008001745A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Compuestos derivados de imidazo[1,2-a]pirazina; composición farmacéutica; y uso en el tratamiento del cáncer.Compounds derived from imidazo [1,2-a] pyrazine; pharmaceutical composition; and use in cancer treatment.

CL2008001745A 2007-06-14 2008-06-12 Compounds derived from imidazo [1,2-a] pyrazine; pharmaceutical composition; and use of the compounds as protein kinase inhibitors in the treatment of cancer. CL2008001745A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94399907P 2007-06-14 2007-06-14
US98793207P 2007-11-14 2007-11-14

Publications (1)

Publication Number Publication Date
CL2008001745A1 true CL2008001745A1 (en) 2008-12-05

Family

ID=40002934

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2008001745A CL2008001745A1 (en) 2007-06-14 2008-06-12 Compounds derived from imidazo [1,2-a] pyrazine; pharmaceutical composition; and use of the compounds as protein kinase inhibitors in the treatment of cancer.

Country Status (10)

Country Link
EP (1) EP2170892A2 (en)
JP (1) JP2010529195A (en)
CN (1) CN101772500A (en)
AR (1) AR066958A1 (en)
CA (1) CA2690557A1 (en)
CL (1) CL2008001745A1 (en)
MX (1) MX2009013729A (en)
PE (1) PE20090365A1 (en)
TW (1) TW200911811A (en)
WO (1) WO2008156614A2 (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20120034613A (en) 2009-04-16 2012-04-12 센트로 내셔널 드 인베스티가시오네스 온콜로지카스 (씨엔아이오) Imidazopyrazines for use as kinase inhibitors
TW201107329A (en) * 2009-07-30 2011-03-01 Oncotherapy Science Inc Fused imidazole derivative having ttk inhibitory action
WO2011028638A1 (en) 2009-09-04 2011-03-10 Schering Corporation Modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors
AU2010311511B2 (en) 2009-10-30 2014-07-17 Janssen Pharmaceutica Nv Imidazo[1,2-b]pyridazine derivatives and their use as PDE10 inhibitors
AR080754A1 (en) 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv IMIDAZO DERIVATIVES (1,2-A) PIRAZINA AND ITS USE AS PDE10 INHIBITORS
ES2555261T3 (en) * 2010-06-01 2015-12-30 Bayer Intellectual Property Gmbh Imidazopyrazines substituted
US20130288250A1 (en) * 2010-10-20 2013-10-31 Universite Bordeaux Segalen Signatures of clinical outcome in gastro intestinal stromal tumors and method of treatment of gastrointestinal stromal tumors
EP2444084A1 (en) 2010-10-21 2012-04-25 Centro Nacional de Investigaciones Oncológicas (CNIO) Use of PI3K inibitors for the treatment of obesity
WO2012052745A1 (en) 2010-10-21 2012-04-26 Centro Nacional De Investigaciones Oncológicas (Cnio) Combinations of pi3k inhibitors with a second anti -tumor agent
CA2821834A1 (en) * 2010-12-17 2012-06-21 Bayer Intellectual Property Gmbh 6 substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders
US8673905B2 (en) * 2011-03-17 2014-03-18 Hoffmann-La Roche Inc. Imidazo pyrazines
WO2012162365A1 (en) 2011-05-25 2012-11-29 Bristol-Myers Squibb Company Substituted sulfonamides useful as antiapoptotic bcl inhibitors
JP6115962B2 (en) 2011-06-27 2017-04-19 ヤンセン ファーマシューティカ エヌ．ベー． 1-aryl-4-methyl- [1,2,4] triazolo [4,3-a] quinoxaline derivatives
JP6426603B2 (en) 2012-06-26 2018-11-21 ヤンセン ファーマシューティカ エヌ．ベー． A PDE2 inhibitor such as a 1-aryl-4-methyl- [1,2,4] triazolo [4,3-a] -quinoxaline compound and a PDE10 inhibitor for use in the treatment of a neurological or metabolic disorder combination
ES2607184T3 (en) 2012-07-09 2017-03-29 Janssen Pharmaceutica, N.V. Phosphodiesterase 10 enzyme inhibitors
ES2672797T3 (en) 2014-02-13 2018-06-18 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
US9527835B2 (en) 2014-02-13 2016-12-27 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
EP3105218B1 (en) 2014-02-13 2019-09-25 Incyte Corporation Cyclopropylamines as lsd1 inhibitors
RS59534B1 (en) 2014-02-13 2019-12-31 Incyte Corp Cyclopropylamines as lsd1 inhibitors
US9758523B2 (en) 2014-07-10 2017-09-12 Incyte Corporation Triazolopyridines and triazolopyrazines as LSD1 inhibitors
WO2016007731A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Imidazopyridines and imidazopyrazines as lsd1 inhibitors
WO2016007722A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
WO2016007736A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Imidazopyrazines as lsd1 inhibitors
MX2017012699A (en) 2015-04-03 2018-02-09 Incyte Corp Heterocyclic compounds as lsd1 inhibitors.
MA42606A (en) 2015-08-12 2018-06-20 Incyte Corp SALTS OF LSD1 INHIBITOR
CN109414410B (en) 2016-04-22 2022-08-12 因赛特公司 Formulations of LSD1inhibitors
JP2020502070A (en) 2016-11-30 2020-01-23 ケース ウエスタン リザーブ ユニバーシティ Combinations of 15-PGDH inhibitors with corticosteroids and / or TNF inhibitors and uses thereof
US11718589B2 (en) 2017-02-06 2023-08-08 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase
KR102633530B1 (en) * 2017-03-31 2024-02-02 오리진 온콜로지 리미티드 Compounds and compositions for treating blood disorders
CN107954977A (en) * 2017-12-15 2018-04-24 上海鼎雅药物化学科技有限公司 The synthetic method of Raltitrexed intermediate
US10968200B2 (en) 2018-08-31 2021-04-06 Incyte Corporation Salts of an LSD1 inhibitor and processes for preparing the same
CN115702156A (en) * 2021-04-23 2023-02-14 南京明德新药研发有限公司 Pyridine amide compound
WO2023169438A1 (en) * 2022-03-07 2023-09-14 上海凌达生物医药有限公司 Nitrogen-containing heterocyclic cell cycle inhibitor compounds as well as preparation method therefor and use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7576085B2 (en) * 2002-09-23 2009-08-18 Schering Corporation Imidazopyrazines as cyclin dependent kinase inhibitors
NZ563374A (en) * 2002-09-23 2009-06-26 Schering Corp Imidazopyrazines as cyclin dependent kinase inhibitors
MX2007005643A (en) * 2004-11-10 2008-03-13 Cgi Pharmaceuticals Inc Imidazo[1 , 2-a] pyrazin-8-ylamines useful as modulators of kinase activity.
WO2007058942A2 (en) * 2005-11-10 2007-05-24 Schering Corporation Imidazopyrazines as protein kinase inhibitors

Also Published As

Publication number Publication date
MX2009013729A (en) 2010-01-25
PE20090365A1 (en) 2009-04-04
WO2008156614A2 (en) 2008-12-24
CN101772500A (en) 2010-07-07
AR066958A1 (en) 2009-09-23
CA2690557A1 (en) 2008-12-24
WO2008156614A3 (en) 2009-02-12
EP2170892A2 (en) 2010-04-07
TW200911811A (en) 2009-03-16
JP2010529195A (en) 2010-08-26

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