CL2007001920A1 - Uso de compuestos derivados de piperidinas sustituidas para inhibir la proteina hdm2 en un mamifero que necesita de esta inhibicion, para el tratamiento o prevencion de enfermedades tales como carcinoma de colon e higado, y leucemia. - Google Patents
Uso de compuestos derivados de piperidinas sustituidas para inhibir la proteina hdm2 en un mamifero que necesita de esta inhibicion, para el tratamiento o prevencion de enfermedades tales como carcinoma de colon e higado, y leucemia.Info
- Publication number
- CL2007001920A1 CL2007001920A1 CL200701920A CL2007001920A CL2007001920A1 CL 2007001920 A1 CL2007001920 A1 CL 2007001920A1 CL 200701920 A CL200701920 A CL 200701920A CL 2007001920 A CL2007001920 A CL 2007001920A CL 2007001920 A1 CL2007001920 A1 CL 2007001920A1
- Authority
- CL
- Chile
- Prior art keywords
- piperidins
- mammer
- leukemia
- carcinoma
- colon
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81812806P | 2006-06-30 | 2006-06-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2007001920A1 true CL2007001920A1 (es) | 2008-02-22 |
Family
ID=38895102
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL200701920A CL2007001920A1 (es) | 2006-06-30 | 2007-06-29 | Uso de compuestos derivados de piperidinas sustituidas para inhibir la proteina hdm2 en un mamifero que necesita de esta inhibicion, para el tratamiento o prevencion de enfermedades tales como carcinoma de colon e higado, y leucemia. |
Country Status (9)
Country | Link |
---|---|
US (1) | US20080004286A1 (es) |
EP (1) | EP2037919A2 (es) |
JP (1) | JP2009542664A (es) |
CN (1) | CN101511361A (es) |
CA (1) | CA2656393A1 (es) |
CL (1) | CL2007001920A1 (es) |
MX (1) | MX2009000132A (es) |
TW (1) | TWI329110B (es) |
WO (1) | WO2008005266A2 (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9440978B2 (en) | 2007-12-17 | 2016-09-13 | Janssen Pharmaceutica Nv | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1 |
Families Citing this family (35)
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US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
US20080051375A1 (en) * | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent, and compositions containing the same |
WO2008095063A1 (en) | 2007-01-31 | 2008-08-07 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
EP2508531B1 (en) | 2007-03-28 | 2016-10-19 | President and Fellows of Harvard College | Stitched polypeptides |
WO2009009132A1 (en) * | 2007-07-12 | 2009-01-15 | Cougar Biotechnology, Inc. | Use of 17alpha-hydroxylase/c17, 20-lyase inhibitors for the treatment of cancer |
WO2010074724A1 (en) * | 2008-12-22 | 2010-07-01 | Millennium Pharmaceuticals, Inc. | Combination of aurora kinase inhibitors and anti-cd20 antibodies |
TWI471321B (zh) * | 2009-06-08 | 2015-02-01 | Abbott Gmbh & Co Kg | Bcl-2族群抑制劑之口服醫藥劑型 |
JO3434B1 (ar) | 2009-07-31 | 2019-10-20 | Millennium Pharm Inc | مركبات صيدلانية لمعالجة السرطان وامراض واضطرابات اخري |
JP5099731B1 (ja) | 2009-10-14 | 2012-12-19 | メルク・シャープ・アンド・ドーム・コーポレーション | p53活性を増大する置換ピペリジン及びその使用 |
CN102770024A (zh) | 2010-02-19 | 2012-11-07 | 米伦纽姆医药公司 | 4-{[9-氯-7-(2-氟-6-甲氧基苯基)-5h-嘧啶并[5,4-d][2]苯并氮杂卓-2基]氨基}-2-甲氧基苯甲酸钠的结晶形式 |
UA113500C2 (xx) | 2010-10-29 | 2017-02-10 | Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб | |
EP3679934B1 (en) | 2011-04-29 | 2024-06-05 | The Penn State Research Foundation | Small molecule trail gene induction by normal and tumor cells as an anticancer therapy |
WO2012164578A1 (en) * | 2011-06-02 | 2012-12-06 | Hetero Research Foundation | Compositions and methods for preparing immediate release formulations of nilotinib |
AU2012301810B2 (en) * | 2011-08-30 | 2017-06-01 | Trustees Of Tufts College | FAP-activated proteasome inhibitors for treating solid tumors |
AU2012326026B2 (en) | 2011-10-18 | 2017-04-13 | Aileron Therapeutics, Inc. | Peptidomimetic macrocyles |
WO2013062923A1 (en) * | 2011-10-28 | 2013-05-02 | Merck Sharp & Dohme Corp. | MACROCYCLES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF |
US9062071B2 (en) | 2011-12-21 | 2015-06-23 | Merck Sharp & Dohme Corp. | Substituted piperidines as HDM2 inhibitors |
CN112500466B (zh) | 2012-02-15 | 2022-05-03 | 艾瑞朗医疗公司 | 拟肽大环化合物 |
CN102690826B (zh) * | 2012-04-19 | 2014-03-05 | 山西医科大学 | 一种特异性降低人Aurora-A基因表达的shRNA及其应用 |
WO2014024993A1 (ja) * | 2012-08-09 | 2014-02-13 | 国立大学法人京都大学 | ピぺラジン誘導体およびその用途 |
AU2013337388B2 (en) | 2012-11-01 | 2018-08-02 | Aileron Therapeutics, Inc. | Disubstituted amino acids and methods of preparation and use thereof |
ES2707305T3 (es) | 2012-12-20 | 2019-04-03 | Merck Sharp & Dohme | Imidazopiridinas sustituidas como inhibidores de HDM2 |
EP2752191A1 (en) * | 2013-01-07 | 2014-07-09 | Sanofi | Compositions and methods using hdm2 antagonist and mek inhibitor |
EP2976086B1 (en) | 2013-03-22 | 2020-10-14 | Millennium Pharmaceuticals, Inc. | Combination of catalytic mtorc 1/2 inhibitors and selective inhibitors of aurora a kinase |
SG10201902598VA (en) | 2014-09-24 | 2019-04-29 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and formulations thereof |
BR112017005598A2 (pt) | 2014-09-24 | 2017-12-12 | Aileron Therapeutics Inc | macrociclos peptidomiméticos e usos dos mesmos |
WO2016074580A1 (zh) * | 2014-11-14 | 2016-05-19 | 中国科学院上海生命科学研究院 | 一种提高cd4阳性t淋巴细胞存活率和活性的试剂及其应用 |
EP3233077A4 (en) | 2014-12-19 | 2018-08-08 | The Broad Institute Inc. | Dopamine d2 receptor ligands |
WO2016100823A1 (en) | 2014-12-19 | 2016-06-23 | The Broad Institute, Inc. | Dopamine d2 receptor ligands |
KR102595395B1 (ko) | 2015-02-20 | 2023-10-27 | 다이이찌 산쿄 가부시키가이샤 | 암의 병용 치료법 |
WO2016162229A1 (en) | 2015-04-10 | 2016-10-13 | Capsugel Belgium N.V. | Abiraterone acetate lipid formulations |
WO2016200726A1 (en) * | 2015-06-08 | 2016-12-15 | Texas Tech University System | Inhibitors of mci-1 as drugs to overcome resistance to braf inhibitors and mek inhibitors |
US20180028521A1 (en) | 2016-07-29 | 2018-02-01 | Janssen Pharmaceutica Nv | Methods of Treating Prostate Cancer |
US11124498B2 (en) | 2016-11-23 | 2021-09-21 | The Regents Of The University Of California | Compositions and methods for modulating protease activity |
WO2018207154A1 (en) * | 2017-05-12 | 2018-11-15 | The Hong Kong University Of Science And Technology | Heterocyclic compounds as epha4 inhibitors |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6403584B1 (en) * | 2000-06-22 | 2002-06-11 | Merck & Co., Inc. | Substituted nipecotyl derivatives as inhibitors of cell adhesion |
US6916833B2 (en) * | 2003-03-13 | 2005-07-12 | Hoffmann-La Roche Inc. | Substituted piperidines |
US7632920B2 (en) * | 2003-04-10 | 2009-12-15 | Schering Corporation | Soluble, stable form of HDM2, crystalline forms thereof and methods of use thereof |
US20040213264A1 (en) * | 2003-04-25 | 2004-10-28 | Nortel Networks Limited | Service class and destination dominance traffic management |
US7132421B2 (en) * | 2003-06-17 | 2006-11-07 | Hoffmann-La Roche Inc. | CIS-imidazoles |
US7425638B2 (en) * | 2003-06-17 | 2008-09-16 | Hoffmann-La Roche Inc. | Cis-imidazolines |
JP2009542666A (ja) * | 2006-06-30 | 2009-12-03 | シェーリング コーポレイション | P53活性を増加させる置換ピペリジンおよびその使用 |
-
2007
- 2007-06-27 MX MX2009000132A patent/MX2009000132A/es unknown
- 2007-06-27 US US11/769,003 patent/US20080004286A1/en not_active Abandoned
- 2007-06-27 JP JP2009518255A patent/JP2009542664A/ja not_active Withdrawn
- 2007-06-27 WO PCT/US2007/014956 patent/WO2008005266A2/en active Application Filing
- 2007-06-27 CA CA002656393A patent/CA2656393A1/en not_active Abandoned
- 2007-06-27 EP EP07796519A patent/EP2037919A2/en not_active Withdrawn
- 2007-06-27 CN CNA2007800325938A patent/CN101511361A/zh active Pending
- 2007-06-29 TW TW096123840A patent/TWI329110B/zh active
- 2007-06-29 CL CL200701920A patent/CL2007001920A1/es unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9440978B2 (en) | 2007-12-17 | 2016-09-13 | Janssen Pharmaceutica Nv | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1 |
Also Published As
Publication number | Publication date |
---|---|
WO2008005266A2 (en) | 2008-01-10 |
EP2037919A2 (en) | 2009-03-25 |
CA2656393A1 (en) | 2008-01-10 |
WO2008005266A3 (en) | 2008-05-22 |
CN101511361A (zh) | 2009-08-19 |
JP2009542664A (ja) | 2009-12-03 |
US20080004286A1 (en) | 2008-01-03 |
MX2009000132A (es) | 2009-01-26 |
TW200811139A (en) | 2008-03-01 |
TWI329110B (en) | 2010-08-21 |
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