CL2007001090A1 - Compuestos derivados de diazepano, antagonistas de los receptores ccr-2, ccr-5 y ccr-3; procedimiento de preparacion; composicion farmaceutica; compuesto intermediario; y uso del compuesto en el tratamiento de una enfermedad oclusiva de arterias perifericas, isquemia critica de extremidades, angina inestable, apoplejia, entre otras - Google Patents
Compuestos derivados de diazepano, antagonistas de los receptores ccr-2, ccr-5 y ccr-3; procedimiento de preparacion; composicion farmaceutica; compuesto intermediario; y uso del compuesto en el tratamiento de una enfermedad oclusiva de arterias perifericas, isquemia critica de extremidades, angina inestable, apoplejia, entre otrasInfo
- Publication number
- CL2007001090A1 CL2007001090A1 CL2007001090A CL2007001090A CL2007001090A1 CL 2007001090 A1 CL2007001090 A1 CL 2007001090A1 CL 2007001090 A CL2007001090 A CL 2007001090A CL 2007001090 A CL2007001090 A CL 2007001090A CL 2007001090 A1 CL2007001090 A1 CL 2007001090A1
- Authority
- CL
- Chile
- Prior art keywords
- ccr
- compound
- diazepane
- antagonists
- receptors
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 206010002388 Angina unstable Diseases 0.000 title abstract 2
- 102000004497 CCR2 Receptors Human genes 0.000 title abstract 2
- 108010017312 CCR2 Receptors Proteins 0.000 title abstract 2
- 102000004499 CCR3 Receptors Human genes 0.000 title abstract 2
- 108010017316 CCR3 Receptors Proteins 0.000 title abstract 2
- 102000004274 CCR5 Receptors Human genes 0.000 title abstract 2
- 108010017088 CCR5 Receptors Proteins 0.000 title abstract 2
- 208000006011 Stroke Diseases 0.000 title abstract 2
- 208000007814 Unstable Angina Diseases 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title abstract 2
- 210000001367 artery Anatomy 0.000 title abstract 2
- QPMLSUSACCOBDK-UHFFFAOYSA-N diazepane Chemical compound C1CCNNCC1 QPMLSUSACCOBDK-UHFFFAOYSA-N 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 201000004332 intermediate coronary syndrome Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000002093 peripheral effect Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 208000032064 Chronic Limb-Threatening Ischemia Diseases 0.000 title 1
- 206010034576 Peripheral ischaemia Diseases 0.000 title 1
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- 201000002818 limb ischemia Diseases 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
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- Hospice & Palliative Care (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Compuestos derivados de diazepano, antagonistas de los receptores ccr-2, ccr-5 y ccr-3; procedimiento de preparación; composición farmacéutica; y uso para el tratamiento de una enfermedad oclusiva de arterias periféricas, isquemia de extremidades, angina inestable, apoplejía, esclerosis múltiple, enfermedad de Crohn.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06112832 | 2006-04-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2007001090A1 true CL2007001090A1 (es) | 2008-01-11 |
Family
ID=36991297
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2007001090A CL2007001090A1 (es) | 2006-04-20 | 2007-04-18 | Compuestos derivados de diazepano, antagonistas de los receptores ccr-2, ccr-5 y ccr-3; procedimiento de preparacion; composicion farmaceutica; compuesto intermediario; y uso del compuesto en el tratamiento de una enfermedad oclusiva de arterias perifericas, isquemia critica de extremidades, angina inestable, apoplejia, entre otras |
Country Status (19)
Country | Link |
---|---|
US (1) | US7632829B2 (es) |
EP (1) | EP2010506B1 (es) |
JP (1) | JP5016666B2 (es) |
KR (1) | KR101176697B1 (es) |
CN (1) | CN101472904B (es) |
AR (1) | AR060605A1 (es) |
AT (1) | ATE476424T1 (es) |
AU (1) | AU2007242883B2 (es) |
BR (1) | BRPI0710512A2 (es) |
CA (1) | CA2649636A1 (es) |
CL (1) | CL2007001090A1 (es) |
DE (1) | DE602007008222D1 (es) |
ES (1) | ES2348122T3 (es) |
IL (1) | IL194556A0 (es) |
MX (1) | MX2008013468A (es) |
NO (1) | NO20084332L (es) |
RU (1) | RU2439065C2 (es) |
TW (1) | TWI337181B (es) |
WO (1) | WO2007122103A1 (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009133778A1 (ja) * | 2008-04-30 | 2009-11-05 | 住友化学株式会社 | tert-ブチル 3-アミノピペリジン-1-カルボキシレートの製造方法およびその中間体 |
WO2010006938A1 (en) * | 2008-07-16 | 2010-01-21 | F. Hoffmann-La Roche Ag | Novel heterocyclyl compounds for treatment of cardiovascular disease |
WO2010012619A1 (en) * | 2008-07-28 | 2010-02-04 | F. Hoffmann-La Roche Ag | Diazepan and piperazine derivatives modulators of chemokine receptors |
JP5645840B2 (ja) | 2008-12-02 | 2014-12-24 | 株式会社Wave Life Sciences Japan | リン原子修飾核酸の合成方法 |
JP5998326B2 (ja) | 2009-07-06 | 2016-09-28 | ウェイブ ライフ サイエンス リミテッドWave Life Sciences Ltd. | 新規核酸プロドラッグおよびその使用方法 |
US8471004B2 (en) * | 2009-10-07 | 2013-06-25 | Hoffman-La Roche Inc. | Bicyclic compounds |
WO2011149841A1 (en) | 2010-05-25 | 2011-12-01 | Janssen Pharmaceutica Nv | SUBSTITUTED THIAZOLIDINEDIONE INDAZOLES, INDOLES AND BENZOTRIAZOLES AS ESTROGEN-RELATED RECEPTOR-α MODULATORS |
DK2620428T3 (da) * | 2010-09-24 | 2019-07-01 | Wave Life Sciences Ltd | Asymmetrisk hjælpegruppe |
AU2011310592B2 (en) * | 2010-09-29 | 2015-01-22 | Intervet International B.V. | N-heteroaryl compounds |
UA109290C2 (uk) | 2010-10-07 | 2015-08-10 | Спільні кристали і солі інгібіторів ccr3 | |
US8921559B2 (en) * | 2010-12-01 | 2014-12-30 | Janssen Pharmaceutica Nv | 4-substituted-cyclohexylamino-4-piperidinyl-acetamide antagonists of CCR2 |
MX347361B (es) | 2011-07-19 | 2017-04-12 | Wave Life Sciences Ltd | Metodos para la sintesis de acidos nucleicos funcionalizados. |
US8846656B2 (en) | 2011-07-22 | 2014-09-30 | Novartis Ag | Tetrahydropyrido-pyridine and tetrahydropyrido-pyrimidine compounds and use thereof as C5a receptor modulators |
KR102213609B1 (ko) | 2012-07-13 | 2021-02-08 | 웨이브 라이프 사이언시스 리미티드 | 키랄 제어 |
DK2872485T3 (da) | 2012-07-13 | 2021-03-08 | Wave Life Sciences Ltd | Asymmetrisk hjælpegruppe |
WO2014010718A1 (ja) | 2012-07-13 | 2014-01-16 | 株式会社新日本科学 | キラル核酸アジュバント |
EP3095460A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent |
WO2015108048A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
EP3095461A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator |
SG10201912897UA (en) | 2014-01-16 | 2020-02-27 | Wave Life Sciences Ltd | Chiral design |
EP3177616B1 (en) | 2014-08-04 | 2021-02-24 | Sandoz AG | Novel routes of synthesis for the preparation of suvorexant |
CN110963959B (zh) * | 2018-09-30 | 2023-01-24 | 南京药石科技股份有限公司 | 一种合成n-保护及非保护的3-羟基-4,4-二甲基哌啶的制备方法 |
CN111423454B (zh) * | 2020-04-24 | 2021-06-22 | 苏州大学 | 哌嗪类化合物及其在制备趋化因子受体ccr2拮抗剂中的应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2003081937A (ja) | 2001-09-07 | 2003-03-19 | Bayer Ag | ベンゼンスルホンアミド誘導体 |
EP1506041B1 (en) | 2002-05-10 | 2007-10-24 | F. Hoffmann-La Roche Ag | Ibandronic acid for the treatment and prevention of osteoporosis |
PL1608374T3 (pl) * | 2003-03-24 | 2009-08-31 | Axikin Pharmaceuticals Inc | 2-Fenoksy i 2-fenylosulfonoamidowe pochodne o aktywności antagonistycznej w stosunku do CCR3 do leczenia astmy i innych zaburzeń o podłożu zapalnym lub immunologicznym |
CA2521950C (en) | 2003-04-15 | 2009-11-17 | Merck & Co., Inc. | Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors |
CN100384856C (zh) | 2003-04-17 | 2008-04-30 | 麦克公司 | 趋化因子受体活性调节剂杂环基环戊基四氢异喹啉和杂环基环戊基四氢吡啶并吡啶 |
EP1847537A1 (en) | 2006-04-21 | 2007-10-24 | F. Hoffmann-La Roche Ag | Dicarboxamide derivatives |
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- 2007-04-11 RU RU2008145220/04A patent/RU2439065C2/ru not_active IP Right Cessation
- 2007-04-11 ES ES07727958T patent/ES2348122T3/es active Active
- 2007-04-11 AT AT07727958T patent/ATE476424T1/de active
- 2007-04-11 CA CA002649636A patent/CA2649636A1/en not_active Abandoned
- 2007-04-17 TW TW096113471A patent/TWI337181B/zh not_active IP Right Cessation
- 2007-04-18 CL CL2007001090A patent/CL2007001090A1/es unknown
- 2007-04-19 US US11/788,252 patent/US7632829B2/en not_active Expired - Fee Related
- 2007-04-19 AR ARP070101679A patent/AR060605A1/es unknown
-
2008
- 2008-10-06 IL IL194556A patent/IL194556A0/en unknown
- 2008-10-16 NO NO20084332A patent/NO20084332L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ATE476424T1 (de) | 2010-08-15 |
CA2649636A1 (en) | 2007-11-01 |
KR20090008359A (ko) | 2009-01-21 |
IL194556A0 (en) | 2009-08-03 |
JP5016666B2 (ja) | 2012-09-05 |
US20070249589A1 (en) | 2007-10-25 |
CN101472904A (zh) | 2009-07-01 |
CN101472904B (zh) | 2012-06-06 |
WO2007122103A1 (en) | 2007-11-01 |
TW200808744A (en) | 2008-02-16 |
MX2008013468A (es) | 2008-10-30 |
KR101176697B1 (ko) | 2012-08-23 |
AR060605A1 (es) | 2008-07-02 |
RU2008145220A (ru) | 2010-05-27 |
EP2010506B1 (en) | 2010-08-04 |
ES2348122T3 (es) | 2010-11-30 |
BRPI0710512A2 (pt) | 2012-06-05 |
DE602007008222D1 (de) | 2010-09-16 |
NO20084332L (no) | 2008-11-13 |
AU2007242883B2 (en) | 2012-09-27 |
RU2439065C2 (ru) | 2012-01-10 |
US7632829B2 (en) | 2009-12-15 |
AU2007242883A1 (en) | 2007-11-01 |
JP2009534346A (ja) | 2009-09-24 |
EP2010506A1 (en) | 2009-01-07 |
TWI337181B (en) | 2011-02-11 |
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