CL2007000361A1 - A combination comprising an inhibitor of the hepatitis c virus (vhc) arn polymerase and a vhc protease inhibitor; pharmaceutical composition that includes it; and use of the combination to treat disorders associated with vhc. - Google Patents

A combination comprising an inhibitor of the hepatitis c virus (vhc) arn polymerase and a vhc protease inhibitor; pharmaceutical composition that includes it; and use of the combination to treat disorders associated with vhc.

Info

Publication number
CL2007000361A1
CL2007000361A1 CL2007000361A CL2007000361A CL2007000361A1 CL 2007000361 A1 CL2007000361 A1 CL 2007000361A1 CL 2007000361 A CL2007000361 A CL 2007000361A CL 2007000361 A CL2007000361 A CL 2007000361A CL 2007000361 A1 CL2007000361 A1 CL 2007000361A1
Authority
CL
Chile
Prior art keywords
vhc
combination
inhibitor
hepatitis
virus
Prior art date
Application number
CL2007000361A
Other languages
Spanish (es)
Inventor
Bruce A Malcolm
Tong
Emilio Anthony Emini
Michael James Flint
Anita Yee Mei Howe
Stanley Mullen
Robert Orville Ralston
Original Assignee
Wyeth Corp
Schering Corp
Viropharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp, Schering Corp, Viropharma Inc filed Critical Wyeth Corp
Publication of CL2007000361A1 publication Critical patent/CL2007000361A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Abstract

Combinación que comprende un inhibidor de la arn polimerasa del virus de la hepatitis c (vhc) y un inhibidor de la proteasa del vhc; composición farmacéutica que la comprende; y uso de la combinación para tratar trastornos asociados con vhc.A combination comprising an inhibitor of the hepatitis c virus (vhc) arn polymerase and a vhc protease inhibitor; pharmaceutical composition comprising it; and use of the combination to treat disorders associated with vhc.

CL2007000361A 2006-02-09 2007-02-09 A combination comprising an inhibitor of the hepatitis c virus (vhc) arn polymerase and a vhc protease inhibitor; pharmaceutical composition that includes it; and use of the combination to treat disorders associated with vhc. CL2007000361A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77192706P 2006-02-09 2006-02-09
US84178906P 2006-08-30 2006-08-30

Publications (1)

Publication Number Publication Date
CL2007000361A1 true CL2007000361A1 (en) 2008-01-25

Family

ID=38261665

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2007000361A CL2007000361A1 (en) 2006-02-09 2007-02-09 A combination comprising an inhibitor of the hepatitis c virus (vhc) arn polymerase and a vhc protease inhibitor; pharmaceutical composition that includes it; and use of the combination to treat disorders associated with vhc.

Country Status (7)

Country Link
US (1) US20070224167A1 (en)
EP (1) EP1981523A2 (en)
AR (1) AR059430A1 (en)
CL (1) CL2007000361A1 (en)
PE (1) PE20071230A1 (en)
TW (1) TW200808308A (en)
WO (1) WO2007092645A2 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0715714A2 (en) * 2006-08-25 2014-03-11 Wyeth Corp METHODS FOR REDUCING THE EMERGENCY FREQUENCY OF A RESISTANT TREATMENT HEPATITIS C VIRAL INFECTION TO DELAY THE EMERGENCY OF A TREATMENT RESISTANT HEPATITIS C VIRAL INFECTION TO REDUCE THE RESISTANCE LEVEL OF A VIRAL TREATMENT INFECTION TO REDUCE THE EMERGENCY OF AN HCV-796 RESISTANT HEPATITIS C VIRAL INFECTION, TO IDENTIFY AN INDIVIDUAL WITH A REDUCED PROBABILITY TO ANTI-HEPATITIS DIAGNOSTIC OR DIAGNOSTIC DIAGNOSIS MONITORING TREATMENT IN A PATIENT TO MONITOR THE TREATMENT COURSE OF HEPATITIS C VIRAL INFECTION IN A PATIENT TO PROGNOSTIC DEVELOPMENT OF A HEPATITIS C VIRAL INFECTION RESISTANT TO MONITOR THE INFECTION OF A HEPATITIS C PATIENT AND TO DIAGNOSE THE DEVELOPMENT OF A HEPATITIS VIRAL INFECTION OF TREATMENT IN A PATIENT YOU
WO2009021121A2 (en) * 2007-08-08 2009-02-12 Wyeth Identification and characterization of hcv replicon variants with reduced susceptibility to a combination of polymerase and protease inhibitors, and methods related thereto
US8293705B2 (en) 2007-12-21 2012-10-23 Avila Therapeutics, Inc. HCV protease inhibitors and uses thereof
WO2009082701A1 (en) 2007-12-21 2009-07-02 Avila Therapeutics, Inc. Hcv protease inhibitors and uses thereof
CA2709535A1 (en) 2007-12-21 2009-07-02 Avila Therapeutics, Inc. Hcv protease inhibitors and uses thereof
US8309685B2 (en) 2007-12-21 2012-11-13 Celgene Avilomics Research, Inc. HCV protease inhibitors and uses thereof
WO2009101022A1 (en) * 2008-02-14 2009-08-20 F. Hoffmann-La Roche Ag Heterocyclic antiviral compounds
US8188137B2 (en) 2008-08-15 2012-05-29 Avila Therapeutics, Inc. HCV protease inhibitors and uses thereof
WO2010031832A2 (en) * 2008-09-18 2010-03-25 Ortho-Mcneil-Janssen Pharmaceuticals, Inc Synergistic combinations of a macrocyclic inhibitor of hcv and a thiophene-2-carboxylic acid derivative
TW201023858A (en) * 2008-09-18 2010-07-01 Ortho Mcneil Janssen Pharm Synergistic combinations of a macrocyclic inhibitor of HCV and a nucleoside
WO2010117939A1 (en) * 2009-04-06 2010-10-14 Schering Corporation Hcv inhibitor and therapeutic agent combinations
US20120244122A1 (en) 2009-05-28 2012-09-27 Masse Craig E Peptides for the Treatment of HCV Infections
WO2011014882A1 (en) 2009-07-31 2011-02-03 Medtronic, Inc. CONTINUOUS SUBCUTANEOUS ADMINISTRATION OF INTERFERON-α TO HEPATITIS C INFECTED PATIENTS
EA201490836A1 (en) 2011-10-21 2014-11-28 Эббви Инк. COMBINATION TREATMENT (FOR EXAMPLE, WITH ABT-072 OR ABT-333) WITH THE HELP OF DAA FOR USE WHEN TREATING HCV
GB2515941A (en) 2011-10-21 2015-01-07 Abbvie Inc Methods for treating HCV comprising at least two direct acting antiviral agent, ribavirin but not interferon
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
CA3014667A1 (en) 2016-03-04 2017-09-08 The Board Of Trustees Of Leland Stanford Junior University Compositions and methods for muscle regeneration using prostaglandin e2
CN109689063A (en) 2016-04-28 2019-04-26 埃默里大学 Nucleotide containing alkynes and nucleosides therapeutic combination and its associated uses

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2079105C (en) * 1990-04-04 2000-06-13 Michael Houghton Hepatitis c virus protease
US7012066B2 (en) * 2000-07-21 2006-03-14 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus
KR20050065661A (en) * 2002-11-01 2005-06-29 비로파마 인코포레이티드 Benzofuran compounds, compositions and methods for treatment and prophylaxis of hepatitis c viral infections and associated diseases
KR20060120166A (en) * 2003-10-27 2006-11-24 버텍스 파마슈티칼스 인코포레이티드 Hcv ns3-ns4a protease resistance mutants
WO2005067454A2 (en) * 2003-12-23 2005-07-28 Valeant Pharmaceuticals North America Combination therapy for treating hepatitis c virus infection

Also Published As

Publication number Publication date
WO2007092645A2 (en) 2007-08-16
AR059430A1 (en) 2008-04-09
EP1981523A2 (en) 2008-10-22
TW200808308A (en) 2008-02-16
US20070224167A1 (en) 2007-09-27
WO2007092645A3 (en) 2007-10-04
PE20071230A1 (en) 2008-01-16

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