CL2004000804A1 - Procedimiento de preparacion en una sola etapa de n-(n'-glicilo substituida)-2-cianopirrolidina. - Google Patents

Procedimiento de preparacion en una sola etapa de n-(n'-glicilo substituida)-2-cianopirrolidina.

Info

Publication number
CL2004000804A1
CL2004000804A1 CL200400804A CL2004000804A CL2004000804A1 CL 2004000804 A1 CL2004000804 A1 CL 2004000804A1 CL 200400804 A CL200400804 A CL 200400804A CL 2004000804 A CL2004000804 A CL 2004000804A CL 2004000804 A1 CL2004000804 A1 CL 2004000804A1
Authority
CL
Chile
Prior art keywords
cyanopirrolidine
gluclo
substituted
single stage
preparation procedure
Prior art date
Application number
CL200400804A
Other languages
English (en)
Inventor
Frank Sedelmeier Gottf Schafer
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33301223&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2004000804(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0308854A external-priority patent/GB0308854D0/en
Priority claimed from GB0311836A external-priority patent/GB0311836D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CL2004000804A1 publication Critical patent/CL2004000804A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

LA PRESENTE INVENCION SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION DE UNA 2-CIANOPIRROLIDINA N-(N2--GLICILO SUSTITUIDA) QUE COMPRENDE POR LO MENOS: (a)HACER RACCIONAR, EN PRESENCIA DE DIMETILFORMAMIDA, UN COMPUESTO DE LA FORMULA (V).
CL200400804A 2003-04-16 2004-04-15 Procedimiento de preparacion en una sola etapa de n-(n'-glicilo substituida)-2-cianopirrolidina. CL2004000804A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0308854A GB0308854D0 (en) 2003-04-16 2003-04-16 Organic compounds
GB0311836A GB0311836D0 (en) 2003-05-22 2003-05-22 Process for the manufacture of organic compounds

Publications (1)

Publication Number Publication Date
CL2004000804A1 true CL2004000804A1 (es) 2005-02-11

Family

ID=33301223

Family Applications (1)

Application Number Title Priority Date Filing Date
CL200400804A CL2004000804A1 (es) 2003-04-16 2004-04-15 Procedimiento de preparacion en una sola etapa de n-(n'-glicilo substituida)-2-cianopirrolidina.

Country Status (31)

Country Link
US (1) US7375238B2 (es)
EP (1) EP1620396B1 (es)
JP (1) JP4672647B2 (es)
KR (1) KR101192538B1 (es)
AR (1) AR044019A1 (es)
AU (2) AU2004230245B2 (es)
BR (1) BRPI0409471B8 (es)
CA (1) CA2520128C (es)
CL (1) CL2004000804A1 (es)
CO (1) CO5700735A2 (es)
CY (1) CY1116008T1 (es)
DK (1) DK1620396T3 (es)
EC (1) ECSP056093A (es)
ES (1) ES2531084T3 (es)
HK (1) HK1087695A1 (es)
HR (1) HRP20150163T1 (es)
IL (1) IL170887A (es)
IS (1) IS2979B (es)
MA (1) MA27765A1 (es)
MX (1) MXPA05011073A (es)
MY (1) MY139476A (es)
NO (1) NO333251B1 (es)
NZ (1) NZ542899A (es)
PE (2) PE20050021A1 (es)
PL (1) PL1620396T3 (es)
PT (1) PT1620396E (es)
RU (1) RU2369598C2 (es)
SG (1) SG160212A1 (es)
SI (1) SI1620396T1 (es)
TW (1) TWI359135B (es)
WO (1) WO2004092127A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20050021A1 (es) 2003-04-16 2005-03-15 Novartis Ag Procedimiento para la preparacion de 2-cianopirrolidina n-sustituida
RS57561B1 (sr) 2004-01-20 2018-10-31 Novartis Ag Formulacija dobijena direktnom kompresijom i proces za njeno dobijanje
GT200600008A (es) 2005-01-18 2006-08-09 Formulacion de compresion directa y proceso
JP2009503108A (ja) * 2005-08-04 2009-01-29 ノバルティス アクチエンゲゼルシャフト ビルダグリプチン塩
JP5165584B2 (ja) * 2006-11-29 2013-03-21 田辺三菱製薬株式会社 Ｎ−（ｎ’−置換グリシル）−２−シアノピロリジン誘導体の製法
WO2008084383A2 (en) * 2007-01-10 2008-07-17 Medichem, S.A. Process for preparing vildagliptin
CZ2008512A3 (cs) 2008-08-26 2010-03-10 Zentiva, A. S Zpusob prípravy vysoce cistého vildagliptinu
EP2459531B1 (en) * 2009-07-31 2019-09-11 KRKA, D.D., Novo Mesto Granulate comprising vildagliptin and process for its preparation
HUP0900638A2 (en) * 2009-10-07 2011-05-30 Egyt Gyogyszervegyeszeti Gyar Adducts of inorganic salts basea on vildaelitpin applicable for preparation of pharmaceutical compositions
IT1400714B1 (it) 2010-07-06 2013-06-28 Chemelectiva S R L Processo ed intermedi per la preparazione di un principio attivo.
HU231050B1 (hu) 2010-08-19 2020-02-28 Egis Gyógyszergyár Nyrt. Eljárás gyógyszerhatóanyag előállítására
ITMI20112224A1 (it) 2011-12-06 2013-06-07 Chemelectiva S R L Nuovo processo ed intermedi per la sintesi di vildagliptin
IN2012MU01383A (es) * 2012-05-04 2014-02-28
CN103922986B (zh) * 2013-01-16 2017-02-15 上海彩迩文生化科技有限公司 维大列汀及其类似物、中间体及其制备方法和应用
WO2015145467A1 (en) * 2014-03-28 2015-10-01 Laurus Labs Private Limited An improved process for preparing vildagliptin
WO2021234430A1 (en) 2020-05-17 2021-11-25 Lotus International Pte. Ltd. Modified release dosage form comprising vildagliptin and process for manufacturing the same
WO2022003405A1 (en) 2020-07-03 2022-01-06 Savoi Guilherme One-pot process to obtain a pyrrolidine-2-carbonitrile intermediate compound and industrial scale telescopic process to prepare (2s)-1-[n-(3-hydroxyadamantan-1-yl)glycyl]-2-pyrrolidinecarbonitrile (vildagliptin) using same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510369A (en) * 1994-07-22 1996-04-23 Merck & Co., Inc. Pyrrolidine thrombin inhibitors
TW492957B (en) * 1996-11-07 2002-07-01 Novartis Ag N-substituted 2-cyanopyrrolidnes
CO5150173A1 (es) * 1998-12-10 2002-04-29 Novartis Ag Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv
US6380398B2 (en) 2000-01-04 2002-04-30 Novo Nordisk A/S Therapeutically active and selective heterocyclic compounds that are inhibitors of the enzyme DPP-IV
WO2001055105A1 (en) * 2000-01-24 2001-08-02 Novo Nordisk A/S N-substituted 2-cyanopyroles and -pyrrolines which are inhibitors of the enzyme dpp-iv
TW583185B (en) 2000-06-13 2004-04-11 Novartis Ag N-(substituted glycyl)-2-cyanopyrrolidines and pharmaceutical composition for inhibiting dipeptidyl peptidase-IV (DPP-IV) or for the prevention or treatment of diseases or conditions associated with elevated levels of DPP-IV comprising the same
JP2002265439A (ja) * 2001-03-08 2002-09-18 Mitsubishi Pharma Corp シアノピロリジン誘導体およびその医薬用途
PE20050021A1 (es) 2003-04-16 2005-03-15 Novartis Ag Procedimiento para la preparacion de 2-cianopirrolidina n-sustituida

Also Published As

Publication number Publication date
PE20050021A1 (es) 2005-03-15
AU2008202278A1 (en) 2008-11-20
CA2520128C (en) 2012-02-07
DK1620396T3 (en) 2015-02-23
TW200510299A (en) 2005-03-16
BRPI0409471B8 (pt) 2021-05-25
RU2369598C2 (ru) 2009-10-10
BRPI0409471A (pt) 2006-05-02
US7375238B2 (en) 2008-05-20
KR20060003878A (ko) 2006-01-11
TWI359135B (en) 2012-03-01
NZ542899A (en) 2009-02-28
MXPA05011073A (es) 2005-12-12
NO20055226L (no) 2005-11-07
EP1620396A1 (en) 2006-02-01
RU2005135331A (ru) 2006-06-27
PT1620396E (pt) 2015-03-05
WO2004092127A1 (en) 2004-10-28
PL1620396T3 (pl) 2015-05-29
SG160212A1 (en) 2010-04-29
JP2006523645A (ja) 2006-10-19
HRP20150163T1 (en) 2015-03-27
US20060199854A1 (en) 2006-09-07
PE20081293A1 (es) 2008-11-04
AR044019A1 (es) 2005-08-24
NO333251B1 (no) 2013-04-22
EP1620396B1 (en) 2014-12-03
MY139476A (en) 2009-10-30
AU2004230245A1 (en) 2004-10-28
KR101192538B1 (ko) 2012-10-17
IS2979B (is) 2017-09-15
ECSP056093A (es) 2006-03-01
SI1620396T1 (sl) 2015-03-31
CO5700735A2 (es) 2006-11-30
JP4672647B2 (ja) 2011-04-20
HK1087695A1 (en) 2006-10-20
ES2531084T3 (es) 2015-03-10
AU2004230245B2 (en) 2008-02-21
CA2520128A1 (en) 2004-10-28
CY1116008T1 (el) 2017-01-25
BRPI0409471B1 (pt) 2015-11-03
MA27765A1 (fr) 2006-02-01
IS8122A (is) 2005-11-10
IL170887A (en) 2013-06-27

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