CH609332A5 - Process for the preparation of novel 3-aryloxy-3-phenyl-propylamines - Google Patents

Process for the preparation of novel 3-aryloxy-3-phenyl-propylamines

Info

Publication number
CH609332A5
CH609332A5 CH222978A CH222978A CH609332A5 CH 609332 A5 CH609332 A5 CH 609332A5 CH 222978 A CH222978 A CH 222978A CH 222978 A CH222978 A CH 222978A CH 609332 A5 CH609332 A5 CH 609332A5
Authority
CH
Switzerland
Prior art keywords
propylamines
aryloxy
phenyl
novel
preparation
Prior art date
Application number
CH222978A
Inventor
Bryan Barnet Molloy
Klaus Kurt Schmiegel
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/432,379 external-priority patent/US4314081A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Priority claimed from KR1019750000261A external-priority patent/KR800001009B1/en
Publication of CH609332A5 publication Critical patent/CH609332A5/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Amines of the annexed formula <IMAGE> are prepared, in which Ph denotes a benzene ring, R2 independently of one another denotes H or -CH3, R3 and R4 denote halogen, -CF3, C2- to C4-alkyl, C1-C3-alkoxy or C3-C4-alkenyl and n and m denote 0, 1 or 2, by reaction of the corresponding compound which carries a chlorine atom instead of the amino group with NaN3 with subsequent reduction using NaBH4. Acid addition salts with pharmaceutically acceptable acids are optionally prepared by the customary reaction. The compounds I can be used as psychotropic agents, in particular as antidepressants.
CH222978A 1974-01-10 1975-01-07 Process for the preparation of novel 3-aryloxy-3-phenyl-propylamines CH609332A5 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US05/432,379 US4314081A (en) 1974-01-10 1974-01-10 Arloxyphenylpropylamines
CH10275A CH609675A5 (en) 1974-01-10 1975-01-07
KR1019750000261A KR800001009B1 (en) 1975-01-09 1975-01-09 Process for the preparation of aryloxy phenyl-propylamines

Publications (1)

Publication Number Publication Date
CH609332A5 true CH609332A5 (en) 1979-02-28

Family

ID=27171785

Family Applications (2)

Application Number Title Priority Date Filing Date
CH222978A CH609332A5 (en) 1974-01-10 1975-01-07 Process for the preparation of novel 3-aryloxy-3-phenyl-propylamines
CH222878A CH609331A5 (en) 1974-01-10 1975-01-07 Process for the preparation of 3-aryloxy-3-phenyl-propylamines

Family Applications After (1)

Application Number Title Priority Date Filing Date
CH222878A CH609331A5 (en) 1974-01-10 1975-01-07 Process for the preparation of 3-aryloxy-3-phenyl-propylamines

Country Status (1)

Country Link
CH (2) CH609332A5 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK630987D0 (en) * 1987-12-01 1987-12-01 Ferrosan As ARYLOXYPHENYL PROPYLAMINES, THEIR PREPARATION AND USE
DK258389D0 (en) * 1989-05-26 1989-05-26 Ferrosan As ARYLOXYPHENYL PROPYLAMINES, THEIR PREPARATION AND USE

Also Published As

Publication number Publication date
CH609331A5 (en) 1979-02-28

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Legal Events

Date Code Title Description
PL Patent ceased