CH523890A - Procédé pour la préparation de phthalazines - Google Patents

Procédé pour la préparation de phthalazines

Info

Publication number
CH523890A
CH523890A CH661970A CH661970A CH523890A CH 523890 A CH523890 A CH 523890A CH 661970 A CH661970 A CH 661970A CH 661970 A CH661970 A CH 661970A CH 523890 A CH523890 A CH 523890A
Authority
CH
Switzerland
Prior art keywords
phthalazines
preparation
Prior art date
Application number
CH661970A
Other languages
English (en)
Inventor
Ernest Rodway Ronald
George Simmonds Robin
Original Assignee
Aspro Nicholas Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aspro Nicholas Ltd filed Critical Aspro Nicholas Ltd
Publication of CH523890A publication Critical patent/CH523890A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CH661970A 1969-05-03 1970-05-02 Procédé pour la préparation de phthalazines CH523890A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB22679/69A GB1293565A (en) 1969-05-03 1969-05-03 Aminophthalazines and pharmaceutical compositions thereof

Publications (1)

Publication Number Publication Date
CH523890A true CH523890A (fr) 1972-06-15

Family

ID=10183355

Family Applications (1)

Application Number Title Priority Date Filing Date
CH661970A CH523890A (fr) 1969-05-03 1970-05-02 Procédé pour la préparation de phthalazines

Country Status (9)

Country Link
US (1) US3753988A (fr)
JP (1) JPS4839944B1 (fr)
BE (1) BE749824A (fr)
CH (1) CH523890A (fr)
DE (1) DE2021195A1 (fr)
FR (1) FR2043504B1 (fr)
GB (1) GB1293565A (fr)
IE (1) IE33777B1 (fr)
SE (1) SE376916B (fr)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
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IN148482B (fr) 1977-06-03 1981-03-07 Pfizer
US4370328A (en) 1977-11-03 1983-01-25 Pfizer Inc. Cardiac stimulant 1-(3- or 4-substituted piperidino)phthalazines
CA1114379A (fr) * 1977-11-03 1981-12-15 Pfizer Corporation Piperidino-phtalazines
US5001125A (en) * 1984-03-26 1991-03-19 Janssen Pharmaceutica N.V. Anti-virally active pyridazinamines
ATE49205T1 (de) * 1984-09-14 1990-01-15 Asta Pharma Ag Substituierte benzylphthalazinon-derivate.
US4868179A (en) * 1987-04-22 1989-09-19 Cohn Jay N Method of reducing mortality associated with congestive heart failure using hydralazine and isosorbide dinitrate
US5106973A (en) * 1987-11-23 1992-04-21 Janssen Pharmaceutica N.V. Pyridzainamine derivatives
US4963676A (en) * 1988-02-09 1990-10-16 Georgia State University Foundation, Inc. Di-substituted phthalazines
JO1645B1 (en) * 1989-12-26 1991-11-27 شركة جانسين فارماسوتيكا ان. في Pyridazine compounds are antibacterial viruses
EP0449203B1 (fr) * 1990-03-30 1994-12-07 Mitsubishi Chemical Corporation Dérivés de 4-phénylphthalazine
US5100893A (en) * 1990-04-18 1992-03-31 Janssen Pharmaceutica N.V. Antipicornaviral pyridazinamines
TW279162B (fr) * 1991-09-26 1996-06-21 Mitsubishi Chem Corp
CH683965A5 (it) * 1993-02-19 1994-06-30 Limad Marketing Exp & Imp Composti della classe dei ftalidrazidici come sostanza attiva in agenti antinfiammatori ed antitossici.
US5716956A (en) * 1995-06-07 1998-02-10 Bearsden Bearsden Bio, Inc. Dihydrophthalazine antagonists of excitatory amino acid receptors
ATE236134T1 (de) * 1996-12-18 2003-04-15 Neurogen Corp Isoquinolinamin und phtalazinamin derivate, die reagieren mit crf rezeptoren
CO4950519A1 (es) * 1997-02-13 2000-09-01 Novartis Ag Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion
ES2265929T3 (es) 1999-03-30 2007-03-01 Novartis Ag Derivados de ftalazina para el tratamiento de enfermedades inflamatorias.
AR025068A1 (es) * 1999-08-10 2002-11-06 Bayer Corp Pirazinas sustituidas y piridazinas fusionadas, composicion farmaceutica que las comprenden, uso de dichos compuestos para la manufactura de un medicamentocon actividad inhibidora de angiogenesis
US6689883B1 (en) 1999-09-28 2004-02-10 Bayer Pharmaceuticals Corporation Substituted pyridines and pyridazines with angiogenesis inhibiting activity
DOP2000000070A (es) * 1999-09-28 2002-02-28 Bayer Healthcare Llc Piridinas y piridacinas sustituidas con actividad de inhibición de angiogénesis
DE19963607B4 (de) * 1999-12-23 2005-12-15 Schering Ag Verfahren zur Herstellung von 4-(Heteroaryl-methyl) halogen-1(2H)-phthalazinonen
US7977333B2 (en) * 2000-04-20 2011-07-12 Bayer Healthcare Llc Substituted pyridines and pyridazines with angiogenesis inhibiting activity
AR028782A1 (es) * 2000-07-05 2003-05-21 Taisho Pharmaceutical Co Ltd Derivados heterociclicos tetrahidropiridino o piperidino
US6903101B1 (en) 2000-08-10 2005-06-07 Bayer Pharmaceuticals Corporation Substituted pyridazines and fused pyridazines with angiogenesis inhibiting activity
GB0111078D0 (en) * 2001-05-04 2001-06-27 Novartis Ag Organic compounds
US20030236259A1 (en) * 2002-02-05 2003-12-25 Rolf Hohlweg Novel aryl- and heteroarylpiperazines
GB0223341D0 (en) * 2002-10-08 2002-11-13 Groningen Acad Ziekenhuis Organic compounds
GB0310726D0 (en) 2003-05-09 2003-06-11 Merck Sharp & Dohme Therapeutic agents
NZ546990A (en) * 2003-11-20 2010-03-26 Janssen Pharmaceutica Nv 7-Phenylalkyl substituted 2-quinolinones and 2 quinoxalinones as poly(adp-ribose) polymerase inhibitors
SG150533A1 (en) 2003-11-20 2009-03-30 Janssen Pharmaceutica Nv 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2- quinoxalinones as poly(adp-ribose) polymerase inhibitors
UA89618C2 (ru) * 2003-12-05 2010-02-25 Янссен Фармацевтика Н.В. 6-замещенные 2-хинолиноны и 2-хиноксалиноны как ингибиторы поли(адф-рибоза)полимеразы
AU2005260102A1 (en) 2004-05-08 2006-01-12 Novartis International Pharmaceutical Ltd. 3-aryl-5,6-disubstituted pyridazines
WO2005120092A1 (fr) * 2004-06-02 2005-12-15 Ktfreetel Co., Ltd. Systeme de prestation de service applicatif et gestionnaire et modifiant l'interface utilisateur et procede associe
AU2005259189B2 (en) * 2004-06-30 2011-04-21 Janssen Pharmaceutica N.V. Phthalazine derivatives as PARP inhibitors
MXPA06014541A (es) 2004-06-30 2007-03-23 Janssen Pharmaceutica Nv Derivados de quinazolindiona como inhibidores de la poli(adp-ribosa) polimerasa.
CA2568835C (fr) 2004-06-30 2014-05-27 Janssen Pharmaceutica N.V. Derives de quinazolinone en tant qu'inhibiteurs de parp
JP2008506716A (ja) * 2004-07-16 2008-03-06 ニトロメッド インコーポレーティッド 心不全に関連する組成物および方法
US20070020330A1 (en) * 2004-11-24 2007-01-25 Medpointe Healthcare Inc. Compositions comprising azelastine and methods of use thereof
MX2007006233A (es) 2004-11-24 2007-11-23 Medpointe Healthcare Inc Composiciones que comprenden azelastina y metodos de uso de la misma.
US8758816B2 (en) 2004-11-24 2014-06-24 Meda Pharmaceuticals Inc. Compositions comprising azelastine and methods of use thereof
CN103110635A (zh) 2005-07-04 2013-05-22 海波因特制药有限责任公司 组胺h3受体拮抗剂
EP1981868A2 (fr) * 2006-01-27 2008-10-22 Pfizer Products Inc. Composes derives d aminophthalazine
WO2007097951A2 (fr) * 2006-02-17 2007-08-30 Nitromed, Inc. Procédés utilisant des composés d'hydralazine et du dinitrate d'isosorbide ou du mononitrate d'isosorbide
WO2007136626A1 (fr) * 2006-05-16 2007-11-29 Nitromed, Inc. Formulations en doses solides de composés d'hydralazine
EA016026B1 (ru) * 2006-05-29 2012-01-30 ХАЙ ПОЙНТ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи 3-(1,3-бензодиоксол-5-ил)-6-(4-циклопропилпиперазин-1-ил)пиридазин, его соли и сольваты и его применение в качестве антагониста н3 рецептора гистамина
CA2678248C (fr) 2007-03-08 2016-06-28 Janssen Pharmaceutica Nv Derives de quinolinone comme inhibiteurs de parp et de tank
DK2137162T3 (en) * 2007-03-15 2018-11-26 Novartis Ag Organic compounds and their applications
EP2014656A3 (fr) * 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC Nouveaux antagonistes d'hétéocycliques h3
US8404713B2 (en) * 2007-10-26 2013-03-26 Janssen Pharmaceutica Nv Quinolinone derivatives as PARP inhibitors
SI2271626T1 (sl) 2008-03-27 2015-03-31 Janssen Pharmaceutica, N.V. Tetrahidrofenantridinoni in tetrahidrociklopentakinolinoni, kot inhibitorji polimerizacije PARP in tubulina
US8168644B2 (en) * 2008-03-27 2012-05-01 Janssen Pharmaceutica Nv Quinazolinone derivatives as tubulin polymerization inhibitors
NZ588001A (en) * 2008-04-29 2012-06-29 Lilly Co Eli Disubstituted phthalazine hedgehog pathway antagonists
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
PT2364185E (pt) * 2008-11-03 2013-07-24 Lilly Co Eli Ftalazina dissubstituída antagonista da via hedgehog
WO2010056620A1 (fr) * 2008-11-17 2010-05-20 Eli Lilly And Company Pyridazines tétrasubstituées antagonistes de la voie hedgehog
EP2358698B1 (fr) 2008-11-17 2012-09-05 Eli Lilly and Company Pyridazine tétrasubstituée en tant qu' antagoniste de la voie de signalisation hedgehog
WO2016123796A1 (fr) * 2015-02-06 2016-08-11 Abbvie Inc. Phtalazines substituées
WO2018080216A1 (fr) * 2016-10-28 2018-05-03 Daewoong Pharmaceutical Co., Ltd. Dérivé de phénylphtalazine, sa méthode de préparation et composition pharmaceutique le comprenant
US11618751B1 (en) 2022-03-25 2023-04-04 Ventus Therapeutics U.S., Inc. Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives
WO2022165173A1 (fr) * 2021-01-28 2022-08-04 The Scripps Research Institute Composés et leur utilisation pour le traitement de troubles neurodégénératifs, dégénératifs et métaboliques
WO2022253326A1 (fr) * 2021-06-05 2022-12-08 药捷安康(南京)科技股份有限公司 Inhibiteur de l'inflammasome nlrp3 et son utilisation
CA3233482A1 (fr) * 2021-09-30 2023-04-06 Origiant Pharmaceutical Co., Ltd Utilisation pharmaceutique et procede de preparation d'un derive d'heteroaryl-phtalazine substitue

Also Published As

Publication number Publication date
BE749824A (fr) 1970-10-30
FR2043504B1 (fr) 1974-10-11
SE376916B (fr) 1975-06-16
JPS4839944B1 (fr) 1973-11-28
IE33777L (en) 1970-11-03
GB1293565A (en) 1972-10-18
DE2021195A1 (de) 1970-11-12
US3753988A (en) 1973-08-21
FR2043504A1 (fr) 1971-02-19
IE33777B1 (en) 1974-10-30

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Legal Events

Date Code Title Description
PL Patent ceased