CH450398A - Verfahren zur Herstellung von Dibenzocycloheptatrienverbindungen - Google Patents

Verfahren zur Herstellung von Dibenzocycloheptatrienverbindungen

Info

Publication number
CH450398A
CH450398A CH196964A CH196964A CH450398A CH 450398 A CH450398 A CH 450398A CH 196964 A CH196964 A CH 196964A CH 196964 A CH196964 A CH 196964A CH 450398 A CH450398 A CH 450398A
Authority
CH
Switzerland
Prior art keywords
dibenzocycloheptatriene
compounds
preparation
dibenzocycloheptatriene compounds
Prior art date
Application number
CH196964A
Other languages
English (en)
Inventor
Gerald Dr Rey-Bellet
Hans Dr Spiegelberg
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to CH760867A priority Critical patent/CH443281A/de
Priority to CH196964A priority patent/CH450398A/de
Priority to CH1570964A priority patent/CH459990A/de
Priority to CH1472067A priority patent/CH472378A/de
Priority to DE19651518973 priority patent/DE1518973A1/de
Priority to DE19651768856 priority patent/DE1768856A1/de
Priority to DE19651518975 priority patent/DE1518975A1/de
Priority to FR4638A priority patent/FR4025M/fr
Priority to NL6501577A priority patent/NL6501577A/xx
Priority to IL31176A priority patent/IL31176A/xx
Priority to IL22953A priority patent/IL22953A/xx
Priority to IL22954A priority patent/IL22954A/xx
Priority to FR4920A priority patent/FR1428086A/fr
Priority to IL31009A priority patent/IL31009A/xx
Priority to BE659599D priority patent/BE659599A/xx
Priority to GB6593/65A priority patent/GB1077151A/en
Priority to FR5665A priority patent/FR1451254A/fr
Priority to GB12358/66A priority patent/GB1077152A/en
Priority to BE659786D priority patent/BE659786A/xx
Priority to NL656501908A priority patent/NL140843B/xx
Priority to GB6594/65A priority patent/GB1070362A/en
Priority to FR5666A priority patent/FR4241M/fr
Priority to GB16368/66A priority patent/GB1070363A/en
Priority to SE12568/68A priority patent/SE345256B/xx
Priority to SE02028/65A priority patent/SE330161B/xx
Priority to BR167253/65A priority patent/BR6567253D0/pt
Priority to SE2029/65A priority patent/SE321925B/xx
Priority to ES0309456A priority patent/ES309456A1/es
Priority to ES0309847A priority patent/ES309847A1/es
Priority to BR167252/65A priority patent/BR6567252D0/pt
Priority to DK84665AA priority patent/DK124821B/da
Priority to DK84865AA priority patent/DK124607B/da
Publication of CH450398A publication Critical patent/CH450398A/de
Priority to US759499A priority patent/US3631103A/en
Priority to IL31176A priority patent/IL31176A0/xx
Priority to US00164107A priority patent/US3726870A/en
Priority to US322600A priority patent/US3860615A/en
Priority to US00322337A priority patent/US3845093A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/15—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/373—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in doubly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/39—Unsaturated compounds containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/34—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/38—Unsaturated compounds containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/34—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CH196964A 1964-02-18 1964-02-18 Verfahren zur Herstellung von Dibenzocycloheptatrienverbindungen CH450398A (de)

Priority Applications (37)

Application Number Priority Date Filing Date Title
CH760867A CH443281A (de) 1964-02-18 1964-02-18 Verfahren zur Herstellung von Dibenzocycloheptatrienverbindungen
CH196964A CH450398A (de) 1964-02-18 1964-02-18 Verfahren zur Herstellung von Dibenzocycloheptatrienverbindungen
CH1570964A CH459990A (de) 1964-02-18 1964-12-04 Verfahren zur Herstellung von Dibenzocycloheptatrien-Verbindungen
CH1472067A CH472378A (de) 1964-02-18 1964-12-04 Verfahren zur Herstellung von Dibenzocycloheptatrien-Verbindungen
DE19651518973 DE1518973A1 (de) 1964-02-18 1965-01-22 Verfahren zur Herstellung von Dibenzocycloheptatrienverbindungen
DE19651768856 DE1768856A1 (de) 1964-02-18 1965-02-02 Tricyclische Verbindungen
DE19651518975 DE1518975A1 (de) 1964-02-18 1965-02-02 Verfahren zur Herstellung von Dibenzocycloheptatrien- Verbindungen
FR4638A FR4025M (de) 1964-02-18 1965-02-06
NL6501577A NL6501577A (de) 1964-02-18 1965-02-09
IL31176A IL31176A (en) 1964-02-18 1965-02-10 Dibenzocycloheptatriene compounds
IL22953A IL22953A (en) 1964-02-18 1965-02-10 Dibenzocycloheptatriene compounds and their manufacture
IL22954A IL22954A (en) 1964-02-18 1965-02-10 Dibenzocycloheptatriene derivatives and process for the manufacture thereof
FR4920A FR1428086A (fr) 1964-02-18 1965-02-10 Procédé pour la préparation de dérivés de dibenzocycloheptatriène
IL31009A IL31009A (en) 1964-02-18 1965-02-10 Dibenzocycloheptatriene compounds and their preparation
BE659599D BE659599A (de) 1964-02-18 1965-02-11
GB12358/66A GB1077152A (en) 1964-02-18 1965-02-16 Novel dibenzocycloheptatriene derivatives
FR5665A FR1451254A (fr) 1964-02-18 1965-02-16 Procédé pour la préparation de dérivés de dibenzocycloheptatriène
GB6593/65A GB1077151A (en) 1964-02-18 1965-02-16 Novel dibenzocycloheptatriene derivatives and a process for their manufacture
BE659786D BE659786A (de) 1964-02-18 1965-02-16
NL656501908A NL140843B (nl) 1964-02-18 1965-02-16 Werkwijze voor de bereiding van op het zenuwstelsel werkzame preparaten.
GB6594/65A GB1070362A (en) 1964-02-18 1965-02-16 Novel dibenzocycloheptatriene derivatives and a process for their manufacture
FR5666A FR4241M (de) 1964-02-18 1965-02-16
GB16368/66A GB1070363A (en) 1964-02-18 1965-02-16 Novel dibenzo cycloheptatriene derivatives
SE2029/65A SE321925B (de) 1964-02-18 1965-02-17
SE02028/65A SE330161B (de) 1964-02-18 1965-02-17
BR167253/65A BR6567253D0 (pt) 1964-02-18 1965-02-17 Processo para a preparacao de derivados de dibenzociclo-heptatrieno
SE12568/68A SE345256B (de) 1964-02-18 1965-02-17
ES0309456A ES309456A1 (es) 1964-02-18 1965-02-17 Un procedimiento para la fabricacion de derivados de dibenzocicloheptatrieno.
ES0309847A ES309847A1 (es) 1964-02-18 1965-02-17 Procedimiento para la preparacion de derivados de dibenzocicloheptatrieno.
BR167252/65A BR6567252D0 (pt) 1964-02-18 1965-02-17 Processo para a preparacao de derivados de dibenzociclo-heptatrienos
DK84665AA DK124821B (da) 1964-02-18 1965-02-18 Analogifremgangsmåde til fremstilling af i 10-stillingen basisk substituerede dibenzocycloheptatrienforbindelser.
DK84865AA DK124607B (da) 1964-02-18 1965-02-18 Analogifremgangsmåde til fremstilling af i 5- og 10-stillingen substituerede dibenzocycloheptatrienforbindelser.
US759499A US3631103A (en) 1964-02-18 1968-09-12 5-(3'-alkoxy or halo-propylidene)-dibenzo (a d)cyclohepta(1 4 6)triene - 10-carboxylic acid amides
IL31176A IL31176A0 (en) 1964-02-18 1968-11-27 New dibenzocycloheptatriene compounds
US00164107A US3726870A (en) 1964-02-18 1971-07-19 10-carbamoyl-dibenzo(a,d)cyclohepta(1,4,6)trien-5-ones
US322600A US3860615A (en) 1964-02-18 1973-01-10 Tricyclic compounds and processes
US00322337A US3845093A (en) 1964-02-18 1973-01-10 Dibenzo(a,d)cycloheptene-10-carbonitriles

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH196964A CH450398A (de) 1964-02-18 1964-02-18 Verfahren zur Herstellung von Dibenzocycloheptatrienverbindungen
CH1472067A CH472378A (de) 1964-02-18 1964-12-04 Verfahren zur Herstellung von Dibenzocycloheptatrien-Verbindungen
CH1570964A CH459990A (de) 1964-02-18 1964-12-04 Verfahren zur Herstellung von Dibenzocycloheptatrien-Verbindungen

Publications (1)

Publication Number Publication Date
CH450398A true CH450398A (de) 1968-01-31

Family

ID=27173380

Family Applications (4)

Application Number Title Priority Date Filing Date
CH196964A CH450398A (de) 1964-02-18 1964-02-18 Verfahren zur Herstellung von Dibenzocycloheptatrienverbindungen
CH760867A CH443281A (de) 1964-02-18 1964-02-18 Verfahren zur Herstellung von Dibenzocycloheptatrienverbindungen
CH1570964A CH459990A (de) 1964-02-18 1964-12-04 Verfahren zur Herstellung von Dibenzocycloheptatrien-Verbindungen
CH1472067A CH472378A (de) 1964-02-18 1964-12-04 Verfahren zur Herstellung von Dibenzocycloheptatrien-Verbindungen

Family Applications After (3)

Application Number Title Priority Date Filing Date
CH760867A CH443281A (de) 1964-02-18 1964-02-18 Verfahren zur Herstellung von Dibenzocycloheptatrienverbindungen
CH1570964A CH459990A (de) 1964-02-18 1964-12-04 Verfahren zur Herstellung von Dibenzocycloheptatrien-Verbindungen
CH1472067A CH472378A (de) 1964-02-18 1964-12-04 Verfahren zur Herstellung von Dibenzocycloheptatrien-Verbindungen

Country Status (11)

Country Link
US (4) US3631103A (de)
BE (2) BE659599A (de)
BR (2) BR6567253D0 (de)
CH (4) CH450398A (de)
DE (3) DE1518973A1 (de)
DK (2) DK124607B (de)
FR (2) FR1428086A (de)
GB (4) GB1070363A (de)
IL (5) IL31176A (de)
NL (2) NL6501577A (de)
SE (3) SE330161B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3846431A (en) * 1965-01-08 1974-11-05 Spiegelberg H Heterocyclically dibenzo(a,d)cyclohepta(1,4)dien-5-one derivatives
BE794424A (fr) * 1972-01-24 1973-07-23 Science Union & Cie Nouveaux dibenzocycloheptenes, leur procede d'obtention et leur application comme medicament
GB1374366A (en) * 1972-07-21 1974-11-20 Science Union & Cie Propanol derivatives and a process for their preparation
US4011241A (en) * 1975-09-08 1977-03-08 Syntex (U.S.A.) Inc. An intermediate in the preparation of 2-(5H-dibenzo[a,d]cyclophepten-5-on-2-yl)acetic, propionic and butyric acids
US3979430A (en) * 1975-09-08 1976-09-07 Syntex (U.S.A.) Inc. Solvolytic process for the preparation of 2-(5H-dibenzo[a,d]cyclohepten-5-on-2-yl)acetic, propionic and butyric acids
US4054579A (en) * 1975-09-08 1977-10-18 Syntex (U.S.A.) Inc. Intermediates in the process for the preparation of 2-(5H-dibenzo[a,d]cyclohepten-5-on-2-yl)acetic, propionic and butyric acids
US4882351A (en) * 1987-10-14 1989-11-21 Roussel Uclaf Tricyclic compounds
US5659033A (en) * 1995-09-13 1997-08-19 Neurogen Corporation N-aminoalkylfluorenecarboxamides; a new class of dopamine receptor subtype specific ligands
AR015446A1 (es) * 1997-09-19 2001-05-02 Smithkline Beecham Corp Antagonistas de receptores de vitronectina, composicion farmaceutica que los contiene, procedimiento para su preparacion, su uso para la elaboracion de unmedicamento y compuestos intermediarios
US6576643B2 (en) 1997-09-19 2003-06-10 Smithkline Beecham Corporation Vitronectin receptor antagonists

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3478048A (en) * 1965-01-08 1969-11-11 Hoffmann La Roche 2,3;3a,12b - tetrahydro - 8h - dibenzo (3,4;6,7)cyclohept(1,2-d)oxazoles and derivatives

Also Published As

Publication number Publication date
GB1070362A (en) 1967-06-01
NL6501908A (de) 1965-08-19
IL31009A (en) 1969-11-12
CH472378A (de) 1969-05-15
DE1518973A1 (de) 1969-08-21
IL22954A (en) 1969-02-27
US3845093A (en) 1974-10-29
SE345256B (de) 1972-05-23
DK124607B (da) 1972-11-06
FR4241M (de) 1966-06-27
BE659599A (de) 1965-08-11
DE1768856A1 (de) 1971-11-04
IL31176A (en) 1969-05-28
IL22953A (en) 1969-03-27
BR6567252D0 (pt) 1973-08-14
NL6501577A (de) 1965-08-19
SE321925B (de) 1970-03-23
GB1077152A (en) 1967-07-26
IL31176A0 (en) 1969-01-29
DK124821B (da) 1972-11-27
BE659786A (de) 1965-08-17
SE330161B (de) 1970-11-09
NL140843B (nl) 1974-01-15
DE1518975A1 (de) 1969-09-11
GB1077151A (en) 1967-07-26
US3631103A (en) 1971-12-28
US3726870A (en) 1973-04-10
US3860615A (en) 1975-01-14
BR6567253D0 (pt) 1973-09-18
GB1070363A (en) 1967-06-01
CH443281A (de) 1967-09-15
CH459990A (de) 1968-07-31
FR1428086A (fr) 1966-02-11

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