CH263147A - Process for the preparation of folic acid. - Google Patents
Process for the preparation of folic acid.Info
- Publication number
- CH263147A CH263147A CH263147DA CH263147A CH 263147 A CH263147 A CH 263147A CH 263147D A CH263147D A CH 263147DA CH 263147 A CH263147 A CH 263147A
- Authority
- CH
- Switzerland
- Prior art keywords
- folic acid
- preparation
- acid
- parts
- weight
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zur Darstellung von Folsäure. Es wurde gefunden, dass Folsäure gebil det wird, wenn man 2,4,5-Triamino-6-oxy- pyrimidin, Glyzerinaldehyd - ditoluol - sulfo- säureester, p-Amino-benzoyl-1(+)-glutamin- säure und ein Jodid, z. B. Jodkalium, in Lö sung aufeinander einwirken lässt.
Ohne Zusatz von Jodid findet keine Fol- säurebildung statt. Bei der Einwirkung von Jodiden auf Glyzerinaldehyd-ditoluolsulfo- säureester allein bildet sich Aerolein. Es ist daher anzunehmen, dass sich die Reaktion in der Weise abspielt, dass ein aus dem Glyzerin- aldehyd-ditoluolsulfosäureester entstandenes Produkt, entweder a,ss-Dijod-glyzerinaldehyd oder Aerolein,
in statu nascendi mit dem Tri- amino-oxypyrimidin und der Aminobenzoyl- glutaminsäure unter Polsäurebildung zusam mentritt.
Die gemäss vorliegendem Verfahren erhal tenen rohen Reaktionsprodukte enthalten in der Regel 6 bis 10 % Folsäure.
Die Folsäure soll als Arzneimittel verwen det werden.
Beispiel: 0,8 Gewichtsteile 2,4,5-Triamino-6-oxy-pyri- midin, 2,0 Gewichtsteile Ditoluolsulfosäure- ester des Glyzerinaldehyds, 1,4 Gewichtsteile p-Amino-benzoyl-1(+)-glutaminsäure und 40 Gewichtsteile Natriumacetat werden in einem Gemisch von 250 Raumteilen Wasser und 750 Raumteilen Methanol in Wasserstoffatmo sphäre gelöst. Zu der klaren Lösung wird bei 0 bis 50 C auf einmal eine Lösung von 2,5 Gewichtsteilen Jodkalium hinzugegeben.
Die Lösung bleibt 55 Stunden bei 0 bis 50 C ste hen, wird hierauf von einer geringen Menge eines roten Niederschlages abfiltriert und im Vakuum bei<B>300</B> C verdampft. Den Rückstand zieht man mit kaltem Aceton aus und löst ihn hierauf in möglichst wenig Wasser. Bei der Zugabe von Salzsäure bis pH = 3,5 fällt ein Niederschlag aus, dessen Menge etwa 0,5 Ge wichtsteile beträgt und der einen Folsäure- gehalt von 6 bis<B>10%</B> besitzt.
Die weitere Reinigung kann auf bekann tem Wege erfolgen.
Process for the preparation of folic acid. It has been found that folic acid is formed if 2,4,5-triamino-6-oxy-pyrimidine, glyceral aldehyde - ditoluene - sulfonic acid ester, p-amino-benzoyl-1 (+) - glutamic acid and a Iodide, e.g. B. Potassium iodine, in solution can act on each other.
Without the addition of iodide, there is no formation of folic acid. When iodides act on glycerine aldehyde ditoluene sulfoic acid ester alone, aerolein is formed. It can therefore be assumed that the reaction takes place in such a way that a product formed from the glycerol aldehyde ditoluenesulfonic acid ester, either a, ss-diiodoglyceraldehyde or aerolein,
in statu nascendi with the triamino-oxypyrimidine and the aminobenzoylglutamic acid, with the formation of polyacid.
The crude reaction products obtained according to the present process generally contain 6 to 10% folic acid.
Folic acid is said to be used as a medicinal product.
Example: 0.8 parts by weight of 2,4,5-triamino-6-oxy-pyrimidine, 2.0 parts by weight of ditoluenesulfonic acid ester of glycerine aldehyde, 1.4 parts by weight of p-amino-benzoyl-1 (+) - glutamic acid and 40 Parts by weight of sodium acetate are dissolved in a mixture of 250 parts by volume of water and 750 parts by volume of methanol in the hydrogen atmosphere. A solution of 2.5 parts by weight of potassium iodide is added all at once to the clear solution at 0 to 50.degree.
The solution remains at 0 to 50 ° C. for 55 hours, a small amount of a red precipitate is then filtered off and evaporated in vacuo at <B> 300 </B> C. The residue is extracted with cold acetone and then dissolved in as little water as possible. When hydrochloric acid is added to pH = 3.5, a precipitate separates out, the amount of which is around 0.5 parts by weight and a folic acid content of 6 to 10%.
Further purification can be carried out in a known manner.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH263147T | 1948-03-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH263147A true CH263147A (en) | 1949-08-15 |
Family
ID=4474709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH263147D CH263147A (en) | 1948-03-01 | 1948-03-01 | Process for the preparation of folic acid. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH263147A (en) |
-
1948
- 1948-03-01 CH CH263147D patent/CH263147A/en unknown
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