CH138200A - Process for N-alkylation with an aminoalkyl halide. - Google Patents
Process for N-alkylation with an aminoalkyl halide.Info
- Publication number
- CH138200A CH138200A CH138200DA CH138200A CH 138200 A CH138200 A CH 138200A CH 138200D A CH138200D A CH 138200DA CH 138200 A CH138200 A CH 138200A
- Authority
- CH
- Switzerland
- Prior art keywords
- sep
- alkylation
- aminoalkyl halide
- chloropropane
- base
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur N-Allzylierung finit einem Aininoalltyllialogeiiid. Vorliegende Erfindung bezieht sich auf die Darstellung einer monoalkylierten Base. von der Formel:
EMI0001.0007
die als Pharmazeutikum und als Zwischen produkt zu solchem verwendet werden kann.
Die Herstellung geschieht derart, da.B man 8-Aminochinolin auf halogenwasserstoffsau- res a-N-Piperidyl-ss-oxy-y-clilorpropan ein wirken lä.Bt und die durch Alkalien frei gemachte Base reinigt. Die freie Base ist c -in hellgelbes Öl vom Siedepunkt 212-213 C unter 1 mm Druck.
<I>Beispiel:</I> 144 Gewichtsteile 8- Aminochinolin wer den mit 214 Gewichtsteilen chlorwasserstoff- saurem a-N-Piperidyl-,8-oxy-y-chlo.rpropan acht Stunden bei 120-180 C verschmolzen. Die Schmelze wird' in Wasser aufgenommen, mit Pottasche alkalisch gemacht und die freie Base in wenig Äther oder Benzol ge löst.
Nach dem Trocknen über Pottasche wird zur Trennung von überschüssigem 8- Aminochinolin fraktioniert destilliert und dabei die monoa.lkylierte Base als hellgelbes Öl vom Siedepunkt 212-213 C bei 1 mm Druck erhalten.
Process for the N-allzylation finitely with an Aininoalltyllialogeiiid. The present invention relates to the preparation of a monoalkylated base. from the formula:
EMI0001.0007
which can be used as a pharmaceutical and as an intermediate to such.
The production takes place in such a way that 8-aminoquinoline is allowed to act on a-N-piperidyl-ss-oxy-y-chloropropane and the base released by alkalis is purified. The free base is c - in a light yellow oil with a boiling point of 212-213 C under 1 mm pressure.
<I> Example: </I> 144 parts by weight of 8-aminoquinoline are fused to 214 parts by weight of a-N-piperidyl-, 8-oxy-y-chloropropane, hydrogen chloride, at 120-180 ° C. for eight hours. The melt is taken up in water, made alkaline with potash and the free base is dissolved in a little ether or benzene.
After drying over potash, excess 8-aminoquinoline is separated by fractional distillation and the monoalkylated base is obtained as a light yellow oil with a boiling point of 212-213 ° C. at 1 mm pressure.
Claims (1)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE138200X | 1927-01-25 | ||
CH134094T | 1928-01-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
CH138200A true CH138200A (en) | 1930-02-15 |
Family
ID=25712227
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH138200D CH138200A (en) | 1927-01-25 | 1928-01-12 | Process for N-alkylation with an aminoalkyl halide. |
Country Status (1)
Country | Link |
---|---|
CH (1) | CH138200A (en) |
-
1928
- 1928-01-12 CH CH138200D patent/CH138200A/en unknown
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