CH137144A - Process for the preparation of a basic phenol alkyl ether. - Google Patents
Process for the preparation of a basic phenol alkyl ether.Info
- Publication number
- CH137144A CH137144A CH137144DA CH137144A CH 137144 A CH137144 A CH 137144A CH 137144D A CH137144D A CH 137144DA CH 137144 A CH137144 A CH 137144A
- Authority
- CH
- Switzerland
- Prior art keywords
- preparation
- alkyl ether
- methyl ester
- basic phenol
- phenol alkyl
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
Verfahren zur Darstellung eines basischen Plienoialkyläthers. Im Hauptpatent ist ein Verfahren zur Darstellung eines neuen basischen Phenol- allzyläthers (2-. 6-Dim:ethoxy-4,-,allyl-phenyl diäthyla-minoäthyläther) beschrieben.
Es zeigt sieh nun, dass man einen neuen Phenolalkyläther erhält, wenn man 5-Allyl.. o-kresotinsäuremethylester (OH, CH, =<B>2.3)</B> entsprechend dem Verfahren des Haupt patentes mit Diäthylaminoäthylchlorid zum 2- (c)-Diäithyl,aminoärtho@xy)"-8-merthyl-5-.aJ,lyl- benzoesäuremethylester umsetzt.
Das Produkt soll als Lolca.lanä"thetikum Verwendung finden.
<I>Beispiel:</I> 75 Gewichtsteile 5-Allyl-o-kresotinsäure- methvjester (OH, CH, = 2. ä) werden zu sammen mit einer Auflösung von 8 Gewichts teilen Natrium in. 200 Gewichtsteilen Alkohol und 75 Gewichtsteilen Diäthylaminoäthyl- eh1oiid einige Zeit gekocht.
Nach dem Ab,de.- still.ieren des Alkohols nimmt man den Rück- stand in verdünnter :Salzsäure .auf, schüttelt mit Äther aus und versetzt ,die ausgeätherte wäs serige Lösung bis zur alkalischen Reaktion mit Natronlauge. Das dadurch abgeschiedene 0l wird abgetrennt, getrocknet und destil- liert.
Unter 1 mm Druck siedet der so erhal tene 2-(co-Diäthylaminoäthoxy)-ä-methyl-5- ally l-benzoesäuremethylester von 166 bis <B>168'</B> als farblose Flüssigkeit. Das daraus mit Salzsäure dargestellte kristallisierte Salz. schmilzt nach dem Umlö@sen aus Aceton bei <B>1</B>.11 bis 112'.
Der neuen Base kommt die folgende Strukturformel zu:
EMI0001.0058
Process for the preparation of a basic Plienoialkyläthers. The main patent describes a process for the preparation of a new basic phenol allzyl ether (2-. 6-Dim: ethoxy-4, -, allyl-phenyl diethyla-minoethyl ether).
It now shows that a new phenol alkyl ether is obtained if 5-allyl .. o-cresotinic acid methyl ester (OH, CH, = <B> 2.3) </B> according to the process of the main patent with diethylaminoethyl chloride to 2- (c ) -Diethyl, aminoärtho @ xy) "- 8-merthyl-5-.aJ, lylbenzoic acid methyl ester.
The product is said to be used as a cosmetic agent.
<I> Example: </I> 75 parts by weight of 5-allyl-o-cresotinic acid methyester (OH, CH, = 2. ä) are combined with a dissolution of 8 parts by weight of sodium in 200 parts by weight of alcohol and 75 parts by weight of diethylaminoethyl - eh1oiid cooked for some time.
After the alcohol has been removed and de-stilled, the residue is taken up in dilute hydrochloric acid, shaken out with ether and the ethereal aqueous solution is mixed with caustic soda until it has an alkaline reaction. The oil thus separated out is separated off, dried and distilled.
Under 1 mm pressure, the 2- (co-diethylaminoethoxy) -a-methyl-5- allyl-benzoic acid methyl ester of 166 to 168 'obtained in this way boils as a colorless liquid. The crystallized salt prepared therefrom with hydrochloric acid. After dissolving from acetone, it melts at <B> 1 </B> .11 to 112 '.
The new base has the following structural formula:
EMI0001.0058
Claims (1)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE137144X | 1927-04-11 | ||
CH135890T | 1928-04-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
CH137144A true CH137144A (en) | 1929-12-15 |
Family
ID=25712586
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH137144D CH137144A (en) | 1927-04-11 | 1928-04-04 | Process for the preparation of a basic phenol alkyl ether. |
Country Status (1)
Country | Link |
---|---|
CH (1) | CH137144A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2914552A (en) * | 1957-02-21 | 1959-11-24 | Schenley Ind Inc | 2-diloweralkylamino-alkoxy-3-methyl-benzoic acid esters |
-
1928
- 1928-04-04 CH CH137144D patent/CH137144A/en unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2914552A (en) * | 1957-02-21 | 1959-11-24 | Schenley Ind Inc | 2-diloweralkylamino-alkoxy-3-methyl-benzoic acid esters |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CH137144A (en) | Process for the preparation of a basic phenol alkyl ether. | |
CH149007A (en) | Process for the preparation of a halogen-containing basic ether. | |
CH250806A (en) | Process for the preparation of a new oxyhydrophenanthrene derivative. | |
DE899294C (en) | Process for the preparation of a spray composition containing dinitroorthocresol | |
DE897559C (en) | Process for the preparation of diaryldialkylaethylenes | |
DE423031C (en) | Process for the preparation of derivatives of aromatic compounds mercured in the aliphatic side chain | |
CH124869A (en) | Process for the preparation of isopropylpropargylbarbituric acid. | |
AT156171B (en) | Process for the preparation of ether derivatives of 3,5-diiodo-4-oxyacetophenone. | |
CH217133A (en) | Process for the production of a water-soluble, higher molecular weight, α-substituted benzylamine derivative. | |
CH144504A (en) | Process for the preparation of a substituted quinoline carboxylic acid derivative. | |
CH125400A (en) | Process for the preparation of a substituted quinoline carboxylic acid derivative. | |
CH124690A (en) | Process for the preparation of N-B-methoxyethylanthranilic acid-B-piperidinoethyl ester. | |
CH126678A (en) | Process for the preparation of 3,6-diamino-10-methylacridinium cholate. | |
CH222074A (en) | Process for the preparation of a sulfonamide. | |
CH137143A (en) | Process for the preparation of a basic phenol alkyl ether. | |
CH132149A (en) | Process for the preparation of isobutyl-n-propylbarbituric acid. | |
CH124228A (en) | Process for the preparation of a substituted quinoline carboxylic acid derivative. | |
CH139990A (en) | Process for the preparation of 2-chloro-4- (oxyethyl) -amino-1-oxybenzene. | |
CH212411A (en) | Process for the production of a betaine-like condensation product. | |
CH164428A (en) | Process for the preparation of a salt of 2-ethoxy-6.9-diamino-acridine. | |
CH135890A (en) | Process for the preparation of a basic phenol alkyl ether. | |
CH168369A (en) | Process for the preparation of the bismuth salt of an arsenic compound. | |
CH140620A (en) | Process for the preparation of a basic derivative of a substituted quinoline carboxylic acid. | |
CH137676A (en) | Process for the preparation of a basic phenol alkyl ether. | |
CH245679A (en) | Process for the preparation of a 4-chloro-benzenesulfonamide. |