CH135161A - Process for the preparation of isobutylallylbarbituric acid. - Google Patents
Process for the preparation of isobutylallylbarbituric acid.Info
- Publication number
- CH135161A CH135161A CH135161DA CH135161A CH 135161 A CH135161 A CH 135161A CH 135161D A CH135161D A CH 135161DA CH 135161 A CH135161 A CH 135161A
- Authority
- CH
- Switzerland
- Prior art keywords
- acid
- preparation
- isobutylallylbarbituric
- urea
- parts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
- C07D239/62—Barbituric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Darstellung der Isobutylallylbarbitursäure. Isobutyla.llylbarbitursäure wurde bis jetzt durch Allylierung von Isobutylbarbitur- säure gewonnen. Es wurde nun gefunden, dass man diese Verbindung auch durch Kon densation von Isobutylallylmalonester und Harnstoff gewinnen kann.
Beispiel: 69 Teile Natrium werden in 750 Teilen absolutem Alkohol gelöst und mit 65 Tei len Harnstoff versetzt. Sobald sich der Harnstoff gelöst hat, werden 2e57 Teile Iso,- butylallylmalo@nester (Siedepunkt 125 bis 130 C bei 14 mm Hg) zugegeben und die 1VIischung drei Stunden auf 110 bis 115 C erhitzt. Das Reaktionsprodukt wird hierauf in 500 Teilen Wasser aufgenommen, nicht umgesetzter Ester extrahiert, und die Bar- bitursäure durch Ansäuern ausgefällt.
Sie kann durch Umfällen und Kristallisation leicht rein erhalten werden. Schmelz punkt 138 C.
Process for the preparation of isobutylallylbarbituric acid. Isobutylbarbituric acid has hitherto been obtained by allylation of isobutylbarbituric acid. It has now been found that this compound can also be obtained by condensation of isobutylallylmalonic ester and urea.
Example: 69 parts of sodium are dissolved in 750 parts of absolute alcohol and 65 parts of urea are added. As soon as the urea has dissolved, 257 parts of isobutylallylmalonester (boiling point 125 to 130 ° C. at 14 mm Hg) are added and the mixture is heated to 110 to 115 ° C. for three hours. The reaction product is then taken up in 500 parts of water, unconverted ester is extracted, and the barbituric acid is precipitated by acidification.
It can easily be obtained in pure form by reprecipitation and crystallization. Melting point 138 C.
Claims (1)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH132149T | 1927-11-30 | ||
CH135161T | 1927-11-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
CH135161A true CH135161A (en) | 1929-08-31 |
Family
ID=25711809
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH135161D CH135161A (en) | 1927-11-30 | 1927-11-30 | Process for the preparation of isobutylallylbarbituric acid. |
Country Status (1)
Country | Link |
---|---|
CH (1) | CH135161A (en) |
-
1927
- 1927-11-30 CH CH135161D patent/CH135161A/en unknown
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