CH135161A - Process for the preparation of isobutylallylbarbituric acid. - Google Patents

Process for the preparation of isobutylallylbarbituric acid.

Info

Publication number
CH135161A
CH135161A CH135161DA CH135161A CH 135161 A CH135161 A CH 135161A CH 135161D A CH135161D A CH 135161DA CH 135161 A CH135161 A CH 135161A
Authority
CH
Switzerland
Prior art keywords
acid
preparation
isobutylallylbarbituric
urea
parts
Prior art date
Application number
Other languages
German (de)
Inventor
Sandoz Chemische Fabri Vormals
Original Assignee
Chem Fab Vormals Sandoz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chem Fab Vormals Sandoz filed Critical Chem Fab Vormals Sandoz
Publication of CH135161A publication Critical patent/CH135161A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C07D239/62—Barbituric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur     Darstellung    der     Isobutylallylbarbitursäure.            Isobutyla.llylbarbitursäure    wurde bis jetzt  durch     Allylierung    von     Isobutylbarbitur-          säure    gewonnen. Es wurde nun gefunden,  dass man     diese        Verbindung    auch durch Kon  densation von     Isobutylallylmalonester    und  Harnstoff gewinnen kann.  



       Beispiel:     69 Teile Natrium werden in 750 Teilen  absolutem Alkohol gelöst und mit 65 Tei  len Harnstoff versetzt. Sobald sich der  Harnstoff gelöst hat, werden     2e57    Teile     Iso,-          butylallylmalo@nester    (Siedepunkt 125 bis  130   C bei 14 mm     Hg)    zugegeben und die       1VIischung    drei Stunden auf 110 bis 115   C    erhitzt. Das Reaktionsprodukt wird hierauf  in 500 Teilen     Wasser    aufgenommen, nicht  umgesetzter Ester     extrahiert,    und die     Bar-          bitursäure    durch Ansäuern ausgefällt.

   Sie  kann durch Umfällen und Kristallisation  leicht     rein    erhalten werden. Schmelz  punkt 138   C.



  Process for the preparation of isobutylallylbarbituric acid. Isobutylbarbituric acid has hitherto been obtained by allylation of isobutylbarbituric acid. It has now been found that this compound can also be obtained by condensation of isobutylallylmalonic ester and urea.



       Example: 69 parts of sodium are dissolved in 750 parts of absolute alcohol and 65 parts of urea are added. As soon as the urea has dissolved, 257 parts of isobutylallylmalonester (boiling point 125 to 130 ° C. at 14 mm Hg) are added and the mixture is heated to 110 to 115 ° C. for three hours. The reaction product is then taken up in 500 parts of water, unconverted ester is extracted, and the barbituric acid is precipitated by acidification.

   It can easily be obtained in pure form by reprecipitation and crystallization. Melting point 138 C.

Claims (1)

<B>PATENTANSPRUCH</B> Verfahren zur Darstellung der Isohutyl- allylbarbitursäure, dadurch gekennzeichnet, dass man Isobutylallyldialkylmalonester durch Alkalialkoholate mit Harnstoff kon densiert. <B> PATENT CLAIM </B> Process for the preparation of isohutylallylbarbituric acid, characterized in that isobutylallyldialkylmalonic ester is condensed by alkali metal alcoholates with urea.
CH135161D 1927-11-30 1927-11-30 Process for the preparation of isobutylallylbarbituric acid. CH135161A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH132149T 1927-11-30
CH135161T 1927-11-30

Publications (1)

Publication Number Publication Date
CH135161A true CH135161A (en) 1929-08-31

Family

ID=25711809

Family Applications (1)

Application Number Title Priority Date Filing Date
CH135161D CH135161A (en) 1927-11-30 1927-11-30 Process for the preparation of isobutylallylbarbituric acid.

Country Status (1)

Country Link
CH (1) CH135161A (en)

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