CA988089A - Substituted nitroimidazoles useful against tripanosomiasis - Google Patents
Substituted nitroimidazoles useful against tripanosomiasisInfo
- Publication number
- CA988089A CA988089A CA101,320A CA101320A CA988089A CA 988089 A CA988089 A CA 988089A CA 101320 A CA101320 A CA 101320A CA 988089 A CA988089 A CA 988089A
- Authority
- CA
- Canada
- Prior art keywords
- tripanosomiasis
- useful against
- nitroimidazoles
- substituted
- substituted nitroimidazoles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
- C07D233/92—Nitro radicals attached in position 4 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
- C07D233/92—Nitro radicals attached in position 4 or 5
- C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
- C07D233/92—Nitro radicals attached in position 4 or 5
- C07D233/95—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by nitrogen atoms, attached to other ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US130770A | 1970-01-07 | 1970-01-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA988089A true CA988089A (en) | 1976-04-27 |
Family
ID=21695371
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA101,320A Expired CA988089A (en) | 1970-01-07 | 1970-12-22 | Substituted nitroimidazoles useful against tripanosomiasis |
Country Status (11)
Country | Link |
---|---|
US (1) | US3711495A (en) |
JP (1) | JPS511717B1 (en) |
CA (1) | CA988089A (en) |
CH (1) | CH555852A (en) |
DE (1) | DE2100242C2 (en) |
FR (1) | FR2081416B1 (en) |
GB (1) | GB1316221A (en) |
NL (1) | NL7018072A (en) |
OA (1) | OA03554A (en) |
ZA (1) | ZA707997B (en) |
ZM (1) | ZM14570A1 (en) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3915978A (en) * | 1970-01-07 | 1975-10-28 | Merck & Co Inc | Nitroimidazoles |
DE2229248C3 (en) * | 1971-07-30 | 1980-03-27 | Gruppo Lepetit S.P.A., Mailand (Italien) | 5-Iminomethyl-2-nitroimidazoI derivatives and process for their preparation |
US4010176A (en) * | 1972-10-27 | 1977-03-01 | Merck & Co., Inc. | Isoxazole substituted nitroimidazoles |
US4080340A (en) * | 1975-07-30 | 1978-03-21 | Merck & Co., Inc. | Nitroimidazoles |
DE2613167A1 (en) * | 1976-03-27 | 1977-10-06 | Bayer Ag | OXIME CARBAMATES, THE PROCESS FOR THEIR MANUFACTURING AND THEIR USE AS INSECTICIDES, ACARICIDES AND NEMATOCIDES |
US4268674A (en) * | 1977-11-14 | 1981-05-19 | The Dow Chemical Company | Preparation of substituted oxatriazoles |
EP0002344B1 (en) * | 1977-11-30 | 1982-09-15 | Merck & Co. Inc. | Substituted nitroimidazoles, process for their preparation and compositions containing them |
US4144345A (en) * | 1977-11-30 | 1979-03-13 | Merck & Co., Inc. | Dihydroxybenzisoxazolin-3-yl-substituted-5-nitroimidazoles as antibacterials and antiprotozoals |
US4269830A (en) * | 1979-05-17 | 1981-05-26 | Merck & Co., Inc. | Compositions and methods for the treatment of chronic trypanosomiasis infections |
GB2101886B (en) * | 1981-05-22 | 1985-07-31 | Merck & Co Inc | Compositions for the treatment of chronic trypanosomiasis infections |
IE59813B1 (en) * | 1986-05-09 | 1994-04-06 | Warner Lambert Co | Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them |
US4719306A (en) * | 1986-08-27 | 1988-01-12 | Pennwalt Corporation | Substituted 3,5-diphenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidines |
US4769468A (en) * | 1987-04-10 | 1988-09-06 | Penwalt Corporation | 5-(acyloxyalkyl)-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidines |
US4727156A (en) * | 1986-08-27 | 1988-02-23 | Pennwalt Corporation | 3-(Substituted phenyl)-3-(1H-imidazol-1-ylmethyl)-2-methyl-5-{[(substituted phenyl)thio]me}isoxazolidine derivatives |
US4727157A (en) * | 1986-08-27 | 1988-02-23 | Pennwalt Corporation | 3-(Substituted phenyl)-3-(1H-1,2,4-triazol-1-yl)methyl-2-methyl-5-[(substituted phenoxy)methyl]isoxazolidine derivatives |
US4831154A (en) * | 1987-04-10 | 1989-05-16 | Pennwalt Corporation | 5-alkyl(or alkenyl)-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidines |
US4769471A (en) * | 1987-04-10 | 1988-09-06 | Pennwalt Corporation | Substituted 3,5-diphenyl-3-(1H-1,2,4-triazol-1-yl-methyl)-2-methylisoxazolidines |
US4767866A (en) * | 1987-04-10 | 1988-08-30 | Pennwalt Corporation | 3-Phenyl-3-(1H-1,2,4-triazol-1-ylmethyl)-2-methyl-5-alkylisoxazolidines |
US4723021A (en) * | 1986-08-27 | 1988-02-02 | Pennwalt Corporation | Substituted 5-(phenoxyalkyl)-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidines |
US4767867A (en) * | 1987-04-10 | 1988-08-30 | Pennwalt Corporation | 5-(alkoxyalkyl)-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidines |
US4767868A (en) * | 1987-04-10 | 1988-08-30 | Pennwalt Corporation | 3-Phenyl-3-(1H-imidazol-1-ylmethyl)-2-methyl-5-[(phenylamino)methyl]isoxazolidines |
US4769469A (en) * | 1987-04-10 | 1988-09-06 | Pennwalt Corporation | 5-(phenyl or phenoxyalkyl)-3-(2-furanyl)-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidines |
US4769470A (en) * | 1987-10-02 | 1988-09-06 | Pennwalt Corporation | 5-(phenyl or phenoxyalkyl)-3-(2-thienyl)-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidines |
US4777263A (en) * | 1987-10-02 | 1988-10-11 | Pennwalt Corporation | 5-substituted-3-(2-naphthalenyl)-3-((1H-imidazol-1-ylmethyl) or (1H-1,2,4-triazol-1-ylmethyl))-2-methylisoxazolidines |
US4749793A (en) * | 1987-10-02 | 1988-06-07 | Pennwalt Corporation | 5-substituted-3-phenyl-3-[1H-imidazol-1-ylmethyl) or (1H-1,2,4-triazol-1-ylmethyl]-2-benzylisoxazolidines (ir 3011) |
US4785117A (en) * | 1987-10-02 | 1988-11-15 | Pennwalt Corporation | 5,5-disubstituted-3-phenyl-3-phenyl-3-[(1H-imidazol-1-ylmethyl) or (1H-1,2,4-triazol-1-ylmethyl)]-2-methylisoxazolidine derivatives (IR 3012) |
US4777262A (en) * | 1987-10-02 | 1988-10-11 | Pennwalt Corporation | 5-(substituted thiomethyl)-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidine derivatives |
US4777264A (en) * | 1987-10-02 | 1988-10-11 | Pennwalt Corporation | 5-carbonyl derivatives of 3-phenyl-3-(1H-imadazol-1-ylmethyl)-2-methylisoxazolidines and related compounds thereof |
US4754042A (en) * | 1987-10-02 | 1988-06-28 | Pennwalt Corporation | 5-{[naphthyl(or 2-oxo-1,3-benzoxathiol-6-yl)oxy]methyl}-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidines |
US4835283A (en) * | 1988-03-07 | 1989-05-30 | Pennwalt Corporation | 3,5-diphenyl-3-[(1H-imidazol-1-ylmethyl) or (1H-1,2,4-triazol-1-ylmethyl)]-2 |
US6072057A (en) * | 1996-06-06 | 2000-06-06 | Gliatech Inc. | 1H-4(5)-cyclo-substituted imidazole derivatives as histamine H3 receptor agents |
US6329342B1 (en) | 1997-08-19 | 2001-12-11 | Eli Lilly And Company | Treatment of congestive heart failure with growth hormone secretagogues |
AU3180999A (en) * | 1998-02-25 | 1999-09-15 | Pharmacia & Upjohn Company | Substituted aminomethyl isoxazoline derivatives useful as antimicrobials |
US6639076B1 (en) | 1998-08-18 | 2003-10-28 | Eli Lilly And Company | Growth hormone secretagogues |
US6828331B1 (en) | 1999-02-19 | 2004-12-07 | Eli Lilly And Company | Growth hormone secretagogues |
US7125840B2 (en) * | 2001-10-09 | 2006-10-24 | Eli Lilly And Company | Substituted dipeptides as growth hormone secretagogues |
WO2003087069A2 (en) * | 2002-04-09 | 2003-10-23 | Eli Lilly And Company | Dipeptidic growth hormone secretagogues |
US20060167268A1 (en) * | 2002-04-09 | 2006-07-27 | Eli Lilly And Company, Patent Division, | Growth hormone secretagogues |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1162257A (en) * | 1965-09-22 | 1969-08-20 | Danippon Pharmaceutical Co Ltd | 3-(5-Nitro-2-Furyl) Isoxazole Derivatives and methods of preparation thereof |
US3472857A (en) * | 1966-02-03 | 1969-10-14 | Ciba Ltd | N-(3-pyrazolyl-propyl)-n'-phenyl piperazines |
US3452035A (en) * | 1966-12-23 | 1969-06-24 | American Cyanamid Co | 2 - amino - 5 - (5 - nitro - 1 - substituted-2 - imidazolyl) - 1,3,4 - thiadiazoles and oxadiazoles |
-
1970
- 1970-01-07 US US00001307A patent/US3711495A/en not_active Expired - Lifetime
- 1970-11-25 ZA ZA707997A patent/ZA707997B/en unknown
- 1970-12-10 NL NL7018072A patent/NL7018072A/xx not_active Application Discontinuation
- 1970-12-21 ZM ZM145/70A patent/ZM14570A1/en unknown
- 1970-12-22 CA CA101,320A patent/CA988089A/en not_active Expired
- 1970-12-29 JP JP45121881A patent/JPS511717B1/ja active Pending
-
1971
- 1971-01-05 DE DE2100242A patent/DE2100242C2/en not_active Expired
- 1971-01-06 GB GB66771A patent/GB1316221A/en not_active Expired
- 1971-01-06 FR FR7100206A patent/FR2081416B1/fr not_active Expired
- 1971-01-07 OA OA54134A patent/OA03554A/en unknown
- 1971-01-07 CH CH21171A patent/CH555852A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JPS511717B1 (en) | 1976-01-20 |
US3711495A (en) | 1973-01-16 |
ZA707997B (en) | 1972-07-26 |
CH555852A (en) | 1974-11-15 |
NL7018072A (en) | 1971-07-09 |
DE2100242A1 (en) | 1971-07-15 |
DE2100242C2 (en) | 1984-07-19 |
FR2081416A1 (en) | 1971-12-03 |
GB1316221A (en) | 1973-05-09 |
FR2081416B1 (en) | 1974-09-27 |
OA03554A (en) | 1971-03-30 |
ZM14570A1 (en) | 1972-08-21 |
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