CA975755A - Nitric acid esters of 21-alcohols belonging to the pregnane series as well as a process for the preparation thereof - Google Patents

Nitric acid esters of 21-alcohols belonging to the pregnane series as well as a process for the preparation thereof

Info

Publication number: CA975755A
Authority: CA; Canada
Prior art keywords: preparation; well; acid esters; nitric acid; pregnane series
Prior art date: 1971-05-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA141,366A

Other versions

CA141366S (en

Inventor

Jozsef Toth

Sandor Holly

Eva Czajlik

Tamas Szen

Anna Boor

Katalin Gorgenyi

Mate Kovatsits

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Richter Gedeon Vegyeszeti Gyar Nyrt

Original Assignee

Richter Gedeon Vegyeszeti Gyar RT

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1971-05-07

Filing date

1972-05-05

Publication date

1975-10-07

1972-05-05 Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT

1975-10-07 Application granted granted Critical

1975-10-07 Publication of CA975755A publication Critical patent/CA975755A/en

Status Expired legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0015—Oxiranes at position 9(11)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CA141,366A 1971-05-07 1972-05-05 Nitric acid esters of 21-alcohols belonging to the pregnane series as well as a process for the preparation thereof Expired CA975755A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HURI429A HU164115B (en)	1971-05-07	1971-05-07

Publications (1)

Publication Number	Publication Date
CA975755A true CA975755A (en)	1975-10-07

Family

ID=11000864

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA141,366A Expired CA975755A (en)	1971-05-07	1972-05-05	Nitric acid esters of 21-alcohols belonging to the pregnane series as well as a process for the preparation thereof

Country Status (15)

Country	Link
JP (1)	JPS5330707B1 (en)
AT (1)	AT316767B (en)
AU (1)	AU469581B2 (en)
CA (1)	CA975755A (en)
CS (2)	CS171259B2 (en)
DD (1)	DD98668A5 (en)
DE (1)	DE2222491C3 (en)
ES (1)	ES402230A1 (en)
FR (1)	FR2143664A1 (en)
HU (1)	HU164115B (en)
NL (1)	NL7206134A (en)
PL (1)	PL75494B1 (en)
SE (2)	SE385590B (en)
SU (1)	SU493963A3 (en)
YU (1)	YU34701B (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5707984A (en) *	1995-12-08	1998-01-13	G. D. Searle & Co.	Steroid nitrite/nitrate ester derivatives useful as anti-inflammatory drugs
US5792758A (en) *	1995-12-08	1998-08-11	G. D. Searle & Co.	Steroid nitrite ester derivatives useful as anti-inflammatory drugs
US5824669A (en) *	1996-03-22	1998-10-20	Nitromed, Inc.	Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
US5837698A (en) *	1996-05-02	1998-11-17	G. D. Searle & Co.	Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
US8207151B2 (en)	2008-05-28	2012-06-26	Validus Biopharma Inc.	Non-hormonal steroid modulators of NF-κB for treatment of disease
US9198921B2 (en)	2010-04-05	2015-12-01	Reveragen Biopharma, Inc.	Non-hormonal steroid modulators of NF-κB for treatment of disease
US10799514B2 (en)	2015-06-29	2020-10-13	Reveragen Biopharma, Inc.	Non-hormonal steroid modulators of NF-kappa beta for treatment of disease
US11382922B2 (en)	2019-03-07	2022-07-12	Reveragen Biopharma, Inc.	Aqueous oral pharmaceutical suspension compositions

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5985862A (en) *	1996-05-02	1999-11-16	G.D. Searle & Co.	Pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs
IT1285770B1 (en)	1996-10-04	1998-06-18	Nicox Sa	CORTICOID COMPOUNDS
ITMI20020148A1 (en)	2002-01-29	2003-07-29	Nicox Sa	NEW CORTICOSTEROIDS
EP2118120B1 (en)	2007-02-05	2016-10-05	Nicox S.A.	Nitric oxide releasing steroids
US8716268B2 (en)	2010-06-07	2014-05-06	Chao Liu	Nitrate esters of corticoid compounds useful as diuretics

1971
- 1971-05-07 HU HURI429A patent/HU164115B/hu unknown
1972
- 1972-04-20 AT AT345872A patent/AT316767B/en not_active IP Right Cessation
- 1972-04-22 ES ES402230A patent/ES402230A1/en not_active Expired
- 1972-04-26 YU YU1117/72A patent/YU34701B/en unknown
- 1972-04-28 DD DD162651A patent/DD98668A5/xx unknown
- 1972-05-01 AU AU41722/72A patent/AU469581B2/en not_active Expired
- 1972-05-04 JP JP4376772A patent/JPS5330707B1/ja active Pending
- 1972-05-04 FR FR7215938A patent/FR2143664A1/en active Granted
- 1972-05-05 SE SE7205915A patent/SE385590B/en unknown
- 1972-05-05 CS CS2266*[A patent/CS171259B2/cs unknown
- 1972-05-05 CS CS3050A patent/CS171258B2/cs unknown
- 1972-05-05 PL PL15518272A patent/PL75494B1/pl unknown
- 1972-05-05 NL NL7206134A patent/NL7206134A/xx not_active Application Discontinuation
- 1972-05-05 SU SU1783400A patent/SU493963A3/en active
- 1972-05-05 CA CA141,366A patent/CA975755A/en not_active Expired
- 1972-05-08 DE DE2222491A patent/DE2222491C3/en not_active Expired
1975
- 1975-03-21 SE SE7503290A patent/SE7503290L/xx unknown

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5707984A (en) *	1995-12-08	1998-01-13	G. D. Searle & Co.	Steroid nitrite/nitrate ester derivatives useful as anti-inflammatory drugs
US5792758A (en) *	1995-12-08	1998-08-11	G. D. Searle & Co.	Steroid nitrite ester derivatives useful as anti-inflammatory drugs
US5824669A (en) *	1996-03-22	1998-10-20	Nitromed, Inc.	Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
US6197762B1 (en)	1996-03-22	2001-03-06	Nitromed, Inc.	Nitrosated and nitrosylated steroids compositions, and methods for treating respiratory disorders
USRE37116E1 (en) *	1996-03-22	2001-03-27	Nitromed, Inc.	Nitrosated and nitrosylated compounds, and compositions and their use for treating respiratory disorders
US6579863B1 (en)	1996-03-22	2003-06-17	Nitromed, Inc.	Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
US7160920B2 (en)	1996-03-22	2007-01-09	Nitromed, Inc.	Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
US7345037B2 (en)	1996-03-22	2008-03-18	Nitromed, Inc.	Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
US5837698A (en) *	1996-05-02	1998-11-17	G. D. Searle & Co.	Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
US8334279B2 (en)	2008-05-28	2012-12-18	Validus Genetics	Non-hormonal steroid modulators of NF-κB for treatment of disease
US10206933B2 (en)	2008-05-28	2019-02-19	Reveragen Biopharma, Inc.	Non-hormonal steroid modulators of NF-kB for treatment of disease
US8673887B2 (en)	2008-05-28	2014-03-18	Reveragen Biopharma, Inc	Non-hormonal steroid modulators of NF-kB for treatment of disease
US11833159B2 (en)	2008-05-28	2023-12-05	Reveragen Biopharma, Inc.	Non-hormonal steroid modulators of NF-kB for treatment of disease
US9434758B2 (en)	2008-05-28	2016-09-06	Reveragen Biopharma, Inc.	Non-hormonal steroid modulators of NF-κB for treatment of disease
US9649320B2 (en)	2008-05-28	2017-05-16	Reveragen Biopharma, Inc.	Non-hormonal steroid modulators of NF-κB for treatment of disease
US10857161B2 (en)	2008-05-28	2020-12-08	Reveragen Biopharma, Inc.	Non-hormonal steroid modulators of NF-kB for treatment of disease
US8207151B2 (en)	2008-05-28	2012-06-26	Validus Biopharma Inc.	Non-hormonal steroid modulators of NF-κB for treatment of disease
US10000525B2 (en)	2010-04-05	2018-06-19	Reveragen Biopharma, Inc.	Non-hormonal steroid modulators of NF-κB for treatment of disease
US9198921B2 (en)	2010-04-05	2015-12-01	Reveragen Biopharma, Inc.	Non-hormonal steroid modulators of NF-κB for treatment of disease
US10799514B2 (en)	2015-06-29	2020-10-13	Reveragen Biopharma, Inc.	Non-hormonal steroid modulators of NF-kappa beta for treatment of disease
US11690853B2 (en)	2015-06-29	2023-07-04	Reveragen Biopharma, Inc.	Non-hormonal steroid modulators of NF-κβ for treatment of disease
US11382922B2 (en)	2019-03-07	2022-07-12	Reveragen Biopharma, Inc.	Aqueous oral pharmaceutical suspension compositions
US11471471B2 (en)	2019-03-07	2022-10-18	Reveragen Biopharma, Inc.	Aqueous oral pharmaceutical suspension compositions

Also Published As

Publication number	Publication date
AU469581B2 (en)	1976-02-19
SU493963A3 (en)	1975-11-28
SE385590B (en)	1976-07-12
NL7206134A (en)	1972-11-09
DE2222491A1 (en)	1972-11-16
YU111772A (en)	1979-07-10
JPS5330707B1 (en)	1978-08-29
CS171259B2 (en)	1976-10-29
FR2143664A1 (en)	1973-02-09
ES402230A1 (en)	1975-03-16
YU34701B (en)	1979-12-31
CS171258B2 (en)	1976-10-29
AT316767B (en)	1974-07-25
DE2222491B2 (en)	1977-09-29
HU164115B (en)	1973-12-28
AU4172272A (en)	1973-11-08
PL75494B1 (en)	1974-12-31
FR2143664B1 (en)	1976-07-02
SE7503290L (en)	1975-03-21
DD98668A5 (en)	1973-07-05
DE2222491C3 (en)	1978-05-03

Publication	Publication Date	Title
AU470423B2 (en)	1973-08-02	Process for preparing acid esters 4-piperidinol derivatives and their use as stabilizers
CA923139A (en)	1973-03-20	Process for the preparation of esters of the carbonic acid
CA1031785A (en)	1978-05-23	Process for the preparation of carbonic acid esters
CA965100A (en)	1975-03-25	Process for the preparation of acrylic acid
CA1035775A (en)	1978-08-01	Process for preparing vincaminic acid esters
CA975755A (en)	1975-10-07	Nitric acid esters of 21-alcohols belonging to the pregnane series as well as a process for the preparation thereof
GB1407932A (en)	1975-10-01	Process for preparing esters of omega-amino-dodecanoic acid
CA1001629A (en)	1976-12-14	Process for making new esters from 2-alcoylthiazozol 5-carboxilic acid
EG11933A (en)	1979-06-30	Process for preparing of novel cyclopropancarboxylic acid esters
CA963912A (en)	1975-03-04	Process for the manufacture of dialkyl-phosphinic acid esters
CA983038A (en)	1976-02-03	Aminothiophene-carboxylic acid esters and process for their preparation
AU3529071A (en)	1973-05-10	Novel amidothionophsphonic acid esters a process for their preparation and their use as herbicides
CA1010899A (en)	1977-05-24	Process for the preparation of 3-keto-glutaric acid by carboxylation of acetone in glime
CA969927A (en)	1975-06-24	Process for the acidolysis of nitric acid esters of steroid-21-alcohols
IL36979A0 (en)	1971-08-25	Process for the preparation of 7-flavonoxyacetic acid lower alkyl esters
CA984403A (en)	1976-02-24	Process for the preparation of multifunctional peroxycarbonate esters
CA921046A (en)	1973-02-13	Process for the production of acetone-dicarboxylic acid esters
CA875580A (en)	1971-07-13	Process for preparing esters of p-biphenylylacetic acid
CA867718A (en)	1971-04-06	Esters of benzimidazolecarbamic acid as mite ovicides
CA952904A (en)	1974-08-13	Phenoxyacetic acid esters and process for their preparation
CA977745A (en)	1975-11-11	Process for producing pregnane acid derivatives
AU4231672A (en)	1973-11-22	Imidazolinyl-ethyl-dithiocarbamic acid esters and process for their manufacture
CA879135A (en)	1971-08-24	Process for the production of acrylic acid esters
CA834230A (en)	1970-02-10	Process for the production of cyclohexenepolycarboxylic acid esters
CH608502A5 (en)	1979-01-15	Process for the preparation of cyclic phosphinic acid esters