CA931561A - Nucleoside phosphonates, phosphonic acids, phosphonic acid salts, and process for producing same - Google Patents

Nucleoside phosphonates, phosphonic acids, phosphonic acid salts, and process for producing same

Info

Publication number
CA931561A
CA931561A CA075526A CA75526A CA931561A CA 931561 A CA931561 A CA 931561A CA 075526 A CA075526 A CA 075526A CA 75526 A CA75526 A CA 75526A CA 931561 A CA931561 A CA 931561A
Authority
CA
Canada
Prior art keywords
acid salts
phosphonic
producing same
nucleoside phosphonates
phosphonic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA075526A
Inventor
H. Jones Gordon
G. Moffatt John
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Palo Alto LLC
Original Assignee
Roche Palo Alto LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Palo Alto LLC filed Critical Roche Palo Alto LLC
Priority to CA142696A priority Critical patent/CA931562A/en
Application granted granted Critical
Publication of CA931561A publication Critical patent/CA931561A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA075526A 1969-03-10 1970-02-23 Nucleoside phosphonates, phosphonic acids, phosphonic acid salts, and process for producing same Expired CA931561A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA142696A CA931562A (en) 1969-03-10 1972-05-23 Unsaturated nucleoside phosphonates, phosphonic acids, phosphonic acid salts, and process for producing same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80579269A 1969-03-10 1969-03-10

Publications (1)

Publication Number Publication Date
CA931561A true CA931561A (en) 1973-08-07

Family

ID=25192524

Family Applications (1)

Application Number Title Priority Date Filing Date
CA075526A Expired CA931561A (en) 1969-03-10 1970-02-23 Nucleoside phosphonates, phosphonic acids, phosphonic acid salts, and process for producing same

Country Status (4)

Country Link
CA (1) CA931561A (en)
DE (1) DE2009834A1 (en)
FR (1) FR2034785A1 (en)
GB (1) GB1301182A (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3490262T1 (en) * 1983-05-24 1985-11-28 Sri International, Menlo Park, Calif. Antivirus agents
US5047533A (en) * 1983-05-24 1991-09-10 Sri International Acyclic purine phosphonate nucleotide analogs
NZ233197A (en) * 1989-04-13 1991-11-26 Richard Thomas Walker Aromatically substituted nucleotide derivatives, intermediates therefor and pharmaceutical compositions
US5585364A (en) * 1989-04-13 1996-12-17 British Technology Group Limited Antiviral compounds
EP0477454A1 (en) * 1990-09-28 1992-04-01 Merrell Dow Pharmaceuticals Inc. Novel phosphonate derivatives of certain nucleosides
US5672697A (en) * 1991-02-08 1997-09-30 Gilead Sciences, Inc. Nucleoside 5'-methylene phosphonates
US5798340A (en) 1993-09-17 1998-08-25 Gilead Sciences, Inc. Nucleotide analogs
JPH09506333A (en) * 1993-09-17 1997-06-24 ギリアード サイエンシーズ，インコーポレイテッド Method of administering therapeutic compound
EP0719273B1 (en) * 1993-09-17 2010-11-03 Gilead Sciences, Inc. Nucleotide analogs
US5852198A (en) * 1996-04-03 1998-12-22 Medichem Research, Inc. Wittig reagents and method for preparing α,β-unsaturated phosphonates
US5877166A (en) * 1996-04-29 1999-03-02 Sri International Enantiomerically pure 2-aminopurine phosphonate nucleotide analogs as antiviral agents
CN104926905B (en) * 2014-03-20 2018-04-03 北京大学 Trityl class compound and its preparation method and application
CN113880883A (en) * 2021-11-11 2022-01-04 奥锐特药业股份有限公司 Nucleoside phosphate prodrug preparation method

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3238191A (en) * 1962-09-13 1966-03-01 Terrell C Myers Phosphonic acid analogs of nucleoside phosphates and method

Also Published As

Publication number Publication date
FR2034785A1 (en) 1970-12-18
DE2009834A1 (en) 1970-09-17
GB1301182A (en) 1972-12-29

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