CA913077A - Process of preparing n-substituted 14-hydroxydihydronormorphines - Google Patents

Process of preparing n-substituted 14-hydroxydihydronormorphines

Info

Publication number
CA913077A
CA913077A CA913077A CA913077DA CA913077A CA 913077 A CA913077 A CA 913077A CA 913077 A CA913077 A CA 913077A CA 913077D A CA913077D A CA 913077DA CA 913077 A CA913077 A CA 913077A
Authority
CA
Canada
Prior art keywords
hydroxydihydronormorphines
substituted
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA913077A
Inventor
J. Pachter Irwin
Soloway Harold
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ENDO LABORATORIES
Original Assignee
ENDO LABORATORIES
Publication date
Application granted granted Critical
Publication of CA913077A publication Critical patent/CA913077A/en
Expired legal-status Critical Current

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CA913077A Process of preparing n-substituted 14-hydroxydihydronormorphines Expired CA913077A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA913077T

Publications (1)

Publication Number Publication Date
CA913077A true CA913077A (en) 1972-10-24

Family

ID=36420635

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CA913077A Expired CA913077A (en) Process of preparing n-substituted 14-hydroxydihydronormorphines

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Country Link
CA (1) CA913077A (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4161597A (en) * 1976-12-20 1979-07-17 Research Corporation N-alkyl-14-hydroxymorphinans and derivatives
US4232028A (en) * 1979-06-18 1980-11-04 Sisa, Incorporated 17-Cyclobutylmethyl-4,5α-epoxy-3-hydroxy-14-methoxy-8α-methylmorphinan-6-one, and method of treating pain with it
WO1981000409A1 (en) * 1979-08-09 1981-02-19 Mallinckrodt Inc Intermediate compounds for preparation of morphine derivatives
US4322426A (en) * 1980-04-28 1982-03-30 E. I. Du Pont De Nemours And Company 17-Substituted-6-desoxy-7,8-dihydro-6α-methylnoroxymorphone narcotic antagonists
US4451470A (en) * 1982-07-06 1984-05-29 E. I. Du Pont De Nemours And Company Analgesic, antagonist, and/or anorectic 14-fluoromorphinans
US4667037A (en) * 1985-06-06 1987-05-19 E. I. Du Pont De Nemours And Company Dealkylation of opioid ethers
US4795813A (en) * 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
WO1991005768A1 (en) * 1989-10-16 1991-05-02 The United States Of America, Represented By The Secretary, United States Department Of Commerce Total synthesis of northebaine, normorphine, noroxymorphone enantiomers and derivatives via n-nor intermediates
US5668285A (en) * 1986-10-31 1997-09-16 The United States Of America As Represented By The Department Of Health And Human Services Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates
WO2012151669A1 (en) * 2011-05-06 2012-11-15 Brock University Process for the preparation of morphine analogs via metal catalyzed n-demethylation/functionalization and intramolecular group transfer

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4161597A (en) * 1976-12-20 1979-07-17 Research Corporation N-alkyl-14-hydroxymorphinans and derivatives
US4232028A (en) * 1979-06-18 1980-11-04 Sisa, Incorporated 17-Cyclobutylmethyl-4,5α-epoxy-3-hydroxy-14-methoxy-8α-methylmorphinan-6-one, and method of treating pain with it
WO1981000409A1 (en) * 1979-08-09 1981-02-19 Mallinckrodt Inc Intermediate compounds for preparation of morphine derivatives
US4322426A (en) * 1980-04-28 1982-03-30 E. I. Du Pont De Nemours And Company 17-Substituted-6-desoxy-7,8-dihydro-6α-methylnoroxymorphone narcotic antagonists
US4795813A (en) * 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US4451470A (en) * 1982-07-06 1984-05-29 E. I. Du Pont De Nemours And Company Analgesic, antagonist, and/or anorectic 14-fluoromorphinans
US4667037A (en) * 1985-06-06 1987-05-19 E. I. Du Pont De Nemours And Company Dealkylation of opioid ethers
US5668285A (en) * 1986-10-31 1997-09-16 The United States Of America As Represented By The Department Of Health And Human Services Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates
WO1991005768A1 (en) * 1989-10-16 1991-05-02 The United States Of America, Represented By The Secretary, United States Department Of Commerce Total synthesis of northebaine, normorphine, noroxymorphone enantiomers and derivatives via n-nor intermediates
WO2012151669A1 (en) * 2011-05-06 2012-11-15 Brock University Process for the preparation of morphine analogs via metal catalyzed n-demethylation/functionalization and intramolecular group transfer
CN103619847A (en) * 2011-05-06 2014-03-05 布鲁克大学 Process for the preparation of morphine analogs via metal catalyzed N-demethylation/functionalization and intramolecular group transfer
JP2014514339A (en) * 2011-05-06 2014-06-19 ブロック ユニバーシティ Process for the preparation of morphine analogues by metal-catalyzed N-demethylation / functionalization and intramolecular group transfer
US8946214B2 (en) 2011-05-06 2015-02-03 Brock University Process for the preparation of morphine analogs via metal catalyzed N-demethylation/functionalization and intramolecular group transfer
US9108967B2 (en) 2011-05-06 2015-08-18 Brock University Process for the preparation of morphine analogs via metal catalyzed N-demethylation/functionalization and intramolecular group transfer
US9533993B2 (en) 2011-05-06 2017-01-03 Brock University Process for the preparation of morphine analogs via metal catalyzed N-demethylation/functionalization and intramolecular group transfer

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