CA3234821A1 - Methodes de culture de cellules immunitaires - Google Patents
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- CA3234821A1 CA3234821A1 CA3234821A CA3234821A CA3234821A1 CA 3234821 A1 CA3234821 A1 CA 3234821A1 CA 3234821 A CA3234821 A CA 3234821A CA 3234821 A CA3234821 A CA 3234821A CA 3234821 A1 CA3234821 A1 CA 3234821A1
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- C12N2500/14—Calcium; Ca chelators; Calcitonin
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- C12N2527/00—Culture process characterised by the use of mechanical forces, e.g. strain, vibration
Abstract
La présente divulgation concerne des méthodes de culture de TIL dans un milieu comprenant des ions potassium à une concentration d'au moins environ 30 mM à au moins environ 100 mM. Selon certains aspects, les méthodes divulguées ici améliorent l'expansion des TIL CD8+, par rapport aux TIL CD4+. Selon certains aspects, les méthodes divulguées ici augmentent le nombre de cellules moins différenciées, par exemple de TIL moins différenciés, dans la population de cellules. Selon certains aspects, les méthodes divulguées ici assurent un enrichissement en TIL réagissant aux tumeurs, par exemple spécifiques à une tumeur, de façon à préserver la diversité clonale. Selon certains aspects, les cellules, par exemple les TIL, sont administrées à un sujet en ayant besoin.
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JP2021512962A (ja) | 2018-02-13 | 2021-05-20 | アイオバンス バイオセラピューティクス,インコーポレイテッド | アデノシンa2a受容体アンタゴニストによる腫瘍浸潤性リンパ球(til)の拡大培養並びにtil及びアデノシンa2a受容体アンタゴニストの治療的組み合わせ |
WO2019217753A1 (fr) | 2018-05-10 | 2019-11-14 | Iovance Biotherapeutics, Inc. | Procédés de production de lymphocytes infiltrant les tumeurs et leurs utilisations en immunothérapie |
EP3870600A1 (fr) | 2018-10-24 | 2021-09-01 | Obsidian Therapeutics, Inc. | Régulation de protéine accordable par er |
MX2021004775A (es) | 2018-11-05 | 2021-06-08 | Iovance Biotherapeutics Inc | Expansion de linfocitos infiltrantes de tumores (tils) usando inhibidores de la via de proteina cinasa b (akt). |
AU2020408017A1 (en) | 2019-12-20 | 2022-07-14 | Instil Bio (Uk) Limited | Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof |
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2022
- 2022-10-27 AU AU2022377637A patent/AU2022377637A1/en active Pending
- 2022-10-27 CA CA3234821A patent/CA3234821A1/fr active Pending
- 2022-10-27 WO PCT/US2022/078827 patent/WO2023077034A1/fr active Application Filing
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AU2022377637A1 (en) | 2024-05-02 |
WO2023077034A1 (fr) | 2023-05-04 |
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