CA3173628A1 - Leurres proteiques de novo de l'enzyme 2 de conversion de l'angiotensine (ace2) - Google Patents

Leurres proteiques de novo de l'enzyme 2 de conversion de l'angiotensine (ace2) Download PDF

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Publication number
CA3173628A1
CA3173628A1 CA3173628A CA3173628A CA3173628A1 CA 3173628 A1 CA3173628 A1 CA 3173628A1 CA 3173628 A CA3173628 A CA 3173628A CA 3173628 A CA3173628 A CA 3173628A CA 3173628 A1 CA3173628 A1 CA 3173628A1
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CA
Canada
Prior art keywords
amino acid
seq
substituted
decoy
ace2 protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3173628A
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English (en)
Inventor
Thomas Linsky
Daniel Adriano SILVA MANZANO
Nuria CODINA CASTILLO
Jorgen NELSON
Matthew James Walker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neoleukin Therapeutics Inc
Original Assignee
Neoleukin Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neoleukin Therapeutics Inc filed Critical Neoleukin Therapeutics Inc
Publication of CA3173628A1 publication Critical patent/CA3173628A1/fr
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596Molecules with a "CD"-designation not provided for elsewhere
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4813Exopeptidases (3.4.11. to 3.4.19)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/485Exopeptidases (3.4.11-3.4.19)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/17Metallocarboxypeptidases (3.4.17)
    • C12Y304/17023Angiotensin-converting enzyme 2 (3.4.17.23)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Vascular Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne des leurres protéiques de novo de ACE2 et leurs utilisations. Selon certains modes de réalisation, l'invention concerne des procédés de traitement d'une infection à coronavirus à l'aide des leurres protéiques de ACE2.
CA3173628A 2020-04-07 2021-04-06 Leurres proteiques de novo de l'enzyme 2 de conversion de l'angiotensine (ace2) Pending CA3173628A1 (fr)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US202063006463P 2020-04-07 2020-04-07
US63/006,463 2020-04-07
US202063028401P 2020-05-21 2020-05-21
US63/028,401 2020-05-21
US202062705150P 2020-06-13 2020-06-13
US62/705,150 2020-06-13
US202063055051P 2020-07-22 2020-07-22
US63/055,051 2020-07-22
US202063060489P 2020-08-03 2020-08-03
US63/060,489 2020-08-03
US202063094179P 2020-10-20 2020-10-20
US63/094,179 2020-10-20
US202163145352P 2021-02-03 2021-02-03
US63/145,352 2021-02-03
PCT/US2021/025974 WO2021207207A2 (fr) 2020-04-07 2021-04-06 Leurres protéiques de novo de l'enzyme 2 de conversion de l'angiotensine (ace2)

Publications (1)

Publication Number Publication Date
CA3173628A1 true CA3173628A1 (fr) 2021-10-14

Family

ID=75675016

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3173628A Pending CA3173628A1 (fr) 2020-04-07 2021-04-06 Leurres proteiques de novo de l'enzyme 2 de conversion de l'angiotensine (ace2)

Country Status (7)

Country Link
EP (1) EP4132964A2 (fr)
JP (1) JP2023521706A (fr)
KR (1) KR20220164736A (fr)
CN (1) CN115515972A (fr)
AU (1) AU2021251760A1 (fr)
CA (1) CA3173628A1 (fr)
WO (1) WO2021207207A2 (fr)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005032487A2 (fr) * 2003-10-06 2005-04-14 The Brigham And Women's Hospital, Inc. Enzyme de conversion de l'angiotensine 2 comme recepteur du coronavirus sras
AR105616A1 (es) 2015-05-07 2017-10-25 Lilly Co Eli Proteínas de fusión
EP3585806A1 (fr) 2017-02-24 2020-01-01 Philogen S.p.A. Immunoconjugués présentant des agents de liaison et une orientation optimisés
ES2894731T3 (es) 2017-03-15 2022-02-15 Silverback Therapeutics Inc Compuestos de benzazepina, conjugados y usos de los mismos
CN112512544A (zh) * 2018-07-19 2021-03-16 华盛顿大学 蛋白质开关的全新设计

Also Published As

Publication number Publication date
WO2021207207A3 (fr) 2021-11-25
AU2021251760A1 (en) 2022-10-06
WO2021207207A2 (fr) 2021-10-14
EP4132964A2 (fr) 2023-02-15
CN115515972A (zh) 2022-12-23
JP2023521706A (ja) 2023-05-25
KR20220164736A (ko) 2022-12-13

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EEER Examination request

Effective date: 20220927

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EEER Examination request

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EEER Examination request

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