CA3149152A1 - Compositions et procedes pour ameliorer la mobilisation de recepteur opioide par des hexadienoates d'opioides et des hexadienoates eventuellement substitues - Google Patents
Compositions et procedes pour ameliorer la mobilisation de recepteur opioide par des hexadienoates d'opioides et des hexadienoates eventuellement substitues Download PDFInfo
- Publication number
- CA3149152A1 CA3149152A1 CA3149152A CA3149152A CA3149152A1 CA 3149152 A1 CA3149152 A1 CA 3149152A1 CA 3149152 A CA3149152 A CA 3149152A CA 3149152 A CA3149152 A CA 3149152A CA 3149152 A1 CA3149152 A1 CA 3149152A1
- Authority
- CA
- Canada
- Prior art keywords
- hexadienoate
- compound
- opioid
- naloxone
- methylhexadienoate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/20—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C219/22—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/26—Benzomorphans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Addiction (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La présente invention concerne des compositions dérivées d'opiacés et leurs antagonistes utiles dans des domaines thérapeutiques associées à la modulation des récepteurs opioïdes. Une modification de 3-hexanediénoate des opioïdes est formulée pour améliorer la mobilisation d'opiacés des récepteurs opioïdes lorsqu'ils sont administrés par voie orale. L'invention concerne une modification de 3-hexanediénoate de Nalbuphine ou d'un sel pharmaceutiquement acceptable de celle-ci pour améliorer la qualité de la gestion de la douleur lorsqu'elle est administrée par voie intraveineuse, intranasale, transdermique, sublinguale, rectale, topique, intramusculaire, sous-cutanée ou par inhalation. Une modification de 3-hexanediénoate des antagonistes d'opioïdes est formulée pour améliorer l'inhibition des récepteurs opioïdes lorsqu'ils sont administrés par voie orale. L'invention concerne une modification de 3-hexanediénoate de Naloxone ou d'un sel pharmaceutiquement acceptable de celle-ci pour améliorer la qualité du sevrage lorsqu'elle est administrée par voie intraveineuse, intranasale, transdermique, sublinguale, rectale, topique, intramusculaire, sous-cutanée ou par inhalation.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962885311P | 2019-08-11 | 2019-08-11 | |
| US62/885,311 | 2019-08-11 | ||
| US16/540,058 | 2019-08-14 | ||
| US16/540,058 US11186585B2 (en) | 2018-08-17 | 2019-08-14 | Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates |
| PCT/US2020/021599 WO2021029914A1 (fr) | 2019-08-11 | 2020-03-07 | Compositions et procédés pour améliorer la mobilisation de récepteur opioïde par des héxadiénoates d'opioïdes et des héxadiénoates éventuellement substitués |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3149152A1 true CA3149152A1 (fr) | 2021-02-18 |
Family
ID=74571142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3149152A Pending CA3149152A1 (fr) | 2019-08-11 | 2020-03-07 | Compositions et procedes pour ameliorer la mobilisation de recepteur opioide par des hexadienoates d'opioides et des hexadienoates eventuellement substitues |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP4010078A4 (fr) |
| JP (1) | JP2022544564A (fr) |
| CN (1) | CN114828961B (fr) |
| CA (1) | CA3149152A1 (fr) |
| MX (1) | MX2022001520A (fr) |
| WO (1) | WO2021029914A1 (fr) |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4668685A (en) | 1984-07-05 | 1987-05-26 | E.I. Du Pont De Nemours And Company | Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists |
| EP0615756B1 (fr) * | 1993-03-15 | 2001-06-27 | National Science Council | Esters de nalbuphine, et compositions pharmaceutiques à action prolongée les contenant |
| CN1050130C (zh) | 1997-07-04 | 2000-03-08 | 卢正堂 | 纳洛酮酸脂和纳屈酮酸脂及系列物和制备方法 |
| DE60001487T2 (de) | 2000-04-27 | 2003-12-24 | Oliver Yoa-Pu Hu | Polynalbuphinderivat |
| TWI226239B (en) | 2000-05-15 | 2005-01-11 | You-Pu Hu | Novel oral pharmaceutical composition containing nalbuphine ester prodrug |
| CA2417389C (fr) | 2000-07-27 | 2012-05-29 | Rutgers, The State University | Polyesters et polyamides therapeutiques |
| US20040033253A1 (en) | 2002-02-19 | 2004-02-19 | Ihor Shevchuk | Acyl opioid antagonists |
| US7759358B2 (en) | 2003-07-23 | 2010-07-20 | Crooks Peter A | Oral bioavailable prodrugs |
| US20050137141A1 (en) | 2003-10-24 | 2005-06-23 | John Hilfinger | Prodrug composition |
| WO2007022535A2 (fr) | 2005-08-19 | 2007-02-22 | Pharmacofore, Inc. | Promedicaments d'agents actifs |
| WO2009092073A2 (fr) | 2008-01-18 | 2009-07-23 | Shire Llc | Promédicaments à base d'acides aminés et de peptides d'analgésiques opioïdes avec effets secondaires gi réduits |
| JP2013523599A (ja) | 2009-04-02 | 2013-06-17 | シャイア エルエルシー | 新規なオピオイドのジカルボン酸結合アミノ酸及びペプチドプロドラッグ並びにその用途 |
| WO2011007247A1 (fr) | 2009-07-17 | 2011-01-20 | Llc Shire | Nouvel acide amine de carbamate et promedicaments peptidiques d'opioïdes, et utilisations associees |
| WO2011083304A1 (fr) | 2010-01-05 | 2011-07-14 | Shire Llc | Promédicaments d'opioïdes et leurs utilisations |
| JP5941038B2 (ja) * | 2010-04-02 | 2016-06-29 | ジネルバ ファーマシューティカルズ， インコーポレイティド | 経皮送達可能なオピオイドプロドラッグ、乱用抵抗性組成物及びオピオイドプロドラッグを使用する方法 |
| US10449190B2 (en) * | 2015-04-27 | 2019-10-22 | John K. Thottathil | Alpha-hydroxy carboxylic acid and derivatives and other GRAS-based prodrugs of opioids and uses thereof |
| US10017519B2 (en) * | 2015-04-27 | 2018-07-10 | 3St Research Llc | Alpha-hydroxy carboxylic acid and derivatives and other GRAS based prodrugs of oxycodone and uses thereof |
| US9974858B2 (en) * | 2015-08-29 | 2018-05-22 | Medrx Co., Ltd | Percutaneous absorption composition |
| US11186585B2 (en) * | 2018-08-17 | 2021-11-30 | Kappa-Pharma LLC | Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates |
-
2020
- 2020-03-07 CN CN202080071185.9A patent/CN114828961B/zh active Active
- 2020-03-07 WO PCT/US2020/021599 patent/WO2021029914A1/fr active Application Filing
- 2020-03-07 EP EP20852037.9A patent/EP4010078A4/fr active Pending
- 2020-03-07 JP JP2022509137A patent/JP2022544564A/ja active Pending
- 2020-03-07 CA CA3149152A patent/CA3149152A1/fr active Pending
- 2020-03-07 MX MX2022001520A patent/MX2022001520A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021029914A1 (fr) | 2021-02-18 |
| CN114828961B (zh) | 2024-03-29 |
| JP2022544564A (ja) | 2022-10-19 |
| EP4010078A1 (fr) | 2022-06-15 |
| EP4010078A4 (fr) | 2023-08-09 |
| MX2022001520A (es) | 2022-07-21 |
| CN114828961A (zh) | 2022-07-29 |
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