CA3144650A1 - Inhibiteurs de cxcr4 et leurs utilisations - Google Patents

Inhibiteurs de cxcr4 et leurs utilisations Download PDF

Info

Publication number
CA3144650A1
CA3144650A1 CA3144650A CA3144650A CA3144650A1 CA 3144650 A1 CA3144650 A1 CA 3144650A1 CA 3144650 A CA3144650 A CA 3144650A CA 3144650 A CA3144650 A CA 3144650A CA 3144650 A1 CA3144650 A1 CA 3144650A1
Authority
CA
Canada
Prior art keywords
compound
cancer
carcinoma
optionally substituted
nitrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3144650A
Other languages
English (en)
Inventor
Renato Skerlj
Elyse Marie Josee Bourque
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
X4 Pharmaceuticals Inc
Original Assignee
X4 Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by X4 Pharmaceuticals Inc filed Critical X4 Pharmaceuticals Inc
Publication of CA3144650A1 publication Critical patent/CA3144650A1/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Abstract

La présente invention concerne des composés et des procédés d'inhibition du récepteur C-X-C de type 4 (CXCR4). L'invention concerne également des compositions pharmaceutiquement acceptables comprenant des composés de la présente invention et des procédés d'utilisation desdites compositions dans le traitement de diverses maladies.
CA3144650A 2019-06-26 2020-06-26 Inhibiteurs de cxcr4 et leurs utilisations Pending CA3144650A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962867003P 2019-06-26 2019-06-26
US62/867,003 2019-06-26
PCT/US2020/039816 WO2020264292A1 (fr) 2019-06-26 2020-06-26 Inhibiteurs de cxcr4 et leurs utilisations

Publications (1)

Publication Number Publication Date
CA3144650A1 true CA3144650A1 (fr) 2020-12-30

Family

ID=74059964

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3144650A Pending CA3144650A1 (fr) 2019-06-26 2020-06-26 Inhibiteurs de cxcr4 et leurs utilisations

Country Status (5)

Country Link
EP (1) EP3990456A1 (fr)
JP (1) JP2022538138A (fr)
CN (1) CN114206869A (fr)
CA (1) CA3144650A1 (fr)
WO (1) WO2020264292A1 (fr)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2374804A1 (fr) * 2003-04-22 2011-10-12 Genzyme Corporation Composés hétérocycliques de liaison de récepteur de chemokine avec une efficacité améliorée
US7501518B2 (en) * 2003-04-22 2009-03-10 Genzyme Corporation Methods of making 2,6-diaryl piperidine derivatives
CN109640988A (zh) * 2016-06-21 2019-04-16 X4 制药有限公司 Cxcr4抑制剂及其用途
CN116554168A (zh) * 2016-06-21 2023-08-08 X4 制药有限公司 Cxcr4抑制剂及其用途

Also Published As

Publication number Publication date
JP2022538138A (ja) 2022-08-31
CN114206869A (zh) 2022-03-18
WO2020264292A1 (fr) 2020-12-30
EP3990456A1 (fr) 2022-05-04

Similar Documents

Publication Publication Date Title
JP7402549B2 (ja) Ｃｘｃｒ４阻害剤およびその使用
JP6994767B2 (ja) Ｃｘｃｒ４阻害剤およびその使用
JP7084624B2 (ja) Ｃｘｃｒ４阻害剤およびその使用
US20210009557A1 (en) Acyclic cxcr4 inhibitors and uses thereof
WO2022051567A1 (fr) Pyrido[2,3-b]pyrazinones substituées et composés apparentés et leur utilisation dans le traitement d'états médicaux
EP3846793B1 (fr) Inhibiteurs d'eif4e et leurs utilisations
WO2021263203A1 (fr) Inhibiteurs de cxcr4 et leurs utilisations
CA3215081A1 (fr) Inhibiteurs de mek et leurs utilisations
CA3144650A1 (fr) Inhibiteurs de cxcr4 et leurs utilisations
CA3212520A1 (fr) Derives de la salinomycine et leurs utilisations
WO2023173057A1 (fr) Inhibiteurs de mek et leurs utilisations
WO2024081311A1 (fr) Modulateurs de cbl-b et leurs utilisations
US20220017487A1 (en) Deuterated compounds and uses thereof