CA3125646A1 - Expansion de cellules modifiees et ses utilisations - Google Patents
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- CA3125646A1 CA3125646A1 CA3125646A CA3125646A CA3125646A1 CA 3125646 A1 CA3125646 A1 CA 3125646A1 CA 3125646 A CA3125646 A CA 3125646A CA 3125646 A CA3125646 A CA 3125646A CA 3125646 A1 CA3125646 A1 CA 3125646A1
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Abstract
La présente invention concerne des compositions et des méthodes permettant d'améliorer une réponse de lymphocytes T et/ou une expansion des cellules CAR et/ou un maintien in vivo et/ou in vitro. Par exemple, une méthode d'amélioration d'une thérapie à base de lymphocytes T consiste à administrer une population mixte de lymphocytes T comprenant des lymphocytes T modifiés comprenant un premier récepteur d'antigène chimère (CAR) et des lymphocytes T modifiés comprenant un second CAR, un domaine de liaison du premier CAR se liant à un premier antigène, et un domaine de liaison du second CAR se liant à un second antigène. Le premier antigène est différent du second antigène. Selon certains modes de réalisation, le premier CAR se lie à une molécule de surface ou à un antigène d'un leucocyte.
Applications Claiming Priority (19)
| Application Number | Priority Date | Filing Date | Title |
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| US201962790783P | 2019-01-10 | 2019-01-10 | |
| US62/790,783 | 2019-01-10 | ||
| US201962799462P | 2019-01-31 | 2019-01-31 | |
| US62/799,462 | 2019-01-31 | ||
| US201962816497P | 2019-03-11 | 2019-03-11 | |
| US62/816,497 | 2019-03-11 | ||
| US201962817322P | 2019-03-12 | 2019-03-12 | |
| US62/817,322 | 2019-03-12 | ||
| US16/387,166 US10869888B2 (en) | 2018-04-17 | 2019-04-17 | Modified cell expansion and uses thereof |
| US16/387,166 | 2019-04-17 | ||
| US201962846563P | 2019-05-10 | 2019-05-10 | |
| US62/846,563 | 2019-05-10 | ||
| US62/848,961 | 2019-05-16 | ||
| US16/445,965 | 2019-06-19 | ||
| US62/889,926 | 2019-08-21 | ||
| US62/891,131 | 2019-08-23 | ||
| US62/902,766 | 2019-09-19 | ||
| US62/932,587 | 2019-11-08 | ||
| PCT/US2020/013099 WO2020146743A1 (fr) | 2019-01-10 | 2020-01-10 | Expansion de cellules modifiées et ses utilisations |
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| Publication Number | Publication Date |
|---|---|
| CA3125646A1 true CA3125646A1 (fr) | 2020-07-16 |
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| CA3125646A Pending CA3125646A1 (fr) | 2019-01-10 | 2020-01-10 | Expansion de cellules modifiees et ses utilisations |
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| CA (1) | CA3125646A1 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113563482A (zh) * | 2021-08-03 | 2021-10-29 | 北京安北生物医药科技有限公司 | Cd19靶向性的嵌合抗原受体及其应用 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113563482A (zh) * | 2021-08-03 | 2021-10-29 | 北京安北生物医药科技有限公司 | Cd19靶向性的嵌合抗原受体及其应用 |
| CN113563482B (zh) * | 2021-08-03 | 2023-02-28 | 安北生物医药(宜兴)有限公司 | Cd19靶向性的嵌合抗原受体及其应用 |
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