CA3090505A1 - Antifolates gamma-polyglutamates et utilisations associees - Google Patents
Antifolates gamma-polyglutamates et utilisations associees Download PDFInfo
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- CA3090505A1 CA3090505A1 CA3090505A CA3090505A CA3090505A1 CA 3090505 A1 CA3090505 A1 CA 3090505A1 CA 3090505 A CA3090505 A CA 3090505A CA 3090505 A CA3090505 A CA 3090505A CA 3090505 A1 CA3090505 A1 CA 3090505A1
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- antifolate
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- C—CHEMISTRY; METALLURGY
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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Landscapes
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Abstract
L'invention concerne d'une manière générale des antifolates gamma-polyglutamatés, des formulations contenant des liposomes remplis d'antifolates gamma-polyglutamatés, des procédés de préparation d'antifolates gamma-polyglutamatés et des formulations contenant des liposomes, et des méthodes d'utilisation d'antifolates gamma-polyglutamatés et des formulations contenant des liposomes pour le traitement de troubles hyperprolifératifs (par exemple, du cancer) et de troubles du système immunitaire (par exemple, d'une inflammation et d'une maladie auto-immune telle que la polyarthrite rhumatoïde).<i /> <i />
Applications Claiming Priority (29)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862627733P | 2018-02-07 | 2018-02-07 | |
US201862627732P | 2018-02-07 | 2018-02-07 | |
US62/627,733 | 2018-02-07 | ||
US62/627,732 | 2018-02-07 | ||
US201862630625P | 2018-02-14 | 2018-02-14 | |
US201862630751P | 2018-02-14 | 2018-02-14 | |
US201862630652P | 2018-02-14 | 2018-02-14 | |
US201862630824P | 2018-02-14 | 2018-02-14 | |
US201862630613P | 2018-02-14 | 2018-02-14 | |
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CA3033077C (fr) | 2016-08-12 | 2024-06-18 | L.E.A.F. Holdings Group Llc | Antifolates alpha et gamma-d de polyglutamates et leurs utilisations |
WO2019157138A1 (fr) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Pémétrexed alpha-polyglutamaté et utilisations associées |
EP3749316A4 (fr) | 2018-02-07 | 2021-10-27 | L.E.A.F Holdings Group LLC | Pralatrexate alpha-polyglutamaté et utilisations associées |
WO2019160732A1 (fr) * | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Aminoptérine gamma polyglutamique et ses utilisations |
CA3090989A1 (fr) * | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Methotrexate gamma polyglutamique et ses utilisations |
CA3090992A1 (fr) | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Tetrahydrofolates gamma polyglutamiques et leurs utilisations |
US12048767B2 (en) | 2018-02-14 | 2024-07-30 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated pralatrexate and uses thereof |
CA3090875A1 (fr) | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Lometrexol gamma polyglutamique et ses utilisations |
US20230000997A1 (en) * | 2019-08-06 | 2023-01-05 | L.E.A.F. Holdings Group Llc | Processes of preparing polyglutamated antifolates and uses of their compositions |
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US7612071B2 (en) * | 2004-03-12 | 2009-11-03 | Syntrix Biosystems, Inc. | Compositions and methods employing aminopterin |
CA2579096C (fr) * | 2004-09-08 | 2012-11-13 | Chelsea Therapeutics, Inc. | Antifoliques metaboliquement inertes utiles dans le traitement des maladies liees a la proliferation cellulaire anormale et a une inflammation |
US7687473B2 (en) * | 2005-01-07 | 2010-03-30 | Health Research, Inc. | 5-amino-4-imidazolecarboxamide riboside and its nucleobase as potentiators of antifolate transport and metabolism |
US8073630B2 (en) * | 2006-08-30 | 2011-12-06 | Exagen Diagnostics, Inc. | Pharacogenetic method for prediction of the efficacy of methotrexate monotherapy in recent-onset arthritis |
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CA2674698A1 (fr) * | 2007-01-19 | 2008-07-24 | Chelsea Therapeutics, Inc. | Nouveaux antifolates classiques |
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US9770414B2 (en) * | 2010-05-13 | 2017-09-26 | Pacira Pharmaceuticals, Inc. | Sustained release formulation of methotrexate as a disease-modifying antirheumatic drug (DMARD) and an anti-cancer agent |
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CA3090381A1 (fr) * | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Lometrexol alpha-polyglutamate et utilisations associees |
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EP3749316A4 (fr) * | 2018-02-07 | 2021-10-27 | L.E.A.F Holdings Group LLC | Pralatrexate alpha-polyglutamaté et utilisations associées |
WO2019157145A1 (fr) * | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Compositions de pémétrexed polyglutamaté gamma et leurs utilisations |
CN111936146A (zh) * | 2018-02-07 | 2020-11-13 | L.E.A.F.控股集团公司 | α聚谷氨酸化四氢叶酸及其用途 |
CA3090989A1 (fr) * | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Methotrexate gamma polyglutamique et ses utilisations |
CA3090992A1 (fr) * | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Tetrahydrofolates gamma polyglutamiques et leurs utilisations |
US12048767B2 (en) * | 2018-02-14 | 2024-07-30 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated pralatrexate and uses thereof |
CA3090875A1 (fr) * | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Lometrexol gamma polyglutamique et ses utilisations |
WO2019160732A1 (fr) * | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Aminoptérine gamma polyglutamique et ses utilisations |
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EP3749321A1 (fr) | 2020-12-16 |
CN111936147A (zh) | 2020-11-13 |
WO2019157148A1 (fr) | 2019-08-15 |
EP3749321A4 (fr) | 2022-03-09 |
JP2021513533A (ja) | 2021-05-27 |
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