CA3045243A1 - Polytherapie - Google Patents

Polytherapie Download PDF

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Publication number
CA3045243A1
CA3045243A1 CA3045243A CA3045243A CA3045243A1 CA 3045243 A1 CA3045243 A1 CA 3045243A1 CA 3045243 A CA3045243 A CA 3045243A CA 3045243 A CA3045243 A CA 3045243A CA 3045243 A1 CA3045243 A1 CA 3045243A1
Authority
CA
Canada
Prior art keywords
seq
antibody
optionally substituted
set forth
immuno
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA3045243A
Other languages
English (en)
Inventor
Olena Barbash
Susan KORENCHUK
Christian SHERK
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline Intellectual Property Development Ltd
Original Assignee
GlaxoSmithKline Intellectual Property Development Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GlaxoSmithKline Intellectual Property Development Ltd filed Critical GlaxoSmithKline Intellectual Property Development Ltd
Publication of CA3045243A1 publication Critical patent/CA3045243A1/fr
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne l'association d'un inhibiteur de la protéine arginine N-méthyltransférase de type II (PRMT de type II) et d'un agent immunomodulateur, l'agent immunomodulateur étant un anticorps anti-OX40 ou un fragment de liaison à l'antigène de ce dernier. La présente invention concerne également des méthodes de traitement du cancer chez le patient humain dont l'état nécessite de tels traitements, les méthodes comprenant l'administration au patient d'une association d'un inhibiteur de la PRM de type II et d'un agent immunomodulateur, l'agent immunomodulateur étant un anticorps anti-OX40 ou un fragment de liaison à l'antigène de ce dernier, avec au moins l'un des constituants suivants : un support pharmaceutiquement acceptable et un diluant pharmaceutiquement acceptable, l'invention permettant de cette façon de traiter le cancer chez l'humain. La présente invention concerne en outre une composition pharmaceutique comprenant une quantité thérapeutiquement efficace d'un inhibiteur de de la PRM de type II et une seconde composition pharmaceutique comprenant une quantité thérapeutiquement efficace d'un agent immunomodulateur, l'agent immunomodulateur étant un anticorps anti-OX40 ou un fragment de liaison à l'antigène de ce dernier.
CA3045243A 2016-12-01 2017-11-30 Polytherapie Abandoned CA3045243A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662428764P 2016-12-01 2016-12-01
US62/428,764 2016-12-01
US201662433363P 2016-12-13 2016-12-13
US62/433,363 2016-12-13
PCT/IB2017/057549 WO2018100535A1 (fr) 2016-12-01 2017-11-30 Polythérapie

Publications (1)

Publication Number Publication Date
CA3045243A1 true CA3045243A1 (fr) 2018-06-07

Family

ID=60782286

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3045243A Abandoned CA3045243A1 (fr) 2016-12-01 2017-11-30 Polytherapie

Country Status (8)

Country Link
EP (1) EP3548068A1 (fr)
JP (1) JP2020511407A (fr)
KR (1) KR20190090823A (fr)
CN (1) CN110234342A (fr)
AU (1) AU2017369994A1 (fr)
BR (1) BR112019011350A2 (fr)
CA (1) CA3045243A1 (fr)
WO (1) WO2018100535A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201905780D0 (en) 2019-04-25 2019-06-05 La Thangue Nicholas Cancer therapy
CN110950841A (zh) * 2019-11-22 2020-04-03 济南大学 一类新型***类化合物的合成及应用
US20230301998A1 (en) * 2020-05-04 2023-09-28 Sanford Burnham Prebys Medical Discovery Institute Methods and compositions for induction of antitumor immunity
CN113908283A (zh) * 2021-09-30 2022-01-11 上海交通大学医学院附属新华医院 Prmt5抑制剂及其与pd-l1抗体阻断剂联合在治疗肺癌上的应用

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Also Published As

Publication number Publication date
BR112019011350A2 (pt) 2019-10-22
JP2020511407A (ja) 2020-04-16
KR20190090823A (ko) 2019-08-02
CN110234342A (zh) 2019-09-13
EP3548068A1 (fr) 2019-10-09
AU2017369994A1 (en) 2019-06-13
WO2018100535A1 (fr) 2018-06-07

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20230530