CA3022449A1 - Nicotine inhaler system - Google Patents
Nicotine inhaler system Download PDFInfo
- Publication number
- CA3022449A1 CA3022449A1 CA3022449A CA3022449A CA3022449A1 CA 3022449 A1 CA3022449 A1 CA 3022449A1 CA 3022449 A CA3022449 A CA 3022449A CA 3022449 A CA3022449 A CA 3022449A CA 3022449 A1 CA3022449 A1 CA 3022449A1
- Authority
- CA
- Canada
- Prior art keywords
- receptacle
- capsule
- nicotine
- mouthpiece
- inhaler
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 title claims abstract description 104
- 229960002715 nicotine Drugs 0.000 title claims abstract description 100
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 title claims abstract description 100
- 239000002775 capsule Substances 0.000 claims abstract description 114
- 239000002245 particle Substances 0.000 claims abstract description 109
- 239000012528 membrane Substances 0.000 claims abstract description 77
- 230000013011 mating Effects 0.000 claims description 26
- 239000007787 solid Substances 0.000 claims description 6
- 238000007789 sealing Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims 5
- 230000008878 coupling Effects 0.000 claims 3
- 238000010168 coupling process Methods 0.000 claims 3
- 238000005859 coupling reaction Methods 0.000 claims 3
- 239000012530 fluid Substances 0.000 claims 2
- 239000000796 flavoring agent Substances 0.000 description 76
- 235000019634 flavors Nutrition 0.000 description 56
- 239000000843 powder Substances 0.000 description 39
- 150000001875 compounds Chemical class 0.000 description 11
- 230000000391 smoking effect Effects 0.000 description 11
- 210000004072 lung Anatomy 0.000 description 10
- 239000000203 mixture Substances 0.000 description 10
- 239000000463 material Substances 0.000 description 9
- 238000009472 formulation Methods 0.000 description 6
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 5
- 238000005054 agglomeration Methods 0.000 description 5
- 230000002776 aggregation Effects 0.000 description 5
- 239000011800 void material Substances 0.000 description 5
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 4
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 4
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 4
- 229930195725 Mannitol Natural products 0.000 description 4
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 description 4
- 150000001720 carbohydrates Chemical class 0.000 description 4
- 239000008101 lactose Substances 0.000 description 4
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 239000000594 mannitol Substances 0.000 description 4
- 235000010355 mannitol Nutrition 0.000 description 4
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 4
- 244000299461 Theobroma cacao Species 0.000 description 3
- 229940024606 amino acid Drugs 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 235000021474 generally recognized As safe (food) Nutrition 0.000 description 3
- 235000021473 generally recognized as safe (food ingredients) Nutrition 0.000 description 3
- 229960003136 leucine Drugs 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 2
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 2
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 2
- JZBCTZLGKSYRSF-UHFFFAOYSA-N 2-Ethyl-3,5-dimethylpyrazine Chemical compound CCC1=NC=C(C)N=C1C JZBCTZLGKSYRSF-UHFFFAOYSA-N 0.000 description 2
- MMOPGICOOYBFJU-UHFFFAOYSA-N 3-(1-methylpyrrolidin-2-yl)pyridine;2-oxopropanoic acid Chemical compound CC(=O)C(O)=O.CN1CCCC1C1=CC=CN=C1 MMOPGICOOYBFJU-UHFFFAOYSA-N 0.000 description 2
- FFYVQVZXWDGRAY-UHFFFAOYSA-N 3-(1-methylpyrrolidin-2-yl)pyridine;hydrate Chemical compound O.CN1CCCC1C1=CC=CN=C1 FFYVQVZXWDGRAY-UHFFFAOYSA-N 0.000 description 2
- XPCTZQVDEJYUGT-UHFFFAOYSA-N 3-hydroxy-2-methyl-4-pyrone Chemical compound CC=1OC=CC(=O)C=1O XPCTZQVDEJYUGT-UHFFFAOYSA-N 0.000 description 2
- INAXVXBDKKUCGI-UHFFFAOYSA-N 4-hydroxy-2,5-dimethylfuran-3-one Chemical compound CC1OC(C)=C(O)C1=O INAXVXBDKKUCGI-UHFFFAOYSA-N 0.000 description 2
- 244000223760 Cinnamomum zeylanicum Species 0.000 description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 2
- 235000019454 L-leucine Nutrition 0.000 description 2
- 239000004395 L-leucine Substances 0.000 description 2
- 244000024873 Mentha crispa Species 0.000 description 2
- 235000014749 Mentha crispa Nutrition 0.000 description 2
- 244000246386 Mentha pulegium Species 0.000 description 2
- 235000016257 Mentha pulegium Nutrition 0.000 description 2
- 235000004357 Mentha x piperita Nutrition 0.000 description 2
- HSHXDCVZWHOWCS-UHFFFAOYSA-N N'-hexadecylthiophene-2-carbohydrazide Chemical compound CCCCCCCCCCCCCCCCNNC(=O)c1cccs1 HSHXDCVZWHOWCS-UHFFFAOYSA-N 0.000 description 2
- 244000061176 Nicotiana tabacum Species 0.000 description 2
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 2
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 description 2
- POIARNZEYGURDG-FNORWQNLSA-N beta-damascenone Chemical compound C\C=C\C(=O)C1=C(C)C=CCC1(C)C POIARNZEYGURDG-FNORWQNLSA-N 0.000 description 2
- 235000019219 chocolate Nutrition 0.000 description 2
- 235000019504 cigarettes Nutrition 0.000 description 2
- 235000017803 cinnamon Nutrition 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- CBOQJANXLMLOSS-UHFFFAOYSA-N ethyl vanillin Chemical group CCOC1=CC(C=O)=CC=C1O CBOQJANXLMLOSS-UHFFFAOYSA-N 0.000 description 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
- 239000011888 foil Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000012458 free base Substances 0.000 description 2
- 239000008369 fruit flavor Substances 0.000 description 2
- LHGVFZTZFXWLCP-UHFFFAOYSA-N guaiacol Chemical compound COC1=CC=CC=C1O LHGVFZTZFXWLCP-UHFFFAOYSA-N 0.000 description 2
- CATSNJVOTSVZJV-UHFFFAOYSA-N heptan-2-one Chemical compound CCCCCC(C)=O CATSNJVOTSVZJV-UHFFFAOYSA-N 0.000 description 2
- 235000001050 hortel pimenta Nutrition 0.000 description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 2
- 229930007744 linalool Natural products 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- 238000007726 management method Methods 0.000 description 2
- 229940041616 menthol Drugs 0.000 description 2
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 2
- HGBOYTHUEUWSSQ-UHFFFAOYSA-N pentanal Chemical compound CCCCC=O HGBOYTHUEUWSSQ-UHFFFAOYSA-N 0.000 description 2
- DTUQWGWMVIHBKE-UHFFFAOYSA-N phenylacetaldehyde Chemical compound O=CCC1=CC=CC=C1 DTUQWGWMVIHBKE-UHFFFAOYSA-N 0.000 description 2
- 239000002861 polymer material Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 235000013599 spices Nutrition 0.000 description 2
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
- 229940005605 valeric acid Drugs 0.000 description 2
- 229930007850 β-damascenone Natural products 0.000 description 2
- WTOYNNBCKUYIKC-JMSVASOKSA-N (+)-nootkatone Chemical compound C1C[C@@H](C(C)=C)C[C@@]2(C)[C@H](C)CC(=O)C=C21 WTOYNNBCKUYIKC-JMSVASOKSA-N 0.000 description 1
- GKTOAHZEMRRUKF-HVDRVSQOSA-N (2s)-2-aminopentanedioic acid;3-(1-methylpyrrolidin-2-yl)pyridine Chemical compound OC(=O)[C@@H](N)CCC(O)=O.CN1CCCC1C1=CC=CN=C1 GKTOAHZEMRRUKF-HVDRVSQOSA-N 0.000 description 1
- 229940098795 (3z)- 3-hexenyl acetate Drugs 0.000 description 1
- 239000001730 (5R)-5-butyloxolan-2-one Substances 0.000 description 1
- SKZDZXPBBYUFBY-WLHGVMLRSA-N (e)-but-2-enedioic acid;3-(1-methylpyrrolidin-2-yl)pyridine Chemical compound OC(=O)\C=C\C(O)=O.CN1CCCC1C1=CC=CN=C1 SKZDZXPBBYUFBY-WLHGVMLRSA-N 0.000 description 1
- 239000001363 2-ethyl-3,5-dimethylpyrazine Substances 0.000 description 1
- AIBWPBUAKCMKNS-PPHPATTJSA-N 2-hydroxybenzoic acid;3-[(2s)-1-methylpyrrolidin-2-yl]pyridine Chemical compound OC(=O)C1=CC=CC=C1O.CN1CCC[C@H]1C1=CC=CN=C1 AIBWPBUAKCMKNS-PPHPATTJSA-N 0.000 description 1
- SDVKWBNZJFWIMO-UHFFFAOYSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;3-(1-methylpyrrolidin-2-yl)pyridine Chemical compound CN1CCCC1C1=CC=CN=C1.OC(=O)CC(O)(C(O)=O)CC(O)=O SDVKWBNZJFWIMO-UHFFFAOYSA-N 0.000 description 1
- VWTHFJXLFGINSW-PPHPATTJSA-N 2-hydroxypropanoic acid;3-[(2s)-1-methylpyrrolidin-2-yl]pyridine Chemical compound CC(O)C(O)=O.CN1CCC[C@H]1C1=CC=CN=C1 VWTHFJXLFGINSW-PPHPATTJSA-N 0.000 description 1
- WLJVXDMOQOGPHL-PPJXEINESA-N 2-phenylacetic acid Chemical compound O[14C](=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-PPJXEINESA-N 0.000 description 1
- HDJBTCAJIMNXEW-PPHPATTJSA-N 3-[(2s)-1-methylpyrrolidin-2-yl]pyridine;hydrochloride Chemical compound Cl.CN1CCC[C@H]1C1=CC=CN=C1 HDJBTCAJIMNXEW-PPHPATTJSA-N 0.000 description 1
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 1
- 241000207199 Citrus Species 0.000 description 1
- 240000007154 Coffea arabica Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 244000004281 Eucalyptus maculata Species 0.000 description 1
- 239000005770 Eugenol Substances 0.000 description 1
- 241000208152 Geranium Species 0.000 description 1
- 240000004670 Glycyrrhiza echinata Species 0.000 description 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- 235000019501 Lemon oil Nutrition 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- HYMLWHLQFGRFIY-UHFFFAOYSA-N Maltol Natural products CC1OC=CC(=O)C1=O HYMLWHLQFGRFIY-UHFFFAOYSA-N 0.000 description 1
- YKVWPZJHENXDAJ-VOTSOKGWSA-N Megastigmatrienone Chemical compound CC1=CC(=O)CC(C)(C)C1\C=C\C=C YKVWPZJHENXDAJ-VOTSOKGWSA-N 0.000 description 1
- 235000006679 Mentha X verticillata Nutrition 0.000 description 1
- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 1
- 235000016639 Syzygium aromaticum Nutrition 0.000 description 1
- 244000223014 Syzygium aromaticum Species 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 235000009470 Theobroma cacao Nutrition 0.000 description 1
- 235000009499 Vanilla fragrans Nutrition 0.000 description 1
- 244000263375 Vanilla tahitensis Species 0.000 description 1
- 235000012036 Vanilla tahitensis Nutrition 0.000 description 1
- 244000273928 Zingiber officinale Species 0.000 description 1
- 235000006886 Zingiber officinale Nutrition 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 229940011037 anethole Drugs 0.000 description 1
- 229940009098 aspartate Drugs 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- POIARNZEYGURDG-UHFFFAOYSA-N beta-damascenone Natural products CC=CC(=O)C1=C(C)C=CCC1(C)C POIARNZEYGURDG-UHFFFAOYSA-N 0.000 description 1
- 239000008376 breath freshener Substances 0.000 description 1
- 239000004067 bulking agent Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- NPFVOOAXDOBMCE-PLNGDYQASA-N cis-3-Hexenyl acetate Natural products CC\C=C/CCOC(C)=O NPFVOOAXDOBMCE-PLNGDYQASA-N 0.000 description 1
- RRGOKSYVAZDNKR-ARJAWSKDSA-M cis-3-hexenylacetate Chemical compound CC\C=C/CCCC([O-])=O RRGOKSYVAZDNKR-ARJAWSKDSA-M 0.000 description 1
- 239000001926 citrus aurantium l. subsp. bergamia wright et arn. oil Substances 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 235000016213 coffee Nutrition 0.000 description 1
- 235000013353 coffee beverage Nutrition 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- WTOYNNBCKUYIKC-UHFFFAOYSA-N dl-nootkatone Natural products C1CC(C(C)=C)CC2(C)C(C)CC(=O)C=C21 WTOYNNBCKUYIKC-UHFFFAOYSA-N 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000003571 electronic cigarette Substances 0.000 description 1
- 229940073505 ethyl vanillin Drugs 0.000 description 1
- 229960002217 eugenol Drugs 0.000 description 1
- 238000005243 fluidization Methods 0.000 description 1
- IPBFYZQJXZJBFQ-UHFFFAOYSA-N gamma-octalactone Chemical compound CCCCC1CCC(=O)O1 IPBFYZQJXZJBFQ-UHFFFAOYSA-N 0.000 description 1
- 239000010648 geranium oil Substances 0.000 description 1
- 235000019717 geranium oil Nutrition 0.000 description 1
- 235000008397 ginger Nutrition 0.000 description 1
- 239000010649 ginger oil Substances 0.000 description 1
- 229960001867 guaiacol Drugs 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- -1 lactose or mannitol Chemical class 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 239000010501 lemon oil Substances 0.000 description 1
- 229940010454 licorice Drugs 0.000 description 1
- 229940043353 maltol Drugs 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229960001047 methyl salicylate Drugs 0.000 description 1
- 229940069688 nicotine bitartrate Drugs 0.000 description 1
- LDMPZNTVIGIREC-ZGPNLCEMSA-N nicotine bitartrate Chemical compound O.O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.CN1CCC[C@H]1C1=CC=CN=C1 LDMPZNTVIGIREC-ZGPNLCEMSA-N 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 229940100595 phenylacetaldehyde Drugs 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000012858 resilient material Substances 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 229930004725 sesquiterpene Natural products 0.000 description 1
- 150000004354 sesquiterpene derivatives Chemical class 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- PQDRXUSSKFWCFA-CFNZNRNTSA-N solanone Chemical compound CC(=O)CC[C@@H](C(C)C)\C=C\C(C)=C PQDRXUSSKFWCFA-CFNZNRNTSA-N 0.000 description 1
- PQDRXUSSKFWCFA-UHFFFAOYSA-N solanone Natural products CC(=O)CCC(C(C)C)C=CC(C)=C PQDRXUSSKFWCFA-UHFFFAOYSA-N 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- NPFVOOAXDOBMCE-UHFFFAOYSA-N trans-3-hexenyl acetate Natural products CCC=CCCOC(C)=O NPFVOOAXDOBMCE-UHFFFAOYSA-N 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
- A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/186—Treatment of tobacco products or tobacco substitutes by coating with a coating composition, encapsulation of tobacco particles
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
- A24B15/241—Extraction of specific substances
- A24B15/243—Nicotine
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F42/00—Simulated smoking devices other than electrically operated; Component parts thereof; Manufacture or testing thereof
- A24F42/20—Devices without heating means
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F42/00—Simulated smoking devices other than electrically operated; Component parts thereof; Manufacture or testing thereof
- A24F42/60—Constructional details
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F47/00—Smokers' requisites not otherwise provided for
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F7/00—Mouthpieces for pipes; Mouthpieces for cigar or cigarette holders
- A24F7/02—Mouthpieces for pipes; Mouthpieces for cigar or cigarette holders with detachable connecting members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
- A61M15/0035—Piercing means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0043—Non-destructive separation of the package, e.g. peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/06—Inhaling appliances shaped like cigars, cigarettes or pipes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
An inhaler system suitable for providing nicotine particles includes a mouthpiece portion removably coupled to a distal end portion. The mouthpiece portion includes a capsule cavity and a mouthpiece air channel extending from the mouthpiece end to the capsule cavity. The distal end portion includes a piercing element coupled to the distal end portion and a resealable membrane configured to seal the capsule cavity when the mouthpiece portion is coupled to the distal end portion. The resealable membrane is configured to reseal when the piercing element moves out of the resealable membrane.
Description
NICOTINE INHALER SYSTEM
This disclosure relates to a nicotine inhaler system that provides multi-use delivery of nicotine particles.
Nicotine particle inhalers are not always suitable to provide nicotine particles to the lungs at inhalation or air flow rates that are within conventional smoking regime inhalation or air flow rates. Nicotine particle inhalers do not always include nicotine particle consumable which is easily replaceable once consumed.
It is desirable to provide a nicotine inhaler system that provides multi-use delivery of .. nicotine particles. It is desirable that the nicotine inhaler system may include a modular component capsule receptacle that may be easily replaceable once consumed. It is desirable that the article facilitates delivery of nicotine particles to the consumer at conventional smoking regime inhalation or air flow rates. The nicotine inhaler system may alleviate one or more of the above mentioned problems.
This disclosure is directed to an inhaler system suitable for providing nicotine particles that includes a mouthpiece portion removably coupled to a distal end portion.
The mouthpiece portion includes a capsule cavity and a mouthpiece air channel extending from the mouthpiece end to the capsule cavity. The distal end portion includes a piercing element coupled to the distal end portion and a resealable membrane configured to seal the capsule cavity when the mouthpiece portion is coupled to the distal end portion. The resealable membrane is configured to reseal when the piercing element moves out of the resealable membrane.
The inhaler system suitable for providing nicotine particles may include an inhaler body extending from a mouthpiece end to a distal end and include a mouthpiece portion removably coupled to a distal end portion. The mouthpiece portion extends between the mouthpiece end and a first mating end. The distal end portion extends between a second mating end and the distal end. The mouthpiece portion includes a capsule cavity defined within the first mating end and a mouthpiece air channel extending from the mouthpiece end to the capsule cavity. The distal end portion includes a piercing element coupled to the distal end portion and a resealable membrane sealing the capsule cavity at the first mating end when the mouthpiece end is .. coupled to the distal end. The piercing element is configured to move between a relaxed
This disclosure relates to a nicotine inhaler system that provides multi-use delivery of nicotine particles.
Nicotine particle inhalers are not always suitable to provide nicotine particles to the lungs at inhalation or air flow rates that are within conventional smoking regime inhalation or air flow rates. Nicotine particle inhalers do not always include nicotine particle consumable which is easily replaceable once consumed.
It is desirable to provide a nicotine inhaler system that provides multi-use delivery of .. nicotine particles. It is desirable that the nicotine inhaler system may include a modular component capsule receptacle that may be easily replaceable once consumed. It is desirable that the article facilitates delivery of nicotine particles to the consumer at conventional smoking regime inhalation or air flow rates. The nicotine inhaler system may alleviate one or more of the above mentioned problems.
This disclosure is directed to an inhaler system suitable for providing nicotine particles that includes a mouthpiece portion removably coupled to a distal end portion.
The mouthpiece portion includes a capsule cavity and a mouthpiece air channel extending from the mouthpiece end to the capsule cavity. The distal end portion includes a piercing element coupled to the distal end portion and a resealable membrane configured to seal the capsule cavity when the mouthpiece portion is coupled to the distal end portion. The resealable membrane is configured to reseal when the piercing element moves out of the resealable membrane.
The inhaler system suitable for providing nicotine particles may include an inhaler body extending from a mouthpiece end to a distal end and include a mouthpiece portion removably coupled to a distal end portion. The mouthpiece portion extends between the mouthpiece end and a first mating end. The distal end portion extends between a second mating end and the distal end. The mouthpiece portion includes a capsule cavity defined within the first mating end and a mouthpiece air channel extending from the mouthpiece end to the capsule cavity. The distal end portion includes a piercing element coupled to the distal end portion and a resealable membrane sealing the capsule cavity at the first mating end when the mouthpiece end is .. coupled to the distal end. The piercing element is configured to move between a relaxed
- 2 -position and a piercing position. The piercing element extends into the capsule cavity in the piercing position. The resealable membrane is configured to reseal when the piercing element moves from the piercing position to the relaxed position.
Preferably a receptacle may be disposed within the capsule cavity. The receptacle being a replaceable article of the inhaler. The receptacle contains a capsule that may contain particles that include nicotine. The receptacle may be sealed with a membrane at a receptacle first end and define an air outlet at an opposing receptacle second end. The receptacle may include an air inlet. Air flow management through the inhaler system may cause the capsule to rotate and release nicotine particles (once pierced) into the airflow.
Preferably the resealable membrane contacts the receptacle first end. The resealable membrane may contact the membrane at a receptacle first end when the mouthpiece portion is couple to the distal end portion. The resealable membrane may prevent air flow into the receptacle first end through the membrane at a receptacle first end.
The receptacle and capsule article may be a modular component of the multi-use nicotine inhaler system. The article may be easily replaceable within the multi-use inhaler. Once consumed, the article may be removed from the multi-use inhaler and discarded.
Advantageously, the inhaler system described herein provides a re-usable modular component approach when combined with a consumable receptacle containing a capsule. The resealable membrane ensures the air flow path though the inhaler system originates from the air inlets and exits thorough the mouthpiece air channel. This air flow management ensures that the capsule may rotate during inhalation and consumption. This rotation may suspend and aerosolize the nicotine particles in the inhalation air moving through the inhaler system. The nicotine particles may be delivered with the inhaler at inhalation or air flow rates that are within conventional smoking regime inhalation or air flow rates.
The term "nicotine" refers to nicotine and nicotine derivatives such as free-base nicotine, nicotine salts and the like.
The term "flavourant" or "flavour" refers to organoleptic compounds, compositions, or materials that alter and are intended to alter the taste or aroma characteristics of nicotine during consumption or inhalation thereof. The term "flavourant" or "flavour"
preferably refers to
Preferably a receptacle may be disposed within the capsule cavity. The receptacle being a replaceable article of the inhaler. The receptacle contains a capsule that may contain particles that include nicotine. The receptacle may be sealed with a membrane at a receptacle first end and define an air outlet at an opposing receptacle second end. The receptacle may include an air inlet. Air flow management through the inhaler system may cause the capsule to rotate and release nicotine particles (once pierced) into the airflow.
Preferably the resealable membrane contacts the receptacle first end. The resealable membrane may contact the membrane at a receptacle first end when the mouthpiece portion is couple to the distal end portion. The resealable membrane may prevent air flow into the receptacle first end through the membrane at a receptacle first end.
The receptacle and capsule article may be a modular component of the multi-use nicotine inhaler system. The article may be easily replaceable within the multi-use inhaler. Once consumed, the article may be removed from the multi-use inhaler and discarded.
Advantageously, the inhaler system described herein provides a re-usable modular component approach when combined with a consumable receptacle containing a capsule. The resealable membrane ensures the air flow path though the inhaler system originates from the air inlets and exits thorough the mouthpiece air channel. This air flow management ensures that the capsule may rotate during inhalation and consumption. This rotation may suspend and aerosolize the nicotine particles in the inhalation air moving through the inhaler system. The nicotine particles may be delivered with the inhaler at inhalation or air flow rates that are within conventional smoking regime inhalation or air flow rates.
The term "nicotine" refers to nicotine and nicotine derivatives such as free-base nicotine, nicotine salts and the like.
The term "flavourant" or "flavour" refers to organoleptic compounds, compositions, or materials that alter and are intended to alter the taste or aroma characteristics of nicotine during consumption or inhalation thereof. The term "flavourant" or "flavour"
preferably refers to
- 3 -compounds disclosed in the Flavor & Extract Manufacturers Association (FEMA) Flavor Ingredient Library and in particular in the GRAS Flavoring Substances publications 3 to 27, for example, see Hall, R.L. & Oser, B.L., Food Technology, February 1965 pg 151-197, and in the GRAS flavoring substances 27 S.M. Cohen et al., Food Technology Aug. 2015 pg.
40-59, and intervening GRAS Flavoring Substances publications 4 to 26. For the purpose of this disclosure, nicotine is not considered as a flavourant or flavour.
The size of a particle, stated herein, preferably refers to the aerodynamic diameter of the particle. The aerodynamic diameter of the particles is preferably measured with a cascade impactor.
The inhaler system described herein may be combined with one or more modular nicotine particle delivery consumables to deliver the nicotine particles to a consumer. A plurality of these modular nicotine particle delivery consumables (similar of different formulation or flavors) may be combined with an inhaler system to form a kit.
An inhaler system includes a mouthpiece portion removably coupled to a distal end portion. The mouthpiece portion includes a capsule cavity and a mouthpiece air channel extending from the mouthpiece end to the capsule cavity. The distal end portion includes a piercing element coupled to the distal end portion and a resealable membrane configured to seal the capsule cavity when the mouthpiece portion is coupled to the distal end portion. The resealable membrane is configured to reseal when the piercing element moves out of the resealable membrane.
The inhaler system includes an inhaler body extending between a mouthpiece portion and a distal end portion. An inhaler receptacle cavity or capsule cavity may be defined within the inhaler body between the mouthpiece portion and the distal end portion. A
modular nicotine particle delivery consumable or receptacle article (receptacle containing a capsule containing particles including nicotine) may define an outer surface that mates with the inhaler receptacle cavity. A consumer may access the inhaler receptacle cavity to insert the modular receptacle article into the inhaler receptacle cavity or replace a depleted modular receptacle article with a full or un-used modular receptacle article into the inhaler receptacle cavity.
An air inlet may extend through the inhaler body and into the inhaler receptacle cavity. A
mouthpiece air channel
40-59, and intervening GRAS Flavoring Substances publications 4 to 26. For the purpose of this disclosure, nicotine is not considered as a flavourant or flavour.
The size of a particle, stated herein, preferably refers to the aerodynamic diameter of the particle. The aerodynamic diameter of the particles is preferably measured with a cascade impactor.
The inhaler system described herein may be combined with one or more modular nicotine particle delivery consumables to deliver the nicotine particles to a consumer. A plurality of these modular nicotine particle delivery consumables (similar of different formulation or flavors) may be combined with an inhaler system to form a kit.
An inhaler system includes a mouthpiece portion removably coupled to a distal end portion. The mouthpiece portion includes a capsule cavity and a mouthpiece air channel extending from the mouthpiece end to the capsule cavity. The distal end portion includes a piercing element coupled to the distal end portion and a resealable membrane configured to seal the capsule cavity when the mouthpiece portion is coupled to the distal end portion. The resealable membrane is configured to reseal when the piercing element moves out of the resealable membrane.
The inhaler system includes an inhaler body extending between a mouthpiece portion and a distal end portion. An inhaler receptacle cavity or capsule cavity may be defined within the inhaler body between the mouthpiece portion and the distal end portion. A
modular nicotine particle delivery consumable or receptacle article (receptacle containing a capsule containing particles including nicotine) may define an outer surface that mates with the inhaler receptacle cavity. A consumer may access the inhaler receptacle cavity to insert the modular receptacle article into the inhaler receptacle cavity or replace a depleted modular receptacle article with a full or un-used modular receptacle article into the inhaler receptacle cavity.
An air inlet may extend through the inhaler body and into the inhaler receptacle cavity. A
mouthpiece air channel
- 4 -is fluidly connected to the inhaler receptacle cavity and a proximal end of the mouthpiece. The inhaler body may resemble a smoking article or cigarette in size and shape.
In some embodiments, a capsule alone is inserted into the capsule cavity. A
consumer may access the inhaler capsule cavity to insert the capsule consumable into the inhaler capsule cavity or replace a capsule consumable with a full or un-used capsule consumable into the inhaler capsule cavity.
The air inlet or air inlets that extend through the inhaler body may mate or align with the air inlet or air inlets that extend through the sidewall of the receptacle article placed into the inhaler receptacle cavity. The modular receptacle article air outlet extending thought the .. receptacle second end may mate or align with the mouthpiece air channel of the inhaler body.
Once the modular receptacle article is placed into the inhaler receptacle cavity, air may flow through the modular receptacle article from the air inlet through the cavity and through the air outlet onto the mouthpiece air channel.
The resealable membrane may be fixed to the distal end and form a portion of the second mating end of the distal portion. The resealable membrane may separate the piercing element from the capsule cavity. The resealable membrane may contact the receptacle article when the mouthpiece portion is coupled to the distal portion. The resealable membrane may secure the receptacle article within the inhaler receptacle cavity. The resealable membrane may contact the membrane of the receptacle. The piercing element may pierce both the resealable .. membrane and the membrane of the receptacle when piercing the capsule contained within the receptacle article. When the piercing element moves back to its relaxed position and out of the resealable membrane, being spaced apart from the resealable membrane, the resealable membrane may reseal and prevent air from passing into the receptacle article through the void created in the membrane of the receptacle by the piercing element. Preferably the resealable membrane provides an air tight seal. The resealable membrane may provide an air tight seal after being pierced by the piercing element. The resealable membrane may provide an air tight seal while being pierced by the piercing element.
The distal portion is coupled to the piercing element. The distal portion may surround a portion of the piercing element. The piercing element may move along a longitudinal axis .. between a piercing (activated) position and a relaxed position. A biasing element may maintain the piercing element in the relaxed position. The biasing element may be a spring member. The
In some embodiments, a capsule alone is inserted into the capsule cavity. A
consumer may access the inhaler capsule cavity to insert the capsule consumable into the inhaler capsule cavity or replace a capsule consumable with a full or un-used capsule consumable into the inhaler capsule cavity.
The air inlet or air inlets that extend through the inhaler body may mate or align with the air inlet or air inlets that extend through the sidewall of the receptacle article placed into the inhaler receptacle cavity. The modular receptacle article air outlet extending thought the .. receptacle second end may mate or align with the mouthpiece air channel of the inhaler body.
Once the modular receptacle article is placed into the inhaler receptacle cavity, air may flow through the modular receptacle article from the air inlet through the cavity and through the air outlet onto the mouthpiece air channel.
The resealable membrane may be fixed to the distal end and form a portion of the second mating end of the distal portion. The resealable membrane may separate the piercing element from the capsule cavity. The resealable membrane may contact the receptacle article when the mouthpiece portion is coupled to the distal portion. The resealable membrane may secure the receptacle article within the inhaler receptacle cavity. The resealable membrane may contact the membrane of the receptacle. The piercing element may pierce both the resealable .. membrane and the membrane of the receptacle when piercing the capsule contained within the receptacle article. When the piercing element moves back to its relaxed position and out of the resealable membrane, being spaced apart from the resealable membrane, the resealable membrane may reseal and prevent air from passing into the receptacle article through the void created in the membrane of the receptacle by the piercing element. Preferably the resealable membrane provides an air tight seal. The resealable membrane may provide an air tight seal after being pierced by the piercing element. The resealable membrane may provide an air tight seal while being pierced by the piercing element.
The distal portion is coupled to the piercing element. The distal portion may surround a portion of the piercing element. The piercing element may move along a longitudinal axis .. between a piercing (activated) position and a relaxed position. A biasing element may maintain the piercing element in the relaxed position. The biasing element may be a spring member. The
- 5 -biasing element may compress when the piercing element is pressed into the piercing position.
Releasing the piercing element allows the biasing element to force the piercing element back to the relaxed position.
The piercing element may be a rigid element capable of piercing the resealable membrane and a capsule contained within the receptacle article or capsule cavity. The piercing element may be a metal element such as a needle.
The resealable membrane contacts the membrane of the receptacle and may effectively seal the void created in the membrane of the receptacle by the piercing element. Thus air flow through the inhaler system may not pass though the pierced membrane of the receptacle.
The resealable membrane is configured to close a void created in the resealable membrane created by a piercing element such as a needle. The resealable membrane may be pierced and seal or close the void a plurality of times, such as at least about 3 three times, or at least about 5 times, or at least about 10 times or at least about 20 times.
The void is created through the thickness of the resealable membrane. The resealable membrane may have a thickness in a range from about 0.1 to about 5 millimetres, or from about 0.5 to about 2 millimetres. The resealable membrane may be formed of any resilient material.
Resealable membranes may include a septum-like element. Resealable membranes may be formed of elastic material such as rubber, silicone, metal foil co-laminated with a polymer, or latex and the like.
The inhaler system includes a mouthpiece portion removably coupled to a distal end portion. The mouthpiece portion has a first mating end that fits or mates with a second mating end of the distal portion. The first mating end couples to the second mating end. The first mating portion may snap-fit to the second mating end. The first mating portion may screw onto or be in threaded engagement with the second mating end. The first mating portion may form an air tight fit or connection with the second mating end.
A modular receptacle article may be configured to be replacably disposed within the inhaler receptacle cavity or capsule cavity defined in the first mating end of the mouthpiece portion. The modular receptacle article includes a receptacle defining a cavity. A capsule is disposed within the cavity. The receptacle is configured to contain the capsule within the cavity.
The cavity may have a circular cross-section extending along at least a portion of the cavity
Releasing the piercing element allows the biasing element to force the piercing element back to the relaxed position.
The piercing element may be a rigid element capable of piercing the resealable membrane and a capsule contained within the receptacle article or capsule cavity. The piercing element may be a metal element such as a needle.
The resealable membrane contacts the membrane of the receptacle and may effectively seal the void created in the membrane of the receptacle by the piercing element. Thus air flow through the inhaler system may not pass though the pierced membrane of the receptacle.
The resealable membrane is configured to close a void created in the resealable membrane created by a piercing element such as a needle. The resealable membrane may be pierced and seal or close the void a plurality of times, such as at least about 3 three times, or at least about 5 times, or at least about 10 times or at least about 20 times.
The void is created through the thickness of the resealable membrane. The resealable membrane may have a thickness in a range from about 0.1 to about 5 millimetres, or from about 0.5 to about 2 millimetres. The resealable membrane may be formed of any resilient material.
Resealable membranes may include a septum-like element. Resealable membranes may be formed of elastic material such as rubber, silicone, metal foil co-laminated with a polymer, or latex and the like.
The inhaler system includes a mouthpiece portion removably coupled to a distal end portion. The mouthpiece portion has a first mating end that fits or mates with a second mating end of the distal portion. The first mating end couples to the second mating end. The first mating portion may snap-fit to the second mating end. The first mating portion may screw onto or be in threaded engagement with the second mating end. The first mating portion may form an air tight fit or connection with the second mating end.
A modular receptacle article may be configured to be replacably disposed within the inhaler receptacle cavity or capsule cavity defined in the first mating end of the mouthpiece portion. The modular receptacle article includes a receptacle defining a cavity. A capsule is disposed within the cavity. The receptacle is configured to contain the capsule within the cavity.
The cavity may have a circular cross-section extending along at least a portion of the cavity
6 length. The cavity may have a central axis or centroid longitudinal axis.
Preferably the cavity has a shape similar to the shape of the capsule. The cavity may have a circular cross-sectional shape and a first diameter and the capsule may have a second diameter that is less than the first diameter. The second diameter may be in a range from about 80% to about 99% of the first diameter, or the second diameter may be in a range from about 90% to about 98%
of the first diameter.
The receptacle includes a receptacle second end that is configured to contain the capsule and prevent the capsule from passing through the receptacle second end. The receptacle second end may be defined by a lateral wall integral with the body of the receptacle.
The receptacle second end may be defined by an end cap that is fixed to the body of the receptacle. One or more air outlets may extend through the receptacle second end to allow air to flow from the article cavity to the exterior of the receptacle.
A membrane may seal the receptacle first end. The capsule may be placed into the cavity of the receptacle through an open first end and then the membrane may seal the open first end to retain the capsule within the cavity of the article. The membrane may form a hermetic or airtight seal or barrier.
The membrane may be formed of a pierce-able material. The inhaler system piercing element passes through the membrane and punctures the capsule within the receptacle. The membrane may re-seal once the piercing element is retracted from the membrane.
Alternatively, the membrane may not re-seal once the piercing element is retracted from the membrane and be formed of resealable materials described herein. Membranes that may not re-seal include metal foil, for example.
An air inlet may extend through the receptacle body and into the cavity. Air inlets through the inhaler body may align with or be in air communication with the air inlets that extend through the receptacle body. Air inlets may be disposed on one or both of the inhaler body mouthpiece portion and distal portion. Preferably these air inlets are adjacent to or form part of the first or second mating ends. Air inlets that are on both the inhaler body mouthpiece portion and distal portion may align when the mouthpiece portion is coupled to the distal portion.
The cavity may have a length in a range from about 15 mm to about 25 mm or from about 20 mm to about 24 mm. The cavity may have an inner diameter in a range from about 5
Preferably the cavity has a shape similar to the shape of the capsule. The cavity may have a circular cross-sectional shape and a first diameter and the capsule may have a second diameter that is less than the first diameter. The second diameter may be in a range from about 80% to about 99% of the first diameter, or the second diameter may be in a range from about 90% to about 98%
of the first diameter.
The receptacle includes a receptacle second end that is configured to contain the capsule and prevent the capsule from passing through the receptacle second end. The receptacle second end may be defined by a lateral wall integral with the body of the receptacle.
The receptacle second end may be defined by an end cap that is fixed to the body of the receptacle. One or more air outlets may extend through the receptacle second end to allow air to flow from the article cavity to the exterior of the receptacle.
A membrane may seal the receptacle first end. The capsule may be placed into the cavity of the receptacle through an open first end and then the membrane may seal the open first end to retain the capsule within the cavity of the article. The membrane may form a hermetic or airtight seal or barrier.
The membrane may be formed of a pierce-able material. The inhaler system piercing element passes through the membrane and punctures the capsule within the receptacle. The membrane may re-seal once the piercing element is retracted from the membrane.
Alternatively, the membrane may not re-seal once the piercing element is retracted from the membrane and be formed of resealable materials described herein. Membranes that may not re-seal include metal foil, for example.
An air inlet may extend through the receptacle body and into the cavity. Air inlets through the inhaler body may align with or be in air communication with the air inlets that extend through the receptacle body. Air inlets may be disposed on one or both of the inhaler body mouthpiece portion and distal portion. Preferably these air inlets are adjacent to or form part of the first or second mating ends. Air inlets that are on both the inhaler body mouthpiece portion and distal portion may align when the mouthpiece portion is coupled to the distal portion.
The cavity may have a length in a range from about 15 mm to about 25 mm or from about 20 mm to about 24 mm. The cavity may have an inner diameter in a range from about 5
- 7 -mm to about 10 mm or from about 6 mm to about 8 mm. The cavity may have a length of about 20 mm and an inner diameter of about 6.6 mm when containing a capsule size 3 flat. The cavity may have a length of about 24 mm and an inner diameter of about 7.7 mm when containing a capsule size 1 flat.
The air inlet may be closer to the receptacle first end than the receptacle second end.
The air inlet may be located within about 5 mm or within about 4 mm or within about 3 mm or within about 2 mm of the receptacle first end. The air inlet may be located from about 1 mm to about 5 mm of the receptacle first end or from about 2 mm to about 4 mm of the receptacle first end.
The air inlet may be off-set from the centroid longitudinal (central) axis of the receptacle cavity or capsule contained within the cavity. The off-set air inlet induces the capsule to rotate or spin within the receptacle article during inhalation by the consumer. The air inlet may be off-set from the longitudinal (central) axis of the capsule or receptacle cavity by about 1 mm or about 2 mm or about 3 mm or about 4 mm where the cavity may have an inner diameter of about 5 mm to about 10 mm or from about 6 mm to about 8 mm. The one or more air inlets may have a diameter from about 0.5 to about 1.5 mm or about 0.7 mm to about 0.9 mm.
Preferably, the air inlet directs air tangentially to the outer diameter of the capsule contained within the receptacle article.
The receptacle article receptacle preferably has a circular cross-sectional shape extending (a length distance) along its central axis and forming a cylindrical receptacle.
Preferably the receptacle defines a right circular cylinder with a radius and having a length extending along a central axis. The air inlet may enter the receptacle tangentially to the cylindrical receptacle. Two or more air inlets enter the receptacle cavity tangentially to the cylindrical receptacle. Preferably these air inlets oppose each other and a first air inlet directs air tangentially to the cylindrical receptacle in a first direction and the second air inlet directs air tangentially to the cylindrical receptacle in a second direction that opposes or is in the opposite direction as the first direction. These opposing air inlets may direct inhalation air at opposing sides of the capsule contained within the receptacle promoting the rotation of the capsule contained within the receptacle.
The capsule may be sealed within the receptacle article prior to consumption or placement into the inhaler system. The receptacle article may be contained within a sealed or
The air inlet may be closer to the receptacle first end than the receptacle second end.
The air inlet may be located within about 5 mm or within about 4 mm or within about 3 mm or within about 2 mm of the receptacle first end. The air inlet may be located from about 1 mm to about 5 mm of the receptacle first end or from about 2 mm to about 4 mm of the receptacle first end.
The air inlet may be off-set from the centroid longitudinal (central) axis of the receptacle cavity or capsule contained within the cavity. The off-set air inlet induces the capsule to rotate or spin within the receptacle article during inhalation by the consumer. The air inlet may be off-set from the longitudinal (central) axis of the capsule or receptacle cavity by about 1 mm or about 2 mm or about 3 mm or about 4 mm where the cavity may have an inner diameter of about 5 mm to about 10 mm or from about 6 mm to about 8 mm. The one or more air inlets may have a diameter from about 0.5 to about 1.5 mm or about 0.7 mm to about 0.9 mm.
Preferably, the air inlet directs air tangentially to the outer diameter of the capsule contained within the receptacle article.
The receptacle article receptacle preferably has a circular cross-sectional shape extending (a length distance) along its central axis and forming a cylindrical receptacle.
Preferably the receptacle defines a right circular cylinder with a radius and having a length extending along a central axis. The air inlet may enter the receptacle tangentially to the cylindrical receptacle. Two or more air inlets enter the receptacle cavity tangentially to the cylindrical receptacle. Preferably these air inlets oppose each other and a first air inlet directs air tangentially to the cylindrical receptacle in a first direction and the second air inlet directs air tangentially to the cylindrical receptacle in a second direction that opposes or is in the opposite direction as the first direction. These opposing air inlets may direct inhalation air at opposing sides of the capsule contained within the receptacle promoting the rotation of the capsule contained within the receptacle.
The capsule may be sealed within the receptacle article prior to consumption or placement into the inhaler system. The receptacle article may be contained within a sealed or
- 8 -airtight container or bag. The receptacle article may include one or more peelable seal layers to cover the one or more air inlets or one or more air outlets on the receptacle article. An air outlet seal layer may be disposed on the air outlet. This seal layer may be configured to be punctured or be peelable to expose the air outlet. An air inlet seal layer may be disposed on the air inlet.
This seal layer may be configured to be punctured or be peelable to expose the air inlet. The inhaler system may include air inlet piercing element or an air outlet piercing element that are configured to puncture one or both of these seal layers upon insertion of the receptacle article into the inhaler receptacle cavity or upon activation of the inhaler.
The capsule may be configured to rotate about its' longitudinal or central axis when air .. flows through the inhaler system (from the air inlet through the receptacle to the air outlet). The capsule may be formed of an airtight material that may be pierced or punctured by the piercing element of the inhaler system. The capsule may formed of a metallic or polymeric material that serves to keep contaminates out of the capsule but may be pierced or punctured by a piercing element prior to consumption of the nicotine particles within the capsule.
Preferably, the capsule is formed of a polymer material. The polymer material may be hydroxypropylmethylcellulose (HPMC). Preferably, the capsule is a size 1 to size 4 or a size 3 capsule.
The capsule contains solid nicotine particles (also referred to as "nicotine powder" or "particles comprising nicotine") and optional flavour particles. The capsule may contain a predetermined amount of nicotine particles and optional flavour particles. The capsule may contain enough nicotine particles to provide at least 2 inhalations or "puffs", or at least about 5 inhalations or "puffs", or at least about 10 inhalations or "puffs".
Preferably, the capsule may contain enough nicotine particles to provide from about 5 to 50 inhalations or "puffs", or from about 10 to 30 inhalations or "puffs". Each inhalation or "puff' may deliver from about 0.1 mg to about 3 mg of nicotine particles to the lungs of the user or from about 0.2 mg to about 2 mg of .. nicotine particles to the lungs of the user or about 1 mg of nicotine particles to the lungs of the user.
The nicotine particles may have any useful concentration of nicotine based on the particular formulation employed. The nicotine particles may have at least about 5%wt nicotine up to about 30%wt, or from about 5%wt to about 25%wt, or from about 5%wt to about 20%wt, or from about 5%wt to about 15%wt, or from about 7%wt to about 13%wt, nicotine. Preferably,
This seal layer may be configured to be punctured or be peelable to expose the air inlet. The inhaler system may include air inlet piercing element or an air outlet piercing element that are configured to puncture one or both of these seal layers upon insertion of the receptacle article into the inhaler receptacle cavity or upon activation of the inhaler.
The capsule may be configured to rotate about its' longitudinal or central axis when air .. flows through the inhaler system (from the air inlet through the receptacle to the air outlet). The capsule may be formed of an airtight material that may be pierced or punctured by the piercing element of the inhaler system. The capsule may formed of a metallic or polymeric material that serves to keep contaminates out of the capsule but may be pierced or punctured by a piercing element prior to consumption of the nicotine particles within the capsule.
Preferably, the capsule is formed of a polymer material. The polymer material may be hydroxypropylmethylcellulose (HPMC). Preferably, the capsule is a size 1 to size 4 or a size 3 capsule.
The capsule contains solid nicotine particles (also referred to as "nicotine powder" or "particles comprising nicotine") and optional flavour particles. The capsule may contain a predetermined amount of nicotine particles and optional flavour particles. The capsule may contain enough nicotine particles to provide at least 2 inhalations or "puffs", or at least about 5 inhalations or "puffs", or at least about 10 inhalations or "puffs".
Preferably, the capsule may contain enough nicotine particles to provide from about 5 to 50 inhalations or "puffs", or from about 10 to 30 inhalations or "puffs". Each inhalation or "puff' may deliver from about 0.1 mg to about 3 mg of nicotine particles to the lungs of the user or from about 0.2 mg to about 2 mg of .. nicotine particles to the lungs of the user or about 1 mg of nicotine particles to the lungs of the user.
The nicotine particles may have any useful concentration of nicotine based on the particular formulation employed. The nicotine particles may have at least about 5%wt nicotine up to about 30%wt, or from about 5%wt to about 25%wt, or from about 5%wt to about 20%wt, or from about 5%wt to about 15%wt, or from about 7%wt to about 13%wt, nicotine. Preferably,
- 9 -about 50 to about 150 micrograms of nicotine is delivered to the lungs of the user with each "puff,.
The capsule may hold or contain at least about 5 mg of nicotine particles or at least about 10 mg of nicotine particles. Preferably, the capsule holds or contains less than about 900 mg of nicotine particles, or less than about 300 mg of nicotine particles, or less than 150 mg of nicotine particles. The capsule may hold or contain from about 5 mg to about 300 mg of nicotine particles or from about 10 mg to about 200 mg of nicotine particles.
When flavour particles are blended or combined with the nicotine particles within the capsule, the flavour particles are present in an amount that provides the desired flavour to each inhalation or "puff" delivered to the user.
The nicotine particles may have any useful size distribution for inhalation delivery preferentially into the lungs of a user. The capsule may include other particles than the nicotine particles. The nicotine particles and the other particles form a powder system.
The capsule may hold or contain at least about 5 mg of a powder system or at least about 10 mg of a powder system. Preferably, the capsule holds or contains less than about 900 mg of a powder system, or less than about 300 mg of a powder system, or less than 150 mg of a powder system. The capsule may hold or contain from about 5 mg to about 300 mg of a powder system or from about 10 mg to about 200 mg of a powder system.
The powder system may have at least about 40% or at least about 60%, or at least about 80%, by weight of the powder system comprised in nicotine particles having a particle size of about 10 micrometres or less, or 5 micrometers or less, or in a range from about 1 micrometer to about 3 micrometres.
Nicotine in the powder system or nicotine particles is preferably a pharmaceutically acceptable free-base nicotine, or nicotine salt or nicotine salt hydrate.
Useful nicotine salts or nicotine salt hydrates include nicotine pyruvate, nicotine citrate, nicotine aspartate, nicotine lactate, nicotine bitartrate, nicotine salicylate, nicotine fumarate, nicotine mono-pyruvate, nicotine glutamate or nicotine hydrochloride, for example. The compound combining with nicotine to form the salt or salt hydrate may be chosen based on its expected pharmacological effect.
The capsule may hold or contain at least about 5 mg of nicotine particles or at least about 10 mg of nicotine particles. Preferably, the capsule holds or contains less than about 900 mg of nicotine particles, or less than about 300 mg of nicotine particles, or less than 150 mg of nicotine particles. The capsule may hold or contain from about 5 mg to about 300 mg of nicotine particles or from about 10 mg to about 200 mg of nicotine particles.
When flavour particles are blended or combined with the nicotine particles within the capsule, the flavour particles are present in an amount that provides the desired flavour to each inhalation or "puff" delivered to the user.
The nicotine particles may have any useful size distribution for inhalation delivery preferentially into the lungs of a user. The capsule may include other particles than the nicotine particles. The nicotine particles and the other particles form a powder system.
The capsule may hold or contain at least about 5 mg of a powder system or at least about 10 mg of a powder system. Preferably, the capsule holds or contains less than about 900 mg of a powder system, or less than about 300 mg of a powder system, or less than 150 mg of a powder system. The capsule may hold or contain from about 5 mg to about 300 mg of a powder system or from about 10 mg to about 200 mg of a powder system.
The powder system may have at least about 40% or at least about 60%, or at least about 80%, by weight of the powder system comprised in nicotine particles having a particle size of about 10 micrometres or less, or 5 micrometers or less, or in a range from about 1 micrometer to about 3 micrometres.
Nicotine in the powder system or nicotine particles is preferably a pharmaceutically acceptable free-base nicotine, or nicotine salt or nicotine salt hydrate.
Useful nicotine salts or nicotine salt hydrates include nicotine pyruvate, nicotine citrate, nicotine aspartate, nicotine lactate, nicotine bitartrate, nicotine salicylate, nicotine fumarate, nicotine mono-pyruvate, nicotine glutamate or nicotine hydrochloride, for example. The compound combining with nicotine to form the salt or salt hydrate may be chosen based on its expected pharmacological effect.
- 10 -The nicotine particles preferably include an amino acid. Preferably the amino acid is leucine such as, L-leucine. Providing an amino acid such as L-leucine with the particles comprising nicotine, may reduce adhesion forces of the particles comprising nicotine and may reduce attraction between nicotine particles and thus reduce agglomeration of nicotine particles.
Similarly, adhesion forces to particles comprising flavour is also reduced thus agglomeration of nicotine particles with flavour particles is also reduced.
The powder system described herein thus may be a free flowing material and possess a stable relative particle size of each powder component even when the nicotine particles and the flavour particles are combined.
The powder system may include flavour particles. The flavour particles may have any useful size distribution for inhalation delivery selectively into the mouth or buccal cavity of a user.
The powder system may have at least about 40%, or at least about 60%, or at least about 80%, by weight of the flavour of the powder system comprised in particles having a __ particle size of about 20 micrometres or greater. The powder system may have at least about 40% or at least about 60%, or at least about 80%, by weight of the flavour of the powder system comprised in particles having a particle size of about 50 micrometres or greater. The powder system may have at least about 40% or at least about 60%, or at least about 80%, by weight of the flavour of the powder system comprised in particles having a particle size in a range from __ about 50 micrometer to about 150 micrometres.
Flavourants or flavours may be provided as a solid flavour (at room temperature of about 22 degrees centigrade and one atmosphere pressure) and may include flavour formulations, flavour-containing materials and flavour precursors. The flavourant may include one or more natural flavourants, one or more synthetic flavourants, or a combination of natural and synthetic __ flavourants. Flavourants as described herein are organoleptic compounds, compositions, or materials that are selected and utilized to alter or are intended to alter the taste or aroma characteristics of the nicotine component during consumption or inhalation thereof.
Flavourants or flavours refer to a variety of flavour materials of natural or synthetic origin.
They include single compounds and mixtures. Preferably the flavour or flavourant has flavour
Similarly, adhesion forces to particles comprising flavour is also reduced thus agglomeration of nicotine particles with flavour particles is also reduced.
The powder system described herein thus may be a free flowing material and possess a stable relative particle size of each powder component even when the nicotine particles and the flavour particles are combined.
The powder system may include flavour particles. The flavour particles may have any useful size distribution for inhalation delivery selectively into the mouth or buccal cavity of a user.
The powder system may have at least about 40%, or at least about 60%, or at least about 80%, by weight of the flavour of the powder system comprised in particles having a __ particle size of about 20 micrometres or greater. The powder system may have at least about 40% or at least about 60%, or at least about 80%, by weight of the flavour of the powder system comprised in particles having a particle size of about 50 micrometres or greater. The powder system may have at least about 40% or at least about 60%, or at least about 80%, by weight of the flavour of the powder system comprised in particles having a particle size in a range from __ about 50 micrometer to about 150 micrometres.
Flavourants or flavours may be provided as a solid flavour (at room temperature of about 22 degrees centigrade and one atmosphere pressure) and may include flavour formulations, flavour-containing materials and flavour precursors. The flavourant may include one or more natural flavourants, one or more synthetic flavourants, or a combination of natural and synthetic __ flavourants. Flavourants as described herein are organoleptic compounds, compositions, or materials that are selected and utilized to alter or are intended to alter the taste or aroma characteristics of the nicotine component during consumption or inhalation thereof.
Flavourants or flavours refer to a variety of flavour materials of natural or synthetic origin.
They include single compounds and mixtures. Preferably the flavour or flavourant has flavour
- 11 -properties that enhance the experience of the nicotine component during consumption.
Preferably, the flavour is chosen to provide an experience similar to that resulting from smoking a combustible smoking article. For example, the flavour or flavourant may enhance flavour properties such as mouth fullness and complexity. Complexity is generally known as the overall __ balance of the flavour being richer without dominating single sensory attributes. Mouth fullness is described as perception of richness and volume in the mouth and throat of the consumer.
Suitable flavours include, but are not limited to, any natural or synthetic flavour, such as tobacco, smoke, menthol, mint (such as peppermint and spearmint), chocolate, licorice, citrus and other fruit flavours, gamma octalactone, vanillin, ethyl vanillin, breath freshener flavours, __ spice flavours such as cinnamon, methyl salicylate, linalool, bergamot oil, geranium oil, lemon oil, and ginger oil, and the like.
Other suitable flavours may include flavour compounds selected from the group consisting of an acid, an alcohol, an ester, an aldehyde, a ketone, a pyrazine, combinations or blends thereof and the like. Suitable flavour compounds may be selected, for example, from the group consisting of phenylacetic acid, solanone, megastigmatrienone, 2-heptanone, benzylalcohol, cis-3-hexenyl acetate, valeric acid, valeric aldehyde, ester, terpene, sesquiterpene, nootkatone, maltol, damascenone, pyrazine, lactone, anethole, iso-s valeric acid, combinations thereof, and the like.
Further specific examples of flavours may be found in the current literature, and are well-__ known to the person skilled in the art of flavouring, i.e. of imparting an odor or taste to a product.
The flavourant may be a high potency flavourant, and may be used and detected at levels that would result in less than 200 parts per million in inhalation air flow. Examples of such flavourants are key tobacco aroma compounds such as beta-damascenone, 2-ethyl-3,5-dimethylpyrazine, phenylacetaldehyde, guaiacol, and furaneol. Other flavourants may only be __ sensed by humans at higher concentration levels. These flavourants, which are referred to herein as the lower potency flavourants, are typically used at levels that results in orders of magnitude higher amounts of flavourant released into the inhalation air.
Suitable lower potency flavourants include, but are not limited to, natural or synthetic menthol, peppermint, spearmint, coffee, tea, spices (such as cinnamon, clove and ginger), cocoa, vanilla, fruit flavours, __ chocolate, eucalyptus, geranium, eugenol and linalool.
Preferably, the flavour is chosen to provide an experience similar to that resulting from smoking a combustible smoking article. For example, the flavour or flavourant may enhance flavour properties such as mouth fullness and complexity. Complexity is generally known as the overall __ balance of the flavour being richer without dominating single sensory attributes. Mouth fullness is described as perception of richness and volume in the mouth and throat of the consumer.
Suitable flavours include, but are not limited to, any natural or synthetic flavour, such as tobacco, smoke, menthol, mint (such as peppermint and spearmint), chocolate, licorice, citrus and other fruit flavours, gamma octalactone, vanillin, ethyl vanillin, breath freshener flavours, __ spice flavours such as cinnamon, methyl salicylate, linalool, bergamot oil, geranium oil, lemon oil, and ginger oil, and the like.
Other suitable flavours may include flavour compounds selected from the group consisting of an acid, an alcohol, an ester, an aldehyde, a ketone, a pyrazine, combinations or blends thereof and the like. Suitable flavour compounds may be selected, for example, from the group consisting of phenylacetic acid, solanone, megastigmatrienone, 2-heptanone, benzylalcohol, cis-3-hexenyl acetate, valeric acid, valeric aldehyde, ester, terpene, sesquiterpene, nootkatone, maltol, damascenone, pyrazine, lactone, anethole, iso-s valeric acid, combinations thereof, and the like.
Further specific examples of flavours may be found in the current literature, and are well-__ known to the person skilled in the art of flavouring, i.e. of imparting an odor or taste to a product.
The flavourant may be a high potency flavourant, and may be used and detected at levels that would result in less than 200 parts per million in inhalation air flow. Examples of such flavourants are key tobacco aroma compounds such as beta-damascenone, 2-ethyl-3,5-dimethylpyrazine, phenylacetaldehyde, guaiacol, and furaneol. Other flavourants may only be __ sensed by humans at higher concentration levels. These flavourants, which are referred to herein as the lower potency flavourants, are typically used at levels that results in orders of magnitude higher amounts of flavourant released into the inhalation air.
Suitable lower potency flavourants include, but are not limited to, natural or synthetic menthol, peppermint, spearmint, coffee, tea, spices (such as cinnamon, clove and ginger), cocoa, vanilla, fruit flavours, __ chocolate, eucalyptus, geranium, eugenol and linalool.
- 12 -The particles comprising flavour may include a compound to reduce adhesion forces or surface energy and resulting agglomeration. The flavour particle may be surface modified with an adhesion reducing compound to form a coated flavour particle. One preferred adhesion reducing compound is magnesium stearate. Providing an adhesion reducing compound such as magnesium stearate with the flavour particle, especially coating the flavour particle, reduces adhesion forces of the particles comprising flavour and may reduce attraction between flavour particles and thus reduce agglomeration of flavour particles. Thus agglomeration of flavour particles with nicotine particles is also reduced. The powder system described herein thus may possess a stable relative particle size of the particles comprising nicotine and the particles comprising flavour even when the nicotine particles and the flavour particles are combined. The powder system preferably is free flowing.
Conventional formulations for dry powder inhalation typically contain carrier particles that serve to increase the fluidization of the active particles since the active particles may be too small to be influenced by simple airflow though the inhaler. The powder system may comprise carrier particles. These carrier particles may be a saccharide such as lactose or mannitol that have a particle size greater than about 50 micrometres. The carrier particles may be utilized to improve dose uniformity by acting as a diluent or bulking agent in a formulation.
The powder system utilized with the nicotine powder delivery system described herein may be carrier-free or substantially free of a saccharide such as lactose or mannitol. Being carrier-free or substantially free of a saccharide such as lactose or mannitol may allow the nicotine and to be inhaled and delivered to the user's lungs at inhalation or airflow rates that are similar to typical smoking regime inhalation or airflow rates. In addition, since the nicotine is carrier-free or substantially free of a saccharide such as lactose or mannitol, the airflow path of the inhaler may have simple geometry or a simple configuration.
The nicotine powder and a flavour may be combined in a single capsule. As described above, the nicotine powder and a flavour may each have reduced adhesion forces that result in a stable powder formulation where the particle size of each component does not substantially change when combined.
The nicotine particles and flavour particles may be combined in any useful relative amount so that the flavour particles are detected by the user when consumed with the nicotine
Conventional formulations for dry powder inhalation typically contain carrier particles that serve to increase the fluidization of the active particles since the active particles may be too small to be influenced by simple airflow though the inhaler. The powder system may comprise carrier particles. These carrier particles may be a saccharide such as lactose or mannitol that have a particle size greater than about 50 micrometres. The carrier particles may be utilized to improve dose uniformity by acting as a diluent or bulking agent in a formulation.
The powder system utilized with the nicotine powder delivery system described herein may be carrier-free or substantially free of a saccharide such as lactose or mannitol. Being carrier-free or substantially free of a saccharide such as lactose or mannitol may allow the nicotine and to be inhaled and delivered to the user's lungs at inhalation or airflow rates that are similar to typical smoking regime inhalation or airflow rates. In addition, since the nicotine is carrier-free or substantially free of a saccharide such as lactose or mannitol, the airflow path of the inhaler may have simple geometry or a simple configuration.
The nicotine powder and a flavour may be combined in a single capsule. As described above, the nicotine powder and a flavour may each have reduced adhesion forces that result in a stable powder formulation where the particle size of each component does not substantially change when combined.
The nicotine particles and flavour particles may be combined in any useful relative amount so that the flavour particles are detected by the user when consumed with the nicotine
- 13 -particles. Preferably the nicotine particles and a flavour particles form at least about 90%wt or at least about 95%wt or at least about 99%wt or 100%wt of the total weight of the powder system.
The inhaler systems described herein are less complex and have a simplified storage and airflow path as compared to conventional dry powder inhalers.
Advantageously, rotation of the capsule within the inhaler system aerosolizes the nicotine particles or powder system and may assist in maintaining a free flowing powder. Thus, this inhaler system does not require the typical high inhalation rates of conventional inhalers to deliver the nicotine particles described above deep into the lungs.
The inhaler system may use a flow rate of less than about 5 Umin or less than about 3 Umin or less than about 2 Umin or about 1.6 Umin. Preferably, the flow rate is in a range from about 1 Umin to about 3 Umin or from about 1.5 Umin to about 2.5 Umin.
Preferably, the inhalation rate or flow rate is similar to that of Health Canada smoking regime, that is, about 1.6 Umin.
The inhaler system may be used by a consumer like smoking a conventional cigarette or vaping an electronic cigarette. Such smoking or vaping is characterized by two steps: a first step during which a small volume containing the full amount of nicotine desired by the consumer is drawn into the mouth cavity, followed by a second step during which this small volume comprising the aerosol comprising the desired amount of nicotine is further diluted by fresh air and drawn deeper into the lungs. Both steps are controlled by the consumer.
During the first inhalation step the consumer may determine the amount of nicotine to be inhaled. During the second step, the consumer may determine the volume for diluting the first volume to be drawn deeper into the lungs, maximizing the concentration of active agent delivered to the airway epithelial surface. This smoking mechanism is sometimes called "puff-inhale-exhale".
All scientific and technical terms used herein have meanings commonly used in the art unless otherwise specified. The definitions provided herein are to facilitate understanding of certain terms used frequently herein.
The terms "upstream" and "downstream" refer to relative positions of elements of the inhaler described in relation to the direction of inhalation air flow as it is drawn through the body of the inhaler from a distal end portion to the mouthpiece portion.
The inhaler systems described herein are less complex and have a simplified storage and airflow path as compared to conventional dry powder inhalers.
Advantageously, rotation of the capsule within the inhaler system aerosolizes the nicotine particles or powder system and may assist in maintaining a free flowing powder. Thus, this inhaler system does not require the typical high inhalation rates of conventional inhalers to deliver the nicotine particles described above deep into the lungs.
The inhaler system may use a flow rate of less than about 5 Umin or less than about 3 Umin or less than about 2 Umin or about 1.6 Umin. Preferably, the flow rate is in a range from about 1 Umin to about 3 Umin or from about 1.5 Umin to about 2.5 Umin.
Preferably, the inhalation rate or flow rate is similar to that of Health Canada smoking regime, that is, about 1.6 Umin.
The inhaler system may be used by a consumer like smoking a conventional cigarette or vaping an electronic cigarette. Such smoking or vaping is characterized by two steps: a first step during which a small volume containing the full amount of nicotine desired by the consumer is drawn into the mouth cavity, followed by a second step during which this small volume comprising the aerosol comprising the desired amount of nicotine is further diluted by fresh air and drawn deeper into the lungs. Both steps are controlled by the consumer.
During the first inhalation step the consumer may determine the amount of nicotine to be inhaled. During the second step, the consumer may determine the volume for diluting the first volume to be drawn deeper into the lungs, maximizing the concentration of active agent delivered to the airway epithelial surface. This smoking mechanism is sometimes called "puff-inhale-exhale".
All scientific and technical terms used herein have meanings commonly used in the art unless otherwise specified. The definitions provided herein are to facilitate understanding of certain terms used frequently herein.
The terms "upstream" and "downstream" refer to relative positions of elements of the inhaler described in relation to the direction of inhalation air flow as it is drawn through the body of the inhaler from a distal end portion to the mouthpiece portion.
- 14 -As used herein, the singular forms "a", "an", and "the" encompass embodiments having plural referents, unless the content clearly dictates otherwise.
As used herein, "or" is generally employed in its sense including "and/or"
unless the content clearly dictates otherwise. The term "and/or" means one or all of the listed elements or a combination of any two or more of the listed elements.
As used herein, "have", "having", "include", "including", "comprise", "comprising" or the like are used in their open ended sense, and generally mean "including, but not limited to". It will be understood that "consisting essentially of", "consisting of", and the like are subsumed in "comprising," and the like.
, The words "preferred" and "preferably" refer to embodiments of the invention that may afford certain benefits, under certain circumstances. However, other embodiments may also be preferred, under the same or other circumstances. Furthermore, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful, and is not intended to exclude other embodiments from the scope of the disclosure, including the claims.
The schematic drawings are not necessarily to scale and are presented for purposes of illustration and not limitation. The drawings depict one or more aspects described in this disclosure. However, it will be understood that other aspects not depicted in the drawing fall within the scope and spirit of this disclosure.
Referring to FIG. 1, an inhaler system 10 includes a mouthpiece portion 20 removably coupled to a distal end portion 30. The mouthpiece portion 20 includes a capsule cavity 26 and a mouthpiece air channel 25 extending from the mouthpiece end 22 to the capsule cavity 26. A
capsule cavity outlet air channel 23 couples the mouthpiece air channel 25 to the capsule cavity 26. The capsule cavity 26 is defined by a cavity wall 26. The distal end portion 30 includes a piercing element 36 coupled to the distal end portion 30 and a resealable membrane 40 configured to seal the capsule cavity 26 when the mouthpiece portion 20 is coupled to the distal end portion 30. The resealable membrane 40 is configured to reseal when the piercing element 36 or needle 37 moves out of the resealable membrane 40. One or more air inlets 28 pass through the cavity wall 26.
As used herein, "or" is generally employed in its sense including "and/or"
unless the content clearly dictates otherwise. The term "and/or" means one or all of the listed elements or a combination of any two or more of the listed elements.
As used herein, "have", "having", "include", "including", "comprise", "comprising" or the like are used in their open ended sense, and generally mean "including, but not limited to". It will be understood that "consisting essentially of", "consisting of", and the like are subsumed in "comprising," and the like.
, The words "preferred" and "preferably" refer to embodiments of the invention that may afford certain benefits, under certain circumstances. However, other embodiments may also be preferred, under the same or other circumstances. Furthermore, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful, and is not intended to exclude other embodiments from the scope of the disclosure, including the claims.
The schematic drawings are not necessarily to scale and are presented for purposes of illustration and not limitation. The drawings depict one or more aspects described in this disclosure. However, it will be understood that other aspects not depicted in the drawing fall within the scope and spirit of this disclosure.
Referring to FIG. 1, an inhaler system 10 includes a mouthpiece portion 20 removably coupled to a distal end portion 30. The mouthpiece portion 20 includes a capsule cavity 26 and a mouthpiece air channel 25 extending from the mouthpiece end 22 to the capsule cavity 26. A
capsule cavity outlet air channel 23 couples the mouthpiece air channel 25 to the capsule cavity 26. The capsule cavity 26 is defined by a cavity wall 26. The distal end portion 30 includes a piercing element 36 coupled to the distal end portion 30 and a resealable membrane 40 configured to seal the capsule cavity 26 when the mouthpiece portion 20 is coupled to the distal end portion 30. The resealable membrane 40 is configured to reseal when the piercing element 36 or needle 37 moves out of the resealable membrane 40. One or more air inlets 28 pass through the cavity wall 26.
- 15 -FIG 2 is a schematic diagram of another illustrative inhaler system 10 with the distal end portion 30 un-coupled from the mouthpiece portion 20 and a nicotine powder delivery consumable 100 or receptacle article disposed within the capsule cavity 26.
FIG. 3 is schematic diagram the illustrative inhaler system 10 with the distal end portion 30 coupled from the .. mouthpiece portion 20 and containing a capsule 120 within a receptacle article 100. FIG. 4 is schematic diagram the illustrative inhaler system 10 with the piercing element 36, 37 piercing the capsule 120 within a receptacle article 100 and piercing the resealable membrane 40.
The inhaler system 10 may include an inhaler body 12 extending from a mouthpiece end 22 to a distal end 32 and include a mouthpiece portion 20 removably coupled to a distal end portion 30. The mouthpiece portion 20 extends between the mouthpiece end 22 and a first mating end 24. The distal end portion 30 extends between a second mating end 34 and the distal end 32. The mouthpiece portion 20 includes a capsule cavity 26 defined within the first mating end 24 and a mouthpiece air channel 25 extending from the mouthpiece end 22 to the capsule cavity 26. A capsule cavity outlet air channel 23 couples the mouthpiece air channel 25 to the capsule cavity 26.
The distal end portion 30 includes a piercing element 36 coupled to the distal end portion 30 and a resealable membrane 40 sealing the capsule cavity 26 at the first mating end 24 when the mouthpiece end 20 is coupled to the distal end 30. The piercing element 36 is configured to move between a relaxed position (FIG. 3) and a piercing position (FIG. 4). The piercing element 37 extends into the capsule cavity 28 or 116 in the piercing position. The resealable membrane 40 is configured to reseal when the piercing element 37 moves from the piercing position to the relaxed position. A biasing element 31 or spring may provide the force to return the piercing element 36 to the relaxed position.
One or more air inlets 28, 38 on the inhaler body may align to provide inlet air to the capsule cavity 28. The one or more air inlets 28, 38 may extend through a side wall forming the capsule cavity 26. The air inlets 28, 38 may align with or be in air communication with the air inlets 117 of the receptacle article 100. The receptacle cavity 26 is configured to mate with the receptacle article 100. The detachable distal portion 30 may be removed from the mouthpiece portion 20 to expose the receptacle cavity 26 to replace the modular and used or depleted receptacle article 100 with an un-used or full receptacle article 100.
FIG. 3 is schematic diagram the illustrative inhaler system 10 with the distal end portion 30 coupled from the .. mouthpiece portion 20 and containing a capsule 120 within a receptacle article 100. FIG. 4 is schematic diagram the illustrative inhaler system 10 with the piercing element 36, 37 piercing the capsule 120 within a receptacle article 100 and piercing the resealable membrane 40.
The inhaler system 10 may include an inhaler body 12 extending from a mouthpiece end 22 to a distal end 32 and include a mouthpiece portion 20 removably coupled to a distal end portion 30. The mouthpiece portion 20 extends between the mouthpiece end 22 and a first mating end 24. The distal end portion 30 extends between a second mating end 34 and the distal end 32. The mouthpiece portion 20 includes a capsule cavity 26 defined within the first mating end 24 and a mouthpiece air channel 25 extending from the mouthpiece end 22 to the capsule cavity 26. A capsule cavity outlet air channel 23 couples the mouthpiece air channel 25 to the capsule cavity 26.
The distal end portion 30 includes a piercing element 36 coupled to the distal end portion 30 and a resealable membrane 40 sealing the capsule cavity 26 at the first mating end 24 when the mouthpiece end 20 is coupled to the distal end 30. The piercing element 36 is configured to move between a relaxed position (FIG. 3) and a piercing position (FIG. 4). The piercing element 37 extends into the capsule cavity 28 or 116 in the piercing position. The resealable membrane 40 is configured to reseal when the piercing element 37 moves from the piercing position to the relaxed position. A biasing element 31 or spring may provide the force to return the piercing element 36 to the relaxed position.
One or more air inlets 28, 38 on the inhaler body may align to provide inlet air to the capsule cavity 28. The one or more air inlets 28, 38 may extend through a side wall forming the capsule cavity 26. The air inlets 28, 38 may align with or be in air communication with the air inlets 117 of the receptacle article 100. The receptacle cavity 26 is configured to mate with the receptacle article 100. The detachable distal portion 30 may be removed from the mouthpiece portion 20 to expose the receptacle cavity 26 to replace the modular and used or depleted receptacle article 100 with an un-used or full receptacle article 100.
- 16 -FIG. 5 and FIG. 6 illustrative a nicotine powder delivery consumable 100 or receptacle article. The nicotine powder delivery consumable or receptacle article 100 includes a receptacle 110 having a body or sidewall 112 extending from a receptacle first end 111 to an opposing receptacle second end 113 and defining a cavity 116. A capsule 120 is disposed within the cavity 116. The capsule 120 contains particles comprising nicotine. FIG. 6 illustrates the capsule 120 exploded away from the receptacle 110. The nicotine powder delivery consumable or receptacle article 100 may be formed by inserting the capsule 120 into the receptacle 110 and applying the membrane 115 on the receptacle first end 111 to seal the receptacle first end 111 and retain the capsule 120 within the receptacle 110.
The receptacle 110 includes a lateral wall fixed to or integral with the receptacle body or sidewall 112 and an air outlet extending through the lateral wall and into the cavity 116. A
membrane 115 seals the receptacle first end 111. An air inlet 117 extends through the sidewall or body 112 and into the cavity 116. The air inlet 117 is proximate the receptacle first end 111 or closer to the receptacle first end 111 than the receptacle second end 113. The cavity 116 has a length value and a diameter value. The air inlet 117 is proximate the receptacle proximal end 111 a distance. The air inlet 117 may mate with, ore register with, or align with the one or more air inlets 28, 38 on the inhaler body.
The nicotine powder delivery consumable or receptacle article 100 may be a modular or a replaceable component of a multi-use inhaler 10.
The receptacle 110 includes a lateral wall fixed to or integral with the receptacle body or sidewall 112 and an air outlet extending through the lateral wall and into the cavity 116. A
membrane 115 seals the receptacle first end 111. An air inlet 117 extends through the sidewall or body 112 and into the cavity 116. The air inlet 117 is proximate the receptacle first end 111 or closer to the receptacle first end 111 than the receptacle second end 113. The cavity 116 has a length value and a diameter value. The air inlet 117 is proximate the receptacle proximal end 111 a distance. The air inlet 117 may mate with, ore register with, or align with the one or more air inlets 28, 38 on the inhaler body.
The nicotine powder delivery consumable or receptacle article 100 may be a modular or a replaceable component of a multi-use inhaler 10.
Claims (15)
1. An inhaler system suitable for providing nicotine particles, comprising:
an inhaler body extending from a mouthpiece end to a distal end, the inhaler body comprising a mouthpiece portion removably coupled to a distal end portion, the mouthpiece portion extending between the mouthpiece end and a first mating end, the distal end portion extending between a second mating end and the distal end, the mouthpiece portion comprising:
a capsule cavity defined within the first mating end;
a mouthpiece air channel extending from the mouthpiece end to the capsule cavity;
the distal end portion comprising:
a piercing element coupled to the distal end portion, the piercing element being configured to move between a relaxed position and a piercing position, the piercing element extending through the resealable membrane and into the capsule cavity in the piercing position;
a resealable membrane sealing the capsule cavity at the first mating end;
wherein the resealable membrane is configured to reseal when the piercing element moves from the piercing position to the relaxed position where the piercing element is spaced apart from the resealable membrane.
an inhaler body extending from a mouthpiece end to a distal end, the inhaler body comprising a mouthpiece portion removably coupled to a distal end portion, the mouthpiece portion extending between the mouthpiece end and a first mating end, the distal end portion extending between a second mating end and the distal end, the mouthpiece portion comprising:
a capsule cavity defined within the first mating end;
a mouthpiece air channel extending from the mouthpiece end to the capsule cavity;
the distal end portion comprising:
a piercing element coupled to the distal end portion, the piercing element being configured to move between a relaxed position and a piercing position, the piercing element extending through the resealable membrane and into the capsule cavity in the piercing position;
a resealable membrane sealing the capsule cavity at the first mating end;
wherein the resealable membrane is configured to reseal when the piercing element moves from the piercing position to the relaxed position where the piercing element is spaced apart from the resealable membrane.
2. The inhaler system according to claim 1, further comprising a receptacle disposed within the capsule cavity, the receptacle being a replaceable article of the inhaler.
3. The inhaler system according to claim 2, wherein the receptacle contains a capsule, the receptacle is sealed with a membrane at a receptacle first end and defines an air outlet at an opposing receptacle second end, the receptacle includes an air inlet.
4. The inhaler system according to any one of claims 2 or 3, wherein the resealable membrane contacts the receptacle.
5. The inhaler system according to claim 4, wherein the resealable membrane contacts the receptacle membrane.
6. The inhaler system according to any one of claims 3 to 5, wherein the capsule contains solid particles comprising nicotine.
7. The inhaler system according to any one of claims 3 to 6, wherein the inhaler body comprises an air inlet that is in fluid connection with the receptacle air inlet.
8. The inhaler system according to any one of claims 3 to 7, wherein the receptacle air outlet is in fluid connection with the mouthpiece air channel.
9. The inhaler system according to any one of the preceding claims, wherein the resealable membrane is fixed to the second mating end of the distal end portion.
10. The inhaler system according to any one of the preceding claims, wherein the resealable membrane is a septum element.
11. A method, comprising:
placing a receptacle containing a capsule, comprising solid particles comprising nicotine, in the capsule cavity of the inhaler system according to any of the preceding claims;
coupling the mouthpiece portion to the distal end portion, moving the piercing element to pierce the resealable membrane and the capsule;
moving the piercing element to the relaxed position and out of the resealable membrane;
flowing air through the inhaler body to remove the solid particles comprising nicotine and forming a depleted capsule, wherein air does not flow through the resealable membrane.
placing a receptacle containing a capsule, comprising solid particles comprising nicotine, in the capsule cavity of the inhaler system according to any of the preceding claims;
coupling the mouthpiece portion to the distal end portion, moving the piercing element to pierce the resealable membrane and the capsule;
moving the piercing element to the relaxed position and out of the resealable membrane;
flowing air through the inhaler body to remove the solid particles comprising nicotine and forming a depleted capsule, wherein air does not flow through the resealable membrane.
12. The method according to claim 11, further comprising:
uncoupling the mouthpiece portion from the distal end portion to expose the receptacle containing the depleted capsule;
removing the receptacle containing the depleted capsule from the capsule cavity of the inhaler system.
uncoupling the mouthpiece portion from the distal end portion to expose the receptacle containing the depleted capsule;
removing the receptacle containing the depleted capsule from the capsule cavity of the inhaler system.
13. The method according to claim 12, further comprising:
placing a new receptacle containing a capsule, comprising solid particles comprising nicotine, in the capsule cavity of the inhaler system; and coupling the mouthpiece portion to the distal end portion.
placing a new receptacle containing a capsule, comprising solid particles comprising nicotine, in the capsule cavity of the inhaler system; and coupling the mouthpiece portion to the distal end portion.
14. The method according to any one of claims 11 to 13, wherein the placing steps comprise coupling the receptacle air outlet with the mouthpiece air channel.
15. The method according to any one of claims 11 to 14, wherein the flowing air step rotates the capsule about its longitudinal axis.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16178327 | 2016-07-07 | ||
EP16178327.9 | 2016-07-07 | ||
PCT/IB2017/053545 WO2018007886A1 (en) | 2016-07-07 | 2017-06-14 | Nicotine inhaler system |
Publications (1)
Publication Number | Publication Date |
---|---|
CA3022449A1 true CA3022449A1 (en) | 2018-01-11 |
Family
ID=56368901
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA3022449A Abandoned CA3022449A1 (en) | 2016-07-07 | 2017-06-14 | Nicotine inhaler system |
Country Status (16)
Country | Link |
---|---|
US (1) | US11273268B2 (en) |
EP (1) | EP3481471B1 (en) |
JP (1) | JP6976970B2 (en) |
KR (1) | KR102525773B1 (en) |
CN (1) | CN109328083B (en) |
AU (1) | AU2017292138A1 (en) |
BR (1) | BR112018074957A2 (en) |
CA (1) | CA3022449A1 (en) |
IL (1) | IL263339A (en) |
MX (1) | MX2018015619A (en) |
PH (1) | PH12018502713A1 (en) |
PL (1) | PL3481471T3 (en) |
RU (1) | RU2734847C2 (en) |
SG (1) | SG11201811250TA (en) |
WO (1) | WO2018007886A1 (en) |
ZA (1) | ZA201806765B (en) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR3072313B1 (en) * | 2017-10-12 | 2019-10-11 | Aptar France Sas | DEVICE FOR DISPENSING FLUID PRODUCT |
US20200275710A1 (en) * | 2017-10-25 | 2020-09-03 | Philip Morris Products S.A. | Inhaler with boundary element |
EP3755167B1 (en) * | 2018-02-19 | 2022-10-19 | Philip Morris Products S.A. | Dry powder inhaler |
BR112020016652A2 (en) | 2018-03-26 | 2020-12-15 | Philip Morris Products S.A. | INHALER WITH VORTEX CAPSULE CAVITY |
FR3093002B1 (en) * | 2019-02-22 | 2021-02-26 | Aptar France Sas | Fluid dispenser device |
JP2022521894A (en) * | 2019-03-05 | 2022-04-13 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | Holder for inhaler articles |
WO2020178715A1 (en) * | 2019-03-05 | 2020-09-10 | Philip Morris Products S.A. | Piercing device for inhaler article |
EP4033926B1 (en) * | 2019-09-26 | 2023-06-28 | Philip Morris Products S.A. | Inhaler article with a twisted distal end element |
PL4048355T3 (en) * | 2019-10-25 | 2024-02-19 | Philip Morris Products S.A. | Holder for inhaler article |
CN114616010A (en) * | 2019-10-25 | 2022-06-10 | 菲利普莫里斯生产公司 | Inhaler article with open distal end and inhaler system |
JP7480287B2 (en) * | 2019-10-25 | 2024-05-09 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | Inhaler article having a folded distal end |
CN110584222A (en) * | 2019-10-31 | 2019-12-20 | 雷苗苗 | Cigarette bullet and smoking set |
JP2023501143A (en) * | 2019-11-08 | 2023-01-18 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | Prevention of double activation |
TW202145913A (en) | 2020-04-22 | 2021-12-16 | 日商日本煙草產業股份有限公司 | Non-combustion heating-type cigarette and heating-type cigarette product |
EP4140326A4 (en) * | 2020-04-22 | 2024-05-29 | Japan Tobacco Inc | Non-combustion-heated tobacco product and electrically heated tobacco product |
IL303416A (en) * | 2020-12-11 | 2023-08-01 | Philip Morris Products Sa | Inhaler article holder with electrostatic discharge |
IL303415A (en) * | 2020-12-11 | 2023-08-01 | Philip Morris Products Sa | Inhaler system with single plane piercing element |
EP4259249A1 (en) * | 2020-12-11 | 2023-10-18 | Philip Morris Products S.A. | Method of assembly of inhaler article holder |
JP6983449B1 (en) * | 2021-07-09 | 2021-12-17 | 株式会社Green Rush By Weed | Cartridge for heated simulated smoking equipment |
WO2024053914A1 (en) * | 2022-09-06 | 2024-03-14 | Kt & G Corporation | Inhaler |
Family Cites Families (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1687323A (en) * | 1921-07-01 | 1928-10-09 | Cook Lab Inc | Medicament cartridge and hypodermic syringe embodying the same |
US1789921A (en) * | 1925-03-16 | 1931-01-20 | Carl F Adam | Inhaler |
US2503732A (en) * | 1949-01-28 | 1950-04-11 | Wyeth Corp | Inhalator |
US2830597A (en) * | 1953-05-21 | 1958-04-15 | Kummli Jakob | Smoking device |
US2860638A (en) * | 1956-02-21 | 1958-11-18 | Bartolomeo Frank | Smoking device |
US2911123A (en) * | 1956-07-23 | 1959-11-03 | Saccomanno Geno | Bottle cap |
US3030955A (en) * | 1956-10-08 | 1962-04-24 | Baxter Don Inc | Plastic container |
US3012694A (en) * | 1958-10-22 | 1961-12-12 | Johnston William Derrick | Gas dispensing device |
US3365102A (en) * | 1965-12-10 | 1968-01-23 | Willene M. Castleberry | Means for holding, supporting and dispensing liquid comestibles |
FR2224175B1 (en) * | 1973-04-04 | 1978-04-14 | Isf Spa | |
IT982765B (en) | 1973-04-13 | 1974-10-21 | Farmaceutici Italia | INHALER DEVICE |
US4069819A (en) * | 1973-04-13 | 1978-01-24 | Societa Farmaceutici S.P.A. | Inhalation device |
US4111326A (en) * | 1976-03-04 | 1978-09-05 | Becton, Dickinson And Company | Closure for air evacuated container |
IT1116047B (en) | 1979-04-27 | 1986-02-10 | Sigma Tau Ind Farmaceuti | DEVICE FOR THE QUICK INHALATION OF POWDER DRUGS BY PERSONS SUFFERING FROM ASTHMA |
US4511353A (en) * | 1981-07-13 | 1985-04-16 | Alza Corporation | Intravenous system for delivering a beneficial agent |
US4695274A (en) * | 1986-01-31 | 1987-09-22 | Fox Richard L | Protected hypodermic needle |
US4790305A (en) * | 1986-06-23 | 1988-12-13 | The Johns Hopkins University | Medication delivery system |
US4735217A (en) | 1986-08-21 | 1988-04-05 | The Procter & Gamble Company | Dosing device to provide vaporized medicament to the lungs as a fine aerosol |
NO168921C (en) | 1989-07-31 | 1992-04-22 | Svein Knudsen | SMOKE-FREE Cigarette replacement for use in smoking cessation OR FOR USE IN SMOKE-FREE ENVIRONMENTS |
US5122123A (en) * | 1991-01-30 | 1992-06-16 | Vaillancourt Vincent L | Closed system connector assembly |
US5135753A (en) * | 1991-03-12 | 1992-08-04 | Pharmetrix Corporation | Method and therapeutic system for smoking cessation |
US5279607A (en) * | 1991-05-30 | 1994-01-18 | The State University Of New York | Telemetry capsule and process |
DE4128295A1 (en) * | 1991-08-27 | 1993-03-04 | Pfeiffer Erich Gmbh & Co Kg | DISCHARGE DEVICE FOR FLOWABLE MEDIA |
US5441060A (en) * | 1993-02-08 | 1995-08-15 | Duke University | Dry powder delivery system |
US5362496A (en) * | 1993-08-04 | 1994-11-08 | Pharmetrix Corporation | Method and therapeutic system for smoking cessation |
US6102036A (en) * | 1994-04-12 | 2000-08-15 | Smoke-Stop | Breath activated inhaler |
US6209538B1 (en) | 1995-08-02 | 2001-04-03 | Robert A. Casper | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament |
JPH09253208A (en) * | 1996-03-21 | 1997-09-30 | Unisia Jecs Corp | Medicator for nasal cavity |
GB9626233D0 (en) * | 1996-12-18 | 1997-02-05 | Chawla Brinda P S | Medicament packaging and deliveery device |
GB0015043D0 (en) * | 2000-06-21 | 2000-08-09 | Glaxo Group Ltd | Medicament dispenser |
US20020134373A1 (en) * | 2001-03-20 | 2002-09-26 | Igor Gonda | Aerosol generation using sterile multiple dose containers |
US6766799B2 (en) * | 2001-04-16 | 2004-07-27 | Advanced Inhalation Research, Inc. | Inhalation device |
US7931022B2 (en) * | 2001-10-19 | 2011-04-26 | Respirks, Inc. | Method and apparatus for dispensing inhalator medicament |
US6769436B2 (en) * | 2002-06-28 | 2004-08-03 | Richard C. Horian | Volatile inhaler and method |
US7669596B2 (en) * | 2002-12-31 | 2010-03-02 | Novartis Pharma Ag | Aerosolization apparatus with rotating capsule |
US20050056280A1 (en) * | 2002-12-31 | 2005-03-17 | Nektar Therapeutics | Receptacle for an aerosolizable pharmaceutical formulation |
PL1615689T3 (en) * | 2003-04-09 | 2016-06-30 | Novartis Ag | Aerosolization apparatus with capsule puncture alignment guide |
US20060147389A1 (en) * | 2004-04-14 | 2006-07-06 | Vectura Ltd. | Devices and pharmaceutical compositions for enhancing dosing efficiency |
US7861712B2 (en) * | 2004-04-23 | 2011-01-04 | Manta Product Development | Sealed capsule including an integrated puncturing mechanism |
US8123036B2 (en) * | 2004-10-01 | 2012-02-28 | Edge Medical Properties, Llc | Pill assembly for pill packaging and delivery systems |
GB0426780D0 (en) * | 2004-12-07 | 2005-01-12 | 3M Innovative Properties Co | Pressurized inhalation devices |
JP2008535530A (en) | 2005-02-02 | 2008-09-04 | オグレズビー アンド バトラー リサーチ アンド ディヴェロップメント リミテッド | Equipment for evaporating evaporable substances |
GB0503738D0 (en) * | 2005-02-23 | 2005-03-30 | Optinose As | Powder delivery devices |
US20090032427A1 (en) * | 2005-09-29 | 2009-02-05 | Nektar Therapeutics | Receptacles and Kits, Such as for Dry Powder Packaging |
US20070131576A1 (en) * | 2005-11-07 | 2007-06-14 | Advanced Inhalation Research, Inc. | Receptacle packaging with inhaler-accommodating geometry |
US7832399B2 (en) * | 2006-03-10 | 2010-11-16 | One Dose, Llc | Medication inhaler |
US8360057B2 (en) * | 2006-03-10 | 2013-01-29 | Dose One, Llc | Medication inhaler for dispensing multiple capsules |
DE102006016904A1 (en) * | 2006-04-11 | 2007-10-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | inhaler |
GB0623732D0 (en) * | 2006-11-28 | 2007-01-10 | Optinose As | Powder delivery devices |
GB2461008B (en) | 2006-12-08 | 2011-08-10 | Exchange Supplies Ltd | Nicotine inhalation device |
US10668058B2 (en) | 2007-03-30 | 2020-06-02 | Philip Morris Products S.A. | Device and method for delivery of a medicament |
US20080286341A1 (en) * | 2007-05-16 | 2008-11-20 | Sven-Borje Andersson | Buffered coated nicotine containing products |
US8496002B2 (en) * | 2007-06-12 | 2013-07-30 | Civitas Therapeutics, Inc. | Powder inhaler devices |
KR20100047866A (en) * | 2007-07-11 | 2010-05-10 | 애로반스, 인코포레이티드 | Pharmaceutical polypeptide dry powder aerosol formulation and method of preparation |
DE102007036411A1 (en) * | 2007-07-20 | 2009-02-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | powder inhaler |
KR101529354B1 (en) | 2007-12-05 | 2015-06-16 | 노파르티스 아게 | Receptacle for an aerosolizable pharmaceutical formulation |
EP2186537A1 (en) | 2008-11-07 | 2010-05-19 | Inhaleness B.V. | Inhaler, comprising a hydrogen generator |
UA97784C2 (en) | 2009-02-23 | 2012-03-12 | Джапан Тобакко Инк. | Non-heating type tobacco flavor inhaler |
US9861772B2 (en) * | 2010-05-15 | 2018-01-09 | Rai Strategic Holdings, Inc. | Personal vaporizing inhaler cartridge |
US8561609B2 (en) * | 2010-12-07 | 2013-10-22 | Respira Therapeutics, Inc. | Dry powder inhaler |
BR112013022757A2 (en) | 2011-03-09 | 2021-01-05 | Chong Corporation | DRUG DELIVERY SYSTEM |
EP2714162B1 (en) | 2011-05-27 | 2020-01-01 | Boehringer Ingelheim International GmbH | Inhaler and capsule for an inhaler |
PT2797450T (en) * | 2011-12-30 | 2018-02-21 | Philip Morris Products Sa | Smoking article with front-plug and method |
RU2597531C2 (en) | 2012-04-26 | 2016-09-10 | Фонтем Холдингз 1 Б.В. | Electronic cigarette with sealed cartridge |
US20140088044A1 (en) | 2012-09-21 | 2014-03-27 | Basil Rigas | Product comprising a nicotine-containing material and an anti-cancer agent |
PL2925395T3 (en) * | 2012-11-28 | 2019-08-30 | Fontem Holdings 1 B.V. | Device for generating a condensation aerosol from a liquid formulation |
WO2014150826A1 (en) | 2013-03-15 | 2014-09-25 | Aerodesigns, Inc. | Aerosol dispenser with edible cartridge |
DK177788B1 (en) * | 2013-07-12 | 2014-07-07 | Liita Holdings Ltd | Inhaler |
WO2015134307A1 (en) * | 2014-03-04 | 2015-09-11 | Merck Sharp & Dohme Corp. | Prefilled disposable injection device |
US10912334B2 (en) * | 2014-04-28 | 2021-02-09 | Philip Morris Products S.A. | Flavoured nicotine powder inhaler |
UA122124C2 (en) * | 2014-06-20 | 2020-09-25 | Філіп Морріс Продактс С.А. | Nicotine powder delivery system with airflow management means |
CN204362977U (en) * | 2015-01-26 | 2015-06-03 | 梅小建 | A kind of encapsulating structure of electronic cigarette tobacco tar |
WO2017207586A1 (en) * | 2016-05-31 | 2017-12-07 | Philip Morris Products S.A. | Aerosol-generating system comprising a heated aerosol-generating article |
-
2017
- 2017-06-14 MX MX2018015619A patent/MX2018015619A/en unknown
- 2017-06-14 US US16/309,739 patent/US11273268B2/en active Active
- 2017-06-14 BR BR112018074957-5A patent/BR112018074957A2/en not_active IP Right Cessation
- 2017-06-14 EP EP17732584.2A patent/EP3481471B1/en active Active
- 2017-06-14 CN CN201780038637.1A patent/CN109328083B/en active Active
- 2017-06-14 AU AU2017292138A patent/AU2017292138A1/en not_active Abandoned
- 2017-06-14 KR KR1020187034988A patent/KR102525773B1/en active IP Right Grant
- 2017-06-14 WO PCT/IB2017/053545 patent/WO2018007886A1/en active Search and Examination
- 2017-06-14 RU RU2018144596A patent/RU2734847C2/en active
- 2017-06-14 SG SG11201811250TA patent/SG11201811250TA/en unknown
- 2017-06-14 PL PL17732584T patent/PL3481471T3/en unknown
- 2017-06-14 CA CA3022449A patent/CA3022449A1/en not_active Abandoned
- 2017-06-14 JP JP2018563609A patent/JP6976970B2/en active Active
-
2018
- 2018-10-11 ZA ZA2018/06765A patent/ZA201806765B/en unknown
- 2018-11-28 IL IL263339A patent/IL263339A/en unknown
- 2018-12-21 PH PH12018502713A patent/PH12018502713A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP3481471B1 (en) | 2020-08-26 |
WO2018007886A1 (en) | 2018-01-11 |
AU2017292138A1 (en) | 2018-11-08 |
CN109328083B (en) | 2021-07-02 |
PH12018502713A1 (en) | 2019-07-29 |
CN109328083A (en) | 2019-02-12 |
MX2018015619A (en) | 2019-04-11 |
US11273268B2 (en) | 2022-03-15 |
RU2018144596A (en) | 2020-08-07 |
BR112018074957A2 (en) | 2019-03-12 |
EP3481471A1 (en) | 2019-05-15 |
JP2019524060A (en) | 2019-09-05 |
RU2018144596A3 (en) | 2020-08-07 |
IL263339A (en) | 2018-12-31 |
SG11201811250TA (en) | 2019-01-30 |
JP6976970B2 (en) | 2021-12-08 |
PL3481471T3 (en) | 2021-01-11 |
KR102525773B1 (en) | 2023-04-27 |
RU2734847C2 (en) | 2020-10-23 |
US20190116879A1 (en) | 2019-04-25 |
ZA201806765B (en) | 2019-07-31 |
KR20190026659A (en) | 2019-03-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US11273268B2 (en) | Nicotine inhaler system | |
EP3548125B1 (en) | Inhaler with swirl end plug | |
EP3393565B1 (en) | Nicotine particle capsule | |
EP3481472B1 (en) | Nicotine particle delivery consumable | |
EP3755167B1 (en) | Dry powder inhaler | |
EP3548126B1 (en) | Inhaler with sized cavity | |
EP3700611B1 (en) | Piercing accessory for inhaler article and system | |
EP3700376A1 (en) | Inhaler with boundary element | |
NZ747467A (en) | Nicotine inhaler system | |
NZ747468A (en) | Nicotine particle delivery consumable |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |
Effective date: 20221214 |
|
FZDE | Discontinued |
Effective date: 20221214 |