CA2902186C - Aptamers that bind to il-6 and their use in treating or diagnosing il-6 mediated conditions - Google Patents

Aptamers that bind to il-6 and their use in treating or diagnosing il-6 mediated conditions Download PDF

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Publication number
CA2902186C
CA2902186C CA2902186A CA2902186A CA2902186C CA 2902186 C CA2902186 C CA 2902186C CA 2902186 A CA2902186 A CA 2902186A CA 2902186 A CA2902186 A CA 2902186A CA 2902186 C CA2902186 C CA 2902186C
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Prior art keywords
disease
aptamer
cancer
nap
seq
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CA2902186A
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English (en)
French (fr)
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CA2902186A1 (en
Inventor
Shashi Gupta
Masao HIROTA
Daniel J. Schneider
Tomoki SUZUKI
Thale C. Jarvis
Yuichi Ishikawa
Ikuo MURAKAMI
Amy GELINAS
Sheela Waugh
Nebojsa Janjic
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Otsuka Pharmaceutical Co Ltd
Somalogic Operating Co Inc
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Otsuka Pharmaceutical Co Ltd
Somalogic Operating Co Inc
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/04Centrally acting analgesics, e.g. opioids
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    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
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    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/16Aptamers
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
CA2902186A 2013-03-14 2014-03-12 Aptamers that bind to il-6 and their use in treating or diagnosing il-6 mediated conditions Active CA2902186C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361782938P 2013-03-14 2013-03-14
US61/782,938 2013-03-14
US201361789244P 2013-03-15 2013-03-15
US61/789,244 2013-03-15
PCT/US2014/024669 WO2014159669A2 (en) 2013-03-14 2014-03-12 Aptamers that bind to il-6 and their use in treating or diagnosing il-6 mediated conditions

Publications (2)

Publication Number Publication Date
CA2902186A1 CA2902186A1 (en) 2014-10-02
CA2902186C true CA2902186C (en) 2023-04-11

Family

ID=51625609

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2902186A Active CA2902186C (en) 2013-03-14 2014-03-12 Aptamers that bind to il-6 and their use in treating or diagnosing il-6 mediated conditions

Country Status (11)

Country Link
US (1) US9206429B2 (zh)
EP (1) EP2970979B1 (zh)
JP (1) JP6591392B2 (zh)
KR (1) KR102242874B1 (zh)
CN (3) CN112961860A (zh)
AU (1) AU2014244534B2 (zh)
CA (1) CA2902186C (zh)
ES (1) ES2710723T3 (zh)
HK (1) HK1217512A1 (zh)
SG (1) SG11201507335QA (zh)
WO (1) WO2014159669A2 (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104561013A (zh) * 2015-01-05 2015-04-29 中国人民解放军***福州总医院 基于高通量测序技术进行核酸适配体序列优化的方法
CN105203763B (zh) * 2015-11-15 2017-01-04 北京博奥医学检验所有限公司 一种口腔癌特异性检测的试剂盒
JP7203613B2 (ja) 2016-07-01 2023-01-13 ソマロジック オペレーティング カンパニー インコーポレイテッド 修飾ヌクレオシドを含むオリゴヌクレオチド
CN107663220B (zh) * 2016-07-27 2020-10-02 上海伯豪医学检验所有限公司 修饰碱基、包含修饰碱基的核酸、适配体及其应用
WO2018079864A1 (ko) * 2016-10-24 2018-05-03 김성천 TNF-α 결합 압타머 및 그것의 치료적 용도
CN107238712B (zh) * 2017-06-05 2018-12-28 中国人民解放军***总医院 血浆s100a12在st段抬高型心肌梗死预后中的应用
US11649460B2 (en) 2020-03-20 2023-05-16 Joao Francisco Peinado Pereira DNA aptamers, method for inhibiting human galectin-1 and method of treating a mammal in need thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070166741A1 (en) * 1998-12-14 2007-07-19 Somalogic, Incorporated Multiplexed analyses of test samples
CA2526853A1 (en) 2003-05-23 2005-03-03 Board Of Regents - The University Of Texas System Structure based and combinatorially selected oligonucleoside phosphorothioate and phosphorodithioate aptamer targeting ap-1 transcription factors
AU2005220910A1 (en) 2004-03-05 2005-09-22 Archemix Corp. Aptamers to the human IL-12 cytokine family and their use as autoimmune disease therapeutics
SI1994171T1 (sl) 2006-01-17 2015-07-31 Somalogic, Inc. Multipleksirane analize testnih vzorcev
US8975026B2 (en) * 2007-01-16 2015-03-10 Somalogic, Inc. Method for generating aptamers with improved off-rates
US7964356B2 (en) 2007-01-16 2011-06-21 Somalogic, Inc. Method for generating aptamers with improved off-rates
US7855054B2 (en) 2007-01-16 2010-12-21 Somalogic, Inc. Multiplexed analyses of test samples
US8409795B2 (en) 2007-07-17 2013-04-02 Somalogic, Inc. Selex and photoSELEX
SG184497A1 (en) * 2010-04-12 2012-11-29 Somalogic Inc 5-position modified pyrimidines and their use
US8658613B2 (en) 2010-11-30 2014-02-25 Otc Biotechnologies, Llc Methods and compositions of nucleic acid ligands for detection of clinical analytes related to human health
FR2978964B1 (fr) 2011-08-09 2015-02-20 Conservatoire Nat Arts Composition vaccinale anti-il-6

Also Published As

Publication number Publication date
CA2902186A1 (en) 2014-10-02
HK1217512A1 (zh) 2017-01-13
CN112961860A (zh) 2021-06-15
CN105051193A (zh) 2015-11-11
CN109439664B (zh) 2024-03-08
KR102242874B1 (ko) 2021-04-21
AU2014244534B2 (en) 2020-04-30
US9206429B2 (en) 2015-12-08
SG11201507335QA (en) 2015-10-29
ES2710723T3 (es) 2019-04-26
EP2970979B1 (en) 2018-11-21
EP2970979A4 (en) 2016-11-09
KR20150140669A (ko) 2015-12-16
JP2016517273A (ja) 2016-06-16
US20140315986A1 (en) 2014-10-23
AU2014244534A1 (en) 2015-09-10
CN109439664A (zh) 2019-03-08
JP6591392B2 (ja) 2019-10-16
WO2014159669A3 (en) 2014-12-04
WO2014159669A2 (en) 2014-10-02
EP2970979A2 (en) 2016-01-20

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