CA2860862A1 - Methodes et compositions pour le traitement du cancer et procedes associes - Google Patents
Methodes et compositions pour le traitement du cancer et procedes associes Download PDFInfo
- Publication number
- CA2860862A1 CA2860862A1 CA2860862A CA2860862A CA2860862A1 CA 2860862 A1 CA2860862 A1 CA 2860862A1 CA 2860862 A CA2860862 A CA 2860862A CA 2860862 A CA2860862 A CA 2860862A CA 2860862 A1 CA2860862 A1 CA 2860862A1
- Authority
- CA
- Canada
- Prior art keywords
- egfr
- agent
- klf6
- patient
- foxo1
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57423—Specifically defined cancers of lung
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2011/020864 WO2012096654A1 (fr) | 2011-01-11 | 2011-01-11 | Méthodes et compositions pour le traitement du cancer et procédés associés |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2860862A1 true CA2860862A1 (fr) | 2012-07-19 |
Family
ID=46507358
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2860862A Abandoned CA2860862A1 (fr) | 2011-01-11 | 2011-01-11 | Methodes et compositions pour le traitement du cancer et procedes associes |
Country Status (2)
Country | Link |
---|---|
CA (1) | CA2860862A1 (fr) |
WO (1) | WO2012096654A1 (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9134297B2 (en) * | 2011-01-11 | 2015-09-15 | Icahn School Of Medicine At Mount Sinai | Method and compositions for treating cancer and related methods |
WO2015136061A2 (fr) * | 2014-03-13 | 2015-09-17 | Ecole Polytechnique Federale De Lausanne (Epfl) | Association de médicaments pour le traitement de maladies prolifératives |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA06003066A (es) * | 2003-09-18 | 2006-06-20 | Combinatorx Inc | Combinaciones de farmacos para el tratamiento de neoplasmas. |
WO2007008982A2 (fr) * | 2005-07-11 | 2007-01-18 | Irm Llc | Methodes et composition modulant l'activite du foxo1 et la signalisation par l'insuline |
WO2007106503A2 (fr) * | 2006-03-13 | 2007-09-20 | Osi Pharmaceuticals, Inc. | Traitement combiné avec un inhibiteur de kinase egfr et un agent sensibilisant les cellules tumorales aux effets des inhibiteurs de kinase egfr |
-
2011
- 2011-01-11 WO PCT/US2011/020864 patent/WO2012096654A1/fr active Application Filing
- 2011-01-11 CA CA2860862A patent/CA2860862A1/fr not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2012096654A1 (fr) | 2012-07-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Blakely et al. | NF-κB-activating complex engaged in response to EGFR oncogene inhibition drives tumor cell survival and residual disease in lung cancer | |
Dong et al. | Selective inhibition of PDGFR by imatinib elicits the sustained activation of ERK and downstream receptor signaling in malignant glioma cells | |
KR102473113B1 (ko) | 암 치료를 위한 병용 요법 | |
Said et al. | Tumor endothelin-1 enhances metastatic colonization of the lung in mouse xenograft models of bladder cancer | |
Santi et al. | Ablation of Akt2 induces autophagy through cell cycle arrest, the downregulation of p70S6K, and the deregulation of mitochondria in MDA-MB231 cells | |
Felip et al. | Therapeutic potential of the new TRIB3-mediated cell autophagy anticancer drug ABTL0812 in endometrial cancer | |
US20210008073A1 (en) | Platelet-derived growth factor receptor mutations and compositions and methods relating thereto | |
US9494572B2 (en) | Method and compositions for treating cancer and related methods | |
Raab et al. | Blocking mitotic exit of ovarian cancer cells by pharmaceutical inhibition of the anaphase-promoting complex reduces chromosomal instability | |
EP2994155B1 (fr) | Ciblage de l'interaction entre un egfr et un sglt1 pour la cancérothérapie | |
Yan et al. | Elucidating the role of the FoxO3a transcription factor in the IGF-1-induced migration and invasion of uveal melanoma cancer cells | |
Cuneo et al. | Enhancing the radiation response in KRAS mutant colorectal cancers using the c-Met inhibitor crizotinib | |
US8198266B2 (en) | Use of an EGFR antagonist for the treatment of glomerolonephritis | |
US11221334B2 (en) | Method for determining breast cancer treatment | |
Chung et al. | Sorafenib suppresses TGF-β responses by inducing caveolae/lipid raft-mediated internalization/degradation of cell-surface type II TGF-β receptors: Implications in development of effective adjunctive therapy for hepatocellular carcinoma | |
Parag-Sharma et al. | Synergistic efficacy of combined EGFR and HDAC inhibitors overcomes tolerance to EGFR monotherapy in salivary mucoepidermoid carcinoma | |
Moreira et al. | Targeting MYC-driven replication stress in medulloblastoma with AZD1775 and gemcitabine | |
US20130344140A1 (en) | Novel pharmaceutical combinations and methods for treating cancer | |
WO2012097054A1 (fr) | Méthodes et compositions pour le traitement du cancer et méthodes associées | |
CA2860862A1 (fr) | Methodes et compositions pour le traitement du cancer et procedes associes | |
Shaw et al. | AKT mediates the pro-survival effects of KIT in ovarian cancer cells and is a determinant of sensitivity to imatinib mesylate | |
US20180133214A1 (en) | Pharmaceutical composition for treating cancer and a method of using the same | |
US8431587B2 (en) | Method for the treatment of cancer | |
EP2905032B1 (fr) | Procédé et composition pharmaceutique pour inhiber la voie de signalisation pi3k/akt/mtor | |
US20100152140A1 (en) | Method of Cancer Treatment with Naphthol Analogs |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request |
Effective date: 20160108 |
|
FZDE | Dead |
Effective date: 20180530 |