CA2666130A1 - Kinase inhibitors - Google Patents

Kinase inhibitors Download PDF

Info

Publication number
CA2666130A1
CA2666130A1 CA002666130A CA2666130A CA2666130A1 CA 2666130 A1 CA2666130 A1 CA 2666130A1 CA 002666130 A CA002666130 A CA 002666130A CA 2666130 A CA2666130 A CA 2666130A CA 2666130 A1 CA2666130 A1 CA 2666130A1
Authority
CA
Canada
Prior art keywords
alkyl
pyrido
phenyl
hetero
indole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002666130A
Other languages
English (en)
French (fr)
Inventor
Jason W. Brown
Qing Dong
Bheema R. Paraselli
Jeffrey Alan Stafford
Michael B. Wallace
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda San Diego, Inc.
Jason W. Brown
Qing Dong
Bheema R. Paraselli
Jeffrey Alan Stafford
Michael B. Wallace
Takeda Pharmaceutical Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/539,857 external-priority patent/US8119655B2/en
Application filed by Takeda San Diego, Inc., Jason W. Brown, Qing Dong, Bheema R. Paraselli, Jeffrey Alan Stafford, Michael B. Wallace, Takeda Pharmaceutical Company Limited filed Critical Takeda San Diego, Inc.
Publication of CA2666130A1 publication Critical patent/CA2666130A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002666130A 2006-10-09 2007-10-08 Kinase inhibitors Abandoned CA2666130A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US11/539,857 US8119655B2 (en) 2005-10-07 2006-10-09 Kinase inhibitors
US11/539,857 2006-10-09
PCT/US2006/039667 WO2007044779A1 (en) 2005-10-07 2006-10-10 Kinase inhibitors
USPCT/US2006/39667 2006-10-10
US91262507P 2007-04-18 2007-04-18
US60/912,625 2007-04-18
PCT/US2007/080710 WO2008045834A2 (en) 2006-10-09 2007-10-08 Kinase inhibitors

Publications (1)

Publication Number Publication Date
CA2666130A1 true CA2666130A1 (en) 2008-04-17

Family

ID=40800472

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002666130A Abandoned CA2666130A1 (en) 2006-10-09 2007-10-08 Kinase inhibitors

Country Status (3)

Country Link
EP (1) EP2081930A2 (de)
CA (1) CA2666130A1 (de)
WO (1) WO2008045834A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
EP2297145A2 (de) * 2008-04-16 2011-03-23 Takeda Pharmaceutical Company Limited Polymorphe von 5-(3-(ethylsulfonyl)phenyl)-3,8-dimethyl-n-(1-methylpiperidin-4-yl)-9h-pyrido[2,3-b]indol-7-carbonsäureamid und verfahren zu deren anwendung
WO2009129401A1 (en) * 2008-04-16 2009-10-22 Takeda Pharmaceutical Company Limited Kinase inhibitors
WO2009129191A1 (en) * 2008-04-16 2009-10-22 Takeda Pharmaceutical Company Limited Polymorphs of hydrochloride salt o5-(3-(ethylsulfonyl)phenyl)-3,8-dimethyl-n-(1-methylpiperidin-4-yl)-9h-pyrido[2,3-b] indole-7-carboxamideand methods of use therefor
US8501765B2 (en) 2008-06-11 2013-08-06 Genentech, Inc. Diazacarbazoles and methods of use
FR2950891B1 (fr) * 2009-10-06 2012-11-09 Sanofi Aventis Derives d'azacarbolines 9h-pyrrolo[2,3-b:5,4-c']dipyridine, leur preparation et leur utilisation therapeutique
US20110183938A1 (en) 2009-12-16 2011-07-28 Genentech, Inc. 1,7-diazacarbazoles and methods of use
CN115353484A (zh) * 2022-07-05 2022-11-18 西北师范大学 一种4位氨基取代咔唑、二苯并[b，d]呋喃和芴衍生物的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1209158A1 (de) * 2000-11-18 2002-05-29 Aventis Pharma Deutschland GmbH Substitutierte beta-Carboline
EP1134221A1 (de) * 2000-03-15 2001-09-19 Aventis Pharma Deutschland GmbH Substituierte beta-Carboline als lkB-Kinasehemmer
MXPA04011930A (es) * 2002-05-31 2005-03-31 Yamanouchi Pharma Co Ltd Derivados de tetrahidropirano.
EP1773807A2 (de) * 2004-06-14 2007-04-18 Takeda San Diego, Inc. Kinase-inhibitoren
FR2876377B1 (fr) * 2004-10-11 2007-03-16 Univ Claude Bernard Lyon Nouveaux derives de 9h-pyrido[2,3-b]indole, leur procede de preparation, ainsi que les compositions pharmaceutiques contenant de tels composes
WO2006131552A1 (de) * 2005-06-09 2006-12-14 Boehringer Ingelheim International Gmbh Alpha-carboline als cdk-1 inhibitoren

Also Published As

Publication number Publication date
WO2008045834A2 (en) 2008-04-17
WO2008045834A3 (en) 2008-07-24
EP2081930A2 (de) 2009-07-29

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead

Effective date: 20131202