CA2645652A1 - Composes de bicycloheteroaryle en tant que modulateurs de p2x7 modulators et leurs utilisations - Google Patents

Composes de bicycloheteroaryle en tant que modulateurs de p2x7 modulators et leurs utilisations Download PDF

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Publication number
CA2645652A1
CA2645652A1 CA002645652A CA2645652A CA2645652A1 CA 2645652 A1 CA2645652 A1 CA 2645652A1 CA 002645652 A CA002645652 A CA 002645652A CA 2645652 A CA2645652 A CA 2645652A CA 2645652 A1 CA2645652 A1 CA 2645652A1
Authority
CA
Canada
Prior art keywords
substituted
unsubstituted
compound according
alkyl
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002645652A
Other languages
English (en)
Inventor
Michael G. Kelly
John Kincaid
Yunfeng Fang
Yeyu Cao
Carl Kaub
Sumithra Gowlugari
Zhan Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Renovis Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2645652A1 publication Critical patent/CA2645652A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002645652A 2006-03-16 2007-03-16 Composes de bicycloheteroaryle en tant que modulateurs de p2x7 modulators et leurs utilisations Abandoned CA2645652A1 (fr)

Applications Claiming Priority (27)

Application Number Priority Date Filing Date Title
US78278206P 2006-03-16 2006-03-16
US78330406P 2006-03-16 2006-03-16
US78277506P 2006-03-16 2006-03-16
US78374806P 2006-03-16 2006-03-16
US78312106P 2006-03-16 2006-03-16
US78297306P 2006-03-16 2006-03-16
US78277606P 2006-03-16 2006-03-16
US78292206P 2006-03-16 2006-03-16
US78359006P 2006-03-16 2006-03-16
US60/783,304 2006-03-16
US60/782,782 2006-03-16
US60/782,923 2006-03-16
US60/782,922 2006-03-16
US60/783,748 2006-03-16
US60/783,590 2006-03-16
US60/782,775 2006-03-16
US60/782,776 2006-03-16
US60/783,121 2006-03-16
US60/782,973 2006-03-16
US83141606P 2006-07-17 2006-07-17
US60/831,416 2006-07-17
US84699306P 2006-09-25 2006-09-25
US60/846,993 2006-09-25
US91812307P 2007-03-15 2007-03-15
US60/918,123 2007-03-15
US78292307P 2007-03-16 2007-03-16
PCT/US2007/006676 WO2007109154A2 (fr) 2006-03-16 2007-03-16 Composés de bicyclohétéroaryle en tant que modulateurs de p2x7 modulators et leurs utilisations

Publications (1)

Publication Number Publication Date
CA2645652A1 true CA2645652A1 (fr) 2007-09-27

Family

ID=38522986

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002645652A Abandoned CA2645652A1 (fr) 2006-03-16 2007-03-16 Composes de bicycloheteroaryle en tant que modulateurs de p2x7 modulators et leurs utilisations

Country Status (2)

Country Link
CA (1) CA2645652A1 (fr)
WO (1) WO2007109154A2 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010520875A (ja) * 2007-03-09 2010-06-17 レノビス， インコーポレイテッド Ｐ２ｘ７調節因子としてのビシクロヘテロアリール化合物およびその使用
AU2008319735A1 (en) * 2007-10-31 2009-05-07 Nissan Chemical Industries, Ltd. Pyridazinone derivatives and use thereof as P2X7 receptor inhibitors
EA022505B1 (ru) 2008-03-25 2016-01-29 Эффектис Фармасьютиклз Аг Новые p2x7r антагонисты и их применение
CN102317284A (zh) * 2008-12-16 2012-01-11 西特里斯药业公司 作为沉默调节蛋白调节剂的酞嗪酮和相关的类似物
GB0906274D0 (en) 2009-04-09 2009-05-20 Ge Healthcare Ltd Imaging the central nervous system
WO2010118921A1 (fr) 2009-04-14 2010-10-21 Affectis Pharmaceuticals Ag Nouveaux antagonistes de p2x7r et leur utilisation
EP2569281A1 (fr) 2010-05-14 2013-03-20 Affectis Pharmaceuticals AG Nouveaux procédés de préparation d'antagonistes du p2x7r
WO2012110190A1 (fr) 2011-02-17 2012-08-23 Affectis Pharmaceuticals Ag Nouveaux antagonistes p2x7r et leur utilisation
WO2012163456A1 (fr) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Nouveaux antagonistes de p2x7r et leur utilisation
WO2012163792A1 (fr) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Nouveaux antagonistes de p2x7r et leur utilisation
CN103687860B (zh) 2011-07-22 2016-06-08 埃科特莱茵药品有限公司 作为p2x7受体拮抗剂的杂环酰胺衍生物
CN104066737B (zh) 2012-01-20 2016-06-08 埃科特莱茵药品有限公司 作为p2x7受体拮抗剂的杂环酰胺衍生物
MA38192B1 (fr) 2012-12-12 2017-11-30 Actelion Pharmaceuticals Ltd Dérivés d'indole carboxamide utilisés en tant qu'antagonistes du récepteur p2x7
CN104854087B (zh) 2012-12-18 2017-03-22 埃科特莱茵药品有限公司 作为p2x7受体拮抗剂的吲哚羧酰胺衍生物
WO2014115072A1 (fr) 2013-01-22 2014-07-31 Actelion Pharmaceuticals Ltd Dérivés d'amides hétérocycliques utilisés comme antagonistes du récepteur p2x7
EP2956457B1 (fr) 2013-01-22 2016-11-23 Actelion Pharmaceuticals Ltd Dérivés d'amides hétérocycliques utilisés comme antagonistes du récepteur p2x7
WO2015144001A1 (fr) 2014-03-24 2015-10-01 南京明德新药研发股份有限公司 Dérivés de quinoléine comme inhibiteurs de smo
CA2983927A1 (fr) 2015-05-06 2016-11-10 The Regents Of The University Of California Modulateurs de k-ras
CN110785414A (zh) 2017-04-20 2020-02-11 加利福尼亚大学董事会 K-Ras调节剂
TWI825637B (zh) 2021-03-31 2023-12-11 美商輝瑞股份有限公司 啶－１，６（２ｈ，７ｈ）－二酮

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1566099A (zh) * 2003-06-13 2005-01-19 中国科学院上海药物研究所 异喹啉－1,3,4－三酮类化合物、制备方法及其用途

Also Published As

Publication number Publication date
WO2007109154A3 (fr) 2008-05-02
WO2007109154A2 (fr) 2007-09-27

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Legal Events

Date Code Title Description
FZDE Discontinued