CA2629402C - Modulateurs de beta-secretase et procedes d'utilisation associes - Google Patents

Modulateurs de beta-secretase et procedes d'utilisation associes Download PDF

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Publication number
CA2629402C
CA2629402C CA2629402A CA2629402A CA2629402C CA 2629402 C CA2629402 C CA 2629402C CA 2629402 A CA2629402 A CA 2629402A CA 2629402 A CA2629402 A CA 2629402A CA 2629402 C CA2629402 C CA 2629402C
Authority
CA
Canada
Prior art keywords
amino
acetamide
methyl
dihydrospiro
pyridin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2629402A
Other languages
English (en)
Other versions
CA2629402A1 (fr
Inventor
Wenge Zhong
Stephen Hitchcock
Brian K Albrecht
Michael Bartberger
James Brown
Ryan Brown (Deceased)
Stuart C. Chaffee
Yuan Cheng
Michael Croghan
Russell Graceffa
Scott Harried
Dean Hickman
Daniel Horne
Randall Hungate
Ted Judd
Matthew Kaller
Charles Kreiman
Daniel La
Patricia Lopez
Craig E. Masse
Holger Monenschein
Thomas Nguyen
Thomas Nixey
Vinod F. Patel
Lewis Pennington
Matthew Weiss
Qiufen Xue
Bryant Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39708735&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2629402(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CA2629402A1 publication Critical patent/CA2629402A1/fr
Application granted granted Critical
Publication of CA2629402C publication Critical patent/CA2629402C/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CA2629402A 2005-11-21 2006-11-13 Modulateurs de beta-secretase et procedes d'utilisation associes Expired - Fee Related CA2629402C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US73910805P 2005-11-21 2005-11-21
US60/739,108 2005-11-21
US85482406P 2006-10-27 2006-10-27
US60/854,824 2006-10-27
PCT/US2006/044058 WO2007061670A1 (fr) 2005-11-21 2006-11-13 Modulateurs de beta-secretase et procedes d'utilisation associes

Publications (2)

Publication Number Publication Date
CA2629402A1 CA2629402A1 (fr) 2007-05-31
CA2629402C true CA2629402C (fr) 2011-07-26

Family

ID=39708735

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2629402A Expired - Fee Related CA2629402C (fr) 2005-11-21 2006-11-13 Modulateurs de beta-secretase et procedes d'utilisation associes

Country Status (8)

Country Link
EP (1) EP1971598A1 (fr)
JP (1) JP5274258B2 (fr)
AR (1) AR057985A1 (fr)
AU (1) AU2006316620B2 (fr)
CA (1) CA2629402C (fr)
PE (1) PE20070645A1 (fr)
TW (1) TW200800966A (fr)
WO (1) WO2007061670A1 (fr)

Families Citing this family (7)

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US7763609B2 (en) 2003-12-15 2010-07-27 Schering Corporation Heterocyclic aspartyl protease inhibitors
MX2009012608A (es) * 2007-05-25 2009-12-07 Amgen Inc Compuestos de hidroxietil amina substituidos como moduladores de beta-secretasa y metodos de uso.
US8163909B2 (en) * 2007-05-25 2012-04-24 Amgen Inc. Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use
EP2734494B1 (fr) 2011-07-21 2019-01-02 GE Healthcare Limited Composés précurseurs et leurs procédés de fabrication
CA2867851A1 (fr) * 2012-03-20 2013-09-26 Elan Pharmaceuticals, Inc. Dihydro-thiazine spirocycliques et inhibiteurs de bace dihydro-oxazine et compositions et utilisations de ceux-ci
JP6562361B2 (ja) * 2014-07-16 2019-08-21 国立研究開発法人科学技術振興機構 ベンゾチアゾール化合物及びこれを含有する医薬
US20220185815A1 (en) 2019-03-06 2022-06-16 Daiichi Sankyo Company, Limited Pyrrolopyrazole derivative

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MY138097A (en) 2000-03-22 2009-04-30 Du Pont Insecticidal anthranilamides
ATE314343T1 (de) 2000-06-30 2006-01-15 Elan Pharm Inc Verbindungen zur behandlung der alzheimerischen krankheit
US7196163B2 (en) 2001-05-22 2007-03-27 Merk & Co., Inc. Assays using amyloid precursor proteins with modified β-secretase cleavage sites to monitor β-secretase activity
US6982264B2 (en) 2001-06-27 2006-01-03 Elan Pharmaceuticals, Inc. Substituted alcohols useful in treatment of Alzheimer's disease
KR100713137B1 (ko) 2001-06-28 2007-05-02 동화약품공업주식회사 신규의 2,4-디플루오로벤즈아미드 유도체
WO2003006013A1 (fr) 2001-07-10 2003-01-23 Elan Pharmaceuticals, Inc. Diaminediols pour le traitement de la maladie d'alzheimer
WO2003006021A1 (fr) 2001-07-10 2003-01-23 Elan Pharmaceuticals, Inc. Derives de statine alpha-hydroxyamide pour le traitement de la maladie d'alzheimer
PL368052A1 (en) 2001-07-11 2005-03-21 Elan Pharmaceuticals, Inc. N-(3-amino-2-hydroxy-propyl) substituted alkylamide compounds
CA2462851A1 (fr) 2001-10-04 2003-04-10 Elan Pharmaceuticals, Inc. Hydroxypropylamines
BR0213138A (pt) 2001-10-05 2004-08-24 Elan Pharm Inc Métodos de tratar ou prevenir mal de alzheimer e uma doença distinguida por depósito de beta-amilóide no cérebro, de tratar um paciente que tenha, ou de prevenir um paciente de contrair uma doença ou condição, de produzir um complexo de beta-secretase e de inibir a produção de placa beta-amilóide em um animal, composição e uso de um composto
US20050038019A1 (en) 2001-10-29 2005-02-17 Beck James P. Hydroxy substituted amides for the treatment of alzheimer's disease
EA200400648A1 (ru) 2001-11-08 2005-04-28 Элан Фармасьютикалз, Инк. N, n'-замещенные производные 1,3-диамино-2-гидроксипропана
TW200304374A (en) 2001-11-30 2003-10-01 Smithkline Beecham Plc Novel compounds
BR0214736A (pt) 2001-12-06 2004-11-23 Elan Pharm Inc Composto e seus sais farmaceuticamente aceitáveis, composição farmacêutica e método de tratar seres humanos ou animais que sofrem de doenças ou condições
WO2003057721A2 (fr) 2002-01-04 2003-07-17 Elan Pharmaceuticals, Inc. Amino carboxamides substitues destines au traitement de la maladie d'alzheimer
EP1471910A2 (fr) 2002-01-17 2004-11-03 Neurogen Corporation Analogues de quinazoline-4-ylamine substitues comme modulateurs de receptors de la capsaicin
AU2003276047A1 (en) 2002-06-17 2003-12-31 Sunesis Pharmaceuticals, Inc. Aspartyl protease inhibitors
ATE370131T1 (de) 2002-06-20 2007-09-15 Pharmacia & Upjohn Co Llc Verfahren zur herstellung von 5-(1,3-oxazol-2- yl)benzoesäurederivaten
UY27967A1 (es) 2002-09-10 2004-05-31 Pfizer Acetil 2-hindroxi-1,3-diaminoalcanos
US7362070B2 (en) 2002-11-04 2008-04-22 Hamilton Sundstrand Corporation Electric motor control system including position determination and error correction
WO2004043916A1 (fr) 2002-11-12 2004-05-27 Merck & Co., Inc. Inhibiteurs de beta-secretase phenylcarboxamide utilises dans le traitement de la maladie d'alzheimer
AU2003293155A1 (en) * 2002-11-27 2004-06-23 Elan Pharmaceutical, Inc. Substituted ureas and carbamates
GB0228410D0 (en) 2002-12-05 2003-01-08 Glaxo Group Ltd Novel Compounds
US7371853B2 (en) 2003-01-07 2008-05-13 Merck & Co., Inc. Macrocyclic β-secretase inhibitors for the treatment of Alzheimer's disease
JP2006520371A (ja) 2003-03-14 2006-09-07 メルク　シャープ　エンド　ドーム　リミテッド 軽症の認識損傷の治療方法及びアルツハイマー病の予防又は遅延方法
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UY28279A1 (es) * 2003-04-21 2004-11-30 Pharmacia & Amp Fenacilo 2 -hidroxi - 3 - diaminoalcanos
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WO2005004802A2 (fr) 2003-06-30 2005-01-20 Merck & Co., Inc. Inhibiteurs de la beta-secretase a base de n-alkyle phenylcarboxamide pour le traitement de la maladie d'alzheimer
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JP2007528403A (ja) * 2004-03-09 2007-10-11 エラン ファーマシューティカルズ，インコーポレイテッド 二環式アスパラギン酸プロテアーゼ阻害薬を用いるアミロイドーシスの処置方法
EP1751091A2 (fr) * 2004-03-25 2007-02-14 Elan Pharmaceuticals, Inc. 1,3-diaminopropanes a substitution 2-amino- et 2-thio-

Also Published As

Publication number Publication date
JP2009516684A (ja) 2009-04-23
PE20070645A1 (es) 2007-08-24
AU2006316620B2 (en) 2011-03-03
AU2006316620A1 (en) 2007-05-31
CA2629402A1 (fr) 2007-05-31
EP1971598A1 (fr) 2008-09-24
AR057985A1 (es) 2008-01-09
TW200800966A (en) 2008-01-01
WO2007061670A1 (fr) 2007-05-31
JP5274258B2 (ja) 2013-08-28

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MKLA Lapsed

Effective date: 20151113