CA2596588A1 - Silencage nucleique de gene de maladie d'huntington - Google Patents

Silencage nucleique de gene de maladie d'huntington Download PDF

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Publication number: CA2596588A1
Authority: CA; Canada
Prior art keywords: seq; sirna; strand; rna; expression
Prior art date: 2005-01-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CA002596588A

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English (en)

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CA2596588C (fr

Inventor

Beverly L. Davidson

Scott Harper

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

University of Iowa Research Foundation UIRF

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Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-01-31

Filing date

2006-01-31

Publication date

2006-08-10

2005-01-31 Priority claimed from US11/048,627 external-priority patent/US20050255086A1/en

2006-01-31 Application filed by Individual filed Critical Individual

2006-08-10 Publication of CA2596588A1 publication Critical patent/CA2596588A1/fr

2017-06-27 Application granted granted Critical

2017-06-27 Publication of CA2596588C publication Critical patent/CA2596588C/fr

Status Active legal-status Critical Current

2026-01-31 Anticipated expiration legal-status Critical

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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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CA2596588A 2005-01-31 2006-01-31 Silencage nucleique de gene de maladie d'huntington Active CA2596588C (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US11/048,627 US20050255086A1 (en)	2002-08-05	2005-01-31	Nucleic acid silencing of Huntington's Disease gene
US11/048,627		2005-01-31
PCT/US2006/003298 WO2006083800A2 (fr)	2005-01-31	2006-01-31	Silençage nucleique de gene de maladie d'huntington

Publications (2)

Publication Number	Publication Date
CA2596588A1 true CA2596588A1 (fr)	2006-08-10
CA2596588C CA2596588C (fr)	2017-06-27

Family

ID=36777811

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA2596588A Active CA2596588C (fr)	2005-01-31	2006-01-31	Silencage nucleique de gene de maladie d'huntington

Country Status (4)

Country	Link
EP (1)	EP1844148A2 (fr)
AU (1)	AU2006210973A1 (fr)
CA (1)	CA2596588C (fr)
WO (1)	WO2006083800A2 (fr)

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JP2002166817A (ja)	1999-10-01	2002-06-11	Daicel Chem Ind Ltd	ハイブリッドインフレータ
US20040241854A1 (en)	2002-08-05	2004-12-02	Davidson Beverly L.	siRNA-mediated gene silencing
US20050042646A1 (en)	2002-08-05	2005-02-24	Davidson Beverly L.	RNA interference suppresion of neurodegenerative diseases and methods of use thereof
US20080274989A1 (en)	2002-08-05	2008-11-06	University Of Iowa Research Foundation	Rna Interference Suppression of Neurodegenerative Diseases and Methods of Use Thereof
US20080039415A1 (en) *	2006-08-11	2008-02-14	Gregory Robert Stewart	Retrograde transport of sirna and therapeutic uses to treat neurologic disorders
WO2008018795A1 (fr)	2006-08-11	2008-02-14	Prosensa Technologies B.V.	Procédés et moyens de traitement de troubles génétiques associés à l'instabilité des répétitions de l'ADN
CA2688514A1 (fr)	2007-04-26	2008-11-06	University Of Iowa Research Foundation	Suppression de l'interference par l'arn des maladies neurodegeneratives et ses methodes d'utilisation
AU2008260103B2 (en)	2007-05-31	2014-04-03	University Of Iowa Research Foundation	Reduction of off-target RNA interference toxicity
DK2167136T3 (en)	2007-07-12	2016-07-25	Biomarin Tech Bv	Molecules for targeting compounds at different selected organs or tissues
EP2167135A2 (fr)	2007-07-12	2010-03-31	Prosensa Technologies B.V.	Molécules pour cibler les composants vers plusieurs organes sélectionnés, tissus ou cellules de tumeurs
USRE48468E1 (en)	2007-10-26	2021-03-16	Biomarin Technologies B.V.	Means and methods for counteracting muscle disorders
NZ584793A (en)	2007-10-26	2012-05-25	Academisch Ziekenhuis Leiden	Means and methods for counteracting muscle disorders
NZ587178A (en)	2008-02-08	2011-11-25	Prosensa Holding Bv	Methods and means for treating dna repeat instability associated genetic disorders
EP2119783A1 (fr)	2008-05-14	2009-11-18	Prosensa Technologies B.V.	Procédé pour l'omission efficace de l'exon (44) dans la dystrophie musculaire de Duchenne et moyens connexes
JP2012524540A (ja)	2009-04-24	2012-10-18	プロセンサテクノロジーズビー．ブイ．	Ｄｍｄを処置するためのイノシンを含むオリゴヌクレオチド
WO2012109667A1 (fr)	2011-02-12	2012-08-16	University Of Iowa Research Foundation	Composés thérapeutiques
EP2806900B1 (fr)	2012-01-27	2021-12-15	BioMarin Technologies B.V.	Oligonucléotides de modulation arn ayant des caractéristiques améliorées pour le traitement de la dystrophie musculaire de duchenne et becker
SI2841578T1 (sl)	2012-04-23	2017-12-29	Biomarin Technologies B.V.	Rna modulirajoči oligonukleotidi z izboljšanimi karakteristikami za zdravljenje nevromuskularnih motenj
JP6628285B2 (ja)	2013-03-14	2020-01-08	ユニバーシティオブフロリダリサーチファンデーションインコーポレーティッド	Ａｌｓ関連ジアミノ酸リピート含有タンパク質
CA2949437C (fr)	2014-05-20	2023-08-15	University Of Iowa Research Foundation	Composes therapeutiques pour la maladie de huntington
US10509045B2 (en)	2015-05-29	2019-12-17	University Of Florida Research Foundation, Incorporated	Methods for diagnosing Huntington's disease
US10940161B2 (en)	2016-04-04	2021-03-09	University Of Florida Research Foundation, Incorporated	Manipulation of EIF3 to modulate repeat associated non-ATG (RAN) translation
JP7220080B2 (ja)	2016-05-18	2023-02-09	ボイジャーセラピューティクスインコーポレイテッド	ハンチントン病治療組成物及び方法
CA3060250A1 (fr)	2017-04-17	2018-10-25	University Of Florida Research Foundation, Incorporated	Regulation de la traduction de la proteine ran par les voies pkr et eif2a-p
KR20200056428A (ko) *	2017-09-22	2020-05-22	젠자임 코포레이션	변이체 RNAi
CA3076214A1 (fr)	2017-09-26	2019-04-04	University Of Florida Research Foundation, Incorporated	Utilisation de metformine et d'analogues de celle-ci pour reduire les taux de proteine ran lors d'un traitement de troubles neurologiques
KR20200075865A (ko) *	2017-10-23	2020-06-26	프리베일 테라퓨틱스, 인크.	신경변성 질환에 대한 유전자 요법
CN112980837B (zh) *	2019-12-13	2023-07-04	深圳艾码生物科技有限公司	一种抑制HTT基因表达的siRNA及其前体和应用

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20050106731A1 (en) *	2002-08-05	2005-05-19	Davidson Beverly L.	siRNA-mediated gene silencing with viral vectors
US20050255086A1 (en) *	2002-08-05	2005-11-17	Davidson Beverly L	Nucleic acid silencing of Huntington's Disease gene
US20050042646A1 (en) *	2002-08-05	2005-02-24	Davidson Beverly L.	RNA interference suppresion of neurodegenerative diseases and methods of use thereof
US7605249B2 (en) *	2002-11-26	2009-10-20	Medtronic, Inc.	Treatment of neurodegenerative disease through intracranial delivery of siRNA
WO2005105995A2 (fr) *	2004-04-14	2005-11-10	Sirna Therapeutics, Inc.	Traitement de maladies a expansion de sequence repetee de polyglutamine (polyq) a mediation d'arn interferent mettant en oeuvre un acide nucleique court interferent (sina)

2006
- 2006-01-31 CA CA2596588A patent/CA2596588C/fr active Active
- 2006-01-31 EP EP06734091A patent/EP1844148A2/fr not_active Withdrawn
- 2006-01-31 WO PCT/US2006/003298 patent/WO2006083800A2/fr active Application Filing
- 2006-01-31 AU AU2006210973A patent/AU2006210973A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1844148A2 (fr)	2007-10-17
CA2596588C (fr)	2017-06-27
WO2006083800A2 (fr)	2006-08-10
WO2006083800A3 (fr)	2007-03-01
AU2006210973A1 (en)	2006-08-10

Legal Events

Date	Code	Title	Description
2011-01-28	EEER	Examination request

Publication	Publication Date	Title
US10072264B2 (en)	2018-09-11	RNA interference suppression of neurodegenerative diseases and methods of use
CA2596588C (fr)	2017-06-27	Silencage nucleique de gene de maladie d'huntington
US20050255086A1 (en)	2005-11-17	Nucleic acid silencing of Huntington's Disease gene
US8524879B2 (en)	2013-09-03	RNA interference suppresion of neurodegenerative diseases and methods of use thereof
US8779116B2 (en)	2014-07-15	SiRNA-mediated gene silencing
AU2009202278B2 (en)	2012-09-06	Allele-specific sirna-mediated gene silencing
US10006028B2 (en)	2018-06-26	Alternative export pathways for vector expressed RNA interference
US20080176812A1 (en)	2008-07-24	Allele-specific silencing of disease genes
US20090105169A1 (en)	2009-04-23	Allele-specific silencing of disease genes
AU2005200827B2 (en)	2005-07-14	Allele-specific siRNA-mediated gene silencing
EP1581635A2 (fr)	2005-10-05	Mise au silence de genes a mediation par sirna