CA2569080A1 - Anti-coronavirus molecules and their use in compositions and methods for treating and/or preventing infection caused by a coronavirus - Google Patents

Abstract

The present invention relates to the field of coronavirus and more particularly to anti-coronavirus molecules and their use in compositions and methods for treating and/or preventing infection caused by a coronavirus such as the one responsible for SARS. The present invention also relates to a method for screening new anti-coronavirus molecules.

Description

ANTI-CORONAVIRUS MOLECULES AND THEIR USE IN COMPOSITIONS AND
METHODS FOR TREATING AND/OR PREVENTING INFECTION CAUSED BY A
CORONAVIRUS

FIELD OF THE INVENTION

The present invention relates to the field of coronavirus and more particularly to anti-coronavirus molecules and their use in compositions and methods for treating and/or preventing infection caused by a coronavirus such as the one responsible for SARS. The present invention also relates to a method for screening new anti-coronavirus molecules.

BRIEF DESCRIPTION OF THE PRIOR ART

Coronaviruses are found in a wide variety of animals and can cause disorders of diverse severity. Considering the number of recently discovered human and animal coronaviruses, including the highly pathogenic virus responsible of the SARS
syndrome (SARS-CoV), research on novel antiviral strategies against coronaviruses is a priority (Peiris et al., 2003; Rota et al., 2003;; Woo et al., 2005; Woo et al., 2006).
Understanding mechanisms elaborated by viruses to hijack or exploit cellular pathways is a clue to identify novel cellular targets (Marsh and Helenius, 2006). Very little is known about molecular interactions occurring between viral and cellular proteins during the entry and assembly/buddiing processes of coronaviruses (de Haan and Rottier, 2006). The cytosolic tails (CT) of viral envelope proteins are accessible to cellular machineries during production, maturation, trafficking, and assembly of viral envelope proteins (pre-buddirig steps) as well as during the viral particle fusion and post-fusion events (entry steps) (Nal et al., Journal of general Virology, 2005). The inventors have hypothesized that targeting cellular partners of the CT region of SARS-CoV Spike, E and M envelope proteins may not only alter maturation and trafficking properties of viral proteins but also disrupt crucial steps of SARS-CoV life cycle and consequently affects its infectivity.

There is therefore a need in the art for new coronavirus treatments or vaccines that elicit a broad, long-lasting and neutralizing protective response. There is also a need to provide for new methods for screening anti-coronavirus molecules with regards to coronavirus infections.

DEFINITIONS
Throughout the specification, several ternns are employed, that are defined in the following paragraphs.

In the context of the present invention, the term "viral interacting protein"
refers to any protein of coronavirus origin that binds to an eukaryotic cells in such a way that the binding interaction is important or essential in the viral life cycle of a coronavirus.

The terms "peptide" and "polypeptide" are used herein interchangeably. They refer to sequences of more than three amirio acids. Preferably, peptides are sequences of less than about 250 amino acids, particularly, less than 100, 75, 50, and 30 amino acids. Preferred peptides of the invention contain in the range of about 5-50, 7-30, or 15-25 amino acids.

As used herein, the term "amino acid" refers to a monomeric unit of a protein.
There are twenty amino acids found in naturally occurring proteins, all of which are L-isomers. The term "amino acid" may also include analogs of the amino acids, D-isomers of the protein amino acids and their analogs.

The term "isolated" when applied to interacting and specificity peptides of the present invention means a peptide or a portion thereof, which, by virtue of its origin or manipulation, (a) is present in a host cell as the expression product of a portion of an expression vector; (b) is linked to a protein or chemical moiety other than that to which it is linked in nature; (c) does not occur in nature, or (d) is such that its manufacture or production involved the hand of man. By "isolated" it is, alternatively or additionally, meant that the peptide of interest is chemically synthesized;
or expressed in a host cell and purified away from at least some other proteins.
Preferably, the peptide is also separated from substances such as antibodies or gel matrices (polyacrylamide) which are used to purify it.

The terms "inhibitor" and "inhibitory ageint" are used herein interchangeably.
They refer to a compound, molecule or factor ttiat has been identified as capable of inhibiting a coronavirus protein- eucaryotic cell protein binding interactions which are important or essential to the life cycle of a cororiavirus. Preferred inhibitory agents of the invention inhibit the life cycle of a coronavirus responsible of SARS.

The term "molecule", as used herein, refers to any natural or synthetic organic compound or factor with a molecular weight preferably less than about 600-700 Daltons.

As used herein, the term "coronavirus disease" refers to any kind of infection or disorder caused by a coronavirus. Thus, the term includes symptoms and side effects of any coronavirus infection, including latent, persistent and sub-clinical infections, whether or not the infection is clinically apparent.

As used herein, the term "treatment" refers to administration of an anti-viral agent to a patient (who is either the host of a coronavirus infection or may be at risk of being infected by a coronavirus). If it is administered prior to exposure to the virus, the treatment is preventive or prophylactic (i.e., it protects the patient against infection), whereas if the adrninistration is performed after infection or initiation of the disease, the treatment is therapeutic (i.e., it combats the existing infection).

The term "individual" refers to a human or another mammal that can be the host of a coronavirus, but may or may not be infected by the virus.

A "pharmaceutical composition", as used herein, is defined as comprising an effective amount of at least one inhibitory molecule of the invention, or a physiologically tolerable salt thereof, and at least one pharmaceutically acceptable carrier.

As used herein, the term "effective aniount" refers to any amount of an inhibitory molecule, or pharmaceutical composition thereof, that is sufficient to fulfill its intended purpose(s). For example, the purpose(s) may be: to protect against infection by a coronavirus; to combat a coronavirus; to prevent the onset of a disease caused by the coronavirus; to slow down or stop the progression, aggravation, or deterioration of the symptoms of a coronavirus disease; to bring about amelioration of the symptoms of the disease; or to cure the disease.

As used herein, the term "cellular interacting protein" refers to a human or an animal protein or a fragment of a said protein wich interacts with at least a SARS-COV viral protein among as S, N, M or E protein c-terminal domains. The interaction can be obtained by using as an example the Yeast Two-Hybrid (Y2H) assay.

Additional definitions are provided throughout the Detailed Description.

DETAILED DESCRIPTION OF THE INVENTION

The present invention relates to the identification and/or use of anti-coronavirus molecules or agents. In particular, the invention relates to the identification and/or use of anti-coronavirus molecules that inhibit or disrupt viral protein- cellular protein interactions that are important or essential in the viral life cycle of a coronavirus.

In one aspect of the invention, there is provided a method of screening for anti-coronavirus molecules comprising the steps of :

a) providing a collection of antiviral candidate molecules;

b) contacting a candidate antiviral molecule with at least one coronavirus protein or a fragment thereof to obtain a mixture;

c) adding to said mixture, a determined cellular interacting protein or fragment thereof;

d) determining whether said candidate aritiviral protein reduces or inhibits the binding interaction between the coronavirus protein and said cytoskeleton protein or 5 fragment thereof; and e) identifying said candidate antiviral molecule.

As will be appreciated by those of ordinary skill in the art, any kind of compounds, moiecules or factors can be tested using the inventive screening method. In certain embodiments, small molecules (i.e., any natural or synthetic organic compounds or factors with a molecular weight preferably lower than about 600-700 Daltons) are tested using the inventive method. In other embodiments, the inventive method is used for screening small molecule collections or libraries. Any collection or library of molecules can be screened using the method provided herein.
As used herein, the term "collection" refers to any set of compounds, molecules, or agents, while the term "library" refers to any set of structural analogs of compounds, molecules or agents.

As will be appreciated by those of ordinary skill in the art, the binding interaction between the coronavirus protein and said cellular interacting protein is advantegeously important in the life cycle of a coronavirus, such as a coronavirus responsible of Severe Acute Respiratory Syndronie Coronavirus (SARS-Co-V).

In preferred embodiments, the coronavirus protein is the SARS-CoV Spike protein and a fragment of the coronavirus is the Spike cytosolic tail. In this connection, the Spike cytosolic tail has the amino acid sequence CCMTSCCSCLKGACSCGSCCKFDEDDSEPVLKGVKLHYT.

As will be appreciated by those of ordinary skill in the art, the contemplated cellular interacting protein or a fragment thereof by the present invention is preferably obtained from a cell lysate. According to another preferred embodiment, the contemplated cellular interacting protein or a fragment thereof is a purified cellular interacting protein or a fragment thereof.

As will be appreciated by those of ordiriary skill in the art, the determined cytoskeleton protein of the ERM family ezrin, radixine and moesin preferably comprises a FERM domain, such as the cytoskeleton proteins selected from the group consisting of ezrin, radixine, protein 4.1 and moesin. In this connection, the ezrin protein has preferably the amino acid sequence NVRVTTMDAELEFAIQPNTTGKQLFDQWKTIGLREVWYFGLHYVDNKGFPTWLKL
DKKVSAQEVRKENPLQFKFRAKFYPEDVAEEL.
According to another preferred embodiment, the cytoskeleton protein is selected from the group consisting of E-cadherine and alpha 5 integrin, and where as the E-cadherin has preferably the amino acid sequence SRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFED
CTGRQRTAYFSLD and the alpha5 integrin has preferably the amino acid sequence PLLPLLLLLLPPPPRVGGFNLDAEAPAVLSGPPGSFFGFSVEFYRPGTDGVSVLVG
APKANTSQPGVLQGGAVYLCPWGASPTQCTPIEFDSKGSRLLESSLSSSEGEEPV
EYKSLQW FGATVRAHGSSI LACAPLYSW RTEKEPLSDPVGTCYLSTDNFTRILEYA
PCRSDFSWAAGQGYCQGGFSAEFTKTGRVVLGGPGSYFWQGQILSATQEQIAES
YYPEYLINLVQGQLQTRQASSIYDDSYLGYSVAVGEFSGDDTEDFVAGVPKGNLTY
GYVTILNGSDIRSLYNFSGEQMASYFGYAVAATD.
In accordance with another preferred embodiment of the invention, the coronavirus protein is the SARS-CoV E protein or a fragment thereof. In this connection, the fragment of the coronavirus is pneferably the E cytosolic tail (E CT), which has advantageously the amino acid sequence LTALR LCAYC CNIVN VSLVK
PTVYV YSRVK NLNSS EGVPD LLV.

As will be appreciated by those of ordinary skill in the art, the PDZ domain containing cellular interacting protein may be the PALS1 (MPP5) protein or fragment thereof. In this connection, the PALS1 protein preferably comprises the amino acid sequence LEPIKEERVYESVGQYGRKTVKIVRKEEARDIPLGATVHKEMDSVIISRIVRGAAAEK
SGLLHERDDVLKINGVESREKDINEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIH
VKAHFDYDPSDDPYVPCRELGLSFQKGDILHVIS.
Yet, according to another preferred embodiment of the invention, the coronavirus protein is the SARS-CoV M protein or a fragment thereof. More specifically, the fragment of the coronavirus is the M cytosolic tail (M CT), and has preferably the following amino acid sequence :
LFARTRSMWSFNPETNILLNVPLRGTIVTRPLMESELVIGAVIIRGHLRMAGHSLGRC
DIKDLPKEITVATSRTLSYYKLGASQRVGTDSGFAAYNRYRIGNYKLNTDHAGSNDN
IALLVQ

A further preferred embodiment of the invention is that the cytoskeleton-linked cellular interacting protein is the cellular DIP/SPIN90 protein or fragment thereof, and preferably has the following amino acid sequence ELVRRNTGLSHELCRVAlGI
IVGHIQASVPASSP'VMEQVLLSLVEGKDLSMALPSGQ
VCHDQQRLEVIFADLARRKDDAQQRSWALYEDEGVIRCYLEELLHILTDADPEVCK
KMCKRNEFESVLALVAYYQMEHRASLRLLLLKCFGAMCSLDAAI ISTLVSSVLP.

Another aspect of the invention concerris an anti-coronavirus composition comprising at least one purified cytoskeleton protein or a fragment thereof and/or an antiviral molecule obtained by the screening method of the invention.

A further aspect of the invention concerris a composition for the treatment and/or prevention of infection caused by a coronavirus, the composition comprising:

- at least one coronavirus protein or fragments thereof selected from the group of protein consisting of S, M and E, and - at least one cellular protein or fragments thereof.

As will be appreciated by those of ordinary skill in the art, the contemplated coronavirus proteins and/or cellular interacting proteins as defined above are useful to reduce or inhibit an infection of human cells caused by a coronavirus.
Furthermore, the contemplated coronavirus proteins and/or cellular interacting proteins as defined above are usefull for the treatment and/or prevention of of infection caused by a coronavirus.

Yet, those of ordinary skill in the art will appreciate the above contemplated coronavirus proteins and/or cellular interacting proteins are particularly useful in the preparation of a composition in the treatmeni: and/or prevention of of infection caused by a coronavirus.

The present inventiori will be more readily understood by referring to the following example. This example is illustrative of the wide range of applicability of the present invention and is not intended to limit its scope. Modifications and variations can be made therein without departing from the spirit and scope of the invention.
Although any methods and rnaterials similar or equivalent to those described herein can be used in the practice for testing of the present invention, the preferred methods and materials are described.

EXAMPLES
Summary Using a large-scale yeast two-hybrid screening strategy (Hybrigenics company, Paris), the inventors have identified cellular factors that interact with SARS-CoV Spike, E and M envelope protein CT. In particular, the inventors identified ezrin (ERM protein) and PALS1 (PDZ domain-containing protein) proteins with significantly high confidence scores for interaction with the CT domains of Spike and E, respectively. Both E:zrin and PALS1 i/ belong to families of scaffolding proteins specialized in the functional organization of specific plasma-membrane domains by providing a link between filamentous actin and membrane proteins;
ii/

are involved in signal transduction and iii/ have been found functionally linked to the regulation of polarized epithelial secretion in gastric parietal cells (Cao et al., 2005;
Gautreau et al., 2000; Roumier et al., 2001; Straight et al., 2006).
Involvement of ERM actin-binding proteins in microbial infections has been occasionally reported during the entry, trafficking and spreading processes of bacteria (Pust et al., 2005;
Tran Van Nhieu et al., 2000). In the same line, the cell cytoskeleton is implicated at several stages of the viral life cycle and cytoskeletal proteins including ERM
proteins have been isolated from viral particles, which support the hypothesis that interactions between cell actin cytoskeleton components andl viral proteins are implicated in viral assembly and budding (Dohner and Sodeik, 2005; Matarrese and Malorni, 2005;
Ott et al., 1996).

In the past few months the inventors focused on the characterisation of Spike CT (aa 1216-1255) interaction with ezrin. The inventors determined that the subdomain Fl of the ezrin N-terminal FERM region is the binding site for SARS-Spike CT. The ezrin-Spike interaction was confirmed by pull-down experiments.
Interestingly, we showed that ezrin subcellular distribution is drastically affected in VeroE6 cells infected by SARS-CoV. Although ezrin is enriched in subcortical areas of the cell in normal conditions, it is recruited to ERGIC/Golgi apparatus compartments where Spike concentrates in infected cells. These compartments are the sites of coronavirus assembly and budding, which suggests a potential role of ezrin in these events. Furthermore, the inventors found that entry of Spike-pseudotyped lentiviral particles (SARSpp), which mimics entry steps of SARS
CoV
(Kam, Kien, Roberts et al.,Vaccine 2006; Wang et al., Biochem Biophys Res Comm, 2004, vol 315, pp439-444), is significantly enhanced in cells treated with small interfering RNAs (siRNA) targeting ezrin.

More recently, the inventors have started similar studies with the objective to understand the functional relevance of the interaction between E CT (aa 34-76) of SARS-CoV and the PALS1 protein. The inventors have identified that E CT
interacts with a region of PALS1 that contains the PDZ domain and a portion of the SH3 domain. The 4 last amino acids of the E CT domain share strong similarities with the consensual PDZ binding motif and 2 other clones coding for other PDZ
containing proteins were also isolated from the screen. Interestingly, it was reported recently that the PDZ ligand motif at the C-terminus end of the H5N1 highly pathogenic avian influenza NS1 protein is a potential virulence determinant (Obenauer et al.,Science 2006, vol 311, p p 1576 ).

General Materials & Methods.
Cells Les cellules utilisees dans les experiences sont les suivantes : celluies foetales de 10 rein humain HEK 293T, cellules epitheliales derivees d'un carcinome uterin humain HeLa et exprimant de faron stable le recepteur ACE2 du SRAS-CoV (HeLa-F5, Wang et al., 2004), ou le recepteur CD4 et le co-recepteur CXCR4 du VIH (HeLa-P4) (Clavel et al., 1994). Elles sont cultivees dans le milieu DMEM contenant du Glutamax I et du Pyruvate de Sodium (Gibco BRL), complemente avec 5% de serum de veau foetal et en presence de 100 U.mL-1 de penicilline et 100 pg.mL-1 de streptomycine. Elles sont incubees a 37 C en atmosphere humide ajustee a 5% de C02.

Plasmids Le plasmide pCDNA-opt S-FLAG contient une sequence nucleotidique optimisee pour l'usage de codons humains codant Ia proteine S du SRAS-CoV. Cette sequence est. L'ADNc codant le peptide FLAG M2 (DYKDDDDK) est introduit en phase en 3' de I'ADNc codant S. Le plasmide pGEX-GST S Cterm a ete construit a partir du plasmide pGEX-4T'1 (Pharmacia Biotech). L'ADNc codant Ia region C-terminale (aa 1216-1255) de Ia proteine S du SRAS-CoV a ete amplifie par reaction de polymerisation en chaine (PCR) a partir du plasmide pCDNA-opt S-FLAG.
L'introduction des sites de restriction BamHl et Xhol en 5' et 3' de I'ADNc lors de I'etape de PCR (oligonuclEotide sens GTTAGGATCCTGTTGCATGACCTCC ;
oligonucleotide antisens comprenant un codon stop:
GTAGCTCGAGTCATGTGTAATGCAGCTT) a permis le sous-clonage de I'ADNc de S Cterm en phase avec I'ADNc de Ia Glutathione S-transferase (GST). Le plasmide pGEX-GST FERM, codant Ia GSTqui a ete fusionnee a Ia sequence du domaine FERMde 1'ezrine (aa 1-309) a ete construit. Le vecteur pNL4.3.Luc-R-E-pro contenant Ia sequence du provirus du VIH Aenv Anef et le gene rapporteur luciferase a ete fourni par P. Charneau de I'Institut Pasteur, Paris.
Antibodies Les anticorps utilises dans les differentes experiences sont les suivants : le serum de lapin immunise avec un peptide de I'ezrine et les immunoglobulines purifiees. Le serum de souris immunisees avec la proteine S a ete fourni par J. Kam (HKU-Pasteur Research Centre). Le serum de lapin immunises avec le domaine C-terminal de S est fourni par Proscience. Les anticorps monoclonaux de chevre dirige contre Ia radixine (IgG, C-15) proviennent de Santa Cruz Biotechnologies. Les anticorps monocionaux de souris reconnaissant ERGIC-53 sont d'isotype IgG1 et ont ete fournis par H.P. Hauri. Les anticorps monocionaux de souris diriges contre Ia proteine Golgi 58K sont d'isotype IgG1 et proviennent d'Abcam. Les anticorps monocionaux de souris diriges contre la proteine GAPDH (Glyceraldehyde 3 phosphate dehydrogenase) sont d'isotype IgG1 et proviennent d'Abcam.
Co-precipitation de I'ezrine par la methode GST Pull Down Production de proteines de fusion : des bacteries electrocompetentes BL21-Gold (DE3)pLysS (Stratagene) sorit transformees par electroporation avec les plasmides PGEX GST-S Cterm et PGEX GST-FERM. Des clones de bacteries sont ensuite incubees en milieu liquide Luria Broth (LB) en pre-sence d'ampicilline.
L'induction de Ia production des proteines de fusion est r6alisee en ajoutant 1mM d'IPTG
(Isopropyl-Thio-_-D-Galactopyranoside) au milieu de culture. Les bacteries sont incubees dans ce milieu pendant 2 heures a 37 C:. Elles sont ensuite centrifugees, a 7 000 g pendant 5 min a 4 C. Le culot est resuspendu dans 1 mL de tampon de lyse (400 mM NaCI, 50 mM Tris, 1 mM DTT, 0,3% Triton X-100, PMSF 0,6 mM). Pour accelerer la lyse des bacteries, les echantillons subissent un choc rapide de congelation/decongelation et sont soniques avec 5 impulsions d'amplitude maximale de 15 s, sur glace. Le lysat est centrifuge 6 14 000 g pendant 20 min 6 4 C
pour eliminer les debris bacteriens et les proteines insolubles. Le surnageant contenant les proteines solubles est conserve.

Preparation des billes de sepharose : les billes de sepharose-glutathione (Glutathione SepharoseTM 4B, Amersham Biosciences) sont sedimentees a 500 g pendant 5 min. Elles sont ensuite rincees 3 fois avec 1 mL de tampon de lyse froid (150 mM NaCi, 50 mM Tris, 0,1% Triton X-100, PMSF 1 mM, BSA 50 microglmL).
Les billes sont resuspendues dans 100 micro/L de ce tampon de lyse.

Couplage des proteines de fusion sur les billes de s6pharose-glutathione :
les surnageants bacteriens sont incubes avec 10 micro/L de billes de sepharose-glutathione pendant 2 h a 4 C pour immobiliser les proteines de fusion solubilisees sur les billes. Enfin, les billes sont rincees 3 fois avec le tampon de lyse suivant : 150 mM NaCI, 50 mM Tris, 0,2% Triton X-100, PMSF 1 mM, BSA 50 microg/mL.
Pr6paration de lysats de celluies HeLa et Vero-E6. La lyse s'effectue sur glace, pendant 15 min avec le tampon suivant : 0,5% Triton-X100, 150 mM NaC1, 20 mM
Tris, 1 mM EDTA, 50 mM NaF, PIC 1 X, 1 mM PEFABIoc sur des cellules ensemencees Ia veille et qui sont a une confluence de 70%. Le lysat est centrifuge a 10 000 g pendant 10 min a 4 C et le culot est elimine. 500 micro/L des lysats sont rajoutes aux billes sepharose-glutathione couplees aux proteines de fusion. Le melange est incube 3 heures a 4 C. Les billes sont ensuite rincees 5 fois avec uL de tampon pour lyse cellulaire. Elles sont ensuite melangees au tampon de charge NuPage LDS Loading Buffer (Invitrogen) en presence de DTT
(dithiothreitol) a 10 mM final. Les echantillons sont ensuite analyses par western blot (comme decrit dans le paragraphe 226).

Microscopie confocale pour observation de co-localisations Des lames recouvertes de cellules Vero-E6 infectees ou non par le virus SRASCoV
(Euroimmun) sont permeabilisees et subissent un blocage en les incubant 30 min dans une solution de PBS - Tween 20 a 0,2 % complementee a 10% avec du serum inactive de chevre (NGS) ou du serum inactive de veau foetal (FCS). Un premier marquage est effectue en incubant les lamelles pendant 45 min avec differentes combinaisons de solutions d'anticorps suivantes : serum de souris immunisee avec Ia proteine S(1/100), anticorps de lapin anti-S (1/100), anticorps de lapin anti-ezrine (1/1000), anticorps de souris anti-golgi 58K (1/50), anticorps de chevre anti-radixine (1/50), anticorps de souris anti-Ergic 53 (1/1000). Les lames sont ensuite lavees dans une solution de PBST 0,2% sous agitation pendant 5 min. Les lames sont incubees pendant 30 min avec les anticorps secondaires suivants : anticorps de chevre anti-IgG de lapin couples au FITC (Imrriuno Research 1/100), anticorps de chevre anti-IgG de souris couples au Texas Red (Oncogene, 1/100), anticorps de lapin anti-IgG de chevre coup!e au FITC. Toutes les dilutions d'anticorps s'effectuent avec une solution de PBSTween 20 0,2% complementee a 5% avec du serum inactive de chevre (NGS) ou du serum inactive de veau foetal (FCS) (pour les marquages radixine). Les lames sont de nouveau rincees pendant 5 min dans une solution de PBS-Tween 20 a 0,2%. Elles sont ensuite incubees dans une solution contenant le marqueur de noyaux DAPI (4',6-Diamidino-2-phenyfindofe). Les !amelles sont ensuite montees sur les lames avec le milieu de montage Vectashield (Vector laboratories). Elles sont conservees a 4 C. L'analyse des echantillons s'effectue a I'aide d'un microscope Zeiss 200M equipe d'un systeme confocal LSM510, avec un objectif a immersion d'huile Plan APOCHROMAT xlOO (Zeiss), et de lasers Argon (longueur d'onde d'excitation: 454, 488, 514 nm) et Helium-Neon (longueur d'onde , d'excitation: 543 nm). Cette analyse a ete effectuee au departement d'anatomie de l'Universite de Hong Kong.

Production de particules pseudotypees Des boites de Petri 100 mm de diametre sont ensemencees avec 2,5.106 cellu!es HEK-293T. Apres 24 h d'incubation a 37 C en atmosphere humide ajustee a 5% de C02, le milieu de culture est remplace par du milieu complet frais. Les celluies sont alors transfectees via l'utilisation du systeme de transfection CalPhos Mammalian Transfection Kit (Clontech). La production de particules lentivirales pseudotypees par la proteine S de SRAS-CoV est obtenue par l'utilisation d'un systeme d'expression dit a 2 plasmides. Ceux-ci, pNL4.3.Luc R-E-pro- et pcDNA-opt S -FLAG, sont transfectes a un ratio 10:10, c'est-a-dire que 10 pg de plasmide pNL4.3.Luc R-E-pro- et 10 pg de plasmide pcDNA-opt S FLAG sont simultanement transfectees dans les cellules HEK-293T. 36 h a 40 h apres transfection, le milieu de culture est preleve, centrifuge a 2 000 g pendant 10 min a 4 C puis filtre a travers une membrane dont Ia taille des pores est de 0,45 pm. Les solutions de particules filtrees sont ensuite aliquotees et stockees a-80 C. Les particules lentivirales pseudotypees avec Ia glycoproteine G du virus de Ia stomatite vesiculaire, Ia glycoproteine gp120/gp41 du VIH ont ete obtenues par F. Kien et JM Garcia respectivement (HKU-Pasteur Research Centre)., Culture cellulaire et traitement par ARN interf6rant (ARNi) Les traitements aux ARNi sont effectues en transfectant les cellules HeLa-F5 et HeLa-P4 avec des melanges de quatre oligonucleotides (Dharmacon Life Technologies, sequences non communiquees) qui ciblent specifiquement soit les ARNm de 1'ezrine (numero d'accession NCBI de la sequence de I'ADNc sur laquelle Ia synthese des oligonucleotides est fondee : NM_003379) soit les ARNm de la radixine (numero d'accession NCBI de la sequence de I'ADNc sur laquelle Ia synthese des oligonucleotides est fondee : NM_002906). 3.103 celluies par puits sont ensemencees dans des plaques de 96 puits. 24 h apres, une premiere transfection est effectuee avec, pour chaque puits, 0,2 micro/L du reactif de transfection Dharmafect 2' (Dharmacon Life Technologies) et 5 micro/L
d'oligonucleotides ARNi a 2 rnM pour avoir une concentration finale de 100 nM
dans un volume final de 100 micro/L complete avec du DMEM avec du serum de veau fetal a 5% mais sans antibiotiques. Une seconde transfection effectuee dans les memes conditions est realisee 48 heures apres Ia premiere afin d'obtenir une meilleure diminution de 1'expression de ces proteines.

Transductions des cellules par les particules lentivirales pseudotypees et mesure de I'activite luciferase 48 h apres la deuxieme transfection aux ARNi, les cellules sont Iavees trois fois dans du milieu DMEM seul. Les particules pseudotypeE:s sont diluees au demi dans le cas des pseudoparticules SRAS, au 1/100 dans le cas des particules pseudotypees avec gp120/gp41 du VIH et au 1/200 dans le cas de particules pseudotypees VSV-G. 50 pL de particules diluees sont ensuite distribuees par puits. Chaque condition est realisee en quatre exemplaires. 12 h apres cet ajout de pseudoparticules, le milieu des cellules est change par du milieu DMEM cornplete avec du serum de veau foetal et les antibiotiques mentionnes precedemment. 48 h apres le changement de milieu, 5 100 pL de reactif BrightGio (Promega) est rajoute par puits. Ce reactif contient un tampon de lyse et le substrat de Ia luciferase. Apres 5 min d'incubation a temperature ambiante, Ia plaque est lue par le d6tecteur de luminescence MicroBeta (PerkinElmer).

10 Quantification de Ia diminution d'expression de proteines par Western Blot Apres lecture de I'activite luciferase, les lysats des differents quadruplicats sont rassembles. 5 pL de tampon de charge (Invitrogen) et 2 N/L DTT
(dithiothreitol) a 200 mM sont rajoutes a 13 p/L de chacun des melanges de lysats. Ces echantillons sont chauffes a 95 C penciant 5 min puis dE!poses sur gels de polyacrylamide 15 NuPAGE Novex Bis-Tris 4-12% (Invitrogen). Apres une electrophorese d'une heure a 200 V et 110 mA dans le tampon de migration MOPS SDS PAGE (Invitrogen), les proteines sont transferees du gel vers des membranes PVDF (Amersham Biosciences) prealablement deshydratees a 1'ethanol et rehydrate dans de 1'eau puis dans le tampon de transfert NuPage Transfer Buffer (Invitrogen). Ce transfert s'effectue pendant 2 heures a 30 V avec un courant allant de 170 a 110 mA dans le tampon de transfert. Les membranes sont par Ia suite Iavees trois fois 10 min dans le tampon Phosphate Buffer Saline (PBS) auquel est ajoute le detergeant Tween a 0,1% (PBST). Les membranes subissent ensi.rite un blocage pendant une heure avec une solution de PBST complete a 5% de lait en poudre ecreme (PBST-Lait).
Les membranes sont alors incubees pendant 2 heures a temperature ambiante avec les anticorps primaires dilues dans une solution PBST-Lait et diriges contre 1'ezrine (dilution au 1/1000ieme) ou Ia radixine (1/100ierne). Cette etape est suivie de trois lavages de 10 min dans le tampon PBST. Les membranes sont ensuite incubees une heure avec les anticorps secondaires diriges contre les Immunoglobulines G
de lapin ou de chevre couples a la peroxidase HRP (Zymed), puis laves comme decrit precedemment. La revelation des proteines s'effectue a I'aide du kit ECL
d'Amersham Bioscience. Les membranes sont placees dans une cassefte de revelation avec un film (Kodak) pendant 5 secondes ou 1 min puis revelees grace au revelateur de films medicaux FujiFilm FPM 100A. Un seconde revelation de proteines s'effectue dans les memes conditions mais en utilisant des anticorps diriges contre des proteines non ciblees par le traitement ARNi : I'actine et la proteine GAPDH. Les bandes des membranes qui correspondent aux proteines d'interet sont quantifiees par analyse densitometrique et ces valeurs sont normalisees par rapport a celles obtenues pour I'actine ou GAPDH.

Example 1: Method for identifying binding inhibitors that inhibit the binding of the C-terminal domains of the S, M, and E viral proteins of the SARS-CoV virus to their identified cellular partners:

Large-scale screening by inhibiting the binding of cellular partners by GST
pull-down :

Production of the GST-S CT, GST-M CT and GST-E CT fusion proteins Electrocompetent bacteria BL21- Gold (DE3) pLysS (Stratagene) are transformed by electroporation with the PGEX GST-S CT, PGEX GST-M CT, PGEX GST-E CT and PGEX GST plasmids. Cloned bacteria are then incubated in a Luria Broth (LB) liquid medium in the presence of ampicillin. The induction of the production of fusion proteins is achieved by adding 1mM IPTG (Isopropyl-Thio-p-D-Galactopyranoside) to the culture medium. The bacteria are incubated in this medium for 2 hours at 37 C.
They are then centrifuged at 7,000 g for 5 min at 4 C. The pellet is resuspended in 1 mL lysis buffer (400 mM NaCl, 50 mM Tris, 1 mM DTT, 0.3% Triton X-100, PMSF
0.6 mM). To accelerate the lysis of the bacteria, the samples undergo a rapid shock through freezing/defreezing and are sonicated with 5 pulses of a maximum amplitude of 15 s on ice. The lysate is centrifuged at 14 000 g for 20 min at 4 C to eliminate bacterial debris and insoluble proteins. The supernantant that contains the soluble proteins is kept.

Binding of fusion proteins to sepharose beads in 96-well plates:
The sepharose-glutathione beads (Glutathione SepharoseTM 4B, Amersham Biosciences) settle at 500 g for 5 min at the bottom of the wells of the 96-well plates.
They are then rinsed 3 times with 1 mL of cold lysis buffer (150 mM NaCI, 50 mM
Tris, 0.1% Triton X-100, PMSF 1 mM, BSA 50 pg/mL). The beads are resuspended in 100 pL of this lysis buffer.

Coupling of fusion proteins to the sepharose-glutathione beads.
The bacterial supernatants are incubated with the sepharose-glutathione beads for 2 hours at 4 C in order to imrriobilize the fusion proteins solubilized onto the beads in the 96-well plate. Finally, the beads are rinsed 3 times with the following lysis buffer:
150 mM NaCI, 50 mM Tris, 0.2% Triton X-100, PMSF 1 mM, BSA 50 Ng/mL.

Preparation of HeLa cell lysates.
Lysis is performed on ice during 15 min with the following lysis buffer: 0.5%
Triton-X100, 150 mM NaCI, 20 mM Tris, 1 mM EDTA, 50 mM NaF, PIC 1X, 1 mM
PEFAB1oc on cells that were inoculated the previous day and that have a confluence of 70%. The lysate is centrifuged at 10 000 g for 10 min at 4 C and the pellet is eliminated.
Screening of banks of inhibitor compounds (including chemical compounds, peptides) The compounds to be screened are added to the 96-well plates containing the fusion proteins GST-S CT, PGEX GST-M CT, PGEX GST-E CT and PGEX GST coupled to the beads (negative controls: well containing only beads and well without beads and without fusion proteins). The plates are incubated with agitation for 30 minutes.

Binding of the proteins contained in the cellular lysate The lysates are added to the sepharose-glutathione beads coupled to the fusion proteins which are pre-incubated with the potential inhibitor compounds. This mixture is incubated for 3 hours at 4 C.

The beads are then rinsed 5 times. The cellular protein of interest is revealed by using a specific primary antibody and a secondary antibody coupled to alkaline phosphatase.The revealing of the protein requires a substrate of the alkaline phosphatase and an ELISA plate reader. The signals are quantified and reflect the binding efficiency of the cellular partner to the C-terminal domain of the S, M and E
viral proteins.

Example 2: Identification of proteins that interact with Sars CoV-S c-terminal domain( HK9) by yeast two-hybrid (Y2H) screening.
Bait cloning and Y2H screening were performed by Hybrigenics, S.A., Paris, France (http://www.hybrigenics.com).

Bait cloning.
HK1 was PCR-amplified and cloned in a Y2H vector optimized by Hybrigenics. The bait construct was checked by sequencing the entire insert, and was subsequently transformed in the L40 GAL4 yeast strain (Fromont-Racine et al. 1997).

Y2H Screening.
A Placenta random-primed cDNA library, transformed into the Y187 yeast strain and containing ten million independent fragments, uvas used for mating. High mating efficiency was obtained by using specific mating method (Legrain et al., 1998, 2000, 2002). The screen was first performed on a small scale to adapt the selective pressure to the intrinsic property of the bait. The bait was found to auto-activate the Y2H system, and 2mM 3-aminotriazole was found to be the optimal concentration to reduce background colonies. Then, the full-scale screen was performed in conditions ensuring a minimum of 50 million interactions tested, in order to cover five times the primary complexity of the yeasttransformed cDNA library (Rain et al. 2001).

millions of interactions were actually tested with HK1. After selection on medium lacking leucine, tryptophane, and histidine, 233 positive clones were picked, and the corresponding prey fragments were amplified by PCR and sequenced at their 5' and 3' junctions. Sequences were then filtered and contiged as described previously (Formstecher et al., 2005) and compared to the latest release of the GenBank database using BLASTN (Altschul et al. 1997). A Predicted Biological Score (PBS) was attributed to assess the reliability of each interaction, as described previously (Formstecher et al., 2005). Briefly, the PBS relies on two different levels of analysis:
firstly a local score takes into account the redundancy and independency of prey fragments, as well as the distributions of reading frames and stop codons in overlapping fragments. Secondly, a global score takes into account the interactions found in all the screens performed at Hybrigenics using the same library. In addition, potential false-positives are flagged by a specific "E" PBS score. This is done by discriminating prey proteins containing "highly connected" domains, previously found several times in screens performed on libraries derived from the same organism.
The PBS scores have been shown to positively correlate with the biological significance of interactions (Rain et al. 2001; Wojcik et al. 2002).

Altschul, S.F., Madden, T.L., Schaffer, A.A., Zhang, J., Zhang, Z., Miller, W., and Lipman, D.J. 1997. Gapped BLAST and PSI-BL_AST: A new generation of protein database search programs. Nucleic Acids Res. 25: 3389-3402.

Formstecher E, Aresta S, Collura V, Hamburger A, Meil A, Trehin A, Reverdy C, Betin V, Maire S, Brun C, Jacq B, Arpin M, Bellaiche Y, Bellusci S, Benaroch P, Bornens M, Chanet R, Chavrier P, Delattre 0, Doye V, Fehon R, Faye G, Galli T, Girault JA, Goud B, de Gunzburg J, Johannes L, Junier MP, Mirouse V, Mukherjee A, Papadopoulo D, Perez F, Plessis A, Rosse C, Saule S, Stoppa-Lyonnet D, Vincent A, White M, Legrain P, Wojcik J, Camonis J, and Daviet L. 2005.
Protein interaction mapping: a Drosophila case study. Genome Res. 15: 376-84 Fromont-Racine, M., Rain, J.C., and Legrain, P. 1997. Toward a functional analysis of the yeast genome through exhaustive two-hybrid screens. Nat. Genet. 16: 277-282.

Legrain et al. (1998; 2000; 2002) US patents No. 6187535, 6531284, 6913886.
Rain, J.C., Selig, L., De Reuse, H., Battaglia, V., Reverdy, C., Simon, S., Lenzen, G., Petel, F., Wojcik, J., Schachter, V., et al. 2001. The protein-protein interaction map of Helicobacter pylori. Nature 409: 211-215.
Wojcik, J., Boneca, I.G., and Legrain, P. 2002. Prediction, assessment and validation of protein interaction maps in bacteria. J. Mol. Biol. 323: 763-770.

Example 3: Identification of proteins that interact with Sars CoV-S c-terminal domain(HK3) by yeast two-hybrid (Y2H) screening. Bait cloning and Y2H
screening were performed by Hybrigenics, S.A., Paris, France (http://www. hybrigenics. com).
Bait cloning.
HK3 was PCR-amplified and cloned in a Y2H vector optimized by Hybrigenics. The bait construct was checked by sequencing the entire insert, and was subsequently transformed in the L40 GAL4 yeast strain (Fromont-Racine et al. 1997).
Y2H Screening.
A Placenta random-primed cDNA library transformed into the Y187 yeast strain and containing ten million independent fragments, was used for mating. High mating efficiency was obtained by using specific mating method (Legrain et al., 1998, 2000, 2002). The screen was first performed on a small scale to adapt the selective pressure to the intrinsic property of the bait. Neither toxicity nor autoactivation of the bait was observed. Then, the full-scale screen was performed in conditions ensuring a minimum of 50 million interactions tested, in order to cover five times the primary complexity of the yeasttransformed cDNA library (Rain et al. 2001). 152 millions of interactions were actually tested with HK3. After selection on medium lacking leucine, tryptophane, and Iiistidine, 62 positive clones were picked, and the corresponding prey fragments were amplified by PCR and sequenced at their 5' and 3' junctions. Sequences were then filtered and contiged as described previously (Formstecher et al., 2005) and compared to the latest release of the GenBank database using BLASTN (Altschul et al. 1997). A Predicted Biological Score (PBS) was attributed to assess the reliability of each interaction, as described previously (Formstecher et al., 2005). Briefly, the PBS relies on two different levels of analysis:

firstly a local score takes into account the redundancy and independency of prey fragments, as well as the distributions of reading frames and stop codons in overlapping fragments. Secondly, a global score takes into account the interactions found in all the screens performed at Hybrigenics using the same library. In addition, potential false-positives are flagged by a specific "E" PBS score. This is done by discriminating prey proteins containing "highly connected" domains, previously found several times in screens performed on libraries derived from the same organism.
The PBS scores have been shown to positively correlate with the biological significance of interactions (Rain et al. 2001; Wojcik et al. 2002). 1997.
Gapped BLAST and PSI-BLAST: A new generation of protein database search programs. Nucleic Acids Res. 25: 3389-3402.

Formstecher E, Aresta S, Collura V, Hamburger A, Meil A, Trehin A, Reverdy C, Betin V, Maire S, Brun C, Jacq B, Arpin M, Bellaiche Y, Bellusci S, Benaroch P, Bornens M, Chanet R, Chavrier P, Delattre 0, Doye V, Fehon R, Faye G, Galli T, Girault JA, Goud B, de Gunzburg J, Johannes L, Junier MP, Mirouse V, Mukherjee A, Papadopoulo D, Perez F, Plessis A, Rosse C, Saule S, Stoppa-Lyonnet D, Vincent A, White M, Legrain P, Wojcik J, Camonis J, and Daviet L. 2005.
Protein interaction mapping: a Drosophila case study. Genome Res. 15: 376-84.
Fromont-Racine, M., Rain, J.C., and Legrain, P. 1997. Toward a functional analysis of the yeast genome through exhaustive two-hybrid screens. Nat. Genet. 16: 277-282.

Legrain et al. (1998; 2000; 2002) US patents No. 6187535, 6531284, 6913886.
Rain, J.C., Selig, L., De Reuse, H., Battaglia, V., Reverdy, C., Simon, S., Lenzen, G., Petel, F., Wojcik, J., Schachter, V., et al. 2001. The protein-protein interaction map of Helicobacter pylori. Nature 409: 211-215.

Wojcik, J., Boneca, I.G., and Legrain, P. 2002. Prediction, assessment and validation of protein interaction maps in bacteria. J. Mol. Biol. 323: 763-770.

Example 4: Identification of proteins that interact with Sars CoV-S c-terminal domain (HK4) by yeast two-hybrid (Y2H) screening. Bait cloning and Y2H
screening were performed by Hybrigenics, S.A., Paris, France (http://www.hybri_genics.co J.

Bait cloning.
HK4 was PCR-amplified and cloned in a Y2H vector optimized by Hybrigenics. The bait construct was checked by sequencing the entire insert, and was subsequently transformed in the L40 GAL4 yeast strain (Fromont-Racine et al. 1997).

Y2H Screening.
A Placenta random-primed cDNA library, transformed into the Y187 yeast strain and containing ten million independent fragments, was used for mating. High mating efficiency was obtained by using specific mating method (Legrain et al., 1998, 2000, 2002). The screen was first performed on a small scale to adapt the selective pressure to the intrinsic property of the bait. Neither toxicity nor autoactivation of the bait was observed. Then, the full-scale screen was performed in conditions ensuring a minimum of 50 million interactions tested, in order to cover five times the primary complexity of the yeasttransformed cDNA library (Rain et al. 2001). 70 millions of interactions were actually tested with HK4. After selection on medium lacking leucine, tryptophane, and histidine, 146 positive clones were picked, and the corresponding prey fragments were amplified by PCR and sequenced at their 5' and 3' junctions. Sequences were then filtered and contiged as described previously (Formstecher et al., 2005) and compared to the latest release of the GenBank database using BLASTN (Altschul et al. 1997). A Predicted Biological Score (PBS) was attributed to assess the reliability of each interaction, as described previously (Formstecher et al., 2005). Brief[y, the PBS re[ies on two different levels of analysis:
firstly a local score takes into account the redundancy and independency of prey fragments, as well global score takes into account the interactions found in all the screens performed at Hybrigenics using the same library. In addition, potential false-positives are flagged by a specific "E" PBS score. This is done by discriminating prey proteins containing "highly connected" domains, previously found several times in screens performed on libraries derived from the same organism. The PBS scores have been shown to positively correlate with the biological significance of interactions (Rain et al. 2001; Wojcik et al. 2002).
Altschul, S.F., Madden, T.L., Schaffer, A.A., Zhang, J., Zhang, Z., Miller, W., and Lipman, D.J. 1997. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs. Nucleic Acids Res. 25: 3389-3402.

Formstecher E, Aresta S, Collura V, Hamburger A, Meil A, Trehin A, Reverdy C, Betin V, Maire S, Brun C, J'acq B, Arpin M, Bellaiche Y, Bellusci S, Benaroch P, Bornens M, Chanet R, Chavrier P, Delattre 0, Doye V, Fehon R, Faye G, Galli T, Girault JA, Goud B, de Gunzburg J, Johannes L, Junier MP, Mirouse V, Mukherjee A, Papadopoulo D, Perez F, Plessis A, Rosse C, Saule S, Stoppa-Lyonnet D, Vincent A, White M, Legrain P, Wojcik J, Camonis J, and Daviet L. 2005.
Protein interaction mapping: a Drosophila case study. Genome Res. 15: 376-84.
Fromont-Racine, M., Rain, J.C., and Legrain, P. 1997. Toward a functional analysis of the yeast genome through exhaustive two-hybrid screens. Nat. Genet. 16: 277-282.

Legrain et al. (1998; 2000; 2002) US patents No. 6187535, 6531284, 6913886.
Rain, J.C., Selig, L., De Reuse, H., Battaglia, V., Reverdy, C., Simon, S., Lenzen, G., Petel, F., Wojcik, J., Schachter, V., et al. 2001. The protein-protein interaction map of Helicobacter pylori. Nature 409: 211-215.

Wojcik, J., Boneca, I.G., and Legrain, P. 2002. Prediction, assessment and validation of protein interaction maps in bacteria. J. Mol. Biol. 323: 763-770.

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m v~ ~ w Role of ERM (ezrin, radixin, moesin) proteins in the life cycle of the Severe Acute Respiratory Syndrome associated Coronavirus (SARS-CoV) DI #
Annex 3 p2 Severe Acute Respiratory Syndrome associated Coronavirus (SARS-CoV) DI #

SARS: first appeared during winter months of 2002-2003 Annex 3 p3 Rapid identification of a novel coronavirus (Peiris et al., 2003) Typical Coronavirus morphology RNA + enveloped virus 100 nm :Major structural proteins: M, N, E, S
__.. ___.... _. _ ..~
=Sitclb_ot=ra,~ it -i. .,.. ='jz., ~ "'~~~FFF
h t R'i nin a-til =nfe - .~, y r 6 r ~-t~i ~ ,.,,;.= , ~ ~~,a ~~,~ d r,''" jy a . ~ ' ~ ~~,;,t 7 """ =
t 4~' op Phylogeny Order: Nidovirales Family: Coronaviridae t~w,..~=
Genus: Coronavirus Group: close to group II Coronaviruses =rn The envelope glycorpotein of SARS-CoV: Spike (S) - Type I transmembrane glycoprotein, 190 kDa, organised in trimers Class I fusion protein S1 sub-unit S2 sub-unit Responsible for attachment to ACE2 cellular receptor Responsible for fusion steps Signal Peptide Fusion Peptide TM

- The Spike protein is Spike responsible for entry steps of SARS-CoV jAn,c,eõmnt Sis a crucial structuraleprotein of SARS-CoV

'Endocytosla Search for cellular partners that interact with Spike using Yeast-two-Hybrid Screening Endofome ac1ol11crtMn ActivationolC.ttqoinL (Y2H) ~.~C9j~ :....r....... ..a..z. ..,..,.R. ........ .......,..

Cllvape/ActlvNlon of Spike, + D' #
Fudon ~ Annex 3 p4 ~ ~; ~ ;

Identification of cellular partners of S by Y2H
SPIKE
Cytoplasmic tail of S
- Composed o139 amino acids - Exposed to cytoqasm during maturation of S
- LocalisedinsldetheviralparticleaHerbudding S1 sub-unit - Exposed to the cytosd just atter fusion n .._ .~ S2 sub-unit - , . -~
%
Transmembrane Domain Cytoplasmic Tail ~

1216 125 rRl , . , . -. . ... ._..-,õ~~..,_ _. ~ . - .
N LG{'Yti.,t. C;,C ~.iit~t~(J~1J~7~ ,~t~r LEQt.~SLFVLKG'~KU {YT C
Cytoplasmic Tail Sequence 9 Potentially interacts with cellular partners during many steps of virus life cycle > Chosen as bait for Y2H screening - Screening of a human placenta cDNA library DI #

Annex 3 p5 Ezrin interacts with Spike : Spike-ezrin interaction was found with the highest frequency by Y2H (82 clones out of 147 millions tested) Poly-Pro ,296 J 474 585 ;io- Ezrin is known to link the actin N .. - = ~ = = = =, , c cytoskeleton with the plasma membrane Ezrin Ezrin belongs to the Ezrin/Radixin/Moesin (ERM) family of proteins :- Ezrin is implicated in: cell morphogenesis, cell mobility, cell survival, cell adherence and signal transduction.

'** Hypothesis : ezrin has a role in regulating SARS-CoV infection and may prove valuable target for anti-viral therapy DI #
Annex 3 p6 The Spike-ezrin interaction is confirmed in vitro by GST-PuII Down co-precipitation DI #
Annex 3 p7 Crude GST-S Cterm Cell GST- ~-~
Lyeate Beads FERM

Ezrin -80 kDa-~1000 .....,. ~.....w,r-, Crude GST-S Cterm Cell -Ab +Ab Lyeate GST
It Ezrin -80 kDa wow -Ab: Rabbit serum that recognizes the C-terminai domain of Spike The GST-S cterm fusion protein co-precipitates ezrin from HeLa and Vero-E6 cell lysates Ezrin is relocalized to SARS-CoV budding compartment and where S acumulates Confocal immunofluorescence microscopy experiemnt on SARS-CoV infected cells m ..,> õ s_.f....,._,...".,.r......a,,.,.
Colocalization of Spike and Ergic53/Golgi-58K
~
.=
Spike accumulates at the ER/Golgi intermediate compartment (ERGIC) which is the budding site .. ,,. o.. . . ==DI#..
..
ion Annex 3 p8 In non-infected cells, ezrin has a sub-cortical localization Ezfine .
, . , ,... , _ .,. ... . ,_ In infected cells, ezrin is mobilized to the sites where Spike accumulates and where viral budding occurs .

Lentiviral particles pseudotyped with Spike (SARSpp) as a tool for the study of early stages of SARS-CoV life cycle HIV'structural skeleton' containing a defective genome enabling only one round infection Pseudotyping: HIV envelope protein replaced by another envelope protein of a heterologous virus The heterologous envelope protein determines the entry SARS-CoV HIV mechanism of the particle Spike 'structural Skeleton' ~ Reporter gene (luciferase): quantification of transduction by pseudotyped particles DI #
Annex 3 p9 A decrease in intracellular ezrin levels dramatically increases entry of SARS-Spike pseudotyped particles a Effects of siRNA knock down of earin on transdcution of pseudotyped lentivirus particles 14.00 ---------------=--------------"--=-=-----.-_-...-'----=--------..
12.00 ....................... .....-...._---__........-..----------...
C
10.00 b HeLa-FS/SARSpp ____________________ __......._...............___....._..
Non-p Ts ge0ng E2rin y 9.00 ....................... .......... ............................. aIRNA
sIRNA
u Euln _ --.........___-__---....-..-_________... -6.00 ---.5060.
apkDS - ...__.. , -_______-_-......----_-____..------- ------ : ._.__- ...... . -_T_,_~_.. .
0.00 1t1 ' 1JI Envpp SARSpp VSVGp-p V
SVGpp HlVpp HA
pp ~
HeLa FS HeLa FS HeLa FS HeLa FS HeLa VA HeLa p4 HunJ
I1Non-Targetmy siRNA fiEtrin siRPIA

DI #
Annex 3 plO

Whereas a decrease in ezrin expression levels enhances entry of SARS-Spike pseudotyped particles, a decrease in radixin expression levels restricts entry c. Effects of siRNA knock down of ezrin and/or radixin on the transduction by SARS-Spike pseudotyped particles Non- Ezrin +
d. Targeting Ezrin Radixin Radixin 2000 cco .........................................7 4Y......................................... eIRNA eIRNA sIRNA sIRNA
Ezrin 7 t -80 kDa '"IMMw ~seu,cco --.._........_..._.-......-.-_ ...... : ................. ......
......... ..... ..............._.._ . , . , . . .
Non- Ezrin +
i.oo,.cco ............................. ...........
.................................................. ..... Targeting Ezrin Radixin Radixin > 2.9x siRNA siRNA siRNA siRNA
Radixin yY. seo.eco.. -.90 kDa Opmr ... v.w,.....r .

i -2.6x U
Nontargeting Ezrln Radixln Ezrin+Radicin siRNA siRNA siRNA siRNA

DI #
Annex 3 pl 1 Results on SARS coronavirus Spike interaction with ERM proteins The cytosolic tail of SARS CoV Spike glycoprotein interacts with Ezrin N-terminal domain We adopted a yeast-two-hybrid screening strategy to identify cellular proteins which interact with the cytosolic carboxy-terminal tail (CT) of SARS-Spike glycoprotein (aa 1216-1255). The screening of a human placenta random-primed cDNA library was performed by Hybrigenics company (Hybrigenics S.A., Paris, France). 233 clones came out from 147 millions of interactions tested. Sequencing of positive prey clones revealed that 35% of the clones (82/233 clones) correspond to human ezrin cDNA
fragments.
Spike CT domain / ezrin protein interaction was classified with a very high confidence score (Predicted Biological Score, PBS=A).
To determine which region of ezrin protein bound SARS-Spike CT domain, we defined the common nucleotidic sequence shared by all 82 ezrin encoding cDNAs. We identified a common sequence of 264 base pairs, encoding for a region of 88 amino-acids in the N-terminal part of ezrin protein. This region extends from amino-acids 6 to 93 and corresponds to subdomain Fl of the FERM domain. We called this region the ezrin Fl/Spike-binding domain (ezrin F1/SBD). Interestingly, 3 clones which correspond to radixin, another ERM protein, came out of the screening with a lower score than ezrin (PBS=B).
To confirm the interaction between SARS-Spike CT and ezrin F1/SBD, we performed GST pull-down assays. First, a GST-Spike CT fusion protein was tested for its capacity of binding to ezrin protein. Briefly, GST-Spike CT protein bound on gluthatione-sepharose beads was incubated with cell extracts from human epithelial HeLa cells or green monkey epithelial VeroE6 cells. In parallel gluthatione-sepharose beads alone or bound to GST were also incubated with cells extracts. Only gluthatione-sepharose beads bound to GST-Spike CT protein was able to pull down ezrin protein from cell extracts in a concentration dependant manner. Furthermore incubation in presence of a rabbit serum against Spike carboxy-terminal domain efficiently decreased ezrin binding to Spike CT. Moreover, another protein, integrin alpha5, also identified as a Spike CT
interacting protein in our yeast-two-hybrid screening (12/233 clones, PBS=A) was very inefficiently pulled down by GST-Spike CT. These results strongly suggest that Spike CT
and ezrin interact with a high level of specificity.

Ezrin is recruited to S-enriched sites in SARS-CoV infected cells In normal cells, inactivated ezrin is present within the cytosol and activated form is associated to cortical areas where it interacts with both filamentous actin and membrane receptors. We have shown that ezrin is efficiently recruited to the ERGIC-Golgi apparatus region in VeroE6 infected cells where it colocalises with SARS-S-rich sites.
This subcellular region is the site of SARS-S maturation as well as the site of SARS-CoV
assembly and budding. This results suggests a role of ezrin during the assembly/budding steps of SARS-CoV.

Ezrin restricts SARS CoV entry into permissive cells In order to investigate the role of ezrin protein in SARS-CoV infection, we have set up an anti-ezrin siRNA strategy which can shut down ezrin expression up to 90% in human cell lines. Interestingly, we have demonstrated that ezrin shut down lead to a strong enhancement of SARS-CoV pseudotype viruses entry into permissive cells (5 to times depending on experiments), suggesting that ezrin is a restricting factor of SARS
CoV infection.

Ezrin and Radixin have antagonistic effects on SARS CoV entry On the other hand, the shut down of the radixin protein (which belongs to the same ERM
protein family than ezrin, and which has also been identified by the Y2H
screen with a B
score) inhibits the infection of cells by SARS-CoV pseudotype viruses with a factor of -2.5. Moreover, simultaneous shut down of both ezrin and radixin ERM proteins leads to increase of infection by a factor -3. Altogether, these results suggest a regulatory role of ERM proteins on early stages of SARS-CoV infection mediated by the specific interaction with SARS-S CT domain and an antagonist effect of both ezrin and radixin proteins.

Yeast-2-Hybrid Screening Results (Hybrigenics) Bait Tested Positives A score B score interactions clones MPP5 = PALS1 S Ctail 147x106 233 Ezrin Quiescin Q6 (PDZ-containing Integ(n a5 S protease PRSS25 protein) ;..
E-cadherin Radixin Laminin a2 M Ctail 152x106 62 DIP NR2C2 Links,~
tangerin Membrane Receptors E Ctail 140x106 146 PaIs1/MPP5 MAZ (myc assoc. Cell pOlat"IZ8tI0I1 ZF) RAS A1 LIM-like protein 2G
RPN2 (ER N Sl9nal' C1 s C I
oligotransf.) DI#
Annex 4 p 1 OBJECTIVE
s. .
= To study the role of host cell factors which may specifically interact with the SARS-E envelope protein = To study how these cellular factors may regulate the SARS-CoV infection DI #
Annex 4 p2 PROTEINS O F AGUK FAMILY

= Newly-recognized class of scaffolding proteins that recruit signaling molecules into localized multimolecular complexes DI #
= Posses distinctive domain structure including: Annex 4 p3 = One or three copies of PDZ clornaiii FOUR different subfamilies:
~ AnSH3dornain A guanylate kinase (GUK) domain = Dig-like N1AGUKs ~ A HOOK domaln, located be;twee Z4-1 like SH3 and GUK cloinains, which binds the h I.
AC~ UKs cytoskeletal protein banct 4.1 and its = ~~'i-lll~e I'IAC.iUKs 1 __ ortholoRs. = Lin-2lil:e ~ CaM kinase and calmoclulin-bi dina MAGUKs do.mains (CaMK) " Lin-7 bindino or Veli-bindin4 Llomain Dimitratos et al., 1999, BioEssays. 21: 912-921 PROTEINS = MAGUK FAMILY

MAGUKs h7ammai Orosophila ~lt' - PSD-95 ~- r,- PSD-93 t y~ D9 A& SAP-97 ~1e1 tw: I~~-,; p CASK Carnfluk ~
ZO-2 Tan~ou ZO-3 Annex 4 p4 PALS
~ Stardust p55-(1-7) Alb MAG1-I1 -81 00:+ .~~~b "'"'. ~. Cnrmn it ~
w== . -- CaJi-subunit.(1-4) Ca'%-subunit PDZ SH3 GK L27 CaMK %YW CARD

Funke et a1., 2005, Ann Rev Biochem. 74: 219-245 Experi _ Yeast Two Hybrid Screening - Hybrigenics Identification of clones coding for 3 different PDZ domain-containing proteins:

HK4v1_pB27A-'131 (1 out of 28 clones) hMPP5; [gi1385701411reflNM_022474.21 Homo sapiens membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) (MPP5), mRNA]
HK4v'i_pB27A-122 hMPDZ; [giE45052301reflNM_003829.11 Homo sapiens multiple PDZ domain protein (MPDZ), mRNA] DI #
HK4v1___pB27A-158 Annex 4 p5 hGORASP2; [gi(298262931reflNM_015530.31 Homo sapiens golgi reassembly stacking protein 2, 55kDa (GORASP2), mRNA]

' _ x_ HK4v 1 _pB27A-131 hMPP5; [gi1385701411refINM_022474.21 Homo sapiens membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) (MPP5), mRNA]
KTGIDHPMFDTEEGIVLDRPHYAVKILEIEDLI=SSLKHIQHTL VDSQSQEDISLLLQLV
L27N domain QNEDi QTAFKIHAAITVHMNDAPP:"-;t; '',.: "{ T ; t7':'~t~'.1 xt L27C domain LPITDERVYESVGQYGGKTVKIVRiEEARDIPLG
ATVRNEMDSViiSRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMH
PDZ domain QEDPKVWVQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLW
SH3 domain CAKKNKKKRKKVLYNANKNDDYDNEEiLTYEEMSLYHQPANR':''-*:
DI # GuK domain t ,:~E_=..~: :I :!_R:'.: .'~;:;:~~ti; .'~ ,=a ~'; ,~ Annex 4 p6 ODEL OF INTERACTIO PALSI D
N_ _M'..
P. R . PARTNERS, . tu . . . . . . . t.. ~5~_ Extracellular DI #

fAAGUK recrui[mEnt Cytoplasm Annex 4 p7 {IvIRE) domain iRoh et al., 2002. J Cdl Bid. CRUMB (QosophHa) IRoh et al., 2002. J
157:161-172 - Results-Fig 51 Cdl Bial. 157: 161=1721 and human Protein associated ormdogue. CRBI lconysts dtarger extracellufar domain) IMakarOva at al., 2003.
with tight junction Gene. 302: 21-291 (PATJ) Human orthologue, CRB3 (oa,ssla = A 200kDa protein d' ernaNer extracMdar danain) iMakarova M
- Pandogue d nwMiple at., 2003. Gene. 302: 21-281 PDZ protefn (MUPP1) and CRB3 has a consened intracellular domain athaogue of Drosophtla, IMakarova N alõ 2003. Gene. 302: 21-29) Cisc last (Olt) IRah et ~
al., 2002. J Cdl Bid.
157:161-1721. ...i",i;rin F:"i+.~-;i~ ;-='-+a.f.
Primary tunceonc Is to tie Rhe apical membrane to eght jiaKtions domaYn (Makarova et M., 2003. Gene. 302 21-291 ~ L27N domain Protein PALS1 PDZ domain binds to C-terminal of O L27C domain associated with human transmembrane protein caAed PDZ domain Lin-7 (PALS) CrumblCrumbl (CRBI)/Crumb3 (CRB3) Homologue - [Makarova et 21..2003. Gene. 302: 21-29; SH3 domain Stardust Roh et al., 2003. J Cell Sci.116: 2895-2906;
Tight Junction (Drosophila) Roh et al., 2002. J Cetl Biol. 157: 161-1721 GUK domain A 4.1B (HOOK) domain = D = =
sr~

,r L27N domain L27C domain PDZ domain motif : BAIT: SARS-CoV, C-terminal domain of _.=='~ T-- X-- V Envelope E protein (34-76) PDZ domain LTALRLCAYCCNIVNVSLVKPTVYVYSRVK
NLNSSEGVPDLLV

SH3 domain DLLV is very similar to the consensus PDZ
bindin motif GUK domain p551MPPS(PAL51) DI #
Annex 4 p8 ~.. D = = PALSI . DING Di .
3x ~~ ..._ ~~..
We have defined the common sequense shared by all 28 Pals1 cDNA clones as the minimal binding domain of Palsi to SARS CoV E protein C-terminal domain.

Clones HK4v1_pB27A-67 (shortest 5') and HK4v1_pB27A-47 (shortest 3') were used to define minimal binding domain.
Contig between clones HK4v1_pB27A-67 and HK4v1_pB27A47 ( nucleotide position 660-1113 in comparison to the full-lengh contig sequence of 28 Pais1 cDNA clones), 452bp CTAGAGCCCATTAAAGAAGAGAGAGTTTATGAAAGTGTTGGCCAGTATGGAAGAAAAACTGTAAAAATAGTTCGTAAAG

AAGAGGCTCGTGATATTCCGTTGGGTGCTACAGTTCATAAAGAAATGGACTCTGTCATCATTAGCCGGATAGTAAGAGG

GGCTGCTGCAGAGAAAAGTGGTCTGTTGCATGAAAGAGATGATGTTCTAAAGATTAATGGCGTTGAAAGTCGGGAGAA
AGATATCAATGAAGTTTTTGACTTGTTGTCTGATATGCATGGTACTTTGACTTTTGTCCTGATTCCCAGTCAACAGATC
AA
GCCGCCTCCTGCCAAGGAAACAGTAATCCATGTAAAAGCTCATTTTGACTATGACCCCTCAGATGACCCTTATGTTCCA

TGTCGAGAGTTAGGTCTGTCTTTTCAAAAAGGTGATATACTTCATGTGATCAGTCA DI #
Translation and protein domain identification Annex 4 p9 = Using ExPASy Proteomics tools, Transeq ~ Identification of protein domains using PROSITE, Database of protein domains, families and functional sites . . . ., ~ i: ~' _ 1 =' _:.:' ~ õ
. . ... . _ -_: . a .
LEPIKEERVYESVGQYGRKTVK'"~- r c _"'~, '' = TFL! =s.'~'QIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVIS

= As showed from the above results, using Clones HK4v1_pB27A-67 and HK4v1_pB27A-07, we have managed to define the minimal binding site, which consist of a:' and a truncated SH3 domain.
= Previous studies have reported that PALS1 PDZ domain is crucial for binding with cellular factors, such as Crumb 1(CRB1) and 3 (CRB3), via its PDZ domain motif T-F V.
Pals1 is part of a molecular complex crutial for the stability of tight junctions (Doyle et al., 1996.
Cell. 85: 1067-1076; Songyang et al., 1997. Science. 275: 73-77; Makarova et al., 2003. Gene. 302: 21-29;
Kantardzhieva et al., 2005. Invest Ophthalmol Vs Sci. 46: 2192-2201) Interacting domains Note: For a complete view on all data obtained from the Y2H screening, please refer to Annexes 1 (raw datas from Hybrigenics) SARS coronavirus Spike (S) protein C-terminal sequence:
S CT (1216-1255) :
CCMTSCCSCLKGACSCGSCCKFDEDDSEPVLKGVKLHYT
Cellular factors identified for S CT binding with A score by Y2H screening:

- Ezrin: hVIL2; [giJ216144981refINM_003379.31 Homo sapiens villin 2 (ezrin) (VIL2), mRNA]
- E-cadherin: hCDH1; [gi l14589887 1ref INM_004360.2 1 Homo sapiens cadherin 1, type 1, E-cadherin (epithelial) (CDH1), mRNA
- Integrin alpha 5: hITGA5; [gil562370281refINM_002205.21 Homo sapiens integrin, alpha 5(fibronectin receptor, alpha polypeptide) (ITGA5), mRNA

Ezrin interaction domain with S CT:
Ezrin (6-93: containing the Fl subdomain of ezrin FERM N-terminal domain):
NVRVTTMDAELEFAIQPNTTGKQLFDQWKTIGLREVWYFGLHYVDNKGFPTWLKLDK
KVSAQEVRKENPLQFKFRAKFYPEDVAEEL
E-cadherin interaction domain with S CT:
E-Cadherin preproprotein (5-72):
SRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFEDCTG
RQRTAYFSLD

Integrin alpha 5 interaction domain with S CT:
Integrin alpha 5 preprotein (24-334):
PLLPLLLLLLPPPPRVGGFNLDAEAPAVLSGPPGSFFGFSVEFYRPGTDGVSVLVGAPK
ANTSQPGVLQGGAVYLCPWGASPTQCTPIEFDSKGSRLLESSLSSSEGEEPVEYKSLQ
WFGATVRAHGSSILACAPLYSWRTEKEPLSDPVGTCYLSTDNFTRILEYAPCRSDFSW
AAGQGYCQGGFSAEFTKTGRWLGGPGSYFWQGQILSATQEQIAESYYPEYLINLVQG
QLQTRQASSIYDDSYLGYSVAVGEFSGDDTEDFVAGVPKGNLTYGYVTILNGSDIRSLY
NFSGEQMASYFGYAVAATD

SARS coronavirus Envelope (E) protein C-terminal sequence:
E CT (34-76):
LTALR LCAYC CNIVN VSLVK PTVYV YSRVK NLNSS EGVPD LLV

Cellular factors identified for E CT binding with A score by Y2H screening:
- PaIs1IMPP5 - RPN2 (ER N oligotransf.) Interacting domains Note: For a complete view on all data obtained from the Y2H screening, please refer to Annexes 1 (raw datas from Hybrigenics) SARS coronavirus Spike (S) protein C-terminal sequence:
S CT (1216-1255) :
CCMTSCCSCLKGACSCGSCCKFDEDDSEPVLKGVKLHYT
Cellular factors identified for S CT binding with A score by Y2H screening:

- Ezrin: hVIL2; [gil216144981refINM_003379.31 Homo sapiens villin 2 (ezrin) (VIL2), mRNA]
- E-cadherin: hCDH1; [gi l14589887 1ref iNM_004360.2 1 Homo sapiens cadherin 1, type 1, E-cadherin (epithelial) (CDH1), mRNA
- lntegrin alpha 5: hITGA5; [gil562370281refINM_002205.21 Homo sapiens integrin, alpha 5 (fibronectin receptor, alpha polypeptide) (ITGA5), mRNA

Ezrin interaction domain with S CT:
Ezrin (6-93: containing the Fl subdomain of ezrin FERM N-terminal domain):
NVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDK
KVSAQEVRKENPLQFKFRAKFYPEDVAEEL
E-cadherin interaction domain with S CT:
E-Cadherin preproprotein (5-72):
SRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFEDCTG
RQRTAYFSLD

Integrin alpha 5 interaction domain with S CT:
Integrin alpha 5 preprotein (24-334):
PLLPLLLLLLPPPPRVGGFNLDAEAPAVLSGPPGSFFGFSVEFYRPGTDGVSVLVGAPK
ANTSQPGVLQGGAVYLCPWGASPTQCTPIEFDSKGSRLLESSLSSSEGEEPVEYKSLQ
WFGATVRAHGSSILACAPLYSWRTEKEPLSDPVGTCYLSTDNFTRILEYAPCRSDFSW
AAGQGYCQGGFSAEFTKTGRWLGGPGSYFWQGQILSATQEQIAESYYPEYLINLVQG
QLQTRQASSIYDDSYLGYSVAVGEFSGDDTEDFVAGVPKGNLTYGYVTILNGSDIRSLY
NFSGEQMASYFGYAVAATD

SARS coronavirus Envelope (E) protein C-terminal sequence:
E CT (34-76):
LTALR LCAYC CNIVN VSLVK PTVYV YSRVK NLNSS EGVPD LLV

Cellular factors identified for E CT binding with A score by Y2H screening:
- PaIs1/MPP5 - RPN2 (ER N oligotransf.) PaIs1/MPP5 interaction domain with E CT:
Pals1/Mpp5 (234-383: containing the PDZ domain and part of the SH3 domain):
LEPIKEERVYESVGQYGRKTVKIVRKEEARDIPLGATVHKEMDSVIISRIVRGAAAEKSGL
LHERDDVLKINGVESREKDINEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFD
YDPSDDPYVPCRELGLSFQKGDILHVIS

-. . ,.. -..-.r. ,. . -..... . - i 1 i i I
. ..,. ~ ...,r.. . _ a.- ... ... . . . -... . . ..
_ ._ . ..1.. . .. .. } ,~
PDZ-signaling SARS coronavirus Membrane (M) protein C-terminal sequence:
M CT (101-221):
LFART RSMWS FNPET NILLN VPLRG TIVTR PLMES ELVIG AVIIR GHLRM AGHSL
GRCDI KDLPK EITVA TSRTL SYYKL GASQR VGTDS GFAAY NRYRI GNYKL NTDHA
GSNDN IALLV Q

Cellular factors identified for M CT binding with A score by Y2H screening:

- Tangerin SPIN90/DIP interaction domain with M CT:
SPIN90/DIP (310-478):
MELVRRNTGLSHELCRVAIGIIVGHIQASVPASSPVMEQVLLSLVEGKDLSMALPSGQV
CHDQQRLEVIFADLARRKDDAQQRSWALYEDEGVIRCYLEELLHILTDADPEVCKKMC
KRNEFESVLALVAYYQMEHRASLRLLLLKCFGAMCSLDAAI ISTLVSSVLP

Page 1 sur 136 //)'ItRIGENIC'S: C'O:ITIDENTI.1 L

HK1(1-39)vs PLA_RP (Human Placenta Randoni Primed 3) Thu Jan 13 15:25:31 CET 2005 Nature: cDNA
Organism:Human Strain:No Data Scree n=HK1v1 Bait Fusion;pB27 (LexA, C-terminal fusion) Organ:Placenta Cell Type:No Data Cult Cell Strain: No Data Sequences Analyzed: 398 Contig Number Contig Member(s) Contig Ali nment Contig Sequence Contig8298497 2 Alignment Sequence lContig829849911 2 Alignment IF-Scquei IF-Contig8298501 2 Alignment Sequence Contig8298503 2 Aligninent IF-Sequence Contig8298505 2 Alignment Sequcnce 1Contig8298507 2 Aligninent Sequence Contig8298510 I Alitnnient Sequence Contig8298512 2 Aligonincnt IF-Seqticji 1Contig8298513 1 Al ignment Sequencc Contig8298515 2 Alignment SCqUe11cC
Contig8298518 1 Alignment Szquence rContig8298519 2 11 Alignment Sequence JContig8298522 1 Alignment Sequence Contig8298524 3 Alignnie t Sequence Contig8298528 1 11 Alignment Sequence Contig8298529 I Alignnlent Sequence Contig8298532 1 11 Alignment Sequence Contig8298535 I Ali~nment IF-Sequence 1Contig8298538 I Alibninent Sequence Contig8298540 4 Al ignment Scquence Contig8298544 3 Alignincnt Scquence 1Contig8298548 2 nlignnient Sequence Page 2 sur 136 Contig8298549 1 54 11 Aliennlent Se.quencc Contig8298584 2 Alibnment Sequence Contig82985$7 I Alignment Sequence ~
Contig8298589 2 Aligiunent Sequence 1Contig8298592 I Aligmnent Sequence Contig8298594 3 Alienment Sequence Contig8298598 1 Align-ment Sequence Contig8298600 2 Alignment Seduence Contig8298604 1 Alignment Sequence Contig8298606 2 Alignnieit Sec uence Contig8298608 1 Alignment Sequence Contig8298610 2 Alip-nment Sequence Contig8298613 I Alignment Sequenee Contig8298615 I Aliunn~ent Sequence Contig8298616 1 Aligiunent Sequence Contig8298618 II Alignment Sequence Contig8298620 1 Alignment (eauence Contig8298622 22 Ali mnent Sequence Contig8298638 17 ~ Alignment Sequence 1Contig8298647 2 Aligninent Sequence Contig8298650 6 Alignment Sequence Contig8298655 2 Alignment Sequence Contig8298657 1 A1ignment Sequence Contig8298659 5 Aljanment Se uence Contig8298663 1 Ali nnient Sequence Contig8298665 3 Alignment IF- Sequence Contig8298669 I Alig_nnieit 11 Sequence Contig8298672 8 Ali tg 7 ent Sequence Contig8298678 1 Ali nment IF_ Sequence Contig8298679 3 Ali iunent Sequence 1Contig8298683 1 Alignment Sequence Contig8298685 3 Alignment Sequence 1Contig8298686 1 Alignment Sequence Contig8298688 1 Alienment S~ce uence Contig8298691 1 Alignment Se uence Contig8298693 F-- 1 Ali nment Sequence Contig8298694 1 AliQ~ment Sequence Contig8298695 1 Ali nment Sequence Contig8298697 I Alionrnent Sequence Contig8298698 1 Alignment Seq_.uence Page 3 sur 136 Contig8298700 I 1 Alignment ll Sequcncc , Contig8298702 I Alignment Sequence Contig8298704 I Alignment Sequence Contig8298706 I Alignment Sequence Contig8298708 1 Alignment Se_quence Contig8298710 I Alignment Sequence Contig8298712 1 Alignnent Sequence Contig8298713 1 Alignment Sequence Contig8298715 1 Align7ITent Sequence Contig8298717 1 Alignment Sequence Contig8298720 1 Alignment Sequence Contig8298722 1 Alignniet Sequence Contig8298724 1 Afignment Sec uence Contig8298726 I Alignment Sequence Contig8298728 1 Alignment Sequence Contig8298730 1 Alignment Sequence Contig8298732 1 ~ Alignment Sequence Contig8298735 3 Ali ~nment Sequence Contig8298736 12 Ali gnment Sequence Contig8298751 3 Ali ninent Sequepce Contig8298753 2 Ali nn~ent Sequence Contig8298755 11 F Abgnment Se , uence Contig8298762 2 Ali nment Sequence Contig8298764 2 Alignment Se qt ience Contig8298766 133 Alienment Sequence Contig8298856 2 Alionment Sequence Contig8298858 1 Aliennient Sequence 1Contig8298859 1 Alignment Sequence Contig8298862 1 Alienment Sequence Contig8298865 1 Ali ig lment Sequence Contig82988b7 1 Lkli t~ent Sequence Contig8298868 1 Alignment Sequence Contig82988b9 1 Alignment Sequence IContig8298-8-7--111 1 Alignment $equence Contig8298872 1 Alignment Seguence Contig8298875 2 1 AliQnment Se uence Contig8298497 Alignment HK1 laA-197_5p TTTTTATTCTCACACCGCCTGTTAAAGTGGGG
HK1 laA-197_3p CTCTCCTTTCAACGTGTATCCTGGTGAACAATAATACTCACACCGGGAGTTAAAGTAGGC

Page 4 sur 136 Contig8298497 CTCTCCTTTCAACGTGTATCCTGGTGAACAATAATACTCACACCGCCAGTTAAAGTAGGC
HK1 laA-197_5p GCGGTGTTCACACTTAAACCCTCCCCTTCTTGGCTCGCACAGGGTGGGACATCGCTTTTG
HK1 laA-197_3p ACCATCTACACACTTAAACCCTCCATTTGCTGGCATGGCAAGGGTAGGACATCGCTTTTG

Contig8298497 ACCATCTACACACTTAAACCCTCCACTTCCTGGCACGCAAAGGGTAGGACATCGCTTTTG
HK1 laA-197_5p TTTCGCAGATGACCTTGTCTGACCATCCTTTTTTTGATTGGCAGATCAGTAGGGAAGAGC
HK1 laA-197_3p TTT-GCAGATGACCTTGTCAGACCATCGTTTGTTTGACTGGCAGATCAGTAGGGAAGAGC

ContigB298497 TTTCGCAGATGACCTTGTCAGACCATCCTTTGTTTGACTGGCAGATCAGTAGGGAAGAGC
HK1 1aA-197_5p CATGCAGCTTGTAGCCCTTTTGGCAGCGAATGTTGCACCTGGTTCCCAGGGCTGTTTTGT
HK1 laA-197_3p CATGCAGCTCGTAGCCCTTCTGGCAGCGAATGTCGCACCTGGTTCCCAGGGCTGTTTTGT

Contig8298497 CATGCAGCTCGTAGCCCTTCTGGCAGCGAATGTCGCACCTGGTTCCCAGGGCTGTTTTGT
HK1 1aA-197_5p AGTATTTTCCTTTAGGGGCCGTGCAGGAGACATCCCCATAATTCACCTTGATGGGGGAGC
HK1 laA-197_3p AGTATCCTCCTTGAGGGGCCCTGCAGTACACATCCCCATACTTCACCTTGATGGGGGAGC

Contig8298497 AGTATCCTCCTTGAGGGGCCCTGCAGGACACATCCCCATAATTCACCTTGATGGGGGAGC
HK1 1aA-197_5p ACCACGGGGTATCTTTATATTTAGGGTGTGAATACCCGACTTCATTGTCTTCTAGTGGTG
HK1 laA-197_3p ACCACGGGGTATCTTTATATCTAGGGTGTGAATACCCGACTTCATCGTCTTCTAGTGGTG

Contig8298497 ACCACGGGGTATCTTTATATCTAGGGTGTGAATACCCGACTTCATCGTCTTCTAGTGGTG
HK1 laA-197_5p AGTTTCCCGATCCTGGGAAGATGTGGTTGGGGGGGAGGGGCAGCAGCAGCAGCAGCAGCA
HK1 1aA-197_3p AGTCTCCCGATCCTGGGAAGCTGCGGCTGGGCGGGACGCGCAGCAGCAGCAGCAGCAGCA

Contig8298497 AGTCTCCCGATCCTGGGAAGATGCGGCTGGGCGGGACGCGCAGCAGCAGCAGCAGCAGCA
HK1 laA-197_5p AAGGCGGCAGCAGCAGCAGCAGCGCGGGCCGATATGCGGGGCTCCCCATGCCGAGCGGGC
HK1 laA-197_3p GAGGCGGCAGCAGCAGCAGCC

Contig8298497 AAGGCGGCAGCAGCAGCAGCAGCGCGGGCCGATATGCGGGGCTCCCCATGCCGAGCGGGC
HK1 1aA-197_5p GNTTAGNTTGCCTTGGCAGCGCAGCGGGGTTCCCTTCAAAAAAACAAAGCACACA

Contig8298497 GNTTAGNTTGCCTTGGCAGCGCAGCGGGGTTCCCTTCAAAAAAACAAAGCACACA
Contig8298497 Consensus sequence >Contig8298497 535 nt CTCTCCTTTCAACGTGTATCCTGGTGAACAATAATACTCACACCGCCAGTTAAAGTAGGCACCATCTACACACTTAAAC
C
CTCCACTTCCTGGCACGCAAAGGGTAGGACATCGCTTTTGTTTCGCAGATGACCTTGTCAGACCATCCTTTGTTTGACT
G
GCAGATCAGTAGGGAAGAGCCATGCAGCTCGTAGCCCTTCTGGCAGCGAATGTCGCACCTGGTTCCCAGGGCTGTTTTG
T
AGTATCCTCCTTGAGGGGCCCTGCAGGACACATCCCCATAATTCACCTTGATGGGGGAGCACCACGGGGTATCTTTATA
T
CTAGGGTGTGAATACCCGACTTCATCGTCTTCTAGTGGTGAGTCTCCCGATCCTGGGAAGATGCGGCTGGGCGGGACGC
G
CAGCAGCAGCAGCAGCAGCAAAGGCGGCAGCAGCAGCAGCAGCGCGGGCCGATATGCGGGGCTCCCCATGCCGAGCGGG
C

Page 5 sur 136 GNTTAGNTTGCCTTGGCAGCGCAGCGGGGTTCCCTTCAAAAAAACAAAGCACACA

back to table Contig8298499 Alignment HK1 laA-30_3p CTGCTGCACGCTGGAACCATGTGTGGGTCGGCACCGAGACTGGGATCTTGAAAGGGGTAA
HK1 1aA-30_5p CTGCTGCACGCTGGAACCATGTGTGGGTCGGCACCGAGACTGGGATCTTGAAAGGGGTAA

Contig8298499 CTGCTGCACGCTGGAACCATGTGTGGGTCGGCACCGAGACTGGGATCTTGAAAGGGGTAA
HK1 laA-30_3p ATCTTCAGCGAAAACAGGCGGCGAACTTCACGGCCGGAGGACAGCCGCGGCGCGAGGAGG
HK1 laA-30_5p ATCTTCAGCGAAAACAGGCGGCGAACTTCACGGCCGGAGGACAGCCGCGGCGCGAGGAGG

Contig8298499 ATCTTCAGCGAAAACAGGCGGCGAACTTCACGGCCGGAGGACAGCCGCGGCGCGAGGAGG
HK1 laA-30_3p CAGTGAGCGCCCTGTGTTGGGGCACCGGCGGCGAGACCCAGATGCTGGTGGGCTGCGCGG
HK1 SaA-30_5p CAGTGAGCGCCCTGTGTTGGGGCACCGGCGGCGAGACCCAGATGCTGGTGGGCTGCGCGG

Contig8298499 CAGTGAGCGCCCTGTGTTGGGGCACCGGCGGCGAGACCCAGATGCTGGTGGGCTGCGCGG
HK1 laA-30_3p ACAGGACGGTGAAGCACTTCAGCACCGAGGATGGCATATTCCAGGGTCAGAGACACTGCC
HK1 laA-30_5p ACAGGACGGTGAAGCACTTCAGCACCGAGGATGGCATATTCCAGGGTCAGAGACACTGCC

Contig8298499 ACAGGACGGTGAAGCACTTCAGCACCGAGGATGGCATATTCCAGGGTCAGAGACACTGCC
HK1 laA-30_3p CGGGCGGGGAGGGCATGTTCCGTGGCCTCGCCCAGGCCGACGGCACCCTCATCACATGTG
HK1 laA-30_5p CGGGCGGGGAGGGCATGTTCCGTGGCCTCGCCCAGGCCGACGGCACCCTCATCACATGTG

Contig8298499 CGGGCGGGGAGGGCATGTTCCGTGGCCTCGCCCAGGCCGACGGCACCCTCATCACATGTG
HK1 laA-30--3p TGGATTCTGGGATTCTCAGAGTCTGGCATGACAAGGACAAGGACACATCCTCTGACCCAC
HK1 laA-30_5p TGGATTCTGGGATTCTCAGAGTCTGGCATGACAAGGACAAGGACACATCCTTTGACCCAC

Contig8298499 TGGATTCTGGGATTCTCAGAGTCTGGCATGACAAGGACAAGGACACATCCTCTGACCCAC
HK1 laA-30_3p TCCTGGAACTGAGAGTGGGCCCTGGG
HK1 laA-30_5p TCCTGGAACTGAGAGTGGGCCCTGGGGTGTGTAGGATGCGCCAAGACCCAGC

Contig8298499 TCCTGGPACTGAGAGTGGGCCCTGGGGTGTGTAGGATGCGCCAAGACCCAGC
Contig8298499 Consensus sequence >Contig8298499 412 nt CTGCTGCACGCTGGAACCATGTGTGGGTCGGCACCGAGACTGGGATCTTGAAAGGGGTAAATCTTCAGCGAAAACAGGC
G
GCGAACTTCACGGCCGGAGGACAGCCGCGGCGCGAGGAGGCAGTGAGCGCCCTGTGTTGGGGCACCGGCGGCGAGACCC
A
GATGCTGGTGGGCTGCGCGGACAGGACGGTGAAGCACTTCAGCACCGAGGATGGCATATTCCAGGGTCAGAGACACTGC
C
CGGGCGGGGAGGGCATGTTCCGTGGCCTCGCCCAGGCCGACGGCACCCTCATCACATGTGTGGATTCTGGGATTCTCAG
A
GTCTGGCATGACAAGGACAAGGACACATCCTCTGACCCACTCCTGGAACTGAGAGTGGGCCCTGGGGTGTGTAGGATGC
G
CCAAGACCCAGC

Page 6 sur 136 Liback to table Contig8298501 Alignment HK1 laA-80__3p CTTCCGCTGCGGCTGCGGCTGCTGCTGCTGCTCTGGGCGGCCGCCGCCTCCGCCCAGGGC
HK1 laA-80_5p CTTCCGCTGCGGCTGCGGCTGCTGCTGCTGCTCTGGGCGGCCGCCGCCTCCGCCCAGGGC

Contig8298501 CTTCCGCTGCGGCTGCGGCTGCTGCTGCTGCTCTGGGCGGCCGCCGCCTCCGCCCAGGGC
HK1 laA-80_3p CACCTAAGGAGCGGACCCCGCATCTTCGCCGTCTGGAAAGGCCATGTAGGGCAGGACCGG
HK1 laA-80_5p CACCTAAGGAGCGGACCCCGCATCTTCGCCGTCTGGAAAGGCCATGTAGGGCAGGACCGG

Contig829a501 CACCTAAGGAGCGGACCCCGCATCTTCGCCGTCTGGAAAGGCCATGTAGGGCAGGACCGG
HK1 laA-80_3p GTGGACTTTGGCCAGACTGAGCCGCACACGGTGCTTTTCCACGAGCCAGGCAGCTCCTCT
HK1 laA-80_5p GTGGACTTTGGCCAGACTGAGCCGCACACGGTGCTTTTCCACGAGCCAGGCAGCTCCTCT

Contig8298501 GTGGACTTTGGCCAGACTGAGCCGCACACGGTGCTTTTCCACGAGCCAGGCAGCTCCTCT
HK1 1aA-80-_3p GTGTGGGTGGGAGGACGTGGCAAGGTCTACCTCTTTGACTTCCCCGAGGGCAAGAACGCA
HK1 1aA-80_5p GTGTGGGTGGGAGGACGTGGCAAGGTCTACCTCTTTGACTTCCCCGAGGGCAAGAACGCA

Contig8298501 GTGTGGGTGGGAGGACGTGGCAAGGTCTACCTCTTTGACTTCCCCGAGGGCAAGAACGCA
HK1 laA-80_3p TCTGTGCGCACGGTGAATATCGG
HK1 laA-80__5p TCTGTGCGCACGGTGAATATCGG

Contig8298501 TCTGTGCGCACGGTGAATATCGG

Contig8298501 Consensus sequence >Contig8298501 263 nt CTTCCGCTGCGGCTGCGGCTGCTGCTGCTGCTCTGGGCGGCCGCCGCCTCCGCCCAGGGCCACCTAAGGAGCGGACCCC
G
CATCTTCGCCGTCTGGAAAGGCCATGTAGGGCAGGACCGGGTGGACTTTGGCCAGACTGAGCCGCACACGGTGCTTTTC
C
ACGAGCCAGGCAGCTCCTCTGTGTGGGTGGGAGGACGTGGCAAGGTCTACCTCTTTGACTTCCCCGAGGGCAAGAACGC
A
TCTGTGCGCACGGTGAATATCGG

back to table Contig8298503 Alignment HK1 laA-194_5p CACAAGTGTGAAGCCTGGAACCCGGCGGGTGCCGCTGTGTAAGAAAGAAACTAACCCTCT
HK1 1aA-194_3p TGTGTAGGAAAGAAGCTAAAGCACT

Contig8298503 CACAAGTGTGAAGCCTGGAACCCGGCGGGTGCCGCTGTGTAAGAAAGAAACTAAACCACT
HK1 laA-194_Sp TCCAGAGCCTGTCCGGAGCTAATTAGGTTCGGAAGACTTCTCGACCATGGAGCGCGCGTC
HK1 laA-194,_3p TCCAGAGCCTGTCCGGAGCTCAG-AGGTTCGGAAGACTTATCGACCATGGAGCGCGCGTC

Contig8298503 TCCAGAGCCTGTCCGGAGCTAAGTAGGTTCGGAAGACTTATCGACCATGGAGCGCGCGTC

Page 7 sur 136 HK1 laA-194_5p CTGTTTGTTGCTGCTGCTGCTGCCGCTGGTGCCCTTCTCTGCGACCCCGCCAGAACCTTG
HK1 laA-194_3p CTGCTTGTTGCTGCTGCTGCTGCCGCTGGTGCACGTCTCTGCGACCACGCCAGAACCTTG

Contig8298503 CTGCTTGTTGCTGCTGCTGCTGCCGCTGGTGCACGTCTCTGCGACCACGCCAGAACCTTG
HK1 laA-194_5p TGAGCTGGACGATGAATATTTCCGCTGCGTCTGCAACTTCTCCGAACCTCACCCCGACTG
HK1 1aA-194_3p TGAGCTGGACGATGAAGATTTCCGCTGCGTCTGCAACTTCTCCGAACCTCAGCCCGACTG

Contig8298503 TGAGCTGGACGATGAAGATTTCCGCTGCGTCTGCAACTTCTCCGAACCTCACCCCGACTG
HK1 laA-194_5p GTCCGAAGCCTTCCAGTGTGTGTCTGCAGTAGAGGTGGAGATCCATGCCGGCGGTCTCAA
HK1 laA-194_3p GTCCGAAGCCTTCCAGTGTGTGTCTGCAGTAGAGGTGGAGATCCATGCCGGCGGTCTCAA

Contig8298503 GTCCGAAGCCTTCCAGTGTGTGTCTGCAGTAGAGGTGGAGATCCATGCCGGCGGTCTCAA
HK1 1aA-194_5p CCTAGAGCCTTTTCTAAAGCGCGTCGATGCGGACGCCGACCCGCGGCATTATGCTGACAC
HK1 1aA-194_3p CCTAGAGCCGTTTCTAAAGCGCGTCGATGCGGACGCCGACCCGCGGCAGTATGCTGACAC

Contig8298503 CCTAGAGCCGTTTCTAAAGCGCGTCGATGCGGACGCCGACCCGCGGCAGTATGCTGACAC
HK1 laA-194_5p GGTCGAGGCTCTCCGCGTGCGGCGGCTCAAAGTGGGACCCTACAATTTTCCTGCTCAGCT
HK1 laA-194_3p CGTCAAGGCTCTCCGCGTGCGGCGGCTCACAGTGGGAGCCGCACAGGTTCCTGCTCAGCT

Contig8298503 GGTCAAGGCTCTCCGCGTGCGGCGGCTCAAAGTGGGACCCGAAAAGGTTCCTGCTCAGCT
HK1 1aA-194_5p ACTGGTAGGCGCCGTGCGTGTGCTANCCTACTCCCGCGCTTCCGCG
HK1 laA-194_3p ACTGGTAGGCGCCCTGCGTGTGCTAGCGTACTCCCGCC

Contig8298503 ACTGGTAGGCGCCCTGCGTGTGCTAGCCTACTCCCGCCCTTCCGCG
Contig8298503 Consensus sequence >Contig8298503 466 nt CACAAGTGTGAAGCCTGGAACCCGGCGGGTGCCGCTGTGTAAGAAAGAAACTAAACCACTTCCAGAGCCTGTCCGGAGC
T
AAGTAGGTTCGGAAGACTTATCGACCATGGAGCGCGCGTCCTGCTTGTTGCTGCTGCTGCTGCCGCTGGTGCACGTCTC
T
GCGACCACGCCAGAACCTTGTGAGCTGGACGATGAAGATTTCCGCTGCGTCTGCAACTTCTCCGAACCTCACCCCGACT
G
GTCCGAAGCCTTCCAGTGTGTGTCTGCAGTAGAGGTGGAGATCCATGCCGGCGGTCTCAACCTAGAGCCGTTTCTAAAG
C
GCGTCGATGCGGACGCCGACCCGCGGCAGTATGCTGACACGGTCAAGGCTCTCCGCGTGCGGCGGCTCAAAGTGGGACC
C
GAAAAGGTTCCTGCTCAGCTACTGGTAGGCGCCCTGCGTGTGCTAGCCTACTCCCGCCCTTCCGCG
back to table Contig8298505 Alignment HK1 1aA-119_3p CACACATCCATCTTCCTCAGGGGGCCACCAGGGTCCTCACCGCAACCTGCACCTTTGCGC

Contig8298505 CACACATCCATCTTCCTCAGGGGGCCACCAGGGTCCTCACCGCAACCTGCACCTTTGCGC
HK1 1aA-119_3p CTTCGAGATTGGGCTTTATGCCCTTGGCCTGCACAACTTTGTTTCTCCCAACTGGCTCTC

Page 8 sur 136 Contig8298505 CTTCGAGATTGGGCTTTATGCCCTTGGCCTGCACAACTTTGTTTCTCCCAACTGGCTCTC
HK1 laA-119_3p ACGTACTTATTCTTCCCACGTTTCCTGGATTACAGGCCAGGCCATGGAGATAGGCAGCGC

Contig8298505 ACGTACTTATTCTTCCCACGTTTCCTGGATTACAGGCCAGGCCATGGAGATAGGCAGCGC
HK1 laA-119_3p AGCCCTGACTATACTGGTAGAATGCTGGGATGGGCACCTGACACCCCCTGAGGTTGCATC

Contig8298505 AGCCCTGACTATACTGGTAGAATGCTGGGATGGGCACCTGACACCCCCTGAGGTTGCATC
HK1 laA-119_3p CCTGGCTGACAGGGCATCACGGGCAAGAGACTCCAATATGGTGAGGGCGGCAGCAGAGCT
HK1 laA-119_5p ATCACGGGCAAGAGACTCCAATATGGTGAGGGCGGCAGCAGAGCT

Contig8298505 CCTGGCTGACAGGGCATCACGGGCAAGAGACTCCAATATGGTGAGGGCGGCAGCAGAGCT
HK1 laA-119_3p GGCCCTGAGCTGCCTGCCTCACGCCCATGCATTGAACCCTAATGAGATCCAGCGGGCCCT
HK1 laA-119_5p GGCCCTGAGCTGCCTGCCTCACGCCCATGCATTGAACCCTAATGAGATCCAGCGGGCCCT

Contig8298505 GGCCCTGAGCTGCCTGCCTCACGCCCATGCATTGAACCCTAATGAGATCCAGCGGGCCCT
HK1 1aA-119_3p GGTGCAGTGCAAGGAACAGGACAACCTGATGTTGGAGAAGGCCTGCATGGCAGTGGAAGA
HK1 laA-119_5p GGTGCAGTGCAAGGAACAGGACAACCTGATGTTGGAGAAGGCCTGCATGGCAGTGGAAGA

Contig8298505 GGTGCAGTGCAAGGAACAGGACAACCTGATGTTGGAGAAGGCCTGCATGGCAGTGGAAGA
HK1 laA-119_3p GGCAGCTAAGGGT
HK1 laA-119_5p GGCAGCTAAGGGTGGGGGCGTGTACCCTGAAGTGTTGTTTGAGGTTGCTCACCAGTGGTT

Contig8298505 GGCAGCTAAGGGTGGGGGCGTGTACCCTGAAGTGTTGTTTGAGGTTGCTCACCAGTGGTT
HK1 laA-119_5p CTGGCTATATGAGCAAACTGCAGGTGGCTCATCCACAGCCCGTGAAGGGGCTACAAGCTG

Contig8298505 CTGGCTATATGAGCAAACTGCAGGTGGCTCATCCACAGCCCGTGAAGGGGCTACAAGCTG
HK1 laA-119_5p TAGTGCCAGTGGGATCAGGGCAGGTGGGGAAGCTGGGCGGGGTATGCCTGAGGGTAGAGG

Contig8298505 TAGTGCCAGTGGGATCAGGGCAGGTGGGGAAGCTGGGCGGGGTATGCCTGAGGGTAGAGG
HK1 laA-119_5p GGGCCCAGGGACTGAGCCGGTTACAGTGGCAGCGGCAGCAGTGACAGCAGCTC

Contig8298505 GGGCCCAGGGACTGAGCCGGTTACAGTGGCAGCGGCAGCAGTGACAGCAGCTC
Contig8298505 Consensus sequence >Contig8298505 653 nt CACACATCCATCTTCCTCAGGGGGCCACCAGGGTCCTCACCGCAACCTGCACCTTTGCGCCTTCGAGATTGGGCTTTAT
G
CCCTTGGCCTGCACAACTTTGTTTCTCCCAACTGGCTCTCACGTACTTATTCTTCCCACGTTTCCTGGATTACAGGCCA
G
GCCATGGAGATAGGCAGCGCAGCCCTGACTATACTGGTAGAATGCTGGGATGGGCACCTGACACCCCCTGAGGTTGCAT
C
CCTGGCTGACAGGGCATCACGGGCAAGAGACTCCAATATGGTGAGGGCGGCAGCAGAGCTGGCCCTGAGCTGCCTGCCT
C
ACGCCCATGCATTGAACCCTAATGAGATCCAGCGGGCCCTGGTGCAGTGCAAGGAACAGGACAACCTGATGTTGGAGAA
G

Page 9 sur 136 GCCTGCATGGCAGTGGAAGAGGCAGCTAAGGGTGGGGGCGTGTACCCTGAAGTGTTGTTTGAGGTTGCTCACCAGTGGT
T
CTGGCTATATGAGCAAACTGCAGGTGGCTCATCCACAGCCCGTGAAGGGGCTACAAGCTGTAGTGCCAGTGGGATCAGG
G
CAGGTGGGGAAGCTGGGCGGGGTATGCCTGAGGGTAGAGGGGGCCCAGGGACTGAGCCGGTTACAGTGGCAGCGGCAGC
A
GTGACAGCAGCTC

back to table Contig8298507 Alignment HK1 laA-215_5p NTTTTGAGTTCGTTGGCAATTTTACCCCCTTCCAGCTTCTCAAAAAGTTTTGGTTTTCTA

Contig8298507 NTTTTGAGTTCGTTGGCAATTTTACCCCCTTCCAGCTTCTCAAAAAGTTTTGGTTTTCTA
HK1 laA-215__5p GGCTTGGGGGTACTGCTACCCACGCCCGATGGGGCGCACCCTCTTGATTAAATTTTCTCT

Contig8298507 GGCTTGGGGGTACTGCTACCCACGCCCGATGGGGCGCACCCTCTTGATTAAATTTTCTCT
HK1 laA-215_5p CTTGCCTCTGGCTCTAGCCCACATCACGAGCAACAACGTCTGCCTATGGGGTGGCGCANG

Contig8298507 CTTGCCTCTGGCTCTAGCCCACATCACGAGCAACAACGTCTGCCTATGGGGTGGCGCANG
HK1 laA-215_5p GGTGGACGGGGTGTGTTTGTGTACACTGTGTGTGTATTGGGGTGTGCATGTGTGTACATC
HK1 laA-179_5p GGTGTGTTTGTGTACACTGTGTGTGTATGTGGGTGTGCATGTGTGTACATG

Contig8298507 GGTGGACGGGGTGTGTTTGTGTACACTGTGTGTGTATGGGGGTGTGCATGTGTGTACATC
HK1 laA-215_5p ATGTGTGTGTATGTGGGTGTGCTTGTGTGGACAAGGCATGCATGTGTGCATGTGGGATGC
HK1 1aA-179_5p GTGTGTGTGTATGTGGGTGTGCTTGTGTGTACATGGCATGCATGTGTGCATGTGGGATGC

Contig8298507 ATGTGTGTGTATGTGGGTGTGCTTGTGTGGACAAGGCATGCATGTGTGCATGTGGGATGC
HK1 laA-215_5p ATGTGTATGGGGCATGTGTGCATGGCGTGTGTGCACATGTTTGGGCAAGCATGCGTGTGT
HK1 laA-179_5p ATGTGTATGGGGCATGTGTGCATGGCGTGTGTGCACATGTCTGGGCATGCATGCGTGTGT

Contig8298507 ATGTGTATGGGGCATGTGTGCATGGCGTGTGTGCACATGTCTGGGCAAGCATGCGTGTGT
HK1 laA-215_5p CATGGGCATGCATGTGTGGGTATGCGGTGTGTTTTTTTGCAGGGGCCAGTGTTTGGGGGG
HK1 laA-179_5p CATGGGCATGCATGTGTGTGTATGCGGTGTGTTGCTCTGCAGGCCCCAGTGTTGGCCGGC

Contig8298507 CATGGGCATGCATGTGTGGGTATGCGGTGTGTTGCTCTGCAGGCCCCAGTGTTGGCCGGC
HK1 laA-215_Sp CCCCCCGTCTTTCCTGTAAGTGAATTCCTTC
HK1 laA-179_5p CCCCCCGTCTTTCCTGTAAGTGACTTCCTTCCTAGGAGGCTTGGTGTGACTGGCATTCCC

Contig8298507 CCCCCCGTCTTTCCTGTAAGTGAATTCCTTCCTAGGAGGCTTGGTGTGACTGGCATTCCC
HKl laA-179_5p TGGAAAGGGAGGGGCGGAT

Contig8298507 TGGAAAGGGAGGGGCGGAT

Contig8298507 Consensus sequence Page 10 sur 136 >Contig8298507 499 nt NTTTTGAGTTCGTTGGCAATTTTACCCCCTTCCAGCTTCTCAAAAAGTTTTGGTTTTCTAGGCTTGGGGGTACTGCTAC
C
CACGCCCGATGGGGCGCACCCTCTTGATTAAATTTTCTCTCTTGCCTCTGGCTCTAGCCCACATCACGAGCAACAACGT
C
TGCCTATGGGGTGGCGCANGGGTGGACGGGGTGTGTTTGTGTACACTGTGTGTGTATGGGGGTGTGCATGTGTGTACAT
C
ATGTGTGTGTATGTGGGTGTGCTTGTGTGGACAAGGCATGCATGTGTGCATGTGGGATGCATGTGTATGGGGCATGTGT
G
CATGGCGTGTGTGCACATGTCTGGGCAAGCATGCGTGTGTCATGGGCATGCATGTGTGGGTATGCGGTGTGTTGCTCTG
C
AGGCCCCAGTGTTGGCCGGCCCCCCCGTCTTTCCTGTAAGTGAATTCCTTCCTAGGAGGCTTGGTGTGACTGGCATTCC
C
TGGAAAGGGAGGGGCGGAT

back to table Contig8298510 Alignment HK1 laA-220_5p GCTGGGGGAAGCAGTCACATTAGGAGGTGGGCTGAAGGCCTGGGTTTGCTGCTGTTGCTG

Contig8298510 GCTGGGGGAAGCAGTCACATTAGGAGGTGGGCTGAAGGCCTGGGTTTGCTGCTGTTGCTG
HK1 laA-220_5p CTGTTGCTGTTGCTGTTATGTGGCACCTGCAGGGAAAATTACTTACCCATGAAAACCAAA

Contig8298510 CTGTTGCTGTTGCTGTTATGTGGCACCTGCAGGGAAAATTACTTACCCATGAAAACCAAA
HK1 1aA-220_5p TCTAAGTCAACAAGTTCTGAAAGGTACAAGGGACAAGCTCCAGATCTAATTGGCAANCAA

Contig8298510 TCTAAGTCAACAAGTTCTGAAAGGTACAAGGGACAAGCTCCAGATCTAATTGGCAANCAA
HK1 laA-220_5p GACANTGTGTATGAAGACTGGGACATGTTGGATGTTGATGAAAATGAAAANCTAACTGGT

Contig8298510 GACANTGTGTATGAAGACTGGGACATGTTGGATGTTGATGAAAATGAAAANCTAACTGGT
HK1 laA-220_5p GAAAAAAAATTTGANTTACTTGCTGGACCGCTTGGTTTAAATGACCGGCGCATTGTACCA

Contig8298510 GAAAAAP.AATTTGANTTACTTGCTGGACCGCTTGGTTTAAATGACCGGCGCATTGTACCA
HK1 laA-220_5p AAACCAGTTCAGTTCCCTGACAGCGATCCACTGGGAGCATCAGTAGCAATGGTCACAGCC

Contig8298510 AAACCAGTTCAGTTCCCTGACAGCGATCCACTGGGAGCATCAGTAGCAATGGTCACAGCC
HK1 1aA-220_5p ACCAACAGTATGGAAGATACTCTGATGCAAATAGGTTGCCATGGCTCCATAAAAAAGAAC

Contig8298510 ACCAACAGTATGGAAGATACTCTGATGCAAATAGGTTGCCATGGCTCCATAAAAAAGAAC
HK1 laA-220_5p TCCTCTGGGAGAGTAACGTTAGGAGAGCGCGCCCCTGCCCTAGCAAACCCTGGTGACCGT

Contig8298510 TCCTCTGGGAGAGTAACGTTAGGAGAGCGCGCCCCTGCCCTAGCAAACCCTGGTGACCGT
HK1 laA-220_5p GTGGT

Contig8298510 GTGGT

Page 11 sur 136 Contig8298510 Consensus sequence >Contig8298510 485 nt GCTGGGGGAAGCAGTCACATTAGGAGGTGGGCTGAAGGCCTGGGTTTGCTGCTGTTGCTGCTGTTGCTGTTGCTGTTAT
G
TGGCACCTGCAGGGAAAATTACTTACCCATGAAAACCAAATCTAAGTCAACAAGTTCTGAAAGGTACAAGGGACAAGCT
C
CAGATCTAATTGGCAANCAAGACANTGTGTATGAAGACTGGGACATGTTGGATGTTGATGAAAATGAAAANCTAACTGG
T
GAAAAAAAATTTGANTTACTTGCTGGACCGCTTGGTTTAAATGACCGGCGCATTGTACCAAAACCAGTTCAGTTCCCTG
A
CAGCGATCCACTGGGAGCATCAGTAGCAATGGTCACAGCCACCAACAGTATGGAAGATACTCTGATGCAAATAGGTTGC
C
ATGGCTCCATAAAAAAGAACTCCTCTGGGAGAGTAACGTTAGGAGAGCGCGCCCCTGCCCTAGCAAACCCTGGTGACCG
T
GTGGT

back to table Contig8298512 Alignment HK1 laA-215_3p NNNNNNNNN NNNNNNNNN

Contig8298512 HK1 laA-215_3p Contig8298512 HK1 laA-215_3p Contig8298512 HK1 laA- 215_3 p Nrmf~~JNNNNNNNNNNNNNNN

Contig8298512 NNNNNNN

HK1 laA-215_3p NTATTGGTCCCATTTTCTGATCTATTTTTCCCTCTTGCCTCTGGCTCTAGCCCACATCGG
HK1 laA-179_3p TATTGGTCCCATTTTCTGATCTATTTTTCCCTCTTGCCTCTGGCTCTAGCCCACATCGG

Contig8298512 NTATTGGTCCCATTTTCTGATCTATTTTTCCCTCTTGCCTCTGGCTCTAGCCCACATCGG
HK1 laA-215_3p TGCATGTGTGTGTGTGTATGTGGGTG
HK1 laA-179_3p TGCATGTGTGTGTGTGTATGTGGGTGAACAAAGGAAAACCGAAAAAGGCACAAAANAACG

Contig8298512 TGCATGTGTGTGTGTGTATGTGGGTGAACAAAGGAAAACCGAAAAAGGCACAAAANAACG
HK1 1aA-179_3p CACCACGAAAAAAGAAGGGGACGGGACGGGGGAGAGAGAAGAAGGGGGGGAGAAGGAGCA

Contig8298512 CACCACGAAAAAAGAAGGGGACGGGACGGGGGAGAGAGAAGAAGGGGGGGAGAAGGAGCA
HK1 laA-179_3p GGGGGGAAGGGAGGAAAAGAAGGAGAAGAT

Contig8298512 GGGGGGAAGGGAGGAAAAGAAGGAGAAGAT

IContig8298512 Consensus sequence Page 12 sur 136 >Contig8298512 450 nt ANNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNDINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
N
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
N
NTATTGGTCCCATTTTCTGATCTATTTTTCCCTCTTGCCTCTGGCTCTAGCCCACATCGGTGCATGTGTGTGTGTGTAT
G
TGGGTGAACAAAGGAAAACCGAAAAAGGCACAAAANAACGCACCACGAAAAAAGAAGGGGACGGGACGGGGGAGAGAGA
P.
GAAGGGGGGGAGAAGGAGCAGGGGGGAAGGGAGGAAAAGAAGGAGAAGAT

back to table Contig8298513 Alignment HK1 laA-49_3p CCGTTCTATCTTTCTGCTCCTCTTCTCCTGTTTCCGGTCGCCGTTTGCTCCCGTCCGCCC

Contig8298513 CCGTTCTATCTTTCTGCTCCTCTTCTCCTGTTTCCGGTCGCCGTTTGCTCCCGTCCGCCC
HK1 laA-49_3p TTTCCTGCCTTCGGCGCGCGGTCCGCCCCCACCTCTATGCCCCGGACTCTCACCTCTTTC

Contig8298513 TTTCCTGCCTTCGGCGCGCGGTCCGCCCCCACCTCTATGCCCCGGACTCTCACCTCTTTC
HK1 laA-49_3p TCTCTCTCTTTCCTCCTCTTCCGTTTCGTCTTCGCTCCCTCTATCTCCTCCCTCCGTCCT

Contig8298513 TCTCTCTCTTTCCTCCTCTTCCGTTTCGTCTTCGCTCCCTCTATCTCCTCCCTCCGTCCT
HK1 laA-49_3p TCTCTCTTGCCCCCCTCTCGTCCTGCCTCCTCCATCTCTCCTGGTCCCCTTCCCTGCTCT

Contig8298513 TCTCTCTTGCCCCCCTCTCGTCCTGCCTCCTCCATCTCTCCTGGTCCCCTTCCCTGCTCT
HK1 laA-49_3p TGTTCACTCCCTCCTGCGCCCTTCCCCCCCCTTCCCACACTCTCCTTCGTCCCTTTCCTT

Contig8298513 TGTTCACTCCCTCCTGCGCCCTTCCCCCCCCTTCCCACACTCTCCTTCGTCCCTTTCCTT
HK1 laA-49_3p TCTTTTTCTTTTCTTGTTATGGTTTCGGGGGGTGCCGCCTTTTTTTTTTTTTTTTCCGCT

Contig8298513 TCTTTTTCTTTTCTTGTTATGGTTTCGGGGGGTGCCGCCTTTTTTTTTTTTTTTTCCGCT
HK1 laA-49_3p CCGCTCCCTTCTCTGGTCGTCTGGTTTTTTTCTCCTCTTTCCGCTTCTGGGGGGGGGGGT

Contig8298513 CCGCTCCCTTCTCTGGTCGTCTGGTTTTTTTCTCCTCTTTCCGCTTCTGGGGGGGGGGGT
HK1 laA-49_3p TTTTCTTTCTCCCCCCTTTTCTTTCTTTCGTTTTTCCCCGCGCCCTCCTTAAAAAAAAAC

Contig8298513 TTTTCTTTCTCCCCCCTTTTCTTTCTTTCGTTTTTCCCCGCGCCCTCCTTAAAAAAAAAC
HK1 laA-49_3p TTTGTCCTTTCCCTCTTCGTCGTCGGCGATTTTTCTACACCGCCCCCGGCACGCTTTCCC

Contig8298513 TTTGTCCTTTCCCTCTTCGTCGTCGGCGATTTTTCTACACCGCCCCCGGCACGCTTTCCC
HK1 laA-49_3p CATTGATTTGTGTGCCCCGGNNNNAAATCAGAAACACCG

Page 13 sur 136 Contig8298513 CATTGATTTGTGTGCCCCGGNNNNAAATCAGAAACACCG

Contig8298513 Consensus sequence >Contig8298513 579 nt CCGTTCTATCTTTCTGCTCCTCTTCTCCTGTTTCCGGTCGCCGTTTGCTCCCGTCCGCCCTTTCCTGCCTTCGGCGCGC
G
GTCCGCCCCCACCTCTATGCCCCGGACTCTCACCTCTTTCTCTCTCTCTTTCCTCCTCTTCCGTTTCGTCTTCGCTCCC
T
CTATCTCCTCCCTCCGTCCTTCTCTCTTGCCCCCCTCTCGTCCTGCCTCCTCCATCTCTCCTGGTCCCCTTCCCTGCTC
T
TGTTCACTCCCTCCTGCGCCCTTCCCCCCCCTTCCCACACTCTCCTTCGTCCCTTTCCTTTCTTTTTCTTTTCTTGTTA
T
GGTTTCGGGGGGTGCCGCCTTTTTTTTTTTTTTTTCCGCTCCGCTCCCTTCTCTGGTCGTCTGGTTTTTTTCTCCTCTT
T
CCGCTTCTGGGGGGGGGGGTTTTTCTTTCTCCCCCCTTTTCTTTCTTTCGTTTTTCCCCGCGCCCTCCTTAAAAAAAAA
C
TTTGTCCTTTCCCTCTTCGTCGTCGGCGATTTTTCTACACCGCCCCCGGCACGCTTTCCCCATTGATTTGTGTGCCCCG
G
NNNNAAATCAGAAACACCG

back to table Contig8298515 Alignment HK1 laA-32_5p AACCGCCTCGGACGCCGCTGCTGTGGCTGCTGCTGCTGCTGCTGGCCGCCGTGGCGCCGG
HK1 laA-9_5p CCGCCGCGGACGCCGCTGCTGTGGCTGCTGCTGCTGCTGCTGGCCGCCGTGGCGCCGG

Contig8298515 AACCGCCGCGGACGCCGCTGCTGTGGCTGCTGCTGCTGCTGCTGGCCGCCGTGGCGCCGG
HK1 laA-32_5p CGCGCGGCTGGGAAAGCGGAAACCTGGATTTGTTTGACTTAGTGGAGGAGGTGCACCTCA
HK1 laA-9_5p CGCGCGGCTGGGAGAGCGGAGACCTGGAGTTGTTTGACTTAGTGGAGGAGGTGCAGCTCA

Contig8298515 CGCGCGGCTGGGAAAGCGGAAACCTGGAGTTGTTTGACTTAGTGGAGGAGGTGCACCTCA
HK1 laA-32_5p ACTTCTACCATTTCCTCGGGGTGCAGCAGGATGCATCATCTGCAAACATCAAAAAAGCAT
HK1 laA-9_5p ACTTCTACCAGTTCCTCGGGGTGCAGCAGGATGCATCATCTGCAGACATCAGAAAAGCAT

Contig8298515 ACTTCTACCAGTTCCTCGGGGTGCAGCAGGATGCATCATCTGCAAACATCAAAAAAGCAT
HK1 laA-32_5p ATCGTAAGCTTTCACTAACTTTACATCCGGACAAGAATAAAGATGAAAATGCAGAACCTC
HK1 laA-9_5p ATCGTAAGCTTTCACTAACTTTACATCCAGACAAGAATAAAGATGAAAATGCAGAAACTC

Contig8298515 ATCGTAAGCTTTCACTAACTTTACATCCAGACAAGAATAAAGATGAAAATGCAGAAACTC
HK1 laA-32_5p ATTTTAGACAATTGGTGGCCATTTATGAATTTTTAAAGGATGATGAACGAAGGCAGAGGT
HK1 laA-9_5p ATTTTAGACAATTGGTGGCCATTTATGAAGTTTTAAAGGATGATGAACGAAGGCAGAGGT

Contig8298515 ATTTTAGACAATTGGTGGCCATTTATGAAGTTTTAAAGGATGATGAACGAAGGCAGAGGT
HK1 laA-32_5p ATGATGATATTCTGATCAATGGACTTCCAGAT
HK1 laA-9_5p ATGATGATCTTCTGATCACTGCACTTTCAGATCTGGCACCGCNCTGTCTTTCTACTTAAG

Contig8298515 ATGATGATATTCTGATCAATGCACTTCCAGATCTGGCACCGCNCTGTCTTTCTACTTAAG
HK1 laA-9_5p GGGGGGTGATNNAAATTGNNNNATGCCTCATNCTNCTCTTTCTTCNCGTTTCTTTTTTTG

Contig8298515 GGGGGGTGATNNAAATTGNNNNATGCCTCATNCTNCTCTTTCTTCNCGTTTCTTTTTTTG

Page 14 sur 136 HK1 laA-9_5p GNACGAGTNAGCTTTCTTATTNC

Contig8298515 GNACGAGTNAGCTTTCTTATTNC

Contig8298515 Consensus sequence >Contig8298515 443 nt AACCGCCGCGGACGCCGCTGCTGTGGCTGCTGCTGCTGCTGCTGGCCGCCGTGGCGCCGGCGCGCGGCTGGGAAAGCGG
A
AACCTGGAGTTGTTTGACTTAGTGGAGGAGGTGCACCTCAACTTCTACCAGTTCCTCGGGGTGCAGCAGGATGCATCAT
C
TGCAAACATCAAAAP.AGCATATCGTAAGCTTTCACTAACTTTACATCCAGACAAGAATAAAGATGAAAATGCAGAAAC
TC
ATTTTAGACAATTGGTGGCCATTTATGAAGTTTTAAAGGATGATGAACGAAGGCAGAGGTATGATGATATTCTGATCAA
T
GCACTTCCAGATCTGGCACCGCNCTGTCTTTCTACTTAAGGGGGGGTGATNNAAATTGNNNNATGCCTCATNCTNCTCT
T
TCTTCNCGTTTCTTTTTTTGGNACGAGTNAGCTTTCTTATTNC
back to table Contig8298518 Alignment HK1 1aA-220_3p GGTTCTTCTGGCCAGAACCATGGTCATGAGAGCGCTGTCTCTTCTCTCAGTCAGTGGTTC

Contig8298518 GGTTCTTCTGGCCAGAACCATGGTCATGAGAGCGCTGTCTCTTCTCTCAGTCAGTGGTTC
HK1 laA-220_3p CAGTTGTAGCCTGGCTGCTGGTCTTGAGTCTCTGGGGCTAACAGATATCCGAACGCTAGT

Contig8298518 CAGTTGTAGCCTGGCTGCTGGTCTTGAGTCTCTGGGGCTAACAGATATCCGAACGCTAGT
HK1 laA-220_3p TCGATTAATGTGCTTGGCAGCAGCAGGGAGAGCTGGCCTCTCCACCAGCCCTTCTGCCAT

Contig8298518 TCGATTAATGTGCTTGGCAGCAGCAGGGAGAGCTGGCCTCTCCACCAGCCCTTCTGCCAT
HK1 laA-220_3p GGCTAGCACCTCAGCTACGATCACGAGGTGGGCATAGCAAGGCTAACAAGCCTATCTCTT

Contig8298518 GGCTAGCACCTCAGCTACGATCACGAGGTGGGCATAGCAAGGCTAACAAGCCTATCTCTT
HK1 laA-220_3p GCCTGGCCTATTTGAGCACAGCAGTGGGATGTCTGGCATCAAATGCTCCTAGTGCTGCCA

Contig8298518 GCCTGGCCTATTTGAGCACAGCAGTGGGATGTCTGGCATCAAATGCTCCTAGTGCTGCCA
HK1 laA-220_3p AACTGCTTGTACAGTTGTGTACACAGAACTTGATTTCTGCTGCAACAGGTGTAAATCTAA

Contig8298518 AACTGCTTGTACAGTTGTGTACACAGAACTTGATTTCTGCTGCAACAGGTGTAAATCTAA
HK1 laA-220_3p CCACAGTTGATGACTCAATTCAGCGAAAGTTTCTACCCAGCTTTCTCCGAGGAATTGCTG

Contig8298518 CCACAGTTGATGACTCAATTCAGCGAAAGTTTCTACCCAGCTTTCTCCGAGGAATTGCTG
HK1 1aA-220_3p AAGAGAACAAGCTTGTGACCTC

Page 15 sur 136 Contig8298518 AAGAGAACAAGCTTGTGACCTC

Contig8298518 Consensus sequence >Contig8298518 442 nt GGTTCTTCTGGCCAGAACCATGGTCATGAGAGCGCTGTCTCTTCTCTCAGTCAGTGGTTCCAGTTGTAGCCTGGCTGCT
G
GTCTTGAGTCTCTGGGGCTAACAGATATCCGAACGCTAGTTCGATTAATGTGCTTGGCAGCAGCAGGGAGAGCTGGCCT
C
TCCACCAGCCCTTCTGCCATGGCTAGCACCTCAGCTACGATCACGAGGTGGGCATAGCAAGGCTAACAAGCCTATCTCT
T
GCCTGGCCTATTTGAGCACAGCAGTGGGATGTCTGGCATCAAATGCTCCTAGTGCTGCCAAACTGCTTGTACAGTTGTG
T
ACACAGAACTTGATTTCTGCTGCAACAGGTGTAAATCTAACCACAGTTGATGACTCAATTCAGCGAAAGTTTCTACCCA
G
CTTTCTCCGAGGAATTGCTGAAGAGAACAAGCTTGTGACCTC

back to table Contig8298519 Alignment HK1 laA-133_5p ACCAGCCACTGGAAATACTGCTCCCGAGCCGTTCTTGGTAAAGGCCTT
HK1 laA-163_5p CTGCACGTCAGCACCAGCCACTGGAAATACTGCTCCCGAGCCGTTCTTGGTAAAGGCCTT

Contig8298519 CTGCACGTCAGCACCAGCCACTGGAAATACTGCTCCCGAGCCGTTCTTGGTAAAGGCCTT
HK1 laA-133_5p GAAGAACCTCACAGTCGGGAAGCCAGGGATGTTGAAGTCTCTGCAGACTGCACTGTTGGT
HK1 laA-163_5p GAAGAACCTCACAGTCGGGAAGCCAGGGATGTTGAAGTCTCTGCAGACTGCACTGTTGGT

Contig8298519 GAAGAACCTCACAGTCGGGAAGCCAGGGATGTTGAAGTCTCTGCAGACTGCACTGTTGGT
HK1 laA-133_5p CTCCTCAGCACAGTCCAGGGCGGCGAGATACAGGGCCGGCCTCCAGGCTTTGACGTCTTC
HK1 laA-163_5p CTCCTCAGCACAGTCCAGGGCGGCGAGATACAGGGCCGGCCTCCAGGCTTTGACGTCTTC

Contig8298519 CTCCTCAGCACAGTCCAGGGCGGCGAGATACAGGGCCGGCCTCCAGGCTTTGACGTCTTC
HK1 1aA-133_5p GGCCAGGGCCTTCCACGTCGGGGCGAAGGCGATGCAGTGGCCGCACCAGGAGGCGAAGAA
HK1 laA-163_5p GGCCAGCGCCTTCCACGTCGGGGCGAAGGCGATGCAGTGGCCGCACCAGGAGGCGAAGAA

Contig8298519 GGCCAGCGCCTTCCACGTCGGGGCGAAGGCGATGCAGTGGCCGCACCAGGAGGCGAAGAA
HK1 laA-133_5p CTCCACGGCCCAGGCGCTGCGGGAGCCCAGCACCGCGCCGCGCACCGTGTCCGCCTGCAG
HK1 laA-163_5p CTCCACGGCCCAGGCGCTGCGGGAGCCCAGCACCGCGCCGCGCACCGTGTCCGCCTGCAG

Contig8298519 CTCCACGGCCCAGGCGCTGCGGGAGCCCAGCACCGCGCCGCGCACCGTGTCCGCCTGCAG
HK1 laA-133_5p CAGCGTCAGCGGGTCGGAAGGCGAATAGAGCGCCGACCGCGGGGCCGCGTTAGCGCCGGG
HK1 laA-163_5p CAGCGTCAGCGGGTCGGAAGGCGAATAGAGCGCCGACCGCGGGGCCGCGTTAGCGCCGGG

Contig8298519 CAGCGTCAGCGGGTCGGAAGGCGAATAGAGCGCCGACCGCGGGGCCGCGTTAGCGCCGGG
HK1 laA-133_5p AACCGCGAGCAGCCACAGCAGCAGCAGCAGCAGCGACGGCGGCGGCCCGGAGCCGCT
HK1 laA-163_5p AACCGCGAGCAGCCGCAGCAGCAGCAGCAGCAGCGACGGCGGCGGCCCGGAGCC

Contig8298519 AACCGCGAGCAGCCACAGCAGCAGCAGCAGCAGCGACGGCGGCGGCCCGGAGCCGCT

Page 16 sur 136 Contig8298519 Consensus sequence >Contig8298519 417 nt CTGCACGTCAGCACCAGCCACTGGAAATACTGCTCCCGAGCCGTTCTTGGTAAAGGCCTTGAAGAACCTCACAGTCGGG
A
AGCCAGGGATGTTGAAGTCTCTGCAGACTGCACTGTTGGTCTCCTCAGCACAGTCCAGGGCGGCGAGATACAGGGCCGG
C
CTCCAGGCTTTGACGTCTTCGGCCAGCGCCTTCCACGTCGGGGCGAAGGCGATGCAGTGGCCGCACCAGGAGGCGAAGA
A
CTCCACGGCCCAGGCGCTGCGGGAGCCCAGCACCGCGCCGCGCACCGTGTCCGCCTGCAGCAGCGTCAGCGGGTCGGAA
G
GCGAATAGAGCGCCGACCGCGGGGCCGCGTTAGCGCCGGGAACCGCGAGCAGCCACAGCAGCAGCAGCAGCAGCGACGG
C
GGCGGCCCGGAGCCGCT

back to table Contig8298522 Alignment HK1 1aA-70_Sp AAAGCATCGCCGCCGCCCCGGGCTCTGCCCCCCGCCGCTGGAGCTGCTGCTGCTGCTGCT

Contig8298522 AAAGCATCGCCGCCGCCCCGGGCTCTGCCCCCCGCCGCTGGAGCTGCTGCTGCTGCTGCT
HK1 laA-70_Sp GTTCAGCCTCGGGCTGCTCCACGCAGGTGACTGCCAACAGCCTTCCTATGTCGAATCCAG

Contig8298522 GTTCAGCCTCGGGCTGCTCCACGCAGGTGACTGCCAACAGCCTTCCTATGTCGAATCCAG
HK1 laA-70-5p AAATGCACCACGGACTTCGTGTCCCTGACTTCTCACCTGAACTCTGCCGTTGACGGCTTT

Contig8298522 AAATGCACCACGGACTTCGTGTCCCTGACTTCTCACCTGAACTCTGCCGTTGACGGCTTT
HK1 1aA-70_5p GACTCTGATTTTTGCAAGGCCTTGCGTGCCTATGCTGGCTGCACCCAACGAACTTCAAAA

Contig8298522 GACTCTGATTTTTGCAAGGCCTTGCGTGCCTATGCTGGCTGCACCCAACGAACTTCAAAA
HK1 laA-70-5p GCCTGCCGTGGCAACCTGGTATACCATTCTGCCGTGTTGGGTATCAGTGACCTCATGAGC

Contig8298522 GCCTGCCGTGGCAACCTGGTATACCATTCTGCCGTGTTGGGTATCAGTGACCTCATGAGC
HK1 laA-70-5p CAAAGGAATTGTTCCAAGGATGGACCCACATCCTCTACCAACCCGGAAGTGACCCATGAT

Contig8298522 CAAAGGAATTGTTCCAAGGATGGACCCACATCCTCTACCAACCCGGAAGTGACCCATGAT
HK1 laA-70-5p CCTTGCAACTATCACAGCCACGCTGGAGCCAGGGAACACAGGN

Contig8298522 CCTTGCAACTATCACAGCCACGCTGGAGCCAGGGAACACAGGN
Contig8298522 Consensus sequence >Contig8298522 403 nt AAAGCATCGCCGCCGCCCCGGGCTCTGCCCCCCGCCGCTGGAGCTGCTGCTGCTGCTGCTGTTCAGCCTCGGGCTGCTC
C
ACGCAGGTGACTGCCAACAGCCTTCCTATGTCGAATCCAGAAATGCACCACGGACTTCGTGTCCCTGACTTCTCACCTG
A
ACTCTGCCGTTGACGGCTTTGACTCTGATTTTTGCAAGGCCTTGCGTGCCTATGCTGGCTGCACCCAACGAACTTCAAA
A
GCCTGCCGTGGCAACCTGGTATACCATTCTGCCGTGTTGGGTATCAGTGACCTCATGAGCCAAAGGAATTGTTCCAAGG
A

Page 17 sur 136 TGGACCCACATCCTCTACCAACCCGGAAGTGACCCATGATCCTTGCAACTATCACAGCCACGCTGGAGCCAGGGAACAC
A
GGN

back to table Contig8298524 Alignment HK1 laA-182_5p CGGAGGTGGCGGCGGCGGCGGCGGCGGCTGCTGCTGCTGCTGCTGCCCGCGTCCGAGGCT
HK1 1aA-160_5p CGGAGGTGGCGGCGGCGGCGGCGGCGGCTGCTGCTGCTGCTGCTGCCCGCGTCCGAGGCT
HK1 laA-122_5p CGGAGGTGGCGGCGGCGGCGGCGGCGGCTGCTGCTGCTGCTGCTGCCCGCGTCCGAGGCT

Contig8298524 CGGAGGTGGCGGCGGCGGCGGCGGCGGCTGCTGCTGCTGCTGCTGCCCGCGTCCGAGGCT
HK1 laA-182_5p CGCGGGCGGCGGGCCCGGGTGAGTGCACACCCGGCGCGCTGCCGGGCTCCCGGATGTGTC
HK1 1aA-160_5p CGCGGGCGGCGGGCCCGGGTGAGTGCACACCCGGCGCGCTGCCGGGCTCCCGGATGTGTC
HK1 laA-122_5p CGCGGGCGGCGGGCCCGGGTGAGTGCACACCCGGCGCGCTGCCGGGCTCCCGGATGTGTC

Contig8298524 CGCGGGCGGCGGGCCCGGGTGAGTGCACACCCGGCGCGCTGCCGGGCTCCCGGATGTGTC
HK1 1aA-182_5p ACCTTGTCCCGCTGCAGCCGAGATGCCGGGGGAGCGGGGCCTTCCACACCCCCTCCGTGG
HK1 1aA-160_5p ACCTTGTCCCGCTGCAGCCGAGATGCCGGGGGAGCGGGGCCTTCCACACCCCCTCCGTGG
HK1 1aA-122_5p ACCTTGTCCCGCTGCAGCCGAGATGCCGGGGGAGCGGGGCCTTCCACACCCCCTCCGTGG

Contig8298524 ACCTTGTCCCGCTGCAGCCGAGATGCCGGGGGAGCGGGGCCTTCCACACCCCCTCCGTGG
HK1 laA-182_5p GTGTGTGGTGAGTGTGGGTGTGTGCGCGTCTCCTCGCGTCCCTCGCTGAGGTGCCTACTG
HKi IaA-160_5p GTGTGTGGTGAGTGTGGGTGTGTGCGCGTCTCCTCGCGTCCCTCGCTGAGGTGCCTACTG
HK1 laA-122_5p GTGTGTGGTGAGTGTGGGTGTGTGCGCGTCTCCTCGCGTCCCTCGCTGAGGTGCCTACTG

Contig8298524 GTGTGTGGTGAGTGTGGGTGTGTGCGCGTCTCCTCGCGTCCCTCGCTGAGGTGCCTACTG
HK1 laA-182_5p TGTCTGCATGGGTTGGGGTCCCGCGCGATGAGGGGGTGTGGCCGCCATTGCCTGCCCCAG
HK1 laA-160_5p TGTCTGCATGGGTTGGGGTCCCGCGCGATGAGGGGGTGTGGCCGCCATTGCCTGCCCCAG
HK1 laA-122_5p TGTCTGCATGGGTTGGGGTCCCGCGCGATGAGGGGGTGTGGCCGCCATTGCCTGCCCCAG

Contig8298524 TGTCTGCATGGGTTGGGGTCCCGCGCGATGAGGGGGTGTGGCCGCCATTGCCTGCCCCAG
HK1 laA-182_5p TGGGTTTGCCCCCTTGGTCTGGTGCCCCTTCGCGAGCGAGGCCCTGGGATGCCGGTGCGA
HK1 laA-160_5p TGGGTTTGCCCCCTTGGTCTGGTGCCCCTTCGCGAGCGAGGCCCTGGGATGCCGGTGCGA
HK1 laA-122_5p TGGGTTTGCCCCCTTGGTCTGGTGCCCCTTCGCGAGCGAGGCCCTGGGATGCCGGTGCGA

Contig8298524 TGGGTTTGCCCCCTTGGTCTGGTGCCCCTTCGCGAGCGAGGCCCTGGGATGCCGGTGCGA
HK1 laA-182_5p GGGTGTGAGTAGTCCCTTTGTGCGCAAC
HK1 laA-160_5p GGGTGTGAGTAGTCCCTTTGTGCGCAAC
HK1 laA-122_5p GGGTGTGAGTAGTCCCTTTGTGCGCAACTTCGTGGCCC

Contig8298524 GGGTGTGAGTAGTCCCTTTGTGCGCAACTTCGTGGCCC

Contig8298524 Consensus sequence >Contig8298524 398 nt Page 18 sur 136 CGGAGGTGGCGGCGGCGGCGGCGGCGGCTGCTGCTGCTGCTGCTGCCCGCGTCCGAGGCTCGCGGGCGGCGGGCCCGGG
T
GAGTGCACACCCGGCGCGCTGCCGGGCTCCCGGATGTGTCACCTTGTCCCGCTGCAGCCGAGATGCCGGGGGAGCGGGG
C
CTTCCACACCCCCTCCGTGGGTGTGTGGTGAGTGTGGGTGTGTGCGCGTCTCCTCGCGTCCCTCGCTGAGGTGCCTACT
G
TGTCTGCATGGGTTGGGGTCCCGCGCGATGAGGGGGTGTGGCCGCCATTGCCTGCCCCAGTGGGTTTGCCCCCTTGGTC
T
GGTGCCCCTTCGCGAGCGAGGCCCTGGGATGCCGGTGCGAGGGTGTGAGTAGTCCCTTTGTGCGCAACTTCGTGGCCC
back to tablc Contig8298528 Alignment HK1 laA-70_3p GGACCAGAACCCTCCCAGTTACCTTTTTTGTGGCTTGTTTGGAGATCCTCACCTCAGAAC

Contig8298528 GGACCAGAACCCTCCCAGTTACCTTTTTTGTGGCTTGTTTGGAGATCCTCACCTCAGAAC
HK1 laA-70_3p TTTCAAGGATAACTTCCAAACATGCAAAGTAGAAGGGGCCTGGCCACTCATAGATAATAA

Contig8298528 TTTCAAGGATAACTTCCAAACATGCAAAGTAGAAGGGGCCTGGCCACTCATAGATAATAA
HK1 laA-70_3p TTATCTTTCAGTTCAAGTGACAAACGTACCTGTGGTCCCTGGATCCAGTGCTACTGCTAC

Contig8298528 TTATCTTTCAGTTCAAGTGACAAACGTACCTGTGGTCCCTGGATCCAGTGCTACTGCTAC
HK1 laA-70_3p AAATAAGATCACTATTATCTTCAAAGCCCACCATGAGTGTACAGATCAGAAAGTCTACCA

Contig8298528 AAATAAGATCACTATTATCTTCAAAGCCCACCATGAGTGTACAGATCAGAAAGTCTACCA
HK1 laA-70_3p AGCTGTGACAGATGACCTGCCGGCCGCCTTTGTGGATGGCACCACCAGTGGTGGGGACAG

Contig8298528 AGCTGTGACAGATGACCTGCCGGCCGCCTTTGTGGATGGCACCACCAGTGGTGGGGACAG
HK1 1aA-70_3p CGATGCCAAGAGCCTGCGTATCGTGGAAAGGGAGAGTGGCCACTATGTGGAGATGCACGC

Contig8298528 CGATGCCAAGAGCCTGCGTATCGTGGAAAGGGAGAGTGGCCACTATGTGGAGATGCACGC
HK1 1aA-70_3p C

Contig8298528 C

Contig8298528 Consensus sequence >Contig8298528 361 nt GGACCAGAACCCTCCCAGTTACCTTTTTTGTGGCTTGTTTGGAGATCCTCACCTCAGAACTTTCAAGGATAACTTCCAA
A
CATGCAAAGTAGAAGGGGCCTGGCCACTCATAGATAATAATTATCTTTCAGTTCAAGTGACAAACGTACCTGTGGTCCC
T
GGATCCAGTGCTACTGCTACAAATAAGATCACTATTATCTTCAAAGCCCACCATGAGTGTACAGATCAGAAAGTCTACC
A
AGCTGTGACAGATGACCTGCCGGCCGCCTTTGTGGATGGCACCACCAGTGGTGGGGACAGCGATGCCAAGAGCCTGCGT
A
TCGTGGAAAGGGAGAGTGGCCACTATGTGGAGATGCACGCC

back to table Page 19 sur 136 Contig8298529 Alignment HK1 laA-37_3p CTCTATTCTTTTTTTCTCACTTTTTCTTTTTTCATTTGTTCTATTTCACTTCCTCTCTCT

Contig8298529 CTCTATTCTTTTTTTCTCACTTTTTCTTTTTTCATTTGTTCTATTTCACTTCCTCTCTCT
HK1 laA-37_3p TTATTTCTGTTTTCCTCTTCTCTTTTTTGTTCCTTTCTATCTCTCGTTTTTTCCCCCTCT

Contig8298529 TTATTTCTGTTTTCCTCTTCTCTTTTTTGTTCCTTTCTATCTCTCGTTTTTTCCCCCTCT
HK1 laA-37_3p TCTTTTTTCTTCTTCTCTCTTTTGTTACCTCAGTTCTTCTTCTTTTCTCGCTCCCTCTTT

Contig8298529 TCTTTTTTCTTCTTCTCTCTTTTGTTACCTCAGTTCTTCTTCTTTTCTCGCTCCCTCTTT
HK1 laA-37_3p CTTTTTCGTATTTCTTTTTCCTTTTCTCCCCCTCTTTTTTTTCTCTCCCTGATTTTTGTG

Contig8298529 CTTTTTCGTATTTCTTTTTCCTTTTCTCCCCCTCTTTTTTTTCTCTCCCTGATTTTTGTG
HK1 laA-37_3p CCCTCTTCTTTGCTTCTTCGGTTCCTTTTCGTTGCTTTTTTCTTCTTCTCTTGTCTTTTT

Contig8298529 CCCTCTTCTTTGCTTCTTCGGTTCCTTTTCGTTGCTTTTTTCTTCTTCTCTTGTCTTTTT
HK1 laA-37_3p TTTCATTTTCTTCGCTCTTTTCTCCTCCGTCTTTCGTTTTTTCCTTTTTTCCTTCTTCAC

Contig8298529 TTTCATTTTCTTCGCTCTTTTCTCCTCCGTCTTTCGTTTTTTCCTTTTTTCCTTCTTCAC
HK1 1aA-37_3p TGTTCTTTCATTTTTTTTTGCTTTCTTGTCTCGGTTTCTCTTCTTTTCTTCTTTAGTATT

Contig8298529 TGTTCTTTCATTTTTTTTTGCTTTCTTGTCTCGGTTTCTCTTCTTTTCTTCTTTAGTATT
HK1 laA-37_3p CTCGCTCCCACCACCCCCCTG

Contig8298529 CTCGCTCCCACCACCCCCCTG

Contig8298529 Consensus sequence >Contig8298529 441 nt CTCTATTCTTTTTTTCTCACTTTTTCTTTTTTCATTTGTTCTATTTCACTTCCTCTCTCTTTATTTCTGTTTTCCTCTT
C
TCTTTTTTGTTCCTTTCTATCTCTCGTTTTTTCCCCCTCTTCTTTTTTCTTCTTCTCTCTTTTGTTACCTCAGTTCTTC
T
TCTTTTCTCGCTCCCTCTTTCTTTTTCGTATTTCTTTTTCCTTTTCTCCCCCTCTTTTTTTTCTCTCCCTGATTTTTGT
G
CCCTCTTCTTTGCTTCTTCGGTTCCTTTTCGTTGCTTTTTTCTTCTTCTCTTGTCTTTTTTTTCATTTTCTTCGCTCTT
T
TCTCCTCCGTCTTTCGTTTTTTCCTTTTTTCCTTCTTCACTGTTCTTTCATTTTTTTTTGCTTTCTTGTCTCGGTTTCT
C
TTCTTTTCTTCTTTAGTATTCTCGCTCCCACCACCCCCCTG
back to table Contig8298532 Alignment HK1 1aA-55_3p AGCTTCTTTCGCCCTTTCCCCCTCTGTCGCCCCTGTACCCTTCTCTGGCGGTCCCTCTCT

Page 20 sur 136 Contig8298532 AGCTTCTTTCGCCCTTTCCCCCTCTGTCGCCCCTGTACCCTTCTCTGGCGGTCCCTCTCT
HK1 laA-55_3p CGCGCGTACGCTTCCATTTTCTCTGTGCCGGCCGGGCGCTTCTCGCCGCTGCTTCCCCCC

Contig8298532 CGCGCGTACGCTTCCATTTTCTCTGTGCCGGCCGGGCGCTTCTCGCCGCTGCTTCCCCCC
HK1 1aA-55_3p CCCTCTNCTCCCCCCCTCCCTCCCCCTCGTTCGGCCCTCCTCCCTCCTCCTCTTCTCTTC

Contig8298532 CCCTCTNCTCCCCCCCTCCCTCCCCCTCGTTCGGCCCTCCTCCCTCCTCCTCTTCTCTTC
HK1 laA-55_3p CATCTTCCTCTCAGGTGTTGTTCTTCTCGCCCCTCTTTCCGTACGCGCCCCCCCCCCCNC

Contig8298532 CATCTTCCTCTCAGGTGTTGTTCTTCTCGCCCCTCTTTCCGTACGCGCCCCCCCCCCCNC
HK1 laA-55_3p CTTTTTTTTTTTTTTTTCCTTTGTTTGTTNTCTCGTCTTATCCGTCTCGTCGTTTCCTCT

Contig8298532 CTTTTTTTTTTTTTTTTCCTTTGTTTGTTNTCTCGTCTTATCCGTCTCGTCGTTTCCTCT
HK1 1aA-55_3p CCGGGGGGGGGGTGTTCTGCCCGCCCCCGCCCTTTTTCTNGGGCGCGNCTTTCTTGGTTT

Contig8298532 CCGGGGGGGGGGTGTTCTGCCCGCCCCCGCCCTTTTTCTNGGGCGCGNCTTTCTTGGTTT
HK1 laA-55_3p TAAAAAAAAAACACATTCAAATGTGCATCCACACACACAGGCACACATGCATACAAGTGT

= Contig8298532 TAAAAP.AAAAACACATTCAAATGTGCATCCACACACACAGGCACACATGCATACAAGTGT
HK1 laA-55_3p GCACACATACATATGTGCACACACACACACAGGCACACACTTGGGAACCATA

Contig8298532 GCACACATACATATGTGCACACACACACACAGGCACACACTTGGGAACCATA
Contig8298532 Consensus sequence >Contig8298532 472 nt AGCTTCTTTCGCCCTTTCCCCCTCTGTCGCCCCTGTACCCTTCTCTGGCGGTCCCTCTCTCGCGCGTACGCTTCCATTT
T
CTCTGTGCCGGCCGGGCGCTTCTCGCCGCTGCTTCCCCCCCCCTCTNCTCCCCCCCTCCCTCCCCCTCGTTCGGCCCTC
C
TCCCTCCTCCTCTTCTCTTCCATCTTCCTCTCAGGTGTTGTTCTTCTCGCCCCTCTTTCCGTACGCGCCCCCCCCCCCN
C
CTTTTTTTTTTTTTTTTCCTTTGTTTGTTNTCTCGTCTTATCCGTCTCGTCGTTTCCTCTCCGGGGGGGGGGTGTTCTG
C
CCGCCCCCGCCCTTTTTCTNGGGCGCGNCTTTCTTGGTTTTAAAAAAAAAACACATTCAAATGTGCATCCACACACACA
G
GCACACATGCATACAAGTGTGCACACATACATATGTGCACACACACACACAGGCACACACTTGGGAACCATA
back to table Contig8298535 Alignment HK1 1aA-19_5p GGGACCACGGAGCCTGGTGACGCGGCGCTCCCCTGCCCGGGTCGGGTTGCCCAGGCGCCG

Contig8298535 GGGACCACGGAGCCTGGTGACGCGGCGCTCCCCTGCCCGGGTCGGGTTGCCCAGGCGCCG
HK1 laA-19_5p CCGCGGCGGCTGCTGCTGCTGCTGCCGCTGCTGCTGGGTAGGGGACTTCGAGTAACGGCC

Page 21 sur 136 Contig8298535 CCGCGGCGGCTGCTGCTGCTGCTGCCGCTGCTGCTGGGTAGGGGACTTCGAGTAACGGCC
HK1 laA-19_5p GAGGCCTCGGCCTCCTCCTCTGGGGCGGCGGTCGAGAACAGCAGCGCCATGGAGGAGCTC

Contig8298535 GAGGCCTCGGCCTCCTCCTCTGGGGCGGCGGTCGAGAACAGCAGCGCCATGGAGGAGCTC
HK1 laA-19_5p GTCACTGAAAAGGAGGCGGAAAAGAGCCACCGGCCAGACAGTGTGAGCCTGCTCACCTTC

Contig8298535 GTCACTGAAAAGGAGGCGGAAAAGAGCCACCGGCCAGACAGTGTGAGCCTGCTCACCTTC
HK1 laA-19_5p ATCCTGCTGCTCACGCTGGCCATCCTCACCATATGGCTCTTCAAGTACTGCCGGGTGCAC

Contig8298535 ATCCTGCTGCTCACGCTGGCCATCCTCACCATATGGCTCTTCAAGTACTGCCGGGTGCAC
HKl laA-19_5p TTTCTGCATGAGACCGGGCTGGCCATGATCTGTGGGCTCATCGTTGGGGTGATCCTGAGG

Contig8298535 TTTCTGCATGAGACCGGGCTGGCCATGATCTGTGGGCTCATCGTTGGGGTGATCCTGAGG
HK1 laA-19_5p TATGGTACCCCTGGCACCAGGGGCCGTGACAAATTACTCAATTGCACTCAAGAAAATCAG

Contig8298535 TATGGTACCCCTGGCACCAGGGGCCGTGACAAATTACTCAATTGCACTCAAGAAAATCAG
HK1 laA-19_5p GCCT

Contig8298535 GCCT

Contig8298535 Consensus sequence >Contig8298535 424 nt GGGACCACGGAGCCTGGTGACGCGGCGCTCCCCTGCCCGGGTCGGGTTGCCCAGGCGCCGCCGCGGCGGCTGCTGCTGC
T
GCTGCCGCTGCTGCTGGGTAGGGGACTTCGAGTAACGGCCGAGGCCTCGGCCTCCTCCTCTGGGGCGGCGGTCGAGAAC
A
GCAGCGCCATGGAGGAGCTCGTCACTGAAAAGGAGGCGGAAAAGAGCCACCGGCCAGACAGTGTGAGCCTGCTCACCTT
C
ATCCTGCTGCTCACGCTGGCCATCCTCACCATATGGCTCTTCAAGTACTGCCGGGTGCACTTTCTGCATGAGACCGGGC
T
GGCCATGATCTGTGGGCTCATCGTTGGGGTGATCCTGAGGTATGGTACCCCTGGCACCAGGGGCCGTGACAAATTACTC
P.
ATTGCACTCAAGAAAATCAGGCCT

back to table Contig8298538 Alignment HK1 laA-19_3p GGAGGACGGGGAGAGCTCAGCGGCGAGGGTGCAAGAAGCTTCACCAAACAGCGGAAGGCC

Contig8298538 GGAGGACGGGGAGAGCTCAGCGGCGAGGGTGCAAGAAGCTTCACCAAACAGCGGAAGGCC
HK1 laA-19_3p TGAGACTGTGGCGGAGGGCGGCCAGGAGTCCGGGCCGGGGCGCTTTGCAGCGAAGACTAT

Contig8298538 TGAGACTGTGGCGGAGGGCGGCCAGGAGTCCGGGCCGGGGCGCTTTGCAGCGAAGACTAT

Page 22 sur 136 HK1 laA-19_3p GGCGCCGGAAGGAAGGCGGAGGCGAAGGGGCACTGGGCTAGGGCCGTACAGGCGGAGATA

Contig8298538 GGCGCCGGAAGGAAGGCGGAGGCGAAGGGGCACTGGGCTAGGGCCGTACAGGCGGAGATA
HK1 laA-19_3p AGACAAAGATCGGAACAGCATTCAACACATATGTAAGGTGGAGCCCAGAAGTAGAAGACA

Contig8298538 AGACAAAGATCGGAACAGCATTCAACACATATGTAAGGTGGAGCCCAGAAGTAGAAGACA
HK1 laA-19_3p AGCAGCTGTACGAGCGAGGAGAACTTCATGTTCTACCTGCATGATCCGCGCGCTATTTAC

Contig8298538 AGCAGCTGTACGAGCGAGGAGAACTTCATGTTCTACCTGCATGATCCGCGCGCTATTTAC
HK1 laA-19_3p CTTCCAGAAGCACGTGATCAGCCGCGTTTTCATCATAGGAGCTTCAGTTGCTGTCTTCCT

Contig8298538 CTTCCAGAAGCACGTGATCAGCCGCGTTTTCATCATAGGAGCTTCAGTTGCTGTCTTCCT
HK1 laA-19_3p GGGCAGAGCCGCCCATATCTACCCGCTCTCTTTCTTCCTCAGCTTGGGCAGAAG

Contig8298538 GGGCAGAGCCGCCCATATCTACCCGCTCTCTTTCTTCCTCAGCTTGGGCAGAAG
Contig8298538 Consensus sequence >Contig8298538 414 nt GGAGGACGGGGAGAGCTCAGCGGCGAGGGTGCAAGAAGCTTCACCAAACAGCGGAAGGCCTGAGACTGTGGCGGAGGGC
G
GCCAGGAGTCCGGGCCGGGGCGCTTTGCAGCGAAGACTATGGCGCCGGAAGGAAGGCGGAGGCGAAGGGGCACTGGGCT
A
GGGCCGTACAGGCGGAGATAAGACAAAGATCGGAACAGCATTCAACACATATGTAAGGTGGAGCCCAGAAGTAGAAGAC
A
AGCAGCTGTACGAGCGAGGAGAACTTCATGTTCTACCTGCATGATCCGCGCGCTATTTACCTTCCAGAAGCACGTGATC
A
GCCGCGTTTTCATCATAGGAGCTTCAGTTGCTGTCTTCCTGGGCAGAGCCGCCCATATCTACCCGCTCTCTTTCTTCCT
C
AGCTTGGGCAGAAG

back to table Contig8298540 Alignment HK1 1aA-265_3p CGGTAACTAATCTCATGCTTAACAGTCTCACCAGACCGGCCACCATGCTGCCCACCAGCT
HK1 laA-32_3p CGGTAACTAATCTCATGCTTAACAGTCTCACCAAACCGGCCACCATGCTGCCCACCAGCT
HK1 laA-50_3p CGGTAACTAATCTCATGCTTAACAGTCTCACCAGACCGGCCACCATGCTGCCCACCAGCT
HK1 laA-210_3p CGGTAACTAATCTCATGCTTAACAGTCTCACCAGACCGGCCACCATGCTGCCCACCAGCT

Contig8298540 CGGTAACTAATCTCATGCTTAACAGTCTCACCAGACCGGCCACCATGCTGCCCACCAGCT
HK1 1aA-265_3p TCCACAGGCCTAAAACCAGCACGACCTTCCTTGAAGCCCCCAGATCGAGAATAATTCCTG
HK1 laA-32_3p TCCACAGGCCTAAAACCAGCACGACCTTCCTTGAAGCCCCCAGATCGAGAATAATTCCTG
HK1 laA-50_3p TCCACAGGCCTAAAACCAGCACGACCTTCCTTGAAGCCCCCAAATCGAGAATAATTCCTG
HK1 laA-210_3p TCCACAGGCCTAAAACCAGCACGACCTTCCTTGAAGCCCCCAGATCGAGAATAATTCCTG

Contig8298540 TCCACAGGCCTAAAACCAGCACGACCTTCCTTGAAGCCCCCAGATCGAGAATAATTCCTG
HK1 laA-265_3p GGTGCAGACATACGGCCGGTACCTGCAGCATTCCTGTTAATAAATGTCCTTGGTGGTAGG
HK1 1aA-32_3p GGTGCAGACATACGGCCGGTACCTGCAGCATTCCTGTTAATAAATGTCCTTGGTGGTAGG
HK1 laA-50_3p GGTGCAAACATACGGCCGGTACCTGCAGCATTCCTGTTAATAAATGTCCTTGGTGGTAGG

Page 23 sur 136 HK1 laA-210_3p GGTGCAGACATACGGCCGGTACCTGCAGCATTCCTGTTAATAAATGTCCTTGGTGGTAGG

Contig8298540 GGTGCAGACATACGGCCGGTACCTGCAGCATTCCTGTTAATAAATGTCCTTGGTGGTAGG
HK1 1aA-265_3p GTGCCCCCAAGACCCTGGTGGCGATGAGACTTGTTTAGCCGCTCACCGTTCCAGTTTGGA
HK1 1aA-32_3p GTGCCCCCAAGACCCTGCTGGCAATGAGACTTGTTTACCCGCTCACCGTTCCAGTTTG
HK1 laA-50_3p GTGCCCCCAAGACCCTGGTGGCGATGAAACTTGTTTAGCCGCTCACCGTTCCAGTTTGAA
HK1 laA-210_3p GTGCCCCCAAGACCCTGGTGGCGATGAGACTTGTTTAGCCGCTCACCGTTCCAGTTTGGA

Contig8298540 GTGCCCCCAAGACCCTGGTGGCGATGAGACTTGTTTAGCCGCTCACCGTTCCAGTTTGGA
HK1 laA-265_3p TCTCTTTGTGGAGGACTCCCATATCGGGGTTTCCGGATTCTTCGAGGTTTGATGTCATCA
HK1 laA-50_-3p TCTCTTTGTGGAGGACTCCCATATCGGGGTTTCCGGATTCTTCGAGGTTTGATGTCATCA
HK1 1aA-210_3p TCTCTTTGTGGAGGACTCCCATATCGGGGTTTCCGGATTCTTCGAGGTTTGATGTCATCA

Contig8298540 TCTCTTTGTGGAGGACTCCCATATCGGGGTTTCCGGATTCTTCGAGGTTTGATGTCATCA
HK1 1aA-265_3p GGATTATGAGCTGAGCGAATGTCATAACCATAAAGAGCAATGAGCTCCTGTCGGGACTTT
HK1 1aA-50_3p GGATTATGACCTGAGCGAATGTCATAACCATAAAGAACAGTGACCACCTGTCGAGACTT
HK1 1aA-210_3p GGATTATGAGCTGAGCGAATGTCATAACCATAAAGAGCAATGAGCTCCTGTCGGGACTTT

Contig8298540 GGATTATGAGCTGAGCGAATGTCATAACCATAAAGAGCAATGAGCTCCTGTCGGGACTTT
HK1 laA-265_3p GGGGCCTGCTCATCTTCCCGGAACTTGTCATGCTCCCCGCGACCCTCATCCTTCCATAGC
HK1 1aA-210_3p GGGGCCTGCTCATCTTCCCGGAACTTGTCATGCTCCCAGCGACCCTCATCCTTCCATAGC

Contig8298540 GGGGCCTGCTCATCTTCCCGGAACTTGTCATGCTCCCAGCGACCCTCATCCTTCCATAGC
HK1 laA-265_3p TTTCGCTGACGCCCCTT
HK1 laA-210_3p TTTCGCTGACGCCCCTTGGGTCTGACTTCCTCCTCCTGAGTTTGCCA

Contig8298540 TTTCGCTGACGCCCCTTGGGTCTGACTTCCTCCTCCTGAGTTTGCCA
Contig8298540 Consensus sequence >Contig8298540 467 nt CGGTAACTAATCTCATGCTTAACAGTCTCACCAGACCGGCCACCATGCTGCCCACCAGCTTCCACAGGCCTAAAACCAG
C
ACGACCTTCCTTGAAGCCCCCAGATCGAGAATAATTCCTGGGTGCAGACATACGGCCGGTACCTGCAGCATTCCTGTTA
A
TAAATGTCCTTGGTGGTAGGGTGCCCCCAAGACCCTGGTGGCGATGAGACTTGTTTAGCCGCTCACCGTTCCAGTTTGG
A
TCTCTTTGTGGAGGACTCCCATATCGGGGTTTCCGGATTCTTCGAGGTTTGATGTCATCAGGATTATGAGCTGAGCGAA
T
GTCATAACCATAAAGAGCAATGAGCTCCTGTCGGGACTTTGGGGCCTGCTCATCTTCCCGGAACTTGTCATGCTCCCAG
C
GACCCTCATCCTTCCATAGCTTTCGCTGACGCCCCTTGGGTCTGACTTCCTCCTCCTGAGTTTGCCA
back to table Contig8298544 Alignment HK1 laA-254_5p ACAACTTCATCGGAGATGTGGTGGAGAACACCGCCCCTGCTCGTGGTCTATATCGAGATC
HK1 laA-180_5p CGTGGTCTATATCGAGATC

Contig8298544 ACAACTTCATCGGAGATGTGGTGGAGAACACCGCCCCTGCTCGTGGTCTATATCGAGATC

Page 24 sur 136 HK1 laA-254_5p CTGGACCGGCACCTTTTCTTGGGCCGCGAGGTCCCTATCTCGAACGGCTCAGGATTCGTG
HK1 laA-180_5p CTGGACCGGCACCCTTTCTTGGGCCGCGAGGTCCCTATCTCGAACGGCTCAGGATTCGTG

Contig8298544 CTGGACCGGCACCCTTTCTTGGGCCGCGAGGTCCCTATCTCGAACGGCTCAGGATTCGTG
HK1 laA-254_5p GTGGCTGCCGATGGGCTCATTGTCACCAACGCCCTTGTGGTGGCTGATCGGCGCACACTC
HK1 laA-180_5p GTGGCTGCCGATGGGCTCATTGTCACCAACGCCCATGTGGTGGCTGATCGGCGCAGAGTC

Contig8298544 GTGGCTGCCGATGGGCTCATTGTCACCAACGCCCATGTGGTGGCTGATCGGCGCACACTC
HK1 1aA-254_5p CGTGTGAAACTGCTAAGCGGCGACACGTATGAGGCCGTGGTCACAGCTGTGGATCCCGTG
HK1 laA-180_5p CGTGTGAGACTGCTAAGCGGCGACACGTATGAGGCCGTGGTCACAGCTGTGGATCCCGTG
HK1 laA-187_5p GAGACTGCTAAGCGGCGACACGTATGAGGCCGTGGTCACAGCTGTGGATCCCGTG

Contig8298544 CGTGTGAGACTGCTAAGCGGCGACACGTATGAGGCCGTGGTCACAGCTGTGGATCCCGTG
HK1 laA-254_5p GCAAACATCNCAACGCTGAGGATTCAGACTAAGGCCCCCCTCCCCACGCTGCCTCTGGGA
HK1 1aA-180_5p GCAGACATCGCAACGCTGAGGATTCAGACTAAGGAGCCTCTCCCCACGCTGCCTCTGGGA
HK1 1aA-187_5p GCAGACATCGCAACGCTGAGGATTCAGACTAAGGAGCCTCTCCCCACGCTGCCTCTGGGA

Contig8298544 GCAGACATCGCAACGCTGAGGATTCAGACTAAGGAGCCTCTCCCCACGCTGCCTCTGGGA
HK1 laA-254_5p CCCTCAGCTGATGTCCGGCGAGGGGATTTTGTTGTTGCCATGGAAACTCCCTTTGCACTG
HK1 1aA-180_5p CGCTCAGCTGATGTCCGGCAAGGGGAGTTTGTTGTTGCCATGGGAAGTCCCTTTGCACTG
HK1 1aA-187_5p CGCTCAGCTGATGTCCGGCAAGGGGAGTTTGTTGTTGCCATGGGAAGTCCCTTTGCACTG

Contig8298544 CGCTCAGCTGATGTCCGGCAAGGGGAGTTTGTTGTTGCCATGGGAAGTCCCTTTGCACTG
HK1 laA-254_5p CAAAACACTATCACATCCGGTGTTGTTAGCTCTGCTCAGCGTCCAGCCAAAGACCTGGGA
HK1 laA-180_5p CAGAACACGATCACATCCGGCATTGTTAGCTCTGCTCAGCGTCCAACCAGAGACCTGGGA
HK1 1aA-187_5p CAGAACACGATCACATCCGGCATTGTTAGCTCTGCTCAGCGTCCAGCCAGAGACCTGGGA

Contig8298544 CAGAACACGATCACATCCGGCATTGTTAGCTCTGCTCAGCGTCCAGCCAGAGACCTGGGA
HK1 1aA-254,_5p CTCCCCGAAAGGAATGTGGAATACGTTCAAACTGATGCAGCTTTTGGTTTTGGAACCTCT
HK1 laA-180_5p CTCC
HK1 laA-187_5p CTCCCCCAAACCAATGTGGAATACATTCAAACTGATGCAGCTATTGATTTTGGAAACTCT

Contig8298544 CTCCCCCAAACCAATGTGGAATACATTCAAACTGATGCAGCTATTGATTTTGGAAACTCT
HK1 laA-254_5p GGAGGTCCCC
HK1 laA-187_5p GGAGGTCCCCTGGTTAACCTGGATGGGGAGGTGATTGGAGTGAACACCATGAAGGTCACA

Contig8298544 GGAGGTCCCCTGGTTAACCTGGATGGGGAGGTGATTGGAGTGAACACCATGAAGGTCACA
HK1 laA-187_5p GCTGGAATCTCCTTTGCCATCCCTTCTGATCGTCTTCGAGAGTTTCTGCATCGTGGGGAA

Contig8298544 GCTGGAATCTCCTTTGCCATCCCTTCTGATCGTCTTCGAGAGTTTCTGCATCGTGGGGAA
HK1 1aA-187_5p AAG

Contig8298544 AAG

Page 25 sur 136 Contig8298544 Consensus sequence >Contig8298544 603 nt ACAACTTCATCGGAGATGTGGTGGAGAACACCGCCCCTGCTCGTGGTCTATATCGAGATCCTGGACCGGCACCCTTTCT
T
GGGCCGCGAGGTCCCTATCTCGAACGGCTCAGGATTCGTGGTGGCTGCCGATGGGCTCATTGTCACCAACGCCCATGTG
G
TGGCTGATCGGCGCACACTCCGTGTGAGACTGCTAAGCGGCGACACGTATGAGGCCGTGGTCACAGCTGTGGATCCCGT
G
GCAGACATCGCAACGCTGAGGATTCAGACTAAGGAGCCTCTCCCCACGCTGCCTCTGGGACGCTCAGCTGATGTCCGGC
A
AGGGGAGTTTGTTGTTGCCATGGGAAGTCCCTTTGCACTGCAGAACACGATCACATCCGGCATTGTTAGCTCTGCTCAG
C
GTCCAGCCAGAGACCTGGGACTCCCCCAAACCAATGTGGAATACATTCAAACTGATGCAGCTATTGATTTTGGAAACTC
T
GGAGGTCCCCTGGTTAACCTGGATGGGGAGGTGATTGGAGTGAACACCATGAAGGTCACAGCTGGAATCTCCTTTGCCA
T
CCCTTCTGATCGTCTTCGAGAGTTTCTGCATCGTGGGGAAAAG
back to table Contig8298548 Alignment HK1 laA-254_3p GCTAGGTATAATTTTATTTTATATAAAAAGTGTTTCTGTGATTCTTCAGAGCCCAGGAGT
HK1 1aA-187_3p AGGTATAATTTTATTTTATATAAAAAGTGTTTCTGTGATTCTTCAGAGCCCAGGAGT

Contig8298548 GCTAGGTATAATTTTATTTTATATAAAAAGTGTTTCTGTGATTCTTCAGAGCCCAGGAGT
HK1 laA-254_3p CAGTGCTGGTGGTTGGAGGGACCTGCCCCCACTGGTTCATTTAACCCTCTGTCTCGGTGC
HK1 laA-187_3p CAGTGCTGGTGGTTGGAGGGACCTGCCCCCACTGGTTCATTTAACCCTCTGTCTCGGTGC.

Contig8298548 CAGTGCTGGTGGTTGGAGGGACCTGCCCCCACTGGTTCATTTAACCCTCTGTCTCGGTGC
HK1 laA-254_3p CCTCAGAACCTCAGCCAGAAAGGCAAGGAGGAAATCAGAGCAGGAGCCTCATACTCTTGG
HK1 laA-187_3p CCTCAGAACCTCAGCCAGAAAGGCAAGGAGGAAATCAGAGCAGGAGCCTCATACTCTTGG

Contig8298548 CCTCAGAACCTCAGCCAGAAAGGCAAGGAGGAAATCAGAGCAGGAGCCTCATACTCTTGG
HK1 1aA-254_3p TGATCTATTCATTCTGTGACCTCAGGGGTCACATATAAGGTCAGTGTTTCTCGTCCCCGC
HK1 laA-187_3p TGATCTATTCATTCTGTGACCTCAGGGGTCACATATAAGGTCAGTGTTTCTCGTCCCCGC

Contig8298548 TGATCTATTCATTCTGTGACCTCAGGGGTCACATATAAGGTCAGTGTTTCTCGTCCCCGC
HK1 laA-254_3p CGGATCTGCACTGCCAACTGGGATTGGGTTCGAACAGCTTCATAAACATCTTCAGCATTT
HK1 laA-187_3p CGGATCTGCACTGCCAACTGGGATTGGGTTCGAACAGCTTCATAAACATCTTCAGCATTT

Contig8298548 CGGATCTGCACTGCCAACTGGGATTGGGTTCGAACAGCTTCATAAACATCTTCAGCATTT
HK1 1aA-254_3p TGTACCATCTGCTCCCCAATGGCCAAAATCACATCACCAGGCCGCAGACCAGCCCGGTGT
HK1 laA-187_3p TGTACCATCTGCTCCCCAATGGCCAAAATCACATCACCAGGCCGCAGACCAGCCCGGTGT

Contig8298548 TGTACCATCTGCTCCCCAATGGCCAAAATCACATCACCAGGCCGCAGACCAGCCCGGTGT
HK1 laA-254_3p GCAGGGGAGCCCAGGATGACTTTATGGATGAGTACACCATGCTGAACATCGGGAAAGCTT
HK1 laA-187_3p GCAGGGGAGCCCAGGATGACTTTATGGATGAGTACCCCAGGCTGAACATCGGGAATGCTT

Contig8298548 GCAGGGGAGCCCAGGATGACTTTATGGATGAGTACACCAGGCTGAACATCGGGAAAGCTT
HK1 laA-254_3p GGTTCTCGAAGCTG

Page 26 sur 136 HK1 laA-187_3p GGTTCTCGAAGCTGGAGTGTGGCGGGGGAGCAGGAACTCAAGGTCAG

Contig8298548 GGTTCTCGAAGCTGGAGTGTGGCGGGGGAGCAGGAACTCAAGGTCAG
Contig8298548 Consensus sequence >Contig8298548 467 nt GCTAGGTATAATTTTATTTTATATAAAAAGTGTTTCTGTGATTCTTCAGAGCCCAGGAGTCAGTGCTGGTGGTTGGAGG
G
ACCTGCCCCCACTGGTTCATTTAACCCTCTGTCTCGGTGCCCTCAGAACCTCAGCCAGAAAGGCAAGGAGGAAATCAGA
G
CAGGAGCCTCATACTCTTGGTGATCTATTCATTCTGTGACCTCAGGGGTCACATATAAGGTCAGTGTTTCTCGTCCCCG
C
CGGATCTGCACTGCCAACTGGGATTGGGTTCGAACAGCTTCATAAACATCTTCAGCATTTTGTACCATCTGCTCCCCAA
T
GGCCAAAATCACATCACCAGGCCGCAGACCAGCCCGGTGTGCAGGGGAGCCCAGGATGACTTTATGGATGAGTACACCA
G
GCTGAACATCGGGAAAGCTTGGTTCTCGAAGCTGGAGTGTGGCGGGGGAGCAGGAACTCAAGGTCAG
back to table Contig8298549 Alignment HK1 laA-248_5p GGGGCGGGGGGGGTGCCCCACCGTATTCAGCGTGACTTTGGGGGAAAACTTTCT
HK1 laA-57_5p GCGGTGGTGGTGCCCCACTGTATTCAGCGTGACTTTGGTGGAAAACTTTCT
HKI laA-248_3p GGGGCGGTGGTGGTGCCCCACTGTATTCAGCGTGACTTTGGTGGAAAACTTTCT
HK1 laA-260_3p GCGGTGGTGGTGCCCCACTGTATTCAGCGTGACTTTGGTGGAAAACTTTCT
HK1 laA-59_5p CGTGACTTTGGTGGAAAACTTTCT
HK1 laA-57_3p GCGGTGGTGGTGCCCCACTGTATTCAGCGTGACTTTGGTGGAAAACTTTCT
HK1 laA-93_5p ACTTTCT
HK1 laA-273_3p GCGGTGGTGGTGCCCCACTGTATTCAGCGTGACTTTGGTGGAAAACTTTCT
HK1 laA-260_.5p GCGGTGGTGGTGCCCCACTGTATTCAGCGTGACTTTGGTGGAAAACTTTCT
HK1 1aA-273_5p GCGGTGGTGGTGCCCCACCGTTTTTAGCGTGACTTTGGTGGAAAACTTTCT
HK1 laA-274_5p GGGGGTGCCCCACCCTTTTTAGCGTGACTTTGGGGGAAAACTTTTT
HKI laA-29_5p GGGGGGGCCCCACTGTTTTTAGCGTGACTTTGGTGGAAAACTTTCT
HK1 laA-237_3p GGCGGGGGGCGGTGGTGGTGCCCCACTGTATTCAGCGTGACTTTGGTGGAAAACTTTCT
HK1 1aA-256_3p GGGCGGGGGGCGGTGGTGGTGCCCCACTGTATTCAGCGTGACTTTGGTGGAAAACTTTCT
HK1 laA-69_3p GGCGGGGGGCGGTGGTGGTGCCCCACTGTATTCAGCGTGACTTTGGTGGAAAACTTTCT
HK1 laA-226_3p GGCGGGGGGCGGTGGTGGTGCCCCACTGTATTCAGCGTGACTTTGGTGGAAAACTTTCT
HK1 laA-249__3p GGCGGGGGGCGGTGGTGGTGCCCCACTGTATTCAGCGTGACTTTGGTGGAAAACTTTCT
HK1 laA-249_5p GGCGGGGGGCGGTGGTGGTGCCCCACTGTATTCAGCGTGACTTTGGTGGAAAACTTTCT
HK1 laA-274_3p TGGGGGCGGTGGTGGTGCCCCACTGTATTCAGCGTGACTTTGGTGGAAAACTTTCT
HK1 laA-259_3p GGGGGCGGTGGTGGTGCCCCACTGTATTCAGCGTGACTTTGGTGGAAAACTTTCT
HK1 laA-33_3p GCGGTGGTGGTGCCCCACTGTATTCAGCGTGACTTTGGTGGAAAACTTTCT
HKI laA-93_3p GCGGTGGTGGTGCCCCACTGTATTCAGCGTGACTTTGGTGGAAAACTTTCT
HK1 laA-27_3p GGGGCGGTGGTGGTGCCCCACTGTATTCAGCGTGACTTTGGTGGAAAACTTTCT
HK1 laA-6_3p CGGTGGTGGTGCCCCACTGTATTCAGCGTGACTTTGGTGGAAAACTTTCT
HK1 laA-41_3p GCGGTGGTGGTGCCCCACTGTATTCAGCGTGACTTTGGTGGAAAACTTTCT
HKI laA-87_3p GCCCCACTGTATTCAGCGTGACTTTGGTGGAAAACTTTCT
HK1 laA-59_3p GCGGTGGTGGTGCCCCACTGTATTCAGCGTGACTTTGGTGGAAAACTTTCT
HK1 laA-29_3p CGGTGGTGGTGCCCCACTGTATTCAGCGTGACTTTGGTGGAAAACTTTCT
HKI laA-259_5p GGGGGCGGTGGTGGTGCCCCACCGTTTTCAGCGTGACTTTGGTGGAAAACTTTCT
HK1 laA-89_3p GGGGCGGTGGTGGTGCCCCACTGTATTCAGCGTGACTTTGGTGGAAAACTTTCT

ContigB298549 GGGCGGGGGGCGGTGGTGGTGCCCCACTGTATTCAGCGTGACTTTGGTGGAAAACTTTCT
HK1 laA-173_5p T-GTGGGTTATGAAACCGTAGA
HK1 laA-147_5p GATCT-GTGGGTTATGAAACCGTAGA
HK1 1aA-184_5p AGAAATGGATCT-GTGGGTTATGAAACCGTAGA
HK1 laA-161_5p AATGGATCT-GTGGGTTATGAAACCGTAGA
HK1 laA-248_5p GTAGGGGGAGT-CCCAGGCGTAGACCAAGAAAAGGATCT-GTGGGTTATGAAACCGGAGA

Page 27 sur 136 HK1 laA-57_5p GTAGGTGGAGT-CCCAGGGGTAGACCAAGAAAAGGATCT-GTGGGTTATGAAACCGTAGA
HK1 laA-248_3p GTAGGTGGAGT-CCCAGGCGTAGACCAAGAAATGGATCT-GTGGGTTATGAAACCGTAGA
HK1 laA-260_3p GTAGGTGGAGT-CCCAGGCGTAGACCAAGAAATGGATCT-GTGGGTTATGAAACCGTAGA
HK1 laA-595p GTAGGTGGAGT-CCCAGGCGTAGACCAAGAAATGGATCT-GTGGGTTATGAAACCGTAGA
HK1 laA-573p GTAGGTGGAGT-CCCAGGCGTAGACCAAGAAATGGATCT-GTGGGTTATGAAACCGTAGA
HK1 laA-93_5p GTAGGTGGAGT-CCCAGGCGTAGACCAAGAAATGGATCT-GTGGGTTATGAAACCGTAGA
HK1 laA-273_3p GTAGGTGGAGT-CCCAGGCGTAGACCAAGAAATGGATCT-GTGGGTTATGAAACCGTAGA
HK1 laA-260_5p GTAGGTGGAGT-CCCAGGCGTGGACCAAGAAAAGGATCT-GTGGGTTATGAAACCGTAGA
HK1 laA-273_5p GTAGGTGGAGT-CCCAGGCGTAGACCAAGAAAAGGATCT-GTGGGTTATGAAACCGTAGA
HK1 laA-232_5p GTAGG
HK1 laA-226_5p T-CCCCGGGGTGGACCCAAAAAAGGACCT-TGGGGTTATGAAACCGAGAG
HK1 laA-274_5p TTAGGTGGAGTTCCCCGGCGTGGACCAAGAAAAGGATCCCTTGGGTTTTGAAACCGAGAG
HK1 laA-29_5p GTAGGTGGAGT-CCCAGGGGTAGACCAAAAAAAGGATCT-GGGGGTTATGAAACCGTAGA
HK1 laA-237_3p GTAGGTGGAGT-CCCAGGCGTAGACCAAGAAATGGATCT-GTGGGTTATGAAACCGTAGA
HK1 laA-256_3p GTAGGTGGAGT-CCCAGGCGTAGACCAAGAAATGGATCT-GTGGGTTATGAAACCGTAGA
HK1 1aA-69_3p GTAGGTGGAGT-CCCAGGCGTAAACCAAGAAATGGATCT-GTGGGTTATGAAACCGTAGA
HK1 laA-226_3p GTAGGTGGAGT-CCCAGGCGTAGACCAAGAAATGGATCT-GTGGGTTATGAAACCGTAGA
HK1 laA-249_3p GTAGGTGGAGT-CCCAGGCGTAGACCAAGAAATGGATCT-GTGGGTTATGAAACCGTAGA
HK1 laA-249_5p GTAGGTGGAGT-CCCAGGCGTAGACCAAGAAAAGGATCT-GTGGGTTATGAAACCGTAGA
HK1 laA-274_3p GTAGGTGGAGT-CCCAGGCGTAGACCAAGAAATGGATCT-GTGGGTTATGAAACCGTAGA
HK1 laA-259_3p GTAGGTGGAGT-CCCAGGCGTAGACCAAGAAATGGATCT-GTGGGTTATGAAACCGTAGA
HK1 laA-33_3p GTAGGTGGAGT-CCCAGGCGTAGACCAAGAAATGGATCT-GTGGGTTATGAAACCGTAAA
HK1 laA-93_3p GTAGGTGGAGT-CCCAGGCGTAAACCAAGAAATGGATCT-GTGGGTTATGAAACCGTAAA
HK1 laA-27_3p GTAGGTGGAGT-CCCAGGCGTAGACCAAGAAATGGATCT-GTGGGTTATGAAACCGTAAA
HK1 laA-6_3p GTAGGTGGAGT-CCCAGGCGTAAACCAAGAAATGGATCT-GTGGGTTATGAAACCGTAAA
HK1 laA-41_3p GTAGGTGGAGT-CCCAGGCGTAGACCAAGAAATGGATCT-GTGGGTTATGAAACCGTAAA
HK1 laA-87_3p GTAGGTGGAGT-CCCAGGCGTAAACCAAGAAATGGATCT-GTGGGTTATGAAACCGTAAA
HK1 laA-59_3p GTAGGTGGAGT-CCCAGGCGTAGACCAAGAAATGGATCT-GTGGGTTATGAAACCGTAAA
HK1 laA-29_3p GTAGGTGGAGT-CCCAGGCGTAGACCAAGAAATGGATCT-GTGGGTTATGAAACCGTAGA
HK1 laA-259_5p GTAGGTGGAGT-CCCAGGCGTAGACCAAGAAAAGGATCT-GTGGGTTATGAAACCGTAGA
HK1 laA-89_3p GTAGGTGGAGT-CCCAGGCGTAGACCAAGAAATGGATCT-GTGGGTTATGAAACCGTAGA
HK1 1aA-89_5p AGGCGTAGACCAAGAAATGGATCC-TTGGGTTATGAAACCGTAGA
HK1 laA-6_5p GAGT-CCCAGGCGTAGACCAAGAAATGGATCT-TTGGGTTATGAAACCGTAGA
HK1 laA-27_5p CCAGGCGTAGACCAAGAAATGGATCT-GTGGGTTATGAAACCGTAGA
HK1 laA-87_5p GCGTAGACCAAGAAATGGATCT-GTGGGTTATGAAACCGTAGA
HK1 laA-62_5p GACCAAGAAATGGATCT-GTGGGTTATGAAACCGTAGA

Contig8298549 GTAGGTGGAGT-CCCAGGCGTAGACCAAGAAATGGATCT-GTGGGTTATGAAACCGTAGA
HK1 laA-173_5p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA
HK1 laA-147_5p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA
HK1 laA-184_5p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA
HK1 laA-161_5p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA
HK1 laA-248_5p GGCCCTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA
HKl 1aA-57_5p GGCCTTTTGACGGTAATCACACCATTT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA
HK1 laA-248_3p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA
HK1 laA-260_3p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA
HK1 laA-59_5p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA
HK1 laA-57_3p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA
HK1 laA-93_5p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA
HK1 laA-256_5p GAGGGAAAA
HK1 laA-273_3p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA
HK1 laA-260_5p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA
HK1 laA-273_5p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA
HK1 laA-232_5p GGCCCTTTGATTGTAATCACACCACCT-GTGCCCACCTTGAATTGGGTGTTGAGGGAAAA
HK1 laA-226_5p GGCCTTTTGACGGGAATCACACCATCT-GTGCCCACTTTATATCTGGTGTCGAGGGAAAA
HK1 laA-274_5p GGCCCTTTGACGGTAATCACACCATCTTGTGCCCACTTTGAATCGGGTGTTGGGGGAAAA
HK1 laA-29_5p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA
HK1 laA-237_3p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA
HK1 laA-256_3p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA
HK1 laA-69_3p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTC
HK1 laA-226_3p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA
HK1 laA-249_3p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA

Page 28 sur 136 HK1 laA-249_5p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA
HK1 laA-2743p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCCAGGGAAAA
HK1 laA-2593p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA
HK1 laA-1713p GTCGAGGGAAAA
HK1 laA-99_5p GTCGAGGGAAAA
HK1 laA-993p GTCGAGGGAAAA
HKI laA-913p GTCGAGGGAAAA
HK1 laA-1013p GTCGAGGGAAAA
HKI laA-1715p GTCGAGGGAAAA
HKI laA-33_3p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA
HKI laA-93_3p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA
HK1 laA-273p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA
HKI laA-6_3p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA
HK1 laA-413p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCAGGTGTCGAGGGATAA
HK1 laA-873p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA
HK1 laA-59_3p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA
HK1 laA-293p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA
HK1 laA-259_5p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA
HK1 1aA-89_3p GGCCTTTTGACTGTAATCACACCATCT-GTGCAAACTTTAAATCGGGTGTCGAGGGAAAA
HKI laA-237_5p GAGGGAAAA
HKI laA-89_5p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA
HK1 laA-6_5p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA
HK1 laA-134_5p GTCGAGGGAAAA
HK1 laA-124_5p GCCCACTTTGAATCGGGTGTCGAGGGAAAA
HKI laA-41_5p ATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA
HK1 laA-27_5p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA
HK1 laA-915p GTCGAGGGAAAA
HK1 laA-87_5p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA
HK1 laA-62_5p GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTTGAGGGAAAA

Contig8298549 GGCCTTTTGACTGTAATCACACCATCT-GTGCCCACTTTGAATCGGGTGTCGAGGGAAAA
HK1 laA-173_5p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
HK1 laA-147_5p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
HK1 laA-184_5p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
HK1 laA-161_5p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
HK1 laA-248_5p ATAGGGTGTCCTTTGTCGACCGGGGCAATCTTCAAAAATCAATTTGCCCAGGACGGGGCC
HK1 laA-57_5p ATAGGGTGTCCTTTGTCGACCGGTGCAATTTTCAAAATTCACTTTGCCCAGGACGCGGCC
HK1 laA-248_3p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
HK1 laA-260_3p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
HK1 laA-59_5p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTTTGCCCAGGACGCGGCC
HK1 laA-57_3p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
HK1 laA-93_5p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTTTGCCCAGGACGCGGCC
HK1 laA-256_5p ATAGGGTGTCTATTTTTGACCGGTGCAATTTTCAAAATTCATTTTTTTCAGGACGCGGCC
HK1 laA-273_3p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
HK1 laA-260_5p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTTTGCCCAGGACGCGGCC
HK1 laA-273_5p ATAGGGTGTCCTTTGTCGACCGGGGCAATCTTCAAAATTCAATTTGCCCAGGACGCGGCC
HK1 laA-232_5p ATAGGATGTCATTTGTTGACGGGGGCAATTTTCAAAATTCATTTTTCTCAGGACGCGGCC
HK1 laA-226_5p ATAGGATGTCCTTTGTGGACCGGGGCAATTTTTAAAATTAATTTTGCCCAGGACGCGGCC
HKI laA-274_5p ATAGGGTGTCCTTTGTGGACCGGGGCAATTTTCAAAATTCAATTTGCCCAGGACGCGGCC
HK1 laA-29_5p AAAGGGTGTCCTTTGTTGACCGGGGCAATTTTCAAAATTCAATTTTCCCAGGACGGGGCC
HK1 laA-237_3p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
HK1 laA-256_3p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
HKI laA-226_3p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
HK1 laA-249_3p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
HK1 laA-249_5p ATAGGCTGTCCTTTGTCGACCGGTGCAATTTTCAAAATTCACTTTGCCCAGGACGCGGCC
HK1 laA-274_3p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
HK1 laA-259_3p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
HK1 laA-171_3p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
HK1 laA-99_5p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
HK1 laA-99_3p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
HK1 laA-91_3p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
HK1 laA-101_3p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC

Page 29 sur 136 HK1 laA-171_5p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
HK1 1aA-33_3p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
HK1 laA-93_3p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
HK1 1aA-27_3p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
HK1 1aA-6_3p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
HK1 laA-41_3p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGCCC
HK1 laA-87_3p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
HK1 laA-59_3p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
HK1 laA-29_3p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
HK1 laA-259_5p ATAGGCTGTCCTTTGTCGACCGGTGCAATTTTCAAAATTCACTTTGCCCAGGACGCGGCC
HK1 laA-89_3p ATAGGCTGTCCTTTGTCAACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
HK1 laA-237_5p ATAGGCTGTCCTTTGTCGACCGGGGCAATCTTCAAAATTCAATTTGCCCAGGACGCGGCC
HK1 laA-89_5p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTTTGCCCAGGACGCGGCC
HK1 laA-6_5p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
HK1 laA-134_5p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
HK1 laA-124_5p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
K1 laA-41_5p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
HK1 laA-27_5p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
HK1 1aA-91_5p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
HK1 laA-87_5p ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
HK1 laA-62__5p ATAGGCTGTCCTTTGTCGACCGGTGCAATTTTCAAAATTCACTCTGCCCAGGACGCGGCC

Contig8298549 ATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCC
HK1 laA-173_5p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTCGGCGTCAAAGCCAGGGTG
HK1 laA-147_5p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTCGGCGTCAAAGCCAGGGTG
HK1 1aA-184_5p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTCGGCGTCAAAGCCAGGGTG
HK1 laA-161_5p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTCGGCGTCAAAGCCAGGGTG
HK1 laA-248_5p TCTCTCCAGGTGGCGCCGGGGCACCGTGAAAGTGTAGCTCTTGGCGTCAAAGCCAGGGTG
HK1 laA-57_5p TCTCTCCAGGGGGGGCCGGGGCACCGTGAAA.GTGTAGCTCTTGGGGTCAAAGCCAGGGGG
HK1 laA-248_3p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTCGGCGTCAAAGCCAGGGTG
HK1 laA-260_3p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTCGGCGTCAAAGCCAGGGTG
HK1 laA-59_5p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTTGGCGTCAAAGCCAGGGTG
HK1 laA-57_3p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTCGGCGTCAAAGCCAGGGTG
HK1 laA-93_5p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTTGGCGTCAAAGCCAGGGTG
HK1 laA-256_5p TCTTTCCAAGTGGCGCCGGGGCCCCGTGAACGGGTAGCTCTTGGCGTCAAAGCCAGGGTG
HK1 laA-273_3p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTCGGCGTCAAAGCCAGGGTG
HK1 laA-260_5p TCTCTCCAGGTGGGGCCGGGGCACCGTGAAAGTGTAGCTCTTGGCGTCAAAGCCAGGGTG
HK1 laA-273_5p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTTGGGGTCAAAGCCAGGGGG
HK1 laA-232_5p TCTTTCCAGGTGGCGCCGGGGCACCGTGAAAGTGTAGCTCTTGGGGTCAAAACCAGGGTG
HK1 1aA-226_5p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTTGGGGTCAAAACCAGGGTG
HK1 1aA-274_5p TCTTTCCAGGTGGGGCCGGGGCACCGTGAACGTGTAGCTCTTGGGGTCAAAGCCAGGGTG
HK1 laA-29_5p TCTCTCCAGGGGGGGCCGGGGCACCGTGAACGTGTAGCTCTTGGGGTCAAAGCCAGGGGG
HK1 1aA-237_3p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTCGGCGTCAAAGCCAGGGTG
HK1 1aA-256_3p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTCGGCGTCAAAGCCAGGGTG
HK1 laA-226_3p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTCGGCGTCAAAGCCAGGGTG
HK1 laA-249_3p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTCGGCGTCAAAGCCP.GGGTG
HK1 laA-249_5p TCTCTCCAGGTGGGGCCGGGGCACCGTGAAAGTGTAGCTCTTGGCGTCAAAGCCAGGGTG
HK1 laA-274_3p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTCGGCGTCAAAGCCAGGGTG
HK1 laA-259_3p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTCGGCGTCAAAGCCAGGGTG
HK1 laA-171_3p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTCGGCGTCAAAGCCAGGGTG
HK1 laA-99_-5p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTCGGCGTCAAAGCCAGGGTG
HK1 laA-99_3p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTCGGCGTCAAAGCCAGGGTG
HK1 laA-91_3p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTCGGCGTCAAAGCCAGGGTG
HK1 laA-101_3p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTCGGCGTCAAAGCCAGGGTG
HK1 1aA-171_5p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTCGGCGTCAAAGCCAGGGTG
HK1 laA-33_3p TCTCTCCAGGTGGCGCCGGGNCACCGTGAACGTGTAGCTCTCGACGTCNAAGCCAGGGTG
HK1 laA-93_3p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTCGGCGTCAAAGCCAGGGTG
HK1 laA-27_3p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTCGGCGTCAAAGCCAGGGTG
HK1 laA-6_3p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTCGGCGTCAAAGCCAGGGTG
HK1 laA-41_3p TCTCTCCAAGTGGC
HK1 laA-87_3p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTCGGCGTCAAAGCCAGGGTG
HK1 laA-59_3p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTCGGCGTCAAAGCCAGGGTG

Page 30 sur 136 HK1 laA-29_3p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTCGGCGTCAAAGCCAGGGTG
HK1 1aA-259_5p TCTCTCCAGGTGGGGCCGGGGCACCGTGAACGTGTAGCTCTTGGCGTCAAAGCCAGGGTG
HK1 laA-89_3p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAACTCTCGGCGTCAAA
HK1 1aA-237_5p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTTGGCGTCAAAGCCAGGGTG
HK1 1aA-89_5p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTCGGCGTCAAAGCCAGGGTG
HK1 laA-6_5p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTCGGCGTCAAAGCCAGGGTG
HK1 laA-134_5p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTCGGCGTCAAAGCCAGGGTG
HK1 laA-124_5p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTCGGCGTCAAAGCCAGGGTG
HK1 1aA-41_5p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTTGGCGTCAAAGCCAGGGTG
HK1 laA-27_5p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTTGGCGTCAAAGCCAGGGTG
HK1 laA-91_5p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTTGGCGTCAAAGCCAGGGTG
HK1 laA-87_5p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTCGGCGTCAAAGCCAGGGTG
HK1 laA-33_5p GTAGCTCTCGGCGTCAAAGCCAGGGTG
HK1 laA-62_5p TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTTGGCGTCAAAGCCAGGGTG

Contig8298549 TCTCTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTCGGCGTCAAAGCCAGGGTG
HK1 laA-173_5p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-147_5p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-184_5p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-161_5p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-248_5p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-57_5p GCAGGGCTCCGGGTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-248_3p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-260_3p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-59_5p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-57_3p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCANCAGCAGCAGCGCCGA
HK1 laA-93_5p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-256_5p GCAGGGCTCCGGCTCCTGGCAGAGCCCAGAGGAGACCTGCAGCAACAGCAGCAGCGCCCA
HK1 laA-273_3p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-260_5p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-273_5p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-232_5p GCAGGGCTCCGGTTCCTGGCAGAGCCAAGAGGAGACATGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-226_5p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 1aA-274_5p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-29_5p GCAGGGCTCCGGGTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 1aA-237_3p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 1aA-256_3p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 1aA-226_3p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 1aA-249_3p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 1aA-249_5p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 1aA-274_3p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 1aA-259_3p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-171_3p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-995p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-99_3p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 1aA-91_3p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-101_3p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-171_5p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 1aA-33_3p GCAGGGCTCCGGCTCCTGGCAGAGCCTAGAGGAGACCTG
HK1 laA-93_3p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-27_3p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-6_3p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-87_3p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-59_3p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-29_3p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-259_5p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-237_5p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-89_5p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-6_5p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-134_5p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-124_5p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-41_5p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA

Page 31 sur 136 HK1 laA-27_5p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-91_5p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-87_5p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-33_5p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-62_5p GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA

Contig8298549 GCAGGGCTCCGGCTCCTGGCAGAGCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGA
HK1 laA-173_5p GAGGCTGCGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAGGCGCCGG
HK1 laA-147_5p GAGGCTGCGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAGGCGCCGG
HK1 1aA-184_5p GAGGCTGCGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAGGCGCCGG
HK1 laA-161_5p GAGGCTGCGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAGGCGCCGG
HK1 laA-248_5p GAGGGTGGGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAGGCGCCGG
HK1 laA-57_5p GAGGGTGGGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAGGCGCCGG
HK1 1aA-248_3p GAGGCTGCGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAGGCGCCGG
HK1 laA-260_3p GAGGCTGCGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAGGCGCCGG
HK1 laA-59_5p GAGGCTGCGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAGGCGCCGG
HK1 laA-57_3p GAGGCTGCGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAGGCGCCGG
HK1 laA-93_5p GAGGCTGCGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAGGCGCCGG
HK1 laA-256_5p GAGGCTGGGGCTCCAAGGGCCC
HK1 laA-273_3p GAGGCTGCGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAGGCGCCGG
HK1 1aA-260_5p GAGGGTGGGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAGGCGCCGG
HK1 laA-273_5p GAGGGTGGGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAGGCGCCGG
HK1 laA-232_5p GAGGATGGGGCTCCAAGGGCCCA
HK1 1aA-226_5p GAGGGTGGGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAGGCGCCGG
HK1 laA-274._5p GAGGGTGGGGCTCCAAGGGCCCCTGGCTGGCCGGGGACGCCGAGCAAGGGCAGGCGCCGG
HK1 laA-29_5p GAGGGTGGGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAGGGGCCGG
HK1 laA-237_3p GAGGCTGCGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAGGCGCCGG
HK1 laA-256_3p GAGGCTGCGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAGGCGCCGG
HK1 laA-226_3p GAGGCTGCGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAAGCCCCGG
HK1 laA-249_3p GAGGCTGCGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAGGCGCCGG
HK1 laA-249_5p GAGGGTGGGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAGGCGCCGG
HK1 laA-274_3p GAGGCTGCGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAGGCGCCGG
HK1 laA-259._3p GAGGCTGCGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAGGCGCCGG
HK1 laA-171_3p CAGGCTGCGGCT
HK1 laA-99_5p GAGGCTGCGGCT
HK1 laA-99_3p GAGGCTGCGGCT
HK1 laA-91_3p GAGGCTGCGGCT
HK1 laA-101_3p GAGGCTGCGGCT
HK1 laA-171_5p GAGGCTGCGGCT
HK1 laA-93_3p GAGGCTGCGGCTCCAA
HK1 laA-27_3p GAGGCTGCGGCTCCAAGGGCCC
HK1 laA-6_3p GAGGCTGCGGCTCCAAGGGCCCATGGCTGGCCGGG
HK1 laA-87_3p GAGGCTGCGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCG
HK1 laA-59_3p GAGGCTGCGGCTCCAAGGGCCCATGGCTGGCCG
HK1 laA-29_3p GAGGCTGCGGCTCCAAGGGCCCATGGCTGGCCGGGGACACCGAGCGAGGGCAGGCGCCGG
HK1 laA-259Sp GAGGGTGCGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAGGCGCCGG
HK1 laA-2375p GAGGGTGGGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAGGCGCCGG
HK1 laA-89_5p GAGGCTGCGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAGGCGCCGG
HK1 laA-6_sp GAGGCTGCGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAGGCGCCGG
HK1 laA-134_5p GAGGCTGCGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAGGCGCCGG
HK1 laA-124_5p GAGGCTGCGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAGGCGCCGG
HK1 laA-41_Sp GAGGCTGCGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAGGCGCCGG
HK1 laA-27_5p GAGGCTGCGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAGGCGCCGG
HK1 laA-91_5p GAGGCTGCGGCT
HK1 laA-87_5p GAGGCTGCGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAGGCGCCGG
HK1 laA-33_5p GAGGCTGCGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAGGCGCCGG
HK1 laA-62_5p GAGGCTGCGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAGGCGCCGG

Contig8298549 GAGGCTGCGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCGAGCGAGGGCAGGCGCCGG
HK1 laA-173_5p GTGCGGTCGGGTCGGG-CCGGGCTGGAGCGGGCTGGAGTC-TGAACTGACTTCCGCAAGC

Page 32 sur 136 HKI laA-147_5p GTGCGGTCGGGTCGGG-CCGGGCTGGAGCGGGCTGGAGTC-TGAACTGACTTCCGCAAGC
HK1 laA-184_5p GTGCGGTCGGGTCGGG-CCGGGCTGGAGCGGGCTGGAGTC-TGAACTGACTTCCGCAAGC
HK1 laA-1615p GTGCGGTCGGGTCGGG-CCGGGCTGGAGCGGGCTGGAGTC-TGAACTGACTTCCGCAAGC
HK1 laA-248_5p GTGCGGTCGGGTCGGG-CCGGGCGGGAGCGGGGGGAGGTG-TGAAATGAATTCCGCAAGC
HK1 laA-57_5p GTGCGGTCGGGTCGGG-CCGGGCTGGAGCGGGGGGGAGTG-TGAAATGAATTCCGCAAGC
HK1 laA-248_3p GTGCGGTCGGGTCGGG-CCGGGCTGGAGCGGGCTGGAGTC-TGAACTGACTTCCG
HK1 laA-260_3p GTGCGGTCGGGTCGGG-CCGGGCTGGAGCGGGCTGGAGTC-TGA
HK1 laA-59_5p GTGCGGTCGGGTCGGG-CCGGGCTGGAGCGGGCTGGAGTT-TGA
HK1 laA-57_3p GTGCGGTCGGGTCGGG-CCGGGCTGGAACGGGCTGGAATC-TGAACTGACTTCCGCAA
HK1 laA-93_5p GTGCGGTCGGGTCGGG-CCGGGCTGGAGCGGGCTGGAGTT-TGA
HK1 laA-273_3p GTGCGGTCGGGTCGGG-CCGGGCTGGAGCGGGCTGGAGTC-TGAACTGACTTCCGCAA
HK1 laA-260_5p GTGCGGTCGGGTCGGG-CCGGGCTGGAGCGGGCTGGAGTT-TGA
HK1 laA-273_5p GGGCGGTCGGGTCGGG-CCGGGCTGGAGCGGGGGGGGGTG-TGAAGTGAATTCCGCAAGC
HK1 1aA-226_5p GGGCGTCGGGGTCGGGGCCGGGCCGCACGGGGCGGGGGTGGTGAAATGAATTCCGCAAGC
HK1 laA-274_5p GGG-GGTCGGGTCGGGGCCGGGCCG
HK1 laA-29_5p GGGCGGTCGGGTCGGG-CCGGGCTGGAGCGGGGGGGAGTG-TGAAATGAAATCCGCAAGC
HK1 laA-237_3p GTGCGGTCGGGTCGGG-CCGGGCTGGAGCGGGCTGGAGTC-T
HK1 laA-256_3p GTGCGGTCGGGTCGGG-CCGGGCTGGAACGG
HK1 laA-226_3p GTGCGGTCGGGTCAGG-CCGGGC
HK1 laA-249_3p GTGCGGTCGGGTCGGG-CCGGGCTGGAGCGGGCTGGAGTC-T
HK1 laA-249_5p GTGCGGTCGGGTCGGG-CCGGGCTGGAGCGGGCGGGAGTT
HK1 laA-274_3p GTGCGGTCGGGTCGGG-CCGGGCTGGAGCG
HK1 laA-259_3p GTGCGGTCGGGTCGGG-CCGGGCTGGAGCGGGCTGGATTC-TGAACTGACTTC
HK1 laA-29_3p GTGCGGTCGGGTCAGG-CCAGGCTGGAACGGGCTGGA
HK1 laA-259_5p GTGCGGTCGGGTCGGG-CCGGGCTGGAGCGGGCGGGAGTC-TGAAATGACTTCCGCAAGC
HK1 laA-237_5p GTGCGGTCGGGTCGGG-CCGGGCTGGAGCGGGGGGGAGTT-TGAAATGACTTCCGCAAGC
HK1 laA-89_5p GTGCGGTCGGGTCGGG-CCGGGCTGGAGCGGGCTGGAGTT-TGAAAAGACTTCCGCAAGG
HK1 laA-6_5p GTGCGGTCGGGTCGGG-CCGGGCTGGAGCGGGCTGGAGTC-TGAACTGACTTCCGCAAGC
HK1 laA-134_5p GTGCGGTCGGGTCGGG-CCGGGCTGGAGCGGGCTGGAGTC-TGAACTGACTTCCGCAAGC
HK1 laA-124_5p GTGCGGTCGGGTCGGG-CCGGGCTGGAGCGGGCTGGAGTC-TGAACTGACTTCCGC
HK1 laA-41_5p GTGCGGTCGGGTCGGG-CCGGGCTGGAGCGGGCTGGAGTC-TGAAATGACTTCCGCAAGC
HK1 laA-27_5p GTGCGGTCGGGTCGGG-CCGGGCTGGAGCGGGCTGGAGTT-TGAACTGACTTCCGCAAGC
HK1 laA-87_5p GTGCGGTCGGGTCGGG-CCGGGCTGGAGCGGGCTGGAGTT-TGAACTGACTTCCGCAAGC
HK1 laA-33_5p GTGCGGTCGGGTCGGG-CCGGGCTGGAGCGGGCTGGAGTT-TGAACTGACTTCCGCAAGC
HK1 laA-62_5p GTGCGGTCGGGTCGGG-CCGGGCTGGAGCGGGCTGGAGTC-TGAAATGACTTCCGCAAGC

Contig8298549 GTGCGGTCGGGTCGGG-CCGGGCTGGAGCGGGCTGGAGTC-TGAACTGACTTCCGCAAGC
HK1 laA-173_5p TCACAGGTGCTTTGCAGTTC
HK1 laA-147_5p TCACAGGTGCTTTGCAGTTC
HK1 laA-184_5p TCACAGGTGCTTTGCAGTTC
HK1 laA-161_5p TCACAGGTGCTTTGCAG
HK1 laA-248_5p TCACAGGTGCT
HKI laA-57_5p TCACAG
HK1 laA-273_5p TCACAGGTGCTTTGCAGTTCTTT
HK1 laA-226_5p TCACCCGTGCTTTGCAG
HK1 laA-29_5p TCACAGGTGCTTTG
HKI laA-259_5p TCACAGGTGCTTTGCAGTTC
HKI laA-237_5p TCACAGGTGCTTTGCAG
HK1 laA-89_5p TCACAGTCGCTTAGCAG
HK1 laA-6_5p TCACAGGTGCTTTG
HK1 laA-134_5p TCACAGGTGCT
HKI laA-41_5p TCACAG
HK1 laA-27_5p TCACAGGTGCT
HK1 laA-87_5p TCACAGGTGCTTTGCAGTTT
HK1 laA-33_5p TCACAGGTGCTTTGCAGTTT
HK1 laA-62_5p TCACAGGTGCTTAGCAGTTT

Contig8298549 TCACAGGTGCTTTGCAGTTCTTT

Page 33 sur 136 Contig8298549 Consensus sequence >Contig8298549 498 nt GGGCGGGGGGCGGTGGTGGTGCCCCACTGTATTCAGCGTGACTTTGGTGGAAAACTTTCTGTAGGTGGAGTCCCAGGCG
T
AGACCAAGAAATGGATCTGTGGGTTATGAAACCGTAGAGGCCTTTTGACTGTAATCACACCATCTGTGCCCACTTTGAA
T
CGGGTGTCGAGGGAAAAATAGGCTGTCCTTTGTCGACCGGTGCAATCTTCAAAATTCACTCTGCCCAGGACGCGGCCTC
T
CTCCAGGTGGCGCCGGGGCACCGTGAACGTGTAGCTCTCGGCGTCAAAGCCAGGGTGGCAGGGCTCCGGCTCCTGGCAG
A
GCCAAGAGGAGACCTGCAGCAGCAGCAGCAGCGCCGAGAGGCTGCGGCTCCAAGGGCCCATGGCTGGCCGGGGACGCCG
A
GCGAGGGCAGGCGCCGGGTGCGGTCGGGTCGGGCCGGGCTGGAGCGGGCTGGAGTCTGAACTGACTTCCGCAAGCTCAC
A
GGTGCTTTGCAGTTCTTT

back to table Contig8298584 Alignment HK1 laA-58_3p GTGGTAACCTAGGTATTGTGCTTGTTGAGCCATTTAATTTTCCTCACCTTCCGATTCGGA
HK1 laA-82_3p GTGGTAACCTAGGTATTGTGCTTGTTGAGCCATTTAATTTTCCTCACCTTCCGATTCGGA

Contig8298584 GTGGTAACCTAGGTATTGTGCTTGTTGAGCCATTTAATTTTCCTCACCTTCCGATTCGGA
HK1 laA-58_3p TTCTTCTTCTGCATTTTGTAACCACTCAACAAATTTCTTCATCTGGTCAAGAAAAACACT
HK1 laA-82_3p TTCTTCTTCTGCATTTTGTAACCACTCAACAAATTTCTTCATCTGGTCAAGAAAAACACT

Contig8298584 TTCTTCTTCTGCATTTTGTAACCACTCAACAAATTTCTTCATCTGGTCAAGAAAAACACT
HK1 laA-58_3p TTTGCCTTTAGCAACATGTGCTTCCTTATACCATTTCAGTATTGCTTCTTCGCTCAGAAC
HK1 laA-82_3p TTTGCCTTTAGCAACATGTGCTTCCTTATACCATTTCAGTATTGCTTCTTCGCTCAGAAC

Contig8298584 TTTGCCTTTAGCAACATGTGCTTCCTTATACCATTTCAGTATTGCTTCTTCGCTCAGAAC
HK1 laA-58_3p ATCAGCTTTATAAAAGAGAACCACAATCTTCTGAAAGGCTTTCATGAAATGGATGTTGTC
HK1 laA-82_3p ATCAGCTTTATAAAAGAGAACCACAATCTTCTGAAAGGCTTTCATGAAATGGATGTTGTC

Contig8298584 ATCAGCTTTATAAAAGAGAACCACAATCTTCTGAAAGGCTTTCATGAAATGGATGTTGTC
HK1 laA-58_3p GTAGCAGTATTCCTGAACCTTCTGGAGGAGGATCAGCTCTGACTGGCCTTGGGAGCTGAA
HK1 laA-82_3p GTAGCAGTATTCCTGAACCTTCTGGAGGAGGATCAGCTCTGACTGGCCTTGGGAGCTGAA

Contig8298584 GTAGCAGTATTCCTGAACCTTCTGGAGGAGGATCAGCTCTGACTGGCCTTGGGAGCTGAA
HK1 laA-58_3p CACGGCCAGCAGGGGAGCATATTGCTTCAGGTGCTTCAGAGCCTGCTCTGCAACAAGTTC
HK1 laA-82_3p CACGGCCAGCAGGGGAGCATATTGCTTCAGGTGCTTCAGAGCCTGCTCTGCAACAAGTTC

Contig8298584 CACGGCCAGCAGGGGAGCATATTGCTTCAGGTGCTTCAGAGCCTGCTCTGCAACAAGTTC
HKl laA-58_3p TTCCTTCTTGTTCCACTCA
HK1 laA-82_3p TTCCTTCTTGTTCCACTCAACAGCGTTCATTATACATGTCCACAGAAGACCAATCACTGC

Contig8298584 TTCCTTCTTGTTCCACTCAACAGCGTTCATTATACATGTCCACAGAAGACCAATCACTGC
HK1 laA-82_3p TGTTTCTGGAAGATCATTCCTCTTCATTTN

Page 34 sur 136 ContigB298584 TGTTTCTGGAAGATCATTCCTCTTCATTTN

Contig8298584 Consensus sequence >Contig8298584 450 nt GTGGTAACCTAGGTATTGTGCTTGTTGAGCCATTTAATTTTCCTCACCTTCCGATTCGGATTCTTCTTCTGCATTTTGT
A
ACCACTCAACAAATTTCTTCATCTGGTCAAGAAAAACACTTTTGCCTTTAGCAACATGTGCTTCCTTATACCATTTCAG
T
ATTGCTTCTTCGCTCAGAACATCAGCTTTATAAAAGAGAACCACAATCTTCTGAAAGGCTTTCATGAAATGGATGTTGT
C
GTAGCAGTATTCCTGAACCTTCTGGAGGAGGATCAGCTCTGACTGGCCTTGGGAGCTGAACACGGCCAGCAGGGGAGCA
T
ATTGCTTCAGGTGCTTCAGAGCCTGCTCTGCAACAAGTTCTTCCTTCTTGTTCCACTCAACAGCGTTCATTATACATGT
C
CACAGAAGACCAATCACTGCTGTTTCTGGAAGATCATTCCTCTTCATTTN

back to table Contig8298587 Alignment HK1 laA-236_3p GCGCCCGAAATCACACTCCTNNACCCTCTTCTCCCGNGNNAGACGCAAACCATCCCCCAG

Contig8298587 GCGCCCGAAATCACACTCCTNNACCCTCTTCTCCCGNGNNAGACGCAAACCATCCCCCAG
HK1 1aA-236_3p AACCCGACGCTGATGTTCTCGTTGCAGCCTTCTCCCCATATCTCAATAATGACAGAGGAG

Contig8298587 AACCCGACGCTGATGTTCTCGTTGCAGCCTTCTCCCCATATCTCAATAATGACAGAGGAG
HK1 laA-236_3p ACAGCTCTAGGAGCCGATTCAGACGTCTCTGCAGCTGTAGGAGTATAGGAAGCGCGCACA

Contig8298587 ACAGCTCTAGGAGCCGATTCAGACGTCTCTGCAGCTGTAGGAGTATAGGAAGCGCGCACA
HK1 laA-236_3p GAAGGAGGCCAAGAGCTATGAGGCTGACTGTATGGCTGCACTCCCGGCTAACGATTTTTT

Contig8298587 GAAGGAGGCCAAGAGCTATGAGGCTGACTGTATGGCTGCACTCCCGGCTAACGATTTTTT
HK1 laA-236_3p TTTGAGACAGGCGGCGGATCAGACAAACAGCCAGGAGCAGCNGGNNGNGNAGNGGGGGGA

Contig8298587 TTTGAGACAGGCGGCGGATCAGACAAACAGCCAGGAGCAGCNGGNNGNGNAGNGGGGGGA
HK1 laA-236_3p AAACACAGCCAAGATAGCCCTCCNGGAAGAGGCGCGGAGGCGCAAGGAGGAAAAAAAAGA

ContigB298587 AAACACAGCCAAGATAGCCCTCCNGGAAGAGGCGCGGAGGCGCAAGGAGGAAAAAAAAGA
HK1 laA-236_3p AGAGGNGCAGCACAGGGCCAAAGAAGCCCAGGATGACNNGGTAAGACCAAGGAGGAGNTG

Contig8298587 AGAGGNGCAGCACAGGGCCAAAGAAGCCCAGGATGACNNGGTAAGACCAAGGAGGAGNTG
HK1 laA-236_3p CACNNGGNGANNANAGNANNNCNGCCCCCACCACCCCCCTG

Contig8298587 CACNNGGNGANNANAGNANNNCNGCCCCCACCACCCCCCTG

Page 35 sur 136 Contig8298587 Consensus sequence >Contig8298587 461 nt GCGCCCGAAATCACACTCCTNNACCCTCTTCTCCCGNGNNAGACGCAAACCATCCCCCAGAACCCGACGCTGATGTTCT
C
GTTGCAGCCTTCTCCCCATATCTCAATAATGACAGAGGAGACAGCTCTAGGAGCCGATTCAGACGTCTCTGCAGCTGTA
G
GAGTATAGGAAGCGCGCACAGAAGGAGGCCAAGAGCTATGAGGCTGACTGTATGGCTGCACTCCCGGCTAACGATTTTT
T
TTTGAGACAGGCGGCGGATCAGACAAACAGCCAGGAGCAGCNGGNNGNGNAGNGGGGGGAAAACACAGCCAAGATAGCC
C
TCCNGGAAGAGGCGCGGAGGCGCAAGGAGGAAAP.AAAAGAAGAGGNGCAGCACAGGGCCAAAGAAGCCCAGGATGACN
NG
GTAAGACCAAGGAGGAGNTGCACNNGGNGANNANAGNANNNCNGCCCCCACCACCCCCCTG
back to table Contig8298589 Alignment HK1 laA-150_5p CGGCGGGGGAGGCTGCTGCACCTGTGGTTGCTGCTGCTGCTGCTGCTGCTGGGGGGGTTG
HK1 laA-243_5p CGGCGGGGGAGGCTGCTGCACCTGTGGTTGCTGCTGCTGCTGCTGCTGCTGGGGGGGTTG

Contig8298589 CGGCGGGGGAGGCTGCTGCACCTGTGGTTGCTGCTGCTGCTGCTGCTGCTGGGGGGGTTG
HK1 laA-150_5p CTGAGGGCCCATCGCCATCGTGGCTTGTGCTGGGGTTGGGGAGCT-CAGCGACGCTGAGG
HK1 laA-243_5p CTGACGCCCCATCCCCATCGTGGCTTGTGCTGGGGTTGGGCACCTACACCGACCCTGAGG

Contig8298589 CTGACGCCCCATCCCCATCGTGGCTTGTGCTGGGGTTGGGCACCTACACCGACCCTGAGG
HK1 laA-150_5p ACGGTTTATTTGGTAATCCAGAAGTGGGGAGGCCAGGGGAAGGAACAGTTGTGCTGGGCA
HK1 laA-243_5p ACGGTTTATTTGGTAAACCAAAAGTGGGGAGGCCAGGGAAAAGAACAGTTGTGCTGGGCN

Contig8298589 ACGGTTTATTTGGTAAACCAAAAGTGGGGAGGCCAGGGAAAAGAACAGTTGTGCTGGGCA
HK1 1aA-150_5p GACCCATCAAGTTCGGCTTAGGAGACGTTAAAGCTGTGTTGGATGGAGTAAAGCCTGGCA
HK1 laA-243_5p NACCCNTCNNNTTCNCCTTAAGAAACTTTAAAGCTGTGTTGAATGGAGTAAAGCCCGGCA

Contig8298589 GACCCATCAAGTTCGCCTTAAGAAACGTTAAAGCTGTGTTGAATGGAGTAAAGCCCGGCA
HK1 laA-150_5p AGGA
HK1 1aA-243_5p AGGANGGCCNNNNNANGCCCNNNACCAACNCNNGAGGANTGCCCNGGNNCGCTGAAAATG

Contig8298589 AGGANGGCCNNNNNANGCCCNNNACCAACNCNNGAGGANTGCCCNGGNNCGCTGAAAATG
HK1 laA-243_5p CCAGAGGAAAGTTAAGGGCCAGAAAAGNGTTCTTCNCACACACCCCTGTGCCGNGGAGCT

Contig8298589 CCAGAGGAAAGTTAAGGGCCAGAAAAGNGTTCTTCNCACACACCCCTGTGCCGNGGAGCT
HK1 1aA-243_5p GCACATGCNAGGAACTTCGTTGGACATTATGATNCNATCAAACGGGTAAGAAGACAGGAG

Contig8298589 GCACATGCNAGGAACTTCGTTGGACATTATGATNCNATCAAACGGGTAAGAAGACAGGAG
HK1 laA-243_5p AGAGAGAAGTGAAAAAAGCACAAAAGAAAAATAAACAAAGAAGAAAGGAAAAAGTGAAAG

Contig8298589 AGAGAGAAGTGAAAAAAGCACAAAAGAAAAATAAACAAAGAAGAAAGGAAAAAGTGAAAG
HK1 laA-243_5p AACNAAGAGTACACAAGAGAAAAAGAGACAATAGTCG

Page 36 sur 136 Contig8298589 AACNAAGAGTACACAAGAGAAAAAGAGACAATAGTCG

Contig8298589 Consensus sequence >Contig8298589 517 nt CGGCGGGGGAGGCTGCTGCACCTGTGGTTGCTGCTGCTGCTGCTGCTGCTGGGGGGGTTGCTGACGCCCCATCCCCATC
G
TGGCTTGTGCTGGGGTTGGGCACCTACACCGACCCTGAGGACGGTTTATTTGGTAAACCAAAAGTGGGGAGGCCAGGGA
A
AAGAACAGTTGTGCTGGGCAGACCCATCAAGTTCGCCTTAAGAAACGTTAAAGCTGTGTTGAATGGAGTAAAGCCCGGC
A
AGGANGGCCNNNNNANGCCCNNNACCAACNCNNGAGGANTGCCCNGGNNCGCTGAAAATGCCAGAGGAAAGTTAAGGGC
C
AGAAAAGNGTTCTTCNCACACACCCCTGTGCCGNGGAGCTGCACATGCNAGGAACTTCGTTGGACATTATGATNCNATC
A
AACGGGTAAGAAGACAGGAGAGAGAGAAGTGAAAAAAGCACAAAAGAAAAATAAACAAAGAAGAAAGGAAAAAGTGAAA
G
AACNAAGAGTACACAAGAGAAAAAGAGACAATAGTCG

back to table Contig8298592 Alignment HK1 laA-136_3p ATGGTTCGATATCTCCCCCCNCCCCCCCCNTCCCCTGGGCTCNTCGTGTCCGCCCGCGGG

Contig8298592 ATGGTTCGATATCTCCCCCCNCCCCCCCCNTCCCCTGGGCTCNTCGTGTCCGCCCGCGGG
HK1 1aA-136_3p NNCGTCCCCCCCCCCCCCCGCTANGTTCNTTCTCCCNCCCGTCCCCCNNTGTCGNNNTTT

Contig8298592 NNCGTCCCCCCCCCCCCCCGCTANGTTCNTTCTCCCNCCCGTCCCCCNNTGTCGNNNTTT
HK1 laA-136_3p NNTCCCCCNNNCTTCCNNCTCTCNNTCCTCCCCCCCCCGGNNCCACNTTCACCCCNNNAA

Contig8298592 NNTCCCCCNNNCTTCCNNCTCTCNNTCCTCCCCCCCCCGGNNCCACNTTCACCCCNNNAA
HK1 laA-136_3p TTTTAATTTTGCTCTGGCCCGCCCGCCCCCTNNNNNNTGTAGCTTTTTACTTTCCAGCAC

Contig8298592 TTTTAATTTTGCTCTGGCCCGCCCGCCCCCTNNNNNNTGTAGCTTTTTACTTTCCAGCAC
HK1 1aA-136_3p ATCCACCAAGNNCNNCACAAGCAGCCATCGCCTCATCCTCCGGGCGGGGGGGCTTGAACA

Contig8298592 ATCCACCAAGNNCNNCACAAGCAGCCATCGCCTCATCCTCCGGGCGGGGGGGCTTGAACA
HK1 laA-136_3p GTGGAGAACCCGTGGTTGCGCTTAAAAAGGGCTTGATGCGCAAAAP.AATGCTCTCTCATG

Contig8298592 GTGGAGAACCCGTGGTTGCGCTTAAAAAGGGCTTGATGCGCAAAAAAATGCTCTCTCATG
HK1 laA-136_3p TTCTGTTTCCATGAACACAGCCACACTTCCAAAAAAGTGTGTANAGATATATATGTGCAC

Contig8298592 TTCTGTTTCCATGAACACAGCCACACTTCCAAAAAAGTGTGTANAGATATATATGTGCAC
HK1 laA-136_3p ACACACACACAGGCACACACTTGGGAACCATA

Contig8298592 ACACACACACAGGCACACACTTGGGAACCATA

Page 37 sur 136 <<

Contig8298592 Consensus sequence >Contig8298592 452 nt ATGGTTCGATATCTCCCCCCNCCCCCCCCNTCCCCTGGGCTCNTCGTGTCCGCCCGCGGGNNCGTCCCCCCCCCCCCCC
G
CTANGTTCNTTCTCCCNCCCGTCCCCCNNTGTCGNNNTTTNNTCCCCCNNNCTTCCNNCTCTCNNTCCTCCCCCCCCCG
G
NNCCACNTTCACCCCNNNAATTTTAATTTTGCTCTGGCCCGCCCGCCCCCTNNNNNNTGTAGCTTTTTACTTTCCAGCA
C
ATCCACCAAGNNCNNCACAAGCAGCCATCGCCTCATCCTCCGGGCGGGGGGGCTTGAACAGTGGAGAACCCGTGGTTGC
G
CTTAAAAAGGGCTTGATGCGCAAAAAAATGCTCTCTCATGTTCTGTTTCCATGAACACAGCCACACTTCCAAAAAAGTG
T
GTANAGATATATATGTGCACACACACACACAGGCACACACTTGGGAACCATA
back to table ~
Contig8298594 Alignment HK1 laA-276_3p TCTCTGCAGGTAAGCGGTATAGAAGGACCTGGATTCCATGAGCACGGGGACTCGGGAGAC
HK1 laA-264_3p CGGGGACTCGGGAGAC
HK1 laA-263_3p CGGGGACTCGGGAGAC

Contig8298594 TCTCTGCAGGTAAGCGGTATAGAAGGACCTGGATTCCATGAGCACGGGGACTCGGGAGAC
HK1 laA-276_3p ATAGCCATTCCGGAACAGCAGGTAGCAAGAGGGGAAGTCGGTGACACCAAACTTTCTCAC
HK1 1aA-264_3p AGAGCCATTCCGGAACAGCAGGTAGCAAGAGGGGAAGTCGGTGACACCAAACTTTCTCAC
HK1 laA-263_3p AGAGCCATTCCGGAACAGCAGGTAGCAAGAGGGGAAGTCGGTGACACCAAACTTTCTCAC

Contig8298594 AGAGCCATTCCGGAACAGCAGGTAGCAAGAGGGGAAGTCGGTGACACCAAACTTTCTCAC
HK1 laA-276_3p CACATTGGCCTCTGTGTTCAGCACCCTGCGCACCGCCACGCCTTTGTGCTGGGACAGGTC
HK1 laA-264_3p CACATTGGCCTCTGTGTTCAGCACCCTGCGCACCGCCACGCCTTTGTGCTGGGACAGGTC
HK1 laA-263_3p CACATTGGCCTCTGTGTTCAGCACCCTGCGCACCGCCACGCCTTTGTGCTGGGACAGGTC

Contig8298594 CACATTGGCCTCTGTGTTCAGCACCCTGCGCACCGCCACGCCTTTGTGCTGGGACAGGTC
HK1 laA-276_3p CAAAGCCACCTCTCTACCCAGGTAGGAGCCTCCCTTTTAAAAAATCAGAGCCCGGTACTC
HK1 laA-264_3p CAGAGCCACCTCTCTACCCAGGTAGGAGCCTCCCTTTTCAAAGATCAGAGCCAGGTACTC
HK1 laA-263_3p CAGAGCCACCTCTCTACCCAGGTAGGACCCCCCCTTTTCAAAGATCAGArGCCAGGTACTC

Contig8298594 CAGAGCCACCTCTCTACCCAGGTAGGAGCCTCCCTTTTCAAAGATCAGAGCCAGGTACTC
HK1 laA-276_3p TTCGTTATTTCTCGCAAAGAATCCATCAATCATCCTCCAACTTGGCAGGACTACAGTGAG
HK1 laA-264_3p TTCGTTATTTCTCGCAAAGAATCCATCAATC-TCCTCCAGCTTGGCAGG-CTCCAGTGGG
HK1 laA-263_3p TTCGTTATTTCTCGCAAAGAATCCAACAATC-TCCTCCAGCTTGGCAGG-CTCCAGTGGG

Contig8298594 TTCGTTATTTCTCGCAAAGAATCCATCAATC-TCCTCCAGCTTGGCAGG-CTCCAGTGGG
HK1 laA-276_3p GGACAGGCTGGGGGC
HK1 laA-264_3p GGACAGGCTGGGGGCCACGTGTCATGATGGG-ACTCCAGGGCGTCAATGAGCCTCTCCCG
HK1 laA-263_3p GGACAGGCTGGGGGCCACGTGTCATGAAGGGGACTCCAGGGCATCAAGGAACCTCGCCCG

Contig8298594 GGACAGGCTGGGGGCCACGTGTCATGAAGGGGACTCCAGGGCATCAAGGAACCTCGCCCG
HK1 laA-264_3p CAGCGTCTGCACGTCAGCACCAGCCACTGGAAATACTGCTCCCGAGCCGT-TCTTGGT-A

Page 38 sur 136 HKl laA-263_3p CGGACGCTGCACGTCAGCAGCAACGACTGGAAAAACTGCCACCGAGCCGGGTCTTGGTGA

Contig8298594 CAGACGCTGCACGTCAGCACCAACCACTGGAAAAACTGCCACCGAGCCGGGTCTTGGTGA
HK1 laA-264_3p AAGGCCTTGAAGAACCTCA-CAGTCGGGAAGCCAGGGATGTTG--AAGTCTCTGCACACT
HK1 1aA-263_3p AAGCCCCGGAAGAACCGCAGCGGGCGGAGAAGCGGGGACGGGGGCAAAACAACGCGGGAA

Contig8298594 AAGCCCCGGAAGAACCGCAGCAGGCGGAAAACCAGGGACGGGGGCAAAACAACGCACAAA
HK1 laA-264_3p GCGCTGTTGG
HK1 laA-263_3p GGGCCGGGAGGAGGGAAA

Contig8298594 GCGCCGGGAGGAGGGAAA

Contig8298594 Consensus sequence >Contig8298594 496 nt TCTCTGCAGGTAAGCGGTATAGAAGGACCTGGATTCCATGAGCACGGGGACTCGGGAGACAGAGCCATTCCGGAACAGC
A
GGTAGCAAGAGGGGAAGTCGGTGACACCAAACTTTCTCACCACATTGGCCTCTGTGTTCAGCACCCTGCGCACCGCCAC
G
CCTTTGTGCTGGGACAGGTCCAGAGCCACCTCTCTACCCAGGTAGGAGCCTCCCTTTTCAAAGATCAGAGCCAGGTACT
C
TTCGTTATTTCTCGCAAAGAATCCATCAATCTCCTCCAGCTTGGCAGGCTCCAGTGGGGGACAGGCTGGGGGCCACGTG
T
CATGAAGGGGACTCCAGGGCATCAAGGAACCTCGCCCGCAGACGCTGCACGTCAGCACCAACCACTGGAAAAACTGCCA
C
CGAGCCGGGTCTTGGTGAAAGCCCCGGAAGAACCGCAGCAGGCGGAAAACCAGGGACGGGGGCAAAACAACGCACAAAG
C
GCCGGGAGGAGGGAAA

back to table Contig8298598 Alignment HKl laA-51_3p ATTCTTCCTCCGCCTTCGCTTCGTTTCTGTCCCCTTTCGGTGTTAACTGGTCGCTATTTT

Contig8298598 ATTCTTCCTCCGCCTTCGCTTCGTTTCTGTCCCCTTTCGGTGTTAACTGGTCGCTATTTT
HK1 1aA-51_3p CTTATCTTCTCCTTCTCTTCCTCTTAAGTTTTCCTTGTCCCGCTTCGTGCCTACTTGTTG

Contig8298598 CTTATCTTCTCCTTCTCTTCCTCTTAAGTTTTCCTTGTCCCGCTTCGTGCCTACTTGTTG
HK1 laA-51_3p TAGATTTGCGCTTCTTTACACCGCTCCGTGGCCATCCCGTGTTATCTGTTTGGTGATTTG

Contig8298598 TAGATTTGCGCTTCTTTACACCGCTCCGTGGCCATCCCGTGTTATCTGTTTGGTGATTTG
HK1 laA-51_3p GATGGCTGCGCCTTTCCATCTTTAATGGTTCCGTCCCGGGGGAGTGCTCACTTTGGCTGG

Contig8298598 GATGGCTGCGCCTTTCCATCTTTAATGGTTCCGTCCCGGGGGAGTGCTCACTTTGGCTGG
HK1 laA-51_3p GTTTGTAAGGTTGACTCGGTGTTCCTAGCTATTGAGTGACGGCGCGCGTATGGAGGACAG

Contig8298598 GTTTGTAAGGTTGACTCGGTGTTCCTAGCTATTGAGTGACGGCGCGCGTATGGAGGACAG
HK1 laA-51_3p AGGCCTCCACGTCTGCAGGAACAGCGTGTCCTATGGCACAGAAGCGTGAAAGCCCCCACG

Page 39 sur 136 Contig8298598 AGGCCTCCACGTCTGCAGGAACAGCGTGTCCTATGGCACAGAAGCGTGAAAGCCCCCACG
HK1 laA-51_3p GTGCTGTGTTTGGCTTTGTTGCAGCGGAAAATGTGAGGGAG

Contig8298598 GTGCTGTGTTTGGCTTTGTTGCAGCGGAAAATGTGAGGGAG
Contig8298598 Consensus sequence >Contig8298598 401 nt ATTCTTCCTCCGCCTTCGCTTCGTTTCTGTCCCCTTTCGGTGTTAACTGGTCGCTATTTTCTTATCTTCTCCTTCTCTT
C
CTCTTAAGTTTTCCTTGTCCCGCTTCGTGCCTACTTGTTGTAGATTTGCGCTTCTTTACACCGCTCCGTGGCCATCCCG
T
GTTATCTGTTTGGTGATTTGGATGGCTGCGCCTTTCCATCTTTAATGGTTCCGTCCCGGGGGAGTGCTCACTTTGGCTG
G
GTTTGTAAGGTTGACTCGGTGTTCCTAGCTATTGAGTGACGGCGCGCGTATGGAGGACAGAGGCCTCCACGTCTGCAGG
A
ACAGCGTGTCCTATGGCACAGAAGCGTGAAAGCCCCCACGGTGCTGTGTTTGGCTTTGTTGCAGCGGAAAATGTGAGGG
A
G

back to table Contig8298600 Alignment HK1 laA-150_3p CGCAGATAACGACAGTGCAACGGGAATAGCAACTGAAACCAAATCCTCTTCTGCACCCAA

Contig8298600 CGCAGATAACGACAGTGCAACGGGAATAGCAACTGAAACCAAATCCTCTTCTGCACCCAA
HK1 laA-150_3p CGAAGGGTTGACCAAAGCGGCCATGATGGCAATGTCTGAGTATGAAGATCGGTTGTCATC

Contig8298600 CGAAGGGTTGACCAAAGCGGCCATGATGGCAATGTCTGAGTATGAAGATCGGTTGTCATC
HK1 laA-150_3p TGGTCTGGTCAGCCCGGCCCCGAGCTTTTATAGCAAGGAATATGACAATGAAGGTACAGT

Contig8298600 TGGTCTGGTCAGCCCGGCCCCGAGCTTTTATAGCAAGGAATATGACAATGAAGGTACAGT
HK1 laA-150_3p GGACTACAGTGAAACCTCAAGCCTTGCAGATCCCTGCTCCCCGAGTCCTGGTGCGAGTGG
HK1 laA-243_3p GTGAAACCTCAAGCCTTGCAGATCCCTGCTCCCCGAGTCCTGGTGCGAGTGG

Contig8298600 GGACTACAGTGAAACCTCAAGCCTTGCAGATCCCTGCTCCCCGAGTCCTGGTGCGAGTGG
HK1 laA-150_3p ATCTGCAGGCAAATCTGGTGACAGCGGGGATCGGCCTGGGCAGAAACGTTTTCGCACTCA
HK1 laA-243,_3p ATCTGCAGGCAAATCTGGTGACAGCGGGGATCGGCCTGGGCAGAAACGTTTTCGCACTCA

Contig8298600 ATCTGCAGGCAAATCTGGTGACAGCGGGGATCGGCCTGGGCAGAAACGTTTTCGCACTCA
HK1 laA-150_3p AATGACCAATCTGCAGCTGAAGGTCCTCAAGTCATGCTTTAATGACTACAGGACACCCAC
HK1 1aA-243_3p AATGACCAATCTGCAGCTGAAGGTCCTCAAGTCATGCTTTAATGACTACAGGACACCCAC

Contig8298600 AATGACCAATCTGCAGCTGAAGGTCCTCAAGTCATGCTTTAATGACTACAGGACACCCAC
HK1 laA-150_3p TATGCTAGAATGTGAGGTCCTGGGCAATGACATTGGACTGCCAAAGAGAGTCGTTCAGGT
HK1 1aA-243_3p TATGCTAGAATGTGAGGTCCTGGGCAATGACATTGGACTGCCAAAGAGAGTCGTTCAGGT

Page 40 sur 136 Contig8298600 TATGCTAGAATGTGAGGTCCTGGGCAATGACATTGGACTGCCAAAGAGAGTCGTTCAGGT
HK1 laA-150_3p CTGGTTCCAGAATGCCCGGGCAAAAGAAAAAAAGTC
HK1 laA-2433p CTGGTTCCAGAATGCCCGGGCAAAAGAAAAGAAGTCCAAGTTAAGCATGGCCAAGCATTT

Contig8298600 CTGGTTCCAGAATGCCCGGGCAAAAGAAAAAAAGTCCAAGTTAAGCATGGCCAAGCATTT
HK1 laA-243_3p TGGTATAAACCAAACGAGTTATGAGGGACCCAAAACAGAGTGCACTTTGTGTGGCATCAA

Contig8298600 TGGTATAAACCAAACGAGTTATGAGGGACCCAAAACAGAGTGCACTTTGTGTGGCATCAA
HK1 laA-243_3p GTACAGCGCTCGGCTGTCTGTACGTGACCATATCTTTTCCCAACAGCATATCTCCAAAGT

Contig8298600 GTACAGCGCTCGGCTGTCTGTACGTGACCATATCTTTTCCCAACAGCATATCTCCAAAGT
HK1 laA-243_3p TAAAGACACCATTGGAAGCCAGCTGGACAAGGAGAAAGAATACTT

Contig8298600 TAAAGACACCATTGGAAGCCAGCTGGACAAGGAGAAAGAATACTT
Contig8298600 Consensus sequence >Contig8298600 645 nt CGCAGATAACGACAGTGCAACGGGAATAGCAACTGAAACCAAATCCTCTTCTGCACCCAACGAAGGGTTGACCAAAGCG
G
CCATGATGGCAATGTCTGAGTATGAAGATCGGTTGTCATCTGGTCTGGTCAGCCCGGCCCCGAGCTTTTATAGCAAGGA
A
TATGACAATGAAGGTACAGTGGACTACAGTGAAACCTCAAGCCTTGCAGATCCCTGCTCCCCGAGTCCTGGTGCGAGTG
G
ATCTGCAGGCAAATCTGGTGACAGCGGGGATCGGCCTGGGCAGAAACGTTTTCGCACTCAAATGACCAATCTGCAGCTG
A
AGGTCCTCAAGTCATGCTTTAATGACTACAGGACACCCACTATGCTAGAATGTGAGGTCCTGGGCAATGACATTGGACT
G
CCAAAGAGAGTCGTTCAGGTCTGGTTCCAGAATGCCCGGGCAAAAGAAAAAAAGTCCAAGTTAAGCATGGCCAAGCATT
T
TGGTATAAACCAAACGAGTTATGAGGGACCCAAAACAGAGTGCACTTTGTGTGGCATCAAGTACAGCGCTCGGCTGTCT
G
TACGTGACCATATCTTTTCCCAACAGCATATCTCCAAAGTTAAAGACACCATTGGAAGCCAGCTGGACAAGGAGAAAGA
A
TACTT

back to table Contig8298604 Alignment HK1 laA-84_3p CCGCCTTTCTCCTCTATCCTCCCCGCCTCGCGCCCTGCGTCGCGTTCCCGCGCAGCGAGG

Contig8298604 CCGCCTTTCTCCTCTATCCTCCCCGCCTCGCGCCCTGCGTCGCGTTCCCGCGCAGCGAGG
HK1 laA-84_3p GTGTTCGCTTCAGTGCCCTTCGTCGGCGCTCGTGGTGCGCGTCCGCGCGCGTCCCCCTTC

Contig8298604 GTGTTCGCTTCAGTGCCCTTCGTCGGCGCTCGTGGTGCGCGTCCGCGCGCGTCCCCCTTC
HK1 laA-84_3p TCTCGCCTCCTTCCCTCTACCTCTCTTCTTGATTGGTCTACTGTCTGGAGTGCTATCTTC

Contig8298604 TCTCGCCTCCTTCCCTCTACCTCTCTTCTTGATTGGTCTACTGTCTGGAGTGCTATCTTC
HK1 laA-84_3p TCTCGCCACCTCGCACGAAACGTTCTGACCTTTGGCTCGCCGTGCGGTGCCCTCGGAGTC

Page 41 sur 136 Contig8298604 TCTCGCCACCTCGCACGAAACGTTCTGACCTTTGGCTCGCCGTGCGGTGCCCTCGGAGTC
HK1 laA-84_3p AATCTTTTGCAGAAAGATCATACGTTAACCCCAAAGATTGGCTTTCCTTGGAGTGAAATC

Contig8298604 AATCTTTTGCAGAAAGATCATACGTTAACCCCAAAGATTGGCTTTCCTTGGAGTGAAATC
HK1 laA-84_3p AGGAACATCTTTTTCAATGACAAAAAGTTTGTCATTAAACCCATCGACAAGAAGGCACCT

Contig8298604 AGGAACATCTTTTTCAATGACAAAAAGTTTGTCATTAAACCCATCGACAAGAAGGCACCT
HKl laA-84_3p GACTTTGTGTTTTATGCCCCACGTCTGAGAATCAACAAGCGGA

Contig8298604 GACTTTGTGTTTTATGCCCCACGTCTGAGAATCAACAAGCGGA
Contig8298604 Consensus sequence >Contig8298604 403 nt CCGCCTTTCTCCTCTATCCTCCCCGCCTCGCGCCCTGCGTCGCGTTCCCGCGCAGCGAGGGTGTTCGCTTCAGTGCCCT
T
CGTCGGCGCTCGTGGTGCGCGTCCGCGCGCGTCCCCCTTCTCTCGCCTCCTTCCCTCTACCTCTCTTCTTGATTGGTCT
A
CTGTCTGGAGTGCTATCTTCTCTCGCCACCTCGCACGAAACGTTCTGACCTTTGGCTCGCCGTGCGGTGCCCTCGGAGT
C
AATCTTTTGCAGAAAGATCATACGTTAACCCCAAAGATTGGCTTTCCTTGGAGTGAAATCAGGAACATCTTTTTCAATG
P.
CAAAAAGTTTGTCATTAAACCCATCGACAAGAAGGCACCTGACTTTGTGTTTTATGCCCCACGTCTGAGAATCAACAAG
C
GGA

back to table Contig8298606 Alignment HK1 laA-269_3p GCGATTCTGCCCTTGTAATCGGTGTCCCTGTAAAACAATCCCCACAGATTACTTTCAGAA
HK1 laA-269_5p GCGATTCTGCCCTTGTAATCGGTGTCCCTGTAAAACAATCCCCACAGATTACTTTCAAAA

Contig8298606 GCGATTCTGCCCTTGTAATCGGTGTCCCTGTAAAACAATCCCCACAGATTACTTTCAAAA
HK1 laA-269_3p ATAGATGTATTTCTCTACGTAAGGGCCAGGTTTATTTTCTCCTTTTTTGAGATTTCTAGA
HK1 1aA-269_5p ATAGATGTATTTCTCTACGTAAGGGCCAGGTTTATTTTCTCCTTTTTTGAGATTTCAAAA

Contig8298606 ATAGATGTATTTCTCTACGTAAGGGCCAGGTTTATTTTCTCCTTTTTTGAGATTTCAAAA
HK1 laA-269_3p AAAAATGCTGCTTGCACATGTTGGTTCTTGAAACCTTAGCTAGAAGAATTTCAGGTCATA
HK1 laA-269_5p AAAAATGCTGCTTGCACATGTTGGTTCTTGAAACCTTAGCTAGAAAAATTTCAGGTCATA

Contig8298606 AAAAATGCTGCTTGCACATGTTGGTTCTTGAAACCTTAGCTAGAAAAATTTCAGGTCATA
HK1 laA-269_3p CCAACATGTGGATAGGCTATAGCTGTTCAGAGGTCTCCTGGGGGAGCTTAAAACGGGGGA
HK1 laA-269_5p CCAACATGTGGATAGGCTATAGCTGTTCAGAGGTCTCCTGGGGGAGCTTAAAACGGGGGA

Contig8298606 CCAACATGTGGATAGGCTATAGCTGTTCAGAGGTCTCCTGGGGGAGCTTAAAACGGGGGA
HKl laA-269_3p AACACTGGTTTTCACAGATGCTCCACATGGCTGTCTTTAAAAGACTCAAAACTTTTTTTT

Page 42 sur 136 HK1 laA-269_5p AACACTGGTTTTCACAGATGCTCCACATGGCTGTCTTTAAAAGACTCAAAACTTTTTTTT

Contig8298606 AACACTGGTTTTCACAGATGCTCCACATGGCTGTCTTTAAAAGACTCAAAACTTTTTTTT
HK1 laA-269_3p GTCCTCTTTGTTATGCTTGGAAGCTCCCCCCCCC
HK1 laA-269_5p GTCCTCTTTGTTATGCTTGGAAGCTCCCCCCCCC

Contig8298606 GTCCTCTTTGTTATGCTTGGAAGCTCCCCCCCCC

Contig8298606 Consensus sequence >Contig8298606 334 nt GCGATTCTGCCCTTGTAATCGGTGTCCCTGTAAAACAATCCCCACAGATTACTTTCAAAAATAGATGTATTTCTCTACG
T
AAGGGCCAGGTTTATTTTCTCCTTTTTTGAGATTTCAAAAAAAAATGCTGCTTGCACATGTTGGTTCTTGAAACCTTAG
C
TAGAAAAATTTCAGGTCATACCAACATGTGGATAGGCTATAGCTGTTCAGAGGTCTCCTGGGGGAGCTTAAAACGGGGG
A
AACACTGGTTTTCACAGATGCTCCACATGGCTGTCTTTAAAAGACTCAAAACTTTTTTTTGTCCTCTTTGTTATGCTTG
G
AAGCTCCCCCCCCC

back to table Contig8298608 Alignment HK1 laA-148_3p ATCTTCCTTGCGCCGCGCTCCCTCCTCTCCCCTCCCTTCCCCCCCCCGGTCCCGCTCTCC

Contig8298608 ATCTTCCTTGCGCCGCGCTCCCTCCTCTCCCCTCCCTTCCCCCCCCCGGTCCCGCTCTCC
HK1 laA-148_3p CTCCCCCCCCCCCCCGNCTCCCCTTCGCTCTTCNCGGCCGGCGTCTCTCCTCCCCGTCCT

Contig8298608 CTCCCCCCCCCCCCCGNCTCCCCTTCGCTCTTCNCGGCCGGCGTCTCTCCTCCCCGTCCT
HK1 laA-148_3p CGTTNNNNNCCCCCCCCNCTTCNTCCCCCCCCCTCTCCCTCCCCCCCCCCCTCCNTTCCC

Contig8298608 CGTTNNNNNCCCCCCCCNCTTCNTCCCCCCCCCTCTCCCTCCCCCCCCCCCTCCNTTCCC
HK1 laA-148_3p GCGCCCCGCCCCCCGCTCCCCCCTCTCTCATTCCTCCCCCCCCCCGCCCCCGTTTTCTCT

Contig8298608 GCGCCCCGCCCCCCGCTCCCCCCTCTCTCATTCCTCCCCCCCCCCGCCCCCGTTTTCTCT
HK1 laA-148_3p CCCTTTCACTCTCCTTCCACCCGTCCGCTTTTTTTCTCCNNTCGTCCGGCCGCCCCGCTC

Contig8298608 CCCTTTCACTCTCCTTCCACCCGTCCGCTTTTTTTCTCCNNTCGTCCGGCCGCCCCGCTC
HKl laA-148_3p TTTCCTTGGGGGGGCTCCTATCTGCTCCCAAAATGCCCTCGGGCTCCTCGCGCTAAAACA

Contig8298608 TTTCCTTGGGGGGGCTCCTATCTGCTCCCAAAATGCCCTCGGGCTCCTCGCGCTAAAACA
HK1 laA-148_3p TTTCTAAAAAACATGGAGTGGCCTGTCCACCTGCGGCCACAGACTTGGAGTTGAGGGTCA

Contig8298608 TTTCTAAAAAACATGGAGTGGCCTGTCCACCTGCGGCCACAGACTTGGAGTTGAGGGTCA

Page 43 sur 136 HK1 laA-148_3p CCGCCGGACCAACAATACCCACCGTGGTGGGCTCCAGTACAGCTCCCCAGGACAGCTG

Contig8298608 CCGCCGGACCAACAATACCCACCGTGGTGGGCTCCAGTACAGCTCCCCAGGACAGCTG
Contig8298608 Consensus sequence >Contig8298608 478 nt ATCTTCCTTGCGCCGCGCTCCCTCCTCTCCCCTCCCTTCCCCCCCCCGGTCCCGCTCTCCCTCCCCCCCCCCCCCGNCT
C
CCCTTCGCTCTTCNCGGCCGGCGTCTCTCCTCCCCGTCCTCGTTNNNNNCCCCCCCCNCTTCNTCCCCCCCCCTCTCCC
T
CCCCCCCCCCCTCCNTTCCCGCGCCCCGCCCCCCGCTCCCCCCTCTCTCATTCCTCCCCCCCCCCGCCCCCGTTTTCTC
T
CCCTTTCACTCTCCTTCCACCCGTCCGCTTTTTTTCTCCNNTCGTCCGGCCGCCCCGCTCTTTCCTTGGGGGGGCTCCT
A
TCTGCTCCCAAAATGCCCTCGGGCTCCTCGCGCTAAAACATTTCTAAAAAACATGGAGTGGCCTGTCCACCTGCGGCCA
C
AGACTTGGAGTTGAGGGTCACCGCCGGACCAACAATACCCACCGTGGTGGGCTCCAGTACAGCTCCCCAGGACAGCTG
back to table Contig8298610 Alignment HK1 1aA-281_3p GTGATTTTAATAAGTAGGGGAAATGAGCAGAAATAAGATCTATATTTGGGGAGGAATTGC

Contig8298610 GTGATTTTAATAAGTAGGGGAAATGAGCAGAAATAAGATCTATATTTGGGGAGGAATTGC
HK1 1aA-281_3p ATAGCGTAGACCGGATGAAGAATCGGAAAGGAAGAACGTGGTTTTTCCCAAGGCCAATTT

Contig8298610 ATAGCGTAGACCGGATGAAGAATCGGAAAGGAAGAACGTGGTTTTTCCCAAGGCCAATTT
HK1 laA-281_3p CGCTCAAAATGGAACAGAACCAGGGAATTTTCAGGACAAAGTAAATGAACTGAAGTTTCC

Contig8298610 CGCTCAAAATGGAACAGAACCAGGGAATTTTCAGGACAAAGTAAATGAACTGAAGTTTCC
HK1 laA-281_3p ATCATGAGTTCATTCTATTAGCAGATGCCCAATTGACTTCCTCCTTGAGTCTTTATTAGG

Contig8298610 ATCATGAGTTCATTCTATTAGCAGATGCCCAATTGACTTCCTCCTTGAGTCTTTATTAGG
HK1 1aA-281_3p AGGCAGGCCTCAGACATTCACCCTACAGTCAGATACAACTTCAGTTCCTTACTTGGCTTC
HK1 laA-110_5p C

Contig8298610 AGGCAGGCCTCAGACATTCACCCTACAGTCAGATACAACTTCAGTTCCTTACTTGGCTTC
HK1 laA-281_3p TGTCAAGACGGTAAGAGTGCAAGGTGTCATATAATGACATTGCACAACTTTGTGGGAATC
HK1 1aA-110_5p TGTCAAGACGGTAAGAGTGCAAGGTGTCATA'TAATGACATTGCACAACTTTGTGGGAATC

Contig8298610 TGTCAAGACGGTAAGAGTGCAAGGTGTCATATAATGACATTGCACAACTTTGTGGGAATC
HK1 1aA-281._3p TATCTTTACTGAAGAATCATCGGACGGTATCAACTAACCATCTTTCCAAGCACAGGCTGG
HK1 laA-110_5p TATCTTTACTGAAGAATCATCGGACGGTATCAACTAACCATCTTTCCAAGCACAGGCTGG

Contig8298610 TATCTTTACTGAAGAATCATCGGACGGTATCAACTAACCATCTTTCCAAGCACAGGCTGG

Page 44 sur 136 HK1 laA-281_3p TTTGCAATTCTTGAACCTGGCGTTTCTTTTCTAAAGACTGAGTTCCGG
HK1 laA-110_5p TTTGCAATTCTTGAACCTGGCGTTTCTTTTCTAAAGACTGAGTTCCGGAAAGGGTTGGGG

Contig8298610 TTTGCAATTCTTGAACCTGGCGTTTCTTTTCTAAAGACTGAGTTCCGGAAAGGGTTGGGG
HK1 laA-110_5p CAACTCCCTGCAGGGCAGAGCTCCCGGCTTTGGTGCGTCCTTCCCAGCGCGCTCCATGGT

Contig8298610 CAACTCCCTGCAGGGCAGAGCTCCCGGCTTTGGTGCGTCCTTCCCAGCGCGCTCCATGGT
HK1 laA-110_5p CTGGGATGGGCGGTGGCGGCCCGGGCCGGCCTGCTACTTGAGGCAGGGACAGCAGAAGCA

Contig8298610 CTGGGATGGGCGGTGGCGGCCCGGGCCGGCCTGCTACTTGAGGCAGGGACAGCAGAAGCA
HK1 laA-110_5p GCAGAGGGTCCGGCAGGGGTTCTTCTCCTCGTACTGCACGGCCTTCCGCACCTGCGCCTT

Contig8298610 GCAGAGGGTCCGGCAGGGGTTCTTCTCCTCGTACTGCACGGCCTTCCGCACCTGCGCCTT
HK1 laA-110_5p GGCCTGGCCGGTGTAGTCGACCGTCTTTTGTACGTTGAGCTCG

Contig8298610 GGCCTGGCCGGTGTAGTCGACCGTCTTTTGTACGTTGAGCTCG
Contig8298610 Consensus sequence >Contig8298610 703 nt GTGATTTTAATAAGTAGGGGAAATGAGCAGAAATAAGATCTATATTTGGGGAGGAATTGCATAGCGTAGACCGGATGAA
G
AATCGGAAAGGAAGAACGTGGTTTTTCCCAAGGCCAATTTCGCTCAAAATGGAACAGAACCAGGGAATTTTCAGGACAA
A
GTAAATGAACTGAAGTTTCCATCATGAGTTCATTCTATTAGCAGATGCCCAATTGACTTCCTCCTTGAGTCTTTATTAG
G
AGGCAGGCCTCAGACATTCACCCTACAGTCAGATACAACTTCAGTTCCTTACTTGGCTTCTGTCAAGACGGTAAGAGTG
C
AAGGTGTCATATAATGACATTGCACAACTTTGTGGGAATCTATCTTTACTGAAGAATCATCGGACGGTATCAACTAACC
A
TCTTTCCAAGCACAGGCTGGTTTGCAATTCTTGAACCTGGCGTTTCTTTTCTAAAGACTGAGTTCCGGAAAGGGTTGGG
G
CAACTCCCTGCAGGGCAGAGCTCCCGGCTTTGGTGCGTCCTTCCCAGCGCGCTCCATGGTCTGGGATGGGCGGTGGCGG
C
CCGGGCCGGCCTGCTACTTGAGGCAGGGACAGCAGAAGCAGCAGAGGGTCCGGCAGGGGTTCTTCTCCTCGTACTGCAC
G
GCCTTCCGCACCTGCGCCTTGGCCTGGCCGGTGTAGTCGACCGTCTTTTGTACGTTGAGCTCG
back to table Contig8298613 Alignment -HK1 1aA-18_3p GGTCTTTTTGCTTTTCTTTTGTTGACGTCTTCTCTCCCCTCTCTCTCCTTACTTTTCTTT

Contig8298613 GGTCTTTTTGCTTTTCTTTTGTTGACGTCTTCTCTCCCCTCTCTCTCCTTACTTTTCTTT
HK1 1aA-18_3p TCCGATACTCTTCTTTCCTATGGTTTTACAGAAGCTCCTCATCTTAGCCTCTCTCCAGTT

Contig8298613 TCCGATACTCTTCTTTCCTATGGTTTTACAGAAGCTCCTCATCTTAGCCTCTCTCCAGTT
HK1 1aA-18_3p TCAGAGGCCTTTTAGTCCTTTCGTCTCTCTCTTTGCTCGTTTCCGAGCTGTCTAAAGTGA

Contig8298613 TCAGAGGCCTTTTAGTCCTTTCGTCTCTCTCTTTGCTCGTTTCCGAGCTGTCTAAAGTGA

Page 45 sur 136 HK1 laA-18_3p GTTTCTGAGTTTTGTGTGTGTAGCGCCTAGGGTCGTTATTTTTGGCACGAAGCTAGAGAC

Contig8298613 GTTTCTGAGTTTTGTGTGTGTAGCGCCTAGGGTCGTTATTTTTGGCACGAAGCTAGAGAC
HK1 laA-18_3p AAGTGAGGGCAGGCAGAGAAATGGTCAGGCCCGGGAGGAGNAGGATCAGAAGCAGAGGAG

Contig8298613 AAGTGAGGGCAGGCAGAGAAATGGTCAGGCCCGGGAGGAGNAGGATCAGAAGCAGAGGAG
HK1 laA-18_3p CGGGCAACAGCTGGAAACAGAGAAGAAAAGGAGAGAAACCGTGGAGAGAGAGAAAGAGCA

Contig8298613 CGGGCAACAGCTGGAAACAGAGAAGAAAAGGAGAGAAACCGTGGAGAGAGAGAAAGAGCA
HK1 laA-18_3p GAAGATGCGAGAGAAGGAGGAGATTGATGATGCGGCTGCAGGACTATGAGGA

Contig8298613 GAAGATGCGAGAGAAGGAGGAGATTGATGATGCGGCTGCAGGACTATGAGGA
Contig8298613 Consensus sequence >Contig8298613 412 nt GGTCTTTTTGCTTTTCTTTTGTTGACGTCTTCTCTCCCCTCTCTCTCCTTACTTTTCTTTTCCGATACTCTTCTTTCCT
A
TGGTTTTACAGAAGCTCCTCATCTTAGCCTCTCTCCAGTTTCAGAGGCCTTTTAGTCCTTTCGTCTCTCTCTTTGCTCG
T
TTCCGAGCTGTCTAAAGTGAGTTTCTGAGTTTTGTGTGTGTAGCGCCTAGGGTCGTTATTTTTGGCACGAAGCTAGAGA
C
AAGTGAGGGCAGGCAGAGAAATGGTCAGGCCCGGGAGGAGNAGGATCAGAAGCAGAGGAGCGGGCAACAGCTGGAAACA
G
AGAAGAAAAGGAGAGAAACCGTGGAGAGAGAGAAAGAGCAGAAGATGCGAGAGAAGGAGGAGATTGATGATGCGGCTGC
A
GGACTATGAGGA

back to table Contig8298615 Alignment HK1 laA-62_3p CATCTTATTTTCGTTATTTTTTGTGCTTGCCCTTTTTCTCTCTCCCGTCTCTTCCTCTTT

Contig8298615 CATCTTATTTTCGTTATTTTTTGTGCTTGCCCTTTTTCTCTCTCCCGTCTCTTCCTCTTT
HK1 laA-62_3p ATTTCTGATTTCTCTTATTTCCTAGTTTTGTTTTCTCTCCACTCTCTCTTTCTTCTTGCT

Contig829B615 ATTTCTGATTTCTCTTATTTCCTAGTTTTGTTTTCTCTCCACTCTCTCTTTCTTCTTGCT
HK1 laA-62_3p CCCTCCTTTTCCCTTCCTGGCTTCTTTCCTTCCGCTTTTTCTCCTCACTTCTCCTCCCTC

Contig8298615 CCCTCCTTTTCCCTTCCTGGCTTCTTTCCTTCCGCTTTTTCTCCTCACTTCTCCTCCCTC
HK1 laA-62_3p CGCCTCTCCTCACTCTATCTTTCCTTGGTACTTCTTCTCTCCTCGCGCGCCTCCTCTCCC

Contig8298615 CGCCTCTCCTCACTCTATCTTTCCTTGGTACTTCTTCTCTCCTCGCGCGCCTCCTCTCCC
HKl laA-62_3p TCTTTTTCCTCCTCCGCTTCGTCTCCCCTCTTCCTACTCGTTCGCTTCTTCCTCCTCTCT

Contig8298615 TCTTTTTCCTCCTCCGCTTCGTCTCCCCTCTTCCTACTCGTTCGCTTCTTCCTCCTCTCT

Page 46 sur 136 HK1 laA-62_3p TCTTTCTTCTTTCCTCTTTTCACCTTCCTCTCTTTCTTGCACCATTCCTCCCCCTACTCT

Contig8298615 TCTTTCTTCTTTCCTCTTTTCACCTTCCTCTCTTTCTTGCACCATTCCTCCCCCTACTCT
HK1 laA-62_3p CTTCCATTTTCTCAATCCCTTCTTTCACTCACTCTATTACCACCCTTTCTTTCTTTCTTT

Contig8298615 CTTCCATTTTCTCAATCCCTTCTTTCACTCACTCTATTACCACCCTTTCTTTCTTTCTTT
HK1 laA-62_3p TTACGCCCTCTTTTTTTGGATTTTTACCACCGC

Contig8298615 TTACGCCCTCTTTTTTTGGATTTTTACCACCGC

Contig8298615 Consensus sequence >Contig8298615 453 nt CATCTTATTTTCGTTATTTTTTGTGCTTGCCCTTTTTCTCTCTCCCGTCTCTTCCTCTTTATTTCTGATTTCTCTTATT
T
CCTAGTTTTGTTTTCTCTCCACTCTCTCTTTCTTCTTGCTCCCTCCTTTTCCCTTCCTGGCTTCTTTCCTTCCGCTTTT
T
CTCCTCACTTCTCCTCCCTCCGCCTCTCCTCACTCTATCTTTCCTTGGTACTTCTTCTCTCCTCGCGCGCCTCCTCTCC
C
TCTTTTTCCTCCTCCGCTTCGTCTCCCCTCTTCCTACTCGTTCGCTTCTTCCTCCTCTCTTCTTTCTTCTTTCCTCTTT
T
CACCTTCCTCTCTTTCTTGCACCATTCCTCCCCCTACTCTCTTCCATTTTCTCAATCCCTTCTTTCACTCACTCTATTA
C
CACCCTTTCTTTCTTTCTTTTTACGCCCTCTTTTTTTGGATTTTTACCACCGC

back to table Contig8298616 Alignment HK1 1aA-81_3p TTCTCTTTGCTTTTTCTTCGCTTCTGTCTCCTCTCTCCCTTCTTCCCCGCTCCGTTTCTC

Contig8298616 TTCTCTTTGCTTTTTCTTCGCTTCTGTCTCCTCTCTCCCTTCTTCCCCGCTCCGTTTCTC
HKl laA-81_3p CCTTTCCCTTTCCTCCTCCCCCTCTCCTCTCCGCCCCTCTTCCCGTTCTCTCCCCCGCCG

Contig8298616 CCTTTCCCTTTCCTCCTCCCCCTCTCCTCTCCGCCCCTCTTCCCGTTCTCTCCCCCGCCG
HK1 laA-81_3p TGCCCTCCTTCCCCCTCCTCCCTTTGCCCTCTCCCCTCCCGCCGCCGTCCGCCCGCTGCC

Contig8298616 TGCCCTCCTTCCCCCTCCTCCCTTTGCCCTCTCCCCTCCCGCCGCCGTCCGCCCGCTGCC
HK1 laA-81_3p CCCCGGGCCTCCCCCCCGTCCCCTCCCCGGTCCCCCCCCTCTCCTCCCCTCCCCCCGCGT

Contig8298616 CCCCGGGCCTCCCCCCCGTCCCCTCCCCGGTCCCCCCCCTCTCCTCCCCTCCCCCCGCGT
HK1 laA-81_3p CCCGCCCCGCCTCTGTCCCGCCCCCCGCCCCCGGCCGCCCCGCCCCCCCCCCNCCCCGCC

Contig8298616 CCCGCCCCGCCTCTGTCCCGCCCCCCGCCCCCGGCCGCCCCGCCCCCCCCCCNCCCCGCC
HK1 1aA-81_3p GCCCCCGGCCCCCCCCCCCCCCCCCCCCCCCCCTCCCCNCNCCCCCCCCAAGAAAAAAAA

Page 47 sur 136 Contig8298616 GCCCCCGGCCCCCCCCCCCCCCCCCCCCCCCCCTCCCCNCNCCCCCCCCAAGAAAAAAAA
HK1 laA-81_3p AAAAAAAA

Contig8298616 AAAAAAAA

Contig8298616 Consensus sequence >Contig8298616 368 nt TTCTCTTTGCTTTTTCTTCGCTTCTGTCTCCTCTCTCCCTTCTTCCCCGCTCCGTTTCTCCCTTTCCCTTTCCTCCTCC
C
CCTCTCCTCTCCGCCCCTCTTCCCGTTCTCTCCCCCGCCGTGCCCTCCTTCCCCCTCCTCCCTTTGCCCTCTCCCCTCC
C
GCCGCCGTCCGCCCGCTGCCCCCCGGGCCTCCCCCCCGTCCCCTCCCCGGTCCCCCCCCTCTCCTCCCCTCCCCCCGCG
T
CCCGCCCCGCCTCTGTCCCGCCCCCCGCCCCCGGCCGCCCCGCCCCCCCCCCNCCCCGCCGCCCCCGGCCCCCCCCCCC
C
CCCCCCCCCCCCCTCCCCNCNCCCCCCCCAAGAAAAAAAAAAAAAAAA
back to table Contig8298618 Alignment HK1 laA-170_3p GTCCCCCCCTCTTGTATTTGCCCCTTCCCGCCCCTTCTCTCCCGTTCTCTCCCCTCCCCT

Contig8298618 GTCCCCCCCTCTTGTATTTGCCCCTTCCCGCCCCTTCTCTCCCGTTCTCTCCCCTCCCCT
HK1 laA-170_3p GCTCTCCCCCCCCTCTCCCTCCCCTCCGCCCTTGCTCTTCGCCCCTCCATACATCCTTTC

Contig8298618 GCTCTCCCCCCCCTCTCCCTCCCCTCCGCCCTTGCTCTTCGCCCCTCCATACATCCTTTC
HK1 1aA-170_3p TCCCTCCCCCCGTCGCTCTCCTCTTTATTCTTTCTTTCTTCTTACTCCCGCGTGCGAGGG

Contig8298618 TCCCTCCCCCCGTCGCTCTCCTCTTTATTCTTTCTTTCTTCTTACTCCCGCGTGCGAGGG
HK1 laA-170_3p TTCCCTCCCTTCGCCTCCTCTCTCCCCCGCCCACTACCGCTTCCCTATTCCTCCCCCCCG

Contig8298618 TTCCCTCCCTTCGCCTCCTCTCTCCCCCGCCCACTACCGCTTCCCTATTCCTCCCCCCCG
HK1 1aA-170_3p CGGGAACTCTCCCTCACAAATTTTTTTTTTTTTTTCTCCTGCCCCCCCCCGCCCGTTCCC

Contig8298618 CGGGAACTCTCCCTCACAAATTTTTTTTTTTTTTTCTCCTGCCCCCCCCCGCCCGTTCCC =
HK1 laA-170_3p GCGCCTCCGGGAAGCTTTTCTCCCCTGGGGGGGCCCTACTGCAACAAAACCTCCAAACCT

Contig8298618 GCGCCTCCGGGAAGCTTTTCTCCCCTGGGGGGGCCCTACTGCAACAAAACCTCCAAACCT
HK1 laA-170_3p TTTTAAACCTTTTTGGAACCAATCCCAAAAACACGGGGAAACCCCCGGGGGAAGGAAAAA

Contig8298618 TTTTAAACCTTTTTGGAACCAATCCCAAAAACACGGGGAAACCCCCGGGGGAAGGAAAAA
HK1 laA-170_3p ACCCGCCCTTTAATTTACCCCCTGGGTTCCCAAAAAAAAAGTTCCCCCGGGGGTAAAAAA

Page 48 sur 136 Contig8298618 ACCCGCCCTTTAATTTACCCCCTGGGTTCCCAAAAAAAAAGTTCCCCCGGGGGTAAAAAA
HK1 laA-170_3p AAAAAAAAAAAAAAA

Contig8298618 AAAAAAAAAAAAAAA

Contig8298618 Consensus sequence >Contig8298618 495 nt GTCCCCCCCTCTTGTATTTGCCCCTTCCCGCCCCTTCTCTCCCGTTCTCTCCCCTCCCCTGCTCTCCCCCCCCTCTCCC
T
CCCCTCCGCCCTTGCTCTTCGCCCCTCCATACATCCTTTCTCCCTCCCCCCGTCGCTCTCCTCTTTATTCTTTCTTTCT
T
CTTACTCCCGCGTGCGAGGGTTCCCTCCCTTCGCCTCCTCTCTCCCCCGCCCACTACCGCTTCCCTATTCCTCCCCCCC
G
CGGGAACTCTCCCTCACAAATTTTTTTTTTTTTTTCTCCTGCCCCCCCCCGCCCGTTCCCGCGCCTCCGGGAAGCTTTT
C
TCCCCTGGGGGGGCCCTACTGCAACAAAACCTCCAAACCTTTTTAAACCTTTTTGGAACCAATCCCAAAAACACGGGGA
A
ACCCCCGGGGGAAGGAAAAAACCCGCCCTTTAATTTACCCCCTGGGTTCCCAAAAAAAAA.GTTCCCCCGGGGGTAAAA
AA
AAAAAAAAAAAAAAA

back to table Contig8298620 Alignment HK1 laA-234_5p CGACCCCCGCTGCGGCGGTTGCTGTTGCGGCTGCTGCCGCCGCCACCTTGGGTCGGGGTC

Contig8298620 CGACCCCCGCTGCGGCGGTTGCTGTTGCGGCTGCTGCCGCCGCCACCTTGGGTCGGGGTC
HK1 laA-234_5p TTAAATTTAGACGCGGAGGCCCCAGCTTTACTCTCGGGCCCCCCGGTTTTTTTTTTAAGA

Contig8298620 TTAAATTTAGACGCGGAGGCCCCAGCTTTACTCTCGGGCCCCCCGGTTTTTTTTTTAAGA
HK1 laA-234_5p TTCTAAGTGGATTTTCACCGGCCGGGAACAGACGGGGTCATTGTGCTGGTGGAACCACCC

Contig8298620 TTCTAAGTGGATTTTCACCGGCCGGGAACAGACGGGGTCATTGTGCTGGTGGAACCACCC
HK1 laA-234_5p AAGACTAATACCACCCAGCCGGGAGTGCTGCAGGGGGGTGCTGTCTACCTCTGTCCTTGG

Contig8298620 AAGACTAATACCACCCAGCCGGGAGTGCTGCAGGGGGGTGCTGTCTACCTCTGTCCTTGG
HK1 laA-234_5p GGTGCCGCCCGCCCACATTGCACGAAAATTAAATTTAACAGCGAGGGGGCGCGGGCTCGA

Contig8298620 GGTGCCGCCCGCCCACATTGCACGAAAATTAAATTTAACAGCGAGGGGGCGCGGGCTCGA
HK1 laA-234_5p GGAGGAATAAAGAAAAAAAGAAAAAGGAGAAAGAACCATTTATATTAAGACTCCGGGGGA

Contig8298620 GGAGGAATAAAGAAAAAAAGAAAAAGGAGAAAGAACCATTTATATTAAGACTCCGGGGGA
HK1 laA-234_5p GAGGTGAGGGGACAAAACCTCGCGAGGCGAGGCGGGGAGGAGAGGGGAGAGAGCCCGGAA

Contig8298620 GAGGTGAGGGGACAAAACCTCGCGAGGCGAGGCGGGGAGGAGAGGGGAGAGAGCCCGGAA
HK1 laA-234_5p TAGAGAAAATAGAAGAAAAGAAAAAGACCAGCCGAAGCCTGACAAAACAACAAGGGAGAA

Page 49 sur 136 Contig8298620 TAGAGAAAATAGAAGAAAAGAAAAAGACCAGCCGAAGCCTGACAAAACAACAAGGGAGAA
HK1 laA-234_5p AATTCAAGAAAGAGGAAAGAGGGAATATAGGAAAAGAAGAAGGCGAAGTAAAGAAGAG

Contig8298620 AATTCAAGAAAGAGGAAAGAGGGAATATAGGAAAAGAAGAAGGCGAAGTAAAGAAGAG
Contig8298620 Consensus sequence >Contig8298620 538 nt CGACCCCCGCTGCGGCGGTTGCTGTTGCGGCTGCTGCCGCCGCCACCTTGGGTCGGGGTCTTAAATTTAGACGCGGAGG
C
CCCAGCTTTACTCTCGGGCCCCCCGGTTTTTTTTTTAAGATTCTAAGTGGATTTTCACCGGCCGGGAACAGACGGGGTC
A
TTGTGCTGGTGGAACCACCCAAGACTAATACCACCCAGCCGGGAGTGCTGCAGGGGGGTGCTGTCTACCTCTGTCCTTG
G
GGTGCCGCCCGCCCACATTGCACGAAAATTAAATTTAACAGCGAGGGGGCGCGGGCTCGAGGAGGAATAAAGAAAAAAA
G
AAAAAGGAGAAAGAACCATTTATATTAAGACTCCGGGGGAGAGGTGAGGGGACAAAACCTCGCGAGGCGAGGCGGGGAG
G
AGAGGGGAGAGAGCCCGGAATAGAGAAAATAGAAGAAAAGAAAAAGACCAGCCGAAGCCTGACAAAACAACAAGGGAGA
A
AATTCAAGAAAGAGGAAAGAGGGAATATAGGAAAAGAAGAAGGCGAAGTAAAGAAGAG
back to table Contig8298622 Alignment HK1 1aA-48_5p CGACCCCCGCTGCTGCCGCTGCTGTTGCTGCTGCTGCCGCCGCCACCCAGGGTCGGGGGC
HK1 laA-266_5p CGACCCCCGCTGCTGCCGCTGCTGTTGCTGCTGCTGCCGCCGCCACCTAGGGTCGGGGGC
HK1 1aA-168_5p CGACCCCCGCTGCTGCCGCTGCTGTTGCTGCTGCTGCCGCCGCCACCCAGGGTCGGGGGC
HK1 laA-1_5p CGGCTGCTGCCGCTGCTGTTGCTGCTGCTGCCGCCGCCACCCAGGGTCGGGGGC
HK1 laA-255_5p CGGCTGCTGCCGCTGCTGTTGCTGCTGCTGCCGCCCCCACCCAGGGTCGGGGGC
HK1 laA-24_5p CGGCTGCTGCCGCTGCTGTTGCTGCTGCTGCCGCCGCCACCCAGGGTCGGGGGC
HK1 1aA-7_5p CCGCTGCTGCCGCTGCTGTTGCTGCTGCTGCCGCCGCCACCCAGGGTCGGGGGC
HK1 1aA-279_5p CGGCTGCTGCCGCTGCTGTTGCTGCTGCTGCCGCCGCCACCCAGGGTCGGGGGC
HKl laA-131_5p CCGCTGCTGCCGCTGCTGTTGCTGCTGCTGCCGCCGCCACCCAGGGTCGGGGGC
HK1 laA-200_5p CCGCTGCTGCCGCTGCTGTTGCTGCTGCTGCCGCCGCCACCCAGGGTCGGGGGC

Contig8298622 CGACCCCCGCTGCTGCCGCTGCTGTTGCTGCTGCTGCCGCCGCCACCCAGGGTCGGGGGC
HK1 laA-48_5p TTCAACTTAAACGCGGAGGCCCCAGCAGTACTCTCGGGGCCCCCGGGCTCCTTCTTCGGA
HK1 laA-266_5p TTCAACTTAAACCCGGAGGCCCCAGCATTACTCTCGGGGCCCCCGGTTTTTTTTTTTGGA
HK1 1aA-168_5p TTCAACTTAGACGCGGAGGCCCCAGCAGTACTCTCGGGGCCCCCGGGCTCCTTCTTCGGA
HK1 laA-1_5p TTCAACTTAAACGCGGAGGCCCCAGCAGTACTCTCGGGGCCCCCGGGCTCCTTCTTCGGA
HK1 laA-255_5p TTCAACTTAAACGCGGAGGCCCCAGCAGTACTCTCGGGGCCCCCGGGCTCCTTTTTCGGA
HK1 laA-24_5p TTCAACTTAGACGCGGAGGCCCCAGCAGTACTCTCGGGGCCCCCGGGCTTTTTTTTCTGA
HK1 laA-7_5p TTCAACTTAAACGCGGAGGCCCCAGCAGTACTCTCGGGGCCCCCGGGCTCCTTCTTCGGA
HK1 laA-279_5p TTCAACTTAAACGCGGAGGCCCCAGCAGTACTCTCGGGGCCCCCGGGCTCCTTCTTCGGA
HK1 1aA-131_5p TTCAACTTAGACGCGGAGGCCCCAGCAGTACTCTCGGGGCCCCCGGGCTCCTTCTTCGGA
HK1 laA-200_5p TTCAACTTAGACGCGGAGGCCCCAGCAGTACTCTCGGGGCCCCCGGGCTCCTTCTTCGGA

Contig8298622 TTCAACTTAAACGCGGAGGCCCCAGCAGTACTCTCGGGGCCCCCGGGCTCCTTCTTCGGA
HK1 laA-48_5p TTCTCAGTGGAGTTTTACCGGCCGGGAACAGACGGGGTCAGTGTGCTGGTGGGACCACCC
HK1 laA-266_5p TTCTCAGTGGAGTTTTACCGGCCGGGAACAGACGGGGTCATTGTGCTGGTGGGACCACCC
HK1 laA-168_5p TTCTCAGTGGAGTTTTACCGGCCGGGAACAGACGGGGTCAGTGTGCTGGTGGGAGCACCC
HK1 laA-1_5p TTCTCAGTGGAGTTTTACCGGCCGGGAACAGACGGGGTCAGTGTGCTGGTGGGAGCACCC
HK1 laA-255_5p TTCTCAGTGGAGTTTTACCGGCCGGGAACAGACGGGGTCATTGTGCTGGTGGGACCACCC
HK1 laA-24_5p TTCTCAGTGGAGTTTTACCGGCCGGGAACAGACGGGGTCAGTGTGCTGGTGGGAGCACCC

Page 50 sur 136 HK1 1aA-7l5p TTCTCAGTGGAGTTTTACCGGCCGGGAACAGACGGGGTCAGTGTGCTGGTGGGAGCACCC
HK1 laA-2795p TTCTCAGTGGAGTTTTACCGGCCGGGAACAGACGGGGTCAGTGTGCTGGTGGGACCACCC
HK1 laA-1315p TTCTCAGTGGAGTTTTACCGGCCGGGAACAGACGGGGTCAGTGTGCTGGTGGGAGCACCC
HK1 laA-200_5p TTCTCAGTGGAGTTTTACCGGCCGGGAACAGACGGGGTCAGTGTGCTGGTGGGACCACCC

Contig8298622 TTCTCAGTGGAGTTTTACCGGCCGGGAACAGACGGGGTCAGTGTGCTGGTGGGACCACCC
HK1 laA-48_5p AAGGCTAATACCACCCAGCCAGGAGTGCTGCAGGGTGGTGCTGTCTACCTCTGTCCTTGG
HK1 laA-266_5p AAGGCTAATACCACCCACCCAGGAGTGCTGCAGGGTGGTGCTGTCTACCTCTGTCCTTGG
HK1 laA-168_5p AAGGCTAATACCAGCCAGCCAGGAGTGCTGCAGGGTGGTGCTGTCTACCTCTGTCCTTGG
HK1 laA-1_5p AAGGCTAATACCACCCAGCCAGGAGTGCTGCAGGGTGGTGCTGTCTACCTCTGTCCTTGG
HK1 laA-255_5p AAGGCTAATACCACCCACCCAGGAGTGCTGCAGGGTGGTGCTGTCTACCTCTGTCCTTGG
HK1 laA-24_5p AAGGCTAATACCACCCAGCCAGGAGTGCTGCAGGGTGGTGCTGTCTACCTCTGTCCTTGG
HK1 laA-7_5p AAGGCTAATACCAGCCAGCCAGGAGTGCTGCAGGGTGGTGCTGTCTACCTCTGTCCTTGG
HK1 laA-279_5p AAGGCTAATACCACCCACCCAGGAGTGCTGCAGGGTGGTGCTGTCTACCTCTGTCCTTGG
HK1 laA-131_5p AAGGCTAATACCAGCCAGCCAGGAGTGCTGCAGGGTGGTGCTGTCTACCTCTGTCCTTGG
HK1 laA-200._5p AAGGCTAATACCACCCAGCCAGGAGTGCTGCAGGGTGGTGCTGTCTACCTCTGTCCTTGG

Contig8298622 AAGGCTAATACCACCCAGCCAGGAGTGCTGCAGGGTGGTGCTGTCTACCTCTGTCCTTGG
HK1 laA-48_5p GGTGCCACCCCCACACAGTGCACCCCCATTGAATTTGACAGCAAAGGCTCTCGGCTCCTG
HK1 laA-266_5p GGTGCCACCCCCACACAGTGCACCCCAATTGAATTTGACGGCAAAGGCTCTCGGCTCCTG
HK1 laA-168_5p GGTGCCAGCCCCACACAGTGCACCCCCATTGAATTTGACAGCAAAGGCTCTCGGCTCCTG
HK1 laA-1_5p GGTGCCAGCCCCACACAGTGCACCCCCATTGAATTTGACAGCAAAGGCTCTCGGCTCCTG
HK1 1aA-255_5p GGTGCCACCCCCACACAGTGCACCCCCATTGAATTTGACAGCNAAGGCTCTCGGCTCCTG
HK1 laA-24_5p GGTGCCACCCCCACACAGTGCACCCCCATTGAATTTGACAGCAAAGGCTCTCGGCTCCTG
HK1 laA-7__5p GGTGCCAGCCCCACACAGTGCACCCCCATTGAATTTGACAGCAAAGGCTCTCGGCTCCTG
HK1 laA-279_5p GGTGCCACCCCCACACAGTGCACCCCCATTGAATTTGACAGCNAAGGCTCTCGGCTCCTG
HK1 laA-131_5p GGTGCCAGCCCCACACAGTGCACCCCCATTGAATTTGACAGCAAAGGCTCTCGGCTCCTG
HK1 laA-200_5p GGTGCCAGCCCCACACAGTGCACCCCCATTGAATTTGACAGCAAAGGCTCTCGGCTCCTG

Contig8298622 GGTGCCACCCCCACACAGTGCACCCCCATTGAATTTGACAGCAAAGGCTCTCGGCTCCTG
HK1 laA-48_5p GAGTCCTCACTGTCCAGCTCAAAGGGAGAGGAGCCTGTGGAGTACAAGTCC-TTGCAGTG
HK1 laA-266_5p AANTCCTCAATGTCCAGCTAAGAGGGAGAGGACCCTGTGGAGTACAATTCC-TTGGAGTG
HK1 laA-168_5p GAGTCCTCACTGTCCAGCTCAGAGGGAGAGGAGCCTGTGGAGTACAAGTCC-TTGCAGTG
HK1 laA-1_5p GAGTCCTCACTGTCCAGCTCAAAGGGAGAGGAGCCTGTGGAGTACAAGTCC-TTGCAGTG
HK1 laA-255_5p GAGTCCTCACTGTCCAAATAAAAGGGAGAGGACCCTGTGGAGTACATTTCC-TTGCAGTG
HK1 laA-24_5p GAGTCCTCACTGTCCAGCTCAGAGGGAGAGGAGCCTGTGGAGTACAAGTCC-TTGCAGTG
HK1 laA-7_5p GAGTCCTCACTGTCCAGCTCAAAGGGAGAGGAGCCTGTGGAGTACAAGTCCCTTGCAGTG
HK1 laA-279_5p GAGTCCTCACTGGCCAGCTAAAAGGGAGAGGACCCTGTGGAGTACAATTCC-TTGCAGTG
HK1 laA-131_5p GAGTCCTCACTGTCCAGCTCAGAGGGAGAGGAGCCTGTGGAGTACAAGTCC-TTGCAGTG
HK1 laA-200_5p GAGTCCTCACTGTCCAGCTAAGAGGGAGAGGAGCCTGTGGAGTACAAGTCC-TTGCAGTG

Contig8298622 GAGTCCTCACTGTCCAGCTCAAAGGGAGAGGAGCCTGTGGAGTACAAGTCC-TTGCAGTG
HK1 laA-48-_5p GTTCGGGGCAACAGTTCGAGCCCATGGCTCCTCCATCTTGGCATGCGCTC
HK1 1aA-266_5p GTTCGGGACAACAGTTCCAGCCCATGGCTCCTCCATCTTGGGATGCGC
HK1 laA-168_5p GTTCGGGGCAACAGTTCGAGCCCATGGCTCCTCCATCTTGGCATGCG
HK1 laA-1_5p GTTCGGGGCAACAGTTCGAGCCCATGGCTCCTCCATCTTGGCATGCGCTCCA
HK1 laA-255_Sp GTTCGGAGCAACAGTTCGAGCCCATGGCTCCTCCATCTAGGCAGGCGCTCCA
HK1 1aA-24_5p GTTCGGGGCAACAGTTCGAGCCCATGGCTCCTCCATCTTGGCATGCCCTCCACTGTACA
HK1 laA-7_5p GTTCGGGGCAACAGTTCGAGCCCATGGCTCCTCCATCTTGGCATGCGCTCCACTGTACAG
HK1 1aA-279_5p GTTCGGGGCAACAGTTCGAGCCCATGGCTCCTCCATCTTGGCATGCGCTCCACTGTACA
HK1 1aA-131_5p GTTCGGGGCAACAGTTCGAGCCCATGGCTCCTCCATCTTGGCATGCGCTC
HK1 laA-200_5p GTTCGGGGCAACAGTTCGAGCCCATGGCTCCTCCATCTTGGCATGCGCTCCACTGTACAG

Contig8298622 GTTCGGGGCAACAGTTCGAGCCCATGGCTCCTCCATCTTGGCATGCGCTCCACTGTACAG

Page 51 sur 136 HK1 laA-7_5p CTGGCGC
HK1 laA-200_5p CTGGCGCACAGAAAAGGAGCCACTGAGCGACCCCGTGGGCACCTGCTACCTCTACACAGA
HK1 laA-153__.3p GA
HK1 laA-140_3p GA

Contig8298622 CTGGCGCACAGAAAAGGAGCCACTGAGCGACCCCGTGGGCACCTGCTACCTCTACACAGA
HK1 laA-200_5p TAACTTCACCCGAATTCTGGAGTATGCACCCTGCCG
HK1 laA-1533p TAACTTCACCCGAATTCTGGAGTATGCACCCTGCCGCTCAGATTTCAGCTGGGCAGCAGG
HK1 laA-140_3p TAACTTCACCAGAATTCTGGAGTATGCACCCTGCCGCTCAGATTTCAGCTTGGCAGCAGG
HK1 laA-2553p TCTGGAGTATGCACCCTGCCGCTCAGATTTCAGCTGGGCAGCAGG
HK1 laA-2793p AGTATGCACCCTGCCGCTCAGATTTCAGCTGGGCAGCAGG
HK1 laA-243p TATGCACCCTGCCGCTCAGATTTCAGCTGGGCAGCAGG

Contig8298622 TAACTTCACCCGAATTCTGGAGTATGCACCCTGCCGCTCAGATTTCAGCTGGGCAGCAGG
HK1 laA-153_3p ACAGGGTTACTGCCAAGGAGGCTTCAGTGCCGAGTTCACCAAGACTGGCCGTGTGGTTTT
HKI laA-140_3p ACAGGGTTACTGCCAAGGAGGCTTCAGTGCCGAGTTCACCAAGACTGGCCGCGTGGTTTT
HK1 laA-255_3p ACAGGGTTACTGCCAAGGAGGCTTCAGTGCCGAGTTCACCAAGACTGGCCGTGTGGTTTT
HKI laA-279_3p ACAGGGTTACTGCCAAGGAGGCTTCAGTGCCGAGTTCACCAAGACTGGCCGTGTGGTTTT
HK1 laA-24_3p ACAGGGTTACTGCCAAGGAGGCTTCAGTGCCGAGTTCACCAAGACTGGCCGTGTGGTTTT

Contig8298622 ACAGGGTTACTGCCAAGGAGGCTTCAGTGCCGAGTTCACCAAGACTGGCCGTGTGGTTTT
HK1 laA-153_3p AGGTGGACCAGGAAGCTATTTCTGGCAAGGCCAGATCCTGTCTGCCACTCAGGAGCAGAT
HK1 1aA-140_3p AGGTGGACCAGGAAGCTATTTCTGGCAAGGCCAGATCCTGTCTGCCACTCAGGAGCAGAT
HKI laA-1_3p TCTGGCAAGGCCAGATCCTGTCTGCCATTCAGGAGCAGAT
HK1 1aA-255_3p AGGTGGACCAGGAAGCTATTTCTGGCAAGGCCAGATCCTGTCTGCCACTCAGGAGCAGAT
HK1 laA-273-3p AGGTGGACCAGGAAGCTATTTCTGGCAAGGCCAGATCCTGTCTGCCACTCAGGAGCAGAT
HK1 laA-24_3p AGGTGGACCAGGAAGCTATTTCTGGCAAGGCCAGATCCTGTCTGCCACTCAGGAGCAGAT
HK1 laA-200_3p CCAGGAAGCTATTTCTGGCAAGGCCAGATCCTGTCTGCCACTCAGGAGCAGAT
HK1 laA-234_3p CAGGAAGCTATTTCTGGCAAGGCCAGATCCTGTCTGCCACTCAGGAGCAGAT
HK1 laA-131_3p GAGCAGAT
HK1 laA-266_3p AGGCCAGATCCTGTCTGCCACTCAGGAGCAGAT

Contig8298622 AGGTGGACCAGGAAGCTATTTCTGGCAAGGCCAGATCCTGTCTGCCACTCAGGAGCAGAT
HK1 laA-153_3p TGCAGAATCTTATTACCCCGAGTACCTGATCAACCTGGTTCAGGGGCAGCTGCAGACTCG
HK1 laA-140_3p TGCAGAATCTTATTACCCCGAGTACCTGATCAACCTGGTTCAGGGGCAGNTGCAGACTCG
HK1 laA-1_3p TGCAGAATCTTATTACCCCGAGTACTTGATCAACCTGGTTCAGGGGCAGCTGCAGACTCG
HK1 SaA-255_3p TGCAGAATCTTATTACCCCGAGTACCTGATCAACCTGGTTCAGGGGCAGCTGCAGACTCG
HK1 laA-279_3p TGCAGAATCTTATTACCCCGAGTACCTGATCAACCTGGTTCAGGGGCAGCTGCAGACTCG
HK1 laA-24_3p TGCAGAATCTTATTACCCCGAGTACCTGATCAACCTGGTTCAGGGGCAGCTGCAGACTCG
HKI laA-200_3p TGCAGAATCTTATTACCCCGAGTACCTGATCAACCTGGTTCAGGGGCAGCTGCAGACTCG
HK1 laA-234_3p TGCAGAATCTTATTACCCCGAGTACNTGATCAACCTGGTTCAGGGGCAGCTGCAGACTCG
HK1 laA-7_3p GGTTCAGGGGCAGCTGCAGACTCG
HK1 laA-131_3p CGCAGAATCTTATCACCCCGAGTACCTGATCAACTTGGTTCAGGGGCAGCTGCAGACTCG
HK1 laA-266_3p TGCAGAATCTTATTACCCCGAGTACCTGATCAACCTGGTTCAGGGGCAGCTGCAGACTCG

Contig8298622 TGCAGAATCTTATTACCCCGAGTACCTGATCAACCTGGTTCAGGGGCAGCTGCAGACTCG
HK1 laA-153_3p CCAGGCCAGTTCCATCTATGATGACAGCTACCTAGGATACTCTGTGGCTGTTGGTGAATT
HK1 laA-140_3p CCAGGCCAGTTCCATCTATGATGACAGCTACCTAGGATACTCTGTGGCTGTTGGTGAATT
HK1 laA-1_3p TCAGGCCAGTTCCATCTATGATGACAGCTACCTAGGATACTCTGTGGCTGTTGGTGAATT
HK1 laA-255_3p CCAGGCCAGTTCCATCTATGATGACAGCTACCTAGGATACTCTGTGGCTGTTGGTGAATT
HK1 laA-279_3p CCAGGCCAGTTCCATCTATGATGACAGCTACCTAGGATACTCTGTGGCTGTTGGTGAATT
HK1 laA-24_3p CCAGGCCAGTTCCATCTATGATGACAGCTACCTAGGATACTCTGTGGCTGTTGGTGAATT
HKI laA-200_3p CCAGGCCAGTTCCATCTATGATGACAGCTACCTAGGATACTCTGTGGCTGTTGGTGAATT
HK1 laA-234_3p CCAGGCCAGTTCCATCTATGATGACAGCTACCTAGGATACTCTGTGGCTGTTGGTGAATT

Page 52 sur 136 HK1 laA-7_3p CCAGGCCAGTTCCATCTATGATGACAGCTACCTAGGATACTCTGTGGCTGTTGGTGAATT
HK1 laA-131_3p CCAGGCCAGTTCCATCTATGATGACAGCTACCTAGGATACTCTGTGGCTGTTGGTGAATT
HK1 laA-266_3p CCAGGCCAGTTCCATCTATGATGACAGCTACCTAGGATACTCTGTGGCTGTTGGTGAATT

Conti98298622 CCAGGCCAGTTCCATCTATGATGACAGCTACCTAGGATACTCTGTGGCTGTTGGTGAATT
HK1 laA-153_3p CAGTGGTGATGACACAGAAGACTTTGTTGCTGGTGTGCCCAAAGGGAACCTCACTTACGG
HK1 laA-140_3p CAGTGGTGATGACACAGAAGACTTTGTTGCTGGTGTGCCCAAAGGGAACCTCACTTACGG
HK1 laA-1_3p CAGTGGTGATGACACAGAAGACTTTGTTGNTGGTGTGCCCAAAGGGAACCTCACTTACGG
HK1 laA-255_3p CAGTGGTGATGACACAGAAGACTTTGTTGCTGGTGTGCCCAAAGGGAACCTCACTTACGG
HK1 laA-279_3p CAGTGGTGATGACACAGAAGACTTTGTTGCTGGTGTGCCCAAAGGGAACCTCACTTACGG
HK1 laA-24_3p CAGTGGTGATGACACAGAAGACTTTGTTGCTGGTGTGCCCAAAGGGAACCTCACTTACGG
HK1 laA-200_3p CAGTGGTGATGACACAGAAGACTTTGTTGCTGGTGTGCCCAAAGGGAACCTCACTTACGG
HK1 laA-234_3p CAGTGGTGATGACACAGAAGACTTTGTTGCTGGTGTGCCCAAAGGGAACCTCACTTACGG
HK1 laA-7_3p CAGTGGTGATGACACAGAAGACTTTGTTGCTGGTGTGCCCAAAGGGAACCTCACTTACGG
HK1 laA-131_3p CAGTGGTGATGACACAGAAGACTTTGTTGCTGGTGTGCCCAAAGGGAACCTCACTTACGG
HKI laA-266_3p CAGTGGTGATGACACAGAAGACTTTGTTGCTGGTGTGCCCAAAGGGAACCTCACTTACGG

Contig8298622 CAGTGGTGATGACACAGAAGACTTTGTTGCTGGTGTGCCCAAAGGGAACCTCACTTACGG
HK1 laA-153_3p CTATGTCACCATCCTTAATGGCTCAGACATTCGATCCCTCTACAACTTCTCAGGGGAACA
HKI laA-140_3p CTATGTCACCATCCTTAATGGCTCAGACATTCGATCCCTCTACAACTTCTCAGGGGAACA
HK1 laA-1_3p CTATGTCACCATCCTTAATGGCTCAGACATTCGATCCCTCTACAACTTCTCAGGGGAACA
HKI laA-255_3p CTATGTCACCATCCTTAATGGCTCAGACATTCGATCCCTCTACAACTTCTCAGGGGAACA
HKI laA-279_3p CTATGTCACCATCCTTAATGGCTCAGACATTCGATCCCTCTACAACTTCTCAGGGGAACA
HK1 laA-24_3p CTATGTCACCATCCTTAATGGCTCAGACATTCGATCCCTCTACAACTTCTCAGGGGAACA
HKI laA-200_3p CTATGTCACCATCCTTAATGGCTCAGACATTCGATCCCTCTACAACTTCTCAGGGGAACA
HK1 laA-234_3p CTATGTCACCATCCTTAATGGCTCAGACATTCGATCCCTCTACAACTTCTCAGGGGAACA
HK1 laA-7_3p CTATGTCACCATCCTTAATGGCTCAGACATTCGATCCCTCTACAACTTCTCAGGGGAACA
HK1 laA-131_3p CTATGTCACCATCTTTAATGGCTCAGACATTCGATCCCTCTACAACTTCTCAGGGGAACA
HK1 1aA-266_3p CTATGTCACCATCCTTAATGGCTCAGACATTCGATCCCTCTACAACTTCTCAGGGGAACA
HK1 laA-168_3p TGGCTCAGACATTCGATCCCTTTACAACTTCTCAGGGGAACA

Contig8298622 CTATGTCACCATCCTTAATGGCTCAGACATTCGATCCCTCTACAACTTCTCAGGGGAACA
HK1 laA-153_3p GATGGCCTCCTACTTTGGCTATGCAGTGGCCGCCACAGACG
HK1 laA-140_3p GATGGCCTCCTACTTTGGCTATGCAGTGGCCGCCACAGACG
HK1 laA-1_3p GATGGCCTCCTACTTTGGCTATGCAGTGGCCGCCACAGACG
HKI laA-255_3p GATGGCCTCCTACTTTGGCTATGCAGTGGCCGCCACAGACG
HK1 laA-279_3p GATGGCCTCCTACTTTGGCTATGCAGTGGCCGCCACAGACG
HK1 laA-24_3p GATGGCCTCCTACTTTGGCTATGCAGTGGCCGCCACAGACG
HK1 laA-200_3p GATGGCCTCCTACTTTGGCTATGCAGTGGCCGCCACAGACGTCAATGGGGACGGGCTGGA
HK1 laA-234_3p GATGGCCTCCTACTTTGGCTATGCAGTGGCCGCCACAGACGTCAATGGGGACGGGCTGGA
HK1 laA-7_3p GATGGCCTCCTACTTTGGCTATGCAGTGGCCGCCACAGACGTCAATGGGGACGGGCTGGA
HK1 laA-131_3p GATGGCCTCCTACTTTGGCTATGCAGTGGCCGCCACAGACGTCAATGGGGACGGGCTGGA
HK1 laA-266_3p GATGGCCTCCTACTTTGGCTATGCAGTGGCCGCCACAGACGTCAATGGGGACGGGCTGGA
HK1 laA-168_3p GATGGCCTCCTACTTTGGCTATGCAGTGGCCGCCACAGACGTCAATGGGGACGGGCTGGA

Contig8298622 GATGGCCTCCTACTTTGGCTATGCAGTGGCCGCCACAGACGTCAATGGGGACGGGCTGGA
HKI laA-200_3p TGACTTGCTGGTGGGGGCACCCCTGCTCATGGATCGGACCCCTGACGGGCGGCCTCAGGA
HK1 laA-234_3p TGACTTGCTGGTGGGGGCACCCCTGCTCATGGATCGGACCCCTGACGGGCGGCCTCAGGA
HK1 laA-7_3p TGACTTGCTGGTGGGGGCACCCCTGCTCATGGATCGGACCCCTGACGGGCGGCCTCAGGA
HK1 laA-131_3p TGACTTGCTGGTGGGGGCACCCCTGCTCATGGATCGGACCCCTGACGGGCGGCCTCAGGA
HK1 laA-266_3p TGACTTGCTGGTGGGGGCACCCCTGCTCATGGATCGGACCCCTGACGGGCGGCCTCAGGA
HK1 laA-168_3p TGACTTAAAGGTGGGGGCACCCCTGCTCATGGATCGGACCCCTGACGGGCGGCCTCAGGA

Contig8298622 TGACTTGCTGGTGGGGGCACCCCTGCTCATGGATCGGACCCCTGACGGGCGGCCTCAGGA

Page 53 sur 136 HK1 laA-200_3p GGTGGGCAGGGTCTACGTCTACCTGCAGCACCCAGCCGGCATAGAGCCCACGCC
HK1 laA-234_3p GGTGGGCAGGGTCTACGTCTACCTGCAGCACCCAGCCGGCATAGAGCCCACGCCC
HK1 1aA-7_3p GGTGGGCAGGGTTTACGTCTACCTGCAGCACCCAGCCGGCATAGAGCCCACGCC
HK1 laA-1313p GGTGGGCAGGGTCTACGTCTACCTGCAGCACCCAGCCGGCATAGAGCCCACGCC
HK1 laA-2663p GGTGGGCAGGGTCTACGTCTACCTGCAGCACCCAGCCGGCATAGAGCCCACGCCC
HK1 laA-168_3p GGTGGGCAGGGTNTACGTCTACCTGCAGCACCCAGCCGGCATAGAGCCCACGCCC

Contig8298622 GGTGGGCAGGGTCTACGTCTACCTGCAGCACCCAGCCGGCATAGAGCCCACGCCC
Contig8298622 Consensus sequence >Contig8298622 1074 nt CGACCCCCGCTGCTGCCGCTGCTGTTGCTGCTGCTGCCGCCGCCACCCAGGGTCGGGGGCTTCAACTTAAACGCGGAGG
C
CCCAGCAGTACTCTCGGGGCCCCCGGGCTCCTTCTTCGGATTCTCAGTGGAGTTTTACCGGCCGGGAACAGACGGGGTC
A
GTGTGCTGGTGGGACCACCCAAGGCTAATACCACCCAGCCAGGAGTGCTGCAGGGTGGTGCTGTCTACCTCTGTCCTTG
G
GGTGCCACCCCCACACAGTGCACCCCCATTGAATTTGACAGCAAAGGCTCTCGGCTCCTGGAGTCCTCACTGTCCAGCT
C
AAAGGGAGAGGAGCCTGTGGAGTACAAGTCCTTGCAGTGGTTCGGGGCAACAGTTCGAGCCCATGGCTCCTCCATCTTG
G
CATGCGCTCCACTGTACAGCTGGCGCACAGAAAAGGAGCCACTGAGCGACCCCGTGGGCACCTGCTACCTCTACACAGA
T
AACTTCACCCGAATTCTGGAGTATGCACCCTGCCGCTCAGATTTCAGCTGGGCAGCAGGACAGGGTTACTGCCAAGGAG
G
CTTCAGTGCCGAGTTCACCAAGACTGGCCGTGTGGTTTTAGGTGGACCAGGAAGCTATTTCTGGCAAGGCCAGATCCTG
T
CTGCCACTCAGGAGCAGATTGCAGAATCTTATTACCCCGAGTACCTGATCAACCTGGTTCAGGGGCAGCTGCAGACTCG
C
CAGGCCAGTTCCATCTATGATGACAGCTACCTAGGATACTCTGTGGCTGTTGGTGAATTCAGTGGTGATGACACAGAAG
A
CTTTGTTGCTGGTGTGCCCAAAGGGAACCTCACTTACGGCTATGTCACCATCCTTAATGGCTCAGACATTCGATCCCTC
T
ACAACTTCTCAGGGGAACAGATGGCCTCCTACTTTGGCTATGCAGTGGCCGCCACAGACGTCAATGGGGACGGGCTGGA
T
GACTTGCTGGTGGGGGCACCCCTGCTCATGGATCGGACCCCTGACGGGCGGCCTCAGGAGGTGGGCAGGGTCTACGTCT
A
CCTGCAGCACCCAGCCGGCATAGAGCCCACGCCC

back to table Contig8298638 Alignment HK1 laA-77_5p CCGCCTCTGCTGCTGCTGCTGCTGCTGCCGCTGCTGCTGCACGAATCGTCGCACCCCCCA
HKI laA-8_5p CTGCTGCTGCTGCTGCTGCTGCCGCTGCTGCTGCACAAATCGTCGCACCCCCCA
HK1 laA-78_3p GCTGCTGCTGCTGCTGCTGCCGCTGCTGCTGCACGAATCGTCGCAGCCCCCA
HK1 1aA-78_5p CTGCTGCTGCTGCTGCTGCTGCCGCTGCTGCTGCACGAATCGTCGCAGCCCCCA
HKI laA-138_3p CTGCTGCTGCTGCTGCTGCTGCCGCTGCTGCTGCACGAATCGTCGCAGCCCCCA
HK1 laA-8_3p CTGCTGCTGCTGCTGCTGCTGCCGCTGCTGCTGCACGAATCGTCGCAGCCCCCA
HK1 laA-138_5p CTGCTGCTGCTGCTGCTGCTGCCGCTGCTGCTGCACGAATCGTCGCAGCCCCCA
HKI laA-123_5p CTGCTGCTGCTGCTGCTGCTGCCGCTGCTGCTGCACGAATCGTCGCAGCCCCCA
HK1 laA-67_5p TGCTGCTGCTGCTGCTGCCGCTGCTGCTGCACAAATCGTCGCAGCCCCCA
HKI laA-65_5p TGCTGCTGCTGCTGCTGCTGCCGCTGCTGCTGCACGAATCGTCGCAGCCCCCA
HK1 laA-58_5p CTGCTGCTGCTGCTGCTGCCGCTGCTGCTGCACGAATCGTCGCAGCCCCCA
HK1 laA-82_5p CTGCTGCTGCTGCTGCTGCCGCTGCTGCTGCACGAATCGTCGCACCCCCCA

Contig8298638 CCGCCTCTGCTGCTGCTGCTGCTGCTGCCGCTGCTGCTGCACGAATCGTCGCAGCCCCCA
HK1 laA-77_5p GCCTTGCGCGTCGTCGCTACCTCCTGGGACAGAAATTTTATGAATAAGCATCAAAA-GCC
HK1 laA-8_5p GCCTTGCGCGTCGTCGCTACCTCCTCGGACAGAATTTTTATGAATAAGCATCAAAA-GCC
HK1 laA-78_3p GCCTTGCGCGTCGTCGCTACCTCCTCGGACAGAAATTTTATGAATAAGCATCAGAA-GCC
HKI laA-78_5p GCCTTGCGCGTCGTCGCTACCTCCTCGGACAGAAATTTTATGAATAAGCATCAGAA-GCC
HK1 laA-138_3p GCCTTGCGCGTCGTCGCTACCTCCTCGGACAGAAATTTTATGAATAAGCATCAGAA-GCC
HK1 laA-8_3p GCCTTGCGCGTCGTCGCTACCTCCTCGGACAGAAATTTTATGAATAAGCATCAGAA-GCC
HK1 laA-138_5p GCCTTGCGCGTCGTCGCTACCTCCTCGGACAGAAATTTTATGAATAAGCATCAGAA-GCC
HK1 laA-123_5p GCCTTGCGCGTCGTCGCTACCTCCTCGGACAGAAATTTTATGAATAAGCATCAGAA-GCC
HK1 laA-67_5p GCCTTGCGCGTCGTCGCTACCTCCTCGGAAAGAAATTTTATGAATAAGCATCAGAAAGCC
HK1 laA-65_5p GCCTTGCGCGTCGTCGCTACCTCCTCGGACAGAAATTTTATGAATAAGCATCAGAA-GCC

Page 54 sur 136 HK1 laA-58_5p GCCTTGCGCGTCGTCGCTACCTCCTCGGACAGAAATTTTATGAATAAGCATCAAAA-GCC
HK1 1aA-82_5p GCCTTGCGCGTCGTCGCTACCTCCTCGGACAGAAATTTTATGAATAAGCATCAAAA-GCC

Contig8298638 GCCTTGCGCGTCGTCGCTACCTCCTCGGACAGAAATTTTATGAATAAGCATCAGAA-GCC
HK1 laA-77_5p AGTGCTAACAGGCCAGCGGTTCAAAACTCGGAAAAGGGATGAAAAAGAGAATTTCGAACC
HK1 laA-8_5p AGTGCTAACAGGCCAGCGGTTCAAAACTCGGAAAAGGGATGAAAAAGAGAAATTCGAACC
HK1 laA-78_3p AGTGCTAACAGGCCAGCGGTTCAAAACTCGGAAAAGGGATGAAAAAGAGAAATTCGAACC
HKI 1aA-78_5p AGTGCTAACAGGCCAGCGGTTCAAAACTCGGAAAAGGGATGAAAAAGAGAAATTCGAACC
HK1 laA-138_3p AGTGCTAACAGGCCAGCGGTTCAAAACTCGGAAAAGGGATGAAAAAGAGAAATTCGAACC
HK1 laA-8_3p AGTGCTAACAGGCCAGCGGTTCAAAACTCGGAAAAGGGATGAAAAAGAGAAATTCGAACC
HK1 laA-138_5p AGTGCTAACAGGCCAGCGGTTCAAAACTCGGAAAAGGGATGAAAAAGAGAAATTCGAACC
HK1 laA-123_5p AGTGCTAACAGGCCAGCGGTTCAAAACTCGGAAAAGGGATGAAAAAGAGAAATTCGAACC
HK1 laA-67_5p AGTGCTAACAGGCCAGCGGTTCAAAACTCGGAAAAGGGATGAAAAAGAGAATTTCGAACC
HK1 laA-65_5p AGTGCTAACAGGCCAGCGGTTCAAAACTCGGAP.AAGGGATGAAAAAGAGAATTTCGAACC
HK1 IaA-585p AGTGCTAACAGGCCAGCGGTTCAAAACTCGGAAAAGGGATGAAAAAGAGAATTTCGAACC
HK1 laA-82_5p AGTGCTAACAGGCCAGCGGTTCAAAACTCGGAAAAGGGATGAAAAAGAGAATTTCGAACC

Contig8298638 AGTGCTAACAGGCCAGCGGTTCAAAACTCGGAAAAGGGATGAAAAAGAGAAATTCGAACC
HK1 laA-77_5p CACATTCTTCAGGGATACACTTGTCCAGGGGCTTAATGAGGCTGGTGATGACCTTGAAGC
HK1 laA-8_5p CACAGTCTTCAGGGATACACTTGTCCAGGGGCTTAATGAGGCTGGTGATGACCTTGAAGC
HK1 1aA-783p CACAGTCTTCAGGGATACACTTGTCCAGGGGCTTAATGAGGCTGGTGATGACCTTGAAGC
HK1 laA-785p CACAGTCTTCAGGGATACACTTGTCCAGGGGCTTAATGAGGCTGGTGATGACCTTGAAGC
HK1 laA-138_3p CACAGTCTTCAGGGATACACTTGTCCAGGGGCTTAATGAGGCTGGTGATGACCTTGAAGC
HKI laA-8_3p CACAGTCTTCAGGGATACACTTGTCCAGGGGCTTAATGAGGCTGGTGATGACCTTGAAGC
HK1 laA-138_5p CACAGTCTTCAGGGATACACTTGTCCAGGGGCTTAATGAGGCTGGTGATGACCTTGAAGC
HK1 1aA-123_5p CACAGTCTTCAGGGATACACTTGTCCAGGGGCTTAATGAGGCTGGTGATGACCTTGAAGC
HK1 laA-67_5p CACAGTCTTCAGGGATACACTTGTCCAGGGGCTTAATGAGGCTGGTGATGACCTTGAAGC
HK1 laA-65_5p CACAGTCTTCAGGGATACACTTGTCCAGGGGCTTAATGAGGCTGGTGATGACCTTGAAGC
HK1 laA-58_5p CACAGTCTTCAGGGATACACTTGTCCAGGGGCTTAATGAGGCTGGTGATGACCTTGAAGC
HK1 laA-82_5p CACAGTCTTCAGGGATACACTTGTCCAGGGGCTTAATGAGGCTGGTGATGACCTTGAAGC

Contig8298638 CACAGTCTTCAGGGATACACTTGTCCAGGGGCTTAATGAGGCTGGTGATGACCTTGAAGC
HK1 laA-77_5p TGTACCCAAATTTCTGGACTCTACAGGCTCAAGATTATATTATCGTCGCTATGCAAACAC
HK1 laA-8_5p TGTAGCCAAATTTCTGGACTCTACAGGCTCAAGATTAGATTATCGTCGCTATGCAAACAC
HK1 laA-78_3p TGTAGCCAAATTTCTGGACTCTACAGGCTCAAGATTAGATTATCGTCGCTATGCAGACAC
HK1 laA-78_5p TGTAGCCAAATTTCTGGACTCTACAGGCTCAAGATTAGATTATCGTCGCTATGCAGACAC
HK1 laA-138_3p TGTAGCCAAATTTCTGGACTCTACAGGCTCAAGATTAGATTATCGTCGCTATGCAGACAC
HK1 laA-8_3p TGTAGCCAAATTTCTGGACTCTACAGGCTCAAGATTAGATTATCGTCGCTATGCAGACAC
HK1 laA-138_5p TGTAGCCAAATTTCTGGACTCTACAGGCTCAAGATTAGATTATCGTCGCTATGCAGACAC
HK1 laA-123_5p TGTAGCCAAATTTCTGGACTCTACAGGCTCAAGATTAGATTATCGTCGCTATGCAGACAC
HKI laA-67_5p TGTACCCAAATTTCTGGACTCTACAGGCTCAAGATTAGATTATCGTCGCTATGCAAACAC
HK1 laA-65_5p TGTAGCCAAATTTCTGGACTCTACAGGCTCAAGATTAGATTATCGTCGCTATGCAAACAC
HK1 laA-58_5p TGTAGCCAAATTTCTGGACTCTACAGGCTCAAGATTAGATTATCGTCGCTATGCAGACAC
HK1 laA-82_Sp TGTAGCCAAATTTCTGGACTCTACAGGCTCAAGATTAGATTATCGTCGCTATGCAAACAC
HK1 laA-67_3p ACAGGCTCAAGATTAGATTATCGTCGCTATGCAGACAC

Contig8298638 TGTAGCCAAATTTCTGGACTCTACAGGCTCAAGATTAGATTATCGTCGCTATGCAGACAC
HK1 laA-77_5p ACTCTTCAATATCCTGGTGGCTGGCAGTATGCTTGCCCCTGGAGGAACGCGCATAGATTA
HK1 laA-8_5p ACTCTTCGATATCCTGGTGGCTGGCAGTATGCTTGCCCCTGGAGGAACGCGCATAGATGA
HK1 1aA-78_3p ACTCTTCGATATCCTGGTGGCTGGCAGTATGCTTGCCCCTGGAGGAACGCGCATAGATGA
HK1 IaA-78_5p ACTCTTCGATATCCTGGTGGCTGGCAGTATGCTTGCCCCTGGAGGAACGCGCATAGATGA
HK1 laA-138_3p ACTCTTCGATATCCTGGTGGCTGGCAGTATGCTTGCCCCTGGAGGAACGCGCATAGATGA
HK1 laA-8_3p ACTCTTCGATATCCTGGTGGCTGGCAGTATGCTTGCCCCTGGAGGAACGCGCATAGATGA
HK1 laA-138_5p ACTCTTCGATATCCTGGTGGCTGGCAGTATGCTTGCCCCTGGAGGAACGCGCATAGATGA
HK1 1aA-123_5p ACTCTTCGATATCCTGGTGGCTGGCAGTATGCTTGCCCCTGGAGGAACGCGCATAGATGA
HK1 laA-67_5p ACTCTTCGATATCCTGGTGGCTGGCAGTATGCTTGCCCCTGGAGGAACGCGCATAGATGA

Page 55 sur 136 HK1 1aA-65_5p ACTCTTCAATATCCTGGTGGCTGGCAGTATGCTTGCCCCTGGAGGAACGCGCATAGATGA
HK1 1aA-58_5p ACTCTTCGATATCCTGGTGGCTGGCAGTATGCTTGCCCCTGGAGGAACGCGCATAGATGA
HK1 laA-82_5v ACTCTTCGATATCCTGGTGGCTGGCAGTATGCTTGCCCCTGGAGGAACGCGCATAGATGA
HK1 laA-67_3p ACTCTTCGATATCCTGGTGGCTGGCAGTATGCTTGCCCCTGGAGGAACGCGCATAGATGA

Contig8298638 ACTCTTCGATATCCTGGTGGCTGGCAGTATGCTTGCCCCTGGAGGAACGCGCATAGATGA
HK1 1aA-77_5p TGGTGACAAGACCAAGATGACCATCCCCTGTGTGTTTTCACCAAATGAAGATCATGAAAC
HK1 laA-8_5p TGGTGACAAGACCAAGATGACCATCC
HK1 laA-78_3p TGGTGACAAGACCAAGATGACCAACCACG
HK1 1aA-78_5p TGGTGACAAGACCAAGATGACCAACCACG
HK1 laA-138_3p TGGTGACAAGACCAAGATGACCAACCACG
HK1 1aA-8_3p TGGTGACAAGACCAAGATGACCAACCACG
HK1 1aA-138_5p TGGTGACAAGACCAAGATGACCAACCACG
HK1 1aA-123_5p TGGTGACAAGACCAAGATGACCAACCACTGTGTGTTTTCAG
HK1 1aA-67_5p TGGTGACAAGACCAAGATGACCAACCACTGTGTGTTTTCAGCAAATGAAGATCATGAAAC
HK1 1aA-655p TGGTGACAAGACCAAGATGACCAACCGCTGTGTGTTTTCAGCAAATGAAGATCATGAACC
HK1 laA-58_5p TGGTGACAAGACCAAGATGACCAACCACTGTGTGTTTTCAGCAAATGAAGATCATGAAAC
HK1 1aA-82_5p TGGTGACAAGACCAAGATGACCATCCTCTGTGTGTTTTCAGCAAATGAAGATCATGAAAC
HK1 laA-67_3p TGGTGACAAGACCAAGATGACCAACCACTGTGTGTTTTCAGCAAATGAAGATCATGAAAC

Contig8298638 TGGTGACAAGACCAAGATGACCAACCACTGTGTGTTTTCAGCAAATGAAGATCATGAAAC
HK1 laA-775p CCTCCGAAACTATGCTCAGGTCTTCAATAAACTCATCAGGAGATATAATTTTTGGGAGAA
HK1 laA-675p CATCCGAAACTA
HK1 1aA-65_5p CCTCC
HK1 laA-58_5p CCTCCGAAAC
HK1 laA-82_5p CATCCGAAACTATGCTCAGGTCTTCAATAAACTCATCAGGAGATATAAGTATTTGGAGGA
HK1 laA-67_3p CATCCGAAACTATGCTCAGGTCTTCAATAAACTCATCAGGAGATATAAGTATTTGGAGAA

Contig8298638 CATCCGAAACTATGCTCAGGTCTTCAATAAACTCATCAGGAGATATAAGTATTTGGAGAA
HK1 laA-77_5p GGCATTTGAAAATGAA
HK1 laA-82_Sp GGCATTTGAAGATGAA
HK1 1aA-67_3p GGCATTTGAAGATGAAATGAAAAAGCTTCTCCTCTTCCTTAAAGCCTTTTCCGAAACAGA
HK1 laA-129_3p TCTTCCTTAAAGCCTTTTCCGAAACAGA
HK1 laA-65_3p AGA

Contig8298638 GGCATTTGAAGATGAAATGAAAAAGCTTCTCCTCTTCCTTAAAGCCTTTTCCGAAACAGA
HK1 laA-67_3p GCAGACAAAGTTGGCGATGCTGTCGGGGATTCTGCTGGGCAATGGCACCCTGCCCGCCAC
HK1 laA-129_3p GCAGACAAAGTNGGCGATGCTGTCGGGGATTTTGNTGGGCAATGGCACCNTGCCCGCCAC
HK1 laA-77_3p GGGCAATGGCACCNTGNCCGCCAC
HK1 1aA-65_3p GCAGACAAAGTTGGCGATGCTGTCGGTGATTTTGCTGGGCAATGGCACCCTGCCCGCCAC
HK1 laA-123_3p GGGCAATGGCATCTTGNCCGCCAC

Contig8298638 GCAGACAAAGTTGGCGATGCTGTCGGGGATTTTGCTGGGCAATGGCACCCTGCCCGCCAC
HK1 laA-67_3p CATCCTCACCAGTCTTTTCACCGACAGCTTAGTCAAAGAAGGCATTGCGGCC
HK1 laA-129_3p CATCCTCACCAGTCTCTTCACCGACAGCTTAGTCAAAGAAGGCATTGCGGCCTCATTTGC
HK1 1aA-77_3p CATCCTCACCAGTCTCTTCACCGACAGCTTAGTCAAAGAAGGCATTGCGGCCTCATTTGC
HK1 1aA-65_3p CATCCTCACCAGTCTCTTCACCGACAGCTTAGTCAAAGAAGGCATTGCGGCCTCATTTGC
HK1 laA-123_3p CATCCTCACCAGTCTTTTCACCGACAGCTTAGTCAAAGAAGGCATTGCGGCCTCATTTGC

Contig8298638 CATCCTCACCAGTCTCTTCACCGACAGCTTAGTCAAAGAAGGCATTGCGGCCTCATTTGC
HK1 laA-129_3p TGTCAAGCTTTTCAAAGCATGGATGGCAGAAAAAGATGCCAACTCTGTTACCTCGTCTTT
HK1 laA-77_3p TGTCAAGCTTTTCAAAGCATGGATGGCAGAAAAAGATGCCAACTCTGTTACCTCGTCTTT

Page 56 sur 136 HK1 laA-65_3p TGTCAAGCTTTTCAAAGCATGGATGGCAGAAAAAGATGCCAACTCTGTTACCTCGTCTTT
HK1 laA-123_3p TGTCAAGCTTTTCAAAGCATGGATGGCAGAAAAAGATGC.CAACTCTGTTACCTCGTCTTT

Contig8298638 TGTCAAGCTTTTCAAAGCATGGATGGCAGAAAAAGATGCCAACTCTGTTACCTCGTCTTT
HK1 1aA-129_3p GAGAAAAGCCAACTTAGACAAGAGGCTGCTTGAACTCTTTCCAGTTAACAGACAGAGTGT
HK1 laA-77_3p GAGAAAAGCCAACTTAGACAAGAGGCTGCTTGAACTCTTTCCAGTTAACAGACAGAGTGT
HK1 laA-65_3p GAGAAAAGCCAACTTAGACAAGAGGCTGCTTGAACTCTTTCCAGTTAACAGACAGAGTGT
HK1 laA-123_3p GAGAAAAGCCAACTTAGACAAGAGGCTGCTTGAACTCTTTCCAGTTAACAGACAGAGTGT

Contig8298638 GAGAAAAGCCAACTTAGACAAGAGGCTGCTTGAACTCTTTCCAGTTAACAGACAGAGTGT
HK1 laA-129_3p GGATCATTTTGCTAAATACTTCACTGACGCAGGTCTTAAGGAGCTTTCCGACTTCCTCCG
HK1 laA-77+3p GGATCATTTTGCTAAATACTTCACTGACGCAGGTCTTAAGGAGCTTTCCGACTTCCTCCG
HK1 laA-653p GGATCATTTTGCTAAATACTTCACTGACGCAGGTCTTAAGGAGCTTTCCGACTTCCTCCG
HK1 laA-123_3p GGATCATTTTGCTAAATACTTCACTGACGCAGGTCTTAAGGAGCTTTCCGACTTCCTCCG

Contig829B638 GGATCATTTTGCTAAATACTTCACTGACGCAGGTCTTAAGGAGCTTTCCGACTTCCTCCG
HK1 laA-129_3p AGTCCAGCAGTCCCTGGGCACCAGGAAGGAACTGCAGAAGGAGCTCCAGGAGCGTCTTTC
HK1 laA-77_3p AGTCCAGCAGTCCCTGGGCACCAGGAAGGAACTGCAGAAGGAGCTCCAGGAGCGTCTTTC
HK1 laA-65_3p AGTCCAGCAGTCCCTGGGCACCAGGAAGGAACTGCAGAAGGAGCTCCAGGAGCGTCTTTC
HK1 1aA-123_3p AGTCCAGCAGTCCCTGGGCACCAGGAAGGAACTGCAGAAGGAGCTCCAGGAGCGTCTTTC

Contig8298638 AGTCCAGCAGTCCCTGGGCACCAGGAAGGAACTGCAGAAGGAGCTCCAGGAGCGTCTTTC
HK1 1aA-129_3p TCAGGAATGCCCGATCAAGGAGGTGGTGCTTTATGTCAAAGAAGAAATGAAGAGGAATGA
HK1 laA-77_3p TCAGGAATGCCCGATCAAGG
HK1 laA-65_3p TCAGGAATGCCCGATCAAGG
HK1 laA-123_3p TCAGGAATGCCCGATCAAGG

Contig8298638 TCAGGAATGCCCGATCAAGGAGGTGGTGCTTTATGTCAAAGAAGAAATGAAGAGGAATGA
HK1 laA-129_3p TCTTCCAGAAAC

Contig8298638 TCTTCCAGAAAC

Contig8298638 Consensus sequence >Contig8298638 971 nt CCGCCTCTGCTGCTGCTGCTGCTGCTGCCGCTGCTGCTGCACGAATCGTCGCAGCCCCCAGCCTTGCGCGTCGTCGCTA
C
CTCCTCGGACAGAAATTTTATGAATAAGCATCAGAAGCCAGTGCTAACAGGCCAGCGGTTCAAAACTCGGAAAAGGGAT
G
AAAAAGAGAAATTCGAACCCACAGTCTTCAGGGATACACTTGTCCAGGGGCTTAATGAGGCTGGTGATGACCTTGAAGC
T
GTAGCCAAATTTCTGGACTCTACAGGCTCAAGATTAGATTATCGTCGCTATGCAGACACACTCTTCGATATCCTGGTGG
C
TGGCAGTATGCTTGCCCCTGGAGGAACGCGCATAGATGATGGTGACAAGACCAAGATGACCAACCACTGTGTGTTTTCA
G
CAAATGAAGATCATGAAACCATCCGAAACTATGCTCAGGTCTTCAATAAACTCATCAGGAGATATAAGTATTTGGAGAA
G
GCATTTGAAGATGAAATGAAAAAGCTTCTCCTCTTCCTTAAAGCCTTTTCCGAAACAGAGCAGACAAAGTTGGCGATGC
T
GTCGGGGATTTTGCTGGGCAATGGCACCCTGCCCGCCACCATCCTCACCAGTCTCTTCACCGACAGCTTAGTCAAAGAA
G
GCATTGCGGCCTCATTTGCTGTCAAGCTTTTCAAAGCATGGATGGCAGAAAAAGATGCCAACTCTGTTACCTCGTCTTT
G
AGAAAAGCCAACTTAGACAAGAGGCTGCTTGAACTCTTTCCAGTTAACAGACAGAGTGTGGATCATTTTGCTAAATACT
T
CACTGACGCAGGTCTTAAGGAGCTTTCCGACTTCCTCCGAGTCCAGCAGTCCCTGGGCACCAGGAAGGAACTGCAGAAG
G
AGCTCCAGGAGCGTCTTTCTCAGGAATGCCCGATCAAGGAGGTGGTGCTTTATGTCAAAGAAGAAATGAAGAGGAATGA
T
CTTCCAGAAAC

Page 57 sur 136 (lhack tg table J
Contig8298647 Alignment HK1 laA-16_3p GTGTTGGTGCAGGGGGGGTCCATGCGCACTTTATCCCCTGAGCGCAGCAGTGCCTGATGC
HK1 1aA-40_3p GTGTTGGTGCAGGGGGGGTCCATGCGCACTTTATCCCCTGAGCGCAGCAGTGCCTGATGC

Contig8298647 GTGTTGGTGCAGGGGGGGTCCATGCGCACTTTATCCCCTGAGCGCAGCAGTGCCTGATGC
HK1 laA-16_3p CACATCCGCTTGAGTGGCAGGCGAGTGAAGATGTTGCCCAAATCCTGGACCACAACAGTG
HK1 laA-40_3p CACATCCGCTTGAGTGGCAGGCGAGTGAAGATGTTGCCCAAATCCTGGACCACAACAGTG

Contig8298647 CACATCCGCTTGAGTGGCAGGCGAGTGAAGATGTTGCCCAAATCCTGGACCACAACAGTG
HK1 laA-16_3p TCCTTCTCATACCTAAAATGGCTGGGCACCCCTCCAGCACACGGGGCATAGAGATTGTAG
HK1 laA-40_3p TCCTTCTCATACCTAAAATGGCTGGGCACCCCTCCAGCACACGGGGCATAGAGATTGTAG

Contig8298647 TCCTTCTCATACCTAAAATGGCTGGGCACCCCTCCAGCACACGGGGCATAGAGATTGTAG
HK1 laA-16_3p ATGTTGAGGCCAGAGTTGCCCACGATGCGGGCCACTTCCTGAAGATTGGTCACGCATTCC
HK1 laA-40_3p ATGTTGAGGCCAGAGTTGCCCACGATGCGGGCCACTTCCTGAAGATTGGTCACGCATTCC

Contig8298647 ATGTTGAGGCCAGAGTTGCCCACGATGCGGGCCACTTCCTGAAGATTGGTCACGCATTCC
HK1 laA-16_3p AGGTCTTTGTTGTCATAAAAGTTACACTTGTTTTGAGAGCAGCCAGTGGGTCTTGGAAAA
HK1 laA-40_3p AGGTCTTTGTTGTCATAAAAGTTACACTTGTTTTGAGAGCAGC-AGTGGGTCT-GGAGAG

Contig8298647 AGGTCTTTGTTGTCATAAAAGTTACACTTGTTTTGAGAGCAGCCAGTGGGTCTTGGAAAA
HK1 laA-16_3p AAAACCAAGACCTGTTCCCCAGAAGGCCCATGGTAGTA
HK1 laA-40_3p AAGACCAAAGCCTGTTCCCCAGAAGGCC-ATGGTAGTANGCAAAGTANACCAGGGAGTTG

Contig8298647 AAAACCAAAACCTGTTCCCCAGAAGGCCCATGGTAGTANGCAAAGTANACCAGGGAGTTG
HK1 laA-40_3p TCATTCTGCTCATANGAGGAGAGTCCATTGCCCACNGCCAGCCCCTGAAGGTTCATGCTG

Contig8298647 TCATTCTGCTCATANGAGGAGAGTCCATTGCCCACNGCCAGCCCCTGAAGGTTCATGCTG
HK1 laA-40_3p GGATCCTGCATCACCAGCACAGCCAGGGTGN

Contig8298647 GGATCCTGCATGACCAGCACAGCCAGGGTGN

Contig8298647 Consensus sequence >Contig8298647 451 nt GTGTTGGTGCAGGGGGGGTCCATGCGCACTTTATCCCCTGAGCGCAGCAGTGCCTGATGCCACATCCGCTTGAGTGGCA
G
GCGAGTGAAGATGTTGCCCAAATCCTGGACCACAACAGTGTCCTTCTCATACCTAAAATGGCTGGGCACCCCTCCAGCA
C
ACGGGGCATAGAGATTGTAGATGTTGAGGCCAGAGTTGCCCACGATGCGGGCCACTTCCTGAAGATTGGTCACGCATTC
C
AGGTCTTTGTTGTCATAAAAGTTACACTTGTTTTGAGAGCAGCCAGTGGGTCTTGGAAAAAAAACCAAAACCTGTTCCC
C
AGAAGGCCCATGGTAGTANGCAAAGTANACCAGGGAGTTGTCATTCTGCTCATANGAGGAGAGTCCATTGCCCACNGCC
A
GCCCCTGAAGGTTCATGCTGGGATCCTGCATGACCAGCACAGCCAGGGTGN

Page 58 sur 136 back to table Contig8298650 Alignment HK1 1aA-66_5p GCCACAATTGCCTTCTGCTGCTGCTGCTGCTGCAAGAGGAAAAGGACCCGGAACCCGGAC
HK1 1aA-42_5p TGCCATCTGCTGCTGCTGCTGCTGCAGGAGGAAAAGGAGCCGGAACCCGGAC
HK1 laA-66_3p TGCCATCTGCTGCTGCTGCTGCTGCAGGAGGAAGAGGAGCCGGAAGCCGGAC
HK1 laA-42_3p TGCCATCTGCTGCTGCTGCTGCTGCAGGAGGAAGAGGAGCCGGAAGCCGGAC
HK1 laA-277_5p TGCCATCTGCTGCTGCTGCTGCTGCAGGAGGAAGAGGAGCCGGAAGCCGGAC

Contig8298650 GCCACAATTGCCATCTGCTGCTGCTGCTGCTGCAGGAGGAAGAGGAGCCGGAAGCCGGAC
HK1 1aA-66--5p AGGTTTTGAGGAGAAGGCCATGTTTGAGCGGGAGGAAAGGCTGATCCGGCAGGATGACTG
HK1 laA-42_5p AGGAGT-GAGGAGAAGGCCATGCGTGACCGGGAGGAGAGGCGGATACGGCAGGAGGAACG
HK1 laA-66_3p AGGAGT-GAGGAGAAGGCCATGCGTGAGCGGGAGGAGAGGCGGATACGGCAGGAGGAACG
HK1 laA-42_3p AGGAGT-GAGGAGAAGGCCATGCGTGAGCGGGAGGAGAGGCGGATACGGCAGGAGGAACG
HK1 laA-277_5p AGGAGT-GAGGAGAAGGCCATGCGTGAGCGGGAGGAGAGGCGGATACGGCAGGAGGAACG

Contig8298650 AGGAGT-GAGGAGAAGGCCATGCGTGAGCGGGAGGAGAGGCGGATACGGCAGGAGGAACG
HK1 laA-66_5p GAA--CTAA-ATGAAAACAAGCACATGATGAAATCACAAAAATTTTTGGCCTGTTTAAAG
HK1 1aA-42_5p GAAAGCAAAGATGAAGACAGG-ACATGATGAAATCAGAAAAAATTATGGCCTGTTTAAAG
HK1 laA-66_3p GAGAGCAGAGATGAAGACAAG-ACATGATGAAATCAGAAAP.AAATATGGCCTGTTTAAAG
HK1 laA-42_3p GAGAGCAGAGATGAAGACAAG-ACATGATGAAATCAGAAP.AAAATATGGCCTGTTTAAAG
HK1 laA-277_5p GAGAGCAGAGATGAAGACAAG-ACATGATGAAATCAGAAAAAAATATGGCCTGTTTAAAG

Contig8298650 GAGAGCAGAGATGAAGACAAG-ACATGATGAAATCAGAAAAAAATATGGCCTGTTTAAAG
HK1 laA-66_5p AAAAAAACCCGTATGCTATTTTTGAAGACCACTAATGCGCTCCACCACATCATTCCCGAC
HK1 1aA-42_5p AAAAAAACCCGTATGCTATATTTGAAAACAACTAATGCGCTCCAGCACATCAGTCCCGAC
HK1 laA-66_3p AAGAAAACCCGTATGCTAGATTTGAAAACAACTAAAGCGCTCCAGCACATCAGTCCCGAC
HK1 laA-42_3p AAGAAAACCCGTATGCTAGATTTGAAAACAACTAAAGCGCTCCAGCACATCAGTCCCGAC
HK1 1aA-277_5p AAAAAAACCCGTATGCTAGATTTGAAAACAACTAAAGCGCTCCAGCACATCATTCCCGAC

Contig8298650 AAAAAAACCCGTATGCTAGATTTGAAAACAACTAAAGCGCTCCAGCACATCAGTCCCGAC
HK1 1aA-66_5p CCTTCGTGTGAGGTGCACACTCC
HK1 1aA-42_5p GCTTCCTGTGAGGTGCACACTCCGCAG
HK1 laA-66_3p GCTTCCTGTGAGGTGCACACTCCGCAG
HK1 1aA-42__3p GCTTCCTGTGAGGTGCACACTCCGCAG
HK1 laA-277_5p GCTTCCTGTGAGGTGCACACTCCGCAGCCCAGCCCAGCCGGGAGACCACGTGGCCTTTGC
HK1 laA-277_3p CGC

Contig8298650 GCTTCCTGTGAGGTGCACACTCCGCAGCCCAGCCCAGCCGGGAGACCACGTGGCCTTCGC
HK1 laA-277_5p GGTCTCCTGACCTTGGCCAGTGAACCTGCCAGCCTTCCAGGACAGGCGGCCGGAGAGCTG
HK1 1aA-277_3p GGTCTCCTGACCTTGGCCAGTGAACCTGCCAGCCTTCCAGGACAGGCGGCCGGAGAGCTG

Contig8298650 GGTCTCCTGACCTTGGCCAGTGAACCTGCCAGCCTTCCAGGACAGGCGGCCGGAGAGCTG
HK1 laA-277_5p CCCCTGAAGGACAGTCCTCTCGTCTTGCAAACTGGTGACCTTCTATTCCCTGTTCATCTC
HK1 laA-277_3p CCCCTGAAGGACAGTCCTCTCGTCTTGCAGACTGGTGACCTTCTATTCCCTGTTCATCTC

Contig8298650 CCCCTGAAGGACAGTCCTCTCGTCTTGCAAACTGGTGACCTTCTATTCCCTGTTCATCTC

Page 59 sur 136 HK1 laA-277_5p TGTTTCTAGATTTAGTCACTTGAAATAAGAAATCTTTGGGGTTTGGGCTTTTTTATACTC
HK1 laA-277_3p TGTTTCTAGATTTAGTCACTTGAAATAAGAAATCTTTGGGGTTTGGGCTTTTTTATACTC

Contig8298650 TGTTTCTAGATTTAGTCACTTGAAATAAGAAATCTTTGGGGTTTGGGCTTTTTTATACTC
HK1 laA-277_5p TTCTCAGTTTGTGAAACG
HK1 laA-277_3p TTCTCAGTTTGTGAAACGCTAACTGCACACGAAGCCGCCTGACGGCACCCAGCGCTGTGG

Contig8298650 TTCTCAGTTTGTGAAACGCTAACTGCACACGAAGCCGCCTGACGGCACCCAGCGCTGTGG
HK1 laA-277_3p CTGTCATTCTCCCAGGGCAGAACCCTGCGTTTCTCTCTGTCCACTAACAAGCTTCACACG

Contig8298650 CTGTCATTCTCCCAGGGCAGAACCCTGCGTTTCTCTCTGTCCACTAACAAGCTTCACACG
HK1 laA-277_3p CAACACAGGGAAGTCGGTTTGACTTTTGTCATGAGGAGAACTGACCAGCCCTCATCATTC

Contig8298650 CAACACAGGGAAGTCGGTTTGACTTTTGTCATGAGGAGAACTGACCAGCCCTCATCATTC
HK1 laA-277_3p CCCATAAAACCACGGACAGCGTCTGTGTGCGCATCTTGAGTCTTCACACCTGTTGACTCA

Contig8298650 CCCATAAAACCACGGACAGCGTCTGTGTGCGCATCTTGAGTCTTCACACCTGTTGACTCA
HK1 laA-277_3p CACGGCTTTTGCTGATGACACGG

Contig8298650 CACGGCTTTTGCTGATGACACGG

Contig8298650 Consensus sequence >Contig8298650 741 nt GCCACAATTGCCATCTGCTGCTGCTGCTGCTGCAGGAGGAAGAGGAGCCGGAAGCCGGACAGGAGTGAGGAGAAGGCCA
T
GCGTGAGCGGGAGGAGAGGCGGATACGGCAGGAGGAACGGAGAGCAGAGATGAAGACAAGACATGATGAAATCAGAAAA
A
AATATGGCCTGTTTAAAGAAAAAAACCCGTATGCTAGATTTGAAAACAACTAAAGCGCTCCAGCACATCAGTCCCGACG
C
TTCCTGTGAGGTGCACACTCCGCAGCCCAGCCCAGCCGGGAGACCACGTGGCCTTCGCGGTCTCCTGACCTTGGCCAGT
G
AACCTGCCAGCCTTCCAGGACAGGCGGCCGGAGAGCTGCCCCTGAAGGACAGTCCTCTCGTCTTGCAAACTGGTGACCT
T
CTATTCCCTGTTCATCTCTGTTTCTAGATTTAGTCACTTGAAATAAGAAATCTTTGGGGTTTGGGCTTTTTTATACTCT
T
CTCAGTTTGTGAAACGCTAACTGCACACGAAGCCGCCTGACGGCACCCAGCGCTGTGGCTGTCATTCTCCCAGGGCAGA
A
CCCTGCGTTTCTCTCTGTCCACTAACAAGCTTCACACGCAACACAGGGAAGTCGGTTTGACTTTTGTCATGAGGAGAAC
T
GACCAGCCCTCATCATTCCCCATAAAACCACGGACAGCGTCTGTGTGCGCATCTTGAGTCTTCACACCTGTTGACTCAC
A
CGGCTTTTGCTGATGACACGG

back to table Contig8298655 Alignment HK1 laA-272_3p CCCTGCTGGGGCAGAGGCCAAGCCAGAGCCCTGGCCCCATCACCTCTCTGCCCTGCTTGA
HKl laA-272_5p CGGGGCAGGGGCCAAGCCAGAGCCCTGGCCCCATCACCTCTCTTCCCTGCTTAT

Contig8298655 CCCTGCCGGGGCAGAGGCCAAGCCAGAGCCCTGGCCCCATCACCTCTCTGCCCTGCTTAA
HK1 1aA-272_3p GTCTGGAATGGACCTCCCTGCCTGGAAGCTGCATTGCCCTTGGTCCTGGGCCTGCCTGCC

Page 60 sur 136 HK1 laA-272_5p GTTTGGAATGGACCTCCCTGCCTGGAAGATGCATTGCCCTTGGTCCTGGGCTTGCCTGCC

Contig8298655 GTCTGGAATGGACCTCCCTGCCTGGAAGATGCATTGCCCTTGGTCCTGGGCCTGCCTGCC
HK1 1aA-272_3p CCCTGGGGAACACAGGCAGCAGCCACATTGGCAGTGAAGCCGTGGCAGCGTCNGCAGCAG
HK1 laA-272-5p CCCTGGGGAACACAGGCAGCAGCCACATTGGCAGTGAAACCGTGGCAGGGTCGGCAGCAG

Contig8298655 CCCTGGGGAACACAGGCAGCAGCCACATTGGCAGTGAAACCGTGGCAGCGTCGGCAGCAG
HK1 laA-272_3p AGGATGCCCCANGCCCTGNAGCGTGCANATGGCAGCTGGGCCCTGGGTGGTGCTGCTGGG
HK1 laA-272-5p AGGATGCCCCAGGCCCTGGAGCGTGCAGATGGCAGCTGGGCC-TGGGTGGTGTTGTTGGC

Contig8298655 AGGATGCCCCAGGCCCTGGAGCGTGCAGATGGCAGCTGGGCCCTGGGTGGTGCTGCTGGC
HK1 laA-272_3p CACCATGGTGACCCAAGGGCCTCCCCCCTGGGCCTTTCCCCACTTGTTTCGGCCCCCTTT
HK1 laA-272-5p CACCATGGTGACCCA-GGGCCTCACCCTGGGG --- TTCCCCACGTGGATTGGCA ---TTT

Contig8298655 CACCATGGTGACCCAAGGGCCTCACCCCGGGGCCTTTCCCCACGTGGATCGGCACCCTTT
HK1 1aA-272_3p TTTTCCTTGAACTTGCATGGGATTTTCCAGGGCACAAAACCCGAGAACCCTTTGGTTCCC
HK1 laA-272_5p TTTTCACTGAAATGCAATGGGAGTT-CCAGGCCAGCAACAGCGAGACCTCTT-GGTTCCC

Contig8298655 TTTTCACTGAAATGCAATGGGAGTTTCCAGGCCACAAAAACCGAGAACCCTTTGGTTCCC
HK1 laA-272_3p CCCCACCCCCACGGGTGTGTTCCCCCAAAGGGG
HK1 laA-272-5p CTCCATCCTCACGGCTGTGCTCCACATGGCAGGGCCCCTGTGCAGCATCCTGGTGGGACG

Contig8298655 CCCCACCCCCACGGCTGTGCTCCACAAAACAGGGCCCCTGTGCAGCATCCTGGTGGGACG
HK1 1aA-272_5p CTTTGGCTGCCGAGTGACCGTGATGTGGGGGGCGTGCTGGCCAGCCTGGGCATGGTGGCC

Contig8298655 CTTTGGCTGCCGAGTGACCGTGATGTGGGGGGCGTGCTGGCCAGCCTGGGCATGGTGGCC
HK1 laA-272_5p AGGTCCTTTTTTCACAACCTCAGCCAGCCCG

Contig8298655 AGGTCCTTTTTTCACAACCTCAGCCAGCCCG

Contig8298655 Consensus sequence >Contig8298655 511 nt CCCTGCCGGGGCAGAGGCCAAGCCAGAGCCCTGGCCCCATCACCTCTCTGCCCTGCTTAAGTCTGGAATGGACCTCCCT
G
CCTGGAAGATGCATTGCCCTTGGTCCTGGGCCTGCCTGCCCCCTGGGGAACACAGGCAGCAGCCACATTGGCAGTGAAA
C
CGTGGCAGCGTCGGCAGCAGAGGATGCCCCAGGCCCTGGAGCGTGCAGATGGCAGCTGGGCCCTGGGTGGTGCTGCTGG
C
CACCATGGTGACCCAAGGGCCTCACCCCGGGGCCTTTCCCCACGTGGATCGGCACCCTTTTTTTCACTGAAATGCAATG
G
GAGTTTCCAGGCCACAAAAACCGAGAACCCTTTGGTTCCCCCCCACCCCCACGGCTGTGCTCCACAAAACAGGGCCCCT
G
TGCAGCATCCTGGTGGGACGCTTTGGCTGCCGAGTGACCGTGATGTGGGGGGCGTGCTGGCCAGCCTGGGCATGGTGGC
C
AGGTCCTTTTTTCACAACCTCAGCCAGCCCG

back to table Contig8298657 Alignment Page 61 sur 136 HK1 laA-216_5p AGAGCGGNCCCCAGACCGGCGAAAAGACAAGAGAAGT

Contig8298657 AGAGCGGNCCCCAGACCGGCGAAAAGACAAGAGAAGT

Contig8298657 Consensus sequence >Contig8298657 37 nt AGAGCGGNCCCCAGACCGGCGAAAAGACAAGAGAAGT
back to table Contig8298659 Alignment HK1 laA-112_5p GGCTCCGGGTCACTGCCACTGCCACCGCTGCCACTGCCCCTGCTGCCAAGGGACAAGGGG
HK1 laA-174_5p GGCTCCGGGTCACTGCCACTGCCACCGCTGCCACTGCCCCTGCTGCCAAGGGACAAGGGG

Contig8298659 GGCTCCGGGTCACTGCCACTGCCACCGCTGCCACTGCCCCTGCTGCCAAGGGACAAGGGG
HK1 laA-112_5p CTGCTCTGGAAAGGTGAGCCAGCATCCGAGGGGGGTGGGGTCAGTGTGTCCTCCACCTCA
HK1 laA-174_5p CTGCTCTGGAAAGGTGAGCCAGCATCCGAGGGGGGTGGGGTCAGTGTGTCCTCCACCTCA
HK1 laA-174_3p CTGCTCTGGAAAGGTGAGCCAGCATCCGAGGGGGGTGGGGTCAGTGTGTCCTCCACCTCA
HK1 laA-112_3p CTGCTCTGGAAAGGTGAGCCAGCATCCGAGGGGGGTGGGGTCAGTGTGTCCTCCACCTCA

Contig8298659 CTGCTCTGGAAAGGTGAGCCAGCATCCGAGGGGGGTGGGGTCAGTGTGTCCTCCACCTCA
HK1 laA-112-_5p GTCTTCACGCCCTCCATGAGCACGTCTGTGTTCCCTCCACTGCCACAGGCCGACACCAGA
HK1 laA-174_5p GTCTTCACGCCCTCCATGAGCACGTCTGTGTTCCCTCCACTGCCACAGGCCGACACCAGA
HK1 laA-174_3p GTCTTCACGCCCTCCATGAGCACGTCTGTGTTCCCTCCACTGCCACAGGCCGACACCAGA
HK1 laA-112_3p GTCTTCACGCCCTCCATGAGCACGTCTGTGTTCCCTCCACTGCCACAGGCCGACACCAGA

Contig8298659 GTCTTCACGCCCTCCATGAGCACGTCTGTGTTCCCTCCACTGCCACAGGCCGACACCAGA
HK1 laA-112_5p TCCTTCAGAGATTTGCTTTTGTGGACAGCAGTGCGCAGACTTAGGTTCTCCTGCTTGAGT
HK1 SaA-174_5p TCCTTCAGAGATTTGCTTTTGTGGACAGCAGTGCGCAGACTTAGGTTCTCCTGCTTGAGT
HK1 laA-174_3p TCCTTCAGAGATTTGCTTTTGTGGACAGCAGTGCGCAGACTTAGGTTCTCCTGCTTGAGT
HK1 laA-112_3p TCCTTCAGAGATTTOCTTTTGTGGACAGCAGTGCGCAGACTTAGGTTCTCCTGCTTGAGT
HK1 1aA-221_3p GCGCAGACTTAGGTTCTCCTGCTTGAGT

Contig8298659 TCCTTCAGAGATTTGCTTTTGTGGACAGCAGTGCGCAGACTTAGGTTCTCCTGCTTGAGT
HK1 laA-112_5p TTCTGGTTGCTGTGTTGCAGAAAGCGAATGTAGTCGATGGCCTTGCGCAAGACAGCAGAT
HK1 laA-174_5p TTCTGGTTGCTGTGTTGCAGAAAGCGAATGTAGTCGATGGCCTTGCGCAAGACAGCAGAT
HK1 laA-174_3p TTCTGGTTGCTGTGTTGCAGAAAGCGAATGTAGTCGATGGCCTTGCGCAAGACAGCAGAT
HK1 laA-112_3p TTCTGGTTGCTGTGTTGCAGAAAGCGAATGTAGTCGATGGCCTTGCGCAAGACAGCAGAT
HK1 laA-221_3p TTCTGGTTGCTGTGTTGCAGAAAGCGAATGTAGTCGATGGCCTTGCGCAAGACAGCAGAT

Contig8298659 TTCTGGTTGCTGTGTTGCAGAAAGCGAATGTAGTCGATGGCCTTGCGCAAGACAGCAGAT
HK1 laA-112_5p TTATTCAGCTTTGCCTCAGTGCCCACCACCAGATCCTTGAGCTCAATGATTTTGTCATTG
HK1 laA-174_5p TTATTCAGCTTTGCCTCAGTGCCCACCACCAGATCCTTGAGCTCAATGATTTTGTCATTG
HK1 1aA-174_3p TTATTCAGCTTTGCCTCAGTGCCCACCACCAGATCCTTGAGCTCAATGATTTTGTCATTG

Page 62 sur 136 HK1 laA-112_3p TTATTCAGCTTTGCCTCAGTGCCCACCACCAGATCCTTGAGCTCAATGATTTTGTCATTG
HK1 laA-221-3p TTATTCAGCTTTGCCTCAGTGCCCACCACCAGATCCTTGAGCTCAATGATTTTGTCATTG

Contig8298659 TTATTCAGCTTTGCCTCAGTGCCCACCACCAGATCCTTGAGCTCAATGATTTTGTCATTG
HK1 laA-112_5p ATGGAGGAGCGGTAGCGCTTCTCAATGGCGTTGTGGGCTGTGCGCT
HK1 laA-174_5p ATGGAGGAGCGGTAGCGCTTCTCAATGGCGTTGTGGGCTGTGC
HK1 laA-174_3p ATGGAGGAGCGGTAGCGCTTCTCAATGGCGTTGTGGGCTGTGCGCTTCTCTCCACGGCTC
HK1 laA-112_3p ATGGAGGAGCGGTAGCGCTTCTCAATGGCGTTGTGGGCTGTGCGCTTCTCTCCACGGCTC
HK1 laA-221_3p ATGGAGGAGCGGTAGCGCTTCTCAATGGCGTTGTGGGCTGTGCGCTTCTCTCCACGGCTC

Contig8298659 ATGGAGGAGCGGTAGCGCTTCTCAATGGCGTTGTGGGCTGTGCGCTTCTCTCCACGGCTC
HK1 laA-174_3p TGGGCAGAGGCCGGGGCCTTGCTGCCAGCTGCGAGCCGGTTGATAGGCAGCTTCTCCGCA
HK1 laA-112-3p TGGGCAGAGGCCGGGGCCTTGCTGCCAGCTGCGAGCCGGTTGATAGGCAGCTTCTCCGCA
HK1 laA-221-3p TGGGCAGAGGCCGGGGCCTTGCTGCCAGCTGCGAGCCGGTTGATAGGCAGCTTCTCCGCA

Contig8298659 TGGGCAGAGGCCGGGGCCTTGCTGCCAGCTGCGAGCCGGTTGATAGGCAGCTTCTCCGCA
HK1 laA-174_3p TCTACGACCAGTGGGACTGTTGCCAAGA
HK1 laA-112_3p TCTACGACCAGTGGGACTGTTGCCAAGA
HK1 laA-221-3p TCTACGACCAGTGGGACTGTTGCCAAGATGGTTCCGCCACTCACCAGGGTCGGCAAAGGC

Contig8298659 TCTACGACCAGTGGGACTGTTGCCAAGATGGTTCCGCCACTCACCAGGGTCGGCAAAGGC
HK1 laA-221-3p CCTGTCTGCACAGTGGTGCCAGAGACCAGGGGACTGAGACCTGCCGCCTTCACAGTGGCT

Contig8298659 CCTGTCTGCACAGTGGTGCCAGAGACCAGGGGACTGAGACCTGCCGCCTTCACAGTGGCT
HK1 laA-221-3p CCGTCTGTCTTCATGGCTGTCAGAAGCAGCGAGTCTGCCTTGATGAAGTGGGGCTGCAGC

Contig8298659 CCGTCTGTCTTCATGGCTGTCAGAAGCAGCGAGTCTGCCTTGATGAAGTGGGGCTGCAGC
HK1 laA-221_3p AGGACCG

Contig8298659 AGGACCG

Contig8298659 Consensus sequence >Contig8298659 667 nt GGCTCCGGGTCACTGCCACTGCCACCGCTGCCACTGCCCCTGCTGCCAAGGGACAAGGGGCTGCTCTGGAAAGGTGAGC
C
AGCATCCGAGGGGGGTGGGGTCAGTGTGTCCTCCACCTCAGTCTTCACGCCCTCCATGAGCACGTCTGTGTTCCCTCCA
C
TGCCACAGGCCGACACCAGATCCTTCAGAGATTTGCTTTTGTGGACAGCAGTGCGCAGACTTAGGTTCTCCTGCTTGAG
T
TTCTGGTTGCTGTGTTGCAGAAAGCGAATGTAGTCGATGGCCTTGCGCAAGACAGCAGATTTATTCAGCTTTGCCTCAG
T
GCCCACCACCAGATCCTTGAGCTCAATGATTTTGTCATTGATGGAGGAGCGGTAGCGCTTCTCAATGGCGTTGTGGGCT
G
TGCGCTTCTCTCCACGGCTCTGGGCAGAGGCCGGGGCCTTGCTGCCAGCTGCGAGCCGGTTGATAGGCAGCTTCTCCGC
A
TCTACGACCAGTGGGACTGTTGCCAAGATGGTTCCGCCACTCACCAGGGTCGGCAAAGGCCCTGTCTGCACAGTGGTGC
C
AGAGACCAGGGGACTGAGACCTGCCGCCTTCACAGTGGCTCCGTCTGTCTTCATGGCTGTCAGAAGCAGCGAGTCTGCC
T
TGATGAAGTGGGGCTGCAGCAGGACCG

back to table Page 63 sur 136 Contig8298663 Alignment HK1 laA-190_3p ACCCCTCTCCTCATCTTCAGATTTGTCCNCTTTNNTTTCTCCCNCCTCTCCNCNCTCGCN

Contig8298663 ACCCCTCTCCTCATCTTCAGATTTGTCCNCTTTNNTTTCTCCCNCCTCTCCNCNCTCGCN
HK1 laA-190_3p NNNCCCCGCCCGCNTGTCCNTTTCCCGCCGCCCTNTTCTCACCCCCCCNCCTCTCCCCCC

Contig8298663 NNNCCCCGCCCGCNTGTCCNTTTCCCGCCGCCCTNTTCTCACCCCCCCNCCTCTCCCCCC
HK1 laA-190l3p CGCCCCCNNCCCTCTCGCCCCTNNNCCCCCGCGGGCACCCCCTCCCCCCCCCGCCTCAGA

Contig8298663 CGCCCCCNNCCCTCTCGCCCCTNNNCCCCCGCGGGCACCCCCTCCCCCCCCCGCCTCAGA
HK1 laA-190_3p ANCNGNCCGAACCCAATCCACCCCGGCACCGCAGACCCNGCAGGGACNTTTTTTTTTGTT

Contig8298663 ANCNGNCCGAACCCAATCCACCCCGGCACCGCAGACCCNGCAGGGACNTTTTTTTTTGTT
HK1 laA-190_3p TTTATATGTTACCCCCCATCTCCCANAATCAATATATCACCAAGAGTNGGGGGGGGGGGC

Contig8298663 TTTATATGTTACCCCCCATCTCCCANAATCAATATATCACCAAGAGTNGGGGGGGGGGGC
HK1 laA-190_3p TNTGATTTCCCCCCCGCCTTTCTGGGTGTGGTTTTGTGGGCTCCGAGAAAAAAAAAAAAA

Contig8298663 TNTGATTTCCCCCCCGCCTTTCTGGGTGTGGTTTTGTGGGCTCCGAGAAAAAAAAAAAAA
HK1 laA-190_3p TGAACCAGTGGGGGCAGGTCCCTCCAACCACCAGCACTGACTCCTGGGCTCTGAAGAATC

Contig8298663 TGAACCAGTGGGGGCAGGTCCCTCCAACCACCAGCACTGACTCCTGGGCTCTGAAGAATC
HK1 laA-190_3p ACAGAAACACTTTTTATATAAAATAAAATTATACCTAGC

Contig8298663 ACAGAAACACTTTTTATATAAAATAAAATTATACCTAGC
Contig8298663 Consensus sequence >Contig8298663 459 nt ACCCCTCTCCTCATCTTCAGATTTGTCCNCTTTNNTTTCTCCCNCCTCTCCNCNCTCGCNNNNCCCCGCCCGCNTGTCC
N
TTTCCCGCCGCCCTNTTCTCACCCCCCCNCCTCTCCCCCCCGCCCCCNNCCCTCTCGCCCCTNNNCCCCCGCGGGCACC
C
CCTCCCCCCCCCGCCTCAGAANCNGNCCGAACCCAATCCACCCCGGCACCGCAGACCCNGCAGGGACNTTTTTTTTTGT
T
TTTATATGTTACCCCCCATCTCCCANAATCAATATATCACCAAGAGTNGGGGGGGGGGGCTNTGATTTCCCCCCCGCCT
T
TCTGGGTGTGGTTTTGTGGGCTCCGAG TGAACCAGTGGGGGCAGGTCCCTCCAACCACCAGCACTGA
CTCCTGGGCTCTGAAGAATCACAGAAACACTTTTTATATAAAATAAAATTATACCTAGC
back to table Contig8298665 Alignment HK1 1aA-238_3p AGAGGCCACTCAATGCAAAACACAGAGCTGGCAGCCTGACAGGTGAGTTTCCTGTGTGGG
HK1 laA-125_3p AGAGGCCACTCAATGCAAAACACAGAGCTGGCAGCCTGACAGGTGAGTTTCCTGTGTGGG

Page 64 sur 136 HK1 laA-92-3p AGAGGCCACTCAATGCAAAACACAGAGCTGGCAGCCTGACAGGTGAGTTTCCTGTGTGGG

Contig8298665 AGAGGCCACTCAATGCAAAACACAGAGCTGGCAGCCTGACAGGTGAGTTTCCTGTGTGGG
HK1 laA-238_3p AGGCACACAGACAGACCTAGGGCAGCCGGTGGTGGGGAGGTTATGCTTGAAGCTGGGTTG
HK1 laA-125_3p AGGCACACAGACAGACCTAGGGCAGCCGGTGGTGGGGAGGTTATGCAGGAAGCTGGGTTG
HK1 laA-92-3p AGGCACACAGACAGACCTAGGGCAGCCGGTGGTGGGGAGGTTATGCATGAAGCTGGGTTG

Contig8298665 AGGCACACAGACAGACCTAGGGCAGCCGGTGGTGGGGAGGTTATGCATGAAGCTGGGTTG
HK1 1aA-238_3p GATGGGGACATTGACCAGTCANTCTGACCTTGCTAACTGTAAGGCCACCCCCTCAAGCTA
HK1 1aA-125_3p GATGGGGACATTGACCAGTCAGTCTGACCTTGCTAACTGTAAGGCCACAGCCTCAAGCTA
HK1 laA-92-3p GATGGGGACATTGNNNAGTNAGTNTGAGGTTGGTAANTGTAAGGCCACCCCCNNNNGCTA

Contig8298665 GATGGGGACATTGACCAGTCAGTCTGACCTTGCTAACTGTAAGGCCACCCCCTCAAGCTA
HK1 laA-238_3p CCTCCCTTCCCTCCTGCANCTACCCTGCACCTGAAGGTTCATGCAGAGATCCTGCATGAC
HK1 laA-125_3p CCTCCCTTCCCTCCTGCAGCTACCCTGCACCTGAAGGTTCAAGCTGGGATCCTGCATGAC
HK1 laA-92-3p CNNNNNTTNNNNCCTGCAGCTACCCTGCACCTGAAGGTTCATGCAAAAP.ACCTGCATGAC

Contig8298665 CCTCCCTTCCCTCCTGCAGCTACCCTGCACCTGAAGGTTCATGCAGAGATCCTGCATGAC
HK1 laA-238_3p CAGCACGGCCAGGGTGGGGATGTAGATGCCACCATAGCTCTCCACGGTCAGGAAAATTTT
HK1 laA-125_3p CAGCACGGCCAGGGTGGGGATGTATATGCC
HK1 laA-92_3p CNGCACGGCCAGGGTGGGGATGTANATGCCACCATANCTTTCCAANNNAAGGAAAAGTTT

Contig8298665 CAGCACGGCCAGGGTGGGGATGTAGATGCCACCATAGCTCTCCAAGGTAAGGAAAAGTTT
HK1 1aA-238_3p GTTGTTCATGCACTCCCGAAAGAAGCGGAAGA
HK1 laA-92_3p GTGGTTATTAGANACGGGGGAGGGGGGGAGAAAGCTTGGAGGGGCGGCAGAGAGAGCGGG

Contig8298665 GTGGTTAATACACACCCGAAAGAAGCGGAAAAAGCTTGGAGGGGCGGCAGAGAGAGCGGG
HK1 laA-92_3p GGAGACACAGTGGCGCGAGACGCGGACGACTGGACGGGAGGGGAAGAGANGCCGGCAGAA

Contig8298665 GGAGACACAGTGGCGCGAGACGCGGACGACTGGACGGGAGGGGAAGAGANGCCGGCAGAA
HK1 laA-92_3p GGGAGGAGAACACCCAAAGGGGGAGGAAGGAAAACAAAGGCGGGGGATGGG

Contig8298665 GGGAGGAGAACACCCAAAGGGGGAGGAAGGAAAACAAAGGCGGGGGATGGG
Contig8298665 Consensus sequence >Contig8298665 471 nt AGAGGCCACTCAATGCAAAACACAGAGCTGGCAGCCTGACAGGTGAGTTTCCTGTGTGGGAGGCACACAGACAGACCTA
G
GGCAGCCGGTGGTGGGGAGGTTATGCATGAAGCTGGGTTGGATGGGGACATTGACCAGTCAGTCTGACCTTGCTAACTG
T
AAGGCCACCCCCTCAAGCTACCTCCCTTCCCTCCTGCAGCTACCCTGCACCTGAAGGTTCATGCAGAGATCCTGCATGA
C
CAGCACGGCCAGGGTGGGGATGTAGATGCCACCATAGCTCTCCAAGGTAAGGAAAAGTTTGTGGTTAATACACACCCGA
A
AGAAGCGGAAAAAGCTTGGAGGGGCGGCAGAGAGAGCGGGGGAGACACAGTGGCGCGAGACGCGGACGACTGGACGGGA
G
GGGAAGAGANGCCGGCAGAAGGGAGGAGAACACCCAAAGGGGGAGGAAGGAAAACAAAGGCGGGGGATGGG
back to table Page 65 sur 136 Contig8298669 Alignment HK1 laA-247_5p GGAAAAGACAGCCCCTGCCGTGGTCTATATCGAGATCCTGGACCGGCACCCTTTCTTGGG

Contig8298669 GGAAAAGACAGCCCCTGCCGTGGTCTATATCGAGATCCTGGACCGGCACCCTTTCTTGGG
HK1 laA-247_5p CCGCGAGGTCCCTATCTCGAACGGCTCAGGATTCGTGGTGGCTGCCGATGGGCTCATTGT

Contig8298669 CCGCGAGGTCCCTATCTCGAACGGCTCAGGATTCGTGGTGGCTGCCGATGGGCTCATTGT
HK1 laA-247_5p CACCAACGCCCATGTGGTGGCTGATCGGCGCAAATTCCGTGTGAGACTGCTAAGCGGCGA

Contig8298669 CACCAACGCCCATGTGGTGGCTGATCGGCGCAAATTCCGTGTGAGACTGCTAAGCGGCGA
HK1 1aA-247_5p CACGTATGAGGCCGTGTTCACAGCTGTGGATCCCGGGCCAAAAATCCCAACCCTTAAGGA

Contig8298669 CACGTATGAGGCCGTGTTCACAGCTGTGGATCCCGGGCCAAAAATCCCAACCCTTAAGGA
HK1 1aA-247_5p TTAAA.A.AAAAAGAACCCCCCCCCCCCCCCCCCCCTGGGACCCCTCAACTTATTTTCCGGA

Contig8298669 TTAAAAAAAAAGAACCCCCCCCCCCCCCCCCCCCTGGGACCCCTCAACTTATTTTCCGGA
HK1 laA-247_5p CAGGGGATTTTTTTTTTTTTCCCAAGAAAAACCCCCTTTGCCACAAAAAAAAACATTTCC

Contig8298669 CAGGGGATTTTTTTTTTTTTCCCAAGAAAAACCCCCTTTGCCACAAAAAAAAACATTTCC
HK1 laA-247_5p CTTCCCGGGTTTTTTTTCCCCCCCCCCAAAAGGCCCCACAACAAAAAACCGGGGATCCCC

Contig8298669 CTTCCCGGGTTTTTTTTCCCCCCCCCCAAAAGGCCCCACAACAAAAAACCGGGGATCCCC
HK1 1aA-247_5p CCCAAAAAAAAATGGTGAAAATCCCCCCCCACCCCGGGGCACACTTT

Contig8298669 CCCAAAAAAAAATGGTGAAAATCCCCCCCCACCCCGGGGCACACTTT
Contig8298669 Consensus sequence >Contig8298669 467 nt GGAAAAGACAGCCCCTGCCGTGGTCTATATCGAGATCCTGGACCGGCACCCTTTCTTGGGCCGCGAGGTCCCTATCTCG
A
ACGGCTCAGGATTCGTGGTGGCTGCCGATGGGCTCATTGTCACCAACGCCCATGTGGTGGCTGATCGGCGCAAATTCCG
T
GTGAGACTGCTAAGCGGCGACACGTATGAGGCCGTGTTCACAGCTGTGGATCCCGGGCCAAAAATCCCAACCCTTAAGG
A
TTAAAAAAAAAGAACCCCCCCCCCCCCCCCCCCCTGGGACCCCTCAACTTATTTTCCGGACAGGGGATTTTTTTTTTTT
T
CCCAAGAAAAACCCCCTTTGCCACAAAAAAAAACATTTCCCTTCCCGGGTTTTTTTTCCCCCCCCCCAAAAGGCCCCAC
A
ACAAAAAACCGGGGATCCCCCCCP.AAAAAAAATGGTGAAAATCCCCCCCCACCCCGGGGCACACTTT
back to table Contig8298672 Alignment HK1 laA-149_3p GTCCGTGGTCACCACATCCAGGATATCCAGCGTGAGTACATCGGAGCGGGCAGAGCCCAG

Page 66 sur 136 HK1 laA-47_3p GTCCGTGGTCACCACATCCAGGATATCCAGCGTGAGTACATCGGAGCGGGCAGAGCCCAG
HK1 laA-183_3p GTCCGTGGTCACCACATCCAGGATATCCAGCGTGAGTACATCGGAGCGGGCAGAGCCCAG
HKI laA-223_3p GTCCGTGGTCACCACATCCAGGATATCCAGCGTGAGTACATCGGAGCGGGCAGAGCCCAG

Contig8298672 GTCCGTGGTCACCACATCCAGGATATCCAGCGTGAGTACATCGGAGCGGGCAGAGCCCAG
HK1 laA-149_3p GCGGTTGGTGGCCTCCACCCAGATCTCATAGGGCGTAAAGAGAGCCAGGTCCTTGGGGAT
HK1 1aA-47_3p GCGGTTGGTGGCCTCCACCCAGATCTCATAGGGCGTAAAGAGAGCCAGGTCCTTGGGGAT
HK1 laA-183_3p GCGGTTGGTGGCCTCCACCCAGATCTCATAGGGCGTAAAGAGAGCCAGGTCCTTGGGGAT
HK1 1aA-223_3p GCGGTTGGTGGCCTCCACCCAGATCTCATAGGGCGTAAAGAGAGCCAGGTCCTTGGGGAT

Contig8298672 GCGGTTGGTGGCCTCCACCCAGATCTCATAGGGCGTAAAGAGAGCCAGGTCCTTGGGGAT
HKI laA-149_3p GTGGCAGGAGTGGGGCCCCACTGTGTGGTACTCCTCACATGTGTTGTCCTGGCCATACCA
HK1 laA-47_3p GTGGCAGGAGTGGGGCCCCACTGTGTGGTACTCCTCACATGTGTTGTCCTGGCCATACCA
HK1 laA-183_3p GTGGCAGGAGTGGGGCCCCACTGTGTGGTACTCCTCACATGTGTTGTCCTGGCCATACCA
HK1 laA-223_3p GTGGCAGGAGTGGGGCCCCACTGTGTGGTACTCCTCACATGTGTTGTCCTGGCCATACCA
HKI 1aA-223_5p GTGTTGTCCTGGCCATACCA

Contig8298672 GTGGCAGGAGTGGGGCCCCACTGTGTGGTACTCCTCACATGTGTTGTCCTGGCCATACCA
HK1 laA-149._3p CCTAAGCTTGTACTTGAGGGAGTAGTTGGTGTGGAGGAAGGTCTCCCCNTGGGCCCCNGG
HKI laA-47_3p CCTAAGCTTGTACTTGAGGGAGTAGTTGGTGTGGAGGAAGGTCTCCCCGTGGGCCCCTGG
HK1 laA-183_3p CCTAAGCTTGTACTTGAGGGAGTAGTTGGTGTGGAGGAAGGTCTCCCCGTGGGCCCCTGG
HK1 laA-223_3p CCTAAGCTTGTACTTGAGGGAGTAGTTGGTGTGGAGGAAGGTCTCCCCGTGGGCCCCTGG
HK1 laA-223_5p CCTAAGCTTGTACTTGAGGGAGTAGTTGGTGTGGAGGAAGGTCTCCCCGTGGGCCCCTGG

Cantig8298672 CCTAAGCTTGTACTTGAGGGAGTAGTTGGTGTGGAGGAAGGTCTCCCCGTGGGCCCCTGG
HK1 laA-149_3p CGTCCAGCGGCNGGTCAAGTCCTTCATGTTCTTGGACCAGCNGCTGATGTTGACGGGTTT
HK1 laA-47_3p CGTCCAGCGGCAGGTCAAGTCCTTCATGTTCTTGGACCAGCAACTGATGTTGACGGGTTT
HK1 1aA-183_3p CGTCCAGCGGCCGGTCAAGTCCTTCATGTTCTTGGACCAGCACCTGATGTTGACGGGTTT
HK1 1aA-223_3p CGTCCAGCGGCAGGTCAAGTCCTTCATGTTCTTGGACCAGCAGCTGATGTTGACGGGTTT
HK1 laA-223_5p CGTCCAGCGGCAGGTCAAGTCCTTCATGTTCTTGGACCAGCAGCTGATGTTGACGGGTTT
HK1 laA-47_5p TCCTTCATGTTCTTGGACCAGCAGCTGATGTTGACGGGTTT
HK1 1aA-183_5p CCTTCATGTTCTTGGACCAGCAGCTGATGTTGACGGGTTT

Contig8298672 CGTCCAGCGGCAGGTCAAGTCCTTCATGTTCTTGGACCAGCAGCTGATGTTGACGGGTTT
HK1 laA-149_3p CTCTGGGGGCAGGCCAACATAGAGGCAGGAGCCAGCCAGGATG-CTGCCGTCACGGGCGT
HK1 laA-47_3p CTCTGGGGGCAGGCCAACATAGAAGCAGGAGCCAGCCAGGATGGCTGCCGTCACGGACGT
HKI laA-183_3p CTCTGGGGGCAGGCAAACATAAAGGCAGGAGCCCGCCAGGATG-CTGCCGTCNCGGGCGT
HK1 1aA-223_3p CTCTGGGGGCAGGCCAACATAGAGGCAGGAGCCAGCCAGGATG-CTGCCGTCACGGGCGT
HK1 1aA-223_5p CTTTGGGGGCAGGCCAACATAGAGGCAGGAGCCAGCCAGGATG-CTGCCGTCACGGGCGT
HK1 laA-47_5p CTTTGGGGGCAGGCCAACATAGAGGCAGGAGCCAGCCAGGATG-CTGCCGTCACGGGCGT
HK1 laA-183_5p CTCTGGGGGCAGGCCAACATAGAGGCAGGAGCCAGCCAGGATG-CTGCCGTCACGGGCGT

Contig8298672 CTCTGGGGGCAGGCCAACATAGAGGCAGGAGCCAGCCAGGATG-CTGCCGTCACGGGCGT
HK1 laA-149_3p GGCACACGAAGTTGTCCCCCGACCGGTGCCTGG
HK1 laA-47_3p GGGACAC
HK1 laA-183_3p GGCACACGACGTTGTCCCCCGACCGCTGCCTGGAAGCATTGAAGTTGGCCAGGGCCGGAG
HK1 laA-223_3p GGCACACGAGGTTGTCCCCCGACCGCTGCCTGGACCCATTGAGGTTGGCCAGGGCCAGAG
HK1 laA-223_5p GGCACACGAGGTTGTCCCCCGACCGCTGCCTGGACCCATTGAGGTTGGCCAGGGCCAGAG
HK1 1aA-47_5p GGCACACGAGGTTGTCCCCCGACCGCTGCCTGGACCCATTGAGGTTGGCCAGGGCCAGAG
HK1 laA-183_5p GGCACACGAGGTTGTCCCCCGACCGCTGCCTGGACCCATTGAGGTTGGCCAGGGCCAGAG

Page 67 sur 136 Contig8298672 GGCACACGAGGTTGTCCCCCGACCGCTGCCTGGACCCATTGAGGTTGGCCAGGGCCAGAG
HK1 laA-183_3p CCCNGGTGGGGGCGTTGA
HK1 1aA-223_3p CCAAGGTGGAGGCGTTGAGTACCCGGGAGAGCTCAGGGGGCA
HK1 laA-223_5p CCAAGGTGGAGGCGTTGAGTACACGGGAGAGCTCAGGGGGCAGGCGGCGCCCGTTGAGGG
HK1 laA-47_5p CCAAGGTGGAGGCGTTGAGTACACGGGAGAGCTCAGGGGGCAGGCGGCGCCCGTTGAGGG
HK1 1aA-183_5p CCAAGGTGGAGGCGTTGAGTACACGGGAGAGCTCAGGGGGCAGGCGGCGCCCGTTGAGGG

Contig8298672 CCAAGGTGGAGGCGTTGAGTACACGGGAGAGCTCAGGGGGCAGGCGGCGCCCGTTGAGGG
HK1 1aA-223_5p TCCAGTAGAGGCCCTCGGCGGTGGCTCCTGGTGGGTCTCCGTGCACTGAGCAGGTGGCCA
HK1 1aA-47_5p TCCAGTAGAGGCCCTCGGCGGTGGCTCCTGGTGGGTCTCCGTGCACTGAGCAGGTGGCCA
HK1 laA-183 5p TCCAGTAGAGGCCCTCGGCGGTGGCTCCTGGTGGGTCTCCGTGCACTGAGCAGGTGGCCA
HK1 laA-149_5p CCAGTAGAGGCCCTCGGCGGTGGCTCCTGGTGGGTCTCCGTGCACTGAGCAGGTGGCCA

Contig8298672 TCCAGTAGAGGCCCTCGGCGGTGGCTCCTGGTGGGTCTCCGTGCACTGAGCAGGTGGCCA
HK1 laA-223_5p GCAGGGAGGAGCCGATGAGAAGCGTGGGATCCTGGGGACTGATCACAGCTGTGTGGGCTC
HK1 1aA-47_5p GCAGGGAGGAGCCGATGAGAAGCGTGGGATCCTGGGGACTGATCACAGCTGTGTGGGCTC
HK1 laA-183_5p GCAGGGAGGAGCCGATGAGAAGCGTGGGATCCTGGGGACTGATCACAGCTGTGTGGGCTC
HK1 laA-149,_5p GCAGGGAGGAGCCGATGAGAAGCGTGGGATCCTGGGGACTGATCACAGCTGTGTGGGCTC

Contig8298672 GCAGGGAGGAGCCGATGAGAAGCGTGGGATCCTGGGGACTGATCACAGCTGTGTGGGCTC
HK1 laA-223_5p CTGATCCGGCTCGCGGCGCCCCGAGGACGCAGAGCAGCAGCAGCAGGGGCAGCAACGGCG
HK1 laA-47_5p CTGATCCGGCTCGCGGCGCCCCGAGGACGCAGAGCAGCAGCAGCAGGGGCAGCAACGGCG
HK1 laA-183_5p CTGATCCGGCTCGCGGCGCCCCGAGGACGCAGAGCAGCAGCAGCAGGGGCAGCAACGGCG
HK1 laA-149_5p CTGATCCGGCTCGCGGCGCCCCGAGGACGCAGAGCAGCAGCAGCAGGGGCAGCAACGGCG

Contig8298672 CTGATCCGGCTCGCGGCGCCCCGAGGACGCAGAGCAGCAGCAGCAGGGGCAGCAACGGCG
HK1 laA-223_5p GCGGCCG
HK1 laA-47_5p GCGGCCG
HK1 laA-183_5p GCGGCCG
HK1 laA-149_5p GCGGCCG

Contig8298672 GCGGCCG

Contig8298672 Consensus sequence >Contig8298672 666 nt GTCCGTGGTCACCACATCCAGGATATCCAGCGTGAGTACATCGGAGCGGGCAGAGCCCAGGCGGTTGGTGGCCTCCACC
C
AGATCTCATAGGGCGTAAAGAGAGCCAGGTCCTTGGGGATGTGGCAGGAGTGGGGCCCCACTGTGTGGTACTCCTCACA
T
GTGTTGTCCTGGCCATACCACCTAAGCTTGTACTTGAGGGAGTAGTTGGTGTGGAGGAAGGTCTCCCCGTGGGCCCCTG
G
CGTCCAGCGGCAGGTCAAGTCCTTCATGTTCTTGGACCAGCAGCTGATGTTGACGGGTTTCTCTGGGGGCAGGCCAACA
T
AGAGGCAGGAGCCAGCCAGGATGCTGCCGTCACGGGCGTGGCACACGAGGTTGTCCCCCGACCGCTGCCTGGACCCATT
G
AGGTTGGCCAGGGCCAGAGCCAAGGTGGAGGCGTTGAGTACACGGGAGAGCTCAGGGGGCAGGCGGCGCCCGTTGAGGG
T
CCAGTAGAGGCCCTCGGCGGTGGCTCCTGGTGGGTCTCCGTGCACTGAGCAGGTGGCCAGCAGGGAGGAGCCGATGAGA
A
GCGTGGGATCCTGGGGACTGATCACAGCTGTGTGGGCTCCTGATCCGGCTCGCGGCGCCCCGAGGACGCAGAGCAGCAG
C
AGCAGGGGCAGCAACGGCGGCGGCCG

back to table Contig8298678 Alignment Page 68 sur 136 HK1 laA-247_3p GGGGGGGATTGGGGGGAAAACCCAAAAGGTTACAGGGGGAAATTCCTTTGCCCCCCCCTT

Contig8298678 GGGGGGGATTGGGGGGAAAACCCAAAAGGTTACAGGGGGAAATTCCTTTGCCCCCCCCTT
HK1 laA-247_3p TTATTTTTTTTAAAAGTTTTTGCATTTGGGGG TTCTCCTTCGGAAAAAA

Contig8298678 TTATTTTTTTTAAAAGTTTTTGCATTTGGGGG TTCTCCTTCGGAAAAAA
HK1 laA-247_3p GGGGTCCCAGGGGGGGAAAAATGGGGGGAAGAGGGTGACCCTGAGTCCCAGAATCCTTGG

Contig8298678 GGGGTCCCAGGGGGGGAAAAATGGGGGGAAGAGGGTGACCCTGAGTCCCAGAATCCTTGG
HK1 1aA-247_3p TAAAAAAAAGGTTTGAAAAAP.AAAGTTTTCCGATTTTTAGCCGGGGGGAATTTTCCAAAA

Contig8298678 TAAAAAAAAGGTTTGAAAAAAAAAGTTTTCCGATTTTTAGCCGGGGGGAATTTTCCAAAA
HKl 1aA-247_3p AATTTTCCTGGGGTCCCCCGCAAACCGGGGTGGTTTTGGGCCTGGTTAATTTATTTTTGC

Contig8298678 AATTTTCCTGGGGTCCCCCGCAAACCGGGGTGGTTTTGGGCCTGGTTAATTTATTTTTGC
HK1 laA-247_3p CCTTGGGGGGCAAATGGGAAAAAAAGGTGAAAAATTTTTTAAAAGTTTTTGAAACCAAAC

Contig8298678 CCTTGGGGGGCAAATGGGAAAAAAAGGTGAAAAATTTTTTAAAAGTTTTTGAAACCAAAC
HK1 laA-247_3p CCAATTTGCAAGGCAAATTCGGGGGGGGAGAAAAAAACTGCCCTTTTATTTGACCCCCGG

Contig8298678 CCAATTTGCAAGGCAAATTCGGGGGGGGAGAAAAAAACTGCCCTTTTATTTGACCCCCGG
HK1 laA-247_3p GGTCCCCAAAAGAAAAATTTCCCCAGGGTT

Contig8298678 GGTCCCCAAAAGAAAAATTTCCCCAGGGTT

Contig8298678 Consensus sequence >Contig8298678 471 nt GGGGGGGATTGGGGGGAAAACCCAAAAGGTTACAGGGGGAAATTCCTTTGCCCCCCCCTTTTATTTTTTTTAAAAGTTT
T
TGCATTTGGGGG TTCTCCTTCGGAAAAAAGGGGTCCCAGGGGGGGAAAAATGGGGGGAAGAGGGTGACC
CTGAGTCCCAGAATCCTTGGTAAAAAAAAGGTTTGAAAAAAAAAGTTTTCCGATTTTTAGCCGGGGGGAATTTTCCAAA
A
AATTTTCCTGGGGTCCCCCGCAAACCGGGGTGGTTTTGGGCCTGGTTAATTTATTTTTGCCCTTGGGGGGCAAATGGGA
A
AAAAAGGTGAAAAATTTTTTAAAAGTTTTTGAAACCAAACCCAATTTGCAAGGCAAATTCGGGGGGGGAGAAAAAAACT
G
TATTTGACCCCCGGGGTCCCCAAAAGAAAAATTTCCCCAGGGTTAAAAAAAAAAAAAAAAAAAAA
back to table Contig8298679 Alignment HK1 laA-284_5p TGGCTTTGGGTCCATCCAGGGCTCTCACAGAAATAGTTCCATTTCTCCCAGTTCTTGATG
HK1 laA-52_5p TCCATCCAGGGCTTTCACAGAAAAAGTTCCATTTCTCCCAGTTCTTGATG

Page 69 sur 136 Contig8298679 TGGCTTTGGGTCCATCCAGGGCTCTCACAGAAAAAGTTCCATTTCTCCCAGTTCTTGATG
HK1 1aA-284_5p CTACGATACGGTACCAATATGAGTCATCAATAGTCAAATCTGGGTACTTTACACGTCCAA
HK1 laA-52_5p TTACGATACGGTACCAATATGAGTCATCAATAGTCAAATCTGGGTACTTTACACGTCCAA
HK1 1aA-28_5p ATGAGTCATCAATAGTCAAATCTGGGTACTTTACACGTCCAA

Contig8298679 CTACGATACGGTACCAATATGAGTCATCAATAGTCAAATCTGGGTACTTTACACGTCCAA
HK1 laA-284_5p CTCCAGATCCAACATCCCAGAGGAAGCTGACTTTGCCTTTACGCATTTCTATAGCCAGAA
HK1 laA-52_5p CTCCAGATCCAACATCCCAGAGGAAGCTGACTTTGCCTTTACGCATTTCTATAGCCAGAA
HK1 laA-28_5p CTCCAGATCCAACATCCCAGAGGAAGCTGACTTTGCCTTTACGCATTTCTATAGCCAGAA

Contig8298679 CTCCAGATCCAACATCCCAGAGGAAGCTGACTTTGCCTTTACGCATTTCTATAGCCAGAA
HK1 laA-284_5p AGTCAATAAATTTGGCACTTCCAAGATAAAAGAGGAGGTTATCAGCAACAGCTGTCTTTA
HK1 laA-52_5p AGTCAATAAATTTGGCACTTCCAAGATAAAAGAGGAGGTTATCAGCAACAGCTGTCTTTA
HK1 laA-28_5p AGTCAATAAATTTGGCACTTCCAAGATAAAAGAGGAGGTTATCAGCAACAGCTGTCTTTA

Contig8298679 AGTCAATAAATTTGGCACTTCCAAGATAAAAGAGGAGGTTATCAGCAACAGCTGTCTTTA
HK1 laA-284_5p CGTTGACAACAATATTATTGTAACTTCCTTTCTTGATTTCTGGTTTGTATGTTCGAATGC
HK1 laA-52_5p CGTTGACAACAAAATTATTGTAACTTCCTTTCTTGATTTCTGGTTTGTATGTTCGAATGC
HK1 laA-28__5p CGTTGACAACAATATTATTGTAACTTCCTTTCTTGATTTCTGGTTTGTATGTTCGAATGC

Contig8298679 CGTTGACAACAATATTATTGTAACTTCCTTTCTTGATTTCTGGTTTGTATGTTCGAATGC
HK1 laA-284_5p AGTCACCTCCTGAAGACACAGATACTTTGATAGAATTGGCTTGTTTCCGAGCTTGGTTTA
HK1 laA-52_5p AGTCACCTCCTGAAGACACAGATACTTTGATAGAATTGGCTTGTTTCCGAGCTTGGTTTA
HK1 laA-28_5p AGTCACCTCCTGAAGACACAGATACTTTGATAGAATTGGCTTGTTTCCGAGCTTGGTTTA

Contig8298679 AGTCACCTCCTGAAGACACAGATACTTTGATAGAATTGGCTTGTTTCCGAGCTTGGTTTA
HKl laA-284_5p TCAATTCCTTTATCTCAGAGATGTTTTTCTTTAGGTTATCCTCAAGTTCCTTGATGGGTT
HK1 laA-52_5p TCAATTCCTTTATCTCAGAGATGTTTTTCTTTAGGTTATCCTCAAGTTCCTTGATGGGTT
HK1 laA-28_5p TCAATTCCTTTATCTCAGAGATGTTTTTCTTTAGGTTATCCTCAAGTTCCTTGATGGGTT

Contig8298679 TCAATTCCTTTATCTCAGAGATGTTTTTCTTTAGGTTATCCTCAAGTTCCTTGATGGGTT
HK1 laA-284_5p TGAGTTTATCTATTAGCCGGTCAGCTTCCTGTTCTAAATTTTTGACAGTGGCATCTGCAT
HK1 laA-52_5p TGAGTTTATCTATTAGCCGGTCAGCTTCCTGTTTTAAATTTTTGACAGTGGCATTTGCAT
HK1 laA-28_5p TGAGTTTATCTATTAGCCGGTCAGCTTCCTGTTTTAAATTTTTGACAGTGGCATTTGCAT

Contig8298679 TGAGTTTATCTATTAGCCGGTCAGCTTCCTGTTTTAAATTTTTGACAGTGGCATTTGCAT
HK1 laA-284_5p CGGCAATGATTTTGTTCTTGG
HK1 laA-52_5p CGGCAATGATTTTGTTCTTGG
HK1 laA-28_5p CGGCAATGATTTTGTTTTTGGT

Contig8298679 CGGCAATGATTTTGTTCTTGGT

Contig8298679 Consensus sequence Page 70 sur 136 >Contig8298679 502 nt TGGCTTTGGGTCCATCCAGGGCTCTCACAGAAAAAGTTCCATTTCTCCCAGTTCTTGATGCTACGATACGGTACCAATA
T
GAGTCATCAATAGTCAAATCTGGGTACTTTACACGTCCAACTCCAGATCCAACATCCCAGAGGAAGCTGACTTTGCCTT
T
ACGCATTTCTATAGCCAGAAAGTCAATAAATTTGGCACTTCCAAGATAAAAGAGGAGGTTATCAGCAACAGCTGTCTTT
A
CGTTGACAACAATATTATTGTAACTTCCTTTCTTGATTTCTGGTTTGTATGTTCGAATGCAGTCACCTCCTGAAGACAC
A
GATACTTTGATAGAATTGGCTTGTTTCCGAGCTTGGTTTATCAATTCCTTTATCTCAGAGATGTTTTTCTTTAGGTTAT
C
CTCAAGTTCCTTGATGGGTTTGAGTTTATCTATTAGCCGGTCAGCTTCCTGTTTTAAATTTTTGACAGTGGCATTTGCA
T
CGGCAATGATTTTGTTCTTGGT

back to table Contig8298683 Alignment HK1 1aA-241_5p TAAGGGTCGGAGTTACTACTTTGTTTGCAAAACTTGACTCCACCCCCCAACAAAATACTT

Contig8298683 TAAGGGTCGGAGTTACTACTTTGTTTGCAAAACTTGACTCCACCCCCCAACAAAATACTT
HK1 1aA-241_5p TTGGAAAATTTTTTTTTGAACAGGGGGAAAAA.ACTATCCCCCTCAGGGAAGTGTTTTTCT

Contig8298683 TTGGAAAATTTTTTTTTGAACAGGGGGAAAAAACTATCCCCCTCAGGGAAGTGTTTTTCT
HK1 laA-241_5p TTGCCCACP.AAAAAGAGGAAAAAAAAGGATTCCCCACCGGGACAAAACTGAACCAAAAGG

Contig8298683 TTGCCCACAAAAAAGAGGAAAAAP.AAGGATTCCCCACCGGGACAAAACTGAACCAAAAGG
HK1 1aA-241_5p TCTCCCCCCAGGAAGTCAGGACGGACACTCCCCCCCTATACAACTTCCAGGCAAATTTCT

Contig8298683 TCTCCCCCCAGGAAGTCAGGACGGACACTCCCCCCCTATACAACTTCCAGGCAAATTTCT
HK1 1aA-241_5p ACGCAGAGAAGGAGGACAAACACCGAACACCGGCACACACCCAAGAATCGGGGTGTGACA

Contig8298683 ACGCAGAGAAGGAGGACAAACACCGAACACCGGCACACACCCAAGAATCGGGGTGTGACA
HK1 1aA-241_5p CAAAAGAGAAAAGAACGACACCTAGCAACAGAAGGCGGACGCACCAAACGACACGAAGGC

Contig8298683 CAAAAGAGAAAAGAACGACACCTAGCAACAGAAGGCGGACGCACCAAACGACACGAAGGC
HK1 1aA-241_5p ATAAAAACCGTACAACCACCCCGAAAGCGCGGGNCAAGCACGGAGAGGAACGATAAAAGC

Contig8298683 ATAAAAACCGTACAACCACCCCGAAAGCGCGGGNCAAGCACGGAGAGGAACGATAAAAGC
HK1 1aA-241_5p TGAGGGCCCCCGAAACCGGCGAACAACAAACAAAAAAAGACAAGACAAACG

Contig8298683 TGAGGGCCCCCGAAACCGGCGAACAACAAACAA.AAAAAGACAAGACAAACG
Contig8298683 Consensus sequence >Contig8298683 471 nt TAAGGGTCGGAGTTACTACTTTGTTTGCAAAACTTGACTCCACCCCCCAACAAAATACTTTTGGAAAATTTTTTTTTGA
A

Page 71 sur 136 CAGGGGGAAAAAACTATCCCCCTCAGGGAAGTGTTTTTCTTTGCCCACAAAAAAGAGGAAAAAAAAGGATTCCCCACCG
G
GACAAAACTGAACCAAAAGGTCTCCCCCCAGGAAGTCAGGACGGACACTCCCCCCCTATACAACTTCCAGGCAAATTTC
T
ACGCAGAGAAGGAGGACAAACACCGAACACCGGCACACACCCAAGAATCGGGGTGTGACACAAAAGAGAAAAGAACGAC
A
CCTAGCAACAGAAGGCGGACGCACCAAACGACACGAAGGCATAAAAACCGTACAACCACCCCGAAAGCGCGGGNCAAGC
A
CGGAGAGGAACGATAAAAGCTGAGGGCCCCCGAAACCGGCGAACAACAAACAAAAAAAGACAAGACAAACG

back to table Contig8298685 Alignment HK1 laA-284_3p GAGAGCCCTGGATGGACCCAAAGCCAGCATTGTGCCCAGCACACACCATTCGACGTCTCC
HK1 laA-52_3p ATGGACCCAAAGCCAGCATTGTGCCCAGCACACACCATTCGACGTCTCC

Contig8298685 GAGAGCCCTGGATGGACCCAAAGCCAGCATTGTGCCCAGCACACACCATTCGACGTCTCC
HK1 laA-284_3p TCCAGGGTACACGATTCTAGATGTGGATGCAAATGCAATGCTGTTTGTTGGTGGCCTGAC
HK1 laA-28_3p CTAGATGTGGATGCAAATGCAATGCTGTTTGTTGGTGGCCTGAC
HK1 laA-52_3p TCCAGGGTACACGATTCTAGATGTGGATGCAAATGCAATGCTGTTTGTTGGTGGCCTGAC

Contig8298685 TCCAGGGTACACGATTCTAGATGTGGATGCAAATGCAATGCTGTTTGTTGGTGGCCTGAC
HK1 laA-284_3p TGGGAAATTAAAGAAGGCTGATGCTGTACGTGTGATTACATTCACTGGCTGCATGGGAGA
HK1 laA-28_3p TGGGAAATTAAAGAAGGCTGATGCTGTACGTGTGATTACATTCACTGGCTGCATGGGAGA
HK1 laA-52_3p TGGGAAATTAAAGAAGGCTGATGCTGTACGTGTGATTACATTCACTGGCTGCATGGGAGA

Contig8298685 TGGGAAATTAAAGAAGGCTGATGCTGTACGTGTGATTACATTCACTGGCTGCATGGGAGA
HK1 laA-284_3p AACATACTTTGACAACAAACCTATAGGTTTGTGGAATTTCCGAGAAAAAGAAGGTGACTG
HK1 laA-28_3p AACATACTTTGACAACAAACCTATAGGTTTGTGGAATTTCCGAGAAAAAGAAGGTGACTG
HK1 laA-52_3p AACATACTTTGACAACAAACCTATAGGTTTGTGGAATTTCCGAGAAAAAGAAGGTGACTG

Contig8298685 AACATACTTTGACAACAAACCTATAGGTTTGTGGAATTTCCGAGAAAAAGAAGGTGACTG
HK1 laA-284__3p CAAAGGATGCACTGTCAGTCCTCAGGTGGAAGATAGTGAGGGGACTATTCAATTTGATGG
HK1 laA-28_3p CAAAGGATGCACTGTCAGTCCTCAGGTGGAAGATAGTGAGGGGACTATTCAATTTGATGG
HK1 laA-52_3p CAAAGGATGCACTGTCAGTCCTCAGGTGGAAGATAGTGAGGGGACTATTCAATTTGATGG

Contig8298685 CAAAGGATGCACTGTCAGTCCTCAGGTGGAAGATAGTGAGGGGACTATTCAATTTGATGG
HK1 1aA-284--3p AGAAGGTTATGCATTGGTCAGCCGTCCCATTCGCTGGTACCCCAACATCTCCACTGTCAT
HK1 laA-28_3p AGAAGGTTATGCATTGGTCAGCCGTCCCATTCGCTGGTACCCCAACATCTCCACTGTCAT
HK1 laA-52_3p AGAAGGTTATGCATTGGTCAGCCGTCCCATTCGCTGGTACCCCAACATCTCCACTGTCAT

Contig8298685 AGAAGGTTATGCATTGGTCAGCCGTCCCATTCGCTGGTACCCCAACATCTCCACTGTCAT
HK1 laA-284_3p GTTCAAGTTCAGAACATTTTCTTCGAGTGCTCTTCTGATGTATCTTGCCACACGAGACCT
HK1 laA-28_3p GTTCAAGTTCAGAACATTTTCTTCGAGTGCTCTTCTGATGTATCTTGCCACACGAGACCT
HK1 laA-52_3p GTTCAAGTTCAGAACATTTTCTTCGAGTGCTCTTCTGATGTATCTTGCCACACGAGACCT

Contig8298685 GTTCAAGTTCAGAACATTTTCTTCGAGTGCTCTTCTGATGTATCTTGCCACACGAGACCT
HK1 laA-284_3p GAGAGATTTCATGAGTGTGGAGCTCACTGATGGGCACC
HK1 laA-28_3p GAGAGATTTCATGAGTGTGGAGCTCACTGATGGGCACC
HK1 laA-52_3p GAGAGATTTCATGAGTGTGGAGCTCACTGATGGGCACC

Page 72 sur 136 Contig8298685 GAGAGATTTCATGAGTGTGGAGCTCACTGATGGGCACC

Contig8298685 Consensus sequence >Contig8298685 458 nt GAGAGCCCTGGATGGACCCAAAGCCAGCATTGTGCCCAGCACACACCATTCGACGTCTCCTCCAGGGTACACGATTCTA
G
ATGTGGATGCAAATGCAATGCTGTTTGTTGGTGGCCTGACTGGGAAATTAAAGAAGGCTGATGCTGTACGTGTGATTAC
A
TTCACTGGCTGCATGGGAGAAACATACTTTGACAACAAACCTATAGGTTTGTGGAATTTCCGAGAAAAAGAAGGTGACT
G
CAAAGGATGCACTGTCAGTCCTCAGGTGGAAGATAGTGAGGGGACTATTCAATTTGATGGAGAAGGTTATGCATTGGTC
A
GCCGTCCCATTCGCTGGTACCCCAACATCTCCACTGTCATGTTCAAGTTCAGAACATTTTCTTCGAGTGCTCTTCTGAT
G
TATCTTGCCACACGAGACCTGAGAGATTTCATGAGTGTGGAGCTCACTGATGGGCACC
back to table Contig8298686 Alignment HK1 laA-145_5p Contig8298686 NNNNNNNNNNN
HK1 1aA-145_5p Contig8298686 HK1 laA-145_5p NNNNNAGGGGTGGGGGCGAGCCGCGCGCGCGGCGCGCGGGGGATATATATATCGTCTCTC

Contig8298686 NNNNNAGGGGTGGGGGCGAGCCGCGCGCGCGGCGCGCGGGGGATATATATATCGTCTCTC
HK1 laA-145_5p AGATATGTCTGTGAGGGGGGGGGTGTGTGTGTATCTCGGGGGGGGGGGGGTTTTTCTGTG

Contig8298686 AGATATGTCTGTGAGGGGGGGGGTGTGTGTGTATCTCGGGGGGGGGGGGGTTTTTCTGTG
HK1 laA-145_5p ATAGAGGGTGGCGGGGGGGGGGGCGCACTAGTTGAGAGAGAGCGTGAGACAAGTGTTGGG

Contig8298686 ATAGAGGGTGGCGGGGGGGGGGGCGCACTAGTTGAGAGAGAGCGTGAGACAAGTGTTGGG
HK1 laA-145_5p TGTTTGGGCGTCACTGAGGGGGGGGGTTTCGTTGGTGGTGGGGGGGGAGGGTGTTGTATG

Contig8298686 TGTTTGGGCGTCACTGAGGGGGGGGGTTTCGTTGGTGGTGGGGGGGGAGGGTGTTGTATG
HK1 laA-145_5p TGGGCGCTGCCGAGGGGGGGGGGTGGTGGGTTGTGTGTCGTCTTGTTGGATGTTATTAGT

Contig8298686 TGGGCGCTGCCGAGGGGGGGGGGTGGTGGGTTGTGTGTCGTCTTGTTGGATGTTATTAGT
HK1 laA-145_5p GGGAGGGG

Contig8298686 GGGAGGGG

Page 73 sur 136 Contig8298686 Consensus sequence >Contig8298686 428 nt NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
N
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNAGGGGTGGGGGCGAGCCGCGCGCGCGGCGCGCGG
G
GGATATATATATCGTCTCTCAGATATGTCTGTGAGGGGGGGGGTGTGTGTGTATCTCGGGGGGGGGGGGGTTTTTCTGT
G
ATAGAGGGTGGCGGGGGGGGGGGCGCACTAGTTGAGAGAGAGCGTGAGACAAGTGTTGGGTGTTTGGGCGTCACTGAGG
G
GGGGGGTTTCGTTGGTGGTGGGGGGGGAGGGTGTTGTATGTGGGCGCTGCCGAGGGGGGGGGGTGGTGGGTTGTGTGTC
G
TCTTGTTGGATGTTATTAGTGGGAGGGG

back to table Contig8298688 Alignment HK1 laA-233-5p CCGGTGGCCTTGCGGGGGACTTGGCTGGGCATGGTGGAGAAGGTGGTACCACTGGGAGGT

Contig8298688 CCGGTGGCCTTGCGGGGGACTTGGCTGGGCATGGTGGAGAAGGTGGTACCACTGGGAGGT
HK1 laA-233-5p CACCCACTTTAGAGTGGCTCTTCAGATCCTTGTGAATAGTCTGTGGCCTGGCGGCAACTG

Contig8298688 CACCCACTTTAGAGTGGCTCTTCAGATCCTTGTGAATAGTCTGTGGCCTGGCGGCAACTG
HK1 laA-233-5p AAGTTCCCCCCCCAACCACCATTGATATTGGCTCATCCCTCTTGGCTCTTGGGCCTCCTG

Contig8298688 AAGTTCCCCCCCCAACCACGATTGATATTGGCTCATCCCTCTTGGCTCTTGGGCCTCCTG
HK1 laA-233-5p CCAGGTGGATGGAGTGCGNGTCCAATATTAGTGGAGCCCATGGAGGAGCGAGCCCCCTCT

Contig8298688 CCAGGTGGATGGAGTGCGNGTCCAATATTAGTGGAGCCCATGGAGGAGCGAGCCCCCTCT
HK1 laA-233_5p GTGTCATTGGCATCTGGGGCAGGGCTTCGAGGCGCTGAGGGCCCCCCCTCCATCCTCCCC

Contig8298688 GTGTCATTGGCATCTGGGGCAGGGCTTCGAGGCGCTGAGGGCCCCCCCTCCATCCTCCCC
HK1 laA-233_5p TNCNGGCCGGCTGCTTGCTACACTCCCCGAAAAGCCAGGGCCCTATCTTCTNGGGACTTT

Contig8298688 TNCNGGCCGGCTGCTTGCTACACTCCCCGAAAAGCCAGGGCCCTATCTTCTNGGGACTTT
HK1 laA-233_5p TCCTTTCTTTTTTCAGTTGACAAGGGCGTCTAGGGAGCGCTGGGTGCACACTGAACCCTT

Contig8298688 TCCTTTCTTTTTTCAGTTGACAAGGGCGTCTAGGGAGCGCTGGGTGCACACTGAACCCTT
HK1 laA-233_5p ATACTTGAACCTCTTTCGCAG

Contig8298688 ATACTTGAACCTCTTTCGCAG

Contig8298688 Consensus sequence >Contig8298688 441 nt Page 74 sur 136 CCGGTGGCCTTGCGGGGGACTTGGCTGGGCATGGTGGAGAAGGTGGTACCACTGGGAGGTCACCCACTTTAGAGTGGCT
C
TTCAGATCCTTGTGAATAGTCTGTGGCCTGGCGGCAACTGAAGTTCCCCCCCCAACCACGATTGATATTGGCTCATCCC
T
CTTGGCTCTTGGGCCTCCTGCCAGGTGGATGGAGTGCGNGTCCAATATTAGTGGAGCCCATGGAGGAGCGAGCCCCCTC
T
GTGTCATTGGCATCTGGGGCAGGGCTTCGAGGCGCTGAGGGCCCCCCCTCCATCCTCCCCTNCNGGCCGGCTGCTTGCT
A
CACTCCCCGAAAAGCCAGGGCCCTATCTTCTNGGGACTTTTCCTTTCTTTTTTCAGTTGACAAGGGCGTCTAGGGAGCG
C
TGGGTGCACACTGAACCCTTATACTTGAACCTCTTTCGCAG

back to table Contig8298691 Alignment HK1 laA-2-3p CGTCCGTACCCCGTCTCCCTTCTTCTACGCGCGCCCTCGCTACTCTCGTACGTCTCTGCG

Contig8298691 CGTCCGTACCCCGTCTCCCTTCTTCTACGCGCGCCCTCGCTACTCTCGTACGTCTCTGCG
HK1 laA-2-3p TTTCCCCCCCGTGTCTCTCCTTGTCTCCCCTCTCTGCGCGCGCCCCTCTCCCACGCTCGC

Contig8298691 TTTCCCCCCCGTGTCTCTCCTTGTCTCCCCTCTCTGCGCGCGCCCCTCTCCCACGCTCGC
HK1 laA-2-3p TCGTCCGCGTCGCTCTTCTCTTCGTCGTTCGTTCTCTACCCTCTGGCCTCCTTGCCCGCT

Contig8298691 TCGTCCGCGTCGCTCTTCTCTTCGTCGTTCGTTCTCTACCCTCTGGCCTCCTTGCCCGCT
HK1 laA-2-3p CGTCCCGCTTCCTCGCGCGTCTCCTCCCCTCCTCCTCTCGCGCCTGCCTTGCCCGCCCGC

Contig8298691 CGTCCCGCTTCCTCGCGCGTCTCCTCCCCTCCTCCTCTCGCGCCTGCCTTGCCCGCCCGC
HK1 laA-2-3p TTCTTTCCGCTCCATCTCTTCCCCTCTTCCTTCCCCCTCTTCTCGCCCCCTTCCCCGCCG

Contig8298691 TTCTTTCCGCTCCATCTCTTCCCCTCTTCCTTCCCCCTCTTCTCGCCCCCTTCCCCGCCG
HK1 laA-2-3p TCACGGCCTCCTTCCCCTCTCACCTCTCCCCTCCGCGCCTCTTACGGCTACCGTGCCTGC

Contig8298691 TCACGGCCTCCTTCCCCTCTCACCTCTCCCCTCCGCGCCTCTTACGGCTACCGTGCCTGC
HK1 laA-2-3p GTCGCCCAGTGCTGCGCCTTCCCCTCCCTTCCCGCAGCCCCACCAACCCCTACACCGCTC

Contig8298691 GTCGCCCAGTGCTGCGCCTTCCCCTCCCTTCCCGCAGCCCCACCAACCCCTACACCGCTC
HK1 laA-2_3p TTCTCCCCTGCATAGCCTACGCTGCATCCTACATTCTCCAACTCCCTGCCCTC

Contig8298691 TTCTCCCCTGCATAGCCTACGCTGCATCCTACATTCTCCAACTCCCTGCCCTC
Contig8298691 Consensus sequence >Contig8298691 473 nt CGTCCGTACCCCGTCTCCCTTCTTCTACGCGCGCCCTCGCTACTCTCGTACGTCTCTGCGTTTCCCCCCCGTGTCTCTC
C
TTGTCTCCCCTCTCTGCGCGCGCCCCTCTCCCACGCTCGCTCGTCCGCGTCGCTCTTCTCTTCGTCGTTCGTTCTCTAC
C
CTCTGGCCTCCTTGCCCGCTCGTCCCGCTTCCTCGCGCGTCTCCTCCCCTCCTCCTCTCGCGCCTGCCTTGCCCGCCCG
C
TTCTTTCCGCTCCATCTCTTCCCCTCTTCCTTCCCCCTCTTCTCGCCCCCTTCCCCGCCGTCACGGCCTCCTTCCCCTC
T

Page 75 sur 136 CACCTCTCCCCTCCGCGCCTCTTACGGCTACCGTGCCTGCGTCGCCCAGTGCTGCGCCTTCCCCTCCCTTCCCGCAGCC
C
CACCAACCCCTACACCGCTCTTCTCCCCTGCATAGCCTACGCTGCATCCTACATTCTCCAACTCCCTGCCCTC

back to table Contig8298693 Alignment HK1 laA-134_3p CTCTTTCTTCGGCGCTTCTCCCATTCCCCCTTTCGCGCTGCCCTTTCGGTGGTCTCTCAT

Contig8298693 CTCTTTCTTCGGCGCTTCTCCCATTCCCCCTTTCGCGCTGCCCTTTCGGTGGTCTCTCAT
HK1 laA-134_3p CTCTTTCGGTTTCCTGTTTCCTTCGCCCGTCGGGTGTGGCGTCTCGTTTGTTTGTCTCTC

Contig8298693 CTCTTTCGGTTTCCTGTTTCCTTCGCCCGTCGGGTGTGGCGTCTCGTTTGTTTGTCTCTC
HK1 laA-134_3p TGTTTTTTCCCGTGTCGTGTATTGCTTGTCATCTTTTCATTATTGCTTTTTCCTTTTTTT

Contig8298693 TGTTTTTTCCCGTGTCGTGTATTGCTTGTCATCTTTTCATTATTGCTTTTTCCTTTTTTT
HK1 laA-134_3p GTGTGCTGTTTTTGTTTTTTTTGCGGTTGTTCATTTTTGTTGGTTTTTTTCTTGGTCTTT

Contig8298693 GTGTGCTGTTTTTGTTTTTTTTGCGGTTGTTCATTTTTGTTGGTTTTTTTCTTGGTCTTT
HK1 1aA-134_3p GTCGATGGACCGACTTTTTTTTTTTTTTAGAAAAGAATTTTAGATATTATCCTGATTTTG

Contig8298693 GTCGATGGACCGACTTTTTTTTTTTTTTAGAAAAGAATTTTAGATATTATCCTGATTTTG
HK1 laA-134_3p GGTTTTGGAGTTTGATGATCTGGGGGGGGATTTTTATGCGGAGGGTGTTAAGTTAATGCT

Contig8298693 GGTTTTGGAGTTTGATGATCTGGGGGGGGATTTTTATGCGGAGGGTGTTAAGTTAATGCT
HK1 laA-134_3p ATGGATTTGTTCTCGTTGGAATAAAAAAAGGAACATCTCTTTCAATGACAAAAAGTTTGT

Contig8298693 ATGGATTTGTTCTCGTTGGAATAAAAAAAGGAACATCTCTTTCAATGACAAAAAGTTTGT
HK1 laA-134_3p CTTTAAP.AAAATAGACAAGAAGGTACTTGACTTTGTGTTTTATGTCCAAGTTTTGAGAAA

Contig8298693 CTTTAAP.AAAATAGACAAGAAGGTACTTGACTTTGTGTTTTATGTCCAAGTTTTGAGAAA
HK1 laA-134_3p TAAAAAAAGGA

Contig8298693 TAAAAAAAGGA

Contig8298693 Consensus sequence >Contig8298693 491 nt CTCTTTCTTCGGCGCTTCTCCCATTCCCCCTTTCGCGCTGCCCTTTCGGTGGTCTCTCATCTCTTTCGGTTTCCTGTTT
C
CTTCGCCCGTCGGGTGTGGCGTCTCGTTTGTTTGTCTCTCTGTTTTTTCCCGTGTCGTGTATTGCTTGTCATCTTTTCA
T
TATTGCTTTTTCCTTTTTTTGTGTGCTGTTTTTGTTTTTTTTGCGGTTGTTCATTTTTGTTGGTTTTTTTCTTGGTCTT
T

Page 76 sur 136 GTCGATGGACCGACTTTTTTTTTTTTTTAGAAAAGAATTTTAGATATTATCCTGATTTTGGGTTTTGGAGTTTGATGAT
C
TGGGGGGGGATTTTTATGCGGAGGGTGTTAAGTTAATGCTATGGATTTGTTCTCGTTGGAATAAAAAAAGGAACATCTC
T
TTCAATGACAAAAAGTTTGTCTTTAAAAAAATAGACAAGAAGGTACTTGACTTTGTGTTTTATGTCCAAGTTTTGAGAA
A
TAAAAAAAGGA

back to table Contig8298694 Alignment HK1 laA-233-3p AGGGGTAGCCTCCTCCATTGACCATAGGCTCCATGGAGTAGGACTTGTCCAGACCCATGG

Contig8298694 AGGGGTAGCCTCCTCCATTGACCATAGGCTCCATGGAGTAGGACTTGTCCAGACCCATGG
HK1 laA-233-3p TCAGTGGAGACAGGGCATATGGGTAGCCCCCCTCAATGGTGTTGGTGACTCCGTCCAGAG

Contig8298694 TCAGTGGAGACAGGGCATATGGGTAGCCCCCCTCAATGGTGTTGGTGACTCCGTCCAGAG
HK1 laA-233-3p AAGAGAGTGTGAGCGTGCTGAACGCACAGTCATCTTGGGTTATCAGCAAGTGGTCGTGAG

Contig8298694 AAGAGAGTGTGAGCGTGCTGAACGCACAGTCATCTTGGGTTATCAGCAAGTGGTCGTGAG
HK1 laA-233-3p GAATCTCTCTCAAGGGATGGAATGCAAATCGCAAATACTAAAACAGCATACGGAGGAGCG

Contig8298694 GAATCTCTCTCAAGGGATGGAATGCAAATCGCAAATACTAAAACAGCATACGGAGGAGCG
HK1 laA-233-3p ACAACCCGGTGTGCCAATGGCATCTCAGGCAAGGCTTCGAGGTGGTGAGGGCCGGGCCTC

Contig8298694 ACAACCCGGTGTGCCAATGGCATCTCAGGCAAGGCTTCGAGGTGGTGAGGGCCGGGCCTC
HK1 laA-233-3p CATGCTCACGTACAGGCCGCGTTGCTTGTTGCACTCCAAGGAAAGCCAAGGCACCATCTT

Contig8298694 CATGCTCACGTACAGGCCGCGTTGCTTGTTGCACTCCAAGGAAAGCCAAGGCACCATCTT
HK1 laA-233-3p CTCGGGACTCTGCATGTTTCTTTTCAGTTAACAAAGGAGTGTCAGGAGAGGCGCGTGCAC

Contig8298694 CTCGGGACTCTGCATGTTTCTTTTCAGTTAACAAAGGAGTGTCAGGAGAGGCGCGTGCAC
HK1 laA-233-3p AATGGTCGTTTATACGTTAACATCTTTTTCAG

Contig8298694 AATGGTCGTTTATACGTTAACATCTTTTTCAG

Contig8298694 Consensus sequence >Contig8298694 452 nt AGGGGTAGCCTCCTCCATTGACCATAGGCTCCATGGAGTAGGACTTGTCCAGACCCATGGTCAGTGGAGACAGGGCATA
T
GGGTAGCCCCCCTCAATGGTGTTGGTGACTCCGTCCAGAGAAGAGAGTGTGAGCGTGCTGAACGCACAGTCATCTTGGG
T
TATCAGCAAGTGGTCGTGAGGAATCTCTCTCAAGGGATGGAATGCAAATCGCAAATACTAAAACAGCATACGGAGGAGC
G
ACAACCCGGTGTGCCAATGGCATCTCAGGCAAGGCTTCGAGGTGGTGAGGGCCGGGCCTCCATGCTCACGTACAGGCCG
C
GTTGCTTGTTGCACTCCAAGGAAAGCCAAGGCACCATCTTCTCGGGACTCTGCATGTTTCTTTTCAGTTAACAAAGGAG
T
GTCAGGAGAGGCGCGTGCACAATGGTCGTTTATACGTTAACATCTTTTTCAG

Page 77 sur 136 liback to table Contig8298695 Alignment HK1 laA-225_3p AACCCACAGACGGAGAGAATAGCAGACCAAGAAGGAACTCAAAGAGGCATTGAGAATCAA

Contig8298695 AACCCACAGACGGAGAGAATAGCAGACCAAGAAGGAACTCAAAGAGGCATTGAGAATCAA
HK1 laA-225_3p CACCATTTCACAGACGGGAAGACCAAGGCCAAGTGTCACAGCAGTTATGAGTCAGGGCCA

Contig8298695 CACCATTTCACAGACGGGAAGACCAAGGCCAAGTGTCACAGCAGTTATGAGTCAGGGCCA
HK1 laA-225_3p GAACTAGAAGGTAGGTCTTCTGACTCCCAGCTCAAAGCTCCTATCAGAGGGCACTTTTCC

Contig8298695 GAACTAGAAGGTAGGTCTTCTGACTCCCAGCTCAAAGCTCCTATCAGAGGGCACTTTTCC
HKl laA-225_3p TTGGTAGATATCAGAGAACCACAGGGAGGATCAGGTCACATTCCCAGCTTCCCCTTCACC

Contig8298695 TTGGTAGATATCAGAGAACCACAGGGAGGATCAGGTCACATTCCCAGCTTCCCCTTCACC
HK1 laA-225_3p CTAGCACAGGACCTCACAACTACTTGTTGGGTCACAGATTCAGAGCCAAAATGGCCTCAA

Contig8298695 CTAGCACAGGACCTCACAACTACTTGTTGGGTCACAGATTCAGAGCCAAAATGGCCTCAA
HK1 laA-225_3p AGATCTAACTCAGACTGGATAACAGATGGTATTAAGGCATTATTAATTATGTTAGGTGCA

Contig8298695 AGATCTAACTCAGACTGGATAACAGATGGTATTAAGGCATTATTAATTATGTTAGGTGCA
HK1 laA-225_3p GTAATGGCATTTTGATTATGTTAAAAAGAAGAGAGTAAGTCTGTATCTGTCAGAGAAACA

Contig8298695 GTAATGGCATTTTGATTATGTTAAAAAGAAGAGAGTAAGTCTGTATCTGTCAGAGAAACA
HK1 laA-225_3p TACAGAAATATTTATGAATGAAATGATCCAAT

Contig8298695 TACAGAAATATTTATGAATGAAATGATCCAAT

Contig8298695 Consensus sequence >Contig8298695 452 nt AACCCACAGACGGAGAGAATAGCAGACCAAGAAGGAACTCAAAGAGGCATTGAGAATCAACACCATTTCACAGACGGGA
A
GACCAAGGCCAAGTGTCACAGCAGTTATGAGTCAGGGCCAGAACTAGAAGGTAGGTCTTCTGACTCCCAGCTCAAAGCT
C
CTATCAGAGGGCACTTTTCCTTGGTAGATATCAGAGAACCACAGGGAGGATCAGGTCACATTCCCAGCTTCCCCTTCAC
C
CTAGCACAGGACCTCACAACTACTTGTTGGGTCACAGATTCAGAGCCAAAATGGCCTCAAAGATCTAACTCAGACTGGA
T
AACAGATGGTATTAAGGCATTATTAATTATGTTAGGTGCAGTAATGGCATTTTGATTATGTTAAAAAGAAGAGAGTAAG
T
CTGTATCTGTCAGAGAAACATACAGAAATATTTATGAATGAAATGATCCAAT
back to table Contig8298697 Alignment Page 78 sur 136 HK1 laA-69_5p TACTCCTTCCTGCTCCAGCCCGGCCCGACCCGACCGCACCCGGCGCCTGCCCTCGCTCGG

Contig8298697 TACTCCTTCCTGCTCCAGCCCGGCCCGACCCGACCGCACCCGGCGCCTGCCCTCGCTCGG
HK1 1aA-69_5p CGTCCCCGGCCAGCCATGGGCCCTTGGAGCCGCAGCCTCTCGGCGCTGCTGCTGCTGCTG

Contig8298697 CGTCCCCGGCCAGCCATGGGCCCTTGGAGCCGCAGCCTCTCGGCGCTGCTGCTGCTGCTG
HK1 laA-69_5p CAGGTCTCCTCTTGGCTGTGCCTCGCTCCTNACCCTGNNNNNNNNANNNNNNGGNNNNNN

Contig8298697 CAGGTCTCCTCTTGGCTGTGCCTCGCTCCTNACCCTGNNNNNNNNANNNNNNGGNNNNNN
HK1 laA-69_5p GNNNNNNNNGGGNNGNNGGGNNNNNGGGNGGGGGGGGGGGNGNGGGNGGGGNNNNNNNGG

Contig8298697 GNNNNNNNNGGGNNGNNGGGNNNNNGGGNGGGGGGGGGGGNGNGGGNGGGGNNNNNNNGG
HK1 laA-69_5p GGGANNNGNGNNGGGGGGAGGNGNGNGNGAGAGANGGAAAGGGGGGGGGGGGGGGAGGGG

Contig8298697 GGGANNNGNGNNGGGGGGAGGNGNGNGNGAGAGANGGAAAGGGGGGGGGGGGGGGAGGGG
HK1 laA-69_5p NAGNAGGGAAGAAGAAAGGGNGAAGGAGGAGGANANAAGAAAGAAGAGGANAGGGGAGGA

Contig8298697 NAGNAGGGAAGAAGAAAGGGNGAAGGAGGAGGANANAAGAAAGAAGAGGANAGGGGAGGA
HK1 laA-69_5p AAGGAGAAGAAGGGGGAGGAAGGGAAGAAGGAGGAGAAGGACAAGAAGAGAGAAAGAGAG

Contig8298697 AAGGAGAAGAAGGGGGAGGAAGGGAAGAAGGAGGAGAAGGACAAGAAGAGAGAAAGAGAG
HK1 laA-69_5p GGAGAAGCAGAAGAAGAAAGAAGAGACAA

Contig8298697 GGAGAAGCAGAAGAAGAAAGAAGAGACAA

Contig8298697 Consensus sequence >Contig8298697 449 nt TACTCCTTCCTGCTCCAGCCCGGCCCGACCCGACCGCACCCGGCGCCTGCCCTCGCTCGGCGTCCCCGGCCAGCCATGG
G
CCCTTGGAGCCGCAGCCTCTCGGCGCTGCTGCTGCTGCTGCAGGTCTCCTCTTGGCTGTGCCTCGCTCCTNACCCTGNN
N
NNNNNANNNNNNGGNNNNNNGNNNNNNNNGGGNNGNNGGGNNNNNGGGNGGGGGGGGGGGNGNGGGNGGGGNNNNNNNG
G
GGGANNNGNGNNGGGGGGAGGNGNGNGNGAGAGANGGAAAGGGGGGGGGGGGGGGAGGGGNAGNAGGGAAGAAGAAAGG
G
NGAAGGAGGAGGANANAAGAAAGAAGAGGANAGGGGAGGAAAGGAGAAGAAGGGGGAGGAAGGGAAGAAGGAGGAGAAG
G
ACAAGAAGAGAGAAAGAGAGGGAGAAGCAGAAGAAGAAAGAAGAGACAA

back to table Contig8298698 Alignment HK1 laA-146_5p CGAGCCCCGACGAGTCCCCGCGCCTCATCCGCCCGCGTCCGGTCCGCGTTCCTCCGCCCC

Contig8298698 CGAGCCCCGACGAGTCCCCGCGCCTCATCCGCCCGCGTCCGGTCCGCGTTCCTCCGCCCC

Page 79 sur 136 HK1 laA-146_5p ACCATGGCTCGGGGCCCCGGCCTCGCGCCGCCACCGCTGCGGCTGCCGCTGCTGCTGCTG

Contig8298698 ACCATGGCTCGGGGCCCCGGCCTCGCGCCGCCACCGCTGCGGCTGCCGCTGCTGCTGCTG
HK1 laA-146_5p GTGCTGGCGGCGGTGACCGGCCACACGGCCGCGCAGGACAACTGCACGTGTCCCACCAAC

Contig8298698 GTGCTGGCGGCGGTGACCGGCCACACGGCCGCGCAGGACAACTGCACGTGTCCCACCAAC
HK1 laA-146_5p AAGATGACCGTGTGCAGCCCCGACGGCCCCGGCGGCCGCTGCCAGTGCCGCGCGCTGGGC

Contig8298698 AAGATGACCGTGTGCAGCCCCGACGGCCCCGGCGGCCGCTGCCAGTGCCGCGCGCTGGGC
HK1 laA-146_5p TCGGGCATGGCGGTCGACTGCTCCACGCTGACCTCCAAGTGTCTGCTGCTCAAGGCGCGC

Contig8298698 TCGGGCATGGCGGTCGACTGCTCCACGCTGACCTCCAAGTGTCTGCTGCTCAAGGCGCGC
HK1 laA-146_5p ATGAGCGCCCCCAAGAACGCCCGCACGCTGGTGCGGCCGAGTGAGCACGCGCTCGTGGAC

Contig8298698 ATGAGCGCCCCCAAGAACGCCCGCACGCTGGTGCGGCCGAGTGAGCACGCGCTCGTGGAC
HK1 laA-146_5p AACGATGGCCTCTACGACCCCGACTGCGACCCCGAGGGCCGCTT

Contig8298698 AACGATGGCCTCTACGACCCCGACTGCGACCCCGAGGGCCGCTT
Contig8298698 Consensus sequence >Contig8298698 404 nt CGAGCCCCGACGAGTCCCCGCGCCTCATCCGCCCGCGTCCGGTCCGCGTTCCTCCGCCCCACCATGGCTCGGGGCCCCG
G
CCTCGCGCCGCCACCGCTGCGGCTGCCGCTGCTGCTGCTGGTGCTGGCGGCGGTGACCGGCCACACGGCCGCGCAGGAC
A
ACTGCACGTGTCCCACCAACAAGATGACCGTGTGCAGCCCCGACGGCCCCGGCGGCCGCTGCCAGTGCCGCGCGCTGGG
C
TCGGGCATGGCGGTCGACTGCTCCACGCTGACCTCCAAGTGTCTGCTGCTCAAGGCGCGCATGAGCGCCCCCAAGAACG
C
CCGCACGCTGGTGCGGCCGAGTGAGCACGCGCTCGTGGACAACGATGGCCTCTACGACCCCGACTGCGACCCCGAGGGC
C
GCTT

back to table Contig8298700 Alignment HK1 laA-191_3p CCCCCCCTTTTCCCGCCCCCTTCTTTCTCCTTCTCCTCTCTTCTCCCCATCCCGTCTCGT

Contig8298700 CCCCCCCTTTTCCCGCCCCCTTCTTTCTCCTTCTCCTCTCTTCTCCCCATCCCGTCTCGT
HK1 1aA-191_3p TCTCTTTGCTATCTTTCTCATTCTCCTCCTTTCTTTTCTCTTGCCACACCCCTCCCTCTC

Contig8298700 TCTCTTTGCTATCTTTCTCATTCTCCTCCTTTCTTTTCTCTTGCCACACCCCTCCCTCTC
HK1 1aA-191_3p CTCTCCCCCTACTCTTTCCCCTCTCCCTCTCCTCCGCTTCCTCCTCTCTTTCCCTTCCCG

Page 80 sur 136 Contig8298700 CTCTCCCCCTACTCTTTCCCCTCTCCCTCTCCTCCGCTTCCTCCTCTCTTTCCCTTCCCG
HK1 laA-191_3p CGCCAGCTTCTGCTCTCTTTGTTTGTGTTTTTTATTTTGCCCCCCCGCTCCTCTCCCGTC

Contig8298700 CGCCAGCTTCTGCTCTCTTTGTTTGTGTTTTTTATTTTGCCCCCCCGCTCCTCTCCCGTC
HK1 laA-191_3p TATCTCTTCCTCTTTTCTTCTTTTTTTCCTCCCTTCCGCCCCTTTATTTCTCTTTTCATC

Contig8298700 TATCTCTTCCTCTTTTCTTCTTTTTTTCCTCCCTTCCGCCCCTTTATTTCTCTTTTCATC
HK1 laA-191_3p TCCTTCGCCTCTCTCTCCCCCGCTGGGGGGCTAACACCATCCCCCCCACCATCCTTCGTC

Contig8298700 TCCTTCGCCTCTCTCTCCCCCGCTGGGGGGCTAACACCATCCCCCCCACCATCCTTCGTC
HK1 laA-191_3p CCGCCTTTTTTCCCCCCTCC TTTTTTTCCGGTCCGTAAATCATTTTCGG

ContigB298700 CCGCCTTTTTTCCCCCCTCC TTTTTTTCCGGTCCGTAAATCATTTTCGG
HK1 1aA-191_3p TC CCCTACTCACTTTTTATTTTTTCTCACACACACAGGCACACACT

Contig8298700 TC CCCTACTCACTTTTTATTTTTTCTCACACACACAGGCACACACT
HK1 laA-191_3p TGGGAACCATA

Contig8298700 TGGGAACCATA

Contig8298700 Consensus sequence >ContigB298700 491 nt CCCCCCCTTTTCCCGCCCCCTTCTTTCTCCTTCTCCTCTCTTCTCCCCATCCCGTCTCGTTCTCTTTGCTATCTTTCTC
A
TTCTCCTCCTTTCTTTTCTCTTGCCACACCCCTCCCTCTCCTCTCCCCCTACTCTTTCCCCTCTCCCTCTCCTCCGCTT
C
CTCCTCTCTTTCCCTTCCCGCGCCAGCTTCTGCTCTCTTTGTTTGTGTTTTTTATTTTGCCCCCCCGCTCCTCTCCCGT
C
TATCTCTTCCTCTTTTCTTCTTTTTTTCCTCCCTTCCGCCCCTTTATTTCTCTTTTCATCTCCTTCGCCTCTCTCTCCC
C
CGCTGGGGGGCTAACACCATCCCCCCCACCATCCTTCGTCCCGCCTTTTTTCCCCCCTCC TTTTTTTCC
GGTCCGTAAATCATTTTCGGTC CCCTACTCACTTTTTATTTTTTCTCACACACACAGGCACACACT
TGGGAACCATA

back to table Contig8298702 Alignment HK1 1aA-246_3p ACTCCTCCCGCCGGGGCCCACGCGTGGGGGGGGGGGGTTGTGGGCGCCTCCCTTCCTCCC

Contig8298702 ACTCCTCCCGCCGGGGCCCACGCGTGGGGGGGGGGGGTTGTGGGCGCCTCCCTTCCTCCC
HK1 laA-246_3p CCTCCCTTTTGTGTTATAAAAAGCGTTTGGGAAAACACACCTTCTCTCTCCTTGGTTTGT

Contig8298702 CCTCCCTTTTGTGTTATAAAAAGCGTTTGGGAAAACACACCTTCTCTCTCCTTGGTTTGT
HK1 laA-246_3p GGGGGGGGGGGGTTCCACACAAAAAAATTTTTTTTTTGGGCCCCCCCCCCCCACACCGGG

Page 81 sur 136 Contig8298702 GGGGGGGGGGGGTTCCACACAAAAAAATTTTTTTTTTGGGCCCCCCCCCCCCACACCGGG
HK1 laA-246_3p TTTTTTTTGGGGCCCGGGTTATTTTTTTTCCCCCCCGGGGGGGGGCCCGGTGTAAAAAAA

Contig8298702 TTTTTTTTGGGGCCCGGGTTATTTTTTTTCCCCCCCGGGGGGGGGCCCGGTGTAAAAAAA
HK1 1aA-246_3p AAGGGGAAGTTTTTTTAGAAGTTTTTTAAACCCACCACCCGGGGAGCAGGAANNATTTTC

Contig8298702 AAGGGGAAGTTTTTTTAGAAGTTTTTTAAACCCACCACCCGGGGAGCAGGAANNATTTTC
HK1 1aA-246_3p GGGGGGGGGAAAAAAAAAAGGNNGAGNGNCTNCTTATAATTGGACCCCCCGGGGGTCCCC

Contig8298702 GGGGGGGGGAAAAAAAAAAGGNNGAGNGNCTNCTTATAATTGGACCCCCCGGGGGTCCCC
HK1 1aA-246_3p GGGTGGATGGGTTCCCCAGGGGT

Contig8298702 GGGTGGATGGGTTCCCCAGGGGT

Contig8298702 Consensus sequence >Contig8298702 404 nt ACTCCTCCCGCCGGGGCCCACGCGTGGGGGGGGGGGGTTGTGGGCGCCTCCCTTCCTCCCCCTCCCTTTTGTGTTATAA
A
AAGCGTTTGGGAAAACACACCTTCTCTCTCCTTGGTTTGTGGGGGGGGGGGGTTCCACACAAAAAAATTTTTTTTTTGG
G
CCCCCCCCCCCCACACCGGGTTTTTTTTGGGGCCCGGGTTATTTTTTTTCCCCCCCGGGGGGGGGCCCGGTGTAAP.AA
AA
AAGGGGAAGTTTTTTTAGAAGTTTTTTAAACCCACCACCCGGGGAGCAGGAANNATTTTCGGGGGGGGGAAAAAAAAAA
G
GNNGAGNGNCTNCTTATAATTGGACCCCCCGGGGGTCCCCGGGTGGATGGGTTCCCCAGGGGTAAAAAAAAAAAAAAAA
A
AAAA

back to table Contig8298704 Alignment HK1 1aA-257_3p TAGGGGTGTTTAGCGGGGTGATATTTGGGGGCACCATCACTCTGTCCTGTGGGGGGTATC

Contig8298704 TAGGGGTGTTTAGCGGGGTGATATTTGGGGGCACCATCACTCTGTCCTGTGGGGGGTATC
HK1 laA-257_3p GCATGGGGGCGCCGCGCATCTATGTGGGTTCTGTTTCTCGGCGGGTGGCCATGATCCGCG

Contig8298704 GCATGGGGGCGCCGCGCATCTATGTGGGTTCTGTTTCTCGGCGGGTGGCCATGATCCGCG
HK1 laA-257_3p GAGTTTGGGGGGTGTGGAGGACCTCGTGCTATCTGCGTTGCGACGGCGGGTTCTCGTCTG

Contig8298704 GAGTTTGGGGGGTGTGGAGGACCTCGTGCTATCTGCGTTGCGACGGCGGGTTCTCGTCTG
HK1 laA-257__3p CGGGTCGCGCGGTGTTACTCGCGTTCGTGCGTTCCGCGGCGTCGCATCTTCCGGTAGGGT

Contig8298704 CGGGTCGCGCGGTGTTACTCGCGTTCGTGCGTTCCGCGGCGTCGCATCTTCCGGTAGGGT

Page 82 sur 136 HK1 1aA-257_3p CGGTGGTGCTGTATGGTGCGGGGTATGGGTGCGTCGCACTTGTTAGCCTCGCCTTTTTAC

Contig8298704 CGGTGGTGCTGTATGGTGCGGGGTATGGGTGCGTCGCACTTGTTAGCCTCGCCTTTTTAC
HK1 laA-257_3p TTTGGAGGCGCAAGGTGGCAACTTCATTTGTGTCATGTTGGCATGTAGATGGGTTTGGTT

Contig8298704 TTTGGAGGCGCAAGGTGGCAACTTCATTTGTGTCATGTTGGCATGTAGATGGGTTTGGTT
HK1 laA-257_3p AAGGTGGATGCTTAGTGTGATTTATGTGGTTGCAGGAAATTGGCGCTTCGTTCGCTCCAC

Contig8298704 AAGGTGGATGCTTAGTGTGATTTATGTGGTTGCAGGAAATTGGCGCTTCGTTCGCTCCAC
HK1 1aA-257_3p TCGGGGGGATATCGGCCTTGGGAGAATCCAGGTTCTGCCTATCCGATTGCTCATCCGGTG

Contig8298704 TCGGGGGGATATCGGCCTTGGGAGAATCCAGGTTCTGCCTATCCGATTGCTCATCCGGTG
HK1 laA-257_3p TGTGCTATGCAATTCCTCCCCAAATATAGATCTTATTTCTGCTCATTTCCCCCACTTATT

Contig8298704 TGTGCTATGCAATTCCTCCCCAAATATAGATCTTATTTCTGCTCATTTCCCCCACTTATT
HK1 laA-257_3p AAAATCAC

Contig8298704 AAAATCAC

Contig8298704 Consensus sequence >Contig8298704 548 nt TAGGGGTGTTTAGCGGGGTGATATTTGGGGGCACCATCACTCTGTCCTGTGGGGGGTATCGCATGGGGGCGCCGCGCAT
C
TATGTGGGTTCTGTTTCTCGGCGGGTGGCCATGATCCGCGGAGTTTGGGGGGTGTGGAGGACCTCGTGCTATCTGCGTT
G
CGACGGCGGGTTCTCGTCTGCGGGTCGCGCGGTGTTACTCGCGTTCGTGCGTTCCGCGGCGTCGCATCTTCCGGTAGGG
T
CGGTGGTGCTGTATGGTGCGGGGTATGGGTGCGTCGCACTTGTTAGCCTCGCCTTTTTACTTTGGAGGCGCAAGGTGGC
A
ACTTCATTTGTGTCATGTTGGCATGTAGATGGGTTTGGTTAAGGTGGATGCTTAGTGTGATTTATGTGGTTGCAGGAAA
T
TGGCGCTTCGTTCGCTCCACTCGGGGGGATATCGGCCTTGGGAGAATCCAGGTTCTGCCTATCCGATTGCTCATCCGGT
G
TGTGCTATGCAATTCCTCCCCAAATATAGATCTTATTTCTGCTCATTTCCCCCACTTATTAAAATCAC

back to table Contig8298706 Alignment HK1 laA-258_3p CCCCCCCCTACTTTCGCGTCCTAATACCCCTCCCCCTATTTACTCCCGGCTCCTCTCCTT

Contig8298706 CCCCCCCCTACTTTCGCGTCCTAATACCCCTCCCCCTATTTACTCCCGGCTCCTCTCCTT
HK1 1aA-258_3p CGCCACCTGGGCATCGCCCCTGGTCTTTTCTCGCGCTCCCTTCTCCGAACCTGCCACCTT

Contig8298706 CGCCACCTGGGCATCGCCCCTGGTCTTTTCTCGCGCTCCCTTCTCCGAACCTGCCACCTT
HK1 laA-258_3p ACCCTCCCAATTAATTTCTATTTCCCCCATTCTCCTTCTCCAGGGCCCCGCGTTGCTCTC

Page 83 sur 136 Contig8298706 ACCCTCCCAATTAATTTCTATTTCCCCCATTCTCCTTCTCCAGGGCCCCGCGTTGCTCTC
HK1 laA-258_3p CCCGTCCTCCCCTCGCTCGCGTTAACAACTTTTGCGGTGGGCACAACACGCTTCCCCACC

Contig8298706 CCCGTCCTCCCCTCGCTCGCGTTAACAACTTTTGCGGTGGGCACAACACGCTTCCCCACC
HK1 laA-258_3p ATCCCTCCTGGCCTCCCCCCTTAAAAAAAATATTTTTTTGTTCTCTCCCACCACCCAATA

Contig8298706 ATCCCTCCTGGCCTCCCCCCTTAAAAAAAATATTTTTTTGTTCTCTCCCACCACCCAATA
HK1 laA-258_3p TTTTCCCGCCCGGGGCCGTTCTTCTTCCCCTTGGGGGGCCAAATGAAAAAAAAGGCCAAA

Contig8298706 TTTTCCCGCCCGGGGCCGTTCTTCTTCCCCTTGGGGGGCCAAATGAAAAAAAAGGCCAAA
HK1 laA-258_3p ATTTTTTTAATGTTTTTGGAACCCAATCCCAAAAATCAGGGTATATTTGGGGGGGAAGAA

Contig8298706 ATTTTTTTAATGTTTTTGGAACCCAATCCCAAAAATCAGGGTATATTTGGGGGGGAAGAA
HK1 laA-258_3p AAAACCCGCCCCTAAATTTGACCCCTTGGGTCCCAAAAAAAAAAGATCCCCCGGGGTTAA

Contig8298706 AAAACCCGCCCCTAAATTTGACCCCTTGGGTCCCAAAAAAAAAAGATCCCCCGGGGTTAA
HK1 laA-258_3p AAAAAAAAAAAAAAAAAAA

Contig8298706 AAAAAAAAAAAAAAAAAAA

Contig8298706 Consensus sequence >Contig8298706 499 nt CCCCCCCCTACTTTCGCGTCCTAATACCCCTCCCCCTATTTACTCCCGGCTCCTCTCCTTCGCCACCTGGGCATCGCCC
C
TGGTCTTTTCTCGCGCTCCCTTCTCCGAACCTGCCACCTTACCCTCCCAATTAATTTCTATTTCCCCCATTCTCCTTCT
C
CAGGGCCCCGCGTTGCTCTCCCCGTCCTCCCCTCGCTCGCGTTAACAACTTTTGCGGTGGGCACAACACGCTTCCCCAC
C
ATCCCTCCTGGCCTCCCCCCTTAAAAAAAATATTTTTTTGTTCTCTCCCACCACCCAATATTTTCCCGCCCGGGGCCGT
T
CTTCTTCCCCTTGGGGGGCCAAATGAAAAAAAAGGCCAAAATTTTTTTAATGTTTTTGGAACCCAATCCCAAAAATCAG
G
GTATATTTGGGGGGGAAGAAAAAACCCGCCCCTAAATTTGACCCCTTGGGTCCCAAAAAAAAAAGATCCCCCGGGGTTA
A
AAAAAAAAAAAAAAAAAAA

back to table Contig8298708 Alignment HK1 1aA-113_5p CCGCCGTCCCTGGTCGTACTGCTGCTGGCGGCAGGATGGATCTGAACTCCCTGCTGATCC

Contig8298708 CCGCCGTCCCTGGTCGTACTGCTGCTGGCGGCAGGATGGATCTGAACTCCCTGCTGATCC
HK1 laA-113_5p TGCTGGTATGCGGCTCGATTACTTGGTAGCGCAGGGATAGATTAGGCCAATCACGGTTAC

Contig8298708 TGCTGGTATGCGGCTCGATTACTTGGTAGCGCAGGGATAGATTAGGCCAATCACGGTTAC
HK1 laA-113_5p ACCTCGGTGCTGCCCTTCCACGGCTACTTAACTCGGGAAGAAAACAAAGGCGGCACGGCC

Page 84 sur 136 Contig8298708 ACCTCGGTGCTGCCCTTCCACGGCTACTTAACTCGGGAAGAAAACAAAGGCGGCACGGCC
HK1 laA-113_5p TGGTGCGCACGGTCTTGAAGAATACGTTTTCACACAGCCATGATATGAAGAGCACAGACG

Contig8298708 TGGTGCGCACGGTCTTGAAGAATACGTTTTCACACAGCCATGATATGAAGAGCACAGACG
HK1 laA-113_5p ACCCTAACTCTGGCTGTACCTTGATCAACTCAAGCAGCTGGTGACTATGGGCCCCGACAG

Contig8298708 ACCCTAACTCTGGCTGTACCTTGATCAACTCAAGCAGCTGGTGACTATGGGCCCCGACAG
HK1 laA-113_5p CTCCCGACACACTATTCTAAGTCTCGTGAACCGGGCCAATGTGCACATCAGGAAAATGGA

Contig8298708 CTCCCGACACACTATTCTAAGTCTCGTGAACCGGGCCAATGTGCACATCAGGAAAATGGA
HK1 laA-113_5p GGATCAAGAACGCCGGGCACTGAGCATTAAGGAGCAGCTGCGTGATGAGCATCGTTTCC

Contig8298708 GGATCAAGAACGCCGGGCACTGAGCATTAAGGAGCAGCTGCGTGATGAGCATCGTTTCC
Contig8298708 Consensus sequence >Contig8298708 419 nt CCGCCGTCCCTGGTCGTACTGCTGCTGGCGGCAGGATGGATCTGAACTCCCTGCTGATCCTGCTGGTATGCGGCTCGAT
T
ACTTGGTAGCGCAGGGATAGATTAGGCCAATCACGGTTACACCTCGGTGCTGCCCTTCCACGGCTACTTAACTCGGGAA
G
AAAACAAAGGCGGCACGGCCTGGTGCGCACGGTCTTGAAGAATACGTTTTCACACAGCCATGATATGAAGAGCACAGAC
G
ACCCTAACTCTGGCTGTACCTTGATCAACTCAAGCAGCTGGTGACTATGGGCCCCGACAGCTCCCGACACACTATTCTA
A
GTCTCGTGAACCGGGCCAATGTGCACATCAGGAAAATGGAGGATCAAGAACGCCGGGCACTGAGCATTAAGGAGCAGCT
G
CGTGATGAGCATCGTTTCC

back to table Contig8298710 Alignment HK1 laA-270_3p ATATNNTCGTTTTGGCGTCCCATTTTATCCCTTTTTTTTCACATATCCCCCTCTTTCCAT

Contig8298710 ATATNNTCGTTTTGGCGTCCCATTTTATCCCTTTTTTTTCACATATCCCCCTCTTTCCAT
HK1 laA-270_3p CCTGTCGCCGCAGTTCCCTCTCCCTCTCTTCTCTATTCCTCCCTCCCTCTCCCTTTTTGC

Contig8298710 CCTGTCGCCGCAGTTCCCTCTCCCTCTCTTCTCTATTCCTCCCTCCCTCTCCCTTTTTGC
HK1 laA-270_3p TTTTCCTTTCTCCCCTGCTCCCGTCATCCCTCCCCCCCCCCCCCTTCGCCCCTTCTCTTT

Contig8298710 TTTTCCTTTCTCCCCTGCTCCCGTCATCCCTCCCCCCCCCCCCCTTCGCCCCTTCTCTTT
HK1 laA-270_3p TCGCNCCTCTCCTCCCCCCACCCCCCGCGTCCAGCCGCCCGCTCCCTCCCCCTCCCGTAT

Contig8298710 TCGCNCCTCTCCTCCCCCCACCCCCCGCGTCCAGCCGCCCGCTCCCTCCCCCTCCCGTAT

Claims (31)

1. Method of screening for anti-coronavirus molecules comprising the steps of :

a) providing a collection of antiviral candidate molecules;

b) contacting a candidate antiviral molecule with at least one coronavirus protein or a fragment thereof to obtain a mixture;

c) adding to said mixture, a determined cellular interacting protein or fragment thereof;

d) determining whether said candidate antiviral protein reduces or inhibits the binding interaction between the coronavirus protein and said cellular interacting protein or fragment thereof; and e) identifying said candidate antiviral molecule.

2. The method of claim 1, wherein the binding interaction between the coronavirus protein and said cellular interacting protein is important in the life cycle of a coronavirus.

3. The method of claim 1 or 2, wherein said coronavirus is responsible of Severe Acute Respiratory Syndrome Coronavirus (SARS-Co-V).

4. The method of any one of claims 1 to 3, wherein said coronavirus protein is the SARS-CoV Spike protein.

5. The method of any one of claims 1 to 3, wherein said fragment of the coronavirus is the Spike cytosolic tail.

6. The method of claim 5, wherein the Spike cytosolic tail has the amino acid sequence CCMTSCCSCLKGACSCGSCCKFDEDDSEPVLKGVKLHYT.

7. The method of any one of claims 1 to 6, wherein said collection of antiviral candidate molecules is a library of molecules.

8. The method of any one of claims 1 to 7, wherein said cellular interacting protein or a fragment thereof is obtained from a cell lysate.

9. The method of any one of claims 1 to 7, wherein said cellular interacting protein or a fragment thereof is a purified cellular interacting protein or a fragment thereof.

10. The method of any one of claims 1 to 9, wherein said determined cytoskeleton-linked cellular interacting protein comprises a FERM domain.

11. The method of claim 10, wherein the cytoskeleton- linked cellular interacting protein is selected from the group consisting of ezrin, radixine, protein 4.1 and moesin.

12. The method of any one of claims 1 to 9, wherein the cellular interacting protein is selected from the group consisting of E-cadherine and alpha 5 integrin.

13. The method of claim 11, wherein the ezrin has the amino acid sequence NVRVTTMDAELEFAIQPNTTGKQLFDQWKTIGLREVWYFGLHYVDNKGFPTWLKL
DKKVSAQEVRKENPLQFKFRAKFYPEDVAEEL.

14 The method of claims 11 and 13, wherein the radexine, the protein 4.1 and the moesin have a strong homology with the ezrin amino acid sequence.

15. The method of claim 12, wherein the E-cadherin has the amino acid sequence SRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFED
CTGRQRTAYFSLD.

16. The method of claim 12, wherein the alpha5 integrin has the amino acid sequence PLLPLLLLLLPPPPRVGGFNLDAEAPAVLSGPPGSFFGFSVEFYRPGTDGVSVLVG
APKANTSQPGVLQGGAVYLCPWGASPTQCTPIEFDSKGSRLLESSLSSSEGEEPV

EYKSLQWFGATVRAHGSSILACAPLYSWRTEKEPLSDPVGTCYLSTDNFTRILEYA
PCRSDFSWAAGQGYCQGGFSAEFTKTGRVVLGGPGSYFWQGQILSATQEQIAES
YYPEYLINLVQGQLQTRQASSIYDDSYLGYSVAVGEFSGDDTEDFVAGVPKGNLTY
GYVTILNGSDIRSLYNFSGEQMASYFGYAVAATD.

17. The method of any one of claims 1 to 3, wherein said coronavirus protein is the SARS-CoV E protein or a fragment thereof.

18. The method of claim 17, wherein said fragment of the coronavirus is the E
c-terminal domain

19. The method of claim 18, wherein the E cytosolic tail has the amino acid sequence LTALR LCAYC CNIVN VSLVK PTVYV YSRVK NLNSS EGVPD LLV.

20. The method of any one of claims 17 to 20, wherein said PDZ domain-containing the cellular interacting protein is the PALS1 (MPP5) protein or fragment thereof.

21. The method of claim 20, Wherein said PALS1 protein comprises the amino acid sequence LEPIKEERVYESVGQYGRKTVKIVRKEEARDIPLGATVHKEMDSVIISRIVRGAAAEK
SGLLHERDDVLKINGVESREKDINEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIH
VKAHFDYDPSDDPYVPCRELGLSFQKGDILHVIS.

22. The method of any one of claims 1 to 3, wherein said coronavirus protein is the SARS-CoV M protein or a fragment thereof.

23. The method of claim 22, wherein said fragment of the coronavirus is the M
cytosolic tail (M CT).

24. The method of claim 18, wherein the M cytosolic tail has the amino acid sequence LFARTRSMWSFNPETNILLNVPLRGTIVTRPLMESELVIGAVIIRGHLRMAGHSLGRC
DIKDLPKEITVATSRTLSYYKLGASQRVGTDSGFAAYNRYRIGNYKLNTDHAGSNDN
IALLVQ

25. The method of any one of claims 22 to 24, wherein said cytoskeleton-linked cellular interacting protein is the cellular DIP/SPIN90 protein or fragment thereof.

26. The method of claims 25, wherein said fragment of the DIP/ SPIN90 protein has the amino acid sequence MELVRRNTGLSHELCRVAIGIIVGHIQASVPASSPVMEQVLLSLVEGKDLSMALPSG
QVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEGVIRCYLEELLHILTDADPEVC
KKMCKRNEFESVLALVAYYQMEHRASLRLLLLKCFGAMCSLDAAIISTLVSSVLP.

27. An anti-coronavirus composition comprising at least one purified cellular interacting protein or a fragment thereof and/or an antiviral molecule obtained by the method of claim 1.

28. A composition for the treatment and/or prevention of infection caused by a coronavirus, the composition comprising:

- at least one coronavirus protein or fragments thereof selected from the group of protein consisting of S, M and E, and - at least one cellular protein or fragments thereof.

29. Use of at least one coronavirus protein and/or at least one cellular interacting protein or cytoskeleton-linked cellular interacting protein or PDZ domain containing cellular interacting protein as defined in any one of claims I to 26, to reduce or inhibit an infection of human cells caused by a coronavirus.

30. Use of at least one coronavirus protein and/or at least one cellular interacting protein or cytoskeleton-linked cellular interacting protein or PDZ domain containing cellular interacting protein as; defined in any one of claims 1 to 26, for the treatment and/or prevention of of infection caused by a coronavirus.

31. Use of at least one coronavirus protein and/or at least one cellular interacting protein or cytoskeleton-linked cellular interacting protein or PDZ domain containing cellular interacting protein as defined in any one of claims 1 to 26, for the preparation of a composition in the treatment and/or prevention of of infection caused by a coronavirus.