CA2558659A1 - Genetically engineered canary poxvirus-based vaccine strain - Google Patents
Genetically engineered canary poxvirus-based vaccine strain Download PDFInfo
- Publication number
- CA2558659A1 CA2558659A1 CA002558659A CA2558659A CA2558659A1 CA 2558659 A1 CA2558659 A1 CA 2558659A1 CA 002558659 A CA002558659 A CA 002558659A CA 2558659 A CA2558659 A CA 2558659A CA 2558659 A1 CA2558659 A1 CA 2558659A1
- Authority
- CA
- Canada
- Prior art keywords
- virus
- inactivated
- recombinant
- genetic functions
- poxvirus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229960005486 vaccine Drugs 0.000 title abstract 4
- 241000178270 Canarypox virus Species 0.000 title abstract 2
- 241000700605 Viruses Species 0.000 abstract 4
- 230000002068 genetic effect Effects 0.000 abstract 4
- 108700026244 Open Reading Frames Proteins 0.000 abstract 2
- 230000007923 virulence factor Effects 0.000 abstract 2
- 239000000304 virulence factor Substances 0.000 abstract 2
- 230000002238 attenuated effect Effects 0.000 abstract 1
- 230000002779 inactivation Effects 0.000 abstract 1
- 230000001018 virulence Effects 0.000 abstract 1
Landscapes
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
What is described is a modified vector, such as a recombinant poxvirus, particularly recombinant canary poxvirus, having enhanced safety. The modified recombinant virus has nonessential virus-encoded genetic functions inactivated therein so that virus has attenuated virulence.
In one embodiment, the genetic functions are inactivated by deleting an open reading frame encoding a virulence factor.
In another embodiment, the genetic functions are inactivated by insertional inactivation of an open reading frame encoding a virulence factor. What is also described is a vaccine containing the modified recombinant virus having nonessential virus-encoded genetic functions inactivated therein so that the vaccine has an increased level of safety compared to known recombinant virus vaccines.
In one embodiment, the genetic functions are inactivated by deleting an open reading frame encoding a virulence factor.
In another embodiment, the genetic functions are inactivated by insertional inactivation of an open reading frame encoding a virulence factor. What is also described is a vaccine containing the modified recombinant virus having nonessential virus-encoded genetic functions inactivated therein so that the vaccine has an increased level of safety compared to known recombinant virus vaccines.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2621088A CA2621088C (en) | 1991-03-07 | 1992-03-09 | Genetically engineered fowlpox-based vaccine strain |
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US66605691A | 1991-03-07 | 1991-03-07 | |
US666,056 | 1991-03-07 | ||
US71396791A | 1991-06-11 | 1991-06-11 | |
US713,967 | 1991-06-11 | ||
US84795192A | 1992-03-06 | 1992-03-06 | |
US847,951 | 1992-03-06 | ||
CA002105277A CA2105277C (en) | 1991-03-07 | 1992-03-09 | Genetically engineered vaccine strain |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002105277A Division CA2105277C (en) | 1991-03-07 | 1992-03-09 | Genetically engineered vaccine strain |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2621088A Division CA2621088C (en) | 1991-03-07 | 1992-03-09 | Genetically engineered fowlpox-based vaccine strain |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2558659A1 true CA2558659A1 (en) | 1992-09-17 |
CA2558659C CA2558659C (en) | 2008-06-03 |
Family
ID=37310264
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002558659A Expired - Lifetime CA2558659C (en) | 1991-03-07 | 1992-03-09 | Genetically engineered canary poxvirus-based vaccine strain |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2558659C (en) |
-
1992
- 1992-03-09 CA CA002558659A patent/CA2558659C/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2558659C (en) | 2008-06-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |