CA2553369A1 - Compositions pharmaceutiques a base d'anticholinergiques et de pegsunercept - Google Patents

Compositions pharmaceutiques a base d'anticholinergiques et de pegsunercept Download PDF

Info

Publication number: CA2553369A1
Authority: CA; Canada
Prior art keywords: pharmaceutical composition; composition according; inhalable; salts; formulation
Prior art date: 2004-02-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002553369A

Other languages

English (en)

Inventor

Michel Pairet

Christopher John Montague Meade

Michael P. Pieper

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Boehringer Ingelheim International GmbH

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-02-20

Filing date

2005-02-18

Publication date

2005-09-01

2005-02-18 Application filed by Individual filed Critical Individual

2005-09-01 Publication of CA2553369A1 publication Critical patent/CA2553369A1/fr

Status Abandoned legal-status Critical Current

Links

239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 30
108010027220 PEGylated soluble tumor necrosis factor receptor I Proteins 0.000 title claims abstract description 11
229950000867 pegsunercept Drugs 0.000 title claims abstract description 11
239000000812 cholinergic antagonist Substances 0.000 title claims abstract description 9
229940065524 anticholinergics inhalants for obstructive airway diseases Drugs 0.000 title claims abstract description 8
239000013543 active substance Substances 0.000 claims description 36
239000000203 mixture Substances 0.000 claims description 36
239000000843 powder Substances 0.000 claims description 25
238000009472 formulation Methods 0.000 claims description 24
239000000546 pharmaceutical excipient Substances 0.000 claims description 24
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims description 17
150000003839 salts Chemical class 0.000 claims description 14
239000000725 suspension Substances 0.000 claims description 13
239000002775 capsule Substances 0.000 claims description 12
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
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QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
239000007951 isotonicity adjuster Substances 0.000 description 1
229960001021 lactose monohydrate Drugs 0.000 description 1
239000012669 liquid formulation Substances 0.000 description 1
239000001630 malic acid Substances 0.000 description 1
235000011090 malic acid Nutrition 0.000 description 1
229960002160 maltose Drugs 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
238000002156 mixing Methods 0.000 description 1
150000004682 monohydrates Chemical class 0.000 description 1
229910017604 nitric acid Inorganic materials 0.000 description 1
208000037916 non-allergic rhinitis Diseases 0.000 description 1
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
229960001609 oxitropium bromide Drugs 0.000 description 1
LCELQERNWLBPSY-KHSTUMNDSA-M oxitropium bromide Chemical compound [Br-].C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3[N+]([C@H](C2)[C@@H]2[C@H]3O2)(C)CC)=CC=CC=C1 LCELQERNWLBPSY-KHSTUMNDSA-M 0.000 description 1
244000052769 pathogen Species 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
239000002831 pharmacologic agent Substances 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920001451 polypropylene glycol Polymers 0.000 description 1
229920000136 polysorbate Polymers 0.000 description 1
229940068965 polysorbates Drugs 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
230000036515 potency Effects 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
238000003825 pressing Methods 0.000 description 1
235000019260 propionic acid Nutrition 0.000 description 1
229960004063 propylene glycol Drugs 0.000 description 1
235000013772 propylene glycol Nutrition 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
230000002040 relaxant effect Effects 0.000 description 1
206010039083 rhinitis Diseases 0.000 description 1
229910052710 silicon Inorganic materials 0.000 description 1
239000010703 silicon Substances 0.000 description 1
238000009097 single-agent therapy Methods 0.000 description 1
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
239000004299 sodium benzoate Substances 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
235000010356 sorbitol Nutrition 0.000 description 1
239000008347 soybean phospholipid Substances 0.000 description 1
238000001694 spray drying Methods 0.000 description 1
229960004793 sucrose Drugs 0.000 description 1
239000001117 sulphuric acid Substances 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
238000011287 therapeutic dose Methods 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
MQLXPRBEAHBZTK-SEINRUQRSA-M tiotropium bromide hydrate Chemical compound O.[Br-].C[N+]1(C)[C@H]2C[C@@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 MQLXPRBEAHBZTK-SEINRUQRSA-M 0.000 description 1
229930003799 tocopherol Natural products 0.000 description 1
239000011732 tocopherol Substances 0.000 description 1
235000019149 tocopherols Nutrition 0.000 description 1
229940074410 trehalose Drugs 0.000 description 1
102000003298 tumor necrosis factor receptor Human genes 0.000 description 1
235000019155 vitamin A Nutrition 0.000 description 1
239000011719 vitamin A Substances 0.000 description 1
235000019165 vitamin E Nutrition 0.000 description 1
239000011709 vitamin E Substances 0.000 description 1
229940046009 vitamin E Drugs 0.000 description 1
229940045997 vitamin a Drugs 0.000 description 1
239000000811 xylitol Substances 0.000 description 1
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
235000010447 xylitol Nutrition 0.000 description 1
229960002675 xylitol Drugs 0.000 description 1
QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, ***e
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pulmonology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Otolaryngology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Zoology (AREA)
Cell Biology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CA002553369A 2004-02-20 2005-02-18 Compositions pharmaceutiques a base d'anticholinergiques et de pegsunercept Abandoned CA2553369A1 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP04003940		2004-02-20
EP04003940.6		2004-02-20
PCT/EP2005/001690 WO2005079796A1 (fr)	2004-02-20	2005-02-18	Compositions pharmaceutiques a base d'anticholinergiques et de pegsunercept

Publications (1)

Publication Number	Publication Date
CA2553369A1 true CA2553369A1 (fr)	2005-09-01

Family

ID=34878168

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002553369A Abandoned CA2553369A1 (fr)	2004-02-20	2005-02-18	Compositions pharmaceutiques a base d'anticholinergiques et de pegsunercept

Country Status (4)

Country	Link
EP (1)	EP1718304A1 (fr)
JP (1)	JP2007523117A (fr)
CA (1)	CA2553369A1 (fr)
WO (1)	WO2005079796A1 (fr)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW555765B (en) *	1996-07-09	2003-10-01	Amgen Inc	Low molecular weight soluble tumor necrosis factor type-I and type-II proteins
DE19921693A1 (de) *	1999-05-12	2000-11-16	Boehringer Ingelheim Pharma	Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika
EP1397134A2 (fr) *	2001-05-25	2004-03-17	Boehringer Ingelheim Pharma GmbH & Co.KG	Combinaison d'un agoniste de recepteur de dopamine d2 et de tiotropium ou d'un derive de celui-ci, destinee au traitement des voies respiratoires obstructives et d'autres maladies inflammatoires
ES2276942T3 (es) *	2001-05-25	2007-07-01	BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG	Combinacion de un inhibidor de pde4 y tiotropio o un derivado del mismo para tratar vias respiratorias obstructivas y otras enfermedades inflamatorias.

2005
- 2005-02-18 CA CA002553369A patent/CA2553369A1/fr not_active Abandoned
- 2005-02-18 WO PCT/EP2005/001690 patent/WO2005079796A1/fr not_active Application Discontinuation
- 2005-02-18 EP EP05715395A patent/EP1718304A1/fr not_active Withdrawn
- 2005-02-18 JP JP2006553542A patent/JP2007523117A/ja active Pending

Also Published As

Publication number	Publication date
WO2005079796A1 (fr)	2005-09-01
JP2007523117A (ja)	2007-08-16
EP1718304A1 (fr)	2006-11-08

Legal Events

Date	Code	Title	Description
2010-02-18	FZDE	Dead

Publication	Publication Date	Title
US7851483B2 (en)	2010-12-14	Medicaments comprising steroids and a novel anticholinergic
US20050186175A1 (en)	2005-08-25	Pharmaceutical compositions based on benzilic acid esters and soluble TNF receptor fusion proteins
US20060205758A1 (en)	2006-09-14	Method for reducing the mortality rate
US20040192675A1 (en)	2004-09-30	Pharmaceutical compositions containing tiotropium salts and antihistamines and their use
US20040002502A1 (en)	2004-01-01	Medicament combinations comprising heterocyclic compounds and a novel anticholinergic
CA2498727C (fr)	2012-01-10	Procede d'amelioration de la capacite de patients souffrant de maladies pulmonaires a participer et tirer profit de programmes de rehabilitation pulmonaire
AU2004262902B2 (en)	2009-07-30	Medicaments for inhalation comprising betamimetics and an anticholinergic
US20030203918A1 (en)	2003-10-30	Pharmaceutical composition comprising an anticholinergic and a heterocyclic compound
US20060034776A1 (en)	2006-02-16	Inhalable medicaments containing a new anticholinergic, corticosteroids, and betamimetics
US7507745B2 (en)	2009-03-24	Pharmaceutical compositions based on fluorenecarboxylic acid esters and soluble TNF receptor fusion proteins
US20050260139A1 (en)	2005-11-24	Pharmaceutical compositions based on anticholinergics and CCR2 receptor antagonists
US20060110330A1 (en)	2006-05-25	Inhalable pharmaceutical compositions containing an anticholinergic, formoterol, and a steroid
US20060251656A1 (en)	2006-11-09	New pharmaceutical compositions based on anticholinergics and anti-tnf antibodies
US20070021333A1 (en)	2007-01-25	Pharmaceutical compositions based on anticholinergics and soluble tnf receptor fusion proteins
US20060189524A1 (en)	2006-08-24	Pharmaceutical compositions based on anticholinergics and pegsunercept
US20050187157A1 (en)	2005-08-25	Pharmaceutical compositions based on anticholinergics and pegsunercept
CA2553369A1 (fr)	2005-09-01	Compositions pharmaceutiques a base d'anticholinergiques et de pegsunercept
CA2552903A1 (fr)	2005-09-01	Compositions pharmaceutiques a base d'anticholinergiques et de pegsunercept
CA2515534A1 (fr)	2004-08-26	Nouvelles compositions pharmaceutiques a base d'anticholinergiques et d'inhibiteurs de l'enzyme tace
US20060228305A1 (en)	2006-10-12	Pharmaceutical compositions based on anticholinergics and inhibitors of tnf alpha synthesis or action