CA2549456A1 - Process of preparing glycolaldehyde - Google Patents
Process of preparing glycolaldehyde Download PDFInfo
- Publication number
- CA2549456A1 CA2549456A1 CA002549456A CA2549456A CA2549456A1 CA 2549456 A1 CA2549456 A1 CA 2549456A1 CA 002549456 A CA002549456 A CA 002549456A CA 2549456 A CA2549456 A CA 2549456A CA 2549456 A1 CA2549456 A1 CA 2549456A1
- Authority
- CA
- Canada
- Prior art keywords
- formaldehyde
- group
- glycolaldehyde
- carbon atoms
- phospha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- WGCNASOHLSPBMP-UHFFFAOYSA-N Glycolaldehyde Chemical compound OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 title claims abstract description 91
- 238000000034 method Methods 0.000 title claims abstract description 36
- 230000008569 process Effects 0.000 title claims abstract description 34
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims abstract description 161
- 239000003446 ligand Substances 0.000 claims abstract description 54
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims abstract description 38
- 239000003054 catalyst Substances 0.000 claims abstract description 38
- 239000010948 rhodium Substances 0.000 claims abstract description 36
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 31
- 229910052703 rhodium Inorganic materials 0.000 claims abstract description 24
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000000203 mixture Substances 0.000 claims abstract description 23
- -1 2-phospha-tricyclo[3.3.1.1{3,7}]-decyl group Chemical group 0.000 claims abstract description 11
- 125000005842 heteroatom Chemical group 0.000 claims abstract description 10
- 125000004437 phosphorous atom Chemical group 0.000 claims abstract description 8
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229910002091 carbon monoxide Inorganic materials 0.000 claims abstract description 7
- 125000001183 hydrocarbyl group Chemical group 0.000 claims abstract description 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000001257 hydrogen Substances 0.000 claims abstract description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 6
- 238000006243 chemical reaction Methods 0.000 claims description 39
- 125000000217 alkyl group Chemical group 0.000 claims description 19
- 150000001450 anions Chemical class 0.000 claims description 17
- 239000002904 solvent Substances 0.000 claims description 13
- 239000008346 aqueous phase Substances 0.000 claims description 12
- 239000012074 organic phase Substances 0.000 claims description 9
- 125000003118 aryl group Chemical group 0.000 claims description 7
- 239000012429 reaction media Substances 0.000 claims description 7
- 150000001408 amides Chemical class 0.000 claims description 6
- 125000002877 alkyl aryl group Chemical group 0.000 claims description 5
- 125000002947 alkylene group Chemical group 0.000 claims description 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 5
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 2
- 150000003254 radicals Chemical class 0.000 description 14
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 13
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 12
- 239000012071 phase Substances 0.000 description 12
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- HDIJZFORGDBEKL-UHFFFAOYSA-N 2,3,4-trimethylbenzoic acid Chemical compound CC1=CC=C(C(O)=O)C(C)=C1C HDIJZFORGDBEKL-UHFFFAOYSA-N 0.000 description 10
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Natural products P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 description 10
- 239000002253 acid Substances 0.000 description 10
- GGRQQHADVSXBQN-FGSKAQBVSA-N carbon monoxide;(z)-4-hydroxypent-3-en-2-one;rhodium Chemical compound [Rh].[O+]#[C-].[O+]#[C-].C\C(O)=C\C(C)=O GGRQQHADVSXBQN-FGSKAQBVSA-N 0.000 description 10
- QENJZWZWAWWESF-UHFFFAOYSA-N tri-methylbenzoic acid Natural products CC1=CC(C)=C(C(O)=O)C=C1C QENJZWZWAWWESF-UHFFFAOYSA-N 0.000 description 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
- 229930040373 Paraformaldehyde Natural products 0.000 description 9
- 239000007795 chemical reaction product Substances 0.000 description 9
- 238000007037 hydroformylation reaction Methods 0.000 description 9
- 238000005259 measurement Methods 0.000 description 9
- 230000000052 comparative effect Effects 0.000 description 8
- 229910000073 phosphorus hydride Inorganic materials 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 239000011541 reaction mixture Substances 0.000 description 7
- 150000007513 acids Chemical class 0.000 description 6
- 125000004429 atom Chemical group 0.000 description 6
- UORVGPXVDQYIDP-UHFFFAOYSA-N borane Chemical compound B UORVGPXVDQYIDP-UHFFFAOYSA-N 0.000 description 6
- XPEOTZMXIWGSAB-UHFFFAOYSA-N 2-butylhexanamide Chemical compound CCCCC(C(N)=O)CCCC XPEOTZMXIWGSAB-UHFFFAOYSA-N 0.000 description 5
- ORILYTVJVMAKLC-UHFFFAOYSA-N adamantane Chemical compound C1C(C2)CC3CC1CC2C3 ORILYTVJVMAKLC-UHFFFAOYSA-N 0.000 description 5
- 150000003003 phosphines Chemical class 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical class OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 125000001424 substituent group Chemical group 0.000 description 4
- IDJPNVXQFUVAEK-UHFFFAOYSA-N 8-icosyl-1,3,5,7-tetramethyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane Chemical compound C(CCCCCCCCCCCCCCCCCCC)P1C2(CC3(OC(CC1(O3)C)(O2)C)C)C IDJPNVXQFUVAEK-UHFFFAOYSA-N 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 3
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 3
- 229910000085 borane Inorganic materials 0.000 description 3
- 150000001735 carboxylic acids Chemical class 0.000 description 3
- 239000000460 chlorine Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 3
- 238000005984 hydrogenation reaction Methods 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 3
- 239000002243 precursor Substances 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- DSYQHWPNJZFRCU-UHFFFAOYSA-N 1,3,5,7-tetramethyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane Chemical compound C1C(P2)(C)OC3(C)CC2(C)OC1(C)O3 DSYQHWPNJZFRCU-UHFFFAOYSA-N 0.000 description 2
- DJXHXILQRDQZGU-UHFFFAOYSA-N 2-phosphatricyclo[3.3.1.13,7]decane Chemical class C1C(P2)CC3CC1CC2C3 DJXHXILQRDQZGU-UHFFFAOYSA-N 0.000 description 2
- QBUBJAXSVUKLBJ-UHFFFAOYSA-N 9-icosyl-9-phosphabicyclo[3.3.1]nonane Chemical compound C1CCC2CCCC1P2CCCCCCCCCCCCCCCCCCCC QBUBJAXSVUKLBJ-UHFFFAOYSA-N 0.000 description 2
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 239000002841 Lewis acid Substances 0.000 description 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
- WPPOGHDFAVQKLN-UHFFFAOYSA-N N-Octyl-2-pyrrolidone Chemical compound CCCCCCCCN1CCCC1=O WPPOGHDFAVQKLN-UHFFFAOYSA-N 0.000 description 2
- 101100030361 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) pph-3 gene Proteins 0.000 description 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 2
- 208000007542 Paresis Diseases 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- 239000007868 Raney catalyst Substances 0.000 description 2
- 229910000564 Raney nickel Inorganic materials 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical class OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- YRKCREAYFQTBPV-UHFFFAOYSA-N acetylacetone Chemical compound CC(=O)CC(C)=O YRKCREAYFQTBPV-UHFFFAOYSA-N 0.000 description 2
- 150000001336 alkenes Chemical class 0.000 description 2
- 229910000147 aluminium phosphate Chemical class 0.000 description 2
- 235000010233 benzoic acid Nutrition 0.000 description 2
- 235000013877 carbamide Nutrition 0.000 description 2
- DIOQZVSQGTUSAI-UHFFFAOYSA-N decane Chemical compound CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 description 2
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 150000007517 lewis acids Chemical class 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 208000012318 pareses Diseases 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 238000000638 solvent extraction Methods 0.000 description 2
- 239000001117 sulphuric acid Substances 0.000 description 2
- 235000011149 sulphuric acid Nutrition 0.000 description 2
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 2
- 150000003672 ureas Chemical class 0.000 description 2
- GGQQNYXPYWCUHG-RMTFUQJTSA-N (3e,6e)-deca-3,6-diene Chemical compound CCC\C=C\C\C=C\CC GGQQNYXPYWCUHG-RMTFUQJTSA-N 0.000 description 1
- QFCSTMJALGVENX-UHFFFAOYSA-N 1,3,5,7-tetramethyl-8-octyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane Chemical compound CC12OC3(CC(OC(C1)(P3CCCCCCCC)C)(O2)C)C QFCSTMJALGVENX-UHFFFAOYSA-N 0.000 description 1
- CZASMUMJSKOHFJ-UHFFFAOYSA-N 1-bromoicosane Chemical compound CCCCCCCCCCCCCCCCCCCCBr CZASMUMJSKOHFJ-UHFFFAOYSA-N 0.000 description 1
- ULVHAZFBJJXIDO-UHFFFAOYSA-N 2,4,6-tri(propan-2-yl)benzoic acid Chemical compound CC(C)C1=CC(C(C)C)=C(C(O)=O)C(C(C)C)=C1 ULVHAZFBJJXIDO-UHFFFAOYSA-N 0.000 description 1
- LXFQSRIDYRFTJW-UHFFFAOYSA-N 2,4,6-trimethylbenzenesulfonic acid Chemical compound CC1=CC(C)=C(S(O)(=O)=O)C(C)=C1 LXFQSRIDYRFTJW-UHFFFAOYSA-N 0.000 description 1
- FFFIRKXTFQCCKJ-UHFFFAOYSA-N 2,4,6-trimethylbenzoic acid Chemical compound CC1=CC(C)=C(C(O)=O)C(C)=C1 FFFIRKXTFQCCKJ-UHFFFAOYSA-N 0.000 description 1
- RYVDOHQOYOKGLD-UHFFFAOYSA-N 2-butan-2-yl-3-methylpentanamide Chemical compound CCC(C)C(C(N)=O)C(C)CC RYVDOHQOYOKGLD-UHFFFAOYSA-N 0.000 description 1
- ANWLUDATAFQJQF-UHFFFAOYSA-N 8-dodecyl-1,3,5,7-tetramethyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane Chemical compound C(CCCCCCCCCCC)P1C2(CC3(OC(CC1(O3)C)(O2)C)C)C ANWLUDATAFQJQF-UHFFFAOYSA-N 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- 239000007848 Bronsted acid Substances 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- 229910006111 GeCl2 Inorganic materials 0.000 description 1
- KWYHDKDOAIKMQN-UHFFFAOYSA-N N,N,N',N'-tetramethylethylenediamine Chemical compound CN(C)CCN(C)C KWYHDKDOAIKMQN-UHFFFAOYSA-N 0.000 description 1
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical class O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 238000004639 Schlenk technique Methods 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- CUJRVFIICFDLGR-UHFFFAOYSA-N acetylacetonate Chemical compound CC(=O)[CH-]C(C)=O CUJRVFIICFDLGR-UHFFFAOYSA-N 0.000 description 1
- 125000005595 acetylacetonate group Chemical group 0.000 description 1
- 229940117913 acrylamide Drugs 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000005882 aldol condensation reaction Methods 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 125000003302 alkenyloxy group Chemical group 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 description 1
- 125000004414 alkyl thio group Chemical group 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 125000003710 aryl alkyl group Chemical group 0.000 description 1
- 125000005110 aryl thio group Chemical group 0.000 description 1
- 125000004104 aryloxy group Chemical group 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 150000001559 benzoic acids Chemical class 0.000 description 1
- 125000002619 bicyclic group Chemical group 0.000 description 1
- UWTDFICHZKXYAC-UHFFFAOYSA-N boron;oxolane Chemical compound [B].C1CCOC1 UWTDFICHZKXYAC-UHFFFAOYSA-N 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 125000004663 dialkyl amino group Chemical group 0.000 description 1
- 125000004986 diarylamino group Chemical group 0.000 description 1
- YDVNLQGCLLPHAH-UHFFFAOYSA-N dichloromethane;hydrate Chemical compound O.ClCCl YDVNLQGCLLPHAH-UHFFFAOYSA-N 0.000 description 1
- MWPIIMNHWGOFBL-UHFFFAOYSA-N dichloromethane;toluene Chemical compound ClCCl.CC1=CC=CC=C1 MWPIIMNHWGOFBL-UHFFFAOYSA-N 0.000 description 1
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
- SBZXBUIDTXKZTM-UHFFFAOYSA-N diglyme Chemical compound COCCOCCOC SBZXBUIDTXKZTM-UHFFFAOYSA-N 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 238000001030 gas--liquid chromatography Methods 0.000 description 1
- 150000004820 halides Chemical group 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- CETVQRFGPOGIQJ-UHFFFAOYSA-N lithium;hexane Chemical compound [Li+].CCCCC[CH2-] CETVQRFGPOGIQJ-UHFFFAOYSA-N 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- MEXKFCWMWJZDMF-UHFFFAOYSA-N n,n-dibutylacetamide Chemical compound CCCCN(C(C)=O)CCCC MEXKFCWMWJZDMF-UHFFFAOYSA-N 0.000 description 1
- DKLYDESVXZKCFI-UHFFFAOYSA-N n,n-diphenylacetamide Chemical compound C=1C=CC=CC=1N(C(=O)C)C1=CC=CC=C1 DKLYDESVXZKCFI-UHFFFAOYSA-N 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 150000002826 nitrites Chemical class 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- WJIBZZVTNMAURL-UHFFFAOYSA-N phosphane;rhodium Chemical compound P.[Rh] WJIBZZVTNMAURL-UHFFFAOYSA-N 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 239000010970 precious metal Substances 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 150000003283 rhodium Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
- B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
- B01J31/2442—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring comprising condensed ring systems
- B01J31/2461—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring comprising condensed ring systems and phosphine-P atoms as ring members in the condensed ring system or in a further ring
- B01J31/248—Bridged ring systems, e.g. 9-phosphabicyclononane
- B01J31/2485—Tricyclic systems, e.g. phosphaadamantanes and hetero analogues
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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Abstract
The invention provides a process of preparing glycolaldehyde by reacting formaldehyde with hydrogen and carbon monoxide in the presence of a catalyst composition which is based on, a) a source of rhodium, and b) a ligand of general formula R1P-R2(I), wherein R1 is a bivalent radical that together with the phosphorous atom to which it is attached is an optionally substituted 2-phospha-tricyclo[3.3.1.1{3,7}]-decyl group, wherein from 1 to 5 of the carbon atoms has been replaced by a heteroatom, and wherein R2 is a monovalent radical which is an optionally substituted hydrocarbyl group having from 1 to 40 carbon atoms; a catalyst composition of use in said process; and a process of preparing ethylene glycol from the glycolaldehyde thus prepared.
Description
Process of preparing Glycolaldehyde The present invention relates to a process of preparing glycolaldehyde and a process of preparing ethylene glycol from the glycolaldehyde thus prepared.
The reaction of an unsaturated substrate with carbon monoxide and hydrogen is known as hydroformylation. It has been disclosed in the past that glycolaldehyde, which is a useful intermediate for the preparation of ethylene glycol, may be prepared by a hydroformylation reaction of formaldehyde employing a rhodium catalyst. However, the preparation of glycolaldehyde in this way is hindered in that the rhodium catalyst also promotes.hydrogenation of formaldehyde to methanol, lowering glycolaldehyde yields.
Attempts have been made to suppress methanol production and increase selectivity to the glycolaldehyde product and in this regard it has been found that good yields of glycolaldehyde can be achieved by use of rhodium catalysts containing aryl-substituted phosphine ligands such as triphenylphosphine, optionally in combination with protonoic acids (e. g. see Pure&Appl.
Chem., Vol. 62, No. 4, pp. 661-669, 1990). However, such aryl-substituted ligands suffer from the disadvantage that they are unstable in the reaction conditions, lessening their effectiveness.
A further limitation on this method of preparing glycolaldehyde, in particular when it is to be used as an intermediate in the preparation of ethylene glycol, is that good results~are only obtained when using para-formaldehyde in non-aqueous conditions and that use of the cheaper aqueous formaldehyde (formaline) gives lower conversion and selectivity to glyCOlaldehyde. This is' thought to be due to the instability of the catalyst in aqueous conditions. Indeed, the difficulty in hydrofo rmylating aqueous. formaldehyde represents a major obstacl a to the commercialisation of this approach for the pro duction of ethylene glycol.
European patent application EP-A-0331512 reviews the use of a rhodium-phosphine ligand complex, wherein the phoshin a ligand is a triorganophoshine, in the hydrofo rmylation of aqueous formaldehyde to glycola ldehyde, which can then be used to prepare ethylene glycol.
A process has now been developed for hydroformylating ,formaldehyde that is based on the use of a rhodium catalyst and a specific form of phosphine ligand. The process has performance advantages when compared to known IS rhodium catalysts having aryl-substituted phosphine.
ligands. Moreover, the catalysts of the present invention are mor a stable in aqueous conditions than catalysts contain ing aryl-substituted phosphine ligands, and may readily be used to convert aqueous formaldehyde to glycolaldehyde .
The present invention provides a process of preparing glycola ldehyde which comprises reacting formaldehyde~with hydroge n and carbon monoxide in the presence of a catalys t composition which is based on a) a source of rhodium, and b) a ligand of general formula R1P-R2 (I) wherein R1 is a bivalent radical that together with the phosphorous atom to which it is attached is an optionally substituted 2-phospha-tricyclo[3.3.1.13,7}]-decyl group, wherein from 1 to 5 of the carbon atoms has been replaced by a he teroatom, and wherein R2 is a monovalent radical which is an optionally substituted hydrocarbyl group having from.l to 40 carbon atoms.
The catalyst composition of the present invention requires a source of rhodium. Convenient sources of rhodium include rhodium salts of mineral acids, such as salts of sulphuric acid, nitric acid and phosphoric acid;
s alts of sulphonic acids, such as methane sulphonic acid and para-toluenesulphonic acid; and salts of carboxylic acids, in particular those having up to 6 carbon atoms, such as acetic acid, propionic acid and trifluoracetic acid. Alternatively, the source. of rhodium may contain rhodium in a zero-valent form, complexed by ligands such as carbon monoxide, acetylacetonates and phosphine ligands. The source of rhodium metal may contain a mixture of anioi2s and uncharged ligands, e.g. as in Rh.Cl {CO) 2 or Rh (acac) (CO) 2.
In the ligand of general formula (I), R1 represents a bivalent radical that together with the phosphorus atom to which it is attached is an optionally substituted 2 -phospha-tricyclo[3.3.1.1(3,7}]decyl group, wherein from 1 to 5 of the carbon atoms has been replaced by a heteroatom.
Tricyclo[3.3.1.1(3,7}]decane is the systematic name for a compound more commonly known as adamantane.
Therefore, for ease of reference, in the present description the optionally substituted 2-phospha-tricyclo[3.3.1.1(3,7}decyl group, or a derivative thereof, may be referred to as a "2-PA" group (as.in 2-phosphadamantyl.group).
In the ligands employed in the present invention, from 1 to 5 of the carbon atoms in the "2-PA" group have been replaced by a heteroatom. Examples of heteroatoms that may conveniently be used are oxygen and sulphur atoms, oxygen atoms being preferred.. The from 1 to 5 carbon atoms replaced by heteroatoms are preferably those located a t positions 4, 6, 8, 9, or 10 of the "2-PA"
group. Most preferably 3 carbon atoms of the "2-PA" group have been replaced by heteroatoms, preferably at the 6, 9 and 10 positions .
Preferably, the "2-PA" group is substituted on one or more of t he 1, 3, 5 or 7 positions with a monovalent radical of up to 20 atoms, preferably a radical .
comprising 1' to 10 carbon atoms and more preferably 1 to 6 carbon atoms. Examples of suitable manovalent radicals include methyl, ethyl; propyl, phenyl, and 4-dodecylphenyl groups, methyl and ethyl groups being preferred.~More preferably, the "2-PA" group is substi-tuted on each of the l, 3, 5 and 7~positions. Most preferabl y the substituents on each of the 1, 3, 5~and 7 positions are identical'.
Ligands that have given particularly good results in the present invention are those wherein the bivalent radical Ri to.gether with the phosphorous atom~to which it is attach ed is a.2-phospha-1,3,5,7-tetralkyl-6,9,10-trioxa-tr icyclo[3.3.1.1{3,7y]-decyl group, as depicted in Figure I:=
Me Me P
~ Mel ~ _O
Me Figure, 1.
In th a ligand of general formula (I), R2 is a monovalent radical which is an optionally substituted hydrocarb y1 group having from 1 to 90 carbon atoms. The hydrocarbyl groups may be substituted or unsubstituted, straight or branched chain, saturated or unsaturated;
preferred such hydrocarbyl groups being alkyl, cycloalkyl, aryl, alkaryl and aralkyl groups. Where the hydrocarbyl group is substituted, substituents which the hydrocarbyl group may conveniently carry may be independently selected from one or more of halogen atoms (e. g. fluorine or chlorine), alkoxy, alkenyloxy, aryloxy, hydroxy, dialkylamido, diarylamido, alkylthio, arylthio, alkyl suphonyl, alkylsulphinyl; alkoxycarbonyl, dialkylamino and diarylamino groups. Herein as substituents suitably an alkyl moiety has from 1 to 4 carbon atoms, an alkenyl moiety has from 2 to 4 carbon atoms, and an aryl group has from 6 to 12 carbon atoms, and i s especially phenyl. Preferred substituents are dialkylamido and diarylamido groups.
In a first preferred embodiment, the process of the present invention employs a ligand wherein the monovalent radical R2 is an, alkyl group having in the range of from 4 to 34 carbon atoms. Preferably, the alkyl group R2 of this embodiment comprises at least 6 carbon atoms, most preferably at least 10, especially at least 12, carbon atoms; and preferably up to 28 carbon atoms, more preferably up to 22 carbon atoms. The alkyl group may be , linea r or branched, however it will preferably be linear.
The ligands of this embodiment are preferred as they displ ay a high conversion t.o glycol aldehyde and may enhance stability of the catalyst. They perform particularly well in the hydroformylation of formaldehyde in no n-aqueous conditions.
L igands that may be conveniently used in the present invention according to the first preferred embodiment include 2-phospha-2-hexyl-1,3,5,7-tetramethyl-6,9,10-triox a-tricyclo[3.3.1.1{3,7}]-decane, 2-phospha-2-octyl-1,3,5,7 -tetramethyl-6,9,10-trioxa-tricyclo[3.3.1.1{3,7}]-decane, 2-phospha-2-dodecyl-1,3,5,7-tetramethyl-6,9,10-trioxa-tricyclo[3.3.1.1{3,7}]-decane, and 2-phospha-2-icosyl-1,3,5,7-tetramethyl-6,9,10-trioxa-S tricyclo[3.3.1.1{3,7}]-decane.
In a second preferred embodiment, the process of the present invention employs a ligand wherein the monovalent radical R2 'is of general formula -R3_C(p)NR4R5 (II) wherein R3 is an alkylene group and R4 and R5 independently represent an alkyl, cycloalkyl, aryl or alkaryl group, or R4 and R5 together represent a bivalent bridging group. Conveniently, alkylene group R3 is a methylene, ethylene, propylene or butylene group, most conveniently an ethylene group. Preferably, R4 and R5 independently represent an aryl group, for example phenyls or an alkyl group, preferably an alkyl group having from 1 to 22 carbon atoms. Examples of alkyl . groups that may conveniently be used include methyl, ethyl, propyl, butyl, and pentyl groups. Zigands wherein R2 is of general formula (II) are preferred as they display an excellent conversion~to glycolaldehyde and are particularly advantageous for hydroformylation reactions performed with aqueous formaldehyde.
2S Ligands that may be conveniently used in the present inventi on according to the second preferred embodiment include 2-phospha-2-(ethyl-N,N-diethylamido)-1,3,5,7-tetramethyl-6,9,10-trioxa-tricyclo[3.3.1.1{3,7}]-decane, 2-phospha-2-(ethyl-N,N-diphenylamido)-1,3,5,7-tetramethyl-6,9,10-trioxa-tricyclo[3.3.1.1{3,7}]-decane, and 2-phospha-2-(ethyl-N,N-dimethylamido)-1,3,5,7-tetramethyl-6,9,10-trioxa-tricyclo[3.3.1.1{3,7}]-decane.
_ 7 The ligands of general formula (T) may be prepared by coupling an optionally substituted 2-phospha-tricyclo[3.3.1.1(3,7}]-decane, wherein from 1 to 5 of the carbon atoms has been replaced by a heteroatom, with a suitable RZ group precursor. The 2-phospha-tricyclo[3.3.1.1{3,7}]-decane may conveniently be prepared by analogous chemistry to that described in US-A-3,050,531, wherein for instance 2-phospha-1,3,.5,7-tetramethyl-6,9,10-trioxa-tricyclo[3.3.1.1[3,7}]-decane is prepared b y reacting 2,4-pentanedione with phosphine in the presence of hydrochloric acid. Similar chemistry is also discussed in chapter 3 of "PRECIOUS METAL .
COMPLEXES OF SOME NOVEL FUNCTIONALISED SECONDARY AND
TERTIARY PHOS PHINES" by Ms. Joanne H Downing (thesis submitted to the University of Bristol on November 1992).
Examples of R2 group precursors include compounds of formula R2-X, wherein X is a halide, for example a chloride or bromide, which may conveniently be used when preparing lig ands of general formula (I) wherein R2 is an alkyl group; for example by reaction of an R3-X compound with 2-phosph a-1,3,5,~7-tetramethyl-6,9,10-trioxa-tricyclo[3.3.1.1{3,7}]-decane or its borane adduct.
Alternatively, when R2 is of general .formula -R3-C(0)NR4R5 (II), the R2 group precursor may conveniently be an N,N-disubstituted alkenylamide. For example, liga nds wherein R3 is an ethylene group and R4 and R5 are a1 kyl groups may be prepared by reaction of a dialkyl-acryl amide with a "2-PA" group in the presence of acid, e.g. acetic acid. Other ligands according to the present invention may be prepared by analogous chemistry, as will be understood by those skilled in the art.
The catalyst compositions employed in the present invention may optionally comprise a source of anions c) _ g _ as a further catalyst component. Preferred anions are anions of protic acids having a pKa (measured at 18°C in water) of less than 6, preferably less than 4. The anions derived f ram these acids do not or only weakly co-y ordinate with the rhodium, by which it is meant that little or no covalent interaction occurs between the anion and the rhodium. Catalysts.comprising such anions exhibit good activity.
Examples of suitable anions include those derived from Bronsted acids, such as phosphoric acid and sulphuric acid; as well as anions derived from sulphonic acids e.g. methanesulphonic acid, trifluoromethane sulphonic acid, p-toluenesulphonic acid and 2,4,6-trimethylbenzenesulphonic acid; and anions derived from carboxylic acids, a . g. 2, 4, 6-trimethylbenzoic acid, 2, 4, 6 tri-isopropylbenzoic acid; 9-antracene carboxylic acid and halogenated carboxylic acids. such as trifluoroacetic acid ~,6-dichlorobenzoic acid, and 2,6 bis(trifluororriethyl)benzoic acid. Particularly good results.have been obtained using alkyl-substituted benzoic a rids, especially Cl to C4 alkyl-substituted benzoic acids, as a source of anions.
Also suitable are complex anions, such as the anions generated by the combination of a Lewis acid such as BF3, B{C6F5)3, A1C13, SnF~, Sn(CF3S03)2, SnCl~ or-GeCl2, with a erotic acid, preferably having a pKa of less than 5, such as a sulphonic acid, e.g. CF3S03H or CH3S03H or a hydrohalogenic acid such as HF or HC1., or a combination of a Lewis acid with an alcohol. Examples of such comply anions are BF4-, SnCl3-, [SnCI2.CF~S03]- and PF6-.
The molar ratio of carbon monoxide to hydrogen supplied to the process of the present invention is not critical and may vary over a wide range, for example of from 5:95 to 95:5, preferably of from 30:70 to 80:20.
However, it is generally preferred to use a gas stream in which the molar rati o of CO:H~ is at least 1:1, since this minimises the formation of methanol. The process is preferably conducted under pressure, conveniently in the range of from 5 to 200 bar X0.5 to 20 MPa) and preferably in the range of from 10 to 50 bar (1 to 5 MPa). Higher pressures may be used, however they are generally considered uneconomical. Inert gasses may also be present in the gas stream but as this leads to an increase in total pressure it is generally undesirable.
The hydroformyla t ion reaction of the present invention may be conveniently carried out at moderate temperatures, preferably in the range of from 22 to 180 °C, more preferably SO to 130 °C. The use of a temperature as low a s possible commensurate with the desired reaction rat a is preferred since at higher temperatures the glycolaldehyde product is susceptible to undergo side reactions, e.g. aldol condensation reactions.
The reaction time for the process of the invention is of course dependent on the temperature and pressure conditions utilised. It has been generally found that the reaction time ma y be in the range of from 1. to 10 hours, preferably 1 to 6 hours, especially 2 to.5 hours.
The quantity in which the catalyst system is used in the present invention is not critical and may vary within wide limits. However, the amount of mole atom of rhodium metal per mole of formaldehyde will preferably be in the range of from 1:1 to 1:10, more preferably from 1:10 to 1:105, and even more preferably from 1:100 to 1:104.
For the preparat.i on of catalyst systems employed in the present invention, the amount of ligand of general formula (I) is gener ally applied in an excess to the amount of rhodium, expressed as moles of ligand per mole atom of rhodium. Typically the amount of ligand is selected such that per mole atom of rhodium 1 to 20 moles .of ligand are present. However, for a preferred catalyst system the molar amount of ligand per mole of rhodium is preferably in the range of from 2 to 10, more preferably in the range of from 2 to 5. When present the amount of the anion source c), whilst not critical, may range from 1 to 500, preferably from 1 to 150, and more preferably from 1 to 20 moles per mole atom of rhodium.
The process of the present..~nvention may be carried out in the presence of~a solvent. Examples of solvents that may conveniently be used include nitrites, pyridine, substituted or unsubstituted ureas, for example N,N,N',N'-tetrasubstituted ureas, and substituted or unsubstituted amides, for example N,N-disubstituted amides.
The formaldehyde may be introduced into the reaction system in any suitable form, or it may be generated in situ. A convenient source of formaldehyde is para-formaldehyde. Further, it is an advantageous feature of the present invention that good results are achieved when aqueous formaldehyde is employed as the source of formaldehyde. Accordingly, in a preferred process according to the present invention the source of formaldehyde is~aqueous formaldehyde.
Where the source of formaldehyde is aqueous formaldehyde it is further preferred that the process is .performed in a reaction medium comprising an aqueous phase and an organic phase, wherein the organic phase and aqueous phase are immiscible at 22 °C. For the avoidance of doubt, by irnmiscible it ~is meant that on standing at 22 °C the organic phase and aqueous phase will separate into two,distinct layers. A reaction medium comprising an aqueous phase and an organic phase is preferred as on completion of the reaction the catalyst will reside in the organic~phase, whilst the glycolaldehyde product will reside in the aqueous phase, and thus the product may readily be separated from the catalyst by phase separation. Such an approach is possible in the present invention as the catalyst compositions are more stable in aqueous conditions than known catalysts based on aryl-substituted phosphine ligands.
. Where the process is performed in a reaction medium comprising an aqueous phase arid an organic phase, the solvent of the organi c phase may conveniently be a water-immiscible amide solvent. Examples of water-immiscible amide solvents that can be employed in the present IS invention are those comprising long chain alkyl moieties and includes N-alkyl- 2-pyrrolidones wherein the alkyl group comprises at least 7 carbon atoms, preferably in the range of from 8 t o 20 carbon atoms, N,N-dialkyl-acetamides, in which each alkyl group has in the range of from 1 to 10 carbon a toms, preferably from 1 to 6 Garbom atoms, and N,N-diaryl -acetamides, preferably N,N-diphenylacetamide. Examples of water-immiscible amide solvents that have given particularly good results when employed in the present invention include N-octyl-pyrrolidone and N,N-dibutyl-acetamide.
A particularly preferred embodiment of the present invention is wherein the process i,s performed in a reaction medium comprising an aqueous phase and an organic phase comprising a water-immiscible amide solvent, and wherein in the ligand of general 'formula R1P-R2 (I), the monovalent radical R2 is of general formula -R3-C(0)NR~R5 (II).
The rhodium-containing catalyst compositions described herein above were specifically developed for use in the process of the present invention.
Catalyst compositi ans of this type fall within the wide-ranging definitio n of metal-ligand complexes described in US-A-2003 /0092935 for the hydroformyl,ation ~of olefins such as ex-olefins, internal olefins, and internal branched olef ins. The preferred catalyst compositions for use i n the process of the present invention are distant from the preferred metal-ligand complexes. of US-A-2003/0092935 and display an excellent activity in the hydrof ormylation of formaldehyde, a very different substrate, in both non-aqueous and aqueous conditions. Catalyst compositions in which the monovalent.radical R2, of the ligand (I), is of general formula -R3-C(O)NR4R5 (II) perform especially well in aqueous conditions for example when formalin is used as the substrate, or when water is present in the reaction medium. Accordingly, the present invention further provides a catalyst composition obtainable by combining a) a source of rhodium, b) a ligand of general formula ~~-P-R2 ( I ) wherein R1 is a bivalent radical that together with the phosphorous atom to which it is attached is an optionally substituted 2-phospha -tricyclo[3.3.1.1{3,7}]-decyl group, wherein from 1 to 5 of the carbon atoms has been replaced by a heteroatom, and wherein R2 is a monovalent radical which is an optionall y substituted alkyl group having from 10 to 40 carbon atoms, or is, preferably, of the general formula -R3-C(0)NR4R5, wherein R3 is an alkylene group and R4 and R5 independently represent an alkyl, cycloalkyl, aryl or alkaryl group or R4 and R5 together represent a bivalent bridging group, and optionally c) a source of anions. Within these definitions of R2, preferred catalyst compositions as described herein before with respect to the process of the present invention are similarly preferred as the catalyst composition of the invention.
An important use of glycolaldehyde is its conversion to ethylene .glycol and the present invention still further provides a process of preparing ethylene glycol by hydrogenating glycolaldehyde prepared by the hydroformylation process described herein above.
Hydrogenation catalysts of use in the conversion of glycolaldehyde to ethylene glycol are well known in the art, for example palladium, platinum or nickel catalysts, often in heterogeneous form. Where glycolaldehyde is prepared in non-aqueous conditions, the selected hydrogenation catalyst may be added directly to the reaction mixture resulting from the preparation of glycolaldehyde with no work-up. procedure, and. gaseous hydrogen introduced. Alternatively, the reaction mixture may be worked-up before the glycolaldehyde is hydrogenated, e.g. by extraction with a suitable solvent such as water or ethylene glycol itself, and the resulting solution then hydrogenated in conventional manner. This approach is particularly convenient when the glycolaldehyde is prepared from aqueous formaldehyde in a reaction medium comprising an aqueous phase as has now been made possible by means of the present invention.
The invention will be further understood from the following illustrative examples.
Ligand Synthesis The following examples, which were performed under an atmosphere of purified argon using standard Schlenk techniques, illustrate a typical preparation of a ligand according to the present invention wherein (1) R2 is an alkyl group (2-phospha-2-icosyl-1,3,5,7-tetramethyl-6,9,10-trioxa-trieyclo[3.3.1.1{3,7}]-decane), and (ii) R2 is of general formula (II) {2-phospha-2-(ethyl-N,N-dimethylamido)-1,3,5,7-tetramethyl-6,9,10-.trioxa-tricyclo [ 3 . 3 .1 .1 ( 3, 7 } ] -decane ) .
(1) Synthesis of 2-phospha - 2-icosyl-1,3,5,7-tetramethyl-6,9,10-trioxa-tricyclo[3.3.1.1{3,7}]-decane.
A borane adduct of 2-phospha-1,3,5,7-tetramethyl-6,9,10-trioxa-tricyclo[3.3.1.1(3,7}]-decane was prepared by adding BH3.THF (70 ml of 1M solution in THF) to a solution of 2-phospha-1,3,5,7-tetramethyl-6,9,10-trioxa-.
tricyclo [ 3 . 3 .1.1 { 3, 7 } ] -decane ( ~0 mmol ) in THF at 0°C .
The reaction mixture was al 1 owed to warm to room temperature and stir for two hours after which time the .
solvent was removed in vacu o to yield the borane adduct.
To a solution of this adduct (16 mmol in THF) a solution of hexyl-lithium ~(6.4 ml, 2.5M in hexane) was added at a temperature of - 70 °C and the reaction mixture allowed to slowly w arm to - 20 °C over a period of 1 hour. After retooling to - 70 °C, a solution of 1-bromo-icosane (16 mmol in T HF) was added. The reaction mixture was then allowed to warm to ambient temperature and stirred for 2 hours bef ore diethylamine (3 ml) was added arid the reaction mixture then refluxed for 12 hours. On completion of the reaction the solvent was removed in vacuo. The product was then isolated by solvent extraction in dichl oromethane-toluene and water, the toluene fractions being evaporated to leave a solid residue that was washed with methanol to yield 2-phospha-2-icosyl-1,3,5,7-tet ramethyl-6,9,10-trioxa-tricyclo[3.3.1.1{3,7}]-decane (96 0).
(ii) Synthesis of 2-phospha-2-(ethyl-N,N-dimethylamido)-1,3,5,7-tetramethyl- 6,9,'10-trioxa-tricyclo[3.3.1.1{3,7}]-decane.
2-Phospha-1,3,5,7-tetramethyl-6,9,10-trioxa-tricyclo[3.3.1.1{3,7}]-decane (40 mmol) and N, N dimethylacrylam.i.de (100 mmol) were introduced into a Schlenk-tube contain ing a mixture of toluene and acetic acid, and heated to a temperature of 115 °C. After 18 hours the reaction mixture was cooled to 80 °C and the solvents evaporated in vacuo. The residue was then .
dissolved in triethylamine and the mixture heated to a temperature of 100 °C for 2.5 hours after which the resulting homogeneou s mixture was cooled to ambient temperature. The product was then isolated by solvent extraction with toluene and water, the toluene fractions being evaporated to yield 2-phospha-2-(ethyl-N,N- .
, dimethylamido) -1, 3, 5, 7-te,tramethyl-6, 9, 10-trioxa-tricyclo [ 3 . 3 . 1. 1 { 3, 7 } ] =decane ( 7 9 0 ) .
Hydroformylation of formaldehyde The following examples were performed in a magnetically stirred 250 ml autoclave. The autoclave was charged with reactan is and solvent after which air was removed and the auto clave pressurised with carbon monoxide and hydroge n, each to a partial pressure of 30bar (3MPa). The oontents of the autoclave were then heated to reaction temperature. Upon completion of the reaction, the contents were cooled and the conversion of formaldehyde, and yield of glycolaldehyde, was determined by means of gas-liquid chromatography using di-ethylene glycol dimethylether as an internal standard. All ligands were prepared using analogous chemistry to that described for ligands (i) and (ii) abov e.
Example 1 ("2-PA"-C20 ligand in non-aqueous conditions) The autoclave was charged with 0.17 mol of formaldehyde, in the form of para-formaldehyde, 62 ml (0.58 mol) of N-methyl-pyrrol idone, 0.25 mmo1 of rhodiumdicarbonylacetonylacet one (Rh(acac)(CO)2), 0.50 mmol of 2-phospha-2-icosyl-1,3,5,7-tetramethyl-6,9,10-trioxa-tricyclo[3.3.1.1{3,7}]-decane, and 9.1 mmol of trimethylbenzoic acid. The contents of the autoclave were then heated to a temperature of 110 °C and maintained at that temperature for 2 hours.
Conversion of formaldehyde was 1000 and the yield of glycolaldehyde, calculated on formaldehyde intake, was 76~. The initial reaction rat a was calculated by measurement of the pressure drop to be 595 mol CO/mol Rh.h.
Example 2 ("2-PA"-CZO ligand in aqueous conditions) The autoclave was charged with 0.17 mol of formaldehyde, in the form of para-formaldehyde, 35 ml (0.22 mol) of dibutyl-acetami de, 25 ml of demineralised 2S water, 0.25 mmol of Rh (acac) (CO) 2, 0 .53 mmol of 2-phospha-2-icosyl-1,3,5,7-tetramethyl-6,9,10-trioxa-tricyclo[3.3.1.1{3,7}]-decane, and 9.1 mmo1 of trimethylbenzoic acid. The contents of the autoclave were heated to a temperature of 110 °C and maintained at that temperature for 5 hours.
Conversion of formaldehyde was 64 o and the yield of glycolaldehyde in the two-phase reaction product, calculated on formaldehyde i make, was 45 0. The initial reaction rate was calculated by measurement of the pressure drop to be 115 mot CO/mol Rh.h Example 3 ("2-PA"-CHzCH2C {0) NMez ligand in non-aqueous conditions) The autoclave was charged with 0.18 mol of formaldehyde, in the form of pares-formaldehyde, 23 ml (0.15 mol) of di-sec-butyl-acetamide, 0.25 mm~l of Rh{a.cac)(CO)2, 0.49 mmol of 2-phospha-2-(ethyl-N,N-dimethylamido)-1,3,5,7-tetramethyl-6,9,10-trioxa-tricyclo[3.3.1.1{3,7}]-decane, and 9.1 mmol of trimethylbenzoic acid. The contents of the autoclave were then heated to a temperature of 100 °C and maintained at that temperature for 3 hours.
Conversion of formaldehyde was 72 o and the yie"ld of glycolaldehyde in the single-phase reaction product, calculated on formaldehyde intake, was 69 0. The initial reaction rate was calculated by measurement of the pressure drop to be 275 mot CO/mol Rh.h.
Example 4 ( "2-PA"-CH~CH2C (0) NMe2 ligand in non-aqueous conditions ) The autoclave was charged with 0.25 mol of formaldehyde, in the form of pares-formaldehyde, 35 ml (0.26 mol) of N,N'-dimethylpropylenurea, 0.10 mmol of Rh(acac)(CO)2, 0.20 mmol of 2-phospha-2-(ethyl-N,N-dimethylamido)-1,3,5,7-tetramethyl-6,9,10-trioxa-tricyclo[3.3.1.1{3,7}]-decane, and 3.1 mmol of trimethylbenzoic acid. The contents of the autoclave were then heated to a temperature of 90 °C and maintained at that temperature~for 5 hours.
Conversion of formaldehyde was 73 o and the yield of glycolaldehyde in the singl e-phase reaction product, calculated on .formaldehyde intake, was 71 %. The initial _ 18 _ reaction rate was calculated by measurement of the pressure drop to be 595 mol CO/mol Rh.h.
Example 5 ("2-PA"-CH2CH2C1g ligand in non-aqueous conditions) The autoclave was charged with 0.25 mol of formaldehyde, in the form of para-formaldehyde, 35 ml (0.26 mol) of N,N'-dimethylpropylenurea, 0.10 mmol of Rh(acac)(CO)2, 0.20 mmol of 2-phospha-2-octyl-1,3,5,7-tetramethyl -6,9,10-trioxa-tricyclo[.3.3.1.1{3,7}]-decane, and 3.1 mmol of trimethylbenzoic acid. The contents of the autoclave were then heated to a temperature of 90 °C
and maintained at that temperature for 5 hours.
Conversion of formaldehyde was 69 o and the yield of glycolaldehyde in the single-phase reaction product, calculated on formaldehyde intake, was 66 0.~ The initial reaction rate was calculated by measurement of the pressure drop to be 518 mol CO/mol Rh.h.
Example 6 ("2-PA"-CH2CH2C(0)NMe2 ligand in aqueous conditions) The autoclave was charged with 0.15 mol of formaldehyde, in the form of a formaline solution (37 0 formaldehyde in water), 37 ml (0.22 mol) of dibutyl-acetamide, 7.5 ml of demineralised water, 0.49 mmol of Rh(acac)(CO)2, 0.96 mmol of 2-phospha-2-(ethyl-N,N-dimethylamido) -1, 3,,5, 7-tetramethyl-6, 9, 10-trioxa-tricyclo[3.3.1.1{3,7}]-decane~, and 9.1 mmol of trimethylbenzoic acid. The contents of the autoclave were heated to a temperature of 90 °C and maintained at that temperature for 5 hours.
Conversion of formaldehyde was 90 o and the yield of glycolaldehyde in the two-phase reaction product, calculated on formaldehyde intake, was 90 0. The initial reaction rate was calculated by measurement of the pressure drop to be 170 mol CO/mo1 Rh.h.
Example 7 ("2-PA"- CH~CH~C(0)NPh~ ligand in aqueous conditions) The autoclave was charged with 0.15. mol of formaldehyde, in the form of a formaline solution (37 formaldehyde), 37 ml (0.~2 mol) of dibutyl-acetamide, 7.5 ml of demineralised water, 0.44 mrnol of Rh(acac)(CO)2, 0.89 mmol of 2-phospha-2-(ethyl-N,N-diphenylamido)-1, 3, 5, 7-tetramethyl-6, 9, 10-trioxa-tricyclo [3 . 3 . 1 . 1 ( 3, 7 } ) -decane, and 9.1 mmol of trimethyl~enzoic acid. The contents of the autoclave were heated to a temperature of 110 °C and maintained at that temp erature for 3 hours.
Conversion of formaldehyde was 100 o and the yield of glycolaldehyde in the two-phase re action product, calculated on formaldehyde intake, was 52 0. The initial reaction rate was calculated by measurement of the pressure drop to be 180 mol CO/mo~ Rh.h.
Comparative Example A
(PPh3 ligand in non-aqueous condit ions) The autoclave was charged with 0.17 mol of formaldehyde, in the form of para- formaldehyde, 37 ml (0.24 mol) of dibutyl-acetamide, 0.25 mmol of Rh(acac)(CO)2, 0.52 mmol of triphe nylphosphine, and 9.3 mmol of trimethylbenzoic acid. The contents of the autoclave were then heated to a temperature of 90 °C and maintained at that temperature fo r 10 hours.
Conversion of formaldehyde was 61 '% and the yield of glycolaldehyde in the single-phase reaction product, calculated on formaldehyde intake, was 40 0. The initial reaction rate was calculated by measurement of the pressure drop to be 75 mol CO/mol Rh.h 2p _ Comparative Example B
(PPh3 ligand in aqueous conditions) The autoclave was char ged with 0.17 mol of formaldehyde, in the form of para-formaldehyde, 37 ml (0.22 mol)~of ~dibutyl-acet amide, 12.5 ml of demineralised water, 0.25 mmol of Rh.(acac) (CO) 2,. 0. 52 mmol of triphenylphosphine, and 9.1 mmol of trimethylbenzoic acid. The contents of the autoclave were heated to a temperature of 90 °C and maintained at that temperature for 10 hours.
Conversion of formaldehyde was 54 % and the yield of glycolaldehyde in the two-phase reaction product, calculated on formaldehyde intake, was 25 %. The reaction rate was calculated by measurement of the pressure drop to be 51 mol CO/mol Rh.h.
Comparative Example C
(9-icosyl-9-phosphabicyclo[3.3.1]nonane ligand in aqueous conditions) The autoclave was charged with 0.17 mol of formaldehyde, in the form of para-formaldehyde, 37 ml (0.19 mol) of N-octyl-pyrrolidone, 25 ml of demineralised water, 0.25 mmol of Rh (acac) (CO) 2, 0. 52 mmol of 9-icosyl-9-phosphabicyclo[3.3.1]nonane, and 9.1 mmol of . trimethylbenzoic acid. The contents of the autoclave were heated to a temperature of 110 °C and maintained at that temperature for 5 hours.
Conversion of formaldehyde was 17 % and the yield of glycolaldehyde in the two-phase reaction product, calculated on formaldehyde intake, Was 6 %.
Comparative Example D
(9-CH2CH2C(0)NMe2-9-phosphabicyclo[3.3.1]nonane liga.nd in aqueous conditions) The autoclave was charged with 0.17.mo1 of formaldehyde, in the form of para-formaldehyde, 37 ml (0.22 mol) of dibutyl-acetamide, 25 m1 of demineralised water, 0.25 mmol of Rh (acac) (CO) 2, 0. 50 mmol of 9-phospha-9-(ethyl-N,N-dimethylamido-bicyclo[3.3.1]nonane, and 9.1 mmol of trimethylbenzoic acid. The contents of the autoclave were then heated to a temperature of 110 °C
and maintained at that temperature for 5~ hours.
Conversion of formaldehyde was 3 o and the yield of glycolaldehyde in the two-phase react ion product, calculated on formaldehyde intake, wa s 0 0.
The above examples demonstrate th a t catalyst compositions according to the present invention display a superior performance to comparative compositions containing a triphenylphosphine ligan d under both~aqueous and non-aqueous conditions (e.g. comp are Examples 1 and 3 with Comparative Example A, and Examples 2 and 4 with Comparative Example B), and to catalysts based on other forms of bicyclic phosphine-containin g ligand (see Comparative Examples C and D). Moreover, from Examples 4 and 5 it.can also be seen that catal~rst compositions of general formula (I) wherein R2 is of general formula -R3-C (0) NR4R5 continue to display a good level of performance even under aqueous~condit ions.
Hvdroaenation to Ethvlene alvcol To demonstrate the ease with which glycolaldehyde prepared according to the present invention may be converted to ethylene glycol, an aqueous phase separated from a hydroformylation reaction pexf ormed under conditions analogous to those of Example 2 ( "2-PA"-CZo ligand in aqueous conditions) was treated with Raney Nickel slurry. The aqueous phase (25 ml, 9.5owt glycolaldehyde) was mixed with Raney Nickel slurry (2m1) and stirred for 15 hours at a temperature 40°C, then.
treated with hydrogen at a pressu re of 50 bar (5Mpa). The conversion from glycolaldehyde to ethylene glycol was 90 0 .
The reaction of an unsaturated substrate with carbon monoxide and hydrogen is known as hydroformylation. It has been disclosed in the past that glycolaldehyde, which is a useful intermediate for the preparation of ethylene glycol, may be prepared by a hydroformylation reaction of formaldehyde employing a rhodium catalyst. However, the preparation of glycolaldehyde in this way is hindered in that the rhodium catalyst also promotes.hydrogenation of formaldehyde to methanol, lowering glycolaldehyde yields.
Attempts have been made to suppress methanol production and increase selectivity to the glycolaldehyde product and in this regard it has been found that good yields of glycolaldehyde can be achieved by use of rhodium catalysts containing aryl-substituted phosphine ligands such as triphenylphosphine, optionally in combination with protonoic acids (e. g. see Pure&Appl.
Chem., Vol. 62, No. 4, pp. 661-669, 1990). However, such aryl-substituted ligands suffer from the disadvantage that they are unstable in the reaction conditions, lessening their effectiveness.
A further limitation on this method of preparing glycolaldehyde, in particular when it is to be used as an intermediate in the preparation of ethylene glycol, is that good results~are only obtained when using para-formaldehyde in non-aqueous conditions and that use of the cheaper aqueous formaldehyde (formaline) gives lower conversion and selectivity to glyCOlaldehyde. This is' thought to be due to the instability of the catalyst in aqueous conditions. Indeed, the difficulty in hydrofo rmylating aqueous. formaldehyde represents a major obstacl a to the commercialisation of this approach for the pro duction of ethylene glycol.
European patent application EP-A-0331512 reviews the use of a rhodium-phosphine ligand complex, wherein the phoshin a ligand is a triorganophoshine, in the hydrofo rmylation of aqueous formaldehyde to glycola ldehyde, which can then be used to prepare ethylene glycol.
A process has now been developed for hydroformylating ,formaldehyde that is based on the use of a rhodium catalyst and a specific form of phosphine ligand. The process has performance advantages when compared to known IS rhodium catalysts having aryl-substituted phosphine.
ligands. Moreover, the catalysts of the present invention are mor a stable in aqueous conditions than catalysts contain ing aryl-substituted phosphine ligands, and may readily be used to convert aqueous formaldehyde to glycolaldehyde .
The present invention provides a process of preparing glycola ldehyde which comprises reacting formaldehyde~with hydroge n and carbon monoxide in the presence of a catalys t composition which is based on a) a source of rhodium, and b) a ligand of general formula R1P-R2 (I) wherein R1 is a bivalent radical that together with the phosphorous atom to which it is attached is an optionally substituted 2-phospha-tricyclo[3.3.1.13,7}]-decyl group, wherein from 1 to 5 of the carbon atoms has been replaced by a he teroatom, and wherein R2 is a monovalent radical which is an optionally substituted hydrocarbyl group having from.l to 40 carbon atoms.
The catalyst composition of the present invention requires a source of rhodium. Convenient sources of rhodium include rhodium salts of mineral acids, such as salts of sulphuric acid, nitric acid and phosphoric acid;
s alts of sulphonic acids, such as methane sulphonic acid and para-toluenesulphonic acid; and salts of carboxylic acids, in particular those having up to 6 carbon atoms, such as acetic acid, propionic acid and trifluoracetic acid. Alternatively, the source. of rhodium may contain rhodium in a zero-valent form, complexed by ligands such as carbon monoxide, acetylacetonates and phosphine ligands. The source of rhodium metal may contain a mixture of anioi2s and uncharged ligands, e.g. as in Rh.Cl {CO) 2 or Rh (acac) (CO) 2.
In the ligand of general formula (I), R1 represents a bivalent radical that together with the phosphorus atom to which it is attached is an optionally substituted 2 -phospha-tricyclo[3.3.1.1(3,7}]decyl group, wherein from 1 to 5 of the carbon atoms has been replaced by a heteroatom.
Tricyclo[3.3.1.1(3,7}]decane is the systematic name for a compound more commonly known as adamantane.
Therefore, for ease of reference, in the present description the optionally substituted 2-phospha-tricyclo[3.3.1.1(3,7}decyl group, or a derivative thereof, may be referred to as a "2-PA" group (as.in 2-phosphadamantyl.group).
In the ligands employed in the present invention, from 1 to 5 of the carbon atoms in the "2-PA" group have been replaced by a heteroatom. Examples of heteroatoms that may conveniently be used are oxygen and sulphur atoms, oxygen atoms being preferred.. The from 1 to 5 carbon atoms replaced by heteroatoms are preferably those located a t positions 4, 6, 8, 9, or 10 of the "2-PA"
group. Most preferably 3 carbon atoms of the "2-PA" group have been replaced by heteroatoms, preferably at the 6, 9 and 10 positions .
Preferably, the "2-PA" group is substituted on one or more of t he 1, 3, 5 or 7 positions with a monovalent radical of up to 20 atoms, preferably a radical .
comprising 1' to 10 carbon atoms and more preferably 1 to 6 carbon atoms. Examples of suitable manovalent radicals include methyl, ethyl; propyl, phenyl, and 4-dodecylphenyl groups, methyl and ethyl groups being preferred.~More preferably, the "2-PA" group is substi-tuted on each of the l, 3, 5 and 7~positions. Most preferabl y the substituents on each of the 1, 3, 5~and 7 positions are identical'.
Ligands that have given particularly good results in the present invention are those wherein the bivalent radical Ri to.gether with the phosphorous atom~to which it is attach ed is a.2-phospha-1,3,5,7-tetralkyl-6,9,10-trioxa-tr icyclo[3.3.1.1{3,7y]-decyl group, as depicted in Figure I:=
Me Me P
~ Mel ~ _O
Me Figure, 1.
In th a ligand of general formula (I), R2 is a monovalent radical which is an optionally substituted hydrocarb y1 group having from 1 to 90 carbon atoms. The hydrocarbyl groups may be substituted or unsubstituted, straight or branched chain, saturated or unsaturated;
preferred such hydrocarbyl groups being alkyl, cycloalkyl, aryl, alkaryl and aralkyl groups. Where the hydrocarbyl group is substituted, substituents which the hydrocarbyl group may conveniently carry may be independently selected from one or more of halogen atoms (e. g. fluorine or chlorine), alkoxy, alkenyloxy, aryloxy, hydroxy, dialkylamido, diarylamido, alkylthio, arylthio, alkyl suphonyl, alkylsulphinyl; alkoxycarbonyl, dialkylamino and diarylamino groups. Herein as substituents suitably an alkyl moiety has from 1 to 4 carbon atoms, an alkenyl moiety has from 2 to 4 carbon atoms, and an aryl group has from 6 to 12 carbon atoms, and i s especially phenyl. Preferred substituents are dialkylamido and diarylamido groups.
In a first preferred embodiment, the process of the present invention employs a ligand wherein the monovalent radical R2 is an, alkyl group having in the range of from 4 to 34 carbon atoms. Preferably, the alkyl group R2 of this embodiment comprises at least 6 carbon atoms, most preferably at least 10, especially at least 12, carbon atoms; and preferably up to 28 carbon atoms, more preferably up to 22 carbon atoms. The alkyl group may be , linea r or branched, however it will preferably be linear.
The ligands of this embodiment are preferred as they displ ay a high conversion t.o glycol aldehyde and may enhance stability of the catalyst. They perform particularly well in the hydroformylation of formaldehyde in no n-aqueous conditions.
L igands that may be conveniently used in the present invention according to the first preferred embodiment include 2-phospha-2-hexyl-1,3,5,7-tetramethyl-6,9,10-triox a-tricyclo[3.3.1.1{3,7}]-decane, 2-phospha-2-octyl-1,3,5,7 -tetramethyl-6,9,10-trioxa-tricyclo[3.3.1.1{3,7}]-decane, 2-phospha-2-dodecyl-1,3,5,7-tetramethyl-6,9,10-trioxa-tricyclo[3.3.1.1{3,7}]-decane, and 2-phospha-2-icosyl-1,3,5,7-tetramethyl-6,9,10-trioxa-S tricyclo[3.3.1.1{3,7}]-decane.
In a second preferred embodiment, the process of the present invention employs a ligand wherein the monovalent radical R2 'is of general formula -R3_C(p)NR4R5 (II) wherein R3 is an alkylene group and R4 and R5 independently represent an alkyl, cycloalkyl, aryl or alkaryl group, or R4 and R5 together represent a bivalent bridging group. Conveniently, alkylene group R3 is a methylene, ethylene, propylene or butylene group, most conveniently an ethylene group. Preferably, R4 and R5 independently represent an aryl group, for example phenyls or an alkyl group, preferably an alkyl group having from 1 to 22 carbon atoms. Examples of alkyl . groups that may conveniently be used include methyl, ethyl, propyl, butyl, and pentyl groups. Zigands wherein R2 is of general formula (II) are preferred as they display an excellent conversion~to glycolaldehyde and are particularly advantageous for hydroformylation reactions performed with aqueous formaldehyde.
2S Ligands that may be conveniently used in the present inventi on according to the second preferred embodiment include 2-phospha-2-(ethyl-N,N-diethylamido)-1,3,5,7-tetramethyl-6,9,10-trioxa-tricyclo[3.3.1.1{3,7}]-decane, 2-phospha-2-(ethyl-N,N-diphenylamido)-1,3,5,7-tetramethyl-6,9,10-trioxa-tricyclo[3.3.1.1{3,7}]-decane, and 2-phospha-2-(ethyl-N,N-dimethylamido)-1,3,5,7-tetramethyl-6,9,10-trioxa-tricyclo[3.3.1.1{3,7}]-decane.
_ 7 The ligands of general formula (T) may be prepared by coupling an optionally substituted 2-phospha-tricyclo[3.3.1.1(3,7}]-decane, wherein from 1 to 5 of the carbon atoms has been replaced by a heteroatom, with a suitable RZ group precursor. The 2-phospha-tricyclo[3.3.1.1{3,7}]-decane may conveniently be prepared by analogous chemistry to that described in US-A-3,050,531, wherein for instance 2-phospha-1,3,.5,7-tetramethyl-6,9,10-trioxa-tricyclo[3.3.1.1[3,7}]-decane is prepared b y reacting 2,4-pentanedione with phosphine in the presence of hydrochloric acid. Similar chemistry is also discussed in chapter 3 of "PRECIOUS METAL .
COMPLEXES OF SOME NOVEL FUNCTIONALISED SECONDARY AND
TERTIARY PHOS PHINES" by Ms. Joanne H Downing (thesis submitted to the University of Bristol on November 1992).
Examples of R2 group precursors include compounds of formula R2-X, wherein X is a halide, for example a chloride or bromide, which may conveniently be used when preparing lig ands of general formula (I) wherein R2 is an alkyl group; for example by reaction of an R3-X compound with 2-phosph a-1,3,5,~7-tetramethyl-6,9,10-trioxa-tricyclo[3.3.1.1{3,7}]-decane or its borane adduct.
Alternatively, when R2 is of general .formula -R3-C(0)NR4R5 (II), the R2 group precursor may conveniently be an N,N-disubstituted alkenylamide. For example, liga nds wherein R3 is an ethylene group and R4 and R5 are a1 kyl groups may be prepared by reaction of a dialkyl-acryl amide with a "2-PA" group in the presence of acid, e.g. acetic acid. Other ligands according to the present invention may be prepared by analogous chemistry, as will be understood by those skilled in the art.
The catalyst compositions employed in the present invention may optionally comprise a source of anions c) _ g _ as a further catalyst component. Preferred anions are anions of protic acids having a pKa (measured at 18°C in water) of less than 6, preferably less than 4. The anions derived f ram these acids do not or only weakly co-y ordinate with the rhodium, by which it is meant that little or no covalent interaction occurs between the anion and the rhodium. Catalysts.comprising such anions exhibit good activity.
Examples of suitable anions include those derived from Bronsted acids, such as phosphoric acid and sulphuric acid; as well as anions derived from sulphonic acids e.g. methanesulphonic acid, trifluoromethane sulphonic acid, p-toluenesulphonic acid and 2,4,6-trimethylbenzenesulphonic acid; and anions derived from carboxylic acids, a . g. 2, 4, 6-trimethylbenzoic acid, 2, 4, 6 tri-isopropylbenzoic acid; 9-antracene carboxylic acid and halogenated carboxylic acids. such as trifluoroacetic acid ~,6-dichlorobenzoic acid, and 2,6 bis(trifluororriethyl)benzoic acid. Particularly good results.have been obtained using alkyl-substituted benzoic a rids, especially Cl to C4 alkyl-substituted benzoic acids, as a source of anions.
Also suitable are complex anions, such as the anions generated by the combination of a Lewis acid such as BF3, B{C6F5)3, A1C13, SnF~, Sn(CF3S03)2, SnCl~ or-GeCl2, with a erotic acid, preferably having a pKa of less than 5, such as a sulphonic acid, e.g. CF3S03H or CH3S03H or a hydrohalogenic acid such as HF or HC1., or a combination of a Lewis acid with an alcohol. Examples of such comply anions are BF4-, SnCl3-, [SnCI2.CF~S03]- and PF6-.
The molar ratio of carbon monoxide to hydrogen supplied to the process of the present invention is not critical and may vary over a wide range, for example of from 5:95 to 95:5, preferably of from 30:70 to 80:20.
However, it is generally preferred to use a gas stream in which the molar rati o of CO:H~ is at least 1:1, since this minimises the formation of methanol. The process is preferably conducted under pressure, conveniently in the range of from 5 to 200 bar X0.5 to 20 MPa) and preferably in the range of from 10 to 50 bar (1 to 5 MPa). Higher pressures may be used, however they are generally considered uneconomical. Inert gasses may also be present in the gas stream but as this leads to an increase in total pressure it is generally undesirable.
The hydroformyla t ion reaction of the present invention may be conveniently carried out at moderate temperatures, preferably in the range of from 22 to 180 °C, more preferably SO to 130 °C. The use of a temperature as low a s possible commensurate with the desired reaction rat a is preferred since at higher temperatures the glycolaldehyde product is susceptible to undergo side reactions, e.g. aldol condensation reactions.
The reaction time for the process of the invention is of course dependent on the temperature and pressure conditions utilised. It has been generally found that the reaction time ma y be in the range of from 1. to 10 hours, preferably 1 to 6 hours, especially 2 to.5 hours.
The quantity in which the catalyst system is used in the present invention is not critical and may vary within wide limits. However, the amount of mole atom of rhodium metal per mole of formaldehyde will preferably be in the range of from 1:1 to 1:10, more preferably from 1:10 to 1:105, and even more preferably from 1:100 to 1:104.
For the preparat.i on of catalyst systems employed in the present invention, the amount of ligand of general formula (I) is gener ally applied in an excess to the amount of rhodium, expressed as moles of ligand per mole atom of rhodium. Typically the amount of ligand is selected such that per mole atom of rhodium 1 to 20 moles .of ligand are present. However, for a preferred catalyst system the molar amount of ligand per mole of rhodium is preferably in the range of from 2 to 10, more preferably in the range of from 2 to 5. When present the amount of the anion source c), whilst not critical, may range from 1 to 500, preferably from 1 to 150, and more preferably from 1 to 20 moles per mole atom of rhodium.
The process of the present..~nvention may be carried out in the presence of~a solvent. Examples of solvents that may conveniently be used include nitrites, pyridine, substituted or unsubstituted ureas, for example N,N,N',N'-tetrasubstituted ureas, and substituted or unsubstituted amides, for example N,N-disubstituted amides.
The formaldehyde may be introduced into the reaction system in any suitable form, or it may be generated in situ. A convenient source of formaldehyde is para-formaldehyde. Further, it is an advantageous feature of the present invention that good results are achieved when aqueous formaldehyde is employed as the source of formaldehyde. Accordingly, in a preferred process according to the present invention the source of formaldehyde is~aqueous formaldehyde.
Where the source of formaldehyde is aqueous formaldehyde it is further preferred that the process is .performed in a reaction medium comprising an aqueous phase and an organic phase, wherein the organic phase and aqueous phase are immiscible at 22 °C. For the avoidance of doubt, by irnmiscible it ~is meant that on standing at 22 °C the organic phase and aqueous phase will separate into two,distinct layers. A reaction medium comprising an aqueous phase and an organic phase is preferred as on completion of the reaction the catalyst will reside in the organic~phase, whilst the glycolaldehyde product will reside in the aqueous phase, and thus the product may readily be separated from the catalyst by phase separation. Such an approach is possible in the present invention as the catalyst compositions are more stable in aqueous conditions than known catalysts based on aryl-substituted phosphine ligands.
. Where the process is performed in a reaction medium comprising an aqueous phase arid an organic phase, the solvent of the organi c phase may conveniently be a water-immiscible amide solvent. Examples of water-immiscible amide solvents that can be employed in the present IS invention are those comprising long chain alkyl moieties and includes N-alkyl- 2-pyrrolidones wherein the alkyl group comprises at least 7 carbon atoms, preferably in the range of from 8 t o 20 carbon atoms, N,N-dialkyl-acetamides, in which each alkyl group has in the range of from 1 to 10 carbon a toms, preferably from 1 to 6 Garbom atoms, and N,N-diaryl -acetamides, preferably N,N-diphenylacetamide. Examples of water-immiscible amide solvents that have given particularly good results when employed in the present invention include N-octyl-pyrrolidone and N,N-dibutyl-acetamide.
A particularly preferred embodiment of the present invention is wherein the process i,s performed in a reaction medium comprising an aqueous phase and an organic phase comprising a water-immiscible amide solvent, and wherein in the ligand of general 'formula R1P-R2 (I), the monovalent radical R2 is of general formula -R3-C(0)NR~R5 (II).
The rhodium-containing catalyst compositions described herein above were specifically developed for use in the process of the present invention.
Catalyst compositi ans of this type fall within the wide-ranging definitio n of metal-ligand complexes described in US-A-2003 /0092935 for the hydroformyl,ation ~of olefins such as ex-olefins, internal olefins, and internal branched olef ins. The preferred catalyst compositions for use i n the process of the present invention are distant from the preferred metal-ligand complexes. of US-A-2003/0092935 and display an excellent activity in the hydrof ormylation of formaldehyde, a very different substrate, in both non-aqueous and aqueous conditions. Catalyst compositions in which the monovalent.radical R2, of the ligand (I), is of general formula -R3-C(O)NR4R5 (II) perform especially well in aqueous conditions for example when formalin is used as the substrate, or when water is present in the reaction medium. Accordingly, the present invention further provides a catalyst composition obtainable by combining a) a source of rhodium, b) a ligand of general formula ~~-P-R2 ( I ) wherein R1 is a bivalent radical that together with the phosphorous atom to which it is attached is an optionally substituted 2-phospha -tricyclo[3.3.1.1{3,7}]-decyl group, wherein from 1 to 5 of the carbon atoms has been replaced by a heteroatom, and wherein R2 is a monovalent radical which is an optionall y substituted alkyl group having from 10 to 40 carbon atoms, or is, preferably, of the general formula -R3-C(0)NR4R5, wherein R3 is an alkylene group and R4 and R5 independently represent an alkyl, cycloalkyl, aryl or alkaryl group or R4 and R5 together represent a bivalent bridging group, and optionally c) a source of anions. Within these definitions of R2, preferred catalyst compositions as described herein before with respect to the process of the present invention are similarly preferred as the catalyst composition of the invention.
An important use of glycolaldehyde is its conversion to ethylene .glycol and the present invention still further provides a process of preparing ethylene glycol by hydrogenating glycolaldehyde prepared by the hydroformylation process described herein above.
Hydrogenation catalysts of use in the conversion of glycolaldehyde to ethylene glycol are well known in the art, for example palladium, platinum or nickel catalysts, often in heterogeneous form. Where glycolaldehyde is prepared in non-aqueous conditions, the selected hydrogenation catalyst may be added directly to the reaction mixture resulting from the preparation of glycolaldehyde with no work-up. procedure, and. gaseous hydrogen introduced. Alternatively, the reaction mixture may be worked-up before the glycolaldehyde is hydrogenated, e.g. by extraction with a suitable solvent such as water or ethylene glycol itself, and the resulting solution then hydrogenated in conventional manner. This approach is particularly convenient when the glycolaldehyde is prepared from aqueous formaldehyde in a reaction medium comprising an aqueous phase as has now been made possible by means of the present invention.
The invention will be further understood from the following illustrative examples.
Ligand Synthesis The following examples, which were performed under an atmosphere of purified argon using standard Schlenk techniques, illustrate a typical preparation of a ligand according to the present invention wherein (1) R2 is an alkyl group (2-phospha-2-icosyl-1,3,5,7-tetramethyl-6,9,10-trioxa-trieyclo[3.3.1.1{3,7}]-decane), and (ii) R2 is of general formula (II) {2-phospha-2-(ethyl-N,N-dimethylamido)-1,3,5,7-tetramethyl-6,9,10-.trioxa-tricyclo [ 3 . 3 .1 .1 ( 3, 7 } ] -decane ) .
(1) Synthesis of 2-phospha - 2-icosyl-1,3,5,7-tetramethyl-6,9,10-trioxa-tricyclo[3.3.1.1{3,7}]-decane.
A borane adduct of 2-phospha-1,3,5,7-tetramethyl-6,9,10-trioxa-tricyclo[3.3.1.1(3,7}]-decane was prepared by adding BH3.THF (70 ml of 1M solution in THF) to a solution of 2-phospha-1,3,5,7-tetramethyl-6,9,10-trioxa-.
tricyclo [ 3 . 3 .1.1 { 3, 7 } ] -decane ( ~0 mmol ) in THF at 0°C .
The reaction mixture was al 1 owed to warm to room temperature and stir for two hours after which time the .
solvent was removed in vacu o to yield the borane adduct.
To a solution of this adduct (16 mmol in THF) a solution of hexyl-lithium ~(6.4 ml, 2.5M in hexane) was added at a temperature of - 70 °C and the reaction mixture allowed to slowly w arm to - 20 °C over a period of 1 hour. After retooling to - 70 °C, a solution of 1-bromo-icosane (16 mmol in T HF) was added. The reaction mixture was then allowed to warm to ambient temperature and stirred for 2 hours bef ore diethylamine (3 ml) was added arid the reaction mixture then refluxed for 12 hours. On completion of the reaction the solvent was removed in vacuo. The product was then isolated by solvent extraction in dichl oromethane-toluene and water, the toluene fractions being evaporated to leave a solid residue that was washed with methanol to yield 2-phospha-2-icosyl-1,3,5,7-tet ramethyl-6,9,10-trioxa-tricyclo[3.3.1.1{3,7}]-decane (96 0).
(ii) Synthesis of 2-phospha-2-(ethyl-N,N-dimethylamido)-1,3,5,7-tetramethyl- 6,9,'10-trioxa-tricyclo[3.3.1.1{3,7}]-decane.
2-Phospha-1,3,5,7-tetramethyl-6,9,10-trioxa-tricyclo[3.3.1.1{3,7}]-decane (40 mmol) and N, N dimethylacrylam.i.de (100 mmol) were introduced into a Schlenk-tube contain ing a mixture of toluene and acetic acid, and heated to a temperature of 115 °C. After 18 hours the reaction mixture was cooled to 80 °C and the solvents evaporated in vacuo. The residue was then .
dissolved in triethylamine and the mixture heated to a temperature of 100 °C for 2.5 hours after which the resulting homogeneou s mixture was cooled to ambient temperature. The product was then isolated by solvent extraction with toluene and water, the toluene fractions being evaporated to yield 2-phospha-2-(ethyl-N,N- .
, dimethylamido) -1, 3, 5, 7-te,tramethyl-6, 9, 10-trioxa-tricyclo [ 3 . 3 . 1. 1 { 3, 7 } ] =decane ( 7 9 0 ) .
Hydroformylation of formaldehyde The following examples were performed in a magnetically stirred 250 ml autoclave. The autoclave was charged with reactan is and solvent after which air was removed and the auto clave pressurised with carbon monoxide and hydroge n, each to a partial pressure of 30bar (3MPa). The oontents of the autoclave were then heated to reaction temperature. Upon completion of the reaction, the contents were cooled and the conversion of formaldehyde, and yield of glycolaldehyde, was determined by means of gas-liquid chromatography using di-ethylene glycol dimethylether as an internal standard. All ligands were prepared using analogous chemistry to that described for ligands (i) and (ii) abov e.
Example 1 ("2-PA"-C20 ligand in non-aqueous conditions) The autoclave was charged with 0.17 mol of formaldehyde, in the form of para-formaldehyde, 62 ml (0.58 mol) of N-methyl-pyrrol idone, 0.25 mmo1 of rhodiumdicarbonylacetonylacet one (Rh(acac)(CO)2), 0.50 mmol of 2-phospha-2-icosyl-1,3,5,7-tetramethyl-6,9,10-trioxa-tricyclo[3.3.1.1{3,7}]-decane, and 9.1 mmol of trimethylbenzoic acid. The contents of the autoclave were then heated to a temperature of 110 °C and maintained at that temperature for 2 hours.
Conversion of formaldehyde was 1000 and the yield of glycolaldehyde, calculated on formaldehyde intake, was 76~. The initial reaction rat a was calculated by measurement of the pressure drop to be 595 mol CO/mol Rh.h.
Example 2 ("2-PA"-CZO ligand in aqueous conditions) The autoclave was charged with 0.17 mol of formaldehyde, in the form of para-formaldehyde, 35 ml (0.22 mol) of dibutyl-acetami de, 25 ml of demineralised 2S water, 0.25 mmol of Rh (acac) (CO) 2, 0 .53 mmol of 2-phospha-2-icosyl-1,3,5,7-tetramethyl-6,9,10-trioxa-tricyclo[3.3.1.1{3,7}]-decane, and 9.1 mmo1 of trimethylbenzoic acid. The contents of the autoclave were heated to a temperature of 110 °C and maintained at that temperature for 5 hours.
Conversion of formaldehyde was 64 o and the yield of glycolaldehyde in the two-phase reaction product, calculated on formaldehyde i make, was 45 0. The initial reaction rate was calculated by measurement of the pressure drop to be 115 mot CO/mol Rh.h Example 3 ("2-PA"-CHzCH2C {0) NMez ligand in non-aqueous conditions) The autoclave was charged with 0.18 mol of formaldehyde, in the form of pares-formaldehyde, 23 ml (0.15 mol) of di-sec-butyl-acetamide, 0.25 mm~l of Rh{a.cac)(CO)2, 0.49 mmol of 2-phospha-2-(ethyl-N,N-dimethylamido)-1,3,5,7-tetramethyl-6,9,10-trioxa-tricyclo[3.3.1.1{3,7}]-decane, and 9.1 mmol of trimethylbenzoic acid. The contents of the autoclave were then heated to a temperature of 100 °C and maintained at that temperature for 3 hours.
Conversion of formaldehyde was 72 o and the yie"ld of glycolaldehyde in the single-phase reaction product, calculated on formaldehyde intake, was 69 0. The initial reaction rate was calculated by measurement of the pressure drop to be 275 mot CO/mol Rh.h.
Example 4 ( "2-PA"-CH~CH2C (0) NMe2 ligand in non-aqueous conditions ) The autoclave was charged with 0.25 mol of formaldehyde, in the form of pares-formaldehyde, 35 ml (0.26 mol) of N,N'-dimethylpropylenurea, 0.10 mmol of Rh(acac)(CO)2, 0.20 mmol of 2-phospha-2-(ethyl-N,N-dimethylamido)-1,3,5,7-tetramethyl-6,9,10-trioxa-tricyclo[3.3.1.1{3,7}]-decane, and 3.1 mmol of trimethylbenzoic acid. The contents of the autoclave were then heated to a temperature of 90 °C and maintained at that temperature~for 5 hours.
Conversion of formaldehyde was 73 o and the yield of glycolaldehyde in the singl e-phase reaction product, calculated on .formaldehyde intake, was 71 %. The initial _ 18 _ reaction rate was calculated by measurement of the pressure drop to be 595 mol CO/mol Rh.h.
Example 5 ("2-PA"-CH2CH2C1g ligand in non-aqueous conditions) The autoclave was charged with 0.25 mol of formaldehyde, in the form of para-formaldehyde, 35 ml (0.26 mol) of N,N'-dimethylpropylenurea, 0.10 mmol of Rh(acac)(CO)2, 0.20 mmol of 2-phospha-2-octyl-1,3,5,7-tetramethyl -6,9,10-trioxa-tricyclo[.3.3.1.1{3,7}]-decane, and 3.1 mmol of trimethylbenzoic acid. The contents of the autoclave were then heated to a temperature of 90 °C
and maintained at that temperature for 5 hours.
Conversion of formaldehyde was 69 o and the yield of glycolaldehyde in the single-phase reaction product, calculated on formaldehyde intake, was 66 0.~ The initial reaction rate was calculated by measurement of the pressure drop to be 518 mol CO/mol Rh.h.
Example 6 ("2-PA"-CH2CH2C(0)NMe2 ligand in aqueous conditions) The autoclave was charged with 0.15 mol of formaldehyde, in the form of a formaline solution (37 0 formaldehyde in water), 37 ml (0.22 mol) of dibutyl-acetamide, 7.5 ml of demineralised water, 0.49 mmol of Rh(acac)(CO)2, 0.96 mmol of 2-phospha-2-(ethyl-N,N-dimethylamido) -1, 3,,5, 7-tetramethyl-6, 9, 10-trioxa-tricyclo[3.3.1.1{3,7}]-decane~, and 9.1 mmol of trimethylbenzoic acid. The contents of the autoclave were heated to a temperature of 90 °C and maintained at that temperature for 5 hours.
Conversion of formaldehyde was 90 o and the yield of glycolaldehyde in the two-phase reaction product, calculated on formaldehyde intake, was 90 0. The initial reaction rate was calculated by measurement of the pressure drop to be 170 mol CO/mo1 Rh.h.
Example 7 ("2-PA"- CH~CH~C(0)NPh~ ligand in aqueous conditions) The autoclave was charged with 0.15. mol of formaldehyde, in the form of a formaline solution (37 formaldehyde), 37 ml (0.~2 mol) of dibutyl-acetamide, 7.5 ml of demineralised water, 0.44 mrnol of Rh(acac)(CO)2, 0.89 mmol of 2-phospha-2-(ethyl-N,N-diphenylamido)-1, 3, 5, 7-tetramethyl-6, 9, 10-trioxa-tricyclo [3 . 3 . 1 . 1 ( 3, 7 } ) -decane, and 9.1 mmol of trimethyl~enzoic acid. The contents of the autoclave were heated to a temperature of 110 °C and maintained at that temp erature for 3 hours.
Conversion of formaldehyde was 100 o and the yield of glycolaldehyde in the two-phase re action product, calculated on formaldehyde intake, was 52 0. The initial reaction rate was calculated by measurement of the pressure drop to be 180 mol CO/mo~ Rh.h.
Comparative Example A
(PPh3 ligand in non-aqueous condit ions) The autoclave was charged with 0.17 mol of formaldehyde, in the form of para- formaldehyde, 37 ml (0.24 mol) of dibutyl-acetamide, 0.25 mmol of Rh(acac)(CO)2, 0.52 mmol of triphe nylphosphine, and 9.3 mmol of trimethylbenzoic acid. The contents of the autoclave were then heated to a temperature of 90 °C and maintained at that temperature fo r 10 hours.
Conversion of formaldehyde was 61 '% and the yield of glycolaldehyde in the single-phase reaction product, calculated on formaldehyde intake, was 40 0. The initial reaction rate was calculated by measurement of the pressure drop to be 75 mol CO/mol Rh.h 2p _ Comparative Example B
(PPh3 ligand in aqueous conditions) The autoclave was char ged with 0.17 mol of formaldehyde, in the form of para-formaldehyde, 37 ml (0.22 mol)~of ~dibutyl-acet amide, 12.5 ml of demineralised water, 0.25 mmol of Rh.(acac) (CO) 2,. 0. 52 mmol of triphenylphosphine, and 9.1 mmol of trimethylbenzoic acid. The contents of the autoclave were heated to a temperature of 90 °C and maintained at that temperature for 10 hours.
Conversion of formaldehyde was 54 % and the yield of glycolaldehyde in the two-phase reaction product, calculated on formaldehyde intake, was 25 %. The reaction rate was calculated by measurement of the pressure drop to be 51 mol CO/mol Rh.h.
Comparative Example C
(9-icosyl-9-phosphabicyclo[3.3.1]nonane ligand in aqueous conditions) The autoclave was charged with 0.17 mol of formaldehyde, in the form of para-formaldehyde, 37 ml (0.19 mol) of N-octyl-pyrrolidone, 25 ml of demineralised water, 0.25 mmol of Rh (acac) (CO) 2, 0. 52 mmol of 9-icosyl-9-phosphabicyclo[3.3.1]nonane, and 9.1 mmol of . trimethylbenzoic acid. The contents of the autoclave were heated to a temperature of 110 °C and maintained at that temperature for 5 hours.
Conversion of formaldehyde was 17 % and the yield of glycolaldehyde in the two-phase reaction product, calculated on formaldehyde intake, Was 6 %.
Comparative Example D
(9-CH2CH2C(0)NMe2-9-phosphabicyclo[3.3.1]nonane liga.nd in aqueous conditions) The autoclave was charged with 0.17.mo1 of formaldehyde, in the form of para-formaldehyde, 37 ml (0.22 mol) of dibutyl-acetamide, 25 m1 of demineralised water, 0.25 mmol of Rh (acac) (CO) 2, 0. 50 mmol of 9-phospha-9-(ethyl-N,N-dimethylamido-bicyclo[3.3.1]nonane, and 9.1 mmol of trimethylbenzoic acid. The contents of the autoclave were then heated to a temperature of 110 °C
and maintained at that temperature for 5~ hours.
Conversion of formaldehyde was 3 o and the yield of glycolaldehyde in the two-phase react ion product, calculated on formaldehyde intake, wa s 0 0.
The above examples demonstrate th a t catalyst compositions according to the present invention display a superior performance to comparative compositions containing a triphenylphosphine ligan d under both~aqueous and non-aqueous conditions (e.g. comp are Examples 1 and 3 with Comparative Example A, and Examples 2 and 4 with Comparative Example B), and to catalysts based on other forms of bicyclic phosphine-containin g ligand (see Comparative Examples C and D). Moreover, from Examples 4 and 5 it.can also be seen that catal~rst compositions of general formula (I) wherein R2 is of general formula -R3-C (0) NR4R5 continue to display a good level of performance even under aqueous~condit ions.
Hvdroaenation to Ethvlene alvcol To demonstrate the ease with which glycolaldehyde prepared according to the present invention may be converted to ethylene glycol, an aqueous phase separated from a hydroformylation reaction pexf ormed under conditions analogous to those of Example 2 ( "2-PA"-CZo ligand in aqueous conditions) was treated with Raney Nickel slurry. The aqueous phase (25 ml, 9.5owt glycolaldehyde) was mixed with Raney Nickel slurry (2m1) and stirred for 15 hours at a temperature 40°C, then.
treated with hydrogen at a pressu re of 50 bar (5Mpa). The conversion from glycolaldehyde to ethylene glycol was 90 0 .
Claims (10)
1. A process of preparing glycolaldehyde which comprises reacting formaldehyde with hydrogen and carbon monoxide in the presence of a catalyst composition which is based on, a) a source of rhodium, and b) a ligand of general formula R1P-R2 (I) wherein R1 is a bivalent radical that together with the phosphorous atom to which it is attached is an optionally substituted 2-phospha-tricyclo [3.3.1.1{3,7}]-decyl group, wherein from 1 to 5 of the carbon atoms has been replaced by a heteroatom, and wherein R2 is a monovalent radical which is an optionally substituted hydrocarbyl group having from 1 to 40 carbon atoms.
2. A process as claimed in claim 1, wherein the catalyst composition further comprises c) a source of anions.
3. A process as claimed in claim 1 or claim 2, wherein bivalent radical R1 together with the phosphorous atom to which it is attached is a 2-phospha-1,3,5,7-tetralkyl-6,9,10-trioxa-tricyclo [3.3.1.1{3,7}]-decyl group.
4. A process as claimed in any one of claims 1 to 3, wherein monovalent radical R2 is an alkyl group having from 4 to 34 carbon atoms.
5. A process as claimed in any one of claims 1 to claim 3, wherein monovalent radical R2 is of general formula -R3-C(O)NR4R5 (II) wherein R3 is an alkylene group and R4 and R5 independently represent an alkyl, cycloalkyl, aryl or alkaryl group, or R4 and R5 together represent a bivalent bridging group.
6. A process as claimed in any one of claims 1 to 5, wherein the source of formaldehyde is aqueous formaldehyde and the reaction is performed in a reaction medium comprising an aqueous phase and an organic phase, wherein the organic phase and aqueous phase are immiscible at 22 °C.
7. A process as claimed in claim 6, wherein the organic phase comprises a water-immiscible amide solvent.
8. A catalyst composition obtainable by combining a) a source of rhodium, b) a ligand of general formula R1P-R2 (I) wherein R1 is a bivalent radical that together with the phosphorous atom to which it is attached is an optionally substituted 2-phospha-tricyclo [3.3.1.11{3,7}]-decyl group, wherein from 1 to 5 of the carbon atoms has been replaced by a heteroatom, and wherein R2 is a monovalent radical which is an optionally substituted alkyl group having from 10 to 40 carbon atoms, or monovalent radical R2 is of general formula -R3-C(O)NR4R5 (II) wherein R3 is an alkylene group and R4 and R5 independently represent an alkyl, cycloalkyl, aryl or alkaryl group, or R4 and R5 together represent a bivalent bridging group, and optionally c) a source of anions.
9. A catalyst composition as claimed in claim 8, wherein, in the ligand b), R2 is of the general formula II.
10. A process of preparing ethylene glycol which comprises preparing glycolaldehyde by a process as claimed in any one of claims 1 to 7, and then hydrogenating said glycolaldehyde.
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US3026327A (en) * | 1960-07-06 | 1962-03-20 | American Cyanamid Co | Substituted 1, 3, 5, 7-tetraalkyl-2, 6, 9-trioxa-10-phosphatricyclo [3.3.1.1.3,7] decanes |
US4414421A (en) * | 1981-08-03 | 1983-11-08 | Shell Oil Company | Process for the preparation of glycol aldehyde |
US4608444A (en) * | 1984-04-05 | 1986-08-26 | The Halcon Sd Group, Inc. | Process and accompanying catalysts for the hydroformylation of formaldehyde to glycol-aldehyde |
US4847423A (en) * | 1988-03-03 | 1989-07-11 | Hoechst Celanese Corporation | Hydroformylation of aqueous formaldehyde using a rhodium-tricyclohexylphosphine catalyst system |
US5567856A (en) * | 1995-05-30 | 1996-10-22 | Hoechst Celanese Corporation | Synthesis of and hydroformylation with fluoro-substituted bidentate phosphine ligands |
DE10023468A1 (en) * | 2000-05-12 | 2001-11-15 | Basf Ag | Novel ligand-metal complex, useful for hydroformylation of ethylenically unsaturated compounds, comprises ruthenium, rhodium, palladium and platinum and a monophosphine, monophosphinite or monophosphinamidite ligand |
-
2004
- 2004-12-15 AU AU2004298446A patent/AU2004298446B2/en not_active Ceased
- 2004-12-15 MX MXPA06006705A patent/MXPA06006705A/en active IP Right Grant
- 2004-12-15 KR KR1020067012776A patent/KR20060117345A/en not_active Application Discontinuation
- 2004-12-15 EP EP04804845A patent/EP1697291A1/en not_active Withdrawn
- 2004-12-15 RU RU2006125408/04A patent/RU2371429C2/en not_active IP Right Cessation
- 2004-12-15 JP JP2006544436A patent/JP4474419B2/en active Active
- 2004-12-15 BR BRPI0417643-0A patent/BRPI0417643A/en not_active IP Right Cessation
- 2004-12-15 CA CA002549456A patent/CA2549456A1/en not_active Abandoned
- 2004-12-15 US US10/583,109 patent/US7449607B2/en not_active Expired - Fee Related
- 2004-12-15 WO PCT/EP2004/053492 patent/WO2005058788A1/en active Application Filing
- 2004-12-15 CN CNB2004800376940A patent/CN100434412C/en active Active
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2008
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AU2004298446B2 (en) | 2008-07-31 |
EP1697291A1 (en) | 2006-09-06 |
CN1894188A (en) | 2007-01-10 |
BRPI0417643A (en) | 2007-03-27 |
US20090012333A1 (en) | 2009-01-08 |
CN100434412C (en) | 2008-11-19 |
JP4474419B2 (en) | 2010-06-02 |
MXPA06006705A (en) | 2006-08-23 |
US7449607B2 (en) | 2008-11-11 |
JP2007516976A (en) | 2007-06-28 |
RU2371429C2 (en) | 2009-10-27 |
KR20060117345A (en) | 2006-11-16 |
AU2004298446A1 (en) | 2005-06-30 |
US7511178B2 (en) | 2009-03-31 |
RU2006125408A (en) | 2008-01-27 |
WO2005058788A1 (en) | 2005-06-30 |
US20070249871A1 (en) | 2007-10-25 |
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