CA2543029A1 - Inhibition par l'arn interference de l'expression des genes gpra et aaa1 utilisant un acide nucleique court - Google Patents
Inhibition par l'arn interference de l'expression des genes gpra et aaa1 utilisant un acide nucleique court Download PDFInfo
- Publication number
- CA2543029A1 CA2543029A1 CA002543029A CA2543029A CA2543029A1 CA 2543029 A1 CA2543029 A1 CA 2543029A1 CA 002543029 A CA002543029 A CA 002543029A CA 2543029 A CA2543029 A CA 2543029A CA 2543029 A1 CA2543029 A1 CA 2543029A1
- Authority
- CA
- Canada
- Prior art keywords
- sina
- nucleotides
- sina molecule
- molecule
- gpra
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N2310/31—Chemical structure of the backbone
- C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
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- C12N2310/321—2'-O-R Modification
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- C12N2310/33—Chemical structure of the base
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- C12N2310/53—Physical structure partially self-complementary or closed
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Applications Claiming Priority (21)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/693,059 | 2003-10-23 | ||
US10/693,059 US20080039414A1 (en) | 2002-02-20 | 2003-10-23 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US10/720,448 | 2003-11-24 | ||
US10/720,448 US8273866B2 (en) | 2002-02-20 | 2003-11-24 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA) |
US10/727,780 US20050233329A1 (en) | 2002-02-20 | 2003-12-03 | Inhibition of gene expression using duplex forming oligonucleotides |
US10/727,780 | 2003-12-03 | ||
US10/757,803 US20050020525A1 (en) | 2002-02-20 | 2004-01-14 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US10/757,803 | 2004-01-14 | ||
US54348004P | 2004-02-10 | 2004-02-10 | |
US60/543,480 | 2004-02-10 | ||
US10/780,447 | 2004-02-13 | ||
US10/780,447 US7491805B2 (en) | 2001-05-18 | 2004-02-13 | Conjugates and compositions for cellular delivery |
US10/826,966 US20050032733A1 (en) | 2001-05-18 | 2004-04-16 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA) |
US10/826,966 | 2004-04-16 | ||
PCT/US2004/013456 WO2005041859A2 (fr) | 2003-04-30 | 2004-04-30 | Conjugues et compositions |
USPCT/US04/13456 | 2004-04-30 | ||
US57008604P | 2004-05-11 | 2004-05-11 | |
US60/570,086 | 2004-05-11 | ||
PCT/US2004/016390 WO2005019453A2 (fr) | 2001-05-18 | 2004-05-24 | Interference arn a mediation assuree par l'inhibition de genes au moyen de petit acide nucleique interferent (ansi) modifie chimiquement |
USPCT/US04/16390 | 2004-05-24 | ||
PCT/US2004/027231 WO2005045038A2 (fr) | 2003-10-23 | 2004-08-20 | Inhibition par l'arn interference de l'expression des genes gpra et aaa1 utilisant un acide nucleique court |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2543029A1 true CA2543029A1 (fr) | 2005-05-19 |
Family
ID=56290594
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002543029A Abandoned CA2543029A1 (fr) | 2003-10-23 | 2004-08-20 | Inhibition par l'arn interference de l'expression des genes gpra et aaa1 utilisant un acide nucleique court |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1694838A2 (fr) |
JP (1) | JP2007527709A (fr) |
CA (1) | CA2543029A1 (fr) |
WO (1) | WO2005045038A2 (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6574383B2 (ja) | 2012-12-05 | 2019-09-11 | アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. | PCSK9iRNA組成物及びその使用方法 |
CN114469984A (zh) | 2015-08-25 | 2022-05-13 | 阿尔尼拉姆医药品有限公司 | 用于治疗前蛋白转化酶枯草杆菌蛋白酶kexin(pcsk9)基因相关障碍的方法和组合物 |
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WO2003070918A2 (fr) * | 2002-02-20 | 2003-08-28 | Ribozyme Pharmaceuticals, Incorporated | Inhibition mediee par interference arn d'une expression genique faisant appel a des acides nucleiques interferants courts chimiquement modifies (sina) |
CZ302719B6 (cs) * | 2000-12-01 | 2011-09-21 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Izolovaná molekula dvouretezcové RNA, zpusob její výroby a její použití |
WO2003072590A1 (fr) * | 2002-02-20 | 2003-09-04 | Sirna Therapeutics, Inc. | Inhibition a mediation par interference d'arn de genes de map kinase |
JP4210737B2 (ja) * | 2001-07-12 | 2009-01-21 | ユニバーシティー オブ マサチューセッツ | 遺伝子サイレンシングを仲介する低分子干渉リボ核酸のインビボにおける製造方法 |
EP1572739B1 (fr) * | 2002-12-20 | 2008-07-16 | Geneos OY | Locus de susceptibilite a l'asthme |
-
2004
- 2004-08-20 EP EP04781836A patent/EP1694838A2/fr not_active Withdrawn
- 2004-08-20 CA CA002543029A patent/CA2543029A1/fr not_active Abandoned
- 2004-08-20 WO PCT/US2004/027231 patent/WO2005045038A2/fr active Application Filing
- 2004-08-20 JP JP2006536611A patent/JP2007527709A/ja active Pending
Also Published As
Publication number | Publication date |
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EP1694838A2 (fr) | 2006-08-30 |
JP2007527709A (ja) | 2007-10-04 |
WO2005045038A8 (fr) | 2005-07-14 |
WO2005045038A3 (fr) | 2006-03-02 |
WO2005045038A2 (fr) | 2005-05-19 |
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