CA2508832A1 - Device and patch for controlled release of vanillin - Google Patents

Device and patch for controlled release of vanillin Download PDF

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Publication number
CA2508832A1
CA2508832A1 CA002508832A CA2508832A CA2508832A1 CA 2508832 A1 CA2508832 A1 CA 2508832A1 CA 002508832 A CA002508832 A CA 002508832A CA 2508832 A CA2508832 A CA 2508832A CA 2508832 A1 CA2508832 A1 CA 2508832A1
Authority
CA
Canada
Prior art keywords
vanillin
gaseous
layer
mixtures
container
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002508832A
Other languages
French (fr)
Other versions
CA2508832C (en
Inventor
Norbert Hoenzelaer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2508832A1 publication Critical patent/CA2508832A1/en
Application granted granted Critical
Publication of CA2508832C publication Critical patent/CA2508832C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy

Abstract

The invention relates to devices for continuous release of vanillin or at least one of its derivatives or mixtures thereof, comprising a layer impermeable to gaseous vanillin or a gaseous vanillin derivative or gaseous mixtures thereof; a layer permeable to gaseous vanillin or to the at least o ne gaseous vanillin derivative or the gaseous mixtures thereof and a compositio n containing vanillin or the at least one vanillin derivative or the mixtures thereof, which is localized between said two layers. The invention also relates to a method for the production of said devices, to the devices obtained according to said method, to the utilization of the above-mentioned devices for stimulating the release of serotonin in the central nervous syst em and to the utilization of said devices in a diet plan.

Claims (14)

1. A device for continuously releasing vanillin or at least vanillin derivatives or mixtures thereof, comprising - a layer impermeable to gaseous vanillin or to gaseous vanillin derivatives or to gaseous mixtures thereof, wherein this layer having the form of a container (1), - a layer permeable to gaseous vanillin or to gaseous vanillin derivatives or to gaseous mixtures thereof, as top layer (2), - the top layer (2) adhering to the container (1) with sufficient strength that a force F1 of at least 0.5 N is required to separate the top layer (2) from the container (1), - and the side of the container (1) opposite the top layer (2) being provided, on its side facing away from the top layer (2), with an adhesive, -a first, protective liner layer (3), which attaches adhesively to the side of the container (1) that has been provided with the adhesive, and which can be separated from the container (1) by peeling by hand, the adhesive remaining on the container (1), a second protective liner layer (4), made of a material which is impermeable to gaseous vanillin or to gaseous vanillin derivatives or to gaseous mixtures thereof, which attaches adhesively to the side of the top layer (2) that is facing away from the container (1), and can be separated from the top layer (2) by the action of a force F2, which is smaller than the force F1, and - a composition (Z) in the container (1), said composition being free from active insecticidal substances and comprising vanillin or vanillin derivatives or mixtures thereof.
2. A device as claimed in claim 1, wherein - the container (2) have the form of a trough whose open side possesses a flat, outwardly curved edge, and wherein - the top layer (2) is attached to the flat, outwardly curved edge of the trough.
3. A device as claimed in claim 2, wherein the though is transparent.
4. A device for continuously releasing vanillin or vanillin derivatives or mixtures thereof, comprising - a layer impermeable to gaseous vanillin or to gaseous vanillin derivatives or to gaseous mixtures thereof, which has the form of a container (5), - a layer permeable to gaseous vanillin or to gaseous vanillin derivatives or to gaseous mixtures thereof, as top layer (6), - the top layer (6) adhering to the container (5) with sufficient strength that a force F1 of at least 0.5 N is required to separate the top layer (6) from the container (5), - and the top layer (6) being provided on the side facing away from the container (5) with an adhesive, - a protective liner layer (7), made of a material which is impermeable to gaseous vanillin or to gaseous vanillin derivatives or to gaseous mixtures thereof, which attaches adhesively to the side of the top layer (6) provided with the adhesive and can be separated from the top layer (6) by the action of a force F2, which is smaller than the force F1, the adhesive remaining on the top layer (6), - a composition (Z) in the container (5), said composition being free from active insecticidal substances and comprising vanillin or vanillin derivatives or mixtures thereof.
5. A device in the form of a patch for continuously releasing vanillin or vanillin derivatives or mixtures thereof, comprising - a layer (8) impermeable to gaseous vanillin or to gaseous vanillin derivatives or to gaseous mixtures thereof, - an overlying layer (9), permeable to gaseous vanillin or to gaseous vanillin derivatives or to gaseous mixtures thereof, and a composition (Z) located between both layers, said composition being free from active insecticidal substances and comprising vanillin or vanillin derivatives or mixtures thereof, - layer (8) impermeable to gaseous vanillin or to gaseous vanillin derivatives or to gaseous mixtures thereof being provided on its side facing away from the permeable layer (9) with an adhesive, - afirst, protective liner layer (10), which attaches adhesively to the side of the impermeable layer (8) that has been provided with the adhesive, and which can be separated from this film by peeling by hand, the adhesive remaining on the impermeable layer (8), - a second protective liner layer (11), made of a material which is impermeable to gaseous vanillin or to gaseous vanillin derivatives or to gaseous mixtures thereof, which attaches adhesively to the permeable layer (9) on its side that is facing away from the impermeable layer (8), and can be separated by peeling by hand from the permeable layer (9).
6. A device in the form of a patch for continuously releasing vanillin or vanillin derivatives or mixtures thereof, comprising - the layer (12) impermeable to gaseous vanillin or to gaseous ethyl vanillin or to gaseous mixtures thereof, - an underlying layer (13), permeable to gaseous vanillin or to gaseous vanillin derivatives or to gaseous mixtures thereof, and the composition (Z) located between both layers, said composition being free from active insecticidal substances and comprising vanillin or vanillin derivatives or mixtures thereof.

- the layer (13) permeable to gaseous vanillin or to gaseous vanillin derivatives or to gaseous mixtures thereof being provided on its side facing away from the impermeable layer (12) with an adhesive, - a protective liner layer (14), which attaches adhesively to the side of the permeable layer (13) that has been provided with the adhesive, and can be separated from this layer by peeling by hand, the adhesive remaining on the permeable layer (13).
7. The device as claimed in claim 4 or 5, wherein the composition has a dynamic viscosity in a range from 10 2 to 10 5 mPa~s at 20°C in accordance with DIN 53211.
8. The device as claimed in any one of the preceding claims, wherein said permeable layer comprises a film comprising polyethylene, polyamide, ethylene-vinyl acetate copolymer or mixtures thereof.
9. The device as claimed in any one of the preceding claims, wherein the composition is based on (.alpha.l) vanillin or vanillin derivatives or mixtures thereof in an amount in a range from 0.1% to 100% by weight;
(.alpha.2) a vehicle in an amount in a range from 0% to 99% by weight; and (.alpha.3) excipients in an amount in a range from 0% to 50% by weight;
the sum of components (.alpha.1) to (.alpha.3) being 100% by weight.
10. A process for producing a device for controlledly releasing vanillin or vanillin derivatives or mixtures thereof as claimed in any one of the claims 1 to 4, wherein - introducing the composition into the container, - and subsequently sealing the container with the impermeable layer in such a way that separation of the impermeable layer from the container requires a force of at least 0.5 N.
11. A process for producing a device for controlledly releasing vanillin or vanillin derivatives or mixtures thereof as claimed in any one of the claims 5 to 7, wherein the composition being located between the permeable and the impermeable layers.
12. A device obtained according to a method as claimed in claim 10 or 11.
13. Utilization of a device as claimed in any one of claims 1 to 9, to stimulate the release of serotonin in the central nervous system.
14. Utilization of a device as claimed in any one of claims 1 to 9, in a diet plan.
CA2508832A 2001-12-07 2002-12-06 Device and patch for controlled release of vanillin Expired - Fee Related CA2508832C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10160110.7 2001-12-07
DE10160110A DE10160110A1 (en) 2001-12-07 2001-12-07 Device and patch for the controlled release of vanillin
PCT/EP2002/013820 WO2003047557A2 (en) 2001-12-07 2002-12-06 Device and patch for controlling the release of vanillin

Publications (2)

Publication Number Publication Date
CA2508832A1 true CA2508832A1 (en) 2003-06-12
CA2508832C CA2508832C (en) 2011-08-30

Family

ID=7708343

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2508832A Expired - Fee Related CA2508832C (en) 2001-12-07 2002-12-06 Device and patch for controlled release of vanillin

Country Status (6)

Country Link
EP (1) EP1523305B1 (en)
AT (1) ATE522206T1 (en)
AU (1) AU2002358625A1 (en)
CA (1) CA2508832C (en)
DE (1) DE10160110A1 (en)
WO (1) WO2003047557A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9522217B2 (en) 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
EP2946666B1 (en) 2004-04-30 2017-11-15 OrbusNeich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods of using same
DE102005033543A1 (en) * 2005-07-14 2007-01-18 Grünenthal GmbH A fragrance-containing transdermal therapeutic system

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6038369B2 (en) * 1981-09-28 1985-08-31 日東電工株式会社 Anhydrous patch preparation
DE3216609A1 (en) * 1982-05-04 1983-11-10 Dietic Dr. Widmann Pharma + Diät GmbH, 6930 Eberbach Plaster inhalant
US4849224A (en) * 1987-11-12 1989-07-18 Theratech Inc. Device for administering an active agent to the skin or mucosa
US5455043A (en) * 1990-06-13 1995-10-03 Fischel-Ghodsian; Fariba Device for controlled release of vaporous medications through nasal route
DE4433191A1 (en) * 1994-09-17 1996-03-21 Lohmann Therapie Syst Lts Self-adhesive plaster for delivering active substance to the environment of a wearer
EP0844872B1 (en) * 1995-07-14 2000-12-20 The Aromacology Patch Company Limited Use of aromas and flavours to induce or change eating patterns
GB9720479D0 (en) * 1996-10-23 1997-11-26 Le Gall Madeleine Dressing
DE19712359A1 (en) * 1997-03-25 1998-10-01 Labtec Gmbh System for long-term administration of substance volatile at body temperature without irritating skin
KR20010025288A (en) * 2000-12-06 2001-04-06 정해영 Protocatechuic aldehyde as a tyrosinase inhibitor and herb extract containing the compound

Also Published As

Publication number Publication date
DE10160110A1 (en) 2003-06-26
ATE522206T1 (en) 2011-09-15
AU2002358625A1 (en) 2003-06-17
CA2508832C (en) 2011-08-30
EP1523305B1 (en) 2011-08-31
WO2003047557A2 (en) 2003-06-12
WO2003047557A3 (en) 2003-09-18
EP1523305A2 (en) 2005-04-20

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MKLA Lapsed

Effective date: 20121206