CA2483916A1 - Methods and formulations for enhancing the absorption and gastro-intestinal bioavailability of hydrophobic drugs - Google Patents

Methods and formulations for enhancing the absorption and gastro-intestinal bioavailability of hydrophobic drugs Download PDF

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Publication number
CA2483916A1
CA2483916A1 CA002483916A CA2483916A CA2483916A1 CA 2483916 A1 CA2483916 A1 CA 2483916A1 CA 002483916 A CA002483916 A CA 002483916A CA 2483916 A CA2483916 A CA 2483916A CA 2483916 A1 CA2483916 A1 CA 2483916A1
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CA
Canada
Prior art keywords
gastro
formulations
enhancing
absorption
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002483916A
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French (fr)
Other versions
CA2483916C (en
Inventor
Curtis A. Spilburg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zomanex LLC
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Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2483916A1 publication Critical patent/CA2483916A1/en
Application granted granted Critical
Publication of CA2483916C publication Critical patent/CA2483916C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes

Abstract

A hydrophobic drug delivery system that includes a plant derived sterol (stanol), lecithin or a sterol (stanol) derived ester, and an active, hydrophobic drug, all dissolved and then dried to form a liposome delivery system.
CA002483916A 2002-05-07 2003-03-31 Methods and formulations for enhancing the absorption and gastro-intestinal bioavailability of hydrophobic drugs Expired - Lifetime CA2483916C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/140,620 2002-05-07
US10/140,620 US20030212046A1 (en) 2002-05-07 2002-05-07 Methods and formulations for enhancing the absorption and gastro-intestinal bioavailability of hydrophobic drugs
PCT/US2003/010146 WO2003094891A1 (en) 2002-05-07 2003-03-31 Methods and formulations for enhancing the absorption and gastro-intestinal bioavailability of hydrophobic drugs

Publications (2)

Publication Number Publication Date
CA2483916A1 true CA2483916A1 (en) 2003-11-20
CA2483916C CA2483916C (en) 2009-10-13

Family

ID=29399473

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002483916A Expired - Lifetime CA2483916C (en) 2002-05-07 2003-03-31 Methods and formulations for enhancing the absorption and gastro-intestinal bioavailability of hydrophobic drugs

Country Status (11)

Country Link
US (2) US20030212046A1 (en)
EP (1) EP1501480B1 (en)
JP (1) JP4630658B2 (en)
AT (1) ATE468842T1 (en)
AU (1) AU2003220643B8 (en)
BR (1) BRPI0309851B1 (en)
CA (1) CA2483916C (en)
DE (1) DE60332721D1 (en)
ES (1) ES2342272T3 (en)
MX (1) MXPA04010923A (en)
WO (1) WO2003094891A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4889262B2 (en) * 2005-08-19 2012-03-07 理研ビタミン株式会社 Fat-soluble drug composition
JP4969989B2 (en) * 2006-10-19 2012-07-04 キユーピー株式会社 Phospholipid composition, food composition containing the same, pharmaceutical composition, and method for producing the same
US20080124387A1 (en) * 2006-11-27 2008-05-29 Kapac, Llc Methods and formulations for enhancing the absorption and decreasing the absorption variability of orally administered drugs, vitamins and nutrients
EP2200613B1 (en) 2007-09-21 2018-09-05 The Johns Hopkins University Phenazine derivatives and uses thereof
US20090088393A1 (en) * 2007-09-28 2009-04-02 Zomanex, Llc Methods and formulations for converting intravenous and injectable drugs into oral dosage forms
JP5221114B2 (en) * 2007-11-30 2013-06-26 キユーピー株式会社 Soft capsule
US9445975B2 (en) 2008-10-03 2016-09-20 Access Business Group International, Llc Composition and method for preparing stable unilamellar liposomal suspension
EP2682111A1 (en) 2009-12-31 2014-01-08 Differential Drug Development Associates LLC Modulation of solubility, stability, absorption, metabolism, and pharmacokinetic profile of lipophilic drugs by sterols
DE102010013064A1 (en) * 2010-03-26 2011-12-15 Gabriele Blume Novel carrier system for the transport of active ingredients into the skin
WO2014143127A1 (en) 2013-03-15 2014-09-18 Differential Drug Development Associates Llc Emulsion formulations
EP3206663B1 (en) 2014-10-17 2018-09-19 Raisio Nutrition Ltd. Cholesterol lowering capsules
US20170106020A1 (en) * 2015-10-19 2017-04-20 Stanley James Harless Anesthetic/analgesic composition
JP6211220B1 (en) * 2017-01-26 2017-10-11 アピ株式会社 Anthocyanin-containing composition for capsule and capsule

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GB1575343A (en) * 1977-05-10 1980-09-17 Ici Ltd Method for preparing liposome compositions containing biologically active compounds
CH621479A5 (en) * 1977-08-05 1981-02-13 Battelle Memorial Institute
FR2416008A1 (en) * 1978-02-02 1979-08-31 Oreal LIPOSOME LYOPHILISATES
US4348384A (en) * 1980-10-17 1982-09-07 Dainippon Pharmaceutical Co., Ltd. Pharmaceutical composition for oral administration containing coagulation factor VIII or IX
FR2521565B1 (en) * 1982-02-17 1985-07-05 Dior Sa Parfums Christian PULVERULENT MIXTURE OF LIPID COMPONENTS AND HYDROPHOBIC CONSTITUENTS, METHOD FOR PREPARING SAME, HYDRATED LIPID LAMELLAR PHASES AND MANUFACTURING METHOD, PHARMACEUTICAL OR COSMETIC COMPOSITIONS COMPRISING HYDRATED LAMID PHASES
FR2534487B1 (en) * 1982-10-15 1988-06-10 Dior Christian Parfums METHOD FOR THE HOMOGENEIZATION OF HYDRATED LIPIDAL LAMELLAR PHASE DISPERSIONS, AND SUSPENSIONS OBTAINED THEREBY
US4744989A (en) * 1984-02-08 1988-05-17 E. R. Squibb & Sons, Inc. Method of preparing liposomes and products produced thereby
US4830858A (en) * 1985-02-11 1989-05-16 E. R. Squibb & Sons, Inc. Spray-drying method for preparing liposomes and products produced thereby
IT1203515B (en) * 1987-02-26 1989-02-15 Indena Spa SAPONINE COMPLEXES WITH PHOSPHOLIPIDS AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM
US5811119A (en) * 1987-05-19 1998-09-22 Board Of Regents, The University Of Texas Formulation and use of carotenoids in treatment of cancer
US4963362A (en) * 1987-08-07 1990-10-16 Regents Of The University Of Minnesota Freeze-dried liposome mixture containing cyclosporin
US5202126A (en) * 1987-08-20 1993-04-13 Parfums Christian Dior Composition containing pregnenolone or a pregnenolone ester incorporated in liposomes, and a method for regenerating, or revitalizing the skin therewith
US5290562A (en) * 1987-11-27 1994-03-01 L V M H Recherche Compositions and methods employing liposomes including tyrosine or a tyrosine derivative
FR2623716B1 (en) * 1987-11-27 1991-04-05 Lvmh Rech COMPOSITION BASED ON HYDRATED LIPID LAMID PHASES OR LIPOSOMES CONTAINING TYROSINE OR A TYROSINE DERIVATIVE AND COSMETIC OR PHARMACEUTICAL COMPOSITION, ESPECIALLY DERMATOLOGICAL, WITH PIGMENTANT ACTIVITY, INCORPORATING IT
WO1989008499A1 (en) * 1988-03-17 1989-09-21 Nippon Fine Chemical Co., Ltd. Liposome
US5015483A (en) * 1989-02-09 1991-05-14 Nabisco Brands, Inc. Liposome composition for the stabilization of oxidizable substances
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JPH0491026A (en) * 1990-08-06 1992-03-24 Green Cross Corp:The Fat emulsion containing vegetable sterol
US5244887A (en) * 1992-02-14 1993-09-14 Straub Carl D Stanols to reduce cholesterol absorption from foods and methods of preparation and use thereof
WO1994028876A1 (en) * 1993-06-07 1994-12-22 Advanced Therapies, Inc. Liposome powders
US5853755A (en) * 1993-07-28 1998-12-29 Pharmaderm Laboratories Ltd. Biphasic multilamellar lipid vesicles
ES2115343T3 (en) * 1993-11-05 1998-06-16 Amgen Inc METHOD OF PREPARATION OF LIPOSOMES AND ENCAPSULATION OF MATERIAL.
US5766627A (en) * 1993-11-16 1998-06-16 Depotech Multivescular liposomes with controlled release of encapsulated biologically active substances
JP3299054B2 (en) * 1994-10-19 2002-07-08 花王株式会社 Skin cosmetics
US5945409A (en) * 1995-03-10 1999-08-31 Wilson T. Crandall Topical moisturizing composition and method
CH689139A5 (en) * 1995-04-03 1998-10-30 Cerbios Pharma Sa Process for the preparation of a liposomal, in water dispersable, orally administrable, solid, dry therapeutic formulation.
EP0927025A4 (en) * 1996-09-18 2001-07-25 Dragoco Inc Liposome encapsulated active agent dry powder composition
US6312703B1 (en) * 1998-02-06 2001-11-06 Lecigel, Llc Compressed lecithin preparations
US6110502A (en) * 1998-02-19 2000-08-29 Mcneil-Ppc, Inc. Method for producing water dispersible sterol formulations
US5965518A (en) * 1998-02-23 1999-10-12 Nakatsu; Tetsuo Fragrance compositions having antimicrobial activity
US6063776A (en) * 1998-05-26 2000-05-16 Washington University Sitostanol formulation with emulsifier to reduce cholesterol absorption and method for preparing and use of same
US5932562A (en) * 1998-05-26 1999-08-03 Washington University Sitostanol formulation to reduce cholesterol absorption and method for preparing and use of same
US6242001B1 (en) * 1998-11-30 2001-06-05 Mcneil-Ppc, Inc. Method for producing dispersible sterol and stanol compounds

Also Published As

Publication number Publication date
AU2003220643B2 (en) 2006-11-23
DE60332721D1 (en) 2010-07-08
ES2342272T3 (en) 2010-07-05
US20030212046A1 (en) 2003-11-13
AU2003220643A1 (en) 2003-11-11
ATE468842T1 (en) 2010-06-15
MXPA04010923A (en) 2005-07-14
BR0309851A (en) 2005-03-15
CA2483916C (en) 2009-10-13
BRPI0309851B1 (en) 2017-02-21
US20050244488A1 (en) 2005-11-03
EP1501480A1 (en) 2005-02-02
WO2003094891A1 (en) 2003-11-20
JP4630658B2 (en) 2011-02-09
AU2003220643B8 (en) 2009-06-18
JP2005526119A (en) 2005-09-02
EP1501480B1 (en) 2010-05-26

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Effective date: 20230331