CA2473422A1 - Preparation of 5-chlorimidazoles - Google Patents

Preparation of 5-chlorimidazoles

Info

Publication number
CA2473422A1
CA2473422A1 CA002473422A CA2473422A CA2473422A1 CA 2473422 A1 CA2473422 A1 CA 2473422A1 CA 002473422 A CA002473422 A CA 002473422A CA 2473422 A CA2473422 A CA 2473422A CA 2473422 A1 CA2473422 A1 CA 2473422A1
Authority
CA
Canada
Prior art keywords
preparation
substituted
optionally
general formula
chlorimidazoles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002473422A
Other languages
French (fr)
Other versions
CA2473422C (en
Inventor
Gareth Griffiths
Rene Imwinkelried
Jacques Gosteli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Original Assignee
Lonza Ltd.
Gareth Griffiths
Rene Imwinkelried
Jacques Gosteli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Ltd., Gareth Griffiths, Rene Imwinkelried, Jacques Gosteli filed Critical Lonza Ltd.
Publication of CA2473422A1 publication Critical patent/CA2473422A1/en
Application granted granted Critical
Publication of CA2473422C publication Critical patent/CA2473422C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/68—Halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Steroid Compounds (AREA)

Abstract

The optionally 2-substituted 5-chloroimidazoles of the general formula <IMAGE> are novel intermediates for the preparation of antihypertensive pharmaceuticals (vasodepressants) or of herbicidally active compounds. There are described a process for the preparation of these intermediates and a novel process for the further reaction of optionally 2-substituted 5-chloroimidazoles of the general formula I in which R<1> is hydrogen to give the optionally 2-substituted 5-chloroimidazole-4-carbaldehydes of the general formula <IMAGE>
CA002473422A 1993-03-12 1994-03-14 Preparation of 5-chlorimidazoles Expired - Fee Related CA2473422C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CHGES.748/93 1993-03-12
CH74893 1993-03-12
CA002117209A CA2117209C (en) 1993-03-12 1994-03-14 2-substituted-5-chlorimidazoles

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002117209A Division CA2117209C (en) 1993-03-12 1994-03-14 2-substituted-5-chlorimidazoles

Publications (2)

Publication Number Publication Date
CA2473422A1 true CA2473422A1 (en) 1994-09-13
CA2473422C CA2473422C (en) 2007-05-22

Family

ID=4194282

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002117209A Expired - Fee Related CA2117209C (en) 1993-03-12 1994-03-14 2-substituted-5-chlorimidazoles
CA002473422A Expired - Fee Related CA2473422C (en) 1993-03-12 1994-03-14 Preparation of 5-chlorimidazoles

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA002117209A Expired - Fee Related CA2117209C (en) 1993-03-12 1994-03-14 2-substituted-5-chlorimidazoles

Country Status (9)

Country Link
EP (2) EP0614890B1 (en)
JP (1) JP3716434B2 (en)
KR (1) KR100362353B1 (en)
AT (2) ATE157655T1 (en)
CA (2) CA2117209C (en)
DE (2) DE59403903D1 (en)
DK (2) DK0614890T3 (en)
ES (2) ES2108894T3 (en)
HU (2) HU213387B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2175420C (en) * 1995-05-17 2007-04-10 Gareth Griffiths Process for the preparation of optionally 2-substituted 5-chloroimidazole-4-carbaldehydes
JP4103149B2 (en) * 1996-01-05 2008-06-18 ロンザ リミテッド Process for producing 2-substituted 5-chloroimidazole-4-carbaldehyde
KR101035559B1 (en) * 2009-06-02 2011-05-19 한국화학연구원 Pharmaceutical composition for the prevention or treatment of osteoporosis or obesity comprising a chloroimidazole derivative or a pharmaceutically acceptable salt thereof as an active ingredient

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3409606A (en) * 1965-12-30 1968-11-05 American Cyanamid Co Halogenated chloroimidazole compounds
IL53783A (en) * 1977-02-03 1982-08-31 American Cyanamid Co Imidazo(1,5-d)-as-triazine-4 (3h)-(thi)one derivatives,their preparation and pharmaceutical compositions containing them
JPS5671074A (en) * 1979-11-12 1981-06-13 Takeda Chem Ind Ltd 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative
DE3145927A1 (en) * 1981-11-20 1983-06-01 Basf Ag, 6700 Ludwigshafen 4(5)-Methyl-5(4)-chloroimidazole and process for its preparation
DE3330192A1 (en) * 1983-08-20 1985-03-07 Basf Ag, 6700 Ludwigshafen 4-ALKYLIMIDAZOLE DERIVATIVES, THEIR PRODUCTION AND USE
JPS62238383A (en) * 1986-04-07 1987-10-19 Chiyoda Kagaku Kenkyusho:Kk Anticorrosive
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
JPH02262562A (en) * 1988-10-20 1990-10-25 Ishihara Sangyo Kaisha Ltd Imidazole compound
PT95899A (en) * 1989-11-17 1991-09-13 Glaxo Group Ltd PROCESS FOR THE PREPARATION OF INDOLE DERIVATIVES
JPH0426678A (en) * 1990-05-18 1992-01-29 Nippon Synthetic Chem Ind Co Ltd:The Production of imidazole-4-chloro-5-carbaldehyde derivative
US5126342A (en) * 1990-10-01 1992-06-30 Merck & Co., Inc. Imidazole angiotensin ii antagonists incorporating acidic functional groups
EP0505098A1 (en) * 1991-03-19 1992-09-23 Merck & Co. Inc. Imidazole derivatives bearing acidic functional groups as angiotensin II antagonists
RU2103262C1 (en) * 1992-07-16 1998-01-27 Лонца АГ Гампель/Валлис Method for production of 2-substituted 5-chloroimidazole-4-carbaldehydes

Also Published As

Publication number Publication date
HUT66633A (en) 1994-12-28
DK0614890T3 (en) 1997-10-13
DE59407547D1 (en) 1999-02-11
EP0614891A3 (en) 1995-05-03
EP0614891B1 (en) 1998-12-30
HU9400736D0 (en) 1994-06-28
ATE157655T1 (en) 1997-09-15
DK0614891T3 (en) 1999-08-30
JP3716434B2 (en) 2005-11-16
EP0614890A3 (en) 1995-01-11
KR100362353B1 (en) 2003-03-19
DE59403903D1 (en) 1997-10-09
CA2117209C (en) 2005-05-31
HU219708B (en) 2001-06-28
HU213387B (en) 1997-05-28
CA2117209A1 (en) 1994-09-13
HU9701565D0 (en) 1997-11-28
ES2108894T3 (en) 1998-01-01
EP0614891A2 (en) 1994-09-14
EP0614890A2 (en) 1994-09-14
EP0614890B1 (en) 1997-09-03
CA2473422C (en) 2007-05-22
ATE175199T1 (en) 1999-01-15
JPH072789A (en) 1995-01-06
ES2127845T3 (en) 1999-05-01

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20140314