CA2471601A1 - Highly sensitive and continuous protein-tyrosine-phosphatase (ptpase) test using 6,8 difluoro-4-methyl-umbelliferylphosphate - Google Patents

Highly sensitive and continuous protein-tyrosine-phosphatase (ptpase) test using 6,8 difluoro-4-methyl-umbelliferylphosphate Download PDF

Info

Publication number
CA2471601A1
CA2471601A1 CA002471601A CA2471601A CA2471601A1 CA 2471601 A1 CA2471601 A1 CA 2471601A1 CA 002471601 A CA002471601 A CA 002471601A CA 2471601 A CA2471601 A CA 2471601A CA 2471601 A1 CA2471601 A1 CA 2471601A1
Authority
CA
Canada
Prior art keywords
compound
biological material
difluoro
difmup
protein tyrosine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002471601A
Other languages
English (en)
French (fr)
Inventor
Stefan Welte
Norbert Tennagels
Stefan Petry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2002100173 external-priority patent/DE10200173A1/de
Priority claimed from DE2002136329 external-priority patent/DE10236329A1/de
Application filed by Individual filed Critical Individual
Publication of CA2471601A1 publication Critical patent/CA2471601A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002471601A 2002-01-04 2002-12-24 Highly sensitive and continuous protein-tyrosine-phosphatase (ptpase) test using 6,8 difluoro-4-methyl-umbelliferylphosphate Abandoned CA2471601A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE10200173.1 2002-01-04
DE2002100173 DE10200173A1 (de) 2002-01-04 2002-01-04 Ein hochsensitiver und kontinuerlicher Protein Tyrosin-Phosphatase (PTPase) Test unter Verwendung von 6,8 Difluoro-4-methyl-umbelliferylphosphat (DiFMUP)
DE10236329.3 2002-08-08
DE2002136329 DE10236329A1 (de) 2002-08-08 2002-08-08 Ein hochsensitiver und kontinuierlicher Protein Tyrosin-Phosphatase (PTPase) Test unter Verwendung von 6,8 Difluoro-4-methyl-umbelliferylphosphat (DiFMUP)
PCT/EP2002/014755 WO2003056029A2 (de) 2002-01-04 2002-12-24 EIN HOCHSENSITIVER UND KONTINUIERLICHER PROTEIN-TYROSIN-PHOSPHATASE (PTPase) TEST UNTER VERWENDUNG VON 6,8 DIFLUORO-4-METHYL-UMBELLIFERYLPHOSPHAT (DiFMUP)

Publications (1)

Publication Number Publication Date
CA2471601A1 true CA2471601A1 (en) 2003-07-10

Family

ID=26010898

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002471601A Abandoned CA2471601A1 (en) 2002-01-04 2002-12-24 Highly sensitive and continuous protein-tyrosine-phosphatase (ptpase) test using 6,8 difluoro-4-methyl-umbelliferylphosphate

Country Status (12)

Country Link
EP (1) EP1466009A2 (pt)
JP (1) JP2005512600A (pt)
KR (1) KR20040073539A (pt)
CN (1) CN1612939A (pt)
AU (1) AU2002361217A1 (pt)
BR (1) BR0215452A (pt)
CA (1) CA2471601A1 (pt)
IL (1) IL162832A0 (pt)
MX (1) MXPA04006361A (pt)
NO (1) NO20043244L (pt)
RU (1) RU2004123794A (pt)
WO (1) WO2003056029A2 (pt)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8278086B2 (en) 2007-01-25 2012-10-02 Roche Diagnostics Operations, Inc. Enhancement of vanadium-containing phosphatase inhibitors

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100350045C (zh) * 2003-08-21 2007-11-21 北京农业生物技术研究中心 玉米酪氨酸蛋白磷酸酶基因及其编码蛋白与应用
EP1949894B1 (en) * 2007-01-25 2016-06-29 Roche Diagnostics GmbH Enhancement of vanadium-containing phosphatase inhibitors by polyols
CN113155787A (zh) * 2020-12-29 2021-07-23 武汉合研生物医药科技有限公司 一种突变酶shp2 e76k的活性检测方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4072799A (en) * 1998-05-12 1999-12-13 American Home Products Corporation 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8278086B2 (en) 2007-01-25 2012-10-02 Roche Diagnostics Operations, Inc. Enhancement of vanadium-containing phosphatase inhibitors
US8563263B2 (en) 2007-01-25 2013-10-22 Roche Diagnostics Operations Inc. Enhancement of vanadium-containing phosphatase inhibitors

Also Published As

Publication number Publication date
NO20043244L (no) 2004-08-02
RU2004123794A (ru) 2005-04-20
KR20040073539A (ko) 2004-08-19
IL162832A0 (en) 2005-11-20
BR0215452A (pt) 2004-11-23
CN1612939A (zh) 2005-05-04
JP2005512600A (ja) 2005-05-12
AU2002361217A1 (en) 2003-07-15
WO2003056029A2 (de) 2003-07-10
MXPA04006361A (es) 2004-10-04
WO2003056029A3 (de) 2004-04-01
EP1466009A2 (de) 2004-10-13

Similar Documents

Publication Publication Date Title
Zhang Protein-tyrosine phosphatases: biological function, structural characteristics, and mechanism of catalysis
Mazorra et al. Acid and alkaline phosphatase activities in the clam Scrobicularia plana: kinetic characteristics and effects of heavy metals
Ángel Sentandreu et al. A fluorescence-based protocol for quantifying angiotensin-converting enzyme activity
Wang et al. An extract of Artemisia dracunculus L. enhances insulin receptor signaling and modulates gene expression in skeletal muscle in KK-Ay mice
US8709711B2 (en) Methods of measuring cell viability in tissue engineered products
JPH0698032B2 (ja) クレアチンもしくはクレアチニンの測定法及びこれらの測定用試薬
US20030180827A1 (en) Highly sensitive and continuous protein tyrosine phosphatase test using 6,8-difluoro-4-methylumbelliferyl phosphate
CA2471601A1 (en) Highly sensitive and continuous protein-tyrosine-phosphatase (ptpase) test using 6,8 difluoro-4-methyl-umbelliferylphosphate
Volpe et al. A bienzyme electrochemical probe for flow injection analysis of okadaic acid based on protein phosphatase-2A inhibition: an optimization study
Falugi et al. Cholinesterase activity and effects of its inhibition by neurotoxic drugs in Dictyostelium discoideum
EP1497453B1 (en) Methods for measuring protein kinase and phosphatase activity
Zimmerman A rapid assay for pectinesterase activity which can be used as a prescreen for pectinesterase inhibitors
ZA200404694B (en) Highly sensitive and continous protein-tyrosine-phosphatase (ptpase) test using 6,8 diflouro-4-methyl-umbelliferylphosphate.
Clausse et al. Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens
Furlanello et al. Validation of an automated spectrophotometric assay for the determination of cholinesterase activity in canine serum
Krishnamurthy et al. Profiling protein tyrosine phosphatase activity with mechanistic probes
Rininsland et al. High-throughput kinase assays with protein substrates using fluorescent polymer superquenching
US20050004068A1 (en) Modulation of tor
CN105164273B (zh) 人类胰脂肪酶活性的测定方法
WO1993013219A1 (en) Calcium ion determining composition
Osawa et al. Development and application of serum cholinesterase activity measurement using benzoylthiocholine iodide
JPH07303497A (ja) 生体成分の測定方法および測定用試薬組成物
Infusino et al. Enzymes and Their Clinical Use
Nishikata et al. Continuous assay of protein tyrosine phosphatases based on fluorescence resonance energy transfer
KR20230136425A (ko) 혈당측정기를 이용한 미생물 독소 검출 방법

Legal Events

Date Code Title Description
FZDE Discontinued