CA2465517C - Greffes a stent tubulaire extensible radialement eluant les medicaments - Google Patents

Greffes a stent tubulaire extensible radialement eluant les medicaments Download PDF

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Publication number
CA2465517C
CA2465517C CA2465517A CA2465517A CA2465517C CA 2465517 C CA2465517 C CA 2465517C CA 2465517 A CA2465517 A CA 2465517A CA 2465517 A CA2465517 A CA 2465517A CA 2465517 C CA2465517 C CA 2465517C
Authority
CA
Canada
Prior art keywords
carbons
drug eluting
stent
stented graft
graft
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2465517A
Other languages
English (en)
Other versions
CA2465517A1 (fr
Inventor
Donald T. Shannon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Edwards Lifesciences Corp
Original Assignee
Edwards Lifesciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/997,829 external-priority patent/US20020042645A1/en
Application filed by Edwards Lifesciences Corp filed Critical Edwards Lifesciences Corp
Publication of CA2465517A1 publication Critical patent/CA2465517A1/fr
Application granted granted Critical
Publication of CA2465517C publication Critical patent/CA2465517C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts
    • A61F2002/075—Stent-grafts the stent being loosely attached to the graft material, e.g. by stitching
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention porte sur des greffes à stent tubulaire éluant les médicaments, le stent étant recouvert d'un revêtement comprenant un composite constitué d'au moins un polymère bioérodable, acceptable d'un point de vue pharmaceutique, biocompatible et d'au moins une substance thérapeutique. Le polymère peut être un polyester. L'agent thérapeutique peut comprendre des vecteurs d'administration de gènes sélectifs tels que le sirolimus, l'actinomycine D et le paclitaxel. Les greffes à stent tubulaire ont, selon les formes d'exécution, un stent intégré et un stent intérieur, le stent pouvant soit s'autodilater, soit se dilater sous pression. Le stent peut également comprendre une pluralité d'éléments ayant chacun une forme linéaire ondulante créée dans une configuration généralement cylindrique, chaque élément étant raccordé à un élément adjacent par au moins un raccord linéaire. L'invention porte, en outre, sur un procédé de traitement des maladies cardio-vasculaires par implantation de la greffe à stent, et sur un article de fabrication comprenant un matériau de conditionnement et la greffe à stent.
CA2465517A 2001-10-31 2002-10-31 Greffes a stent tubulaire extensible radialement eluant les medicaments Expired - Fee Related CA2465517C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US176501A 2001-10-31 2001-10-31
US10/001,765 2001-10-31
US09/997,829 2001-11-29
US09/997,829 US20020042645A1 (en) 1996-07-03 2001-11-29 Drug eluting radially expandable tubular stented grafts
PCT/US2002/035065 WO2003037397A2 (fr) 2001-10-31 2002-10-31 Greffes a stent tubulaire extensible radialement eluant les medicaments

Publications (2)

Publication Number Publication Date
CA2465517A1 CA2465517A1 (fr) 2003-05-08
CA2465517C true CA2465517C (fr) 2011-08-23

Family

ID=26669453

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2465517A Expired - Fee Related CA2465517C (fr) 2001-10-31 2002-10-31 Greffes a stent tubulaire extensible radialement eluant les medicaments

Country Status (4)

Country Link
EP (1) EP1439868A2 (fr)
JP (1) JP2005507710A (fr)
CA (1) CA2465517C (fr)
WO (1) WO2003037397A2 (fr)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040024448A1 (en) * 2002-08-05 2004-02-05 Chang James W. Thermoplastic fluoropolymer-coated medical devices
JP4971580B2 (ja) * 2003-06-05 2012-07-11 テルモ株式会社 ステントおよびステントの製造方法
ES2383374T3 (es) * 2003-12-24 2012-06-20 Novartis Ag Dispositivos recubiertos con polímeros de PEC
EP1811933B1 (fr) 2004-09-28 2016-03-23 Atrium Medical Corporation Couche barriere
US20060088596A1 (en) 2004-09-28 2006-04-27 Atrium Medical Corporation Solubilizing a drug for use in a coating
US9000040B2 (en) 2004-09-28 2015-04-07 Atrium Medical Corporation Cross-linked fatty acid-based biomaterials
US9012506B2 (en) 2004-09-28 2015-04-21 Atrium Medical Corporation Cross-linked fatty acid-based biomaterials
US9801982B2 (en) 2004-09-28 2017-10-31 Atrium Medical Corporation Implantable barrier device
US9278161B2 (en) 2005-09-28 2016-03-08 Atrium Medical Corporation Tissue-separating fatty acid adhesion barrier
US9427423B2 (en) 2009-03-10 2016-08-30 Atrium Medical Corporation Fatty-acid based particles
AU2006304590A1 (en) 2005-10-15 2007-04-26 Atrium Medical Corporation Hydrophobic cross-linked gels for bioabsorbable drug carrier coatings
US9492596B2 (en) 2006-11-06 2016-11-15 Atrium Medical Corporation Barrier layer with underlying medical device and one or more reinforcing support structures
EP2083875B1 (fr) 2006-11-06 2013-03-27 Atrium Medical Corporation Filet chirurgical enrobe
US20110038910A1 (en) 2009-08-11 2011-02-17 Atrium Medical Corporation Anti-infective antimicrobial-containing biomaterials
US10322213B2 (en) 2010-07-16 2019-06-18 Atrium Medical Corporation Compositions and methods for altering the rate of hydrolysis of cured oil-based materials
US9867880B2 (en) 2012-06-13 2018-01-16 Atrium Medical Corporation Cured oil-hydrogel biomaterial compositions for controlled drug delivery
WO2014031950A1 (fr) 2012-08-24 2014-02-27 Herskovic Arnold M Dispositif et procédé visant à améliorer la curiethérapie
US10543379B2 (en) 2015-10-23 2020-01-28 Boston Scientific Scimed, Inc. Radioactive stents
CN108013955B (zh) 2016-11-04 2020-01-10 先健科技(深圳)有限公司 血管支架
US20210121180A1 (en) * 2019-10-24 2021-04-29 Atrium Medical Corporation Endovascular fixation device
CN117838403A (zh) * 2022-09-30 2024-04-09 深圳市先健纬康科技有限公司 血管支架
CN115671407B (zh) * 2022-10-25 2024-01-30 赛诺神畅医疗科技有限公司 一种自膨式药物洗脱支架***及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4131648A (en) * 1975-01-28 1978-12-26 Alza Corporation Structured orthoester and orthocarbonate drug delivery devices
US5797870A (en) * 1995-06-07 1998-08-25 Indiana University Foundation Pericardial delivery of therapeutic and diagnostic agents
US5928279A (en) * 1996-07-03 1999-07-27 Baxter International Inc. Stented, radially expandable, tubular PTFE grafts
US6623521B2 (en) * 1998-02-17 2003-09-23 Md3, Inc. Expandable stent with sliding and locking radial elements
US6224626B1 (en) * 1998-02-17 2001-05-01 Md3, Inc. Ultra-thin expandable stent
JP2002534165A (ja) * 1998-12-31 2002-10-15 アンジオテック ファーマシューティカルズ，インコーポレイテッド 生物活性被覆を備えたステント移植片
US6241719B1 (en) * 1999-05-13 2001-06-05 Micro Therapeutics, Inc. Method for forming a radioactive stent
AU2001286940A1 (en) * 2000-09-22 2002-04-02 Kensey Nash Corporation Drug delivering prostheses and methods of use
US6254632B1 (en) * 2000-09-28 2001-07-03 Advanced Cardiovascular Systems, Inc. Implantable medical device having protruding surface structures for drug delivery and cover attachment

Also Published As

Publication number Publication date
JP2005507710A (ja) 2005-03-24
WO2003037397A3 (fr) 2003-09-18
EP1439868A2 (fr) 2004-07-28
CA2465517A1 (fr) 2003-05-08
WO2003037397A2 (fr) 2003-05-08

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Effective date: 20171031