CA2461074A1 - Methodes et compositions faisant intervenir de nouvelles triazines - Google Patents
Methodes et compositions faisant intervenir de nouvelles triazines Download PDFInfo
- Publication number
- CA2461074A1 CA2461074A1 CA002461074A CA2461074A CA2461074A1 CA 2461074 A1 CA2461074 A1 CA 2461074A1 CA 002461074 A CA002461074 A CA 002461074A CA 2461074 A CA2461074 A CA 2461074A CA 2461074 A1 CA2461074 A1 CA 2461074A1
- Authority
- CA
- Canada
- Prior art keywords
- triazine
- methyl
- triamine
- cycloheptyl
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/42—One nitrogen atom
- C07D251/44—One nitrogen atom with halogen atoms attached to the two other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/42—One nitrogen atom
- C07D251/46—One nitrogen atom with oxygen or sulfur atoms attached to the two other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
- C07D251/50—Two nitrogen atoms with a halogen atom attached to the third ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
- C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/54—Three nitrogen atoms
- C07D251/70—Other substituted melamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Cosmetics (AREA)
Abstract
La présente invention concerne des méthodes et des compositions faisant intervenir des composés destinés au traitement d'états pathophysiologiques générés par des réponses inflammatoires. La présente invention concerne, en particulier, des composés inhibant ou bloquant l'induction produite par des protéines glyquées de réponses inflammatoires associées à la signalisation dans les cellules endothéliales. La présente invention concerne des composés inhibant la prolifération du muscle lisse. La présente invention concerne, en particulier, des composés inhibant la prolifération des cellules du muscle lisse par modulation des HSPG, tels que le perlecan. La présente invention concerne également l'utilisation de composés destinés au traitement de vasculopathies occlusives caractérisées par une prolifération du muscle lisse, tels que la resténose et l'athérosclérose.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32414701P | 2001-09-21 | 2001-09-21 | |
US60/324,147 | 2001-09-21 | ||
PCT/US2002/030177 WO2003024926A2 (fr) | 2001-09-21 | 2002-09-23 | Methodes et compositions faisant intervenir de nouvelles triazines |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2461074A1 true CA2461074A1 (fr) | 2003-03-27 |
Family
ID=23262298
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002461074A Abandoned CA2461074A1 (fr) | 2001-09-21 | 2002-09-23 | Methodes et compositions faisant intervenir de nouvelles triazines |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP1436266A4 (fr) |
JP (1) | JP2005511509A (fr) |
KR (1) | KR20040088457A (fr) |
CN (1) | CN1578773A (fr) |
BR (1) | BR0212895A (fr) |
CA (1) | CA2461074A1 (fr) |
EA (1) | EA009728B1 (fr) |
IL (1) | IL160984A0 (fr) |
IS (1) | IS7190A (fr) |
MX (1) | MXPA04002680A (fr) |
NO (1) | NO20041187L (fr) |
NZ (1) | NZ532349A (fr) |
PL (1) | PL369600A1 (fr) |
RS (1) | RS34004A (fr) |
WO (1) | WO2003024926A2 (fr) |
ZA (1) | ZA200403009B (fr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7173032B2 (en) * | 2001-09-21 | 2007-02-06 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
US7112587B2 (en) | 2001-09-21 | 2006-09-26 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
US7132423B2 (en) | 2001-09-21 | 2006-11-07 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
US7169785B2 (en) | 2001-09-21 | 2007-01-30 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
US7163943B2 (en) | 2001-09-21 | 2007-01-16 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
CN1625410A (zh) | 2002-02-05 | 2005-06-08 | 山之内制药株式会社 | 2,4,6-三氨基-1,3,5-三嗪衍生物 |
AU2003253735A1 (en) * | 2002-06-25 | 2004-01-06 | The Center For Blood Research, Inc. | Vacuolins |
WO2005009980A1 (fr) * | 2003-07-22 | 2005-02-03 | Neurogen Corporation | Analogues de pyridin-2-ylamine substitues |
CN1629157A (zh) * | 2003-12-19 | 2005-06-22 | 中国科学院上海药物研究所 | 哌嗪三嗪类化合物、其制备方法及药物组合物 |
US7335770B2 (en) | 2004-03-24 | 2008-02-26 | Reddy U5 Therapeutics, Inc. | Triazine compounds and their analogs, compositions, and methods |
ES2350803T3 (es) * | 2006-11-03 | 2011-01-27 | Nerviano Medical Sciences S.R.L. | Procedimiento de administración de un compuesto antitumoral. |
KR101314869B1 (ko) * | 2010-07-29 | 2013-10-04 | 광주과학기술원 | 트리아진계 화합물을 유효성분으로 포함하는 당뇨병 예방 또는 치료용 약제학적 조성물 |
US20120295911A1 (en) | 2010-11-29 | 2012-11-22 | Galleon Pharmaceuticals, Inc. | Novel Compounds and Compositions for Treatment of Breathing Control Disorders or Diseases |
JP5907986B2 (ja) * | 2010-11-29 | 2016-04-26 | ガリオン ファーマシューティカルズ インコーポレイテッド | 呼吸制御障害または呼吸制御疾患の処置用の呼吸刺激薬としての化合物 |
US10604492B2 (en) * | 2015-12-24 | 2020-03-31 | The Regents Of The Universtiy Of California | CFTR regulators and methods of use thereof |
KR20200044873A (ko) | 2017-08-24 | 2020-04-29 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 안구 제약학적 조성물 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2083568C1 (ru) * | 1994-05-05 | 1997-07-10 | Кубанский государственный аграрный университет | Соли триазинкарбоновых кислот и средство для предпосевной обработки семян сельскохозяйственных культур |
DE19531084A1 (de) * | 1995-08-24 | 1997-02-27 | Hoechst Schering Agrevo Gmbh | 2,4-Diamino-1,3,5-triazine, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
ATE239012T1 (de) * | 1997-12-12 | 2003-05-15 | Abbott Lab | Triazin angiogenese-inhibitoren |
EP0945447A1 (fr) * | 1998-03-27 | 1999-09-29 | Janssen Pharmaceutica N.V. | Dérivés de 1,3,5-triazine trisubstituées pour le traitement de l'infection par le VIH |
JP4794793B2 (ja) * | 1999-12-28 | 2011-10-19 | ファーマコペイア, インコーポレイテッド | N−ヘテロ環TNF−α発現阻害剤 |
AU2002216650A1 (en) * | 2000-10-31 | 2002-05-15 | Lynn Bonham | Triazine derivatives as lpaat-b inhibitors and uses thereof |
-
2002
- 2002-09-23 JP JP2003528774A patent/JP2005511509A/ja active Pending
- 2002-09-23 EP EP02799019A patent/EP1436266A4/fr not_active Withdrawn
- 2002-09-23 PL PL02369600A patent/PL369600A1/xx not_active Application Discontinuation
- 2002-09-23 BR BR0212895-0A patent/BR0212895A/pt not_active IP Right Cessation
- 2002-09-23 WO PCT/US2002/030177 patent/WO2003024926A2/fr active Application Filing
- 2002-09-23 MX MXPA04002680A patent/MXPA04002680A/es active IP Right Grant
- 2002-09-23 RS YU34004A patent/RS34004A/sr unknown
- 2002-09-23 CN CNA028232402A patent/CN1578773A/zh active Pending
- 2002-09-23 CA CA002461074A patent/CA2461074A1/fr not_active Abandoned
- 2002-09-23 EA EA200400464A patent/EA009728B1/ru not_active IP Right Cessation
- 2002-09-23 KR KR10-2004-7004179A patent/KR20040088457A/ko not_active Application Discontinuation
- 2002-09-23 IL IL16098402A patent/IL160984A0/xx unknown
- 2002-09-23 NZ NZ532349A patent/NZ532349A/en unknown
-
2004
- 2004-03-19 IS IS7190A patent/IS7190A/is unknown
- 2004-03-22 NO NO20041187A patent/NO20041187L/no not_active Application Discontinuation
- 2004-04-20 ZA ZA200403009A patent/ZA200403009B/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR20040088457A (ko) | 2004-10-16 |
JP2005511509A (ja) | 2005-04-28 |
EA200400464A1 (ru) | 2005-02-24 |
CN1578773A (zh) | 2005-02-09 |
IL160984A0 (en) | 2004-08-31 |
BR0212895A (pt) | 2005-05-10 |
MXPA04002680A (es) | 2004-06-18 |
ZA200403009B (en) | 2007-12-27 |
NZ532349A (en) | 2007-02-23 |
IS7190A (is) | 2004-03-19 |
EP1436266A4 (fr) | 2004-12-22 |
EP1436266A2 (fr) | 2004-07-14 |
WO2003024926A2 (fr) | 2003-03-27 |
WO2003024926A3 (fr) | 2003-12-11 |
EA009728B1 (ru) | 2008-02-28 |
RS34004A (en) | 2006-10-27 |
NO20041187L (no) | 2004-05-19 |
PL369600A1 (en) | 2005-05-02 |
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US7332490B2 (en) | Methods and compositions of novel triazine compounds | |
CA2461074A1 (fr) | Methodes et compositions faisant intervenir de nouvelles triazines | |
AU2002362314A1 (en) | Methods and compositions of novel triazine compounds | |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Discontinued |