CA2456322A1 - Compositions et methodes destinees a prevenir l'abus d'opioides - Google Patents
Compositions et methodes destinees a prevenir l'abus d'opioides Download PDFInfo
- Publication number
- CA2456322A1 CA2456322A1 CA002456322A CA2456322A CA2456322A1 CA 2456322 A1 CA2456322 A1 CA 2456322A1 CA 002456322 A CA002456322 A CA 002456322A CA 2456322 A CA2456322 A CA 2456322A CA 2456322 A1 CA2456322 A1 CA 2456322A1
- Authority
- CA
- Canada
- Prior art keywords
- dosage form
- opioid
- oral dosage
- antagonist
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 238000000034 method Methods 0.000 title claims abstract description 70
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- 239000003795 chemical substances by application Substances 0.000 claims abstract description 190
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- TZZAKSLHHIJRLL-UHFFFAOYSA-N 4-hydroxy-3-methoxybenzamide Chemical group COC1=CC(C(N)=O)=CC=C1O TZZAKSLHHIJRLL-UHFFFAOYSA-N 0.000 claims description 2
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention concerne des méthodes et des compositions destinées à prévenir l'abus de formes posologiques d'un analgésique opioïde et d'un antagoniste opioïde comprenant au moins un agent aversif en une quantité efficace pour empêcher un consommateur abusif de s'administrer une forme trafiquée de ladite forme posologique par voie intraveineuse, intranasale et/ou orale.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31053701P | 2001-08-06 | 2001-08-06 | |
US31051601P | 2001-08-06 | 2001-08-06 | |
US31051501P | 2001-08-06 | 2001-08-06 | |
US60/310,516 | 2001-08-06 | ||
US60/310,537 | 2001-08-06 | ||
US60/310,515 | 2001-08-06 | ||
PCT/US2002/024934 WO2003013479A1 (fr) | 2001-08-06 | 2002-08-06 | Compositions et methodes destinees a prevenir l'abus d'opioides |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2456322A1 true CA2456322A1 (fr) | 2003-02-20 |
Family
ID=27405462
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002456322A Abandoned CA2456322A1 (fr) | 2001-08-06 | 2002-08-06 | Compositions et methodes destinees a prevenir l'abus d'opioides |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1414418A1 (fr) |
JP (1) | JP2005501067A (fr) |
KR (1) | KR20040060917A (fr) |
AU (1) | AU2002319774B2 (fr) |
BR (1) | BR0212019A (fr) |
CA (1) | CA2456322A1 (fr) |
DE (1) | DE20220910U1 (fr) |
HU (1) | HUP0401195A3 (fr) |
MX (1) | MXPA04001208A (fr) |
WO (1) | WO2003013479A1 (fr) |
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US9629807B2 (en) | 2003-08-06 | 2017-04-25 | Grünenthal GmbH | Abuse-proofed dosage form |
US9636303B2 (en) | 2010-09-02 | 2017-05-02 | Gruenenthal Gmbh | Tamper resistant dosage form comprising an anionic polymer |
US9655853B2 (en) | 2012-02-28 | 2017-05-23 | Grünenthal GmbH | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
US9675610B2 (en) | 2002-06-17 | 2017-06-13 | Grünenthal GmbH | Abuse-proofed dosage form |
US9737490B2 (en) | 2013-05-29 | 2017-08-22 | Grünenthal GmbH | Tamper resistant dosage form with bimodal release profile |
US9750701B2 (en) | 2008-01-25 | 2017-09-05 | Grünenthal GmbH | Pharmaceutical dosage form |
US9855263B2 (en) | 2015-04-24 | 2018-01-02 | Grünenthal GmbH | Tamper-resistant dosage form with immediate release and resistance against solvent extraction |
US9872835B2 (en) | 2014-05-26 | 2018-01-23 | Grünenthal GmbH | Multiparticles safeguarded against ethanolic dose-dumping |
US9913814B2 (en) | 2014-05-12 | 2018-03-13 | Grünenthal GmbH | Tamper resistant immediate release capsule formulation comprising tapentadol |
US9925146B2 (en) | 2009-07-22 | 2018-03-27 | Grünenthal GmbH | Oxidation-stabilized tamper-resistant dosage form |
US10058548B2 (en) | 2003-08-06 | 2018-08-28 | Grünenthal GmbH | Abuse-proofed dosage form |
US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
US10080721B2 (en) | 2009-07-22 | 2018-09-25 | Gruenenthal Gmbh | Hot-melt extruded pharmaceutical dosage form |
US10130591B2 (en) | 2003-08-06 | 2018-11-20 | Grünenthal GmbH | Abuse-proofed dosage form |
US10154966B2 (en) | 2013-05-29 | 2018-12-18 | Grünenthal GmbH | Tamper-resistant dosage form containing one or more particles |
US10201502B2 (en) | 2011-07-29 | 2019-02-12 | Gruenenthal Gmbh | Tamper-resistant tablet providing immediate drug release |
US10300141B2 (en) | 2010-09-02 | 2019-05-28 | Grünenthal GmbH | Tamper resistant dosage form comprising inorganic salt |
US10335373B2 (en) | 2012-04-18 | 2019-07-02 | Grunenthal Gmbh | Tamper resistant and dose-dumping resistant pharmaceutical dosage form |
US10449547B2 (en) | 2013-11-26 | 2019-10-22 | Grünenthal GmbH | Preparation of a powdery pharmaceutical composition by means of cryo-milling |
US10624862B2 (en) | 2013-07-12 | 2020-04-21 | Grünenthal GmbH | Tamper-resistant dosage form containing ethylene-vinyl acetate polymer |
US10695297B2 (en) | 2011-07-29 | 2020-06-30 | Grünenthal GmbH | Tamper-resistant tablet providing immediate drug release |
US10729658B2 (en) | 2005-02-04 | 2020-08-04 | Grünenthal GmbH | Process for the production of an abuse-proofed dosage form |
US10842750B2 (en) | 2015-09-10 | 2020-11-24 | Grünenthal GmbH | Protecting oral overdose with abuse deterrent immediate release formulations |
WO2022006200A1 (fr) * | 2020-07-01 | 2022-01-06 | Capsugel Belgium Nv | Composition alimentaire et procédé |
US11224576B2 (en) | 2003-12-24 | 2022-01-18 | Grünenthal GmbH | Process for the production of an abuse-proofed dosage form |
US11844865B2 (en) | 2004-07-01 | 2023-12-19 | Grünenthal GmbH | Abuse-proofed oral dosage form |
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FR2949062B1 (fr) | 2009-08-12 | 2011-09-02 | Debregeas Et Associes Pharma | Nouvelles formulations pharmaceutiques contre le mesusage des medicaments |
FR2949061B1 (fr) | 2009-08-12 | 2013-04-19 | Debregeas Et Associes Pharma | Microgranules flottants |
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WO2011141490A1 (fr) | 2010-05-10 | 2011-11-17 | Euro-Celtique S.A. | Combinaison de granules chargés de principe actif et de principes actifs supplémentaires |
BR112012028788A2 (pt) | 2010-05-10 | 2016-07-19 | Euro Celtique Sa | fabricação de grânulos sem ativos |
US9700508B2 (en) | 2010-05-10 | 2017-07-11 | Euro-Celtique S.A. | Pharmaceutical compositions comprising hydromorphone and naloxone |
CN103327969A (zh) * | 2010-12-23 | 2013-09-25 | 普渡制药公司 | 抗篡改固体口服剂型 |
JP2014505736A (ja) * | 2011-02-17 | 2014-03-06 | キューアールエックスファーマ リミテッド | 固体投薬形態の乱用を防止するための技術 |
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LT3730132T (lt) | 2012-06-06 | 2022-08-25 | Nalpropion Pharmaceuticals Llc | Kompozicija, skirta panaudoti pacientų su didele širdies ir kraujagyslių ligų rizika antsvorio ir nutukimo gydymo būde |
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US10751287B2 (en) | 2013-03-15 | 2020-08-25 | Purdue Pharma L.P. | Tamper resistant pharmaceutical formulations |
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US9132096B1 (en) | 2014-09-12 | 2015-09-15 | Alkermes Pharma Ireland Limited | Abuse resistant pharmaceutical compositions |
US10729685B2 (en) | 2014-09-15 | 2020-08-04 | Ohemo Life Sciences Inc. | Orally administrable compositions and methods of deterring abuse by intranasal administration |
MX2018011799A (es) * | 2016-03-31 | 2019-01-24 | SpecGx LLC | Formas de dosificacion de liberacion prolongada disuasivas de abuso. |
EP3473246A1 (fr) | 2017-10-19 | 2019-04-24 | Capsugel Belgium NV | Formulations anti-abus à libération immédiate |
KR102140493B1 (ko) * | 2019-05-30 | 2020-08-03 | 충북대학교 산학협력단 | 데나토늄을 유효성분으로 포함하는 골 질환의 예방 또는 치료용 조성물 |
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US6375957B1 (en) * | 1997-12-22 | 2002-04-23 | Euro-Celtique, S.A. | Opioid agonist/opioid antagonist/acetaminophen combinations |
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2002
- 2002-08-06 AU AU2002319774A patent/AU2002319774B2/en not_active Ceased
- 2002-08-06 WO PCT/US2002/024934 patent/WO2003013479A1/fr not_active Application Discontinuation
- 2002-08-06 EP EP02750438A patent/EP1414418A1/fr not_active Withdrawn
- 2002-08-06 MX MXPA04001208A patent/MXPA04001208A/es unknown
- 2002-08-06 CA CA002456322A patent/CA2456322A1/fr not_active Abandoned
- 2002-08-06 BR BR0212019-4A patent/BR0212019A/pt not_active Application Discontinuation
- 2002-08-06 HU HU0401195A patent/HUP0401195A3/hu unknown
- 2002-08-06 KR KR10-2004-7001878A patent/KR20040060917A/ko not_active Application Discontinuation
- 2002-08-06 JP JP2003518489A patent/JP2005501067A/ja active Pending
- 2002-08-06 DE DE20220910U patent/DE20220910U1/de not_active Expired - Lifetime
Cited By (32)
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US9675610B2 (en) | 2002-06-17 | 2017-06-13 | Grünenthal GmbH | Abuse-proofed dosage form |
US10369109B2 (en) | 2002-06-17 | 2019-08-06 | Grünenthal GmbH | Abuse-proofed dosage form |
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Also Published As
Publication number | Publication date |
---|---|
DE20220910U1 (de) | 2004-08-05 |
MXPA04001208A (es) | 2004-07-08 |
EP1414418A1 (fr) | 2004-05-06 |
HUP0401195A3 (en) | 2006-11-28 |
AU2002319774B2 (en) | 2005-04-21 |
JP2005501067A (ja) | 2005-01-13 |
HUP0401195A2 (hu) | 2004-10-28 |
WO2003013479A1 (fr) | 2003-02-20 |
KR20040060917A (ko) | 2004-07-06 |
BR0212019A (pt) | 2005-08-09 |
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