CA2432278A1 - Methodes et compositions relatives a un facteur nucleaire regulateur specifique du muscle cardiaque - Google Patents
Methodes et compositions relatives a un facteur nucleaire regulateur specifique du muscle cardiaque Download PDFInfo
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- CA2432278A1 CA2432278A1 CA002432278A CA2432278A CA2432278A1 CA 2432278 A1 CA2432278 A1 CA 2432278A1 CA 002432278 A CA002432278 A CA 002432278A CA 2432278 A CA2432278 A CA 2432278A CA 2432278 A1 CA2432278 A1 CA 2432278A1
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- C—CHEMISTRY; METALLURGY
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
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- Immunology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
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- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention concerne un nouveau facteur de transcription spécifique du muscle cardiaque, le myocarde. Cette molécule module le développement et la différenciation des cardiomyocytes et constitue un inhibiteur puissant de la croissance cellulaire. Par ailleurs, l'invention concerne des méthodes d'exploitation de ces observations, lesquelles consistent à respécifier les cellules non cardiaques en cellules cardiaques et à stimuler la régénération des tissus cardiaques, ainsi que des méthodes de traitement des cardiomyopathies et de l'infarctus du myocarde.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25771600P | 2000-12-21 | 2000-12-21 | |
| US60/257,716 | 2000-12-21 | ||
| PCT/US2001/050606 WO2002060946A2 (fr) | 2000-12-21 | 2001-12-21 | Methodes et compositions relatives a un facteur nucleaire regulateur specifique du muscle cardiaque |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2432278A1 true CA2432278A1 (fr) | 2002-08-08 |
Family
ID=22977449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002432278A Abandoned CA2432278A1 (fr) | 2000-12-21 | 2001-12-21 | Methodes et compositions relatives a un facteur nucleaire regulateur specifique du muscle cardiaque |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP1345962A2 (fr) |
| CA (1) | CA2432278A1 (fr) |
| WO (1) | WO2002060946A2 (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7803765B2 (en) | 1999-05-05 | 2010-09-28 | Phylogica Limited | Methods of constructing biodiverse gene fragment libraries and biological modulators isolated therefrom |
| CA2568644C (fr) * | 2004-06-03 | 2015-11-24 | Phylogica Limited | Modulateurs peptidiques du phenotype cellulaire et base de fragments d'acide binucleique |
| WO2010094757A1 (fr) * | 2009-02-23 | 2010-08-26 | F. Hoffmann-La Roche Ag | Utilisation de cardiomyocytes humains primaires |
| BR112021003897A2 (pt) * | 2018-08-30 | 2021-05-25 | Tenaya Therapeutics, Inc. | reprogramação de células cardíacas com miocarina e asci1 |
-
2001
- 2001-12-21 WO PCT/US2001/050606 patent/WO2002060946A2/fr not_active Application Discontinuation
- 2001-12-21 EP EP01998118A patent/EP1345962A2/fr not_active Withdrawn
- 2001-12-21 CA CA002432278A patent/CA2432278A1/fr not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1345962A2 (fr) | 2003-09-24 |
| WO2002060946A2 (fr) | 2002-08-08 |
| WO2002060946A3 (fr) | 2003-06-05 |
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| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Dead |