CA2424359A1 - Implants with a phosphazene-containing coating - Google Patents

Implants with a phosphazene-containing coating Download PDF

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Publication number
CA2424359A1
CA2424359A1 CA002424359A CA2424359A CA2424359A1 CA 2424359 A1 CA2424359 A1 CA 2424359A1 CA 002424359 A CA002424359 A CA 002424359A CA 2424359 A CA2424359 A CA 2424359A CA 2424359 A1 CA2424359 A1 CA 2424359A1
Authority
CA
Canada
Prior art keywords
active agent
artificial implant
substrate
implant according
coating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002424359A
Other languages
French (fr)
Other versions
CA2424359C (en
Inventor
Stefan Nagel
Michael Boxberger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celonova Biosciences Germany GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2424359A1 publication Critical patent/CA2424359A1/en
Application granted granted Critical
Publication of CA2424359C publication Critical patent/CA2424359C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/068—Use of macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Abstract

The invention relates to artificial implants with a biocompatible surface which has antithrombitic properties, furthermore contains a pharmacologicall y active ingredient and a method for production thereof.

Claims (12)

1. Artificial implant comprising an implant material as the substrate and a biocompatible coating applied at least partly to the surface of the substrate, which coating comprises an antithrombogenic polymer having the following general formula (I) wherein R1 to R6 are the same or different and represent an alkoxy, alkylsulfonyl, dialkylamino or aryloxy group, or a heterocycloalkyl or heteroaryl group having nitrogen as the heteroatom, and at least one other pharmacologically active agent.
2. Artificial implant according to Claim 1, wherein at least one of the groups R1 to R6 is an alkoxy group substituted with at least one fluorine atom.
3. Artificial implant according to Claim 2, wherein the antithrombogenic polymer is poly[bis(trifluoroethoxy)phosphazene].
4. Artificial implant according to one of the Claims 1 to 3, wherein the other pharmacologically active agent is an antimitogenic active agent, especially a cytostatic, a PDGF antagonist, especially trapidil, or a Raf-1 kinase inhibitor.
5. Artificial implant according to one of the Claims 1 to 3, wherein the other pharmacologically active agent is a radical trap (especially probucol), an antisense active agent (especially plasmid DNA), a statin (especially cerivastatin) or a GP-IIb/IIIa receptor antagonist (especially abciximab).
6. Artificial implant according to one of the Claims 1 to 5, wherein the ratio of antithrombogenic polymer to active agent is from 1:0.0001 to 1:1, preferably from 1:0.05 to 1:0.5.
7. Artificial implant according to one of the Claims 1 to 6, wherein a layer containing an adhesion promoter is provided between the surface of the substrate and the biocompatible coating.
8. Artificial implant according to Claim 7, wherein the adhesion promoter is an organosilicon compound, especially aminopropyltrimethoxysilane.
9. Process for producing an artificial implant according to one of the Claims 1 to 8, wherein the biocompatible coating is applied to the substrate by reacting the substrate with (a) a mixture of the antithrombogenic polymer or a precursor of it and the active agent or (b) the antithrombogenic polymer or a precursor of it, to produce a primary polymer coating, and subsequent application/penetration of the active agent into the primary polymer coating.
10. Process according to Claim 9, wherein the coating is applied by wet chemistry, particularly by reacting the substrate with a mixture of antithrombogenic polymer and active agent.
11. Process according to Claim 10, wherein the solvent for the wet chemical application is selected from dipolar aprotic solvents and is preferably ethyl acetate.
12. Process according to Claims 9 to 11, wherein an adhesion promoter is applied to the surface of the substrate before the biocompatible coating is applied.
CA2424359A 2000-08-11 2001-08-01 Implants with a phosphazene-containing coating Expired - Lifetime CA2424359C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00117191.7 2000-08-11
EP00117191A EP1179353A1 (en) 2000-08-11 2000-08-11 Antithrombogenic implants with coating of polyphosphazenes and a pharmacologically active agent
PCT/EP2001/008913 WO2002013882A1 (en) 2000-08-11 2001-08-01 Implants with a phosphazene-containing coating

Publications (2)

Publication Number Publication Date
CA2424359A1 true CA2424359A1 (en) 2003-02-06
CA2424359C CA2424359C (en) 2012-03-20

Family

ID=8169492

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2424359A Expired - Lifetime CA2424359C (en) 2000-08-11 2001-08-01 Implants with a phosphazene-containing coating

Country Status (13)

Country Link
US (1) US20030157142A1 (en)
EP (2) EP1179353A1 (en)
JP (1) JP4886156B2 (en)
KR (1) KR100809134B1 (en)
CN (1) CN100467073C (en)
AT (1) ATE374626T1 (en)
AU (2) AU9544701A (en)
BR (1) BR0113184B1 (en)
CA (1) CA2424359C (en)
DE (1) DE50113094D1 (en)
DK (1) DK1337285T3 (en)
ES (1) ES2296811T3 (en)
WO (1) WO2002013882A1 (en)

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Also Published As

Publication number Publication date
KR100809134B1 (en) 2008-02-29
US20030157142A1 (en) 2003-08-21
AU2001295447B2 (en) 2007-01-04
BR0113184B1 (en) 2014-12-02
ATE374626T1 (en) 2007-10-15
AU9544701A (en) 2002-02-25
WO2002013882A1 (en) 2002-02-21
ES2296811T3 (en) 2008-05-01
JP2004522461A (en) 2004-07-29
EP1179353A1 (en) 2002-02-13
DE50113094D1 (en) 2007-11-15
CA2424359C (en) 2012-03-20
CN1469759A (en) 2004-01-21
CN100467073C (en) 2009-03-11
JP4886156B2 (en) 2012-02-29
KR20030061780A (en) 2003-07-22
DK1337285T3 (en) 2008-02-11
EP1337285A1 (en) 2003-08-27
BR0113184A (en) 2003-07-01
EP1337285B1 (en) 2007-10-03

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