CA2418134A1 - Oxazolyl-arylpropionic acid derivatives and their use as ppar agonists - Google Patents

Oxazolyl-arylpropionic acid derivatives and their use as ppar agonists Download PDF

Info

Publication number
CA2418134A1
CA2418134A1 CA002418134A CA2418134A CA2418134A1 CA 2418134 A1 CA2418134 A1 CA 2418134A1 CA 002418134 A CA002418134 A CA 002418134A CA 2418134 A CA2418134 A CA 2418134A CA 2418134 A1 CA2418134 A1 CA 2418134A1
Authority
CA
Canada
Prior art keywords
methyl
phenyl
oxazol
ethoxy
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002418134A
Other languages
English (en)
French (fr)
Inventor
Robert J. Ardecky
Dawn Alisa Brooks
Alexander Glenn Godfrey
Sarah Beth Jones
Nathan Bryan Mantlo
James Ray Mccarthy
Pierre-Yves Michellys
Christopher John Rito
John S. Tyhonas
Leonard Larry Winneroski
Yanping Xu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ligand Pharmaceuticals Inc
Eli Lilly and Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2418134A1 publication Critical patent/CA2418134A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA002418134A 2000-08-23 2001-08-23 Oxazolyl-arylpropionic acid derivatives and their use as ppar agonists Abandoned CA2418134A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22745600P 2000-08-23 2000-08-23
US60/227,456 2000-08-23
PCT/US2001/022617 WO2002016332A1 (en) 2000-08-23 2001-08-23 Oxazolyl-arylpropionic acid derivatives and their use as ppar agonists

Publications (1)

Publication Number Publication Date
CA2418134A1 true CA2418134A1 (en) 2002-02-28

Family

ID=22853183

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002418134A Abandoned CA2418134A1 (en) 2000-08-23 2001-08-23 Oxazolyl-arylpropionic acid derivatives and their use as ppar agonists

Country Status (10)

Country Link
US (1) US7176224B2 (de)
EP (1) EP1313717B1 (de)
JP (1) JP2004506722A (de)
AT (1) ATE375985T1 (de)
AU (1) AU2001284660A1 (de)
CA (1) CA2418134A1 (de)
DE (1) DE60131001T2 (de)
ES (1) ES2295200T3 (de)
MX (1) MXPA03001610A (de)
WO (1) WO2002016332A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004506721A (ja) 2000-08-23 2004-03-04 イーライ・リリー・アンド・カンパニー オキサゾリル−アリールプロピオン酸誘導体およびそのｐｐａｒアゴニストとしての使用
AU2001284658A1 (en) * 2000-08-23 2002-03-13 Eli Lilly And Company Oxazolyl-aryloxyacetic acid derivatives and their use as ppar agonists
IL159002A0 (en) * 2001-06-07 2004-05-12 Lilly Co Eli Modulators of peroxisome proliferator activated receptors (ppar)
NZ529351A (en) * 2001-06-07 2006-01-27 Lilly Co Eli Modulators of peroxisome proliferator activated receptors
MXPA04003398A (es) * 2001-10-12 2004-11-22 Nippon Chemiphar Co Activador para el receptor o activado con el proliferador de peroxisoma.
US20050080115A1 (en) * 2002-10-28 2005-04-14 Lone Jeppesen Novel compounds, their preparation and use
PL210871B1 (pl) 2002-11-08 2012-03-30 Hoffmann La Roche Pochodne oksazolu, sposób ich wytwarzania, środki farmaceutyczne i zastosowanie pochodnych oksazolu
US7192970B2 (en) * 2002-11-26 2007-03-20 Chipscreen Biosciences, Ltd. Noncyclic 1,3-dicarbonyl compounds as dual PPAR agonists with potent antihyperglycemic and antihyperlipidemic activity
WO2004073606A2 (en) 2003-02-14 2004-09-02 Eli Lilly And Company Sulfonamide derivatives as ppar modulators
DE102004060227B3 (de) * 2004-12-15 2006-07-20 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von Oxazolen durch Kondensation von aromatischen Aldehyden mit α-Ketoximen zu N-Oxiden und nachfolgende Reaktion mit aktivierten Säurederivaten
EP1911738A4 (de) * 2005-07-29 2009-12-16 Takeda Pharmaceutical Phenoxyalkansäureverbindung
TWI464164B (zh) * 2009-08-05 2014-12-11 Daiichi Sankyo Co Ltd 醯胺衍生物
CN103249726B (zh) * 2010-10-14 2015-01-07 第一三共株式会社 酰基苯衍生物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089514A (en) 1990-06-14 1992-02-18 Pfizer Inc. 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
US5232945A (en) 1992-07-20 1993-08-03 Pfizer Inc. 3-aryl-2-hydroxypropionic acid derivatives and analogs as antihypertensives
US5902726A (en) 1994-12-23 1999-05-11 Glaxo Wellcome Inc. Activators of the nuclear orphan receptor peroxisome proliferator-activated receptor gamma
ES2202582T3 (es) 1996-02-02 2004-04-01 MERCK & CO., INC. Agentes antidiabeticos.
GB9604242D0 (en) 1996-02-28 1996-05-01 Glaxo Wellcome Inc Chemical compounds
WO1998007699A1 (fr) 1996-08-19 1998-02-26 Japan Tobacco Inc. Derives d'acide propionique et applications de ces derives
ATE451346T1 (de) * 1998-03-10 2009-12-15 Ono Pharmaceutical Co Carbonsäurederivate und medikamente die diese als aktiven wirkstoff enthalten
PT1206457E (pt) 1999-08-27 2004-03-31 Lilly Co Eli Derivados de diaril-oxa(tia)zol e seu uso como moduladores dos ppars
JP4316787B2 (ja) 2000-01-11 2009-08-19 壽製薬株式会社 エーテル又はアミド誘導体、その製法並びにそれを含有する糖尿病治療剤、
JP2004506721A (ja) * 2000-08-23 2004-03-04 イーライ・リリー・アンド・カンパニー オキサゾリル−アリールプロピオン酸誘導体およびそのｐｐａｒアゴニストとしての使用
AU2001284658A1 (en) 2000-08-23 2002-03-13 Eli Lilly And Company Oxazolyl-aryloxyacetic acid derivatives and their use as ppar agonists

Also Published As

Publication number Publication date
AU2001284660A1 (en) 2002-03-04
EP1313717A1 (de) 2003-05-28
WO2002016332A1 (en) 2002-02-28
EP1313717B1 (de) 2007-10-17
JP2004506722A (ja) 2004-03-04
ES2295200T3 (es) 2008-04-16
MXPA03001610A (es) 2003-09-10
DE60131001D1 (de) 2007-11-29
ATE375985T1 (de) 2007-11-15
US20040138277A1 (en) 2004-07-15
US7176224B2 (en) 2007-02-13
DE60131001T2 (de) 2008-07-17

Similar Documents

Publication Publication Date Title
US6825222B2 (en) Modulators of peroxisome proliferator activated receptors
US7351728B2 (en) Oxazolyl-aryloxyacetic acid derivatives and their use as PPAR agonists
US7345070B2 (en) Peroxisome proliferator activated receptor agonists
EP1480640A1 (de) Modulatoren von peroxisome proliferator-aktivierten rezeptoren
CA2418134A1 (en) Oxazolyl-arylpropionic acid derivatives and their use as ppar agonists

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued