CA2411660C - Composes de promedicament a clivage enzymatique - Google Patents
Composes de promedicament a clivage enzymatique Download PDFInfo
- Publication number
- CA2411660C CA2411660C CA2411660A CA2411660A CA2411660C CA 2411660 C CA2411660 C CA 2411660C CA 2411660 A CA2411660 A CA 2411660A CA 2411660 A CA2411660 A CA 2411660A CA 2411660 C CA2411660 C CA 2411660C
- Authority
- CA
- Canada
- Prior art keywords
- seq
- beta
- leu
- ala
- oligopeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Ce promédicament est une forme modifiée d'un agent thérapeutique et comprend un agent thérapeutique, un oligopeptide, un groupe de stabilisation et éventuellement un groupe de liaison. Ce promédicament peut être clivé par la Thimet oligopeptidase, ou TOP. L'invention concerne également des procédés de conception de promédicaments comprenant l'introduction de séquences de clivage par TOP dans le conjugué, ainsi que des traitements comprenant l'administration des promédicaments décrits à des patients.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21188700P | 2000-06-14 | 2000-06-14 | |
US60/211,887 | 2000-06-14 | ||
US29044801P | 2001-05-11 | 2001-05-11 | |
US60/290,448 | 2001-05-11 | ||
PCT/US2001/018903 WO2001095945A2 (fr) | 2000-06-14 | 2001-06-11 | Composes de promedicament a clivage enzymatique |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2411660A1 CA2411660A1 (fr) | 2001-12-20 |
CA2411660C true CA2411660C (fr) | 2011-03-01 |
Family
ID=26906558
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2411660A Expired - Fee Related CA2411660C (fr) | 2000-06-14 | 2001-06-11 | Composes de promedicament a clivage enzymatique |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1294405A2 (fr) |
JP (1) | JP2004510703A (fr) |
AU (2) | AU7130101A (fr) |
CA (1) | CA2411660C (fr) |
WO (1) | WO2001095945A2 (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7129261B2 (en) | 2001-05-31 | 2006-10-31 | Medarex, Inc. | Cytotoxic agents |
EP1404356B1 (fr) * | 2001-06-11 | 2011-04-06 | Medarex, Inc. | Méthode pour concevoir des promédicaments activés par cd10 |
FR2858936A1 (fr) * | 2003-08-22 | 2005-02-25 | Diatos | Potentialisation de l'activation de prodrogues de haut poids moleculaire |
MX2009005776A (es) | 2006-12-01 | 2009-06-10 | Medarex Inc | Anticuerpos humanos que se enlazan al cd 22 y sus usos. |
CL2007003622A1 (es) | 2006-12-13 | 2009-08-07 | Medarex Inc | Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales. |
WO2008074004A2 (fr) | 2006-12-14 | 2008-06-19 | Medarex, Inc. | Anticorps humains se liant à cd70 et utilisations de ceux-ci |
DE102008007381A1 (de) | 2008-02-01 | 2009-08-13 | Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co.Kg | Amidine und Guanidine und deren Derivate zur Behandlung von Krankheiten |
US9662308B2 (en) | 2008-02-01 | 2017-05-30 | Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co. Kg | Orally bioavailable pentamidine prodrugs for the treatment of diseases |
US10087221B2 (en) | 2013-03-21 | 2018-10-02 | Sanofi-Aventis Deutschland Gmbh | Synthesis of hydantoin containing peptide products |
DK2976325T3 (en) | 2013-03-21 | 2017-06-06 | Sanofi Aventis Deutschland | SYNTHESIS OF PEPTIDE PRODUCTS CONTAINING CYCLIC IMID |
CA3203072A1 (fr) | 2020-12-22 | 2022-06-30 | Andrea CASAZZA | Composes comprenant une fraction tetrapeptidique |
WO2022167664A1 (fr) | 2021-02-07 | 2022-08-11 | Cobiores Nv | Composés comprenant une fraction tétrapeptidique |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0769967B1 (fr) * | 1994-08-19 | 2007-12-12 | La Region Wallonne | Conjugues comprenant un agent antitumoral et leur utilisation |
DK1144011T3 (da) * | 1998-12-11 | 2010-07-05 | Coulter Pharm Inc | Pro-drug-forbindelser og fremgangsmåde til fremstilling deraf |
-
2001
- 2001-06-11 EP EP01950291A patent/EP1294405A2/fr not_active Withdrawn
- 2001-06-11 JP JP2002510122A patent/JP2004510703A/ja active Pending
- 2001-06-11 CA CA2411660A patent/CA2411660C/fr not_active Expired - Fee Related
- 2001-06-11 AU AU7130101A patent/AU7130101A/xx active Pending
- 2001-06-11 AU AU2001271301A patent/AU2001271301B2/en not_active Ceased
- 2001-06-11 WO PCT/US2001/018903 patent/WO2001095945A2/fr active Application Filing
Also Published As
Publication number | Publication date |
---|---|
AU7130101A (en) | 2001-12-24 |
AU2001271301B2 (en) | 2006-08-31 |
CA2411660A1 (fr) | 2001-12-20 |
EP1294405A2 (fr) | 2003-03-26 |
JP2004510703A (ja) | 2004-04-08 |
WO2001095945A3 (fr) | 2002-08-15 |
WO2001095945A2 (fr) | 2001-12-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |