CA2407272A1 - Procede et composition permettant d'analyser un polymere glucidique - Google Patents

Procede et composition permettant d'analyser un polymere glucidique Download PDF

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Publication number
CA2407272A1
CA2407272A1 CA002407272A CA2407272A CA2407272A1 CA 2407272 A1 CA2407272 A1 CA 2407272A1 CA 002407272 A CA002407272 A CA 002407272A CA 2407272 A CA2407272 A CA 2407272A CA 2407272 A1 CA2407272 A1 CA 2407272A1
Authority
CA
Canada
Prior art keywords
saccharide
binding agent
binding
carbohydrate polymer
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002407272A
Other languages
English (en)
Inventor
Ofer Markman
Assaf Peretz Oron
Chana Rothman-Schertz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procognia (Israel) Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IL2000/000256 external-priority patent/WO2000068688A1/fr
Application filed by Individual filed Critical Individual
Publication of CA2407272A1 publication Critical patent/CA2407272A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/415—Assays involving biological materials from specific organisms or of a specific nature from plants
    • G01N2333/42—Lectins, e.g. concanavalin, phytohaemagglutinin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/924—Hydrolases (3) acting on glycosyl compounds (3.2)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/02—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates involving antibodies to sugar part of glycoproteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

L'invention concerne un procédé permettant de caractériser un polymère glucidique par identification d'au moins deux agents de liaison se liant au polymère glucidique. De préférence, la liaison est déterminée par mise en contact du polymère glucidique avec un substrat contenant plusieurs premiers agents de liaison à la saccharide fixés à des emplacements prédéterminés sur le substrat. Le polymère glucidique peut ainsi entrer en contact avec le substrat dans des conditions permettant la formation d'un premier complexe entre ledit premier agent de liaison et le polymère glucidique. Un second agent de liaison à la saccharide, comprenant, de préférence, un traceur, est également mis en contact avec le polymère glucidique dans des conditions permettant la formation d'un second complexe entre le second agent de liaison et le premier complexe. L'identification du premier agent de liaison et du second agent de liaison permet de caractériser le polysaccharide.
CA002407272A 2000-05-04 2000-11-03 Procede et composition permettant d'analyser un polymere glucidique Abandoned CA2407272A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/IL2000/000256 WO2000068688A1 (fr) 1999-05-06 2000-05-04 Structure polysaccharidique et determination de la sequence
ILPCT/IL00/00256 2000-05-04
PCT/US2000/030402 WO2001084147A1 (fr) 2000-05-04 2000-11-03 Procede et composition permettant d"analyser un polymere glucidique

Publications (1)

Publication Number Publication Date
CA2407272A1 true CA2407272A1 (fr) 2001-11-08

Family

ID=11042969

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002407272A Abandoned CA2407272A1 (fr) 2000-05-04 2000-11-03 Procede et composition permettant d'analyser un polymere glucidique

Country Status (5)

Country Link
EP (1) EP1281082A1 (fr)
JP (1) JP2004506874A (fr)
AU (1) AU2001217569A1 (fr)
CA (1) CA2407272A1 (fr)
WO (1) WO2001084147A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL129835A (en) 1999-05-06 2008-03-20 Ofer Markman Polysaccharide sequencing and structure determination
EP1402450A2 (fr) * 2000-11-03 2004-03-31 Procognia, Ltd. Systeme et procede destines a l'analyse integree de donnees aux fins de caracterisation de polymeres carbohydrates
US7079955B2 (en) 2000-11-03 2006-07-18 Procognia, Ltd. System and method for integrated analysis of data for characterizing carbohydrate polymers
AU2002362903A1 (en) * 2001-10-16 2003-04-28 Procognia, Ltd. Method of preparing purified biologically active oligosaccharide libraries
DE10249608A1 (de) * 2002-10-18 2004-05-06 Gkss-Forschungszentrum Geesthacht Gmbh Vorrichtung und Verfahren zur Strukturanalyse und Detektion von komplexen Glykostrukturen
CA2548219A1 (fr) 2003-12-18 2005-06-30 Yehudit Amor Procede d'analyse d'une glycomolecule
US20120165206A1 (en) 2006-07-11 2012-06-28 Rakefet Rosenfeld Method and Assay for Glycosylation Pattern Detection Related to Cell State

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI852545L (fi) * 1984-06-29 1985-12-30 Ortho Diagnostic Systems Inc Sandwichanalys av antikroppslektin.
US5100778A (en) * 1989-10-03 1992-03-31 Monsanto Company Oligosaccharide sequencing

Also Published As

Publication number Publication date
EP1281082A1 (fr) 2003-02-05
WO2001084147A1 (fr) 2001-11-08
AU2001217569A1 (en) 2001-11-12
JP2004506874A (ja) 2004-03-04

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued