CA2394033A1 - Ibd-related polymorphisms - Google Patents

Abstract

The invention provides nucleic acid segments of the human genome, particular ly nucleic acid segments from a gene, including polymorphic sites. Allele- specific primers and probes hybridizing to regions flanking or containing these sites are also provided. The nucleic acids, primers and probes are use d in applications such as phenotype correlations, forensics, paternity testing , medicine and genetic analysis.

Description

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IBD-RELATED POLYMORPHISMS
RELATED APPLICATIONS
This application claims the benefit of U.S. Provisional Application Serial No. 60/170,257, filed December 10, 1999, and U.S. Provisional Application Serial No. 60/196,046, filed April 10, 2000, the entire teachings of both of which are incorporated herein by reference in their entirety.
BACKGROUND OF THE 'INVENTION
The genomes of all organisms undergo spontaneous mutation in the course of their continuing evolution, generating variant forms of progenitor nucleic acid sequences (Gusella, Ann. Rev. Biochem. 55, 831-854 (1986)). The variant form may confer an evolutionary advantage or disadvantage relative to a progenitor form, or may be neutral. In some instances, a variant form confers a lethal disadvantage and is not transmitted to subsequent generations of the organism. In other instances, a variant form confers an evolutionary advantage to the species and is eventually incorporated into the DNA of many or most members of the species and effectively becomes the progenitor form. In many instances, both progenitor and variant forms) survive and co-exist in a species population. The coexistence of multiple forms of a sequence gives rise to polymorphisms.

Several different types of polymorphism have been reported. A restriction fragment length polymorphism (RFLP) is a variation in DNA sequence that alters the length of a restriction fragment (Botstein et al., Am. J. Hum. Genet. 32, (1980)). The restriction fragment length polymorphism may create or delete a restriction site, thus changing the length of the restriction fragment. RFLPs have been widely used in human and animal genetic analyses (see WO 90/13668;
W090/11369; Donis-Keller, Cell Sl, 319-337 (1987); Lander et al., Genetics 121, 85-99 (1989)). When a heritable trait can be linked to a particular RFLP, the presence of the RFLP in an individual can be used to predict the likelihood that the animal will also exhibit the trait.
Other polymorphisms take the form of short tandem repeats (STRs) that include tandem di-, tri- and tetra-nucleotide repeated motifs. These tandem repeats are also referred to as variable number tandem repeat (VNTR) polymorphisms.
VNTRs have been used in identity and paternity analysis (US 5,075,217; Armour et al., FEBS Lett. 307, 113-115 (1992); Horn et al., WO 91/14003; Jeffreys, EP
370,719), and in a large number of genetic mapping studies.
Other polymorphisms take the form of single nucleotide variations between individuals of the same species. Such polymorphisms are far more frequent than RFLPs, STRs and VNTRs. Some single nucleotide polymorphisms (SNP) occur in protein-coding nucleic acid sequences (coding sequence SNP (cSNP)), in which case, one of the polymorphic forms may give rise to the expression of a defective or otherwise variant protein and, potentially, a genetic disease. Examples of genes in which polymorphisms within coding sequences give rise to genetic disease include ~i-globin (sickle cell anemia), apoE4 (Alzheimer's Disease), Factor V Leiden (thrombosis), and CFTR (cystic fibrosis). cSNPs can alter the codon sequence of the gene and therefore specify an alternative amino acid. Such changes are called "missense" when another amino acid is substituted, and "nonsense" when the alternative codon specifies a stop signal in protein translation. When the cSNP does not alter the amino acid specified the cSNP is called "silent". Other single nucleotide polymorphisms occur in noncoding regions. Some of these polymorphisms may also result in defective protein expression (e.g., as a result of defective splicing). Other single nucleotide polymorphisms have no phenotypic effects.
Single nucleotide polymorphisms can be used in the same manner as RFLPs and VNTRs, but offer several advantages. Single nucleotide polymorphisms occur with greater frequency and are spaced more uniformly throughout the genome than other forms of polymorphism. The greater frequency and uniformity of single nucleotide polymorphisms means that there is a greater probability that such a polymorphism will be found in close proximity to a genetic locus of interest than would be the case for other polymorphisms. The different forms of characterized single nucleotide polymorphisms are often easier to distinguish than other types of polymorphism (e.g., by use of assays employing allele-specific hybridization probes or primers).
Only a small percentage of the total repository of polymorphisms in humans and other organisms has been identified. The limited number of polymorphisms identified to date is due to the large amount of work required for their detection by conventional methods. For example, a conventional approach to identifying polymorphisms might be to sequence the same stretch of DNA in a population of individuals by dideoxy sequencing. In this type of approach, the amount of work increases in proportion to both the length of sequence and the number of individuals in a population and becomes impractical for large stretches of DNA or large numbers of persons.
SUMMARY OF THE INVENTION
Work described herein pertains to the identification of polymorphisms which are associated with inflammatory bowel diseases (IBD), and particularly those within a single risk haplotype, by resequencing large numbers of genes and gene fragments in a large number of individuals. Various genes from a number of individuals have been resequenced as described herein, and SNPs in these genes have been discovered (see Table 3). Some of these SNPs are cSNPs which specify a different amino acid sequence, some of the SNPs are silent cSNPs and some of these cSNPs specify a stop signal in protein translation. Some of the identified SNPs were located in non-coding regions.

With the goal of identifying IBD susceptibility genes, a genomewide scan was undertaken in 163 pedigrees, and three regions of suggestive linkage (3, Sq31-33, 6p) and one of'significant linkage to 19p13 (LOD = 4.6) were identified.
Higher density mapping in the suggestive Sq31-33 region revealed a CD susceptibility locus of genome-wide significance (LOD = 3.9). Importantly, the Sq31-p33 localizes to the maj or immunoregulatory cytokine gene cluster and the 19p 13 locus to a region containing numerous genes encoding cytokine/chemokine receptors and other inflammatory-associated molecules that could have a direct role in disease susceptibility.
In order to pursue the evidence of linkage to chromosome S, a systematic linkage disequilibrium (LD) approach was adopted. The approach that was used in the first stage of LD mapping was to genotype all known microsatellite markers in the 18 cM between DSS1435 and DSS1480, as these two markers delimit a region of a 2 LOD drop on either side of the linkage peak centered at marker DSS2497.
All alleles for each marker were examined for evidence of excess transmission from heterozygous parents to CD child using the transmission disequilibrium test (TDT).
Only alleles at two of the 57 markers had significant CZ results (p<0.001 ):
IRF 1p 1 (CZ=13.3, p=0.0003) and DSS1984 (CZ=14.0, p=0.0002) (Table 1). A second stage of mapping was then undertaken to confirm, as well as to better delimit, the region of LD surrounding IRFlpland DSS1984. The development of new microsatellite markers was necessary. The marker with the most significant CZ result was CAhl7a (CZ=16.2, p=0.00006) and was located between IRFlpland DSS1984 (Table 2).
Furthermore, the alleles 193, 156, 373, 140, 222, and 307 at markers GAhl8a, IRFIp, CAhlSa, CAhl7a, DSS1984, CSF2p10, respectively, define a haplotype conferring susceptibility to Crohn's disease (CD). In order to identify the sequence variant that would explain the genetic susceptibility to CD provided by this haplotype, a search was performed for all single nucleotide polymorphisms (SNPs) in this region of LD. The SNP discovery was accomplished by direct sequencing of overlapping PCR products amplified from DNA samples from eight individuals (six CD patients, one unaffected family member, and one CEPH DNA as control). Table 3 shows the results of the SNP discovery analyses.

139 triads were genotyped for a total of 241 SNPs thus far, where at least 50 trios were fully genotyped. Using a CZ value of 13 (corresponding to a p-value of 0.05) as threshold, 12 SNPs were found to have a significant level of association with CD and extended over a region of 250 kb, from IRF 1 to prolyl4 hydroxylase.
These were markers IGR2055a 1, IGR2060a 1, IGR2063b_1, IGR2069a 2, IGR2078a 1, IGR2096a 1, IGR2198a 1, IGR2230a 1, IGR2277a l, IGR3081a l, IGR3096a 1, PROLYLex3_1 (see Table 4). Any of these best SNPs by themselves are in strong association with CD and fully explain the microsatellite LD
observations. Furthermore, the best SNPs have nearly identical association characteristics (that is, the allele at one SNP determines the allele of all others on any phased chromosome), confirming that a single risk haplotype extending approximately 250 kb is the source of all the observations of association in this region. Specifically, this haplotype is defined by the alleles G, C, G, T, A, A, G, T, G, G, C, T at markers IGR2055a 1, IGR2060a 1, IGR2063b-1, IGR2069a 2, IGR2078a 1, IGR2096a 1, IGR2198a 1, IGR2230a 1, IGR2277a 1, IGR3081a 1, IGR3096a 1, PROLYLex3-1, respectively. The frequency of this haplotype is estimated to be approximately 37% in the general population. Furthermore, this haplotype is transmitted from heterozygous parents to CD patients at a ratio of 2.5:1.
The invention relates to a isolated gene or nucleic acid molecule which comprises a single nucleotide polymorphism at a specific location. In a particular embodiment the invention relates to the variant allele of a gene having a single nucleotide polymorphism, which variant allele differs from a reference allele by one nucleotide at the sites) identified in Table 3. Complements of these nucleic acid segments are also included. The segments can be DNA or RNA, and can be double-or single-stranded. Segments can be, for example, 5-10, 5-15, 10-20, 5-25, 10-30, 10-50 or 10-100 bases long.
The invention further provides allele-specific oligonucleotides that hybridize to a gene comprising a single nucleotide polymorphism or to the complement of the gene. These oligonucleotides can be probes or primers.
The invention further provides a method of analyzing a nucleic acid from an individual. The method determines which base is present at any one of the polymorphic sites shown in Table 3. Optionally, a set of bases occupying a set of the polymorphic sites shown in Table 3 is determined. This type of analysis can be performed on a number of individuals, who are tested for the presence of a disease phenotype. The presence or absence of disease phenotype is then correlated with a base or set of bases present at the polymorphic site or sites in the individuals tested.
Thus, the invention further relates to a method of predicting the presence, absence, likelihood of the presence or absence, or severity of a particular phenotype or disorder associated with a particular genotype. The method comprises obtaining a nucleic acid sample from an individual and determining the identity of one or more bases (nucleotides) at polymorphic sites of genes described herein, wherein the presence of a particular base is correlated with a specified phenotype or disorder, thereby predicting the presence, absence, likelihood of the presence or absence, or severity of the phenotype or disorder in the individual. In one embodiment of the invention, the phenotype is inflammatory bowel disease or Crohn's disease.
BRIEF DESCRIPTION OF THE DRAWING
1 S The Figure shows multipoint nonparametric linkage results for the IBD
genome scan. Multipoint LOD scores were calculated using the MAPMAKER/SIBS functions implemented in GENHUNTER 2Ø The thick black line indicates the LOD score along the length of each chromosome, and the tick marks indicate the position of the microsatellite markers. The two horizontal lines depict the genome-wide thresholds for suggestive (LOD = 2.0) and significant linkage.
DETAILED DESCRIPTION OF THE INVENTION
Crohn's disease (CD) and ulcerative colitis (UC) are chronic, idiopathic inflammatory disorders of the gastrointestinal tract. These inflammatory bowel diseases (IBD) have a peak incidence in early adulthood, and their combined prevalence is approximately 100-200/100,000. The inflammation in IBD is characterized by altered expression of both pro-inflammatory and immunoregulatory cytokines in the affected intestinal mucosa (Kmiec, Arch Immunol Ther Expe (Warsz) 46(3):143-155 (1998)). Genetic factors are believed to play an important role, as the sibling risk (~,S) calculated for IBD ranges from 1 S-40, with a stronger _7_ genetic contribution occurring for CD (~,5~ 35) as compared to UC (~,S ~ 15).
Additionally, relatives of individuals with IBD diagnosed at younger ages appear to be at an even higher risk.
CD is characterized by discontinuous, transmural inflammation affecting any part of the gastrointestinal tract and is manifested by abdominal pain, chronic diarrhea, weight loss, bowel obstructions and fistulae. UC occurs as a continuous, mucosal inflammation affecting only the large intestine with primary symptoms including diarrhea, rectal bleeding and abdominal pain. The search for susceptibility genes for these two diseases has resulted in the identification of two potential susceptibility loci. The first, called IBDI, is a CD-susceptibility locus that lies in the pericentromeric region of chromosome 16 (Hugo et al., Nature 379:821-822 (1996)). The second (IBD2) is located in a 41 cM region surrounding marker D12S83 and appears to be linked to both CD and UC (Satsangi et al., Genetics 14:199-202 (1996)). These putative loci, however, have only been replicated in some, but not all, subsequent studies (Cavanaugh et al., Proc Natl Acad Sci USA
62:291-298 (1998); Cho et al., The National Academy of Sciences 95:7502-7507 (1998); Curren et al., Gastroenterology 115:1-7 (1998); Duerr et al., The American Society of Human Genetics 63:95-100 (1998); Rioux et al., Am. J. Hum. Genet.
63:1086-1094 (1998); Yang et al., Gastroenterology 109:440-448 (1995)), supporting the belief that there exists substantial genetic heterogeneity.
Furthermore, IBDI and IBD2 only account for a fraction of the heritability of IBD, suggesting that additional loci contribute to disease susceptibility. Thus, as described herein, the susceptibility loci in a Canadian IBD population was assessed by studying families with multiple affected siblings (McLeod et al., Dis Colon Rectum 40:553-557 (1997)).
A genome-wide screen was performed on 181 IBD-affected sibling pairs (ASP) and 5 IBD-affected relative pairs (RP) from 163 families. Among these ASP, 122 were CD pairs, .25 were UC pairs, and 34 were "mixed" pairs (one sibling with either CD or UC, the other with CD, UC or IC). All ASP and available parents (140 families had both parents available, 17 had one parent available, and 1 was missing both parents), as well as all RP, were genotyped with 312 microsatellite markers covering the genome with approximately 12 cM distance between markers.

_g_ Simulations of this dataset indicated that the genome-wide threshold for suggestive linkage (the score expected to occur one time at random in a genome scan) was at a LOD of 2Ø Using either this calculated threshold, or the published threshold of LOD 2.2 based on an infinitely dense map (Lander & Kruglyak, Nature Genetics 11:241-247 (1995)), multipoint nonparametric linkage analysis of these data revealed 4 loci which surpassed this threshold (Figure). Specifically, chromosome 3 had a peak LOD of 2.4 between markers D3 S 1766 and D#S 1285, chromosome 5 a peak LOD of 3.0 between GATA68A03 and DSS816, chromosome 6 a peak LOD of 2.3 between D6S 1019 and D6S 1017, and chromosome 19 a peak LOD of 4.6 between GATA21G05 and D19S586. In fact this chromosome 19 locus exceeds the threshold for genome-wide significance of 3.6 (Lander & Kruglyak, Nature Genetics 11:241-247 (1995)), and represents a novel IBD susceptibility locus.
This novel locus maps to an extended region on 19p 13 (Figure) that contains many different genes of immunologic interest such as intercellular adhesion molecule 1 (ICAM1), complement component 3 (C3), the thromboxane A2 receptor (TBXA2), leukotriene B4 hydroxylase (LTB4H), and the janus tyrosine kinases TYK2 and JAK3. There is some evidence supporting their relevance in IBD
susceptibility: 1) modest positive association results have been reported for the ICAM1 (Yang et al., Gastroenterology 109:440-448 (1995)) and C3 molecules (Elmgreen et al., Acta Med Scand 215(4):375-8 (1984)); 2) attempts to interfere with the TBXA2 (Taniguchi, 1997) and LTB4 (Hawkey et al., Agents Actions, Special Conference Issue (1992)) mediated inflammatory pathways have shown some therapeutic value; and 3) the janus kinases have been shown to be important in the transduction of the molecular signal from cytokine receptors.
The finding of suggestive linkage to an approximately 30 cM region spanning the cytokine gene cluster on Sq31-q33, containing many of the immunoregulatory cytokines such as IL4, IL13, ILS and IL3, led to the performance of higher density mapping in this region. Specifically, the original families and an additional families were genotyped for 34 extra microsatellite markers. Multipoint nonparametric analysis were then performed using three different phenotypic categories: IBD, CD and CD 16. In the first, all individuals with CD, UC or IC
were designated as affected; in the second, only individuals with CD were designated as _9_ affected; in the third, only individuals with CD were designated as affected and only families with at least one affected sibling diagnosed at the age of 16 or younger were included. This last category was examined due to an expected enrichment for genetic factors over environmental causes. These analyses demonstrate the presence S of a locus of genome-wide significance in the group with early onset CD (MLS
=
3.9). Evidence for linkage to the syntenic region in mice has been reported in an induced model of colitis (Mahler, Genomics 55:147-156 (1999)).
Although the suggestive loci on chromosomes 3 and 6 identified as described herein have not yet been followed up with higher density mapping, it is important to note that the linkage peak on chromosome 3 is approximately 10 cM away from a previously reported suggestive locus (Satsangi et al., Nature Genetics 14:199-(1996)), and the linkage peak on 6 lies approximately 20 cM centromeric to the major histocompatibility complex (MHC) Class II region. A recent study has described linkage to this chromosome 6 region (Hampe et al., Am. J. Hum.
Genet.
64 (1999)), and a large meta-analysis of the results derived from 29 different studies has also reported that both CD and UC were associated with specific Class II
alleles (Stokkers et al., Gut 45:395-401 (1999)). Finally, in order to assess whether the IBDI and IBD2 loci are contributing to the IBD susceptibility in this population, exclusion mapping of the data was performed. These analyses demonstrate that the entire chromosome 12 can be excluded for loci of even modest effects (~,S >
1.5), but can only loci conferring a ~,S > 4 on chromosome 16 can be excluded, suggesting that IBD1 (~,S ~ 1.3) could have gone undetected in the present study.
Thus, this work has identified two novel susceptibility loci: a locus on chromosome Sq31-33 that confers susceptibility to CD and a locus on chromosome 19p13 that confers susceptibility to IBD. Furthermore, particular SNPs within these loci have been identified which may be associated with disease susceptibility.
The present invention relates to a gene which comprises a single nucleotide polymorphism (SNP) at a specific location. The gene which includes the SNP has at least two alleles, referred to herein as the reference allele and the variant allele. The reference allele (prototypical or wild type allele) has been designated arbitrarily and typically corresponds to the nucleotide sequence of the gene which has been deposited with GenBank or TIGR under a given Accession number. The variant allele differs from the reference allele by one nucleotide at the sites) identified in Table 3. The present invention also relates to variant alleles of the described genes and to complements of the variant alleles. The invention further relates to portions of the variant alleles and portions of complements of the variant alleles which comprise (encompass) the site of the SNP and are at least 5 nucleotides in length.
Portions can be, for example, 5-10, 5-15, 10-20, 5-25, 10-30, 10-50 or 10-100 bases long. For example, a portion of a variant allele which is 21 nucleotides in length includes the single nucleotide polymorphism (the nucleotide which differs from the reference allele at that site) and twenty additional nucleotides which flank the site in the variant allele. These nucleotides can be on one or both sides of the polymorphism.
Polymorphisms which are the subject of this invention are defined in Table 3.
The reference sequence for many of the genes or gene fragments is provided in Table 5. For sequences which are not present in Table 5, the skilled artisan can readily determine the specific location of the polymorphism given the 3' and 5' nucleotide sequence flanking the polymorphic site provided in Table 3 and the chromosomal loci information provided herein. The nucleotide sequences of the invention can be double- or single-stranded.
The invention further provides allele-specific oligonucleotides that hybridize to a gene comprising a single nucleotide polymorphism or to the complement of the gene. These oligonucleotides can be probes or primers.
The invention further provides a method of analyzing a nucleic acid from an individual. The method determines which base is present at any one of the polymorphic sites shown in Table 3. Optionally, a set of bases occupying a set of the polymorphic sites shown in Table 3 is determined. This type of analysis can be performed on a number of individuals, who are tested for the presence of a disease phenotype. The presence or absence of disease phenotype is then correlated with a base or set of bases present at the polymorphic site or sites in the individuals tested.
Thus, the invention further relates to a method of predicting the presence, absence, likelihood of the presence or absence, or severity of a particular phenotype or disorder associated with a particular genotype. The method comprises obtaining a nucleic acid sample from an individual and determining the identity of one or more bases (nucleotides) at polymorphic sites of genes described herein, wherein the presence of a particular base is correlated with a specified phenotype or disorder, thereby predicting the presence, absence, likelihood of the presence or absence, or severity of the phenotype or disorder in the individual.
DEFINITIONS
An oligonucleotide can be DNA or RNA, and single- or double-stranded.
Oligonucleotides can be naturally occurring or synthetic, but are typically prepared by synthetic means. Preferred oligonucleotides of the invention include segments of DNA, or their complements, which include any one of the polymorphic sites shown in Table 3. The segments can be between 5 and 250 bases, and, in specific embodiments, are between 5-10, 5-20, 10-20, 10-50, 20-50 or 10-100 bases. For example, the segment can be 21 bases. The polymorphic site can occur within any position of the segment. The segments can be from any of the allelic forms of DNA
shown in Table 3.
As used herein, the terms "nucleotide", "base" and "nucleic acid" are intended to be equivalent. The terms "nucleotide sequence", "nucleic acid sequence", "nucleic acid molecule" and "segment" are intended to be equivalent.
Hybridization probes are oligonucleotides which bind in a base-specific manner to a complementary strand of nucleic acid. Such probes include peptide nucleic acids, as described in Nielsen et al., Science 254, 1497-1500 (1991).
Probes can be any length suitable for specific hybridization to the target nucleic acid sequence. The most appropriate length of the probe may. vary depending upon the hybridization method in which it is being used; for example, particular lengths may be more appropriate for use in microfabricated arrays, while other lengths may be more suitable for use in classical hybridization methods. Such optimizations are known to the skilled artisan. Suitable probes and primers can range from about nucleotides to about 30 nucleotides in length. For example, probes and primers can be 5, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 25, 26, 28 or 30 nucleotides in length. The probe or primer preferably overlaps at least one polymorphic site occupied by any of the possible variant nucleotides. The nucleotide sequence can correspond to the coding sequence of the allele or to the complement of the coding sequence of the allele.
As used herein, the term "primer" refers to a single-stranded oligonucleotide which acts as a point of initiation of template-directed DNA synthesis under appropriate conditions (e.g., in the presence of four different nucleoside triphosphates and an agent for polymerization, such as DNA or RNA polymerase or reverse transcriptase) in an appropriate buffer and at a suitable temperature.
The appropriate length of a primer depends on the intended use of the primer, but typically ranges from 15 to 30 nucleotides. Short primer molecules generally require cooler temperatures to form sufficiently stable hybrid complexes with the template. A primer need not reflect the exact sequence of the template, but must be sufficiently complementary to hybridize with a template. The term primer site refers to the area of the target DNA to which a primer hybridizes. The term primer pair refers to a set of primers including a 5' (upstream) primer that hybridizes with the S' end of the DNA sequence to be amplified and a 3' (downstream) primer that hybridizes with the complement of the 3' end of the sequence to be amplified.
As used herein, linkage describes the tendency of genes, alleles, loci or genetic markers to be inherited together as a result of their location on the same chromosome. It can be measured by percent recombination between the two genes, alleles, loci or genetic markers.
As used herein, polymorphism refers to the occurrence of two or more genetically determined alternative sequences or alleles in a population. A
polymorphic marker or site is the locus at which divergence occurs. Preferred markers have at least two alleles, each occurring at frequency of greater than 1 %, and more preferably greater than 10% or 20% of a selected population. A
polymorphic locus may be as small as one base pair. Polymorphic markers include restriction fragment length polymorphisms, variable number of tandem repeats (VNTR's), hypervariable regions, minisatellites, dinucleotide repeats, trinucleotide repeats, tetranucleotide repeats, simple sequence repeats, and insertion elements such as Alu. The first identified allelic form is arbitrarily designated as the reference form and other allelic forms are designated as alternative or variant alleles.
The allelic form occurnng most frequently in a selected population is sometimes referred to as the wildtype form. Diploid organisms may be homozygous or heterozygous for allelic forms. A diallelic or biallelic polymorphism has two forms. A
triallelic polymorphism has three forms.
Work described herein pertains to the resequencing of large numbers of genes in a large number of individuals to identify polymorphisms which can predispose individuals to disease, particularly IBD.
By altering amino acid sequence, SNPs may alter the function of the encoded proteins. The discovery of the SNP facilitates biochemical analysis of the variants and the development of assays to characterize the variants and to screen for pharmaceutical that would interact directly with on or another form of the protein.
SNPs (including silent SNPs) may also alter the regulation of the gene at the transcriptional or post-transcriptional level. SNPs (including silent SNPs) also enable the development of specific DNA, RNA, or protein-based diagnostics that detect the presence or absence of the polymorphism in particular conditions.
- A single nucleotide polymorphism occurs at a polymorphic site occupied by a single nucleotide, which is the site of variation between allelic sequences.
The site is usually preceded by and followed by highly conserved sequences of the allele (e.g., sequences that vary in less than 1/100 or 1/1000 members of the populations).
A single nucleotide polymorphism usually arises due to substitution of one nucleotide for another at the polymorphic site. A transition is the replacement of one purine by another purine or one pyrimidine by another pyrimidine. A
transversion is the replacement of a purine by a pyrimidine or vice versa.
Single nucleotide polymorphisms can also arise from a deletion of a nucleotide or an insertion of a nucleotide relative to a reference allele. Typically the polymorphic site is occupied by a base other than the reference base. For example, where the reference allele contains the base "T" at the polymorphic site, the altered allele can contain a "C", "G" or "A" at the polymorphic site.
Hybridizations are usually performed under stringent conditions, for example, at a salt concentration of no more than 1 M and a temperature of at least 25°C. For example, conditions of SX SSPE (750 mM NaCI, 50 mM NaPhosphate, 5 mM
EDTA, pH 7.4) and a temperature of 25-30°C, or equivalent conditions, are suitable for allele-specific probe hybridizations. Equivalent conditions can be determined by varying one or more of the parameters given as an example, as known in the art, while maintaining a similar degree of identity or similarity between the target nucleotide sequence and the primer or probe used.
The term "isolated" is used herein to indicate that the material in question exists in a physical milieu distinct from that in which it occurs in nature.
For example, an isolated nucleic acid of the invention may be substantially isolated with respect to the complex cellular milieu in which it naturally occurs. In some instances, the isolated material will form part of a composition (for example, a crude extract containing other substances), buffer system or reagent mix. In other circumstance, the material may be purified to essential homogeneity, for example as determined by PAGE or column chromatography such as HPLC. Preferably, an isolated nucleic acid comprises at least about S0, 80 or 90 percent (on a molar basis) of all macromolecular species present.
I. Novel Polymorphisms of the Invention The novel polymorphisms of the invention are shown in Table 3.
II. Analysis of Polymorphisms A. Preparation of Samples Polymorphisms are detected in a target nucleic acid from an individual being analyzed. For assay of genomic DNA, virtually any biological sample (other than pure red blood cells) is suitable. For example, convenient tissue samples include whole blood, semen, saliva, tears, urine, fecal material, sweat, buccal, skin and hair.
For assay of cDNA or mRNA, the tissue sample must be obtained from an organ in which the target nucleic acid is expressed. For example, if the target nucleic acid is a cytochrome P450, the liver is a suitable source.
Many of the methods described below require amplification of DNA from target samples. This can be accomplished by e.g., PCR. See generally PCR
Technology: Principles and Applications for DNA Amplification (ed. H.A.
Erlich, Freeman Press, NY, NY, 1992); PCR Protocols: A Guide to Methods and Applications (eds. Innis, et al., Academic Press, San Diego, CA, 1990); Manila et al., Nucleic Acids Res. 19, 4967 (1991 ); Eckert et al., PCR Methods and Applications 1, 17 (1991); PCR (eds. McPherson et al., IRL Press, Oxford); and U.S. Patent 4,683,202.
Other suitable amplification methods include the ligase chain reaction (LCR) (see Wu and Wallace, Genomics 4, 560 (1989), Landegren et al., Science 241, (1988), transcription amplification (Kwoh et al., Proc. Natl. Acad. Sci. USA
86, 1173 (1989)), and self sustained sequence replication (Guatelli et al., Proc.
Nat.
Acad. Sci. USA, 87, 1874 (1990)) and nucleic acid based sequence amplification (NASBA). The latter two amplification methods involve isothermal reactions based on isothermal transcription, which produce both single stranded RNA (ssRNA) and double stranded DNA (dsDNA) as the amplification products in a ratio of about or 100 to 1, respectively.
B. Detection of Polymorphisms in Target DNA
The polymorphisms identified as described herein can be used as a platform for genotyping (i.e., determining the genotype of) individuals. This analysis determines which forms) of a characterized (known) polymorphism are present in individuals under test. There are a variety of suitable procedures, which are discussed in turn.
1. Allele-Specific Probes The design and use of allele-specific probes for analyzing polymorphisms is described by e.g., Saiki et al., Nature 324, 163-166 (1986); Dattagupta, EP
235,726, Saiki, WO 89/11548. Allele-specific probes can be designed that hybridize to a segment of target DNA from one individual but do not hybridize to the corresponding segment from another individual due to the presence of different polymorphic forms in the respective segments from the two individuals.
Hybridization conditions should be sufficiently stringent that there is a significant difference in hybridization intensity between alleles, and preferably an essentially binary response, whereby a probe hybridizes to only one of the alleles. Some probes are designed to hybridize to a segment of target DNA such that the polymorphic site aligns with a central position (e.g., in a 15-mer at the 7 position; in a 16-mer, at either the 8 or 9 position) of the probe. This design of probe achieves good discrimination in hybridization between different allelic forms.
Allele-specific probes are often used in pairs, one member of a pair showing a perfect match to a reference form of a target sequence and the other member showing a perfect match to a variant form. Several pairs of probes can then be immobilized on the same support for simultaneous analysis of multiple polymorphisms within the same target sequence.
2. Tiling Arrays The polymorphisms can also be identified by hybridization to nucleic acid arrays, some examples of which are described in WO 95/11995. One form of such arrays is described in the Examples section in connection with de novo identification of polymorphisms. The same array or a different array can be used for analysis of characterized polymorphisms. WO 95/11995 also describes subarrays that are optimized for detection of a variant form of a precharacterized polymorphism.
Such 1 S a subarray contains probes designed to be complementary to a second reference sequence, which is an allelic variant of the first reference sequence. The second group of probes is designed by the same principles as described in the Examples, except that the probes exhibit complementarity to the second reference sequence.
The inclusion of a second group (or further groups) can be particularly useful for analyzing short subsequences of the primary reference sequence in which multiple mutations are expected to occur within a short distance commensurate with the length of the probes (e.g., two or more mutations within 9 to 21 bases).
3. Allele-Specific Primers An allele-specific primer hybridizes to a site on target DNA overlapping a polymorphism and only primes amplification of an allelic form to which the primer exhibits perfect complementarity. See Gibbs, Nucleic Acid Res. 17, 2427-2448 (1989). This primer is used in conjunction with a second primer which hybridizes at a distal site. Amplification proceeds from the two primers, resulting in a detectable product which indicates the particular allelic form is present. A control is usually performed with a second pair of primers, one of which shows a single base mismatch at the polymorphic site and the other of which exhibits perfect complementarity to a distal site. The single-base mismatch prevents amplification and no detectable product is formed. The method works best when the mismatch is included in the 3'-most position of the oligonucleotide aligned with the polymorphism because this position is most destabilizing to elongation from the primer (see, e.g., WO 93/22456).
4. Direct-Sequencing The direct analysis of the sequence of polymorphisms of the present invention can be accomplished using either the dideoxy chain termination method or the Maxam Gilbert method (see Sambrook et al., Molecular Cloning, A Laboratory Manual (2nd Ed., CSHP, New York 1989); Zyskind et al., Recombinant DNA
Laboratory Manual, (Acad. Press, 1988)).
5. Denaturing Gradient Gel Electrophoresis Amplification products generated using the polymerase chain reaction can be analyzed by the use of denaturing gradient gel electrophoresis. Different alleles can be identified based on the different sequence-dependent melting properties and electrophoretic migration of DNA in solution. Erlich, ed., PCR Technology, Principles and Applications for DNA Amplification, (W.H. Freeman and Co, New York, 1992), Chapter 7.
6. Single-Strand Conformation Polymorphism Analysis Alleles of target sequences can be differentiated using single-strand conformation polymorphism analysis, which identifies base differences by alteration in electrophoretic migration of single stranded PCR products, as described in Orita et al., Proc. Nat. Acad. Sci. 86, 2766-2770 (1989). Amplified PCR products can be generated as described above, and~heated or otherwise denatured, to form single stranded amplification products. Single-stranded nucleic acids may refold or form secondary structures which are partially dependent on the base sequence. The different electrophoretic mobilities of single-stranded amplification products can be related to base-sequence differences between alleles of target sequences.

7. Single Base Extension An alternative method for identifying and analyzing polymorphisms is based on single-base extension (SBE) of a fluorescently-labeled primer coupled with fluorescence resonance energy transfer (FRET) between the label of the added base and the label of the primer. Typically, the method, such as that described by Chen et al., (PNAS 94:10756-61 (1997), incorporated herein by reference) uses a locus-specific oligonucleotide primer labeled on the 5' terminus with 5-carboxyfluorescein (FAM). This labeled primer is designed so that the 3' end is immediately adjacent to the polymorphic site of interest. The labeled primer is hybridized to the locus, and single base extension of the labeled primer is performed with fluorescently labeled dideoxyribonucleotides (ddNTPs) in dye-terminator sequencing fashion, except that no deoxyribonucleotides are present. An increase in fluorescence of the added ddNTP in response to excitation at the wavelength of the labeled primer is used to infer the identity of the added nucleotide.
III. Methods of Use After determining polymorphic forms) present in an individual at one or more polymorphic sites, this information can be used in a number of methods.
A. Forensics Determination of which polymorphic forms occupy a set of polymorphic sites in an individual identifies a set of polymorphic forms that distinguishes the individual. See generally National Research Council, The Evaluation of Forensic DNA Evidence (Eds. Pollard et al., National Academy Press, DC, 1996). The more sites that are analyzed, the lower the probability that the set of polymorphic forms in one individual is the same as that in an unrelated individual. Preferably, if multiple sites are analyzed, the sites are unlinked. Thus, polymorphisms of the invention are often used in conjunction with polymorphisms in distal genes. Preferred polymorphisms for use in forensics are biallelic because the population frequencies of two polymorphic forms can usually be determined with greater accuracy than those of multiple polymorphic forms at multi-allelic loci.

The capacity to identify a distinguishing or unique set of forensic markers in an individual is useful for forensic analysis. For example, one can determine whether a blood sample from a suspect matches a blood or other tissue sample from a crime scene by determining whether the set of polymorphic forms occupying selected polymorphic sites is the same in the suspect and the sample. If the set of polymorphic markers does not match between a suspect and a sample, it can be concluded (barring experimental error) that the suspect was not the source of the sample. If the set of markers does match, one can conclude that the DNA from the suspect is consistent with that found at the crime scene. If frequencies of the polymorphic forms at the loci tested have been determined (e.g., by analysis of a suitable population of individuals), one can perform a statistical analysis to determine the probability that a match of suspect and crime scene sample would occur by chance.
p(ID) is the probability that two random individuals have the same polymorphic or allelic form at a given polymorphic site. In biallelic loci, four genotypes are possible: AA, AB, BA, and BB. If alleles A and B occur in a haploid genome of the organism with frequencies x and y, the probability of each genotype in a diploid organism is (see WO 95/12607):
Homozygote: p(AA)= x2 Homozygote: p(BB)= y2 = (1-x)z Single Heterozygote: p(AB)= p(BA)= xy = x(1-x) Both Heterozygotes: p(AB+BA)= 2xy = 2x(1-x) The probability of identity at one locus (i.e, the probability that two individuals, picked at random from a population will have identical polymorphic forms at a given locus) is given by the equation:
p(ID) _ (xz)Z + (2xy)2 + (~)Z.
These calculations can be extended for any number of polymorphic forms at a given locus. For example, the probability of identity p(ID) for a 3-allele system where the alleles have the frequencies in the population of x, y and z, respectively, is equal to the sum of the squares of the genotype frequencies:
p(ID) = x4 + (2xy)2 + (2yz)Z + (2xz)Z + z4 + ya In a locus of n alleles, the appropriate binomial expansion is used to calculate p(ID) and p(exc).
The cumulative probability of identity (cum p(ID)) for each of multiple unlinked loci is determined by multiplying the probabilities provided by each locus.
S cum p(ID) = p(ID1)p(ID2)p(ID3).... p(IDn) The cumulative probability of non-identity for n loci (i.e. the probability that two random individuals will be different at 1 or more loci) is given by the equation:
cum p(nonID) = 1-cum p(ID).
If several polymorphic loci are tested, the cumulative probability of non-identity for random individuals becomes very high (e.g., one billion to one).
Such probabilities can be taken into account together with other evidence in determining the guilt or innocence of the suspect.
B. Paternity Testing The object of paternity testing is usually to determine whether a male is the father of a child. In most cases, the mother of the child is known and thus, the mother's contribution to the child's genotype can be traced. Paternity testing investigates whether the part of the child's genotype not attributable to the mother is consistent with that of the putative father. Paternity testing can be performed by analyzing sets of polymorphisms in the putative father and the child.
If the set of polymorphisms in the child attributable to the father does not match the set of polymorphisms of the putative father, it can be concluded, barring experimental error, that the putative father is not the real father. If the set of polymorphisms in the child attributable to the father does match the set of polymorphisms of the putative father, a statistical calculation can be performed to determine the probability of coincidental match.
The probability of parentage exclusion (representing the probability that a random male will have a polymorphic form at a given polymorphic site that makes him incompatible as the father) is given by the equation (see WO 95/12607):
p(exc) = xy(1-xy) where x and y are the population frequencies of alleles A and B of a biallelic polymorphic site.

(At a triallelic site p(exc) = xy(1-xy) + yz(1- yz) + xz(1-xz)+ 3xyz(1-xyz))), where x, y and z and the respective population frequencies of alleles A, B and C).
The probability of non-exclusion is p(non-exc) = 1-p(exc) The cumulative probability of non-exclusion (representing the value obtained when n loci are used) is thus:
cum p(non-exc) = p(non-excl)p(non-exc2)p(non-exc3).... p(non-excn) The cumulative probability of exclusion for n loci (representing the probability that a random male will be excluded) cum p(exc) = 1 - cum p(non-exc).
If several polymorphic loci are included in the analysis, the cumulative probability of exclusion of a random male is very high. This probability can be taken into account in assessing the liability of a putative father whose polymorphic marker set matches the child's polymorphic marker set attributable to his/her father.
C. Correlation of Polymorphisms with Phenotypic Traits The polymorphisms of the invention may contribute to the phenotype of an organism in different ways. Some polymorphisms occur within a protein coding sequence and contribute to phenotype by affecting protein structure. The effect may be neutral, beneficial or detrimental, or both beneficial and detrimental, depending on the circumstances. For example, a heterozygous sickle cell mutation confers , resistance to malaria, but a homozygous sickle cell mutation is usually lethal. Other polymorphisms occur in noncoding regions but may exert phenotypic effects indirectly via influence on replication, transcription, and translation. A
single polymorphism may affect more than one phenotypic trait. Likewise, a single phenotypic trait may be affected by polymorphisms in different genes. Further, some polymorphisms predispose an individual to a distinct mutation that is causally related to a certain phenotype. For example, the polymorphisms identified herein and shown in Table 3 are present in the chromosomal loci which have been identified as described herein as confernng susceptibility to IBD such as CD
and UC.

Correlation is performed for a population of individuals who have been tested for the presence or absence of a phenotypic trait of interest and for polymorphic markers sets. To perform such analysis, the presence or absence of a set of polymorphisms (i.e. a polymorphic set) is determined for a set of the individuals, some of whom exhibit a particular trait, and some of which exhibit lack of the trait.
The alleles of each polymorphism of the set are then reviewed to determine whether the presence or absence of a particular allele is associated with the trait of interest.
Correlation can be performed by standard statistical methods such as a K-squared test and statistically significant correlations between polymorphic forms) and phenotypic characteristics are noted. For example, it might be found that the presence of allele A1 at polymorphism A correlates with heart disease. As a further example, it might be found that the combined presence of allele Al at polymorphism A and allele B 1 at polymorphism B correlates with increased susceptibility to IBD
(e.g., CD andUC).0 Such correlations can be exploited in several ways. In the case of a strong correlation between a set of one or more polymorphic forms and a disease for which treatment is available, detection of the polymorphic form set in a human or animal patient may justify immediate administration of treatment, or at least the institution of regular monitoring of the patient. Detection of a polymorphic form correlated with serious disease in a couple contemplating a family may also be valuable to the couple in their reproductive decisions. For example, the female partner might elect to undergo in vitro fertilization to avoid the possibility of transmitting such a polymorphism from her husband to her offspring. In the case of a weaker, but still statistically significant correlation between a polymorphic set and human disease, immediate therapeutic intervention or monitoring may not be justified.
Nevertheless, the patient can be motivated to begin simple life-style changes (e.g., diet, exercise) that can be accomplished at little cost to the patient but confer potential benefits in reducing the risk of conditions to which the patient may have increased susceptibility by virtue of variant alleles. Identification of a polymorphic set in a patient correlated with enhanced receptiveness to one of several treatment regimes for a disease indicates that this treatment regime should be followed.

For animals and plants, correlations between characteristics and phenotype are useful for breeding for desired characteristics. For example, Beitz et al., US
5,292,639 discuss use of bovine mitochondrial polymorphisms in a breeding program to improve milk production in cows. To evaluate the effect of mtDNA D-S loop sequence polymorphism on milk production, each cow was assigned a value of 1 if variant or 0 if wildtype with respect to a prototypical mitochondrial DNA
sequence at each of 17 locations considered. Each production trait was analyzed individually with the following animal model:
Y;~kp~ ~.L + YS; + P~ + Xk + (3~ + ... (3,~ + PEn + an +ep where Y;~k~P 1S the milk, fat, fat percentage, SNF, SNF percentage, energy concentration, or lactation energy record; ~ is an overall mean; YS; is the effect common to all cows calving in year-season; Xk is the effect common to cows in either the high or average selection line; ~3; to ~31~ are the binomial regressions of production record on mtDNA D-loop sequence polymorphisms; PE~ is permanent environmental effect common to all records of cow n; a" is effect of animal n and is composed of the additive genetic contribution of sire and dam breeding values and a Mendelian sampling effect; and eP is a random residual. It was found that eleven of seventeen polymorphisms tested influenced at least one production trait.
Bovines having the best polymorphic forms for milk production at these eleven loci are used as parents for breeding the next generation of the herd.
D. Genetic Mapping of Phenotypic Traits The previous section concerns identifying correlations between phenotypic traits (e.g., IBD) and polymorphisms that directly or indirectly contribute to those traits, such as those identified in Table 3. The present section describes identification of a physical linkage between a genetic locus associated with a trait of interest and polymorphic markers that are not associated with the trait, but are in physical proximity with the genetic locus responsible for the trait and co-segregate with it. Such analysis is useful for mapping a genetic locus associated with a phenotypic trait to a chromosomal position, and thereby cloning genes) responsible for the trait. See Lander et al., Proc. Natl. Acad. Sci. (USA) 83, 7353-7357 (1986);
Lander et al., Proc. Natl. Acad. Sci. (USA) 84, 2363-2367 (1987); Donis-Keller et al., Cell 51, 319-337 (1987); Lander et al., Genetics 121, 185-199 (1989)).
Genes localized by linkage can be cloned by a process known as directional cloning.
See Wainwright, Med. J. Australia 159, 170-174 (1993); Collins, Nature Genetics 1, (1992).
S Linkage studies are typically performed on members of a family. Available members of the family are characterized for the presence or absence of a phenotypic trait and for a set of polymorphic markers. The distribution of polymorphic markers in an informative meiosis is then analyzed to determine which polymorphic markers co-segregate with a phenotypic trait. See, e.g., Kerem et al., Science 245, (1989); Monaco et al., Nature 316, 842 (1985); Yamoka et al., Neurology 40, 226 (1990); Rossiter et al., FASEB Journal S, 21-27 (1991).
Linkage is analyzed by calculation of LOD (log of the odds) values. A lod value is the relative likelihood of obtaining observed segregation data for a marker and a genetic locus when the two are located at a recombination fraction 8, versus the situation in which the two are not linked, and thus segregating independently (Thompson & Thompson, Genetics in Medicine (5th ed, W.B. Saunders Company, Philadelphia, 1991); Strachan, "Mapping the human genome" in The Human Genome (BIOS Scientific Publishers Ltd, Oxford), Chapter 4). A series of likelihood ratios are calculated at various recombination fractions (6), ranging from 8 = 0.0 (coincident loci) to 8 = 0.50 (unlinked). Thus, the likelihood at a given value of 8 is: probability of data if loci linked at 8 to probability of data if loci unlinked. The computed likelihoods are usually expressed as the logo of this ratio (i.e., a lod score). For example, a lod score of 3 indicates 1000:1 odds against an apparent observed linkage being a coincidence. The use of logarithms allows data collected from different families to be combined by simple addition. Computer programs are available for the calculation of lod scores for differing values of 8 (e.g., LIPED, MLINK (Lathrop, Proc. Nat. Acad. Sci. (USA) 81, 3443-3446 (1984)).
For any particular lod score, a recombination fraction may be determined from mathematical tables. See Smith et al., Mathematical tables for research workers in human genetics (Churchill, London, 1961); Smith, Ann. Hum. Genet. 32, 127-150 (1968). The value of 8 at which the lod score is the highest is considered to be the best estimate of the recombination fraction.

Positive lod score values suggest that the two loci are linked, whereas negative values suggest that linkage is less likely (at that value of 8) than the possibility that the two loci are unlinked. By convention, a combined lod score of +3 or greater (equivalent to greater than 1000:1 odds in favor of linkage) is considered definitive evidence that two loci are linked. Similarly, by convention, a negative lod score of -2 or less is taken as definitive evidence against linkage of the two loci being compared. Negative linkage data are useful in excluding a chromosome or a segment thereof from consideration. The search focuses on the remaining non-excluded chromosomal locations.
IV. Modified Polypeptides and Gene Sequences The invention further provides variant forms of nucleic acids and corresponding proteins. The nucleic acids comprise one of the sequences described in Table 3, in which the polymorphic position is occupied by one of the alternative bases for that position. Some nucleic acids encode full-length variant forms of proteins. Similarly, variant proteins have the prototypical amino acid sequences encoded by nucleic acid sequences shown in Table 3, (read so as to be in-frame with the full-length coding sequence of which it is a component) except at an amino acid encoded by a codon including one of the polymorphic positions shown in Table 3.
That position is occupied by the amino acid coded by the corresponding codon in any of the alternative forms shown in Table 3.
Variant genes can be expressed in an expression vector in which a variant gene is operably linked to a native or other promoter. Usually, the promoter is a eukaryotic promoter for expression in a mammalian cell. The transcription regulation sequences typically include a heterologous promoter and optionally an enhancer which is recognized by the host. The selection of an appropriate promoter, for example trp, lac, phage promoters, glycolytic enzyme promoters and tRNA
promoters, depends on the host selected. Commercially available expression vectors can be used. Vectors can include host-recognized replication systems, amplifiable genes, selectable markers, host sequences useful for insertion into the host genome, and the like.

The means of introducing the expression construct into a host cell varies depending upon the particular construction and the target host. Suitable means include fusion, conjugation, transfection, transduction, electroporation or injection, as described in Sambrook, supra. A wide variety of host cells can be employed for expression of the variant gene, both prokaryotic and eukaryotic. Suitable host cells include bacteria such as E. coli, yeast, filamentous fungi, insect cells, mammalian cells, typically immortalized, e.g., mouse, CHO, human and monkey cell lines and derivatives thereof. Preferred host cells are able to process the variant gene product to produce an appropriate mature polypeptide. Processing includes glycosylation, ubiquitination, disulfide bond formation, general post-translational modification, and the like. As used herein, "gene product" includes mRNA, peptide and protein products.
The protein may be isolated by conventional means of protein biochemistry and purification to obtain a substantially pure product, i.e., 80, 95 or 99%
free of cell component contaminants, as described in Jacoby, Methods in Enzymology Volume 104, Academic Press, New York (1984); Scopes, Protein Purification, Principles and Practice, 2nd Edition, Springer-Verlag, New York (1987); and Deutscher (ed), Guide to Protein Purification, Methods in Enzymology, Vol. 182 (1990). If the protein is secreted, it can be isolated from the supernatant in which the host cell is grown. If not secreted, the protein can be isolated from a lysate of the host cells.
The invention further provides transgenic nonhuman animals capable of expressing an exogenous variant gene and/or having one or both alleles of an endogenous variant gene inactivated. Expression of an exogenous variant gene is usually achieved by operably linking the gene to a promoter and optionally an enhancer, and microinjecting the construct into a zygote. See Hogan et al., "Manipulating the Mouse Embryo, A Laboratory Manual," Cold Spring Harbor Laboratory. Inactivation of endogenous variant genes can be achieved by forming a transgene in which a cloned variant gene is inactivated by insertion of a positive selection marker. See Capecchi, Science 244, 1288-1292 (1989). The transgene is then introduced into an embryonic stem cell, where it undergoes homologous recombination with an endogenous variant gene. Mice and other rodents are preferred animals. Such animals provide useful drug screening systems.

In addition to substantially full-length polypeptides expressed by variant genes, the present invention includes biologically active fragments of the polypeptides, or analogs thereof, including organic molecules which simulate the interactions of the peptides. Biologically active fragments include any portion of the S full-length polypeptide which confers a biological function on the variant gene product, including ligand binding, and antibody binding. Ligand binding includes binding by nucleic acids, proteins or polypeptides, small biologically active molecules, or large cellular structures.
Polyclonal and/or monoclonal antibodies that specifically bind to variant gene products but not to corresponding prototypical gene products are also provided.
Antibodies can be made by injecting mice or other animals with the variant gene product or synthetic peptide fragments thereof. Monoclonal antibodies are screened as are described, for example, in Harlow & Lane, Antibodies, A Laboratory Manual, Cold Spring Harbor Press, New York (1988); Goding, Monoclonal antibodies, Principles and Practice (2d ed.) Academic Press, New York (1986). Monoclonal antibodies are tested for specific immunoreactivity with a variant gene product and lack of immunoreactivity to the corresponding prototypical gene product. These antibodies are useful in diagnostic assays for detection of the variant form, or as an active ingredient in a pharmaceutical composition.
V. Kits The invention further provides kits comprising at least one allele-specific oligonucleotide as described herein. Often, the kits contain one or more pairs of allele-specific oligonucleotides hybridizing to different forms of a polymorphism.
In some kits, the allele-specific oligonucleotides are provided immobilized to a substrate. For example, the same substrate can comprise allele-specific oligonucleotide probes for detecting at least 10, 100 or all of the polymorphisms shown in Table 3. Optional additional components of the kit include, for example, restriction enzymes, reverse-transcriptase or polymerise, the substrate nucleoside triphosphates, means used to label (for example, an avidin-enzyme conjugate and enzyme substrate and chromogen if the label is biotin), and the appropriate buffers for reverse transcription, PCR, or hybridization reactions. Usually, the kit also contains instructions for carrying out the methods.
The following Examples are offered for the purpose of illustrating the present invention and are not to be construed to limit the scope of this invention.
The teachings of all references cited herein are hereby incorporated herein by reference.
EXAMPLES
With the goal of identifying IBD susceptibility genes, a genomewide scan was undertaken in 163 pedigrees, and three regions of suggestive linkage (3, Sq31-33, 6p) and one of significant linkage to 19p13 (LOD = 4.6) were identified.
Higher density mapping in the suggestive Sq31-33 region revealed a CD susceptibility locus of genome-wide significance (LOD = 3.9). Importantly, the Sq31-p33 localizes to the major immunoregulatory cytokine gene cluster and the 19p13 locus to a region containing numerous genes encoding cytokine/chemokine receptors and other inflammatory-associated molecules that could have a direct role in disease susceptibility.
In order to pursue the evidence of linkage to chromosome 5, a systematic linkage disequilibrium (LD) approach was adopted. The approach that was used in the first stage of LD mapping was to genotype all known microsatellite markers in the 18 cM between DSS1435 and DSS1480, as these two markers delimit a region of a 2 LOD drop on either side of the linkage peak centered at marker DSS2497.
All alleles for each marker were examined for evidence of excess transmission from heterozygous parents to CD child using the transmission disequilibrium test (TDT).
Only alleles at two of the 57 markers had significant CZ results (p<0.001):
IRFIpl (CZ=13.3, p=0.0003) and D5S1984 (CZ=14.0, p=0.0002) (Table 1). A second stage of mapping was then undertaken to confirm, as well as to better delimit, the region of LD surrounding IRFlpland DSS1984. The development of new microsatellite markers was necessary. The marker with the most significant Cz result was CAhl7a (Cz=16.2, p=0.00006) and was located between IRF 1 p 1 and DS S 1984 (Table 2).
Furthermore, the alleles 193, 156, 373, 140, 222, and 307 at markers GAhl8a, IRFIp, CAhlSa, CAhl7a, DSS1984, CSF2p10, respectively, define ahaplotype conferring susceptibility to Crohn's disease (CD). In order to identify the sequence variant that would explain the genetic susceptibility to CD provided by this haplotype, a search was performed for all single nucleotide polymorphisms (SNPs) in this region of LD. The SNP discovery was accomplished by direct sequencing of overlapping PCR products amplified from DNA samples from eight individuals (six S CD patients, one unaffected family member, and one CEPH DNA as control).
Table 3 shows the results of the SNP discovery analyses.
139 triads were genotyped for a total of 241 SNPs thus far, where at least 50 trios were fully genotyped. Using a CZ value of 13 (corresponding to a p-value of 0.05) as threshold, 12 SNPs were found to have a significant level of association with CD and extended over a region of 250 kb, from IRF1 to prolyl4 hydroxylase.
These were markers IGR2055a 1, IGR2060a 1, IGR2063b-1, IGR2069a 2, IGR2078a 1, IGR2096a l, IGR2198a 1, IGR2230a 1, IGR2277a 1, IGR3081a l, IGR3096a 1, PROLYLex3_1 (see Table 4). Any of these best SNPs by themselves are in strong association with CD and fully explain the microsatellite LD
observations. Furthermore, the best SNPs have nearly identical association characteristics (that is, the allele at one SNP determines the allele of all others on any phased chromosome), confirming that a single risk haplotype extending approximately 250 kb is the source of all the observations of association in this region. Specifically, this haplotype is defined by the alleles G, C, G, T, A, A, G, T, G, G, C, T at markers IGR2055a-1, IGR2060a 1, IGR2063b-1, IGR2069a 2, IGR2078a 1, IGR2096a 1, IGR2198a 1, IGR2230a 1, IGR2277a 1, IGR3081a 1, IGR3096a 1, PROLYLex3-1, respectively. The frequency of this haplotype is estimated to be approximately 37% in the general population. Furthermore, this haplotype is transmitted from heterozygous parents to CD patients at a ratio of 2.5:1.
Families For the linkage study, multicase families with 2 or more siblings affected by IBD were identified by review of clinical charts of all patients registered in the Mount Sinai Hospital Inflammatory Bowel Disease Unit patient database and from the Hospital for Sick Children IBD database. Patients were also referred by physicians in the Greater Toronto Area (GTA). To confirm and update information obtained from these records, all patients were sent a questionnaire inquiring about the presence of a family history of IBD. Individuals identified as having other affected first-degree relatives were invited to participate and asked for permission to contact other affected and unaffected family members. Endoscopic, histological and radiological reports as well as clinical data were obtained on all affected individuals and these reports were reviewed for verification of diagnosis based upon standard . criteria. Venous blood sampling was performed on affected individuals and their parents, and DNA was extracted using a salting out procedure. Ethics approval for this study was given by the University of Toronto Ethics Committee and written informed consent was obtained from all participants.
All of the LD analyses in this study were performed with father-mother-affected child (CD only) triads, where 0 or 1 of the parents was affected with CD.
These triads either came from the multicase families used in the linkage stage of this study or were identified specifically for the purpose of the LD study.
Specifically, for the microsatellite genotyping, 296 triads were genotyped: 95 of these triads were derived from families used in the original identification of the IBDS locus (only one triad per family), and 201 were from newly collected families. For the SNP
genotyping, 139 triads were genotyped: 18 were derived from families used in the original identification of the IBDS locus, and 121 were from the newly collected families. Individuals affected by CD were identified by review of the clinical charts of all patients registered in the Mount Sinai Hospital Inflammatory Bowel Disease Centre patient database and from the Toronto Hospital for Sick Children IBD
database. Written informed consent was obtained from all participants and ethics approval for this study was granted by the University of Toronto Ethics Committee.
Microsatellite Genotyping Genomic DNA was extracted from peripheral blood lymphocytes from probands and family members from 163 Caucasian pedigrees. The genome-wide scan, with an average inter-marker spacing of 12 cM, was carried out using a modified version of the Cooperative Human Linkage Centre (CHLC) Screening Set/version 6.0 that also included Genethon markers. These 312 loci were amplified using fluorescently-labeled primers (Research Genetics Inc., Huntsville AL) in separate polymerase chain reactions, and the products were then multiplexed into panels by pooling before electrophoresis on ABI 377 sequencers (PE Applied Biosystems, Foster City, CA). Fluorescent genotyping gels were analyzed in an automated system developed at the Whitehead Institute/MIT Center for Genome Research. Further details of the genotyping system have previously been described (Rioux et al., Gastroenterology 115:1062-1065 (1998)).
The region of suggestive linkage on chromosome 5 and the surrounding regions of poor information content were followed up with 34 additional microsatellite markers. Specifically, 34 markers were genotyped between markers DSS1470 and DSS1471, decreasing the average spacing between markers to approximately 3 cM in this 125 cM region. This higher density mapping was performed on the original samples and on additional 12 families, for a total of 175 pedigrees analyzed. These new families consisted of 16 CD affected sibpairs.
In the first phase of the microsatellite LD mapping, a total of 57 microsatellite markers were genotyped on 296 CD triads. Information regarding primer sequence, allele size range, and suggested amplification conditions for 55 of these genetic markers (all but IRFlpI and CSF2p10) can be obtained from the Genethon (http://www.genethon.fr/), Marshfield (http://research.marshfieldclinic.org/genetics/), or Genome Database (http://www.genethon.fr) World Wide Web sites. The markers IRFIpI, CSF2pl, and the 8 markers used in the 2nd stage of LD mapping, were designed during the course of this study. Genotypes for all of these markers were obtained as described above.
SNP Discovery In order to identify all SNPs in the IBDS critical region, a tiling path of overlapping PCR roducts was designed. Specifically, PCR assays were designed using Primer 3.0 to be approximately 700 by in length, with 100 by overlap with adjacent assays. The -21 M13 forward and the -28 M13 reverse sequences were added to each of the forward and reverse PCR primers, respectively. These PCR
primers were used to amplify 50 ng of genomic DNA from six CD patients, one unaffected family member, and one CEPH DNA as control. The PCR products were purified using the solid phase reversible immobilization (SPRI) method and then sequenced using the appropriate -21 M13 or -28 M13 DYEnamic Direct Cycle Sequencing kit (Amersham Pharmacia Biotech Ltd, Cleveland, OH). All sequencing reactions were run on ABI377 automated sequencers (PE Applied BioSystems, Foster City, CA); the gel files were processed using the BASS software, available on the Whitehead Institute/MIT Center for Genome Research FTP site. Sequences were base-called by the Phred program, and then the forward and reverse reads were assembled by the Phrap program. All traces were visually inspected by at least two observers.
SNP genotyping SNP genotyping was performed using length-multiplexed single-base extension (LM-SBE) as previously described. Briefly, PCR primers were designed as close as possible to the SNPs identified in the current study, resulting in a product of a maximum length of 150 bp. Forward primers had T7 tails at their 5' ends and reverse primers had T3 tails at their 5' ends. These T7 and T3 tails were used for secondary amplification. Primer pairs were checked for homology to all amplicons and sorted into pools consisting of up to 50 primer pairs. Loci were subjected to two rounds of PCR amplification. In the first round, 10 ng of genomic DNA was amplified using a pool of primer pairs (0.1 mM) and 2.5 units of Amplitaq Gold (Perkin Elmer). In the second round, a 3 mL aliquot of the primary amplification product was amplified with biotinylated-T7 and biotinylated-T3 primers. A 7 mL
aliquot of this secondary amplification product was purified from the unincorporated dNTPs using streptavidin-coated Dynabeads (Dynal). A multiplex SBE reaction was then carried out on the purified product using SNP-specific primers, JOE-ddATP (0.12 M),TAMRA-ddCTP (0.12 M), FAM-ddGTP (0.12 M),ROX-ddUTP
(0.60 M; NEN DuPont) and Thermosequenase (0.5 U; Amersham). Excess ddNTPs were removed from the SBE products using 96-well gel filtration blocks (Edge Biosystems) prior to electrophoresis on ABI 377 sequencers. The SBE gels were analyzed using a system developed at the Whitehead Institute/MIT Center for Genome Research as previously described.

Statistical analysis Nonparametric multipoint linkage analysis of the data from the genome-wide scan and the higher density mapping on chromosome 5 was performed using the MAPMAKER/SIBS functions implemented in GENHUNTER 2Ø It is important to note that all sib pairs from sibships with more than 2 affecteds were counted but were conservatively downweighted by a factor of 2/n (where n =the number of affecteds). Exclusion mapping was also performed with this software package, and a locus 8s > 2 was considered excluded at a LOD score of -2.
To establish appropriate thresholds for suggestive and significant genome-wide linkage for these particular datasets, simulations were performed by generating artificial genotype data with the identical family structures. These simulations matched the datasets with respect to marker density, marker informativeness, the individuals genotyped, affected status, and the fraction of missing data.
To assess the significance of the TDT results for each marker, permutation tests using the same genotype data were carned out. For each trio, chromosomes were randomly reassigned as transmitted or untransmitted to form a permuted dataset. The number of permuted datasets with values as significant as that seen for the best single-marker and two-marker tests were tabulated. In order to quantify the extent of LD in the IBDS region, 3-marker haplotypes were examined using the TDT
and Pexcess (d)~ Pexcess represents the strength of LD and is calculated by (paffected - pnormal) / (1 - pnormal). In our study, the Paffected is calculated from the frequency of the haplotype among the transmitted parental chromosomes and Pnormal is the frequency among untransmitted parental chromosomes.

(This page has been intentionally left blank.) (This page has been intentionally left blank.) Table 1. Summary of the first stage of LD mapping using microsatellite markers.
MarkerMarkerSourceEstimatedDistancePrevious TDT results # Name o Geneticto nextlinks a markerPositionmarker results AlleleXZ pvalue ' MLOD
' 1 D5S1435G 128.50 0.50 0.76 115 5.84 0.016 $ 2 AFMa113G 129.00 0.83 e9 3 D5S1505M 129.83 0.00 0.79 4 D5S1384U 129.83 0.00 5 D5S471G 129.83 0.57 0.79 238 7.58 0.0059 6 D5S632G 130.40 0.20 114 4.59 0.032 1 7 D5S818M 130.60 0.20 ~

8 D5S2502M 130.80 0.10 9 AFMB35G 130.90 0.04 10 D5S1975G 130.94 0.00 11 D5S622G 130.94 1.86 1$ 12 D5S2059G 132.80 0.85 190 5.83 0.016 13 D5S615U 133.65 0.00 1.8 14 D5S804M 133.65 0.00 1.8 15 D5S1495M 133.65 0.00 1.8 382 4.00 0.045 16 GATA68M 133.65 0.35 2.2 17 D5S809M 134.00 0.40 2.1 18 D5S2120G 134.40 0.20 19 D5S642G 134.60 0.65 2.6 20 D5S2057G 135.25 0.00 3.1 21 D5S2110G 135.25 0.62 3.1 2$ 22 IRF1 S 135.87 0.19 156 13.27 0.00027 23 D5S1984G 136.06 0.16 222 14.04 0.00018 24 CSF2 S 136.22 0.58 307 4.00 0.045 25 D5S2497G 136.80 0.10 3.9 129 7.69 0.0055 26 w2429/24G 136.90 0.10 owa7 27 w866/057G 137.00 0.10 v 28 D5S1766U 137.10 0.10 3.5 245 6.48 0.011 29 D5S808M 137.20 0.10 3.3 30 D5S458G 137.30 0.00 3.1 31 D5S396G 137.30 0.09 3$ 32 D5S2053G 137.39 0.56 3.0 33 D5S1995G 137.95 0.69 2.8 34 D5S2115G 138.64 0.68 2.4 35 IL9 M 139.32 0.01 2.0 36 D5S816M 139.33 0.07 2.0 37 D5S393G 139.40 0.10 2.0 38 D5S399G 139.50 0.90 2.0 127 4.57 0.032 39 D5S479G 140.40 0.10 40 AFM350yG 140.50 0.10 b1 41 D5S1983G 140.60 0.12 116 4.55 0.033 45 42 D5S476G 140.72 0.00 1.7 43 D5S500G 140.72 0.28 1.7 211 4.15 0.042 44 AFMB29G 141.00 0.82 45 D5S414G 141.82 0.98 46 D5S2009G 142.80 0.12 140 6.70 0.01 $0 47 D5S658G 142.92 0.00 2.0 48 D5S2116G 142.92 1.08 49 D5S2011G 144.00 0.06 50 D5S2119G 144.06 0.00 51 D5S1979IG 144.06 1.15 I - - I - I

52 D5S2017G 145.21 2.19 2.2 91 5.40 0.02 53 D5S2859M 147.40 0.09 54 D5S436G 147.49 0.00 1.6 55 D5S207M 147.49 0.00 56 D5S1480M 147.49 1.6 ' Abbreviations: G, Genethon; M, Marshfield; U, Utah; S, designed by authors from genomic sequence.
Z Estimated from genetic (Genethon, Marshfield) and physical (data not shown) map information ' Linkage data for the CD subgroup with early onset disease as seen in figure 1 and reference ##I#
' Results are shown only if pvalue < 0.05 Table 2. Summary of combined LD mapping information.
MarkerMarker DistanceLD TDT results # Name to next ma in marker stage Allele T:U XZ pvalue kb 57 CAh14b 43 2 58 ATTh14c167 2 59 IL4m2 164 2 214 1.8 4.74 0.029 60 GAh18a 21 2 193 1.4 0.018 22 IRF1 24 1 156 1.7 13.27 0.00027 61 CAh 130 2 373 1.5 7.73 0.0054 15a 62 CAh17a 97 2 140 1.8 16.19 0.00005 23 D5S1984163 1 222 1.8 14.04 0.00018 24 CSF2 178 1 307 1.4 4.00 0.045 63 CAh81 85 2 b 64 CAh81 2 c N O U U O V O

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N O O N N N N N OO N NN O NO

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I I I N ~ N ~~ v ~~I I I
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I l N N N ~ ~ ~ ~X X __ X XN
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c,.) c0 c O O OO O Op X X O O O O O O ON ~ ~~ ~ ~I
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Table 4. Summary of best SNPs in chromosome 5 region.
SNP ApproximSNP TranFrequenTrans UntraC' p-value markerate type smittcy muted nsmitt of name Physical ed allele ed position allel ' a IGR2055435.0 G/T G 0.357 87 39 18.290.000019 a 1 IGR2060437.5 C/G C 0.351 81 34 19.210.000012 a 1 IGR2063439.0 C/G G 0.359 87 37 20.160.000007 b 1 IGR2069442.0 C/T T 0.627 52 20 14.220.00016 a2 IGR2078446.5 A/G A 0.364 48 16 16.000.000063 al IGR2096455.5 A/C A 0.349 75 32 17.280.000032 al IGR2198506.5 C/G G 0.364 87 41 16.530.000048 a 1 IGR2230522.5 C/T T 0.415 67 28 16.010.000063 a 1 IGR2277546.0 A/G G 0.417 79 37 15.210.000096 a 1 IGR3081609.0 G/T G 0.338 79 35 16.980.000038 al IGR3096616.5 C/T C 0.429 89 42 16.860.00004 al PROLY 686.5 G/T T 0.383 79 39 13.560.00023 Lex3 ' Position (kb) on the 850 kb reference sequence.
z Frequency of allele calculated from the untransmitted parental chromosomes.

TABLE S
>IGR2001 a ggcccgaaaggactgtgccccctccccgtcaaacaccccccccccgcgtcccccaccaag ttctggccggggctgtggagcgtgggtcacctgggggcgaaggactccacatcacggtga agtggaggtgctgcagcccccacaaagcccgagaagcctgccaggggcgccccgggcgaa cggcagtgggcgtgggccgttctgcagcacccattggcgcgggggaggagagtgctgatc ccatcaagccccgctccaggtcgcggccgctgggcctggcccaggagcctcccccggcct cggggccccatgggactgacagggggctgagttctctttcctcccaacggcggtgtttat aagaaatgaagctccgcagcggccatcagcggcagcccacactgtcaccccgccccgctc tcagggggttccggaacagccctgagcactggagcaattccttggctcagtattctatca tgaccccctagtgattttccagccagcttcagccccacattctgcatttaggaattttat aacagtgcaacgtttattctgctgtgtcatacagcatattttgccaaacctttgagaggg gaggggctggtctggtgccccagtgtatctccagaaccaaacctggggttcaccaaaaag caggcctgcgtgattcatatgtgttgaatgaattaaggga >IGR2002a cagccagcttcagccccacattctgcatttaggaattttataacagtgcaacgtttattc tgctgtgtcatacagcatattttgccaaacctttgagaggggaggggctggtctggtgcc ccagtgtatctccagaaccaaacctggggttcaccaaaaagcaggcctgcgtgattcata tgtgttgaatgaattaagggactttctttctctccagttaggctccttgcaggcagggtg atgacccttggattctgccttcaagcttttggatgcttttatttctggcttgtgttctgc aattcacagtttaggactgcctgcctcccaggtttctgtgaaaatcgagatgaaggattt gagcatttcagagagccctactacttctggacctggaacctggaaggcatgctggggagt ttgtctgctttggggaccgtggccccctctctgggtagcaggctccacaggtagcaggtc tcccagtcgaaaacctagttcaggtcgggcgccgtggctcatgcctataatcccagcact ttgggaggccgaggcggtggatcacctgaggtcaggagttggagaacagcctggccaatg tggtgaaactccatctccaccaaaaatacaaaaattagctgggcatggtggcgggtgcct gtaatcccagctacttgggaggctgaggcaggagaattgc >IGR2003 a tcaggtcgggcgccgtggctcatgcctataatcccagcactttgggaggccgaggcggtg gatcacctgaggtcaggagttggagaacagcctggccaatgtggtgaaactccatctcca ccaaaaatacaaaaattagctgggcatggtggcgggtgcctgtaatcccagctacttggg aggctgaggcaggagaattgctgaacccctggaggtagaggttgcagtgagccgagatca cgtcactgcactccagcctgggtgacagagcgagactccgtctcaaaaaaacaaaacaaa aaaacacctagtttaaacctcactggcacctgcacctcagctctcacaaactctcatttc tgagcacacactcatctctatcagcagaggatttaaccacaggttgccaagaaatgtctg tatctgagagaattcataatctgagatagaaggaacactaaactccagaggaagaggggt cacacatcaacttaactaggatttactgagtgcctaccatggtagccactcttcggggga gtgcaaggatggcggcatcaccttagtgtggtccgtgtggccctgtgcattgatgtgtgt gtgcatggtgacatgttgggagccatgcttctgggcttcaggactaactgcagcccactt agggggtgaacagtgttttgagagcctgagggaggggact >IGR2004a gatttactgagtgcctaccatggtagccactcttcgggggagtgcaaggatggcggcatc _87_ accttagtgtggtccgtgtggccctgtgcattgatgtgtgtgtgcatggtgacatgttgg gagccatgcttctgggcttcaggactaactgcagcccacttagggggtgaacagtgtttt gagagcctgagggaggggactggggacaagaattgtctgtcagggtagaggctcccacag ggtgtgtgaatgtgtgtgtgagatgatcttgccttcagcatcctgattgcagaagtcact tcaaaggagcccctgccagccagttagcctcctcttgccagcacagaaaaatccaggtcc caatacagagaggccacacaatgaattcaccctcattgagtgaggctatggatgagaggc atctgtaaggaagaccttgcacagtgcagggtgctggctaccctcagctaacccctagct cgcttcagctgctgggcatgaggaacctgcttagatttctcacagaaaacatggagagtt ctttttctcacagaaaaaatgtagagtttgttccccagagtttgttcccaccatgtagaa agtgaccagtggtgaaaaggaaacataggaaagttaaggaccaaagggtccaaggaggga aaagaaaggacttctggttggttgctttgcgggcattttg >IGR2005 a gaggaacctgcttagatttctcacagaaaacatggagagttctttttctcacagaaaaaa tgtagagtttgttccccagagtttgttcccaccatgtagaaagtgaccagtggtgaaaag gaaacataggaaagttaaggaccaaagggtccaaggagggaaaagaaaggacttctggtt ggttgctttgcgggcattttgaagagatcaggcatatgctctgggccttaaaaaaagaca cagagattgaagtggtggggtgggcaagggagagagagatggagagagggtgagtgttgc caagtatcctgaggagacagggatgaggggacaaacacattgtgttcagataatggaaat acagtgaaaggttcatgcgttcctgttcatacatttcatttgacttatgtcttacagttt ggaaataattttgatagtctaattttacaattaggagagatggagagagattatctctat tttacagatgagaaaactgagccccagagagggacagtaacttgctaagatcacatagca agtggaaaaagcacaataagaacccaggctttcagactcaaatcctgtgttctcttttca tccccctttagtttcatctttcctactgccaagggtagggaagctgtcagggacagaagg ttggaatgggaccccaggacaagactgagcagagatttga >IGR2006a agccccagagagggacagtaacttgctaagatcacatagcaagtggaaaaagcacaataa gaacccaggctttcagactcaaatcctgtgttctcttttcatccccctttagtttcatct ttcctactgccaagggtagggaagctgtcagggacagaaggttggaatgggaccccagga caagactgagcagagatttgaatgtggggctgaatgtaggggagctcagaaggctcctgg gtggccccgagtgttagggagatcatccgagttagggagatcattccagtgcagaggcac catcttccccatctacctgggcaaggcaaggaggcccaaggggaggttggggcaacaata gtctggtcctggactatgaaatcacaacccgatacagggaaggaagacccagaagaccag gtgggaaagaaaagggctggctccgaattaataagagcctacaggagcctatgtgttctg ctggggatcacagaatgttctacatcttagaatgtgattcatcaaaagccattacaataa aaatgttgggtacttaaacatggcttagctttatttcactgatttggagtatagcacccc tagtcataataagcatattcttacaggcttcaaaataaagtaagaatccctaaggttaaa aaaaaaaaaaaggtcaaagatgtaaatgtaaatgacagtt >IGR2007a ctacatcttagaatgtgattcatcaaaagccattacaataaaaatgttgggtacttaaac atggcttagctttatttcactgatttggagtatagcacccctagtcataataagcatatt cttacaggcttcaaaataaagtaagaatccctaaggttaaaaaaaaaaaaaaggtcaaag atgtaaatgtaaatgacagtttcattggtaaatcctaactggggaatttctcctaagcaa aaaattattgatatgcacaaagatttagctaatagtgttgtttgtattacgaaaaaatgg aaataacctaactgtcctacaataggggattaattgggtaaatttttatttatccttgtg aaagaataatgtatacctattacaaatgacattgcataagtacatttcatgacatggaaa _88_ gatgctcattatggctaaatatacatatgcatatacgggtatatttatacctgtatctgt gaattaaaattaagtttttgttttaaagcattttttatagtgtcctgttgccttcacagg gtcactgtggtcaacttatcagaccacaaagatgcaaacttcctttccctaatctcatcc tgaattttccagtggatgtgtcaggttctcaggggaaggacaagcatctatttgctgtac caagaaaggatcccacgactcaggggtcacttgttttctc >IGR2008a gttttaaagcattttttatagtgtcctgttgccttcacagggtcactgtggtcaacttat cagaccacaaagatgcaaacttcctttccctaatctcatcctgaattttccagtggatgt gtcaggttctcaggggaaggacaagcatctatttgctgtaccaagaaaggatcccacgac tcaggggtcacttgttttctcttattcttgctcagaaggtcttggtccctgtagcaagtc cccacttccatttgtcacttaaagtaccccaaaacccacctttccattccagagtgtcat tgccctccactttgcttaacactcagttaggttccttcctcagtttctcctacctccttt cctctcctagctcctgacccacctctatctggtagacagttttgcccattcctgctggta tcctgggaaccaggtttggcattggtcacagcactcagattgcaatgcgccagaatggga ttaacccatgcatttcctctacgggagggaggtagagtgactggcaagtcgaatgttgca tgggtgtgtctatttatagcctgcaaaatggggtgctgccctggagggagagctgcggtg aaggaaatgacacgcctgggagagtaacttacttctgcaggagctctagggagatgaagg aagaagcctcctgggccagagttttggatggaaaatgaac >IGR2009a tacgggagggaggtagagtgactggcaagtcgaatgttgcatgggtgtgtctatttatag cctgcaaaatggggtgctgccctggagggagagctgcggtgaaggaaatgacacgcctgg gagagtaacttacttctgcaggagctctagggagatgaaggaagaagcctcctgggccag agttttggatggaaaatgaacacccagtcaagtctctaggactatacgtggggcggggac tagttgtgcgcgagagttaagtaggggcccttaccaaggagcatgggacctgggctcccc aaccctttggctagccccatggcgttgatcagccctgagctaattcctccatgctgccca gaacctctctgggccaagccctggggactcagagatgacagcaatgcttccattgcggaa ctcccatacgcgggccacagggaggctctggaggcggcctgaggcaagagtgctaggagg gatcagagctagcccacccctaccctcactcagccgtctgggcttctctgaaccccttct cctcctctgttccctaaagccagccagggggagtcccagggaggcagaccgaaaaggggt ggggtgtcatcctggtcactattagaccctgcaacggcgaccttgaaaactactcagcgt ctgttgcccgagtggagcatagtgctttacaatctcttcc >IGR201 Oa ctaccctcactcagccgtctgggcttctctgaaccccttctcctcctctgttccctaaag ccagccagggggagtcccagggaggcagaccgaaaaggggtggggtgtcatcctggtcac tattagaccctgcaacggcgaccttgaaaactactcagcgtctgttgcccgagtggagca tagtgctttacaatctcttcccatcacagcaaaccatcaaggtagggctactgttatttt atggttgaaaaacagaggtcctgcgtcccttgggggctgtgccagcagcggccaagttgg gatttcccctggtccagcagccccagacagcacacggggcagggtaggctttctgcctcc ttcacttccccagggcaggtgagtgacctggagggagggggtcacccctaaaaacagggg tagtgctaggactgaaaccctcccttcttgatatcccactggcaagcttgaggagccagg ctgccagtcgggagattcggcccagtgttcccactggagagggcggcaagtgcccgggcg atcacctcgcctgcgttcgggagatatacctccgcccccgccccgccaggagggtgaaaa gatggccccaggagccagccggctgggacaaggcggagtgagaggacaggctggggccgg gggcgctgggctgtcccgggcagccctcctccgggcaagc >IGR2011 a gcccagtgttcccactggagagggcggcaagtgcccgggcgatcacctcgcctgcgttcg ggagatatacctccgcccccgccccgccaggagggtgaaaagatggccccaggagccagc cggctgggacaaggcggagtgagaggacaggctggggccgggggcgctgggctgtcccgg gcagccctcctccgggcaagccggagcaggggtggattgggagcgctcggggcgggcccg cggtggccccggggcggtggcgcccggccggagagggtggggcggagcagccgccctgta cttccccttcgccgctagctctacaacagcctgatttccccgaaatgacggcacgcagcc ggccaatgggcgcccgcgcggctgtccgggggcggggccggccagggctggggaatcccg ctaagtgtttggattgctcggtggcgccgctgccctggcagagctcgccactccttagtc gaggcaagacgtgcgcccgagccccgccgaaccgaggccacccggagccgtgcccagtcc acgccggccgtgcccggcggccttaagaacccggcaacctctgccttcttccctcttcca ctcggagtcgcgctccgcgcgccctcactgcagcccctgcgtcgccgggaccctcgcgcg cgaccgccgaatcgctcctgcagcagaggtgagtacgcct >IGR2012a agccccgccgaaccgaggccacccggagccgtgcccagtccacgccggccgtgcccggcg gccttaagaacccggcaacctctgccttcttccctcttccactcggagtcgcgctccgcg cgccctcactgcagcccctgcgtcgccgggaccctcgcgcgcgaccgccgaatcgctcct gcagcagaggtgagtacgcctttgaggcgcggggcaccggcggcgtcgaataaaaggcgc gcggggcaccaggaagtggggggtcgaaagctccaggctggagactcgccggcgcgcggc gttgcccgggcctccgcgcgggctccggggggcgccggaggagctgcgagccgcgggccg cggcgcggggagggcgggacgcggcgtggaccgcccacccggacgaggctgccggcgccc ggcagctttcgcagatctgcgtgcgcgcagccgccaggggcctgtaggtggcccgctatg ttcgtcccgcgcatccacacgccgtgccggggaccgagtgtcagcccacgcgtgggcgcc cagtgctcccggctttcggcggtcccagctccgcgcccaggcgacaggttttgggctccc tgtgctggtggcaagggctggcttactgcccaggtggctggagggaatcgtgacctacgg agactgcgggaagaggcgccacaggtgttccttgggccac >IGR2013a cgccgtgccggggaccgagtgtcagcccacgcgtgggcgcccagtgctcccggctttcgg cggtcccagctccgcgcccaggcgacaggttttgggctccctgtgctggtggcaagggct ggcttactgcccaggtggctggagggaatcgtgacctacggagactgcgggaagaggcgc cacaggtgttccttgggccacttctccagaggaggggaaaccgggccggaagggttagcg tcctggtcttagcgttgtgggcgctgtggctgtcaggaaggcgtagaatggattcagggg ggcgggagggggctgttcagggtgacggctagccctttgctagctagtggttacaactca agtcaagggaatttcttcttggcatcaagcaaaagaagtccctcccttcccaaaggattt gaattttgagcgaaaagttctgaaattagggtatctgtgcattttgtctcttttcctgca tatgaatcctgaagccatcacttgcatgcctgtctcctccagagactggctgggaggggc tgaaggaaggggcaaaagcatttttgcctaagatgctgaaaaaatttggagagcagtttt attccagcgcagctcccctccgcactgagtgtagtacctagcagctggctgaggtgaggg gagggtaactaagtgacctcgggtggggcaggtcactgcc >IGR2014a acttgcatgcctgtctcctccagagactggctgggaggggctgaaggaaggggcaaaagc atttttgcctaagatgctgaaaaaatttggagagcagttttattccagcgcagctcccct ccgcactgagtgtagtacctagcagctggctgaggtgaggggagggtaactaagtgacct cgggtggggcaggtcactgcccaggtactgttcaacagattccagactggagcctctgtg ttctctttacagccaacatgcccatcactcggatgcgcatgagaccctggctagagatgc agattaattccaaccaaatcccggggctcatctggattaataaagtgagtgtaactcttt gggttttcctgccactgttttaacccatgtacttctggagggaccaaagcttcagatgca gctcaaaaagggaagtgataacgggacaagcaggtgtttctcccagtgggtcctgcatgc agggagtgtgcacggcccagcctgggcctcacttgcatgactcctgccttcttcccttct tgaggtagggcacccacctgaaggcacttccagtttccagcagcaagactttccagcatc tgcagagctggagttctgctctcctctaagcgagacccttacaaacatacacagcactct gcagggctccaatcgaacaaatagaagactgagaagtgga >IGR201 Sa gcctgggcctcacttgcatgactcctgccttcttcccttcttgaggtagggcacccacct gaaggcacttccagtttccagcagcaagactttccagcatctgcagagctggagttctgc tctcctctaagcgagacccttacaaacatacacagcactctgcagggctccaatcgaaca aatagaagactgagaagtggatgctgctgggcagaaacgtgcctggcttagcagaggaca aacgagttaatcttgcaccagtcactctggcccaagaagcctatagctggtgcacttggg gcaacatagaccctatagacttagtagcaatgatagtattcataataatagctaatgctt actgaacactccctgtgtgcctggcacctgctaagtatgttatttacattgtgtcattta atcctcgcagtagtcctgtgggttagatcttactaatgtcatcattttcagataagtaaa cagaggcactgagaggtagatcataagatcacacaaaaagtgatgaagccaagatttgaa cttgaacggtctgactcagaaatctttactgttaaccataagtgatataataacagtaag accttagacttcatatttgtcactgtgtccctacacatcctctggtttttaatcctcaaa attttgttggatatgttttctcatttccgagaagagaaaa >IGR2016a atcataagatcacacaaaaagtgatgaagccaagatttgaacttgaacggtctgactcag aaatctttactgttaaccataagtgatataataacagtaagaccttagacttcatatttg tcactgtgtccctacacatcctctggtttttaatcctcaaaattttgttggatatgtttt ctcatttccgagaagagaaaactgaggggcaaagagatacagtgacaatgccagggttac acagtgttcaccatccaagtctagcccagagctccctcagtggtatgaccaggaccccct gtgtaagagcccatgctcccaggtgtcctgaggagtcctttctaatggaagaagttctta cttccatgtgggtgcttacaagccagagagaaacatcccagagcttcaaaaccagggctt tgggggagggtgccctgtgtgggtcctagcacatgtgtaacaggcagagggaggtctttg tgagctaataatgctgcagctcatccaaactaggtgtccctcctgagagatccagagtgg tctgtttaagccagcctcaagatgggtgtccaagccagatgtcaggggaaaaaaggggaa gtcagccttttctcagacctgtctggctgggcaggcctgggtctcagactcagcccca.aa gtctgtggtctctgacctgacacagccttatgtgtatgtg >IGR2017a ctcatccaaactaggtgtccctcctgagagatccagagtggtctgtttaagccagcctca agatgggtgtccaagccagatgtcaggggaaaaaaggggaagtcagccttttctcagacc tgtctggctgggcaggcctgggtctcagactcagccccaaagtctgtggtctctgacctg acacagccttatgtgtatgtgtgtattgttcaggaggagatgatcttccagatcccatgg aagcatgctgccaagcatggctgggacatcaacaaggatgcctgtttgttccggagctgg gccattcacacaggtgtgtgcctgggactcaggcctaggaagcccagggtagagacaaga ggaggcactcacgttaacacagaggctcttcactggggtccctgagctccctgagacaac atgcagaattactgggaagaggggctggtggcagacttgtgtttctggagaagagagtcg atcatctcagcaaattctcaaagggaaaagccaagatcttagaaagtgtgtggcttcagg gggtttgtggctagatgaaagttctccctggcaaaagcatctgtgaaaagcagctgtaag ccagggcactgaaagagacccaggtctgcctttttcttcgtgttgaccaaggcccttggt ccaagcctcatgtggttggtggcctcctttatccttgaga >IGR2018 a aaagggaaaagccaagatcttagaaagtgtgtggcttcagggggritgtggctagatgaa agttctccctggcaaaagcatctgtgaaaagcagctgtaagccagggcactgaaagagac ccaggtctgcctttttcttcgtgttgaccaaggcccttggtccaagcctcatgtggttgg tggcctcctttatccttgagagatggagctctaggcccatctcagaacagtcagcccacc catttagtaactgttctctgctgcccagtctgtgcccactctaccctctggctgctgata gcccaaggaggaagactgggcatagtctgagacacagatagtacactttggggatatggg gactctagtgcttctggctgggcccttcactgaggcccgctagatgtgtttaagccaagc ctgggcatttgagaaggcccagggcctaggacctgcagagtgtcaccgggagtacctgct ggtttgaccactgtggctctctggtagcataagaggtcaggggtaccttgccttcctcct tcaggccaggggcagctgaggatccctacccatggccctgacgatcctcttttttctcct gccctctaggccgatacaaagcaggggaaaaggagccagatcccaagacgtggaaggcca actttcgctgtgccatgaactccctgccagatatcgagga >IGR2019a tctggtagcataagaggtcaggggtaccttgccttcctccttcaggccaggggcagctga ggatccctacccatggccctgacgatcctcttttttctcctgccctctaggccgatacaa agcaggggaaaaggagccagatcccaagacgtggaaggccaactttcgctgtgccatgaa ctccctgccagatatcgaggaggtgaaagaccagagcaggaacaagggcagctcagctgt gcgagtgtaccggatgcttccacctctcaccaagaaccagagaaaaggtatccaaggact ctgggtccttgggaagccctcagggagggagggtagaaggaggtcagctggggctggaga gcctgcaccaaggctgacagcccgtctgccccacagaaagaaagtcgaagtccagccgag atgctaagagcaaggccaagaggaaggtgagtgtggtcctaagcagccaggcctttggtc acctgtgggccagggtgagcagtggaagaaatgctaaggtgggcctgggcctaagctgct ttctccctcgacagtcatgtggggattccagccctgataccttctctgatggactcagca gctccactctgcctgatgaccacagcagctacacagttccaggctacatgcaggacttgg aggtggagcaggccctgactccaggtgagctggtccaggt >IGR2020a cagtggaagaaatgctaaggtgggcctgggcctaagctgctttctccctcgacagtcatg tggggattccagccctgataccttctctgatggactcagcagctccactctgcctgatga ccacagcagctacacagttccaggctacatgcaggacttggaggtggagcaggccctgac tccaggtgagctggtccaggtctggcaggagaccccacaggtcagtgggatgactctttc tcttggaggcatggtgctggcacatggtggcccattagtgcaggctgcagggttggtcgg agggcgctcgatgtcttgcaaactaagaaagcacacaaccttgacctgtggcttctgctg ttccccagcactgtcgccatgtgctgtcagcagcactctccccgactggcacatcccagt ggaagttgtgccggacagcaccagtgatctgtacaacttccaggtgtcacccatgccctc cacctctgaaggttggtgctcctggggcctggcctgcctgcttgactgtctgggtcctgt gaagggcttcctgagagagaaaagatgatcagaactccacctggcactgaattgattgag ttgggcattgcccagtcttagccaccatagggggaggcaagcgacggggacactaggaag gcagttcagagtgggctgcagtacagtgggggctggtgag >IGR2021a tcctggggcctggcctgcctgcttgactgtctgggtcctgtgaagggcttcctgagagag aaaagatgatcagaactccacctggcactgaattgattgagttgggcattgcccagtctt agccaccatagggggaggcaagcgacggggacactaggaaggcagttcagagtgggctgc agtacagtgggggctggtgagaggagggaagggggccaggggctgcattttggggtgctg gttctccttcctcctctgtagcccagcatctgagggtgaggaaggaagtagggtaggggt gggaagcggcgtggcttcagggtttgagaggctgagtcaccaggccagggtcctgttctg gaatctctatggcagataggtccaccgggagggtgtgtgtgtgtgtgtgtgtgtcagaga gacagagagacagagaaagggcagggggatctggtgggctggaactggaactgcagggtg agtgtggctgactgccagccaacctctctgctttccccatccacagctacaacagatgag gatgaggaagggaaattacctgaggacatcatgaaggtaaagccccttcctacctgggca ctcttgaagtgaccgtttctcagtgaggagagagaaccagtgaagcttccaaatcagagg atgggtagctgctgttgtcacctggctgcttgcattgtcc >IGR2022a caacctctctgctttccccatccacagctacaacagatgaggatgaggaagggaaattac ctgaggacatcatgaaggtaaagccccttcctacctgggcactcttgaagtgaccgtttc tcagtgaggagagagaaccagtgaagcttccaaatcagaggatgggtagctgctgttgtc acctggctgcttgcattgtcccacaagtgccacattcacgtggcttgactggtgggaaag ccaccatgggaagggaaggcaggtgggaggcctggcctctgacaggccgtcctgaagcaa gccttggggcatcagacagctctgtgagtcaggcactatcagcgatgggtccctggcctg catcctctgccccaacatgccccagccctgctagttcgggaaatgcacatcaggcttcaa taatcagcctttaggatccgttaatatgatgatggctttatagaaaaagttagcaaatta tcctccaggtttttttttctgcttcagttttgaaagtgaatatagtttttgcagccgggg gcagtggctcatgcctgtaatcccagcactttggaaggcgaaggtgggtggatcacctga ggtcaggagtttgagaccagcctgactaacatggtgaaacccatctctaccaaaaatata aaaattagctgggcctggtggcgcatgcctgtaatcccag >IGR2023a tgcttcagttttgaaagtgaatatagtttttgcagccgggggcagtggctcatgcctgta atcccagcactttggaaggcgaaggtgggtggatcacctgaggtcaggagtttgagacca gcctgactaacatggtgaaacccatctctaccaaaaatataaaaattagctgggcctggt ggcgcatgcctgtaatcccagctactctgaaggctgaggcaggagaatcgcttgaacctg agaggcggaggttgcagtgagctgagattgtgtcattgcactccagcctgggcaacaaga gcaaaactccatttcaaaaaaaagtttttgcagtagttgtacgccagctgttccattagc ccaaaaaattgagacatggatgtcgttccttatctctagcttttctagtcatcttttctt gatttattatgctaacctttgttttaagccacattccctcttactatgtccttacacagt tgagagggaagtcgtggagatgctataccagagagtgggtgtgagaggggtgggaaaatg aattgaggaccagtgccaacatgcatttctgcctcctccctcccgggcccttgtcctgac tgcagtgcacttctgcatcctatctgagattgtgaaaatggccaagggtgtgatactggc tgagaggagctggctcattgagggcagggccacagggtga >IGR2024a atgctataccagagagtgggtgtgagaggggtgggaaaatgaattgaggaccagtgccaa catgcatttctgcctcctccctcccgggcccttgtcctgactgcagtgcacttctgcatc ctatctgagattgtgaaaatggccaagggtgtgatactggctgagaggagctggctcatt gagggcagggccacagggtgagtctgcactggaagggagttgatagcctcttgctcttct gtccccagctcttggagcagtcggagtggcagccaacaaacgtggatgggaaggggtacc tactcaatgaacctggagtccagcccacctctgtctatggagactttagctgtaaggagg agccagaaattgacagcccagggggtaagaaggccctggatccttatggcttcttagatg agggagaaccacgtagggatggagaaagcttgggggcagggccagggagcagggcggtaa agcatctggggtactgacacattgtgaattagctacggctgccatgccttaaggtttgcc tgaagctgagtggatgtttactgctgtgctgggaagagcagaggccatgtctatggcctt caggggtagggggaagcacacctgatgccaccgtcccctaccctcatacaaccttcttca catcttctaggggatattgggctgagtctacagcgtgtct >IGR2025 a cattgtgaattagctacggctgccatgccttaaggtttgcctgaagctgagtggatgttt actgctgtgctgggaagagcagaggccatgtctatggccttcaggggtagggggaagcac acctgatgccaccgtcccctaccctcatacaaccttcttcacatcttctaggggatattg ggctgagtctacagcgtgtcttcacagatctgaagaacatggatgccacctggctggaca gcctgctgaccccagtccggttgccctccatccaggccattccctgtgcaccgtagcagg gcccctgggcccctcttattcctctaggcaagcaggacctggcatcatggtggatatggt gcagagaagctggacttctgtgggcccctcaacagccaagtgtgaccccactgccaagtg gggatggggcctccctccttgggtcattgacctctcagggcctggcaggccagtgtctgg gtttttcttgtggtgtaaagctggccctgcctcctgggaagatgaggttctgagaccagt gtatcaggtcagggacttggacaggagtcagtgtctggctttttcctctgagcccagctg cctggagagggtctcgctgtcactggctggctcctaggggaacagaccagtgaccccaga aaagcataacaccaatcccagggctggctctgcactaaga >IGR2026a gctggccctgcctcctgggaagatgaggttctgagaccagtgtatcaggtcagggacttg gacaggagtcagtgtctggctttttcctctgagcccagctgcctggagagggtctcgctg tcactggctggctcctaggggaacagaccagtgaccccagaaaagcataacaccaatccc agggctggctctgcactaagagaaaattgcactaaatgaatctcgttcccaaagaactac ccccttttcagctgagccctggggactgttccaaagccagtgaaatgtgaaggaaagtgg ggtccttcggggcgatgctccctcagcctcagaggagctctaccctgctccctgctttgg ctgaggggcttgggaaaaaaacttggcactttttcgtgtggatcttgccacatttctgat cagaggtgtacactaacatttcccccgagctcttggcctttgcatttatttatacagtgc cttgctcggcgcccaccaccccctcaagccccagcagccctcaacaggcccagggaggga agtgtgagcgccttggtatgacttaaaattggaaatgtcatctaaccattaagtcatgtg tgaacacataggacgtgtgtaaatatgtacatttgtctttttataaaaagtaaattgttt ataaggggtgtggcctttttagagagaaatttaacttgta >IGR2027a cccctcaagccccagcagccctcaacaggcccagggagggaagtgtgagcgccttggtat gacttaaaattggaaatgtcatctaaccattaagtcatgtgtgaacacataggacgtgtg taaatatgtacatttgtctttttataaaaagtaaattgtttataaggggtgtggcctttt tagagagaaatttaacttgtagatgattttactttttatggaaacactgatggacttatt attggcatcccgcctgaacttgactttggggtgaacagggacatgcatctattataaaat cctttcggccaggcgcggtggctcacacctgtaatcccagcactttgggaggccgagatg ggtggatcacctgaggtcaggagttcgagaccagcctggtgaaactccatttctactaaa aatgcaaaaattagctgggcgtggttgcgggtgcttgtaatcccagctactcaggaggct gaggcaagagaatcgcttgaacctgggaggtggaggttgcagtgagccgagaacatgcca ttgcactccagcccgggcaccaaaaaaaaaaaaaaaaaaaaaacctttcatttggccggg catggtggcttatgcctgtaatcctggcactttgggaggccaaggtgggcagatcacctg aggtcaggagtttgagaccagcctggccaacatggtgaaa >IGR2028a aacctgggaggtggaggttgcagtgagccgagaacatgccattgcactccagcccgggca ccaaaaaaaaaaaaaaaaaaaaaacctttcatttggccgggcatggtggcttatgcctgt aatcctggcactttgggaggccaaggtgggcagatcacctgaggtcaggagtttgagacc agcctggccaacatggtgaaacctcatctctactaaaaatacaaaaattaggccgggcac ggtggctcacgcctgtaatcccagcactttgggaggcagaggcgggcggatcacgaggtc aggagatcaagaccatcctggctaacacggtgaaaccccgtctctactaaaaatataaaa aattagccgggcctagtggcgggtgcctgtagtcccagctactcgggaggctgaggcagg agaatggcatgaaccccggaggcagagcttgcagtgagccgagattgcaccactgcacta cagcctgggcgacagagcgagactccgtctcaaaaaaaaaaaaaaaaattagccgggcct ggtggcgggcgcctgtaatcccagctactgtggaggctgaagcacaagaatcacttgaac ccgggagatggaggttgcagtgagctgagactgtgccactgcactccagcctgggtgaca agagtgagactttgtctcaaaaaaaaaaaaatccttttgt >IGR2029a agactccgtctcaaaaaaaaaaaaaaaaattagccgggcctggtggcgggcgcctgtaat cccagctactgtggaggctgaagcacaagaatcacttgaacccgggagatggaggttgca gtgagctgagactgtgccactgcactccagcctgggtgacaagagtgagactttgtctca aaaaaaaaaaaatccttttgtttatgttcacatagacaatggcagaaggaggggacattc ctgtcataggaacatgcttatataaacatagtcacctgtccttgactatcaccagggctg tcagttgattctgggctcctggggcccaaggagtgttaagttttgaggcatgtgccatag gtgatgtgtcctgctaacacacagatgctgctccaaaaagtcagttgatatgacacagtc acagacagaacagtcagcagcccaagaaaggtcctcacggctgctgtgctgggtagcact tgccatccagtttctagagtgatgaaatgctctgtctgtaccgttcaatacagtaggcac tggcactagccacatgtgccagctaagcacttgaaatgtggccagtgcaataaggaattg aacttttaattgcatttaataaactgtatgtaaatagtcacatgtggtcagtggttacca tattgaacagtgcaggtagatactggactgggggcagatc >IGR2030a tgatgaaatgctctgtctgtaccgttcaatacagtaggcactggcactagccacatgtgc cagctaagcacttgaaatgtggccagtgcaataaggaattgaacttttaattgcatttaa taaactgtatgtaaatagtcacatgtggtcagtggttaccatattgaacagtgcaggtag atactggactgggggcagatctgagggagaggggtttgagtagtgggaggacactgggga taggggcttggggctatttacctgccattttgagtagtttgctattttagcagccaacaa taactattggtgctgaataccagccctgcagtgtagcatgagacaggtccatgcacacat gcattaggaaaacaccttcatgaagcaggattctgcctgggctgatgcacacaacctcta tggagggtaaacagtgtttctgaagaccgtagtttgggaacccctgacatatgacaatgc ccccttagataagctcaagttacaggaatgtctgagggtggaaggtgtggatatgtgctt ttcctgtctccctcttcagtgtctggccatggggcataaacactacccagcagtaggtag gctggccaagagaagccagcttgcatcaccagcatcatctagggaatggaatcatggcag taatacgttgcttaggaaacaaaagctctatggacacatc >IGR2031a ttacaggaatgtctgagggtggaaggtgtggatatgtgcttttcctgtctccctcttcag tgtctggccatggggcataaacactacccagcagtaggtaggctggccaagagaagccag cttgcatcaccagcatcatctagggaatggaatcatggcagtaatacgttgcttaggaaa caaaagctctatggacacatcttccaccttctcagtcccagaaaccatatgtactgtgac cccgctcactaggcccagccctcgggaagagtgtgggcccttgaaaagggaagactgagt gagaaaatgatgagaaaactacaaaatgggcagaggtcagtctgacacattcattctctg tcaagctcaggaagtactggtccctgatcttggagatgctgtgtgagtggcagggggact cctgctgggtaaatattctatatgtggatgcctggacaggcccctatcccaggccctgct tgtcagaagctccccttgggccgagcgcggtggctcacacttgtaatcttggcactttgg gaggccgaggcaggtggattgcctgagttcaggagttcaaaaccaggctgggcaacatgg tgaaaccctgtctctactaaaaaaaaactaaccaggcgtggtggtgcatgcctgtaattc cagctactagggaggctgaggcaggccaatcacttgaacc >IGR2032a gccgagcgcggtggctcacacttgtaatcttggcactttgggaggccgaggcaggtggat tgcctgagttcaggagttcaaaaccaggctgggcaacatggtgaaaccctgtctctacta aaaaaaaactaaccaggcgtggtggtgcatgcctgtaattccagctactagggaggctga ggcaggccaatcacttgaacccaggaggtggaggttgcagtgagctgagatcacgccact gcactctagcctgggcaacagagcgagactctgtctcaaaaaaaaaaaaaaaaagaagtt ctacttggaagctccacttggatttctcaagaatagcttcacctgggaacagaggaatag acaggatggacttttccagctccttcagggaccagccctttttaagatttggattgaggt ggctagccacctgtggcttccatctgggttctcctagtgggtgatggcaggtggtgcaga gcaaggtagagtggactgacgggaggaaagtgataccacccagaacaagcagcagctctg acttctttttctcctgcccttcaatctaatccctgatggagggtaggcagtgagtatgtg aagtcttaggcagctgtggaaatctctcaagttctaaaagcaaagttaattgcttgtaaa ttaccaaaaagagagaggaattatgtccatcagcttccaa >IGR2033a cgggaggaaagtgataccacccagaacaagcagcagctctgacttctttttctcctgccc ttcaatctaatccctgatggagggtaggcagtgagtatgtgaagtcttaggcagctgtgg aaatctctcaagttctaaaagcaaagttaattgcttgtaaattaccaaaaagagagagga attatgtccatcagcttccaatctccacaaccaagatggagtcctcaatttccccatccc ctctgatcccaggagtcctaaatgattggtagcaattgcttggaatctccagggagggac ctcaaaactctcccctggcccccatcacaatggagctgggtcctagggaccaagcctgga gtagtgtgggatagagccagacctttcaggatggagagctgtcccatcacatcctaccaa gacttcagccttttcctaggaaaagaaactaaataaggtctgacagctcacctaaaggtg atggcagctgacactaccgagtcattagccaaacagtgcctgaaacggagcagtattagt aagatctgaaccaagtttgtgcttaataattagatcattctaaggacctgacagtgcttc tgtgggtcattctcaagagtttcagtataagcactaatggtggaagttctaggttgaggg agctaggaggttgttgaaagatctgttttgctggggttgt >IGR2034a agtcattagccaaacagtgcctgaaacggagcagtattagtaagatctgaaccaagtttg tgcttaataattagatcattctaaggacctgacagtgcttctgtgggtcattctcaagag tttcagtataagcactaatggtggaagttctaggttgagggagctaggaggttgttgaaa gatctgttttgctggggttgtgatgagataactgtcatcaaggaccactttccactgggg taaactgacaaaagtggtgctcagccacaccagctagatttctcatgttgggccaagttt acagacatttgcgggcatttgtggttagtcatgggtttccttgccttaactccaaaaggg tatagctggctggtcactttcattgggctggtttattcattcagctcacttggcaatagg aagaaagctagaagctaataggcaaaccatcccttcttggtgtgtcagctttcaacatct ctcagtgcactgtgtgcagggtgttgtgaccattacaactccaaaggaaagagctttctc tgatttttctggaagtctccagtggggcctgccaaagtgggaactgaaatcctggggtag ccctgggaagtggagtttttttctctaggagtgatgtctcctggttggtggggctgggaa acagccaggttgtcattctctgggaccacttgatctttca >IGR2035a ggtgttgtgaccattacaactccaaaggaaagagctttctctgatttttctggaagtctc cagtggggcctgccaaagtgggaactgaaatcctggggtagccctgggaagtggagtttt tttctctaggagtgatgtctcctggttggtggggctgggaaacagccaggttgtcattct ctgggaccacttgatctttcacactgtgtacagatccaaaactctgcccttatacttgga ggggaaagggggtacagatgtcctccaggcagtcctgttggagcacccagggctaatata gtgaccctatagaaagcttttgtctctgtcagatgtaatgctgttccttaacttgggcac aactgatcttccaattcatcagaactcagcactaacctttccccagttctgctggctgtc acagaggaaggaggcctggggtgggagaaggggaagctggtgccctccttttccaggggt gaaagtacttggcagggtggagcttggctttatcatccggagctcccttgtggggccaag tctaaggcctcagaagggtatagctggctggccgcatagttttcctagctccaggcagct ctcaagagacccatttatgctggttttctcagggtaaggagttacagaagtccacctctg ctggctcagtggtaagacacaagcctgcagagtctgctga >IGR2036a gagcttggctttatcatccggagctcccttgtggggccaagtctaaggcctcagaagggt atagctggctggccgcatagttttcctagctccaggcagctctcaagagacccatttatg ctggttttctcagggtaaggagttacagaagtccacctctgctggctcagtggtaagaca caagcctgcagagtctgctgagtgaaacttcagctggggagatactggaggctatggagc aaggacatggggactgaatgaaagaggggaggcagacgtccagcccaccattcctcaccc aaggagatgatcccacaagctcacaaatgagcagaactggaaaagacctcaaagtgtggc tggataatggcaacacaggcctcgagtgctcactttgtgctgggtgctatgccaagcacc acgtgtgtaccacggcactggcaccccaccacggcccttgttcacagaccaggaaaccaa ctctcaccacctaatcagtatggagccttggttccaacccacatcatctatctgtgccca gaatccaggttggttccatatcaggctgcctgagagaagaacacggaggcctgcacaaga agctggggagagctagcaaggggcagggcccgagcaccttatgccaagcaagcacttgtg gatgctgagggaaggcggcaaaagctgcagctgctgtgct >IGR2037a atggagccttggttccaacccacatcatctatctgtgcccagaatccaggttggttccat atcaggctgcctgagagaagaacacggaggcctgcacaagaagctggggagagctagcaa ggggcagggcccgagcaccttatgccaagcaagcacttgtggatgctgagggaaggcggc aaaagctgcagctgctgtgctgccctgccttcagctctcctcccttcccccagcacacac accttccaacacccctggcaacatggctctgccgctacaggccccagggccccaacaggg tagggtttgccccacctatgccctggaggccacctgcagtttcgaagggtggggccccag ggggccgagacacagacaggcttgtaacttggcctcagtgcagggggcagcttggccaca ccaggcctgtttggagcaaacgggggactctggcctgctaggccttatctcagctcccag gatcaaagaggactttttagccatgtttctgtctcagcaagacaacctagtctcctgttc tgctttaaaccagaccctctgttgggtcctggagttcctcagaggtctggaccctggatg gctgtgagactcaggaccatgcacagatgcattctcattcccagccaccaggctcgggtc agaccctatggctctggtgggcctaattcctggtttcttg >IGR2038a gccatgtttctgtctcagcaagacaacctagtctcctgttctgctttaaaccagaccctc tgttgggtcctggagttcctcagaggtctggaccctggatggctgtgagactcaggacca tgcacagatgcattctcattcccagccaccaggctcgggtcagaccctatggctctggtg ggcctaattcctggtttcttgatccctgagaacacctggcacctctggctgctggccagt tgccaccttacatcaggcgggcgctgggattcacctgcaggcttcctttagggaaggccc tcccctgccctcctgtgccagcccagaggggcagcctgggtgaggtcttcacatccattt cgggccaaatgccttggattggctggatcccctcctgtttctgccctccttctttccttc aaagcaacaaggttgtgggggtgtccagttctgctaccacctctccctcacactgtcaat ctggaatttgtccagaattggggcccaagtagtgagttcttacacagtggttaaacaaac aaacaaacaaaaaccccacacaactcagctacaccttggctcagagaggccatgggatat accgaggatctcagatcaggagggaggcccctggagaggtgtggcggggatcatgtgctt ctctggtttcttggagaaagctgactttgtgtaacaaggg >IGR2039a ggggcccaagtagtgagttcttacacagtggttaaacaaacaaacaaacaaaaaccccac acaactcagctacaccttggctcagagaggccatgggatataccgaggatctcagatcag gagggaggcccctggagaggtgtggcggggatcatgtgcttctctggtttcttggagaaa gctgactttgtgtaacaagggaggcatatggacatggagttggtgtttggggatgtggga accattaggccagaattacaagaagtcctgtcatgtcggccacactagggcaacagtgga ctggggcaggggctgatgacctgattgtggaggcagtggagggctgtttctgctggggac ccagggctcccctccaagtgctcctgcttggcttgttgggatggggagaggagctggagt tgggatggggagaggagctggagttgggatgggtcacagcgaaggctacagcctggcatt cccatatggggtaggggtggggtggggtgggacagggaggaggacctgaaggggtgtcca actttccgagacttggaacagcctggtgagtgttcatcaccattcttctgtcataggtgg cgagcagccagagttctgggcacaggagaccatctacccccaagcttgtgcggcctgcct caggtcactgaagaggaccccatttttggtctttggccat >IGR2040a gggtggggtgggacagggaggaggacctgaaggggtgtccaactttccgagacttggaac agcctggtgagtgttcatcaccattcttctgtcataggtggcgagcagccagagttctgg gcacaggagaccatctacccccaagcttgtgcggcctgcctcaggtcactgaagaggacc ccatttttggtctttggccatcctaagacttgtacaatggagccctggggccctcccttc tctgaccagtgacagccctcacaggcaaagcctcaccctctagggcctgtcccttcctgt ctgccagtccccacagggtctgcggggtacccaatctcgccaaccagactggaagctccc caggggcaagcagcttatctcttccatattctcacagtgttcagccaggattggcacttc agagcatctcctgctgctcagcagagatgtagttagcatctctctatagtagcactttct gagtccctcccctgggggaaccaggctagactctggggtccagaggagcaggcaggctga gaggcaaaaagggcacagaggaataaccaaccctgcccctgcagtagagccctgggcaaa acaggccatgaccaaccagcagccaaggtcaaagtccccagaacaagggccagtgtgtgc atgacatgcagcaggaccgcttgtctctttcggcagtact >IGR2041a accaggctagactctggggtccagaggagcaggcaggctgagaggcaaaaagggcacaga ggaataaccaaccctgcccctgcagtagagccctgggcaaaacaggccatgaccaaccag cagccaaggtcaaagtccccagaacaagggccagtgtgtgcatgacatgcagcaggaccg cttgtctctttcggcagtactggagatagaaggctgagtcattaacaactttcttttatt aaaaatgtacataagtaaaaggaacatggtttaattgtgcaaagagtaagaaatacagat gagcaaataacacgtattaaagccacctacgatataccacccagaagtaaccaggctgtt gaatttttagagactggggtgcaaacacattttttcactcccttgtgcatatatctggga gctctgccatatacagacacagacgcggtgtccacaggcgatgcctctgctgggaatgct gcaagcaggagtctatcctttcctggtactggctcgggggccctcctcagcgcccaggtc actctagcatccaggagtccaaaggcccggctgtgcaggctgcagaggtgatctagagta gattaggaggtgcaaaaggcttggagataggctgaccaactgttccagtttgcttaggac tgaggagtttcccaggatttgggactttcagtgctaaaac >IGR2042a ttcctggtactggctcgggggccctcctcagcgcccaggtcactctagcatccaggagtc caaaggcccggctgtgcaggctgcagaggtgatctagagtagattaggaggtgcaaaagg cttggagataggctgaccaactgttccagtttgcttaggactgaggagtttcccaggatt tgggactttcagtgctaaaactgggaaagtcccaggcaaaccagggccagttggtcaccc tccctgagggccaaaggctttgtcctgcccctcctgccctgtgctccccatctgccctcc tgctggggttctggatcccccatccccacaccaagcagcccagggacagaggcctggctg gggccttgcctcccgtggaagctcctgaaagttccagcctgaggcctagggagggacagg ggaaagggaataaattaaggcagacagtctgtcatcacccaagaaaagggccaggtgaac tgtggctgttaagggcagctagggatgtacaagcagaagggttccaatacttggctggcc acccctccagccctggagctgagtgtgtggtccccagaggccccagagccagagaagtgc agggtgtctggattgaaaggcctcagctccctgggctcccagagccctggtgcctcaggc cttaccttccccctcctccatctccacaccccctggcact >IGR2043a tagggatgtacaagcagaagggttccaatacttggctggccacccctccagccctggagc tgagtgtgtggtccccagaggccccagagccagagaagtgcagggtgtctggattgaaag gcctcagctccctgggctcccagagccctggtgcctcaggccttaccttccccctcctcc atctccacaccccctggcacttcctgctcagctcttctctacctaagactgggagcagag gatgaaggaagaggaatccaggacagaccgagctgaaagaggagcaggcaggtgggaggg gacttgggtagaaaggacctctctgatagtggcaggaacatcctgactgtggtctggccc agccggctgtctatgcctgaggatgcctgaggatggggggcccttggaaaactcagaaga gaggctaggtgtggaaggcagagtattggtccacagtggaataaagaggtccacgtccta atgcatgagcctatgaatatgttgctacatggcaaagaggaattaaaactgcagatggaa ttaaggttgctaaccagctcacttgcaaatagagagattaccctggattattggtgtggg cccagtgtaatcacaagggttcttaaatgaagaaggaggaggcagaagggtcagaaccag agagatcgcattgtgaaaaacctgaccagccagtgctggc >IGR2044a tgttgctacatggcaaagaggaattaaaactgcagatggaattaaggttgctaaccagct cacttgcaaatagagagattaccctggattattggtgtgggcccagtgtaatcacaaggg ttcttaaatgaagaaggaggaggcagaagggtcagaaccagagagatcgcattgtgaaaa acctgaccagccagtgctggctttgaaagtggaggaaggggttgcaggccaaggaatgca ggcagcctctaaaagctggaaagggaaaggaaggaaagggattctccactagagccccca ggaagaaatgcagctctgttgacaccttgagtttagcccagtgagacctgttttggactt ctgactacagaactataagaaaagaaacgggccaggtgcagtggcttacacctgtaatcc tagcactttgggaggctgaggcaggcagattgcttgtgcccaggagtttgagaccagcca gggcaacatagtgagaccctgtctctataaagtatacaaaaaattagccaggtgtggtag cacgtgcctttagtcctggctacttgggaggctgaggtaggaggatggcctgagcccagg agggagaggttgcagtgagtcaagattgagccactgcactccagcctgagtgacagagca agaccctgtatccaaaaaaataaataaataaaaaattgtg >IGR2045 a tgtctctataaagtatacaaaaaattagccaggtgtggtagcacgtgcctttagtcctgg ctacttgggaggctgaggtaggaggatggcctgagcccaggagggagaggttgcagtgag tcaagattgagccactgcactccagcctgagtgacagagcaagaccctgtatccaaaaaa ataaataaataaaaaattgtgttgttttaagcccctgtttatgataatttgttagagcag caataggaaactgatccactgggaaaccatttgggggatgcagctgcccaaaatccctgc acgtgggttggactcagcctcacaaggctctacagcctctctgtgaaagactccattccc tctgggagaagctcagactctaaagccctgggcagggaatgggcctccatggcatggagg gggtcaagaaggatgccccccaggatagtgcctctgctggacctctctataggaagcagc tgcctctttgagccccctccccaaacctcagtgagctgaggtgctggctctgagtggtca tggaggggcttgcctgaggtcaggccacctaggacagctagtcagaggccacagggcttg gcttaagattcccaggaaggagttgcatggcccctccacacatccgcaatactcataaca ctctcagtccttggccttactaagggaatactaaggggac >IGR2046a cccaaacctcagtgagctgaggtgctggctctgagtggtcatggaggggcttgcctgagg tcaggccacctaggacagctagtcagaggccacagggcttggcttaagattcccaggaag gagttgcatggcccctccacacatccgcaatactcataacactctcagtccttggcctta ctaagggaatactaaggggactcagtttagctctggaaaagctaggactactggaaaaaa aagtatagaggaaaaaaaatagttactggatgccagccagatctgcaaaaagtccccact ctgccacttactagctatgtggcctcaaataagccactagaccttttgtagcctcagttt cttcatctgtaaaatgggtataacatcatttgtcttatctgtctcacagggtgtgtgagt ctcaggtgagataacacacgagaaaacattgtgccgcacaacttgagatgcaaacagtaa cgatcacaaccccacatgccttttgatagggtgaatgatcacagcatcctgtgttaggga ggaaagggtgagcacagacgcttcaaaactctgtcttacccataggcagaagggtgtagc ctggccaggggagaaaaggacccagccactgccaccgccccgcagctcacaccggatgtg cgacagagccaccatgcagccccacaggatgtcctccaac >IGR2047a cttttgatagggtgaatgatcacagcatcctgtgttagggaggaaagggtgagcacagac gcttcaaaactctgtcttacccataggcagaagggtgtagcctggccaggggagaaaagg acccagccactgccaccgccccgcagctcacaccggatgtgcgacagagccaccatgcag ccccacaggatgtcctccaaccactacagactgtggggctttgctttttttttttttttt tttttttttaagaaaaaggttttctagtttcttctacattaaaaacaatccctccttctc ataaagcacaattttacagaggaaaagggagatgtgaaactatacacaattcaaatctaa ttaatatataatttttttgtggaatacagatggagggaatacatcacaatactaaaggtg attatctttggatggtgggattacaggtgattatatattttttatatttctatagtttaa aaatattccatgatgacctataattacttttacttattttttgagacaaaatctcaccct gttgaccaaggctggagcgcagtggtgcaatctcggcttagtgcaatctcggtgtagtct cgacctcacaggctcaagtgatcctcccacctcagcctccggagaagctgggactacagg tacataccaccatgcccagctaattttttgtagagacagg >IGR2048a ataattacttttacttattttttgagacaaaatctcaccctgttgaccaaggctggagcg cagtggtgcaatctcggcttagtgcaatctcggtgtagtctcgacctcacaggctcaagt gatcctcccacctcagcctccggagaagctgggactacaggtacataccaccatgcccag ctaattttttgtagagacaggatttcgccatgttgtccatgctggtctcgaactcctgag ctcacataatcctcctgcctcggcctcccaaagtactgggattataggtgtgagccacct tgactggcctataattacttttataatcagaaaaaaaattataaataaatatgaaaagtg ccaggaactttcttttgtggagccacacactgggctcaaggaatcatttgagctgggttc tgcaggggtgggagtcttggcgcgggccctggtccttgctgtgtgaccctggagactcac tactttccctccctggcctttgtttgcctggtaagacaagatgctccctagggtcctttg cagcttaataagtaaagtattcgccttggtctcatccatcccagctctttgcccagcttc cagtgactcctctgtgcctggagagaagggcaagcgccttactcatgccttgaggttgct gaccacttccgtcaccagcctcgctccttccagacctgcc >IGR2049a ttgtttgcctggtaagacaagatgctccctagggtcctttgcagcttaataagtaaagta ttcgccttggtctcatccatcccagctctttgcccagcttccagtgactcctctgtgcct ggagagaagggcaagcgccttactcatgccttgaggttgctgaccacttccgtcaccagc ctcgctccttccagacctgccctgggagtccctgcctcctggccttcacctgcatcacgg tctgcacttctcagagccctgcccttccttgaagaacaaagcctggccaaattgtgtcag ccttctggcctgcagtgacccctgcttacattgtacataacaatagctataacttattga cattaacttcaggtcacatagcaaaagtgctctcatttaaatcttaggccaccagaggat ccatagactaaaatgttaacagcatctcctggagttgtggagtgtggtgaccctatgtga tcctcctgtgccactgagagatatattattaacccagtttcactgataagataactgagg ctcagagaggtcaagtaacttgcccatggtcacacagtgggtccatggcagagctgggag gtgatccctagtcagttccctccaagtccaggattttctcactcccacaatggtgtctcc cttaatgactctcacattccagcctctgagggcaggaagg >IGR2050a gatatattattaacccagtttcactgataagataactgaggctcagagaggtcaagtaac ttgcccatggtcacacagtgggtccatggcagagctgggaggtgatccctagtcagttcc ctccaagtccaggattttctcactcccacaatggtgtctcccttaatgactctcacattc cagcctctgagggcaggaagggtatgttctgagttgaacacacagagagcactcaatgat gtctggtggtgaagatgttaatcatgagctcaatcaaggtttatcattaaatcaacaagt cttcctagtgtgtctgggagctctggggcccagggacaggcctactgtagttcagtgttg tattctggcacctggtggtttctggcacatagcccatgttcattaaatgacatgaattga ttgtccattcaaataataaaacaataaataaataatactagctaacaggtatggagtgcc tacaagccagccacctcagggagtttccaggacagttgaggagaaacataacactgttga caagagctacaacgtagggttttacaccaaaacagtgtctacgtaaacagtgtctatcaa agagagaaaaatgatgggcagacaccctgatccttcccacagtgctaaaggccatgccag ccactgtccccattacgacttgcatatactgactgccgaa >IGR2051 a ggagtttccaggacagttgaggagaaacataacactgttgacaagagctacaacgtaggg ttttacaccaaaacagtgtctacgtaaacagtgtctatcaaagagagaaaaatgatgggc agacaccctgatccttcccacagtgctaaaggccatgccagccactgtccccattacgac ttgcatatactgactgccgaagcacacaaacctgaattttccgtctgcatccatcgttct gtctgttcggatcacatctggatactactgttgcctctccagactggataaccagtctgc tgagggccagaagatggtgagatggaaactagtcatgtttacttggagaagagaaatgaa gaccgtctttaacacctgacaggttgctcttcccaagaggggccagagggcaacagccat ggtcaacagctccaggcacccctgaggaagcctgctccagctggcagggttgtctggcaa gggaccagtccctcctctggagaagtggtgagcccagtgggctgcctctccagcaggatc ctgtagagaccttactctctacaatgcacactccacacacttgctcacttgacaaacact tattataactgtcaccctgggcccattccaggttagggacataaggatgaataaaacaag gtctgtaccagtagagaacatcagtcccctaggggagaaa >IGR2052a gagaagtggtgagcccagtgggctgcctctccagcaggatcctgtagagaccttactctc tacaatgcacactccacacacttgctcacttgacaaacacttattataactgtcaccctg ggcccattccaggttagggacataaggatgaataaaacaaggtctgtaccagtagagaac atcagtcccctaggggagaaagtcaggaaagcctcatcctgagccttcgactccttactg tccatcctctaggctcctgtctcagcttctgctgaaggctattttcttccttgtattctg cagtgaccaggcatatggcagataatcaacaaatacaggcatccctgaagagggtatcct gggataaaagccccagctggatcagtgctatacaggggccaactgggggtgggttccagg cagggtcatttgcaagggtccctctgccccttcaagtcctgccagacaggccttggccat ggtttcttcctgcccctgtcccctgaccacagttgatctcccctggctgttatgaaatgt caaagaatgtcctgcaatcctaaattccataatgatctttatcttctgttccctctgagg ctcctcaatctgcagtaacagctgtggttcagcaagcagtgcggcactctggagtgctgt tctgaaacagggccggcgtggggcagagctcatctgctgc >IGR2053a cccctgaccacagttgatctcccctggctgttatgaaatgtcaaagaatgtcctgcaatc ctaaattccataatgatctttatcttctgttccctctgaggctcctcaatctgcagtaac agctgtggttcagcaagcagtgcggcactctggagtgctgttctgaaacagggccggcgt ggggcagagctcatctgctgccctatccattcactgtgctgttcagggctagagaagatt catgtgtgtatatgctttttaaaaattgtgaaacaataattatgcagaaaaatacataga atatatgttcagtttaacaaataatcataaagcaaatctctataaaaccactgctgctct gcagtgacacctgcttccccctaagtcgtgcataacaatagctacaatttactgaccatg aacttcaggtcacacagcaaaggtgttctcatttaatctttggccaccagaggctgcata gactaaaatgtgaacagtgtcccctgcagttgtggagtgtggtgaccctattggatcttc tcacgccactgagggatatactgttttctgtagagaagtccagcagagtcactgtcctgg ggggcatccttcttgatcgcccccatgccatgaaggcccattccttgcccagggctctag agtctgagcttctccaagagggaatggagtctttcgcaga >IGR2054a tcccctgcagttgtggagtgtggtgaccctattggatcttctcacgccactgagggatat actgttttctgtagagaagtccagcagagtcactgtcctggggggcatccttcttgatcg cccccatgccatgaaggcccattccttgcccagggctctagagtctgagcttctccaaga gggaatggagtctttcgcagaggggctgtggagcctcgtaaggctgaatctaaccacgag cagggattttgggcagctgcatatcccagatggtttcccagtggatcagcttcctgttgc tgctctaataaactaacataaacttaggggcttaaaacaacacaaatttcttttcttata gttccgtaggtcagaagtccaaaacaggtctcactgggctaaactgaaggtgtcagcagg gctgcattccttcctgggggctctagtagagaatctctttcctttcttcccctttccagc ttttagaggctgcctgcattccttggcctgcggccccttcctccaccttcaaagccagca ctggctggccaggtctttcatatattgcaatctctctgcttctgcttctgacccttctgc ctctctcttctccatttaagaatgcttgtgattacattgggctcacccaccccagtttct acccaataatccagggtaatctcccaaacttaaagagaga >IGR205 S a tccttggcctgcggccccttcctccaccttcaaagccagcactggctggccaggtctttc atatattgcaatctctctgcttctgcttctgacccttctgcctctctcttctccatttaa gaatgcttgtgattacattgggctcacccaccccagtttctacccaataatccagggtaa tctcccaaacttaaagagagaaaacaatactagcacccccaaagcacctacgtgttcccc tactaatcacaaccccaaccctcccttctgcataagtagacatttgtaataattctgtgc tttttgtagtttgacctcctctgcatgtatccttaacaatacagttttgccagctgttaa atttttgctaaaaggaattatactgtatgcattcttttgtaggttttattcattgatgag tcatttgttattacagtattattatccaatatgacaatattacagttattgcaagtcgct gtagttcatttcactccaggaacactgcacaatttatttgtactctccacttttgatggt catttggacattttctggtgctgtgtgggtattctggtgcacatgggtaagagtgtggtt tgagaagattctgaggagtgggactcttgggttacagggtatatatatgttttcatcttt taaaaaaatttatattattcatttttttaaagactagtca >IGR2056a gaacactgcacaatttatttgtactctccacttttgatggtcatttggacattttctggt gctgtgtgggtattctggtgcacatgggtaagagtgtggtttgagaagattctgaggagt gggactcttgggttacagggtatatatatgttttcatcttttaaaaaaatttatattatt catttttttaaagactagtcactgggcgcggtggctcacacctgtaatcccagcactttg ggaggccgaggccggtggatcatgaggttgggagattgaaaccatcctggctaacacggt gaaatcccatctctattaaaaatacaaaaaattagccaggcgtggtggcaggcgcctgta gtcccagctactcaggaggctgaggcaagagaatggcgtgaacccgggaggaagagcttg cagtgagctgacatcgcgccactgcactccagcctgggtgacaaagcgagactccatctc aaaaaaaaaacaaaaaacaacaacaaaaaaagactagtcaagggcagtagtgagaagggg gaaaagagtagaacaaggagttcgatctgtaactgactgtgaagtcaattgagataattc actaccttcagatcagccatgttttcatctttaccagatcacttatatgctttattttct ttacttatatactttttaatcctgaaagtgtttctcaggg >IGR2057a acaacaaaaaaagactagtcaagggcagtagtgagaagggggaaaagagtagaacaagga gttcgatctgtaactgactgtgaagtcaattgagataattcactaccttcagatcagcca tgttttcatctttaccagatcacttatatgctttattttctttacttatatactttttaa tcctgaaagtgtttctcagggaaacagtggtattacacccagttgtttaggtagaagaaa tggggtatgtctgcccttacagtgtgaccttcccaccttctgtcttcagaaccctgtccc ctccaccccagatagccctgtgccctctggaatccacaggctggcccctcagtagcctcc ctaccttgcagttgggtggggggtgggaggaggtcaagaaagaggaagtgaaaaccaaat acaagggctacagagaagtccggtccacaaacctcaatgtttcagcagcacacgctgtga gaaaggaatgtgcaagctgtttgtggagcatgccttgggggtgccaaggccactggtgca aaggtgtgcttctggacataagtcactccacacaatgctcaccccaaccctgtgaggtac ggtactgtcatccccatgtcacagaatgaagacactgagctgcacggacattgagtgtct gtcaatacagtgcaatggttaatagcatgggatctaggtc >IGR2058a tttgtggagcatgccttgggggtgccaaggccactggtgcaaaggtgtgcttctggacat aagtcactccacacaatgctcaccccaaccctgtgaggtacggtactgtcatccccatgt cacagaatgaagacactgagctgcacggacattgagtgtctgtcaatacagtgcaatggt taatagcatgggatctaggtctgtttaaattgggtttaaattctgacttccccacttact agtggtgcagtcacctgggccattactgacttcctttggtgtcagtttctgcacctgtaa aatggggctaattggctcacagggttgttgagagaggtaaaagatgtaatgtgtagaagg agcttagtcaagtgccaagcacaagggagaacccagtggaactaaaatgagcagagctat gaaatgatgaccattatagagttcaaggttgacagggtggaatggggggttgtcctggca agctgggaccaggccaccaaggtgctggtttggtgctatgtgagaatggaatgctggcca ggtggactctgaaacatggacacctggacagtcctcccactgaccttgtccacctttgtc cggagctctctacctatctgtggctgcttccaaggacggtgatttctgacagaggcagct ggaccttggcacatgcagaagtttcagctcagcatcagtg >IGR2059a aggtgctggtttggtgctatgtgagaatggaatgctggccaggtggactctgaaacatgg acacctggacagtcctcccactgaccttgtccacctttgtccggagctctctacctatct gtggctgcttccaaggacggtgatttctgacagaggcagctggaccttggcacatgcaga agtttcagctcagcatcagtgctggccttcaggaggccgcattggcaggcggcagcagtg acagccaatgggcagcaaagcttgttgctaaggtcactgtgagccttatttggtgacaca gggctgaccctgcattcacctctgagaaccctgggaaacgccaaccacagatgtgaaata tgaacatctcaaaaccacaactgcatttcctttgagaaaagattcggctgtcctcctctc cagcctgcctccctccgctggatgtcttttgtacaatggctcactactgcaagaggcaag agcctaggctacaagaagagtctgctacaagctagtcctgggcaggcctggacagggaga gggcaggggctgctgtgcaggcggccccaggaccttcaaggacctccaagacttccgttc acacccagcagctgccaacccctgcccaggcctcccccaacacagccggagggcctgttc ctggccccacttcctgcagccttgggaagccggctagctt >IGR2060a gtctgctacaagctagtcctgggcaggcctggacagggagagggcaggggctgctgtgca ggcggccccaggaccttcaaggacctccaagacttccgttcacacccagcagctgccaac ccctgcccaggcctcccccaacacagccggagggcctgttcctggccccacttcctgcag ccttgggaagccggctagcttgagaaaggcgtgtggcactcatggaggaagtgggccggc actggggctctcaccatctgcaccagccacaccgcttcggtgcagcctggagctcaaacg gttggcggtttcagtttttcacctccctttggtgcatcttccagcttatcattaaataag taaaactgttgctccaccccagacaaatgtgggagggaagttgtgtcttcaatatttccc aaataacactcactgctccctcccattcatacagcaccttcgggtctgggagctgtgctc acatctgccatctcattacatccttgcaaccctggcaaaggtaatgactgagctcacacc atgtgtcagggacatgaatgaattcacagaattcactgtaattgtccccattttacagaa gagaaaatgagacagagaaattcagtcattggctcaaggtcatcacataactaggatttt ctcccagatggctgagttccaaagtctgccctattctctt >IGR2061a atccttgcaaccctggcaaaggtaatgactgagctcacaccatgtgtcagggacatgaat gaattcacagaattcactgtaattgtccccattttacagaagagaaaatgagacagagaa attcagtcattggctcaaggtcatcacataactaggattttctcccagatggctgagttc caaagtctgccctattctcttctgctacattgcctccatggcacatacacaagaatgagt tccatttactgatgagaaagtgaggctgaggtgaaagggtggtgtggggcctgaggtcag cgttgcttcctcagtccacatctcctcccagaggatggtccaccaacgtccttcatctgc cctccccctttaaaaaccactgtcagcccggcacggtggctcatgcctgtaatcccagca ctttgggaggctgaggtgggtggatcacctgaggttgggagttcgagactagcctgagca acatggagaaaccccgtctctactaaaaacacaaaaattggctgggtgtgatggtgcatg cctgcaatcccagctactcgggaggctgaggcaggagaattacttgaacccaggaggcag aggttgcgatgagccgagatcacgccattgcactccagcctgggcaacaagagtgaaact ccatctcaaaaaacaaacaaacaaacaaacaaaaacactg >IGR2062a ctactaaaaacacaaaaattggctgggtgtgatggtgcatgcctgcaatcccagctactc gggaggctgaggcaggagaattacttgaacccaggaggcagaggttgcgatgagccgaga tcacgccattgcactccagcctgggcaacaagagtgaaactccatctcaaaaaacaaaca aacaaacaaacaaaaacactgtcatgcccccaccgccagcttgtctccctttctttttag gtgtggcccacagagctcagtgccctgcctatctggaagaggctgtgaagcccatctatg taggtaacggaggcaaagcaagggctagggagagtgtgccatgtgggacacctcccccta tcacctccccactgcctgcacacactggggacagtcaaagcattcctcaggctgggggta ggagctgtgggcggaagagctggggcatctgttcacagaatcctcccctgaagttgctcg gaggggctgggatgcagtccagacactggggagcctgatgcagacgcctccctggagcac tgtccttctcttgggctcttcaagcctgccctcactcatgaacacatattttttgtgtgt acttcctgcatgccaggcactacccaggcactgtggatgcacagtgaacaacacagacca ggtccacgcgtcacagactttacttccctgagggaggcag >IGR2063a cagacactggggagcctgatgcagacgcctccctggagcactgtccttctcttgggctct tcaagcctgccctcactcatgaacacatattttttgtgtgtacttcctgcatgccaggca ctacccaggcactgtggatgcacagtgaacaacacagaccaggtccacgcgtcacagact ttacttccctgagggaggcagacattaggcaaataatcacatggatctctgaaaaacata gctcctacgagagggtgcaacttcaggggtcttaacctacaaaggagtgtgtgggattag ggggttagggcagctgttctaaggatgagacatttcaggtgaggagaggaatggggtgga gttggcagtggggctggttctcggctctccccgactgccctccttccccgcattccagtc gcttcaggaaatctgccgcttccatgagagcttctttggtggtgtcttccaagctgctac caagcgatggctttgccagctgttgctttcagtgtttgtgcctgggtgagcacagccggt atgaaatggcccagattaatcgagagccaggcccctcctaaagtacctctgaaaagagtt tttcagcataagcatgacattagcttttcctagagaggaaaccacccccggggctgacag caagcaggccaggcttaaaggaagcaagtgcagcgctggg >IGR2064a ctgttgctttcagtgtttgtgcctgggtgagcacagccggtatgaaatggcccagattaa tcgagagccaggcccctcctaaagtacctctgaaaagagtttttcagcataagcatgaca ttagcttttcctagagaggaaaccacccccggggctgacagcaagcaggccaggcttaaa ggaagcaagtgcagcgctggggcccctccatgccctgctgcagacaggacaccctcactg ccttcccccaacatgctcccccactcccactcctgcttctttctccctgggggactctcc ttgtggaaaagaaaccccaacagtagggggagcgagtgaaactggaaaatgaaactgtga tttacagtttcattttccagtttcaatttagaagcagctctgccagctttccagtgcccg tgcctcagggcatcacagaggagctgaggggcaggaaaaagtgttccagccagcaagcac cctgctccctgggcaccctcagagggcgggtactggactggtagaacccactgagcaggg agttgttgcaatgccgattcctggctctccaggctctgaggccgtacgtttgggcccttt ggtgattctgatgcaggctgtggacctcaccatggcagtcgtggcctcagagaccatcag aacagctagagcacacctgaggcacggcctcatcctctcc >IGR2065a cagagggcgggtactggactggtagaacccactgagcagggagttgttgcaatgccgatt cctggctctccaggctctgaggccgtacgtttgggccctttggtgattctgatgcaggct gtggacctcaccatggcagtcgtggcctcagagaccatcagaacagctagagcacacctg aggcacggcctcatcctctccaagtcacttcctgccacagatgctcgggaagtgctgctt ctctgtgcagcatctcctgccctcctccatctggtgttggaggcatcttagatgttctct gggacctgaggtctgtaggaaaccccggctgtggacttcacacaagggtcgctctttccc acactccaggtttccctttaagctgctaatttgtaacaggcattcatagaaacagaataa gatagagaaattctattaaaggaacttatgtgcttttgctctgtctgttgctccatttat ttgcaatttatagcctaatccaagaggatttaaggacaattaaatatttctttcccctca gtgtgtgtgtgcgagtgcacgtgtaagagtgtgtaggggttgggtcttccaatgtacctt tgccctggtttgaccgtggggggagagggtgggcaggtctccaggcctgccagatgtaga cctttcctaatgtctacagcaaatttgttcttcagtgttt >IGR2066a ccaagaggatttaaggacaattaaatatttctttcccctcagtgtgtgtgtgcgagtgca cgtgtaagagtgtgtaggggttgggtcttccaatgtacctttgccctggtttgaccgtgg ggggagagggtgggcaggtctccaggcctgccagatgtagacctttcctaatgtctacag caaatttgttcttcagtgtttctagtatcagtttttgatcaatcattaatcaaagttgca ataaaaagataatcttctcaggactaggctataaaggtcctggctgcaaccttaaaaaac ccttctgtggaggcctcagagccaagagaaaagggcgatgtgtctgtggctggatttgga ggtaaatgaacgtgctgtccctctctaattggtgtgcacgaacatgaacttcagtcactt gcgtggctatggcctctttcttcatctctccctgccaacgaagctggtggtgccctggct cccaagccaggtggcaaagctggggaaggaggctgtagttgggcccaaatatgggggtct gggggcacctccacaggttgtgaccactgcagcatgctctggggccaggcctatggcagt ggaggcaggacagcccccaggaccacagagcccccatagtggagggagccactacttggg cggctcagctcattcctgctgacttgctgctgtacagggc >IGR2067a ctggggaaggaggctgtagttgggcccaaatatgggggtctgggggcacctccacaggtt gtgaccactgcagcatgctctggggccaggcctatggcagtggaggcaggacagccccca ggaccacagagcccccatagtggagggagccactacttgggcggctcagctcattcctgc tgacttgctgctgtacagggcagaggggtgcctgagacaaagaggagacacacttctccc acgagaaataaagcaagcagctgttcctctcttgggcccagcaggggtcagaggctgtgg gaccttcactccttccctctcagtggagagggcagatctgctctttggggtgtgagggca cagcctcctgacaagctggagaagcaggatttaagagctagaatcaacggagaatgtgag gcccagcatcaggttcaagaagcaaggggatcaaggttgggggggaggcagggagcctga gcctagcgcagcccagaccaacagactgaggagtccagagagccaacatgctcactcggc catcgctaagatgtgtagtgtgtgagaaggtgtgagaggtactcgcgtttctctctccaa ccccttccaacatattattgggtcgtgggtgccatgtttttagtagacacataaaataaa tgagtattttcagagaagtgcaaccctggaggtgcagggg >IGR2068a aacagactgaggagtccagagagccaacatgctcactcggccatcgctaagatgtgtagt gtgtgagaaggtgtgagaggtactcgcgtttctctctccaaccccttccaacatattatt gggtcgtgggtgccatgtttttagtagacacataaaataaatgagtattttcagagaagt gcaaccctggaggtgcaggggagtgaactcagccatgagaaatcattcaaaggattgacc tatggaacagggatagacttgctctccatggctccagcagggaagcagcagagaggggaa cctttcctgaaagtccagtgtgacatctgaagacacacacacacacacacacactttttt gagagagagaacgagaatgaaaagatacacactgatctttcaacagtcgttgtctctacc tggtgattgcgaatgattttaatttttttcctcttgtgcttacagtattttctaaaatct ctaaaatacacccaaattactttcttgttatggcaaaatagacataaaatgtctacatcc attttaaccatttttaagtgcagagttccatagtatgaagtacattctcactgttgtgca gccatcaccaccatccatctccagaactttttcatcaccctcaacataaactctgcatcc actaagcagtatctccctgttcttcctccttccagcccct >IGR2069a ctttcttgttatggcaaaatagacataaaatgtctacatccattttaaccatttttaagt gcagagttccatagtatgaagtacattctcactgttgtgcagccatcaccaccatccatc tccagaactttttcatcaccctcaacataaactctgcatccactaagcagtatctccctg ttcttcctccttccagcccctggcaaccatccttctactttctgtctctatgaatttcac tattctaggtacctcatataagtgggatcatctggtatttttccttctgtgtctggctta tttcacttagcataatgtttttaaggttcatctatgttataacatgtaccagaatttcat tcctttttaaagctgaattatgttccattgtacgtattcaccatattttgtttatccact cctcttgtcatggacatctgggttgtttccaccttttggctattgtgaataatactgcta caaacactggtgtacaaatatcactttgagtccctgctttcaattcttttgggtatattc ctagaagtggaactgcgggatcatatgataactaagtttttgaggaaccaccacattgtt ttcaacaaaggctgcatgattttacgttcccaatagcaatgcacaagggtatctatttct tcacatccttgccaacacttattttcaggttgtttttgtt >IGR2070a atcactttgagtccctgctttcaattcttttgggtatattcctagaagtggaactgcggg atcatatgataactaagtttttgaggaaccaccacattgttttcaacaaaggctgcatga ttttacgttcccaatagcaatgcacaagggtatctatttcttcacatccttgccaacact tattttcaggttgtttttgttgttttaaaatagccatcctaacagatgtgaagtggtatc ttacttattatggttttcatttgcatttccctaatctaaattacgttttaaaatccaatc ctctctgaattgaaccctttgttctttatttctcaataaaatggaccttgcccccttttt ttccttctttgtacctatgctctgcattttaaaaaattgtggcaaaatacatataactta aaactttaccatcttaaccattttcaagtgtagagttcagtattaagtatattcacattg ttgtgccctaacccaaatatagtatataatggcaaaaagaaacaaaaggctctctaaaga aaaagaaagccgtgaattcttggaccccagagatgttcacaaacagattggatcaatctc agcagggactttcattcatcttctgagcatctctgctgggctgggctctgtgccaggcag ggggctccgaggtgagtgtggcctggactctgcccttggg >IGR2071 a tagtatataatggcaaaaagaaacaaaaggctctctaaagaaaaagaaagccgtgaattc ttggaccccagagatgttcacaaacagattggatcaatctcagcagggactttcattcat cttctgagcatctctgctgggctgggctctgtgccaggcagggggctccgaggtgagtgt ggcctggactctgcccttggggttcagcctctgtggggaacagttatacccaagggctgc tgtgggcacagagggacaccctgttgtgtgggtgcggcattgggaaggggcataagtgag gtggcacatgagttcaggtgggaaggatgagcagacatgtacatgtgcagagaagggaac tggcatgtgtggctgggctgtggcagcacacctcacaaccgccattacaggagcatctat taatcatttatgtctgtctctctacttgattataagctgcatgagagcagggctggtggt tttgttcactgctgcattgctgccatgcccagcacaggcaagtgtaaaagaaacacttgc tgaataaatgagtggttgatgacgaggaaaaaggagacatttctttccagaatcttggct gtaagcagcagacagcatggctgtactccacggggaaggcaggatggcaggaagcattat acaggtgatggagacaggagcacagcaggagccagtggag >IGR2072a ctgccatgcccagcacaggcaagtgtaaaagaaacacttgctgaataaatgagtggttga tgacgaggaaaaaggagacatttctttccagaatcttggctgtaagcagcagacagcatg gctgtactccacggggaaggcaggatggcaggaagcattatacaggtgatggagacagga gcacagcaggagccagtggagaagaagagtttgaagattccctggttgagagaatggaag ggcgtaattgctggggagaggtccctgaagaaaggggagaggctgggatgcaggctcagt ggaaggagaggagtctccttatgagactcagatggccagtgtgaaaaagacagaagatac caactgctggtaagaatgggaagcacactgcatggggaactctcctatactgctggaggc gtgttcttcctgttattctagattcagacagcactctggtcgctggttggtgcaggccac catttgggccaattagaggaaccccaatatctgcacttggactatcagaaatgagagctc tacgcccagagcaatttccaagatgggcctgaatccatgagtcatggcactaaatggagc ccagggttggctctgagcctaacagcctccaaaatgtcaactttgttcacgtgccacttt gtccctcatctcatgccatgcagctggcaggacttcagtt >IGR2073a aaccccaatatctgcacttggactatcagaaatgagagctctacgcccagagcaatttcc aagatgggcctgaatccatgagtcatggcactaaatggagcccagggttggctctgagcc taacagcctccaaaatgtcaactttgttcacgtgccactttgtccctcatctcatgccat gcagctggcaggacttcagttgacagaaggtagaccctgctcttttcaaaaagcacacag gacaggtgctgataggccagcccctcccactgagctctagttactgcggtgaacttcacc aggaggttcagcacccactgtggctctgcctgaggggcctctgtgcacactcagtccagg cactagcatcccagcgcccggccagtggtccaactccagactcactacacagagcccctt gcaaccgatgtgtgccaacatggagcccacacagggcagctcagcgtgacacctgcacag ctcaagactgagggaaggaaatgcatcttctttctcaagttggaagaggctgtactgaat taccaaatggcattatactctctgtgggggagcacagatgagtgtccggcagtccctggg atgatgttacagtccagaggtggggatgagatgagcccagatgatgcaatggggatgcaa tcaagacacgatgtcattagaagccacagtgtgttctctc >IGR2074a aatgcatcttctttctcaagttggaagaggctgtactgaattaccaaatggcattatact ctctgtgggggagcacagatgagtgtccggcagtccctgggatgatgttacagtccagag gtggggatgagatgagcccagatgatgcaatggggatgcaatcaagacacgatgtcatta gaagccacagtgtgttctctcatgccacgtgtttcccagcttagaggagtaaggggtcaa ggagggggggggtggccccctgggaccctgctctaggacgcatgcataaggacccacatg caaacgcacagaattcaagagctagccaggcctggacccatgtaggagagccccactggc tgatttccaatctgggacaaaggccacagacaggaggcctcccttggccacacccaggtc cccagaacatatgctccactgtccccagtctaaccacaaccccatatgagctgtgtccca ttcatgttggcctagaaactgggaagtacctggcatggggccctccgcttcctccccatg actgcctggagctctggggagaccaccaaggggccatttttgtggttaggaaatgtctgt ggcagctgtggacaccacaggccctccctggacccttctgaagtagaggtcacattccta aagattcttaactgccagctccaattgcttcttcctgaca >IGR2075a tgggaagtacctggcatggggccctccgcttcctccccatgactgcctggagctctgggg agaccaccaaggggccatttttgtggttaggaaatgtctgtggcagctgtggacaccaca ggccctccctggacccttctgaagtagaggtcacattcctaaagattcttaactgccagc tccaattgcttcttcctgacaggctcatcttagtagggagtgaatataatcttttcccag ttccacgaggtcctctcagatccaaaatgctctaagttcaaaggcaaatcatgaagaaag ggagacgcagatactaatttgtggttttagttcagtggttttccaccttggctacacagt agagttacctaaggagctttttaaaaatactcatgtccaaatattccaacaggcactttg caaagagaagatctaaatggctaacaaacatatgaaaggttgctcagctgtattagtcat cagggaaatgcaaattcaaaccacactgtgataccactacatacctgccagaatggctaa catgaaaaagatagaaaatatctatggttggcaaaaatgtgaagcaaccagaactctcat acattgctggagggagtgtaaatgggtacagccacctgggaacattatttggcataaggt actaaagctgaacatactcatatccatgcttccccagcaa >IGR2076a accacactgtgataccactacatacctgccagaatggctaacatgaaaaagatagaaaat atctatggttggcaaaaatgtgaagcaaccagaactctcatacattgctggagggagtgt aaatgggtacagccacctgggaacattatttggcataaggtactaaagctgaacatactc atatccatgcttccccagcaatggatatacatgtactccaaaaatacacactagcatgtc attgcaatagtcagaatagttccgaattataaataacaactcgaatatccaaaaatgcat cacagtagaatggataaatcgaggaatatccatagagtggaatactctatagcaagaaga gtgaataaactgcagctctaagtaacaacttggatgaatcatctcacaaacacaacaaga ggatatatactgcctgattccatttacatcatataaagtttgaaaacaggagaaatgact gtacaccattagaagccagaatggacattagcctttggagccaggtagtaagtggaaggg gtaccaggggttgctggtgatgttctgtttcatgatttggatgctggttactcggggtaa attcattttgtgaaaattcactgagctttacacttatggtttgtgctttttttttttttt tgcatatatgtcatccttcaacaaacacttaaaaaatgtt >IGR2077a aatggacattagcctttggagccaggtagtaagtggaaggggtaccaggggttgctggtg atgttctgtttcatgatttggatgctggttactcggggtaaattcattttgtgaaaattc actgagctttacacttatggtttgtgctttttttttttttttgcatatatgtcatccttc aacaaacacttaaaaaatgtttgaaaaccccatcaattcagtcagactctttgggtggga gcaagatccaggcatcagtattttttaatatcccagatgatggtaatatgcagccaggat ttaaagtcactggtttaatatcttgggaaaagcagatccactcaagacctcacagggtcc tgacaaaggccacttccagctcagtggagtgagacactggggtgggaagatgtccatttt ttggatgtgggtcagtctcttgcacaggcagaggtattgcagcatgctgttgtaatgtgt atcttccttggcagtgtctgttgaaagctggttgcatcagritgtaatggggtgtaatgg caacaaggtgggcccagccccccccaggaagtggatcactgagcacagcttctacagggc catttgtagagaggtggcagctgggcttcccaggggctgccacccagggcagagccagtg ctgaggctctgacaacctcggcagggtggggagaaggcca >IGR2078a gttgaaagctggttgcatcagtttgtaatggggtgtaatggcaacaaggtgggcccagcc ccccccaggaagtggatcactgagcacagcttctacagggccatttgtagagaggtggca gctgggcttcccaggggctgccacccagggcagagccagtgctgaggctctgacaacctc ggcagggtggggagaaggccagactcagggtgtttatgtttgtgggtaatgacagtcagc tctgggctccagatgatgcttactccctggcctctgtgttcagattaggaacttgcaaca tcttgctgaggaccatgtcaggctcagctctaagtgctgtggctgagaattttccttcct ctctgtgtggttagtggcagcctccctagcaatggctgacctctagcatactctgtcaaa ctacaggcagctgggacaagacaggacatggggctcacagacaggtattccacaacctgg gccctgtcaaccctcccagaaatgcatgggccatgaacctcctgctgtgggaggggcagt gcagagaagtctcaataagcttctcttggccctctgggatctccaccatccacagtgtgt agggctgagctgcaggctgggtcttcaggtggtgtccctgcacatctgctttgcagcgtg gcgtctatagagcaagagtgaacaggaaggggcctcgggc >IGR2079a aaatgcatgggccatgaacctcctgctgtgggaggggcagtgcagagaagtctcaataag cttctcttggccctctgggatctccaccatccacagtgtgtagggctgagctgcaggctg ggtcttcaggtggtgtccctgcacatctgctttgcagcgtggcgtctatagagcaagagt gaacaggaaggggcctcgggcctcctgtagctctgctgggcagggacgctgcggggcctc agctgggcttccttggctaaagggcacagagtggcgtaggctgcaagaggacaagctaag ctgatgaaggctctatcactcaagggtagccatgtaaaaaaaaatccctacaggtaaaag aagcatgaataagacaggcggggcataacagtgtctccccactgaagctgcaactctctg cttcactggcttcagcctcctctctgtgaaatgggggcaatgtcccctaggccttttcct cctgtccagtagggctgagggtctacaggccagagggaggcctgggctctgaggcctgtg cctgtgtggcctctggctgggacctcagcccccatgtgccatgtcacctcccttgtctgt gaaataccacaacagcagctcttgccagccagtgacactaccccttcctgttgtcttctt tacaaagcatttatgaaatgcttccttttcatgcttcagg >IGR2080a ggtctacaggccagagggaggcctgggctctgaggcctgtgcctgtgtggcctctggctg ggacctcagcccccatgtgccatgtcacctcccttgtctgtgaaataccacaacagcagc tcttgccagccagtgacactaccccttcctgttgtcttctttacaaagcatttatgaaat gcttccttttcatgcttcaggaaaccggtggccaggaggagttcttgatttcattttctt ccctagagatatgtgtgcttcgaaatacacaaattaaacaaaaacgagggctgactggga ccaggagagtgagtgatcctggcttcccttgatttacatgcttattttccttctcaaatc actccagtaagtacagaagtcactaatctattgccctctattatctgcattatagttaaa aacatcgacatgaacaaacaaaagcccttgcgtagcctagagaagtcacaaagctcacac ccagactctcgcctaagagagtctctcagggctcactcagggactatttattcttgtttt atttttttaaatgttgataccctctctgcttgagtatccttgttttagatgcaaatcaga aaaggttgctgtattgatcacagtcccagcaggaaacaaatgcacactccactggtaaca ggagagactgaggaaaggaccgtttccaagggtgagcaag >IGR2081a agtctctcagggctcactcagggactatttattcttgttttatttttttaaatgttgata ccctctctgcttgagtatccttgttttagatgcaaatcagaaaaggttgctgtattgatc acagtcccagcaggaaacaaatgcacactccactggtaacaggagagactgaggaaagga ccgtttccaagggtgagcaagatgaagagaaaccctcaaggaaaggtgaagcatcctgca gccagcaacagtgggagctgtgaccaccaatccccagggaggaggtgggagggctcctgg aacccagagagacctgtaggaggggactgccggcaggagctgtggttttagggtgaaaaa cacaggcactattgacctgagacctggcaagggagggagctggggggataaagcacctcc catttcccctcccagcctccaacctctggtcaggggaggggtcttcaattggccaaaccc aactggaagcttggggacctggagcctggctgatggaatccacaaaggtcaaatcctggg aggagtgggaaagagcagaaaatcaactggagcagggatgtgtgggggggtggcaaacaa acaatgcccggcagagtcaccagggctggccatttgaaaagagtacatcagaagctaacg tgctgtaatgtggcactctcaccacaaatacataggatga >IGR2082a tggagcctggctgatggaatccacaaaggtcaaatcctgggaggagtgggaaagagcaga aaatcaactggagcagggatgtgtgggggggtggcaaacaaacaatgcccggcagagtca ccagggctggccatttgaaaagagtacatcagaagctaacgtgctgtaatgtggcactct caccacaaatacataggatgaaaggcagccagggacagaggcggccacgaagaaaggttt aaagaatcccagcaaaatgactggggtcctcattatggaagaacaaatagctttacttaa taattccaaggtaatagcttaatagcttaataattccaaggtaaacaagtattttcataa ggaggactctgaatgatcaacagaaggttaaatgtcactgtactgcttcacagagctgtt acagggcagggaagactataacacaatgtagagatagatccatacaagagaggtacaaca gggtttccagttcaacacatcagttatttacactcctagtttcctttctctcctgaagca ccactaaaatgctagtctagaaatcaaatggggccaggtgcagtggctcacgcctataat tccagcactttggtaggccaaggcaggaggatcattagagtccagaagttcaagaccagc ctgggcaacatagcaagaccctgtcttaaaaaaaaaattg >IGR2083a tcagttatttacactcctagtttcctttctctcctgaagcaccactaaaatgctagtcta gaaatcaaatggggccaggtgcagtggctcacgcctataattccagcactttggtaggcc aaggcaggaggatcattagagtccagaagttcaagaccagcctgggcaacatagcaagac cctgtcttaaaaaaaaaattggctgggtgtggtggtgtgtacctggagtctcagctactc aggaggctgaggtgggaggatcacttgagcccaggagtttgaggctgcagtgagctatgg tcacaccactgtactccagtctgggcgatgaagtgataccctgtctcttaaaaaaatcaa atggggccaggcgcggtggctcatgcctgtaatcccagcactttaggaggatgaggaggg tggattacttgagatcagaagttcgagaccagcttggccaacatggtgaaaccccgactc tactaaaaatacgaaaagtagtcaggcatggtggcacatgcctgtagtcccaggtactcg ggaggctgagatatgagaattgcttgaacccgggaggcagaggttgcaatgagccaagat tgtgccactgcactccagcttgggtgacaaggcgagactctgtctcaaacaaccaaccaa ccaaccaaatggtattaactctcaaaggcaaagagaatgg >IGR2084a agtcaggcatggtggcacatgcctgtagtcccaggtactcgggaggctgagatatgagaa ttgcttgaacccgggaggcagaggttgcaatgagccaagattgtgccactgcactccagc ttgggtgacaaggcgagactctgtctcaaacaaccaaccaaccaaccaaatggtattaac tctcaaaggcaaagagaatggtaaaggagacatgagtggctgaaagagttccccaaacta caggaagctgggaggcaggtggaggaataatgactgacatggaggaagctaggctctgaa gggcttgcagaggggcacactgacaggaggcaagccactttacccctggaaccctgcagg aggagctcagacttggggagtccaggtgttgtggctggtggggctgaggtacagcagcca gtgggggtaatgaatggaggaaactggttgaaatcctccccaggtctcacctccacaccc tgccccacacagctggagacaaagacactgaacaggagagagacaggcaggagggagggc agatgaatacagggatgaaaacagggaggtgagggaaaagtctgaagaatgaagcgtggg actcaatgtcccacccacttaccttgccccgccccaccccaggtatatatcactctggat gagggtatggtgaatttaaaagatggttgcaaattctttg >IGR2085a caaagacactgaacaggagagagacaggcaggagggagggcagatgaatacagggatgaa aacagggaggtgagggaaaagtctgaagaatgaagcgtgggactcaatgtcccacccact taccttgccccgccccaccccaggtatatatcactctggatgagggtatggtgaatttaa aagatggttgcaaattctttgacatttctccaatggagaggtgggtctgtgtctccttcc ttgaacctatgtggatttctgactacagtggaaatgagctatgtgacttccaaggctggg acatacacagccatgcagcttctgtcttgctggccagaacactcacaccagagacttgag gtgcctcgtaagaggtccaatgaccaggccatggtgctggagacatcatgtgtagtctct ctggtcaacagtcccaactgagcccagccttccagctctctttgccaagtgaacaaccat cttacaagtggacccttcagccccagctgttccaactcccagttattccagtcacctcga gtcattccagtcatcctagccgtcgtagagcagagaattgcccttctgactccttgacag tggcccaaaaaatggttgttgttttatgctactaagttttgaggtggtttgttatgtagc gttcaataactagaactaggagttagaatgcttctcttga >IGR2086a gccccagctgttccaactcccagttattccagtcacctcgagtcattccagtcatcctag ccgtcgtagagcagagaattgcccttctgactccttgacagtggcccaaaaaatggttgt tgttttatgctactaagttttgaggtggtttgttatgtagcgttcaataactagaactag gagttagaatgcttctcttgaggagctgaatggcttcagggtggtggttctcaacagggt gattttgtcccccaggggacatttggcaatgtttacagacattttggttatcacaactct gggaggggggttactactggcatttagtaggcagaagtcactggtgctgctaaacattct acaatgcatgagacagcctctgacaacaaggaattctttggcccaacatgtcactagtac caaggttaagaaacctagctctagagaaaaggtgctcattggaggcttgttaactaaaag actgtcttgcttcctgtagtgaaaccccagttgataaattctccccaagcagagtttagt tcagccttttattgctccattaataaataccaacagatagctgagatatttggcatttaa ggaaagcctccaacaaggagagatggagagacagagagagggagaagaaaaagaaagcag aaggaaaaaggaagaaggattaaagaagagggaagaagaa >IGR2087a tgaaaccccagttgataaattctccccaagcagagtttagttcagccttttattgctcca ttaataaataccaacagatagctgagatatttggcatttaaggaaagcctccaacaagga gagatggagagacagagagagggagaagaaaaagaaagcagaaggaaaa.aggaagaagga ttaaagaagagggaagaagaagaacaagaggaagaggaggaggaagaagaagaagaagaa gaaggatgacgacaacgacaacaacaacaacaacaagaagcagccaccaccgccgctgcc acctccaggtagaaacaaaaacaaaatagagactagaagactattaagacaaatggacaa atgaaaaataaatagtgcctcaagaagaataggatggagatagtatatgcataaaaaaga atgtggtatttttgaaaaagaacaggaagaacaagaatgagtactaggatattagaaaaa gaaagccaaaattaaaaaaaaaaatcaacagaagggttggagtatgaagtcaatgaaggt ttcccaagaaagtagaccaaaaaggcaaagagatgaaaagtaggagagaaaatataagga aactaaaacattaatccagatgatccaacagataaaatacagggaagaaaattattaaag aaataatacaagaaaatcttccaggactcaaagatgctac >IGR2088a aaaaatcaacagaagggttggagtatgaagtcaatgaaggtttcccaagaaagtagacca aaaaggcaaagagatgaaaagtaggagagaaaatataaggaaactaaaacattaatccag atgatccaacagataaaatacagggaagaaaattattaaagaaataatacaagaaaatct tccaggactcaaagatgctacataactcagcagtgacgaatatgtccacattcactattg agttaaccacagattgtgttatgttcctattggaaggatggagagaggaaaagtggggat ggttctgtaggaaagttcaatcctcatctatcacaagaagtcaacaaatgcctaaaatcg gtagatcaaaaaatagtataaacagaaatggaaactagtaaatggttgaaagaggcagcc tatagagagggggagtgagaaaggcggggaagggatttttattatgggcttctcagtaca actgatatttaaaccatatgcatgcattattttttattttgtttttaatggatacataat aattgtagatatttatgcagtgcagtgtgatgtttccagacatacatatagcatgacatg atcaaatcagggtaattagcatatctatcaccttaaacacttgtcatttctttgtggtga caacattcaaaatcatctcttccagctattttgaatttgt >IGR2089a gcatgcattattttttattttgtttttaatggatacataataattgtagatatttatgca gtgcagtgtgatgtttccagacatacatatagcatgacatgatcaaatcagggtaattag catatctatcaccttaaacacttgtcatttctttgtggtgacaacattcaaaatcatctc ttccagctattttgaatttgtgcattattttgataaatttgatagaatagaaattaattt aaaagggtacaattttaaaactgcaatgtgatgggatcaaatttaataatttggaaaatt cgcttatgtagaagagtcatgcctctctaagaatgctcaatgaactggcataggtgggca caagcaccatcagcatggaagggttcctcctgatgtcactggccactaaggcagttggtg gggtgagggtggggatgagagccaggcatggcagcccttaggtggtcaccatttccctct cctggcagcctgtatttgcttgggagacctatctcttgggtatagatcctattgggctgc taaagaagagaggtgctaatccttttaggatgacttctgggaattcaccaggatgccctg cctctcctactctggacatggaaaaaaatgctgggtttaccaaaggtggatgagtcaggc ccaggactagagccacggggcctctccctggacgtgccat >IGR2090a ttgggagacctatctcttgggtatagatcctattgggctgctaaagaagagaggtgctaa tccttttaggatgacttctgggaattcaccaggatgccctgcctctcctactctggacat ggaaaaaaatgctgggtttaccaaaggtggatgagtcaggcccaggactagagccacggg gcctctccctggacgtgccatagtcaggctgtctcggcagctaaaagaggctacacacat ttattgtcatcagaagctgggacagatgagccttgggttacaagatctcctacctggagc tctcccgggaggtgccaatcataggggatgggaggacaaacacatgcttggtggggctcc agcgttaccgccgaggtgcatctccttggccactagccctggggtctgacctccccttct cttttccttcacccattgttctccctattccctttctttcccacctctctctcagttctc cagagctctgtgcagggactacttagcaaacttacctgctgaaatgcactgttttttttt ttaaccttttaaattgtcacttttttttaaactataccatccttagataagcaggagata ttccttgtagaaaaataagaaaatattaataatcacccatgattctatcagtcagaaaac tccactgctggtgtatgaatttccagaatgtttccaggct >IGR2091 a tacttagcaaacttacctgctgaaatgcactgtttttttttttaaccttttaaattgtca cttttttttaaactataccatccttagataagcaggagatattccttgtagaaaaataag aaaatattaataatcacccatgattctatcagtcagaaaactccactgctggtgtatgaa tttccagaatgtttccaggcttataaacgggtaaaaatactatcacagtccatgtctcat ctaagcacccagctactgagcaatcatcacctactgggctgtgctgaggcctttagatgt gttaatctctcttaatccttccaacttcacaagataggtgttattgtgccccgtttacag gcaggaaacaagttcagggagatcacattaattgcctgagttcccaagttggttaagaga ctaagctagatctcaacccttcaggctgaatccaaagctactttccttgaatggtttgta agatttttccatttcttttttaaaaaaatggtatgttcaaatatctttctcatcaataaa tatttatcttcatcattcttcctaatgacattcccttgtatgaatgtgccaatgtggaat aaccagttccgtcttgttgggctttcagatgttttctttttgtaaatgataaacaatgca gttataactatctttatatataaactttgcaatagtatga >IGR2092a ttaaaaaaatggtatgttcaaatatctttctcatcaataaatatttatcttcatcattct tcctaatgacattcccttgtatgaatgtgccaatgtggaataaccagttccgtcttgttg ggctttcagatgttttctttttgtaaatgataaacaatgcagttataactatctttatat ataaactttgcaatagtatgagtattttcctagaataaatactggaaagtgaaattgcgt ggtcaaaggccagacacatttttaaaagctgcctctttcccaatcacacatttcccacat ccatttatttgctgaggatcttcacaaaatttggactgagattaaacacagaatcagaga agccctatgctggaaagatcttagtatatacctcttgaactaaaccagtcttactttaga aaaaaaaaaaaaaaaggccaggcgcggtggctcatgcctgtaatcccagcactttgggag gccgaggtgggcggatcatgaggtcaagagattgagaccatcctggccaacatggtgaaa ccccatctctattacaaatacaaaaattggctgggcgtggtggcgtgtgcctgtagtccc agctacttgggaggctgaggcggaagaatcgcttgaacccgggaggcagaggttgcactg agccgagattgtgccactgcgcttcagtctggcgacagag >IGR2093 a gaggtcaagagattgagaccatcctggccaacatggtgaaaccccatctctattacaaat acaaaaattggctgggcgtggtggcgtgtgcctgtagtcccagctacttgggaggctgag gcggaagaatcgcttgaacccgggaggcagaggttgcactgagccgagattgtgccactg cgcttcagtctggcgacagagcgagactccatctcagaaaaaaaaaaaagccctagaccc tctgcagcagcctgctgtgccttcagtgggccaggcagcacttctgggcaagtgaggaaa gggagacccggagggaggtagggaagtgagggcaagagggccatgctgtgggcccacaac caactggcttgggggaggctgctacattttcccaagtgcaacactgtcttcctgagtcta aagacctcacagccatcactgactatactgagctgcctcactgtccccaggactctcact ctatccaggaagtcaacgcaaagtctcttgggccttccctttatccagctgccaacactt agcaccctggtcttccttggacagtttccaaggctacgttgggcagtcccaaacaagatg tggtcttattgttgtcttaccttggtgtgttttcctccaataggctacaaactctggcac ctgcaaaaaacaaggaaagtaaatgattgaagcagggcac >IGR2094a aaagtctcttgggccttccctttatccagctgccaacacttagcaccctggtcttccttg gacagtttccaaggctacgttgggcagtcccaaacaagatgtggtcttattgttgtctta ccttggtgtgttttcctccaataggctacaaactctggcacctgcaaaaaacaaggaaag taaatgattgaagcagggcactgaaggtgggcctttgaacaacgcaagcctggatggaag ttgaaagatgagagcccatctgtggtgagttctttgaaagctgctgaggtgtgagttggt aggatgctggcccagggcagacacgggcacaagcttccacccagcggcattctccactca gagggtttctttctcatttggcctgttaatgctcctatactggcagaaacctcagtgccc ttcccactttgtctcaaggccttgtataaaaaataagttgtcccttcattcatttccatg gatatatccattcatcagctatttactgagcacctactatatgccaggcactgtcctagg gctctgggaatagagcattggactaaaaaggctaacaccctgccctcatggagcttgaag tctactgggtaggggggtggggcggtggtggtagtgaagagtccaaaaactaacaagata cataaattaaaaatataggaatcagaagtggtaaatccta >IGR2095a tatttactgagcacctactatatgccaggcactgtcctagggctctgggaatagagcatt ggactaaaaaggctaacaccctgccctcatggagcttgaagtctactgggtaggggggtg gggcggtggtggtagtgaagagtccaaaaactaacaagatacataaattaaaaatatagg aatcagaagtggtaaatcctagggaggaaaaaataaggcaggagagagaggtaaggaata ttggggcagaaggtgagaaggcgtgtaaaaattctaaaatgtgtgtccagagaaggctag acacctgagaaggtaaattatgaacaaagttacctgaaaaaagtgaggacatgagccctg agaattaacggggaagaagcttcccaggtggagggaatggcaagtgcaacagcctggcag cgagggcctgtctgacatgttaacagataagtgaggagggtggtgtagccagagtagaga gaataagggagaagcaggagagggatcagagaggtagcgagaggctccacagtgttcacg gcattcaagggaggtccttgtgtgaacttgggctctgattctgagacaggagccactaga gggttttttacagagaagtgacatgatgtaactcacattttaacaggatcactctggatg ctgtgttgagaataaactgagagaaagagtagaaccagtt >IGR2096a gagggatcagagaggtagcgagaggctccacagtgttcacggcattcaagggaggtcctt gtgtgaacttgggctctgattctgagacaggagccactagagggttttttacagagaagt gacatgatgtaactcacattttaacaggatcactctggatgctgtgttgagaataaactg agagaaagagtagaaccagttaggaggctatggcagaaatcttggcaagagacaatggtg, gcttggaccagagcagtagcatggaggatttgctgatggattggaagtgagagattaaaa agaatgggtttagaacctgactggggcaggttaaaaagaaaggagctgaagctgtgaact aggagacagagttggctgggagcagcaggaagattcccagttttggcctgagcaactggg aggatggaattgccattttctgaatggaagcgtacagatggagcatgttttgtggggaga taaggaatacggttttggacgtaagtgtgagatgccttttaagcacttaagtggagaaga ctgtaggcaggtggaactgtgaatctggggagaggtccaggctggaaatgagtatttgtg agttctcagcacatagttctttaaagctgtgacacaggatgagatcatcaagagggtgga tgtcaatagggaagctgtcggccgggtgcggtggctcacg >IGR2097a cgtaagtgtgagatgccttttaagcacttaagtggagaagactgtaggcaggtggaactg tgaatctggggagaggtccaggctggaaatgagtatttgtgagttctcagcacatagttc tttaaagctgtgacacaggatgagatcatcaagagggtggatgtcaatagggaagctgtc ggccgggtgcggtggctcacgcctgtaatcccagcactttgggaggccaaggcgggtgga tcacctgaggtcaggagttcgagaccagcctggccaacctggtgaaaccccgtctctact aaaaatacaaaaattagctgggtgtggtggcaggtgcctgtaaccccagatactcaggag gatgaagcaggagaatcacttgaacccaggaagcagaggttgcagtgagcggagattgtg ccattgtactccagcctgggtgacagagcaagactctgtctcaaaaaaaaaaaaaaaaaa agaaaagaaaagaaaagaaaagaaaaaaaaaaaccagggaagctgtgcaaggggctgagc cccattcagtagctcagcaaaagagactgaaaaggactagcaagtacagtaggagggaaa cctggagaaagacttctgaggaggatggcatagtccactgtgatagatcaactatttaat aatatgaagacagagatttagcatcttggagtcacaggtg >IGR2098a aagaaaaaaaaaaaccagggaagctgtgcaaggggctgagccccattcagtagctcagca aaagagactgaaaaggactagcaagtacagtaggagggaaacctggagaaagacttctga ggaggatggcatagtccactgtgatagatcaactatttaataatatgaagacagagattt agcatcttggagtcacaggtgatcctggtcagggatgattcagtggaacagttggagtga gaatctgactacagcaggttctaaagagaggagctgaatttgggagctgagggatggagt tggctggtgacagcaggagggctggaagcagagggagagggatctaacctacattggttc caccttaagagaaaacacaaagctggtacttcctcaacacctgtacgtggccgctgttgt tactaacactgggccaggtcctccagcttgctgagcaccacccaggtctggtcctataag ctagctctccacctgtttctagattcctatgaagttatttcctttttctcactgctgtgt gtagccttaggataaatgcccatagcttggggctgctgagcaagtcctcagttgcttgtt gaccaagatctggcttgggtcctttctcctaatgggaagtcagagtgagcaagggactct gctcttggatagcttgccttctgtgcaggagataaataat >IGR2099a tagattcctatgaagttatttcctttttctcactgctgtgtgtagccttaggataaatgc ccatagcttggggctgctgagcaagtcctcagttgcttgttgaccaagatctggcttggg tcctttctcctaatgggaagtcagagtgagcaagggactctgctcttggatagcttgcct tctgtgcaggagataaataatcaccaaggaaatggatatgcaggcaggtaacttcagatg cagatgggtgctatgaagacagtaagctggggtgaaacacacagagtaagtgtgggagcg acctcctttcgccaggctgtgtggtcaggtgcctctctgggaggtgacatttaggatgac acctagacagcgatgcccagcttattctcctcaagctggcctctcctctgctgctcccag ccttccccgtggcttctacaatatctgcactctgggaacaaggccaaggccttgggccat ctaagtgcaaagccaaa aggaaacaatcctcttctctcgccaatacacaccatgggaact ttttctccatgattacaaaatacgtgcattttcactgaaggaaacttggaaatattgaaa acaggagaaaacgtgtcattctactacccagaaataactacaattaactttggatgcatc cttctagacattcttctatgcatatatataggtatttttt >IGR21 OOa gaaacaatcctcttctctcgccaatacacaccatgggaactttttctccatgattacaaa atacgtgcattttcactgaaggaaacttggaaatattgaaaacaggagaaaacgtgtcat tctactacccagaaataactacaattaactttggatgcatccttctagacattcttctat gcatatatataggtattttttttcttatttccttgggttaaaaatgagatcatgtacatt gtgttttatgatctgaattttgactaaatctgttataaagcactcttctcatgaaattaa ttttcttctacataatgagtttaaatggctgcattaaaagtatttcattatatgtagatt tttaccatattttatttaattcctaaacattggccatttacattgtttcctatgattgtt actaccagcaaatgctctaataaacaatcctgtatatttttccttggagaagggggtttg ccaatctcttatttccttgggttaaaacaaaatgtcactgcccagtggcagtgccatggg tctcatggcagcctgaggctgagggcatgggagggcaggaatgagccccaagcctaagga gccactcagatgccagaggctgatttagtcctatgacatgccaggtcttgagttttcctc ccctgagggcctgatcagtacgaaaacaataggcctctcc >IGR2101a ggttaaaacaaaatgtcactgcccagtggcagtgccatgggtctcatggcagcctgaggc tgagggcatgggagggcaggaatgagccccaagcctaaggagccactcagatgccagagg ctgatttagtcctatgacatgccaggtcttgagttttcctcccctgagggcctgatcagt acgaaaacaataggcctctcccataaacccagagaaatccaaggggattccccacctcag caggaagagggtgtcactctctgaccccagaatagagaccacctccatcctcccttgaaa tcccctggggaagcttctcctgccctccctccctggggaaaacattggcacggtcaggcc ttcaatctctctttggggaggggctgccagggaatgctcaggaaacagaaggttccatag gaatagcagggcctgtcctatccctgacccagccttttccctaaatcctcaaattcccca caggggctggcagggacagtctatgctccccgtaagaggatgtcctgagggctagtgagt tctagggtaaggtgggaggccaccagatgagggtttgaatccaggctctgacattccagc ctcgtcttgggcaagtgacttcacctgtggaatgtgagctacgaggaaggaacttagatt tgcggcccttagcattcaacaggggctctataaataccag >IGR2102a tctatgctccccgtaagaggatgtcctgagggctagtgagttctagggtaaggtgggagg ccaccagatgagggtttgaatccaggctctgacattccagcctcgtcttgggcaagtgac ttcacctgtggaatgtgagctacgaggaaggaacttagatttgcggcccttagcattcaa caggggctctataaataccaggccaggccaatgcatgatcctgtctgagcctcagctgct catatgtgaaatggatgacacctatctcacaggtttgttgtagggactaaatacaactta atacagttaacactctactgtttgagaaacattagagtccaaagccctggagggctactt ccaccacgccccatgctttgtagtctcctctttttggcagaactagtttacctccacact gctactaccacaccctagacatacctctggtgtagtatgcagcacattgtgtgtgtactt gtccaactcctccatgaagcttcagggcagttaaagacaagaattttgcctctctatcgt ctgtgcctctgaatgacactatgaagtaagcaagggcattatttccattctacaaatgag aaaactgaggcttagaaagattagatgccttgcccaagtcacacagtggagagtaggaga gcaagacctaaacctggttctcatttctgggcctgtgttc >IGR2103a cttcagggcagttaaagacaagaattttgcctctctatcgtctgtgcctctgaatgacac tatgaagtaagcaagggcattatttccattctacaaatgagaaaactgaggcttagaaag attagatgccttgcccaagtcacacagtggagagtaggagagcaagacctaaacctggtt ctcatttctgggcctgtgttctgtaaaccaaaaagaaaattccaaggcaccccccagctg tctgaatagacccctcctctcggccaagggcattccaaagttaacctgaaaaactagttt aggccatgatgggaagggggagccagacatgcctcgttataccctcttcccttttggaat tactgactctttaagactgataagagatatttacagtccattctctctgaagcctgctac ctggaggcctcatctgcataataaaaccttggtccccatagccccttatcgtaacccaga cattcctttctgttgctttctattgataataactctttcaaccaattgtcaatcagaaaa atttttgaatccatctatgacttgaaaccacccccactccccaacctagttgtcctgcct ttttggacagaaccaatgtacatcttatatgcattgattgatggctatgtctccctaaaa tgtataaaaccaaattgtggcctgaccactttgggtacat >IGR2104a ctattgataataactctttcaaccaattgtcaatcagaaaaatttttgaatccatctatg acttgaaaccacccccactccccaacctagttgtcctgcctttttggacagaaccaatgt acatcttatatgcattgattgatggctatgtctccctaaaatgtataaaaccaaattgtg gcctgaccactttgggtacatgttctcaggatctcctgagggctgtctcacaggccattg gttacttatatttggctcagaatagatgtcttcaaatattttacagtttgaccgacaact ctattctagatgattctcttgcaaaagggagttggaggtgagaaggaagtgagccaattc tcatgtccctgagaaaaaggcaggcagagcttcgagaggaaggaggtgcttggggaggca gcaggacactgcacttgcctcagccccatcctgactccccgtggatcatcgtgcatgcag cagctgtgacccccagaggcctctagttcagcataagctgaggcaaagggggcccccagg ttccctctactggtgtggagcccagccggcaaggggactggggatcggcggcccagagtt gattgttgtggccccagcagcaggatgatggctgtagagcacctgctcaggagttggcct atctccagctatggggcgggaaggctccctaccagaccac >IGR21 OSa cctctagttcagcataagctgaggcaaagggggcccccaggttccctctactggtgtgga gcccagccggcaaggggactggggatcggcggcccagagttgattgttgtggccccagca gcaggatgatggctgtagagcacctgctcaggagttggcctatctccagctatggggcgg gaaggctccctaccagaccacacacatcttgatgtactcaccctgtgagcccaggacccc tgtgatacctgctgaggtgaaggctgaatgagtgagagctcccagcctccagcatcaggg cattagggagaagaagcagctagactcaagccagggatgcagagggagggaacaggcatc aggtagtaggtgttttaatgtcacctacctcttattatgttgtatgtttctggaggatgg ' gtccatggctgatccatccttgtgtctctactacaaccagcagattactttacagagagt tgatactcagtaagtacagcttattgaaggtgtaaccaaaagccagtaggcaggatgaca gatggcatccgccttgcatgtctgggtcatcagggaaagggccaatgtccagtgtgtcct gaccaggatggttctgacaaggacatccatagcatccacagagggtgctccctccccagg caacaaactctccctccctcctttctttcttccttccctt >IGR2106a cttattgaaggtgtaaccaaaagccagtaggcaggatgacagatggcatccgccttgcat gtctgggtcatcagggaaagggccaatgtccagtgtgtcctgaccaggatggttctgaca aggacatccatagcatccacagagggtgctccctccccaggcaacaaactctccctccct cctttctttcttccttcccttttttttgagatggagtctcacttattgcccaggctggag tgcagtggcacaatctcggctcattgcaaccttcgcctcctgggttcaattgattctctg gcctcagcctcccgagtaactgggattacaggcatgtaccaccatacctggctaattttt gtatttttagtagagataggcttttgccacgttggccaggctggtctcaaactcgtgacc tcagttgatctgcctgcctgggcctcccaaagtgctgggattacaggcatgagccaccgc tcccagcacactctccctttcttagccaaagagacaccacttggaggaaactacctggat ctaggtgcttccctagtgacaaaaatggactggggatgtggtataaatccttgcccctgg gaatctggaagggacctatgatatgagaaaaaacaaacaaacaaacaaacagaccaatta tctctttattgagaccaaaactgctgcttttgcctgaatg >IGR2107a tcttagccaaagagacaccacttggaggaaactacctggatctaggtgcttccctagtga caaaaatggactggggatgtggtataaatccttgcccctgggaatctggaagggacctat gatatgagaaaaaacaaacaaacaaacaaacagaccaattatctctttattgagaccaaa actgctgcttttgcctgaatggtcagattgactgattcctcttccacttgccatccccac tgcatgcatggctacaaataatcctgatgttgcacatttaaaatagtgccttgcttcaac tgcttcagtctatcagtgtaaactgtgtctcccctggcaggtatgctgtgggggacagtg cagggcttgtctctgtaggaccaaactcagtatgaacttatcacctgcctgtgtgtacag ctttaagcttcaggtagagggtgttataaaccctggagtaggacttccctagagaacagg tcattacactatgtccatctattgaggccctaaattaagtctacagaattaggcctaaac tccgcagacagtagccaaaggtctcaggctctggcccactccacctgtccatccacacct ccttctcatcttgcccttcactcacttaacacagtgcccaaagggagatgcagttgcctg gacaggctggctttggcttaagctaggggttcttaaagaa >IGR2108a tattgaggccctaaattaagtctacagaattaggcctaaactccgcagacagtagccaaa ggtctcaggctctggcccactccacctgtccatccacacctccttctcatcttgcccttc actcacttaacacagtgcccaaagggagatgcagttgcctggacaggctggctttggctt aagctaggggttcttaaagaatagtccccagaccagcagcatcagcatcacctgggactt gttagacctcctgaattggaacctgtgggatgagactcagcaaactgttttaatgagtct tctaggtgattttggttgcactaaagtttgagaaccactgggtgagccattccctgagcc caggttgcctttctcagccattttctgcctattataatctcaaccacctttcaaagttca gctcaataccatctcttttgggaagcccccgtagtcccccaagtacttgtgaaggcctct tccttgaaccgacagcttctttgtcaccccatcccccattctagtgaaagaccttcattt ctgcttctctttgcagcatgtattttctgctttgttttatagtaaactttgagcagttgt taactgccttcccacactgattcccctctaacacacaaatgttactctgtaaaggccatg tcttacttcactcattcttttttattttttatttttgaaa >IGR2109a tttgtcaccccatcccccattctagtgaaagaccttcatttctgcttctctttgcagcat gtattttctgctttgttttatagtaaactttgagcagttgttaactgccttcccacactg attcccctctaacacacaaatgttactctgtaaaggccatgtcttacttcactcattctt ttttattttttatttttgaaacaaggtctggctctgttgtccaggctggagtgcagtggc atgatgttggctcactgcaacctctgactcctgggctcatgtcatcctcccacctcagcc tcccaagtagctgggattacaggcctgtgctactgcgcccggctaatttttgtattttta gtagagacagggtttccccatgttggccaggctggtctcggtctagactcaagtgatccg cccaccttaacctcccaaagtactgggattacaggagtgagccactgcgcctggtgcaat ttgctcattctttgaataaatgtccactgaggatctgctctacatggcgggggctgtgct aggcactggggttcagacaaaggtgcacccttatacttatcatccaggagccagtggggt gaatggcaaggtggctggcaattgcaatactttgagtagcactgagacagaatgcttcca accacagggggccccctcatgcccctccctgttgggaccc >IGR21 10a atgtccactgaggatctgctctacatggcgggggctgtgctaggcactggggttcagaca aaggtgcacccttatacttatcatccaggagccagtggggtgaatggcaaggtggctggc aattgcaatactttgagtagcactgagacagaatgcttccaaccacagggggccccctca tgcccctccctgttgggacccacccaaaaagtaacctctgttctaacttccatcaccaga gattaattttatctgtttttgccttttgtttgagacagggtcttgttctgtcgtccagga tggagtgcagtggtgcgatcatagcccagtgcagcctcaaacgcctagactcaagcagtc ctcccacctcagcctcttgtgtagctaggactacaggcatgtgccaccatgcccagctat tttttttttttttaaagagacagagtcttgctatgttgcccaggctggtctcaaactcct ggtctcaagcattcctcctgtcttgacctcccagagtgctgggattacaggtataagcca ccgcacccggccaattttatttgtttttaaacttcatataaatagaatcatacaatgtac ctttcgggtgtctggcttcttcccactacacattatctgtgcgatccatgtatgctgtta tgtatagacacagtttgttcttttttaagattgctgtgtt >IGR2111 a gtcttgacctcccagagtgctgggattacaggtataagccaccgcacccggccaatttta tttgtttttaaacttcatataaatagaatcatacaatgtacctttcgggtgtctggcttc ttcccactacacattatctgtgcgatccatgtatgctgttatgtatagacacagtttgtt cttttttaagattgctgtgttgtatcccattgtgtagatatgacacaatttaaccattct actgttgatggccatttgtgttgtttctagtttggggctcttatggagaaagatactatt agacataagacaaaaacattttggtttatgtccgctggtggacattctggacattcgcac tcattcctcttgagtatgtacctagaggtggaactgatggtttatggaatgggtatagtc ttagctttagtagatactatcaaatagttttccaaagtgattgtaccaatgtacactcct accagcatataaaagtgtttgccaacatttggtatcatcagtcttcaattttagtccttc ctgtgggtatagagttgtatcttttacgttttaatttgcttattggctatttatatatcc acttttaagatgttcctgtttaagacttttgcctatttgcttttttcttatttacttaca ggaattctttggaccttctggatataagccccagtcgtct >IGR2112a tgccaacatttggtatcatcagtcttcaattttagtccttcctgtgggtatagagttgta tcttttacgttttaatttgcttattggctatttatatatccacttttaagatgttcctgt ttaagacttttgcctatttgcttttttcttatttacttacaggaattctttggaccttct ggatataagccccagtcgtctgtcggatatgttacagagaatatcctctcctcttccagt ctctggctcgcctttccactaggttttttgtttttttttttctgagacagagtctcgctc tctcacccaggcfggagtgcatggcatgatctcggctcactacaacctccacctcccgag ttcaagtgattctcctgcctcagcgtcccgggtagctgagactacaggtgcccaccacca tgcccggctaatctttgtattttcagtagagacgggatttcaccatattggccaggctgg tctcgaactcctgacttgtgatccgcccatctcagcctcccaaagtgccgggattacagg tgtgagccaccgcacccagacgcctttccactctttaatggtatttttgatgaacaaaag ttcataaatgttcaatttacccatcttttcatctatggctagtgtatcctgcttaagtaa tcttagttccaagaagtccagttaacagaaataacaaaaa >IGR2113a gatccgcccatctcagcctcccaaagtgccgggattacaggtgtgagccaccgcacccag acgcctttccactctttaatggtatttttgatgaacaaaagttcataaatgttcaattta cccatcttttcatctatggctagtgtatcctgcttaagtaatcttagttccaagaagtcc agttaacagaaataacaaaaattactaatattaaaaaagacaaagaagtgaaggaaaaaa ttggatggtgggtgtgggagaaggactgcatcagatcgtgagagtgtgctcacttgactg tgctgtgcaaagcccgggccttgtcctgtgttgtggtatggatgggagctgaacccccag gcagtgcaacaaacatgccctctgtttggttcagatgctgcgccaggtggtggaaagggc tctgtgggctgtagggggaccctggctcaatggcttaagagaaagatcactccttttcat gtgtgttaagctgggtctgacccccaaaccctggagactccctttagtccaggccctgcg cctctgtgccagagcctgcaaagacagcagtgctgacacttgtccagctggctcacaaag gggaaattctcccctccttgagtcaccacatagacaggaggagcttcaaataacaagcgc tcgactccaaacgatccctatgctcatttcacgatgctgc >IGR2114a acccccaaaccctggagactccctttagtccaggccctgcgcctctgtgccagagcctgc aaagacagcagtgctgacacttgtccagctggctcacaaaggggaaattctcccctcctt gagtcaccacatagacaggaggagcttcaaataacaagcgctcgactccaaacgatccct atgctcatttcacgatgctgcatcactttcaaaatcccctgtgatgcttgtgtatgaagt ctagatccagaaacritccccatgttttccccagtttgagtagaacaataccctgggagt cacaagctacatcatacaattgacttccctaaaaaaaaaaaaaaaaaaagagatcttgga ctcaaggttatgagtttgcagtgtcctttgcagggtcttttaaatcccctagtggcatat gaaactctggatgtttgtgaattttcctggggaaagggtctatgtgtgccatcagattcc ggaaggggtgtatgacctcaaaaaaaggtaagactcactggaccgagtcccctttaagga tagtttgcagtcctcttctgctgggaggtgatggtagtaggcttgccaagaggacctcaa cctaccagatggatgcgatctgccatccacctccccagcataaagccagttcataaagcc agctccagcatctctggggcagttttcttcccatccaggg >IGR211 Sa aaaaaaaggtaagactcactggaccgagtcccctttaaggatagtttgcagtcctcttct gctgggaggtgatggtagtaggcttgccaagaggacctcaacctaccagatggatgcgat ctgccatccacctccccagcataaagccagttcataaagccagctccagcatctctgggg cagttttcttcccatccagggtcaagctcttggcggcttagagatgcagtgtgccagtcc caacaccatggctgtgtgtcactgcagatgaaggcatactttttttctaggacgtgcagt gaccccacttggcagcagacactcatttctgatatttttgtatgccaagtcttgggtaaa acaactaagtgatctcttaaggacccaggttccttttttgtccctgttccttgcccctca ccaccactttttccatgtgccaccctctcataagaactcagaagcccagggtggagtcaa aggggtcttttaaatcccctagtggcatatgaaattctggatgtttgtgaattttcctgg ggaaagggtctatgtgtgccattagattctggaaggggtgtgtgacctcaaaaaaaggtt aagacccactggaccgagtcctctttaaatggaagtgcatggatcagtttgataaaatta atttatagtaatgagctatgtatctttagctaactgcact >IGR2116a tagtggcatatgaaattctggatgtttgtgaattttcctggggaaagggtctatgtgtgc cattagattctggaaggggtgtgtgacctcaaaaaaaggttaagacccactggaccgagt cctctttaaatggaagtgcatggatcagtttgataaaattaatttatagtaatgagctat gtatctttagctaactgcacttctaaaaagacatctgggaagggagaacgcttaactaaa attattattataattattattttttgagatggagtattgctcttgtcgcccccaggctgg agtgcaatggcacgatctcagctcactgcaacctctgcctcccaggttcatgcaattctt gtgcctcagcctcctgagtagctggaattagaggtgcccaccaccatgcccagctaattt ttgtatttttagtggagacagggtttcaccatgttgcccaggctggtctttaactcctga cctcaagtaatctgcccacctcagcctcccaaagtgttgggattataggcatgagccact gcacctgacctaaaattatatttctaatgacaaaactgaggtacagctcataactaaata ggggagaatgacattaaagccactcccatcactaaaaaagaccaatttttctggtctaga tggctttttagaggctcctggagcaggaacaaggggttag >IGR2117a ctcagcctcccaaagtgttgggattataggcatgagccactgcacctgacctaaaattat atttctaatgacaaaactgaggtacagctcataactaaataggggagaatgacattaaag ccactcccatcactaaaaaagaccaatttttctggtctagatggctttttagaggctcct ggagcaggaacaaggggttagtgactacgatgtgtcaaaagagacataggcatttctcag ataaacctcagctcttccggcttgagagaaggaaacattcccaacatgacttaggggccc aaggaccctgtttccacctcatatcagattgtcaaatgggaagggtgtgcctagggcaca cactccctcccgaaagggctgagtccccagaagacctatgtctgctccatcctgggtccc tgctctctcctggagacaagatacagctgcctgtatgagtagcagtctggggcctcctcc tccctccctctgccccaccccactcctccctgcccgcccccatacacactgggttcttcc tcccctgctctctctcaagaagccaggcccctgcccccactcacagtcagaaggaagtga ttctgcaaggcctcccagggactcccaggactggctcaaggcatcagactgttaaataag tgggattttttcagtgtttgtagaaactgttgtttaaaaa >IGR2118a ccactcctccctgcccgcccccatacacactgggttcttcctcccctgctctctctcaag aagccaggcccctgcccccactcacagtcagaaggaagtgattctgcaaggcctcccagg gactcccaggactggctcaaggcatcagactgttaaataagtgggattttttcagtgttt gtagaaactgttgtttaaaaagatgtaaccatccaaactgtttatgtaacccttgggaag tctcaacagatatggttccctatttataactgtggccaggactttaaaaatacaagtgga gggggactgtcaaaatcagagaggttgtcacgttacagttgtatgcttgcataactgaat tcagtattttgctctaatttgagaagtttctttttattcacttttctccttttctggttt tctcttcctttgttgtccactgctgtgcaccatacactcctgacattttctgagaacatc agaactatttctctgaagtggaggttcaaaataggggtttttagaatgaccaaataataa tgaacactaaaattcatttcaaagcctaggactagtctattcatactgatattcctagtc tacaagggtaaacatagctgtcttctcgccgccagcccctacacctgcaggggcctgctc tgtctctgggttgtccgctctggaggtaggtgtcagacca >IGR2119a ggaggttcaaaataggggtttttagaatgaccaaataataatgaacactaaaattcattt caaagcctaggactagtctattcatactgatattcctagtctacaagggtaaacatagct gtcttctcgccgccagcccctacacctgcaggggcctgctctgtctctgggttgtccgct ctggaggtaggtgtcagaccacctggtctcactttcctaggtccaatctctggatctatg gcaacagaatccacaggtccctattcccatacagggggaatgcaaagttgctgggggaca atcacagtgcaaagctgagatctgggcttctttctagagccattctgaggtcttcatcac tcacactaacaatccaactaaaacctggctcttgtaggaacacatcctcttctttattag ggaggctgttctctgagttaacatagtagcagtttcgttcacagatctttctggcaaaaa agaatccgacgagagctatgcctccaccaaaggcacagtttgataacactttggggaagg atggttcatagctcctgaagaagaaagagtctgtgataagaacctctggcccacaggctt cttcacactacacaacttccaaaatccctaaccactgctaatagctaggaggaggatagt gactgttcccaacacaaagagatgacaaacatttgagatg >IGR2120a gcctccaccaaaggcacagtttgataacactttggggaaggatggttcatagctcctgaa gaagaaagagtctgtgataagaacctctggcccacaggcttcttcacactacacaacttc caaaatccctaaccactgctaatagctaggaggaggatagtgactgttcccaacacaaag agatgacaaacatttgagatggtggatatgctaattaccctgatgtgatcactatacata atatgtattgaaacatcattatgtaccttgtaaatatgtataatcattataacacacaat atgaggtcccagacaatgataatacataataattatacgtttatgggatacatagtgatg tttcaatatgtataaattgaagtggtgtgaattatgtataaattttaactacattaaaaa ttacagaaaaataaattttaaaaaacaaaacaaaaaaaattcttaactgctgtcaagcta gcactgacaaccgaagcctcagcccagtacctccctgcttccacctgtgctgaccaccct aagagagaaggcagaggcacacagcccttacatcttggtggggaaaccctagggtttcct ctgagggcctgacagattgaaggggttgaaaatgagtggagggtgtggccacctcagctc tagcctccttctgctgagggacagtggccaaggaacatcc >IGR2121a cagcccagtacctccctgcttccacctgtgctgaccaccctaagagagaaggcagaggca cacagcccttacatcttggtggggaaaccctagggtttcctctgagggcctgacagattg aaggggttgaaaatgagtggagggtgtggccacctcagctctagcctccttctgctgagg gacagtggccaaggaacatcctcatagatccaaaggaaggtggagagtccctctttgtcc tctccacccacctcatccccaccacgccctgatgtcactccctgctgtacccaccccgga aacccttagccacttcccacaggtccactcccagggaagttctttaattggtggatgtgg gaaagaggaagaggaaaaatatcatttctaccttcccaattccctgtatcccatgagcct ccagtctgaaaatgattacccatctgacctggagctctcatcctaggtatcataatggct cttcttttacccataaggagaatgggtaatgaagaaatgcaaaatcccaactcatgaaaa tgtggttgaaaaagggaagacccataaaagttctcatttgttgaccagagacaataaagt gattacttaaaaaaaaaaaaacccacctctggggtctttccaaatcatggagaaaaataa aaacaggggaagacatgctctagtcttaaaactccaatgt >IGR2122a gaatgggtaatgaagaaatgcaaaatcccaactcatgaaaatgtggttgaaaaagggaag acccataaaagttctcatttgttgaccagagacaataaagtgattacttaaaaaaaaaaa aacccacctctggggtctttccaaatcatggagaaaaataaaaacaggggaagacatgct ctagtcttaaaactccaatgtggccccagactggtgagccccaacaacagtaaataccca ccctcagcagccttctgcccacctcaccccaccaatactaggtcccagacaagtcaacaa acacttattgaccatgtactgtgtgcttccaaccattccgggagttggaattctgcaacc tcaaggtgctttgcgaggagcagggaaacagctcagtcaacatttactgtgtgctgacgt tttgctaggtttagaggaggcaaaaatctgagaaaaaaacagctaagaatactccaatct gggaagtactaatatacacatagcaccataggagcaaggaacaattaattctacatggtg aggtcaaccagagaagatgatttttaagttgggccttgaaagcacattaggattttgctg ggtataactgggaaggagtggcattccaggcagaaagaactgagtgagcaaaggtcaggg ttggggttggtatgggcagttggttgtatgtgatacggcg >IGR2123a atagcaccataggagcaaggaacaattaattctacatggtgaggtcaaccagagaagatg atttttaagttgggccttgaaagcacattaggattttgctgggtataactgggaaggagt ggcattccaggcagaaagaactgagtgagcaaaggtcagggttggggttggtatgggcag ttggttgtatgtgatacggcgtgtagtcaggccagtgttgccagaacacggggtcagaga gcaagagcaaaggaggtaaggctaaaaggcaggctgcagtttatggcagccacgaacaca tgccattcaaaggacctgttgcatggagtgcagacagctgacaggctgcagcctcggatc cacaccattcaagtcagaccatgttgcctcctgggtggcccccagccaatgacagaacat ggcagggttgctcgggcctgtccatttctgcccaaagtgcgactcttctcctgggcaatc tttggctggaactccccactgggctcgttgagacactcttacagccgcatcacagtctga tgctctttcaacagaattatccttccctctcttgcgtcccagagttagatctggactgca gtctgaaagctgtcttttctctccgtacttctgctcctttctcctttatctttcataggc attagctcttcttacccccaataaatcttctgcacttttc >IGR2124a tgggctcgttgagacactcttacagccgcatcacagtctgatgctctttcaacagaatta tccttccctctcttgcgtcccagagttagatctggactgcagtctgaaagctgtcttttc tctccgtacttctgctcctttctcctttatctttcataggcattagctcttcttaccccc aataaatcttctgcacttttcattctgttttggtgtctgcttcccagaggactccaactg agaaggagcttagatgaatgtttgggttttgctgacagtgaggagccactgaggtatttt aaacagggcaagccatggtcagatctgagtttcataaaagcaattctagcactagggtga agagccggggggtggggagacagggaagcaacaggcaatgaaaagaccatttaaaaggac actgcactgattggtacaaggtttcaacaaggggcaactggaagtatatacaacttacta tgtatataccctttaactcaacagtctcaattgtagaaatctattttatagaaacactag cacaaatgcataaaagtataaaaatgaggatgtagtggcctataaatattatcaggacat tgaaaaactttgtggtcatctgtaggggaggagatgaactagcagtacatctacgtggtg gaatacataccaagcagcctttaaaaagaagacagcaggt >IGR2125a aacagtctcaattgtagaaatctattttatagaaacactagcacaaatgcataaaagtat aaaaatgaggatgtagtggcctataaatattatcaggacattgaaaaactttgtggtcat ctgtaggggaggagatgaactagcagtacatctacgtggtggaatacataccaagcagcc tttaaaaagaagacagcaggtctctatgtactgtcatagagaaatatacacaatagactg ctatttgtaaaaagccggttgctagccgggagtggtggctcacgcctgtaatcccagcac tttgggagactgaggcgggtggatcacctgaggtcaggagtttgagaccagcctggccaa catggtgcaaccttgtctctactaaaaatacaaaaattagttgggcgtagtggcgggtgc ctgtaatcccagctacttgggaggctgaggctggagaatcgcttgaacctgggaggtgga ggttgcagtgagccaagattgtgtcactgcactccagcctgggcaacagagtgagactct gtctcaaaaaaaaaaaaaaaaaaaaagccagttgctgtacaaagtatatagcatgctccc attttcatgaacaaagctgtgcatacgtatatttataaagatccacatttgtttgtataa ataagtctggaaagagatatatcaactgttgacagaggtc >IGR2126a tgtgtcactgcactccagcctgggcaacagagtgagactctgtctcaaaaaaaaaaaaaa aaaaaaagccagttgctgtacaaagtatatagcatgctcccattttcatgaacaaagctg tgcatacgtatatttataaagatccacatttgtttgtataaataagtctggaaagagata tatcaactgttgacagaggtcacctcttgaaggtggtagggctttcactttttactttct atgttgtttttattttctttggtgcttttctataatatattttctacttcttaaaatgat gaagatggttcatttctcttatcagaacacaaaattttaatttaaaaagcttcatatcta cttagaaaaccatataaaaattctttatattgtatttccagagaagaaataacaaaaatc tcctagaatcgttgagagggctgtcagcggcctggtctcggtaaagagaaattagagatg agttggaatagagccgaacacagggtggtgaagacagaagttccagaagaagccaagagt gctatcttgagtagtgggcaggtgacccacagaagggcggtgggtgggaagtaggagtga gaggggtctgtgctgaatgtgccagccttcaggaggctcaggccaggacagggtgtataa acaagaggtgacgctggctcctgctttagaactcaggaga >IGR2127a acagggtggtgaagacagaagttccagaagaagccaagagtgctatcttgagtagtgggc aggtgacccacagaagggcggtgggtgggaagtaggagtgagaggggtctgtgctgaatg tgccagccttcaggaggctcaggccaggacagggtgtataaacaagaggtgacgctggct cctgctttagaactcaggagagtatttaggcctaaacacttatgacctacaaaagattaa aaacttaccaacagtactcaccaatggactaaaacgctaattgtaaacagtgaagtcatt gaaaaaccagaaaaatattggtgaatacttatctaaggggggaagaattttggataaaag agcaaacagcattttaaagaaattttagccatattaaaaacaaacaccaagactttaaaa acagaactcataaacaaaatcaaaagacaagcaaaaacaaggaattatatttacagcaac actgacagaaaggacatgtccttcatatataaaaaacatatggttgggtgtggctcatgc ctgtaatcccagcactttgagaggccagcatgggtggatcacttgaggtcaggagtttga gaccagcttgggcaacatggtgaaaccgtgtctctactaaaatacaaaaatttagctggg catggaggcttgcgcctgtaatgccagctactcaggaggt >IGR2128a ccttcatatataaaaaacatatggttgggtgtggctcatgcctgtaatcccagcactttg agaggccagcatgggtggatcacttgaggtcaggagtttgagaccagcttgggcaacatg gtgaaaccgtgtctctactaaaatacaaaaatttagctgggcatggaggcttgcgcctgt aatgccagctactcaggaggttaaggaaggagaatcgctggaattgaggaggcagagttt gcaatgagctgagattgcaccactgcactccagccaaggagacagagtgagacttcatat aaaaaaaaaagcaaaaaacaaaacaacaacaacaacaaaacccaaaaaacacagatgagt ttgtaatcagtaataaaaatacactctccaaagaaaaacagcactggagctgggcatggt ggtatgtgcctgtaatcccatctactcagggggccaaggtgggaggattgcttgagccca ggagttcaaggccagcttgggtaacacagcaagatcccatctctataaaaaataagttag ccaggtatggtggtgcacacttgtagttctagctactctggaggctgaggtaaaaggatt gcttgagcccaggagttcgaggctgcagtgagctatgattgtgccactgcgctccagtct ggttgacaaagcaaggccctgtctcttaaaaaaagaaaga >IGR2129a ggtaacacagcaagatcccatctctataaaaaataagttagccaggtatggtggtgcaca cttgtagttctagctactctggaggctgaggtaaaaggattgcttgagcccaggagttcg aggctgcagtgagctatgattgtgccactgcgctccagtctggttgacaaagcaaggccc tgtctcttaaaaaaagaaagaaaaagaaaaacagcattgattatggtattgtgtattata aacattattttgtattggttagaattttgttcagttacataaaacagaaaacaatagtgg cttaagcaagatgggattttctttctttctctcactgaaaaaaaaggtctagaaatgatc agttcagggctggtttggtgacttcaggtgtcaccagggacctacgcttcttctggctca tcctgcccctattcctaaagtgcagctctcattctcatgtcttgtggtagttgctagagt gatagtcaccacatcctcatttaagaaagtaggatggagaaaggagggtgaataaagggc acaccccctcctgttaaggagctggcttcgaagtcccatatgacacccacttgcatccat tgtccggaacccagccacatgatcacactttgctgcaaaattgccaggggaacgtagttt tcagctgggtggaaaagggatcagcaaaaaattggttttg >IGR2130a tttaagaaagtaggatggagaaaggagggtgaataaagggcacaccccctcctgttaagg agctggcttcgaagtcccatatgacacccacttgcatccattgtccggaacccagccaca tgatcacactttgctgcaaaattgccaggggaacgtagttttcagctgggtggaaaaggg atcagcaaaaaattggttttgttactaagaaagagggaatggatactgtagagcaatgag cagtttctaacatacatgtgaacaaaattatcaaaagaaatacaaatgtaaaagatttca gggtcaaccttaccaacagtcaaatataagtaaagcaggtggccttttatggtcttgtct ggctaaggtattgaagagctggccagacaagtcatgaagacagtcaagaactgactgtct tcataaggaccgactgtcttcataagaaccttgggacaatgcacatgaacagaacagagt ttcagggtaaaaatggccctttctccccaactagatggctcaaggacccaagggccactt cctggctgttcccccaaagtctccctccaactcccaagtgacatcagattctgtaaatgc tgggaagtagagaaaaattctgtacccagggattctctaactaaactatggctaaaatta aattttaggtgtttttgaaagttcctttaaaaaagtaata >IGR2131a tttctccccaactagatggctcaaggacccaagggccacttcctggctgttcccccaaag tctccctccaactcccaagtgacatcagattctgtaaatgctgggaagtagagaaaaatt ctgtacccagggattctctaactaaactatggctaaaattaaattttaggtgtttttgaa agttcctttaaaaaagtaatatcctcatgcaaactgaatcagcagtttcagaacttaaaa aaaaaaaaagaacctctgtcgtattcttggggtatcacaaattaaacatgaaaaccagcc actaaaataaggaccagtgtttggatactacatgggggtgatgttaggcaacctcaagtt atgtcttttggcagattcaggactttatgtgagctcccacagatggtgatgtcaatgcca ccacccttcagaaggcacagagaaggaaagtgcagaggacacggcaagtgtggattccac aggcttctgaagttcataggcctattttgaatagttattgtgcctttctcaatccagacc agcatcagttacctctcacgatttatttgaaagcatttacttctagtgtttgctcttttt aaatggttgctgattgggaaaaataccagagtaaactgatgtttcatgaagtctggggga gacgatctttagggcatgggaagcaatatgatataatgac >IGR2132a gcctattttgaatagttattgtgcctttctcaatccagaccagcatcagttacctctcac gatttatttgaaagcatttacttctagtgtttgctctttttaaatggttgctgattggga aaaataccagagtaaactgatgtttcatgaagtctgggggagacgatctttagggcatgg gaagcaatatgatataatgacgaaacgtgcccatgctttggaatcagaaacacctggatt tgagacctagctctgtggtttaccagctgtgtgttctgggacaagttattaaacttctct ggggctcaggttccttgtcttaagatgggctaatacagtgcttacctcgttgtatcatca agttgggtaggaaacagatggtgaacttggactgggactgtttacaaaggtgtggggagg gctcagggaaatcaagatgagacagtgaagcatatgggggctagcaacaatggggagctg ttaccacttgtaacctgaaggtatgaaggaagggaataaatgggtaaggggacccaaagg aggcagctattggaagggtgtctggcaggagctgtgggctccagtggaggatgcagttgg cctaaagcgacctgatagggacccgggggaataacttaaccacttgccctcctcggggaa ctcctgacctcatcttcctgagtccttccatctcttgcta >IGR2133a ggtatgaaggaagggaataaatgggtaaggggacccaaaggaggcagctattggaagggt gtctggcaggagctgtgggctccagtggaggatgcagttggcctaaagcgacctgatagg gacccgggggaataacttaaccacttgccctcctcggggaactcctgacctcatcttcct gagtccttccatctcttgctaatgctccccatggaccaaatctaactagaatccagaggc aagatagatgagtgatgtggcccattcaggtcagcctcccaacccagagcaggtagagag gacggagagtggatctgcaggagcaaacagaagattaatcaaaatagagactgtgatgag gttagcataatgcctggaacatagtaagtccacaagtcctcaacaaatgttaatttattt tggactttggactctctgtctgcctgttttgcttattgcttacttcctggttttcatcag ctcatgtatagttgagataacttccaaataatcaagtattgttatctatattggagtgtt ttgaaggagtaatgagtgtataaaaaagataaccagatactctggggattagagatgaca gagggaaacagaggaaggggagtaagtaagagaaaaggatggagaaaactgtatgttccc tatgaggctggaatgaacgcaagattatcttactttaaaa >IGR2134a acttccaaataatcaagtattgttatctatattggagtgttttgaaggagtaatgagtgt ataaaaaagataaccagatactctggggattagagatgacagagggaaacagaggaaggg gagtaagtaagagaaaaggatggagaaaactgtatgttccctatgaggctggaatgaacg caagattatcttactttaaaatcaaatcatgcacttattgggatgtgataacagtgcgtt tgcaattttacagcccagtgagacttgccagaaagggattttgcaaggaaggtcttcctg ccctaaaggaaaacctagtgcttacttccagattaataagtcttaacccatcatgcctgc tcccccaaaaccaagtagtcaaatgtgttaacctggatgtttaaatacctgcatgttcct gcctgggtgcctgggtcaggtgaatgttctattctgatttgggaaatggctagagtgtgt tggtcgtcgcctgggatagctcccaggtaggaagggagccccagagagtggtctgaacag tgactcataaactcagtgtcctttcctccagcctttaccagctgctgacttggcccctta ggaatctgtcttcattccgcaagctattctccagtgtctggttcaggctctagagcagag cattccaggctttctgtgattcctggccacctgttccatc >IGR2135a ctcccaggtaggaagggagccccagagagtggtctgaacagtgactcataaactcagtgt cctttcctccagcctttaccagctgctgacttggccccttaggaatctgtcttcattccg caagctattctccagtgtctggttcaggctctagagcagagcattccaggctttctgtga ttcctggccacctgttccatctccaagaccctccagcatccttctctcatttgcttaccc taccctccaggcctttgcacaggccactctctgtgcctgggacatacattctccttctgg ctaaccttccgcagcctccaggacctctcaggtgtcctctcctctgggagccctgctgga ctgcccacggggagttgggaagcccttctgtatgctcctgttagccctctttgattctct cactcacagcacttccacactgtcttggtttcctggctcatctctcccaacacactggac accccttgagaagagacttgacatattcatcttgattttaatgccatccggcaaaattcc tggcactcagagggcatgcaataaaactttactgaatgaaggtttagcgcgtaattcaga aaataagcaagaaagtgtcacaaacaccaaagcaagttaaccaagctatatgttctagaa cattcttcctctcctcctgtcactctggctctcctgcgcc >IGR2136a gacatattcatcttgattttaatgccatccggcaaaattcctggcactcagagggcatgc aataaaactttactgaatgaaggtttagcgcgtaattcagaaaataagcaagaaagtgtc acaaacaccaaagcaagttaaccaagctatatgttctagaacattcttcctctcctcctg tcactctggctctcctgcgcctacagcagacaggacagagtctgctctttcacctgctct tttctagtcttttctttcaggtatcccctgaaatgccacttcctcagaggctatccttga ctacccaatccaaagcagtcactcagtcacttgattacacttcagtctattttaatttgt tagagagcacttactgctagcaccaatgttttatttctgtgttttctttctatctccacc attatgctgtagctccatttgagcagggaccttgtctgttcactactgtatgcccagcat ctagtacagtgtgtggcagagagtcaagtgttcattaaatacttgttaaatgaatgcatg ccactgttactgcatgctgagttaatttgatgtatggcttctatcactgctatcagatta ggtgctctagagaaactcagaaagggctgagtctccttatgacattgcagggtgggaggg ggacctcagttcccttcctaggcctaagtgggatatgctg >IGR2137a agagtcaagtgttcattaaatacttgttaaatgaatgcatgccactgttactgcatgctg agttaatttgatgtatggcttctatcactgctatcagattaggtgctctagagaaactca gaaagggctgagtctccttatgacattgcagggtgggagggggacctcagttcccttcct aggcctaagtgggatatgctgcctgcttgcagcttccttgtggcctggacttccccatgg aggccagatgctgagcaaccccagcccatgtgtctgaaggctctgaataccgaaatgttc ctctagctttctgtgagagcagttggagctgcccattgcctacactgatagaggaatgtg cccagggctcctggctggcctggcacccagcaggaggcaggcacagtggccagcacggtg aggacacatcacacttcttctttttcccatatccctatgctgagagtgcatgcagctgcc tggctgggagcagaaactggcctcactttctggggcctgctgggcagacaatgcagctct ctagctgtgccacagaacagggcaaatctttactagctgtggactcactccctgcccctc ccattcctgcagaaattgctctaccagctcagcagagggccaggtctggaatctctcacc tgtccctggcccttcctttaagccctctggtttactggaa >IGR2138a gcctcactttctggggcctgctgggcagacaatgcagctctctagctgtgccacagaaca gggcaaatctttactagctgtggactcactccctgcccctcccattcctgcagaaattgc tctaccagctcagcagagggccaggtctggaatctctcacctgtccctggcccttccttt aagccctctggtttactggaaatcataaactgtgagacacagcctttatcacaccctgaa cagttcactcttaatatttaatgctggaggctaaaacaaccagggacactggaggcctcc tgcttactctcagtgactgatgtttgcacctggtaattgaggtcaggttgcttctcttaa gtcacatgatttgcgtcaaagcaggaaggtgtcggggccacttgttgcaaagagaccagg aggcgatcccagcaacgctgcaaaccagctttggcagcaaaggctgtgctttcatgggag ccagccctaggagtgtggagctgggctggcagctggtaaatgaccctctcggggcctgaa taaaccctagcttttcactcacagcaaactcaggatgccttcctccctctaaaagacctg ctgaattgagtcactttcaatcctttctggagtaggatggggcattagttaattaacaaa ttaattaagcatgctaaatagtcacccagaagatactggt >IGR2139a gctgggctggcagctggtaaatgaccctctcggggcctgaataaaccctagcttttcact cacagcaaactcaggatgccttcctccctctaaaagacctgctgaattgagtcactttca atcctttctggagtaggatggggcattagttaattaacaaattaattaagcatgctaaat agtcacccagaagatactggtcacttaagggtctccaaatcacagtataggtcccaccct acccagacacctaatcttgtttcagggtttgcttgacctcaggcatttatctcctggttg tcatggaatctgctcagataaacagcagcacaccaacctggcccctctgccagcctcaga tccttctaaggcagtggagctccctggtggccaccagccacccgggctccaggcagccca acacacactcccatgctgaggtctctcgcatgacctctctaggcacacagtaggtgctca gtaaatgctgtggcatgaaggaccctcctggagtgtctgagttctcaggcttcaaggccc ctagataagcagatttctctcccctatcaccatagtcaccccagggactgcagggcaggc cgaaatcagccagtgactcagctccttgggcaattcagctggcccacagaccacttcctc tgctccccagcgccggatggatgcagatctgtgagtaagg >IGR2140a ggaccctcctggagtgtctgagttctcaggcttcaaggcccctagataagcagatttctc tcccctatcaccatagtcaccccagggactgcagggcaggccgaaatcagccagtgactc agctccttgggcaattcagctggcccacagaccacttcctctgctccccagcgccggatg gatgcagatctgtgagtaaggagccagctgcaggcaagcagctcgagggcaggtgggcat gatgtctggctaccactcgcactggacgccacacacacagccagggtggcagaaggcccc acctgccatgtgccagtgggacaccaccctcatggtctgcgtttccaggtttccaactaa ggactgagcacactctcaacatggacctcctaactgctctcgaggatggacagctggcct caagggaacactgcaaagtggctctaggaagaagccactgtccctccagaccataaaaat ggctaccaagggcagagccagcagctttcgctgtaaagtttctcaagaaaatcacagata ttcccctctgtgatgttcagctcagcctggaaaggaggtaagaaagaccagactacctga tctctcaaggtcaccaaattcaaccactgtcctgtttaaaagcgggtagtacagaggcca gtgtgggctctggaatgagacatgtgaagcccgggtctgc >IGR2141a agcagctttcgctgtaaagtttctcaagaaaatcacagatattcccctctgtgatgttca gctcagcctggaaaggaggtaagaaagaccagactacctgatctctcaaggtcaccaaat tcaaccactgtcctgtttaaaagcgggtagtacagaggccagtgtgggctctggaatgag acatgtgaagcccgggtctgctgggtctgctgcacggtagcagtgtagtcttaggcatta ttgaaactctgtttctaaatctggttatgtgaatgaaaggggctaatttatgtaacactt ttagtatactaagccctcaatatagtttagctacttaactattgtcttctttgaaggacg ctgaactaaacagaagagaaacagggaaataaacagcatggcaacctacatcaacagaaa cttaattattcaccctggataactgagtgtgtgagtgtgactgcaaataacaatatagca aagagaagtttgagatctttggctcagtcattctagaatcctgagtcacagcaaatgcac agcctccatgaggctgagccacacatgaaagctgcttccacccacagactggtagaggcc actgacatgcttaacgatgatgatgatgataaaaatagctaccacgggctaccacgtgca cacacatgttaagcagttcaaacaggttattttgtttaat >IGR2142a tggctcagtcattctagaatcctgagtcacagcaaatgcacagcctccatgaggctgagc cacacatgaaagctgcttccacccacagactggtagaggccactgacatgcttaacgatg atgatgatgataaaaatagctaccacgggctaccacgtgcacacacatgttaagcagttc aaacaggttattttgtttaattcataccacaaatctttgaggtaagtattcttgttcccg ttttatagaggtagaaactgagagttgaagaggctgaataatttctcaagcacactccca actcgaccacccacaagcaaaaaggcagagctgggattcaaacacaggtatgactgtgtg tggacatctcccctgtgctatgctccctgaaggaaaattctaagtggtgttgtttctggg agaaatctacctgtgtggtctttaaacctactctgacaggagcaagggccaccactctgt atctaagaccactgggaacagtcttcaggcaacaaggtgaccagggcagctgcagagggt atctatgcccctgccccctagcgcaaaagtctgtttctctttccaaatggcccgctggga gcaactatttagggagaccatacctcctcccacactcagttcccaggcctgagccacaga gtcctgccacaggagggaggacctgcctgtcctgctccct >IGR2143 a agtcttcaggcaacaaggtgaccagggcagctgcagagggtatctatgcccctgccccct agcgcaaaagtctgtttctctttccaaatggcccgctgggagcaactatttagggagacc atacctcctcccacactcagttcccaggcctgagccacagagtcctgccacaggagggag gacctgcctgtcctgctccctccccactccaggttcctggaggcctctgtgatgattccc caggaaggactacaggatctggcaggcagcaggtggcggtgggaggaggagagtcctggg agcacagcactcctaaccccctctgcctctcacagaacaaagagggagtcatgccatgtc ccctgctcccacaaatgccccacccagaggggctaatgcctaggattgagggtcttgtgt gctgaggaagtcctgtcccccaatcccctacaaaagccagaaccagctactaaggggtta gacacagacagaactgtctatattaacatttcctcctaaaaaacaacaggaatcctgggg aaagaccactggcctgggactccatgagccctggcttctatctctggctttatcaggtga ccacaggcaagtcacctagcctccatggtctaggccctcctgcctgttgggtgggaatca ttacatatcacaatcattacagctgaccttcagggaggct >IGR2144a atattaacatttcctcctaaaaaacaacaggaatcctggggaaagaccactggcctggga ctccatgagccctggcttctatctctggctttatcaggtgaccacaggcaagtcacctag cctccatggtctaggccctcctgcctgttgggtgggaatcattacatatcacaatcatta cagctgaccttcagggaggctgtactctgggtcaggaattgtgttgggtgcattatcata tttattctcacagcaccctttgcagtagctactattttcatacccattctcagatgagga aactgtggaacaggctggttaggggacatgcccaaagtgacaaacttagcaaaggtggac ctggcactcagtaccacatctgtttttccatgctcttaaccactgtaacatacagagccc ttttacagagatcaaggacagaggtaaaagtgttttgaaagcaaaaaaaaaaaagcgggg aggatgcataaaataaacataaatcaccccctgccccgcccagacataattcagggaaga gtcctaacccccaagaaccttctgtggaacttattcgcaacatcagagacctccaacata gaaatgaccctcaataagtcatttctttcttcctctttcccttcaggcaggaataatata actaactgaattatacaggtgagaccacgaaggtcaagca >IGR2145 a taaatcaccccctgccccgcccagacataattcagggaagagtcctaacccccaagaacc ttctgtggaacttattcgcaacatcagagacctccaacatagaaatgaccctcaataagt catttctttcttcctctttcccttcaggcaggaataatataactaactgaattatacagg tgagaccacgaaggtcaagcaagggtgaccagcttaggcccctggctggcaggtaaggag gagactgaccccagcctcctggctcctaggggaggaaacagtgatgacaaaggccccttt gcatggccaaggtggagccctttctaccaaagtttaaacgttttagtataatatccaagt gcatcttttccaaccttaaaaacatatttaatttccttataaagctggttggcactctcc tcctcctccaaagctctgtattaggcagggttcatagttgtagacaacagaatgaacagt ggttagttcagccagaaaagggatgatataggaggatactgggttgatcaaaggctctct gggagggctgcagatttagagccagtcagccaggaacgatgcctgaaacataccttagag ctggagaaagaacaaaaccctacctttcttcaatagctggcaaggtggcaaggtctggcc ccatgcagcctgggctcttcccactctcctctctccctaa >IGR2146a gggatgatataggaggatactgggttgatcaaaggctctctgggagggctgcagatttag agccagtcagccaggaacgatgcctgaaacataccttagagctggagaaagaacaaaacc ctacctttcttcaatagctggcaaggtggcaaggtctggccccatgcagcctgggctctt cccactctcctctctccctaatgcgttgccctactcgctgcttcccaggcaatcccacct caggtctatgaacttgccattccctctgcctgcaacctagacattcacattgctagctcc ctggctagctcaaatgccaggtttctgcacaaatgctcctccttagagaggccttcctgg acctctaggtctctggccctagtactctatcccctctccctgctttcctcttctacttca ctgctccttaacattgtgttatacattgtctgtctccccaactggaatgtaagtggcacc agggcagggacttgggttgttttgttccttgctgtaagcccagggcccagggccagacct ggaacaattaggtgctaagttatttgctgaatattctatgaaggaatgacaaaggaatgc ataaagaacttcaaagttcaactcctcgaacttcaaacttcaaatccccaactcctcctg cctatgctggacgattagggcagtaacaggagtcaacttg >IGR2147a ttttgttccttgctgtaagcccagggcccagggccagacctggaacaattaggtgctaag ttatttgctgaatattctatgaaggaatgacaaaggaatgcataaagaacttcaaagttc aactcctcgaacttcaaacttcaaatccccaactcctcctgcctatgctggacgattagg gcagtaacaggagtcaacttgtgctgtgctgtcaccttgcctggatccgcatcagccctg cagctcccactttggaggagacttgcccagggacctacagctctgaagcttctctgacag cctctgcagctcttggaacttatctgggctgctgctgtgcagaccatggatgcgtagctg agttcctgcccctgatttcctagagtctcagaaagacagggaagtgacttacccaaagtc ccctttcaccctataaacagttcagcccagggagtgaggctgacacgcaaatgcagctat gtatagactcagagtcatccaaggtcagggctgggtggagccttggtcacatgcaggcca acctgtgtctggagataatgcaagccagtgcaggggttagcgtgtacatggactctggag tctggcagatctaagccccacccaccaacctgtgaccttggagaattatttgaaaagaca ttatttgaaaagcagatgtaaaatggaaataaaagttcct >IGR2148a caaggtcagggctgggtggagccttggtcacatgcaggccaacctgtgtctggagataat gcaagccagtgcaggggttagcgtgtacatggactctggagtctggcagatctaagcccc acccaccaacctgtgaccttggagaattatttgaaaagacattatttgaaaagcagatgt aaaatggaaataaaagttcctatttaaaacagtcagttgtcccccattcagaagcctatt acagttgtccctcagcatcttcgaggaattggttccaggacagctcctcagataccaaaa gccacgatgctcaaattccttataaaaagtgacgtagggctgggtacaatggctcgtgcc tgtaatcccagcactttgggagaccgaggtgggcagctcacttgaggtcaggagttcaag accagcctcgccaacatggtgaaaccccgtctcctctaaaaatacaaaaaataggcgggc ttggtggcatgcacttgtagtcccagccactcgggaggctgaggcatgagaattgcatgg atccgggaggcggaggttgcaataagccaagatcgcaccactgcactccagcctgggtga cagagtgagacttcatctcaaaaacaaaaaacaaacaaacaaaaaatgtgtagcacagtc agccctccgtatccacaggtccacacacagaacctgctgg >IGR2149a gtcccagccactcgggaggctgaggcatgagaattgcatggatccgggaggcggaggttg caataagccaagatcgcaccactgcactccagcctgggtgacagagtgagacttcatctc aaaaacaaaaaacaaacaaacaaaaaatgtgtagcacagtcagccctccgtatccacagg tccacacacagaacctgctggtatggagggccaaccgtgcttcctattcttttttttttt tctttgagacagagtctcactctgtcacccaggctggagtgcagtggcacaatcttggct cactgcaagctccacctcccaggttcacgccattctcctgcctcagcctcctgagtagct gggactacaggcacacgccaccatgcctggctaattttttgtatttttagtagagaaggg gtttcaccatgttagccacgatggtctccatctcctgacctcgtgatccacccgcctcgg cctcccaaagtgctgggattacaggcgtgagccaccgcgcccggccacttcctattcctt atggtatcaaattcaaactccttggcttgatagtcaaactctcaccacgactgaaatctg gttaaccaacctgtccaatacaatctctctgcactcctccaaataatgttcaagttggac ctaagtgctccctagtccttctcacacctgtgtgcctgga >IGR2150a tacaggcgtgagccaccgcgcccggccacttcctattccttatggtatcaaattcaaact ccttggcttgatagtcaaactctcaccacgactgaaatctggttaaccaacctgtccaat acaatctctctgcactcctccaaataatgttcaagttggacctaagtgctccctagtcct tctcacacctgtgtgcctggaaacaccacccaccttcttttctctcatctgaatttacta gagccccagaggcaggtctcatagtcttccctgacttgggtttttttggcactgactact gggcattcatgatgggacctgcccctggggctctagtatttggtgttacagggaggaaca cagttttgattccccaaacagaacaaaggatccttgagggcaactgtctgttgtcatttc atgtctcccccaaccaggcattaaaacacgcatagaaattcctgctgacgggctcttgtg aagttacaagttacaatttggtgaaaatgcccccaagtatttcctctatttcccaaggaa aggaaaagaaagatatagaaattaaattaaagacaaacttaaatcattcccatttctgca tgcttggtctgtgtgggaaaaaaaaatcatttcatctctgtctgcaacgcagacttgaca agttgagaaactccctaaaaacaaagcatacaaaaaaaaa >IGR2151a ggtgaaaatgcccccaagtatttcctctatttcccaaggaaaggaaaagaaagatataga aattaaattaaagacaaacttaaatcattcccatttctgcatgcttggtctgtgtgggaa aaaaaaatcatttcatctctgtctgcaacgcagacttgacaagttgagaaactccctaaa aacaaagcatacaaaaaaaaaatcataccaattagtctcacttaaaggtttcaggaagga aaacacagttaaactgaaaacggttaactggtgtttaaaaaaaagaaaccagcccggaaa tgtttttaggactgcgtctatcgaagtcccttagggactgatttgtccttcaatatattc atagcacctgctttcaccaaaacccagcagcccaacgctagagctttgtgagtgagatgc agagtggaactggacatggagctacacagctctgaatcatgttccccaacagcaagcaac agccacatgaaggattcctggcagtgccctctagccactacagtgggccatgggaagccg tacaaacagcaaatggcatcctgcaaccccagcttctccttctgccgcattcctctctct gtccatgcctctgcttccccattggcccactggccaaatacactcagaaaaaagtccatg cacaagcctccacccaaattaattccacattctttcaaga >IGR2152a ggcagtgccctctagccactacagtgggccatgggaagccgtacaaacagcaaatggcat cctgcaaccccagcttctccttctgccgcattcctctctctgtccatgcctctgcttccc cattggcccactggccaaatacactcagaaaaaagtccatgcacaagcctccacccaaat taattccacattctttcaagagaggccttgaaaggtactgaaattcagggaagctcttca ctagacccctcactggaatgccaagaagtgatgtagtggcccttgacataagggcttatt cccatttatgaaactgaaattattttattctaagcacaaagctaacaaatgtgatcaaaa cagaaaataaacaatcctcattcaagtgctcagaatgcagcacaaataggatcttgggat aaataagatagagctgtgaaattaataggggtgagaagaggggagggtcagcgggagaag tccaccaaggggctgaaaggcctgtgcaggcagacggaaaccctgggttcttaggggcca ggcatgacagtgcagaatagtccaccctgggagtgactggaagaaggactgcagggtccc cgtgaagaacacctcacactcccagcttgccacacacttgttgaactattctgggtggat acctcctacctggatggcaaaggagacaggcccaagatgc .
>IGR215 3 a gcctgtgcaggcagacggaaaccctgggttcttaggggccaggcatgacagtgcagaata gtccaccctgggagtgactggaagaaggactgcagggtccccgtgaagaacacctcacac tcccagcttgccacacacttgttgaactattctgggtggatacctcctacctggatggca aaggagacaggcccaagatgcagaagggaagggaagtcacacttacaatgcagaggatgc gcccttgtccctcatactctctgaaacattgcaggaataattctggtttcactgctattg tttgttgtttttgtaaataaaccgcaaaaatcaacaaatggcctcaaaattgaacacatg tgatttacaccaattcatatatcaaaacacaaataatgcagaacaaattagagaaaaact ccagtcaggctctccactcacccatggctggtggctggcattcaactctccagcagccag ggagtccattttcttgtttctctgctggccatcctcaggacttgcggcggggagtggggg gcccagggtgtgctgccacctgcaggccaaacaaggaaaaaacataagcaacggccacaa tcatccgcctgaagcccctcctatatcctcaggccgctggaagacctggatgcccgtcgt gggacaagagccagaagcactcacccagtgccaacacctg >IGR2154a ctctgctggccatcctcaggacttgcggcggggagtggggggcccagggtgtgctgccac ctgcaggccaaacaaggaaaaaacataagcaacggccacaatcatccgcctgaagcccct cctatatcctcaggccgctggaagacctggatgcccgtcgtgggacaagagccagaagca ctcacccagtgccaacacctgctgggccacaaacagtttctgcttgggatcccaacacag gcagcagagtcagcaaaaactctaagatatcaagaagtcaagcatttcttaacaacagca gcaaactcttacacagggctgtggttaccagacactgctctaaataacttacacttgttt acttatttcatcctcacaacaacgggtaaatattttaggtctctgccaatttgcctgatt actgaattaggttgaatcattaaaatgaataacttgataatacccaatttcaaagagggg tcacatatgaaaactctatgagagattctcagcatcttgcagacattcattccctaaata ttcattgagtgtttgttatggacgagacactgttctaggacctgggaagagaggagcgaa cacacaagacaaagtccctgttctcacgaagcttctgttccagtgcggggaggcaacagt agaaaaggagacaaatgccatgcagaagaaaaagcaggga >IGR2155a gagagattctcagcatcttgcagacattcattccctaaatattcattgagtgtttgttat ggacgagacactgttctaggacctgggaagagaggagcgaacacacaagacaaagtccct gttctcacgaagcttctgttccagtgcggggaggcaacagtagaaaaggagacaaatgcc atgcagaagaaaaagcagggaaaaagagatagagcacaatgacaatgctgttaataccca ttcatttattcacttatttccaaggacttactaaccatgtcatttcttgcccacagctgc atgccaggcactatgccagataaaattgtgggtaagaaatagacatggtctctgcctgta tggagtacttacataagaggaacatctattattagtcaaataatcacctaaataaatgca aagatgttaatctgtgataggtgtgatagcagaattgcatgtagtccttgtgagagcatc tcaaggaggcctgaccttgtctaaggggaggcctgaaatggagtgtggggaggagcaatg tgttagtccattttgcattgctataaaggaatatctgaggctgggtaatttataaagaaa agaggtttaaggcggggtgcagtggctcacacctgtaatcccagtactttgggaggctga ggcaggtggatcatctgaggtcaggagttcgggaccaacc >IGR2156a tctaaggggaggcctgaaatggagtgtggggaggagcaatgtgttagtccattttgcatt gctataaaggaatatctgaggctgggtaatttataaagaaaagaggtttaaggcggggtg cagtggctcacacctgtaatcccagtactttgggaggctgaggcaggtggatcatctgag gtcaggagttcgggaccaacctggccaacatggtgaaaccctgtcgctactaaaaacaca aaaattagctgggtgtggtggtgcacgcctgtaatcccagctacttgggaggctgaggca gaagaattgcttgaactggagaggctgaggttgcagtgagccaagatcgtgccaccgcac tccagcctgggtgacagagcgagaatccgtctcaaaaaaagaaaaagaaaagaaaagagg tttggctcacagttctgtagactgtacaagtgtggcaccagcatctgcttggcttctggt caggcctcaggatgctcacaatcatggtgaaaggtaaagggggagctggcatgtcacatg gcacaagaaggagcaagaaaggggaggaggtgccaagcctcctttaaacaaccagctctc gcctgaacagagtaagaactcactcattacctcggggagggcaccaaaccattcatgagg gatccagccccatgacccaaacacctcccaccaggcccca >IGR2157a aatcatggtgaaaggtaaagggggagctggcatgtcacatggcacaagaaggagcaagaa aggggaggaggtgccaagcctcctttaaacaaccagctctcgcctgaacagagtaagaac tcactcattacctcggggagggcaccaaaccattcatgagggatccagccccatgaccca aacacctcccaccaggccccacctccaatgctggcgatcacatttcaacatgagatttgg aagagacatgcatccaaaccatatcaagcagtgtccctgtcaaaagcacaccctgtgcac aggctggatcatgggtagttggcagggacaggaggcagggtgaagctggagaagcagtgt aggtgacccttgcatgacactcccagccacaagaggagttcgagccttaaccctggagaa ctggagcaccacacaagggtcttaggcagaggattaatgcatttagatgtgtacttttaa aagattatctatgtaggctgagtaatggccctgccaaagatgtctatgtgtgaatccctg gaggttgtgtgtatgttcccctatatggcataagggacattgcaaatgtgatcgagttaa gggtcctgagaaccggagattatccaggtgggcccaacataatcacaagtgtccttataa gagggaggcagggggagatctgacttcagatgaggagcct >IGR2158a gagtaatggccctgccaaagatgtctatgtgtgaatccctggaggttgtgtgtatgttcc cctatatggcataagggacattgcaaatgtgatcgagttaagggtcctgagaaccggaga ttatccaggtgggcccaacataatcacaagtgtccttataagagggaggcagggggagat ctgacttcagatgaggagcctcagaatgatgtggcacgagaaagacttggcttcgaagag gaggaaggggccctgagccagggaatgcagtggcctctagaagctggaaaaagcaacaaa acgattctcctctagagcctccagaaggaacgcagccctgccaaagccttaatttcagga cttctaaaagagtaaatttgtgttgttttaaggcactgattttgtggtaatttgttacag cagcaataggagaataggacatactagctcctgtaaaaaaccagactggacgtaagggcg aggcgaggcagggaccagctagaggtcactgctgtggtccaggcaagaggtgtgagagct tgcaccacagtggtggccgtggggatggagaggagtggtgcagttgaaggaccccagcag gggaagagctgaccagtcaaaggtctcgctgcaatctggcagatgttactggaatgccac aacaggcctctttcaggctcaggccctggctggctcaccc >IGR2159a tagaggtcactgctgtggtccaggcaagaggtgtgagagcttgcaccacagtggtggccg tggggatggagaggagtggtgcagttgaaggaccccagcaggggaagagctgaccagtca aaggtctcgctgcaatctggcagatgttactggaatgccacaacaggcctctttcaggct caggccctggctggctcaccctggctacagcccagcagctttacagaaggaggaagctca caccagggctgtagaccactcccaggcagatgcaccatttactcacttaacctgccaacc ccattcccacaaaaaagttcaagagtctccaggaacaagccctaagaaagaacacgtggg gaatttttactaggcaaaaggtagcaattatttctgccaagcattaagccttgcagcgaa ctttttttttttttccgtgaacagagattttgtaattctggaagagaggtgtccagattt aaatatacacatctccaacacaggtgatacagaaccatgattaaatctaacatctaaaaa cttcatggtcagcagaaaatgcagaaattaaagaaagactaaacaagaaactaggagact cagcgtctactctattcttgcttaataatccagacctacttaaaaaatgggatcctaatt tggtcctgtttaatggagctgtcaagaagaaaaagcaata >IGR2160a acaggtgatacagaaccatgattaaatctaacatctaaaaacttcatggtcagcagaaaa tgcagaaattaaagaaagactaaacaagaaactaggagactcagcgtctactctattctt gcttaataatccagacctacttaaaaaatgggatcctaatttggtcctgtttaatggagc tgtcaagaagaaaaagcaataaaaattattcgagagaattttagaaacattctcccattc tactccaaaaatataaatatgcacactccaaaaccaagtaccttggactgtactgagaga tgacaatgacgtcttaaccgtactatttccccatgatgttgcagcaggccacagggacct aactgaattgtaagaacatgaaaggacccaggaatgcctgcagatgacaaaataccaggt agtcctgtcagtgtaggagcatgttaatttaaaaatagatatatttttctggtgacaaaa gtgacatgtctattactggaaaacacaaacaactcctgtagtccaatgatccagagataa cccatttggaaatattttcttccagtcttttttccccattgatttcggcacaggcgcgcg cacacacacacacacacacacacacacacacacactcatacttcatttttaacaaaatta caatactgtatatacttttataaccagttttatataacag >IGR2161 a aaaacacaaacaactcctgtagtccaatgatccagagataacccatttggaaatattttc ttccagtcttttttccccattgatttcggcacaggcgcgcgcacacacacacacacacac acacacacacacacactcatacttcatttttaacaaaattacaatactgtatatactttt ataaccagttttatataacagtatataatcctccatgtattaaatacagtttttcataat gctagtattccatcatatgaaagtaggaaaatcacttaaccaatccctaattgctgaaca actgagtagtttctaactttatggtaacataagtcattgggaggaacctcctcatctacg ggaatatccctagatataaatctatgtctatagctctgattatttccttagggtcctatt tcctacatccatgcattgccattactattttgctataattaattaccatctgtaatgtac ttaacatttctctttacatcaactcatttctgtccttaaacaaatgtattttaaaagcaa acctgactcggtgtagtggctcacacctgtaatcctagcactttgggaaaacaaggcagg cggattgcctgagctcaagagttcaagaccagcctgggcaacatggcgaaaccccgtctg tactaaaaatacaaaaaatcagccgggtgtggtggtgcgt >IGR2162a caactcatttctgtccttaaacaaatgtattttaaaagcaaacctgactcggtgtagtgg ctcacacctgtaatcctagcactttgggaaaacaaggcaggcggattgcctgagctcaag agttcaagaccagcctgggcaacatggcgaaaccccgtctgtactaaaaatacaaaaaat cagccgggtgtggtggtgcgtgcctgtagtcccagctactcaagaggctgaggcacaaga atcgcttgaacctatgaagcagaagttgcagtgagccaagatcatgccactgcactctag cctggacaacaggacaagactctgtctcaaaaaacaaacaaacaaacaaacaaaccttat ttaagtggaaaaccaacatcatatgccataaatgaaggcaatcataataggttttattgg aataaaaaaacactgtggttaaaatatagtcaaaatactgctacccctttgcccattctt ttatataaaatgggagattagagaggcttagagaggtgttaaaggtatgctagcaccaag ctaaagtttttcaccttccgttgatcagaagactgaaaaggaattgagcatgggaataac tttctcactgtgagtcagtgttagacaatgtggcaaatgtgtcccaactagaattaccct gcgccacctgaaataacctcatatgaaaacatgccttagg >IGR2163 a agagaggcttagagaggtgttaaaggtatgctagcaccaagctaaagtttttcaccttcc gttgatcagaagactgaaaaggaattgagcatgggaataactttctcactgtgagtcagt gttagacaatgtggcaaatgtgtcccaactagaattaccctgcgccacctgaaataacct catatgaaaacatgccttaggacatattcctggaagtagaactgggataaaaggcatgga cactttaagcagcttctgataaccacagcccaaacaccatccaagttagttttaccacag ttttactatgactgtgtccattttacttcacgttcacaaatattaagtactataaacaaa atattaaaatagttaaaacgtttcagctttttgatgtaaaatatccagcagctgaatctt caaaggctattttcatgctcttctagctagtccctgaccctagggcagggctattttatg aacctttaattagtggtaagcttacaacaaactgatactgcacttggtttcaccaagctg aagtaaactctgtaaaagatgaggaagtgactttagcatttgcaaatatttcagaatgcc tttgtgccagcaaaggtcaaacaacgatcagaattgcatggattccaaagtatacttttg ggaaataagagactcagagaagcattactcaagatacaat >IGR2164a gcttacaacaaactgatactgcacttggtttcaccaagctgaagtaaactctgtaaaaga tgaggaagtgactttagcatttgcaaatatttcagaatgcctttgtgccagcaaaggtca aacaacgatcagaattgcatggattccaaagtatacttttgggaaataagagactcagag aagcattactcaagatacaattcactatgaattttcagcaattcaatgaaaagtctaaaa gaaatacatgtttaaactttcctatcctggtataatatgcaattgcacaaataggttaga ttgtagattaatgcaattgttaatatttctaacatagaaaaaggaaattgtattttgaag caagaagaattaataacaattggaattgttcaggttattttaataattcccaggcagata cctatgtgtatatgtgcctgtggggaaaaggtaaggaaaaagagacgtgagaaaacatac ttatgtaattccagcactttgggaggctgaggcgggtggatcactaggtcaagagattga gaccatcctggccaacatggtgaaaccccgtctctgctaaaaatacaaaaattagctggg catggtgggacctgtagtcccagctactcgggaggctgagacaggtgaagtgcttgagcc cgggaggtggaggttgcagagagctgagattgtaccactg >IGR2165 a tgggaggctgaggcgggtggatcactaggtcaagagattgagaccatcctggccaacatg gtgaaaccccgtctctgctaaaaatacaaaaattagctgggcatggtgggacctgtagtc ccagctactcgggaggctgagacaggtgaagtgcttgagcccgggaggtggaggttgcag agagctgagattgtaccactgcactccagcctgggtgacagagcgagactccatctcaaa aacaaaaacaaaaacaaaaaataaaaaaaaagatttattatgtttggaaggaggttatag gttctgattaatttttgccagagacaaaaatacaagtttatctaagcttaagaactaaat gatggcctattgtaagatatagaacttccaactcactgaataaaaagaaggaaagaagaa acaggggacaaatacactttgatgaatccatagagtcacaaggaaaaaaaaaacacacat gataaatacatggcaaaacaagatggcaaaaataagaccacatttatcagtgatcaaaat aaatatgaatgaattaaattccattgttaaaagaccaagactttcaccctaaatgcccat aaatggaaaatggataaattatggtatgtattccattttaatggatgtgtatgtgtgtgt atgtatgtgtatgtgtgtgtatacaccacagaaagaggcc >IGR2166a aagatggcaaaaataagaccacatttatcagtgatcaaaataaatatgaatgaattaaat tccattgttaaaagaccaagactttcaccctaaatgcccataaatggaaaatggataaat tatggtatgtattccattttaatggatgtgtatgtgtgtgtatgtatgtgtatgtgtgtg tatacaccacagaaagaggcccatgagtttcagtttagaaagatgtagaaatatatttgt ataagcataggaaagggtccagaaaaacacaccaatatgatatctgtggttgcctataaa gagcagtttacctatgagtttcagtttagaaagttgtagaaaaatatttgtataagcata ggaaagggtccagaaaaacacaccaatatgatatctgtggttgcctatggaggctgaagt ggactttcctgtctcactttacaaatgtctatactgtttgaatttattacaaaagcatat gactaaagaaacatgaaaaaatggaataataaacataagggcagaatcagcaaaatagag gacatagaggaccaaaaaaaaggtggttaacaaaacttgaagtatttatttgaaagtaga caaacctctagtgagactgatcaagaataactgacagaagattttttaaaaatgagatta cagaaaaaggaagaaatgacaaataaaacagacattttaa >IGR2167a aatggaataataaacataagggcagaatcagcaaaatagaggacatagaggaccaaaaaa aaggtggttaacaaaacttgaagtatttatttgaaagtagacaaacctctagtgagactg atcaagaataactgacagaagattttttaaaaatgagattacagaaaaaggaagaaatga caaataaaacagacattttaaaacttataaaggaataatataaacacatgataatacatt tgaaaatacagatgaaatgaataatttctagacaataaaaattgccaaatttggcacaaa aatgtgaataaccacttaagagactcaaataattttgaaacctcttccccatagagtttc agacccagaagattttacaagtgcctcctactaacttccaaggagcagaaaatctctatc ttaatggagttgctttagaaaatagaaaaaaagagaaaacattgcccaatttgttacttg attttgaaatgttaaatatggactgtacaaataaagaaaaatacaggatagtttcactta taaacatagatgttaaactcctaaataaaatattatctaatcaaatacgaaagtgtatta caaatacatcatgataaagtaattcaccacattagtcgattgtggaagaggttactagtg ctcaccagtctctcgttcttttcctcctgggaacaccacc >IGR2168a ggactgtacaaataaagaaaaatacaggatagtttcacttataaacatagatgttaaact cctaaataaaatattatctaatcaaatacgaaagtgtattacaaatacatcatgataaag taattcaccacattagtcgattgtggaagaggttactagtgctcaccagtctctcgttct tttcctcctgggaacaccaccaggctacatttcccagccaccttacaattaggtgagacc catgagactagtccatgccaatggaatgtgaatggaagtgcatctaattttctggctcat gaaaacagcagcattttctctattttctttttttctttctttgttttttttagacggagt ttagctcttgttgccgaggctggagtgcagtggcgcgatcttggctcactgcaacctccg cctcccgggttcaagcaattctcctacctcagcctcccaagtagctgggattacaggcat gtgccacaatgcctggctaattttgtatttttagtagagacggggtttctccatgtttgt caggctggtctcaaactcccgacctcaggtaatcagcccgcctcggcctcctgaagtgct gggattacaggcgtgagccaccgtgcccggcaagagcagcattttctaaaagcaatcagt actcaacaccatcctgctgaggtagggcagcggcggactc >IGR2169a attttgtatttttagtagagacggggtttctccatgtttgtcaggctggtctcaaactcc cgacctcaggtaatcagcccgcctcggcctcctgaagtgctgggattacaggcgtgagcc accgtgcccggcaagagcagcattttctaaaagcaatcagtactcaacaccatcctgctg aggtagggcagcggcggactccatgttttgaaacttaggaacttagaccatcttttgtca aattcagatggttttctcaaagtaaagatcattcaagttttgtttcagtaatgggccgta tgatcagatctgtgtgattaggctgaattcattattattgagacaaaaattgagttaaag gggattcttggtattggcctgcaaaacctgtcataacttaaatgtaaagtttctgatgat ttagtcactttactctcagctcttagctctttcactcacctgtccttgttctacacaacc tgcctgatgggtaacttgaatacatattttctctcttcaggggatgggaacgccctaagg gcaggggctgtttccacagccctggggtggaacccccttcctgcataccaagaatgagtt ggctatacttgacgaagggcaaagacaaggtggcacgcatctttcatgcttctgctggca gatgcagtggactggaaatttcctggtctgggaaggactc >IGR2170a atacatattttctctcttcaggggatgggaacgccctaagggcaggggctgtttccacag ccctggggtggaacccccttcctgcataccaagaatgagttggctatacttgacgaaggg caaagacaaggtggcacgcatctttcatgcttctgctggcagatgcagtggactggaaat ttcctggtctgggaaggactcggtctgtgagtgcacctatccctgacatctatgctagcc ccgggatgggggccccagcagagtaaggccctgacttcacatggacagggccagggcaag ggggccacatcctggcctagttgctctccatgcccgtgatcaagggagatgagctgccag cttgctcggtcaaggaacacttggaaggcactccaagtgcccccaggtgcaccagatcta ggaaacttaagcaaactacatgaggtatggggtggggcccagtgggaaaaatgagtctga caggtcagagggagtagattatgagctcaggttaggcattctgttcagcattttacgtac accctcccacttttgatttttaccaacacccagggaggtcggtgctctacaaaagggaaa ggcgtgctcaggtggcccgacttgccacggttccagctcgaccccgggctgctagcccct tggcacgcttgtctgaggcctcccaggtcttccagcctgg >IGR2171 a tatgagctcaggttaggcattctgttcagcattttacgtacaccctcccacttttgattt ttaccaacacccagggaggtcggtgctctacaaaagggaaaggcgtgctcaggtggcccg acttgccacggttccagctcgaccccgggctgctagccccttggcacgcttgtctgaggc ctcccaggtcttccagcctggcctggaggctcaaagccacgaaacccaagggtgccgctt ctcaggccctccccgcccccacggcagaacccctgaccctgcccgggtcaaacgcctggc gtcgggcccgccgggtccgcaaggaggagcccgcgaggcggccgcgaaggggctgtgctt acctcgcccggcgcgggttgcggccccagggcccgcgctccaggctggcggccgctgcat tctgcgcccctcgcctgaaacggcagctgcgccagtcctggccacgaccgctttcatttt cctcaacgacatcggcaggaaagcgaaagcgaaaccctccgggaggcgggaccggggccg agcgcgcagtgaacgcggggcgcgcggcgggcgcgggccggcagccagaggcgggggccc cgggctcgggtctgcgcgtggcctggcccggtggcgttcggggtggagctgggccagccg agtgcccgagagctagtccgccacgcacacctgcctcggc >IGR2172a aaagcgaaagcgaaaccctccgggaggcgggaccggggccgagcgcgcagtgaacgcggg gcgcgcggcgggcgcgggccggcagccagaggcgggggccccgggctcgggtctgcgcgt ggcctggcccggtggcgttcggggtggagctgggccagccgagtgcccgagagctagtcc gccacgcacacctgcctcggcgggacccgggcccgggctgggcgggaggctgggcaggcc cgccgtaagtggaaaggcgcccgcggcgcttcggccgaccgggacaggttcctccatctg cccttcattcagcgtttacttgggcctgtggctggcagccggcccgggacctgaccgctg gcggcgcctcgggctctggcctgaggaggcagatggcagcctgagcaactgggaccaagc ctctgaggagtccccgttggaggggacttgaccatgaggtaccaggcatctcatctgggg tcagcggagaacccaaaagtcaatgacgtcggtgaaatgggggtcccttcatccgataag agaaactggaacagcaagcctatggtttggactccctggtctaagcggtgcccatcaata tctaaacatttagagattccaggtttcagtgtctggccgtctcttactgtcagtgatttg gggcaaaatattcaagtagttagacttaattacttcccct >IGR2173 a tcaatgacgtcggtgaaatgggggtcccttcatccgataagagaaactggaacagcaagc ctatggtttggactccctggtctaagcggtgcccatcaatatctaaacatttagagattc caggtttcagtgtctggccgtctcttactgtcagtgatttggggcaaaatattcaagtag ttagacttaattacttcccctgtgggatgggaataataataatcatacctactgccagaa ttttaggaatgaacaatagaaggaagaaaatacttaaaattttctgacagcctctaagtg ggttccttgagggcagcaaccaagtcatttacctggatgcttgatagacattctctaatg gccagtccatcaacttggagctatctccatgataacaggttagttgtcaaagtttggaca atattatctggagtttaaagactgaggaagccctgcaattttttttggaaggtgtctgaa acttagcctgacaattagcccccacaattatgccacggaaccaggtttttgttagagtgg agcatggccacaacgtttgatggacattcctacagcggtgttcagcgctggccactgagg tctgaaaatacttttgcaagcatttctattcacttgcttttagaaaacattggtaagaca ccatactccaaacacagtttgccctgtctgtacgtttgtt >IGR2174a ccccacaattatgccacggaaccaggtttttgttagagtggagcatggccacaacgtttg atggacattcctacagcggtgttcagcgctggccactgaggtctgaaaatacttttgcaa gcatttctattcacttgcttttagaaaacattggtaagacaccatactccaaacacagtt tgccctgtctgtacgtttgttgcaaagcaaacataaaagtttttgccatagagcaaacac agagcagtctgttataactggaacaagaaaccaaaatgagctattaaatctgcccagagt cactttggtttacctgtttgtaatttgggcacattccctgcaagatggaggccctggtct gtgactgatgtaggggcttgtatgtgtccttgcaatagttccctcaagagcaggtgggaa agtggggcaggccaaatgatgaccttagaaaaacaacagcctgtttctctgtccagaaga tgctacttttagtctgtagtatgaaggaaaaagaaaaaacaaaaaaggcaagccttggag cctcttcctccttataggacaattcttgactccaagatagcaaagtagagttaaatctgc ttctgcataaaaactatgtttgggaagatgaagatcaggaaaagacaggaagagatgtaa gcagataagccaaatcctggttaccttttatagacatcac >IGR2175a tatgaaggaaaaagaaaaaacaaaaaaggcaagccttggagcctcttcctccttatagga caattcttgactccaagatagcaaagtagagttaaatctgcttctgcataaaaactatgt ttgggaagatgaagatcaggaaaagacaggaagagatgtaagcagataagccaaatcctg gttaccttttatagacatcacacatgtgaacagagagcatcaggaggtcaaggccggcct gatgtttttcatcttggcaacttcccaaggtccaggtttggtccttgactttgtggggcc aaaaatctcgtctgacttccagtgtaccagagtcgattagcactgttgcataaagtcaga atgacaactgactgatttcattcactatttgctagagaagtgctatgctaaatgcattac atgcattattacctcattatttctccctactatcatgtggtatattataatctatttatt tttcatttgggagaaaaaaagatgaaggaaatcccaaggtcacatggttactatgtatgt tagtggcagggtttgaatcaaggccatctgaccccaaaacctgaagcttatccattcctg ttagaagcaagactgtcgggaacactggactcgaggccacctgatgaacacattctcttc ttgtagccatgcagtttggagccccatagtcagaaggtgg >IGR2176a agatgaaggaaatcccaaggtcacatggttactatgtatgttagtggcagggtttgaatc aaggccatctgaccccaaaacctgaagcttatccattcctgttagaagcaagactgtcgg gaacactggactcgaggccacctgatgaacacattctcttcttgtagccatgcagtttgg agccccatagtcagaaggtggcttagtgagcctaaaatcagaatcggaagagtgaattgt ctgacttaaatgtttgatgatatcaggctcgggcaatgtgggatgtctctttccacaaca caggtcaaaacctataggaagtactgttcactcatccctgctggcctggccagcccttct ccctagatggggcctggtggacaccatctgtttgtgtcaatgaggctctctgtattatgg tacccaggccgcctctcctcagatggacatttttagatagagcaaggcgttactgagtaa cattactcagtaaggtctcgcagcccttatttttctttatggagacattttgtatctttg ctctgattggcttgatttataatttaacttctaaaggacagctttctatcccaccttttg gagacagctctgttttccttactatccttcctgatctaaccctggaacaaaagtttgtgc agtagcaagttctgcaacaagaactttatccaggcctgca >IGR2177a gcagcccttatttttctttatggagacattttgtatctttgctctgattggcttgattta taatttaacttctaaaggacagctttctatcccaccttttggagacagctctgttttcct tactatccttcctgatctaaccctggaacaaaagtttgtgcagtagcaagttctgcaaca agaactttatccaggcctgcactgatagtcagtaaagacacaaaagaagcaaaagtccaa gtccaaggccagtcccaaaagactttactacagaatcgggcaatggagggttggggggcg gggcacagctgatgatcacgcaacccagctgaagaatgatataaatggaatgaaagcatg gtgcaagcagcatctaacttaggagtcactggttaggaaaaaaaaatacctgatgtgtga ttcagataaaaatgaaaaaaataacccttttagatatttcattcaacaaatattctgtgg caactacaaaatgcagccaccctgctaatgctggggattcagtgatgagcaaaaataaat gtggtctctgccctcgggaaacacacttgagtgaggtaataaagcaatcaaataattggt caaatatagaatgccatcctaaatactacaagatgcgtttgacgctataagagggaatgc cagaggcaaaactcctctaatgggccacctgtactctggg >IGR2178a ccctgctaatgctggggattcagtgatgagcaaaaataaatgtggtctctgccctcggga aacacacttgagtgaggtaataaagcaatcaaataattggtcaaatatagaatgccatcc taaatactacaagatgcgtttgacgctataagagggaatgccagaggcaaaactcctcta atgggccacctgtactctggggcttcctgtcagtctggccagcactttctcagaatggct ctgcagtctgaggctcttcctatctactcctccatccttccctcttctctttcacagggg tcagacctgcattacggtgtggggctctctctgcttactcttgcttctgctcctctttat tcttcataggcattttccccaataaactcttccaggtttaattccatcttggtgtctgct ctaggaggacccaagctgacacaatgatgcccttcattgacttggagaaccttggaagag gcccaagttttggagggctccaattctgcacatgttggcttaggtgtcaggtgggcaagg aagctccatatctgctttcccactcagaagataatgcttgtgctttggtactaagctatc aaccatgtcctctgtgggagctagggtctggtcttgtttttaaaatgcttgttccatgga taatcagcaattctcagtttagatctcaatactagaacta >IGR2I79a ccaattctgcacatgttggcttaggtgtcaggtgggcaaggaagctccatatctgctttc ccactcagaagataatgcttgtgctttggtactaagctatcaaccatgtcctctgtggga gctagggtctggtcttgtttttaaaatgcttgttccatggataatcagcaattctcagtt tagatctcaatactagaactatttccctctagaaaagcacaacctaccaatagcaaaaaa catcccttaacttccttgaggaggagttaaaagtcaaaaaatcgaaaggagatgagcaat tgttcctgaacagccaaagggaaataattttgatgtaggggggcccttagttttctggga aaaggaagtctttttttttttttttttttttgagatggagttttgctcttgttccccagg ctggaatgtgatggtgtggtcttggctcactacaatctctgcctcccaggttcaagtgat tcttctacctcagcctcccaagtagctgggattacaggcacccgccaccacacctggcta atttttgtatttttagtagagacagggtttccttatgttggccaagctggtggcgaactc cagacctcaggtgatccacccacctcagcctcccaaagtgctgggattacaggtgtgagt cactgcacccggcctggaagtcatcttttataagtgttcc >IGR2180a aagtagctgggattacaggcacccgccaccacacctggctaatttttgtatttttagtag agacagggtttccttatgttggccaagctggtggcgaactccagacctcaggtgatccac ccacctcagcctcccaaagtgctgggattacaggtgtgagtcactgcacccggcctggaa gtcatcttttataagtgttccttaaggaaagaacttacatgtttggcagcacagatggaa atctgtcattgttggtagaaagaagctagcactccaaaaggcacttttgctctgagctta gcctccctgagcaaggtgcccttggagagctgggtgtcaaaggatgaccctgtcactgag gttcagtcaccagcaacctgttgtgagtgaatcatctgtttgaaggcagagctcttcagg tccaccgctggttcttcccatggaaggaggcttgaacacaaatcatgagtactacatgaa tatttgaacgtggcactcagtcatagtcaagtatagcatttccctcaccaactgcacacc ccagggagcccatatccatctcatggtggtgtggaggctgacagtaggcgagtttacatg ctttgttcccaagctgtcaggaagcccagatactattagtctgcttggtctaaaaagaga aagaagtaggtgtgggcttcatgaaggatgttttgctgag >IGR2181a gtcatagtcaagtatagcatttccctcaccaactgcacaccccagggagcccatatccat ctcatggtggtgtggaggctgacagtaggcgagtttacatgctttgttcccaagctgtca ggaagcccagatactattagtctgcttggtctaaaaagagaaagaagtaggtgtgggctt catgaaggatgttttgctgagggctgtgtctctcattcaaggatgaatgagtaaaagcat ttgttaagttttttttttttaaaactaccaaatgtacagtgagtgtactacttaagcacc ttagggataagcctgtcttttccgccaaaggtagttacaatttccctcatggaaccaagc ataatatgataaggactaattatttgtagagtcaataattacattataatttacacgcat gatctaatttaatctttatagaaacctgatataggtaaggaattttacagttgaggaaac agtctcaggaaagttaagtgacttccccaaagttatagagctagtaagtgaagacatcta cttttggaccatatactttatctactctggatctgggcacttagccaaagccatagtgcc tccaagaaagaggatgtcatggggtaaaccttgaacatgaatagaattgggataatcaga gatgaagcaggacaacgtatggatggaggcaggagtgtca >IGR2182a gacttccccaaagttatagagctagtaagtgaagacatctacttttggaccatatacttt atctactctggatctgggcacttagccaaagccatagtgcctccaagaaagaggatgtca tggggtaaaccttgaacatgaatagaattgggataatcagagatgaagcaggacaacgta tggatggaggcaggagtgtcaaggagaaatagagagctaaaagtgtgtcatatcaggagt tgaaatgcattaaaaatatgtgaagtttggacccttttatcgtaatataatgaccttctt tgtcttgttaaaatctatttgtctgatattaatacagccattcaaactctcttttggtta tttgtatggaagatctttccaaccttttaattttcaacctatttgtgtctttgaatctaa attgaaactgttgtagacatcataatagttgcatcatgattttaaaatctatttggtgaa tctctgccttttaattgaagagttacatttaatataattactgaaaagggcttactcctg ccattttgctatttgttttctatgtcttttatcttttttgctcctcaattccttcattac tgctttcttttgtgttaaatccatattttctaggataattctaaatctgtatctttttaa agtatatattatttatttattttcttaataattgccctag >IGR2183a gagttacatttaatataattactgaaaagggcttactcctgccattttgctatttgtttt ctatgtcttttatcttttttgctcctcaattccttcattactgctttcttttgtgttaaa tccatattttctaggataattctaaatctgtatctttttaaagtatatattatttattta ttttcttaataattgccctagagattacagttcatatattaatttgtaacaacctggttt agattaataccaagttaatttcaataatatgcaaacactttgttcttattcagctctact ccctttatattatatttccacaaattacatctttacacattgtatgcccatcaacctaaa tttttaattattgctttatgcagttgtcttttaaaattatgtaggaaaagagaggttagg aaaaaaattaatactgccctttatatttacttaggtagctacctctccccatgttcatta ttccttcatgcagattcaagtattcaagttactggccagtgtcctttcattttagcctga aagactccctttagcatttttttttttttttgagatggagtctccttgttctgttgtcca ggctggagtgcagtggcacaatctcagctcactgcaacctctgcctcccaagttccagtg attctcgtgcctcagcctcccaagtagctgggattacaga >IGR2184a gtattcaagttactggccagtgtcctttcattttagcctgaaagactccctttagcattt ttttttttttttgagatggagtctccttgttctgttgtccaggctggagtgcagtggcac aatctcagctcactgcaacctctgcctcccaagttccagtgattctcgtgcctcagcctc ccaagtagctgggattacagacatgtgccaccagcctggctaatttttgtatttttagta gaggcagagtttcaccatattgaccaggctggtctcaaactccaaacctcaggtgatctg cccaccttggcctcccaaagtgctgggattacaggcatgagccactgtgcctggcccttt agcatatttttttaagtactttaagttctagggtacatgtatacaatgtgcaggtttgtt acataggtatacatgtgccatgttggtttgctgcacccatcaacttgtcatttacattag atatttctcctaatgctacccctccctcagcctcccaccccctgacaggccctggtgtgt aatgttccctgccctgtatccatgtgttctcattgttcaattcccacctatgagtgagac catgtggtgtttggttttctgtcgttgtgagagtttgctgagaatgatggtttccagcct atccatgtccctgcaaaggacatgaactcatcctttttta >IGR2185a ccctccctcagcctcccaccccctgacaggccctggtgtgtaatgttccctgccctgtat ccatgtgttctcattgttcaattcccacctatgagtgagaccatgtggtgtttggttttc tgtcgttgtgagagtttgctgagaatgatggtttccagcctatccatgtccctgcaaagg acatgaactcatccttttttatggctgcatagtattccatggtgtatatgtgccacattt tcttaatccagtctatcattgatgaacaactgggttgcttccaagtctttgctattgtga atagtgccacaataaacatacgtgtgcatgtgtctttatagtagcatgatttataatcct ttgggtatatacccagtaatgggatggctgggtcaaatggtatttctagttctagatcct tgaggaatcgccacactgtcttccacaatggttgaactaatttacactcccaccaacagt gtaaaagctttcctatttctccacatcctctgcagcatctgttgtttcctgactttttaa taatcgccattctaactggcgtgagatatctcattgtaattttgaattgcatttctctga tgagcagtgatgatgagcattttttcatgtgtctattggttgcataaatgtcttcttttg agaagtgtctgttcatatacttttcccctgtttgtttttt >IGR2186a tccacatcctctgcagcatctgttgtttcctgactttttaataatcgccattctaactgg cgtgagatatctcattgtaattttgaattgcatttctctgatgagcagtgatgatgagca ttttttcatgtgtctattggttgcataaatgtcttcttttgagaagtgtctgttcatata cttttcccctgtttgtttttttcttgtaaaattgtttaagttctttgtagattctagata ttagccctttttcagatgggtagattgcaaaaattttctcctgttctgtaggttgcctgt tcactctgatggtagtttcttttgctgtgcagaagctctttagtttaattagatcccatt tgtcatttttggcttttgttgccattgcttttggtgttttattcatgaagtccttgccca tgcctgtgtcctgaatggtattgtctaggttttcttctaggtttttatggtgtttttttg tttgtttgtttttgttttttgagacagtctcactctgtcgcccaggctagagtgcagtgg tgcaatctcggctcactgcaacctccgacttctgggttcacaccattctcctgcctcagc ctcccgagtagctgggactacaggcacccaccactacgcctggctaattttttatatttt tagtagagatggggtttcaccatcttagccaggatggtct >IGR2187a tgagacagtctcactctgtcgcccaggctagagtgcagtggtgcaatctcggctcactgc aacctccgacttctgggttcacaccattctcctgcctcagcctcccgagtagctgggact acaggcacccaccactacgcctggctaattttttatatttttagtagagatggggtttca ccatcttagccaggatggtctcgatctcctgacctcatgatccgccctcctcagcctccc aacgtgctgggattacaggcgtgagccactgcgcctggcaggttttcatcgttttagatc ttaacgtctaagtctttaatccatcttgaattaatttttgtataaggtgtaaggaaggga tccaatttcagctttctacatatggctagccagttttcccagcaccatttattaaatagg gattcctttccccatttcttgttatttcttgtttttgtcaggtctgtcaaagatcaaatg gttgtagatgtgtggtgttatttctgaggcctctgttctgttgcattggtctatatatct gttttcgtaccagtgccatgctgttttggttactgtagccttgtaatatagcttgaattc agacagcgtgatgcctccagctttgttctttttgcttaggattgtcttggctatgcgggc tcttttttggttccatatgaactttaaagtagttttttcc >IGR2188a atttctgaggcctctgttctgttgcattggtctatatatctgttttcgtaccagtgccat gctgttttggttactgtagccttgtaatatagcttgaattcagacagcgtgatgcctcca gctttgttctttttgcttaggattgtcttggctatgcgggctcttttttggttccatatg aactttaaagtagttttttccaattctgtgaagaaagtcattggtagcttgatggggatg gcattgaatctgtacattaccttgggcagtatggccattttcacgatattgagtcttcct atccatgaacatggaatgttcttccatttgtttgtgtcctcttttatttcactgagcagt ggtttgtagttctccttgaagaggtccttcacatcccttgtaagtcggattcctaggtat tttgctctctttgtagcaattgtgaatgggagttcactcatgatttggctgtttatctgt tattggggtataggaatgcttgtgaattttgcacattgattttctaacctgagactttgc tgaagttgtttatcaacttaaggagattttgggctgagatgatggggttttctaaatata caatcatgtcatctgcagacagggacaatttgacttcctcttttcctaattgaataccct ttatttctttcccttgcctgattgctctgcccagaacttc >IGR2189a ttgtgaattttgcacattgattttctaacctgagactttgctgaagttgtttatcaactt aaggagattttgggctgagatgatggggttttctaaatatacaatcatgtcatctgcaga cagggacaatttgacttcctcttttcctaattgaataccctttatttctttcccttgcct gattgctctgcccagaacttccaacaccatgttgaataggagtggtgagagagggcatcc ttgtcttgtgctggttttcaaagggaatgcttccagtttttgcccattcattatgatatt ggctgtgggtttgtcataaatagctcttattattttgagatacattccatcaatacctag tttattgagagtttttagcatgaagggctgttgaattttgtcaaaggccttttctgcatc tattgagataatcatgtgttttttgtcattggttctgtttatatgatgcattacgtttat cgatttgtgtatgttgaaccagccttgcatcccagggatgaagccaacttgatcatggtg gataagctttttgatgtgctgctggattcagtttgccagtattttattgaggatttttgc atcgatgttcatcagggatattgatataaaattctctttttttgttgtgtctctgccagg ctttggtatcaggatgatgctggcctcataaaatgagtta >IGR2190a cagccttgcatcccagggatgaagccaacttgatcatggtggataagctttttgatgtgc tgctggattcagtttgccagtattttattgaggatttttgcatcgatgttcatcagggat attgatataaaattctctttttttgttgtgtctctgccaggctttggtatcaggatgatg ctggcctcataaaatgagttagggaggattccctctttttctattgattggcatagtttc agaagaaatggtagcagctcctctttgtacctctggtagaatttggctgtgaatctgtct ggtcctggcctttttttggttgataggctattaattattgcctcaatttcagagcctgtt attagtgtattcagagattcaactttttcctggtttagtctagggaaggtgtacgtgtcc aggaatttatccatttcttctaaattttctagtttatttccgtagaggtgtttaaagtat tctctgatggtagtttgtatttctgtgggattggtggtgatatcccctttatcatttttt attgtgtctatttgattattctctctttttttctttattagtcttgctggcagtctatca attttgttgatcatttcaaaaaactagctcctggattcattgattttttttgaagggttt tttatgtctctatctccttcagttctgctctgatcttagt >IGR2191 a tttctgtgggattggtggtgatatcccctttatcattttttattgtgtctatttgattat tctctctttttttctttattagtcttgctggcagtctatcaattttgttgatcatttcaa aaaactagctcctggattcattgattttttttgaagggttttttatgtctctatctcctt cagttctgctctgatcttagttatttcttgccttctgctagcttttgaatttgtttgctc ttgcttctctagttcttttaattgtgatgttagggtgttgattttagatgtttcctgctt tctcttgtgggcatttagtgcataaatttccctctacacactgttttaaatgtgtcccag ggatgctggtgcgttgtatctttgttctcattgttttcaaagaacatctttatttctccc ttcatttcgttattcatccagtagtcatttaggagcaggttgttcagtttccatgtagtt gttcagttttgagtgagttccttaatcctgagttctaatttgattgcactgtggtctgag agacagtttgttgtgatttctgtacttttacatttgctgaggagtgctttgcttccaatt acgtgttcaattttagaataagtgtgatgtggtgctgagcagaatgtatattctgttgat ttggggtggagagttctgtagatgtctattaggtccactt >IGR2192a ccttaatcctgagttctaatttgattgcactgtggtctgagagacagtttgttgtgattt ctgtacttttacatttgctgaggagtgctttgcttccaattacgtgttcaattttagaat aagtgtgatgtggtgctgagcagaatgtatattctgttgatttggggtggagagttctgt agatgtctattaggtccacttggtgcagagctgagttctagtcctggatatccttgttga ttttctgtctcattgatctgtctaatattgacagtggggtattaaagtcttccattatta ttgtgtgggagtctaagtctctttgtaggtctctaaggacttgttttatgaatctgggtg ctcctatattggctgcatatatatttaggatagttagctcttcttgttgaattgatccct ttaccattatgtaatggccttctttgtttcttttgatctttgttggtttaaagtctgttt ttatcagaaactaggattgcaacccctgcttttgttttccatttgcttggtagatcttcc tccatcccttcattttgagacaatatatatgtctttgctcatgagataggtcttctgaat acagcacactgatgggtcttgactctttatccaatttgccagtctgtgttttgtaattgg ggcatttagtccatttacatttaaggttaatattgttatg >IGR2193 a caacccctgcttttgttttccatttgcttggtagatcttcctccatcccttcattttgag acaatatatatgtctttgctcatgagataggtcttctgaatacagcacactgatgggtct tgactctttatccaatttgccagtctgtgttttgtaattggggcatttagtccatttaca tttaaggttaatattgttatgtgtgaatttgatcctgtcattatgatgttagctggttgt tttgctcgttagttgatgcagtttcttcctagcattgatggtctttacaatttggcgtgt ttttgcagtggttggtacaagttgttcctttccacgtttagtgcttccttcaggagctct ttaaggcaggcctggtggtgacaaaatctctcagcatttgcttgtctggaaaggatttta tttctccttcacttatgaagcttagtttggctggatatgaaattctgggttgaaaattct tttctttaagaatattgaatattgaatagtggcccccactctcttctggcttatagggtt tctgcagagagatccactgttagtctgatgggcttccctttgtgggtaacccaacctttc tctctggctgcccttaacattttttccttcatttcaaccttggtgaatctgacaattatg tgtcttggggttgctcttcttgaagagtatctttatggtg >IGR2194a tattgaatagtggcccccactctcttctggcttatagggtttctgcagagagatccactg ttagtctgatgggcttccctttgtgggtaacccaacctttctctctggctgcccttaaca ttttttccttcatttcaaccttggtgaatctgacaattatgtgtcttggggttgctcttc ttgaagagtatctttatggtgttctctgtatttcctgaacttgaatgttggcctgccttg ctaggttggggaagttctcctggttaatatcttgaagagtgttttccaacttggttccat tctccctgtcactttcaggtacaccaatcaaacctaggtctggtcttttcacatagtccc atatttcttggaggctttgttcgttccttttcattcttttttctctaatcttgtcttcac gctttatttctgatatcctttctcccgctagattgattcagctatggatacttgtgtatg cttcacaaagttcttgtgtgtgtttttcagctctatcaggtcgtttatgttcttctctaa actggttattctagttagtaattcctctaaccttttttcaaggttcttagcttccttgca ctgggttagaacatgctcctttagctcagggggtttgttattacccaccttctgaaggct gtcatttcgtcaaactcattctccgtctagttttgttccc >IGR2195 a gtgtttttcagctctatcaggtcgtttatgttcttctctaaactggttattctagttagt aattcctctaaccttttttcaaggttcttagcttccttgcactgggttagaacatgctcc tttagctcagggggtttgttattacccaccttctgaaggctgtcatttcgtcaaactcat tctccgtctagttttgttcccttgttggcgaggagttgtggtcctttggaggagaagagg cgttctggtttttggaattttcagcctttttgcactggtttttcctcatcttagtgcatt tatctatctttggtctttgatgttggtgaccttcggatggggtttttgtgtggacgtccg ttttcttgatgttgatgttgatgctgttcctgtttgctagttttccttctaatagtcaga cccctctgctgcaggactgctagagtttgctggagatccactccagaccctgtttgcctg ggtatcaccagcagaggctgcagaacagcaaaaatttctgcctgttcctacctctggaag cttcgtcccagaggggcaccccccagatgccagccagagctctcctgtatgaggtgtctg tcgacccctgttgggaggtgtctcccagttcggaggctcgggggtcagggacccacttga ggaggcagtctgtcccttagcagagctcaagtgctgtgct .
>IGR2196a gcagaacagcaaaaatttctgcctgttcctacctctggaagcttcgtcccagaggggcac cccccagatgccagccagagctctcctgtatgaggtgtctgtcgacccctgttgggaggt gtctcccagttcggaggctcgggggtcagggacccacttgaggaggcagtctgtccctta gcagagctcaagtgctgtgctgggagatccgctgctctcttcagcgccggcaggcacaac atttaagtctgctgaagctgcacccactgctgccccttcccccaggtgctctgtcccaag gagatgggaattttatctataagcccctgactagggctgctgcctttctttcagagatgc cctgcgcagagaggaggaatctagagaggcagtctggctacagcggctttgccagactgc agtccctgggggctttgtttacactgtgaggggaaaactgcctactcaagcctcagtaat ggtggacgcccctcccaccaccaagctcaagagtcccaggttgacttcagacagctgtgc tggcagcaagaatttcaggccagtggatcttagcttgctgggctccatgggggtgggatc cgctgagcaagaccacctggctccctggcttcagccccctttccgggggagtgaatggtt ctgtctcactggtgttccaggcatcactggggtatgaaaa >IGR2197a accaagctcaagagtcccaggttgacttcagacagctgtgctggcagcaagaatttcagg ccagtggatcttagcttgctgggctccatgggggtgggatccgctgagcaagaccacctg gctccctggcttcagccccctttccgggggagtgaatggttctgtctcactggtgttcca ggcatcactggggtatgaaaaaaaactcctgcagctagcttggtgtctacccgaatggcc gccctgttttgtgcttgaaacccagggtctggagatgtaggcacccaagggaatctcctg gtctgcgggttgcgaagactgtggcaaaagcatagtatctgggccagagtgcactgtttc tcatggcacagtccctcatggcttcccttggctaggggagggagttccctgtccccttgc acttcctgggtgaggcgatgccccaccctgctttggcttgccctccgtgggctgcaccca ctgtctaactagtcccaacgagatgagccgggtacctcagttggatatgcagaaatcacc caccttctgcgttgatctcgctaggagctccagaccagagctgttcctggggctttaacg tttttagtgctcatttgtttggcatggggtggggggcaattctatgaggacatttagaat tttcagaactattttgctcataatcaggggttgcatgagc >IGR2198a gagatgagccgggtacctcagttggatatgcagaaatcacccaccttctgcgttgatctc gctaggagctccagaccagagctgttcctggggctttaacgtttttagtgctcatttgtt tggcatggggtggggggcaattctatgaggacatttagaattttcagaactattttgctc ataatcaggggttgcatgagcattaagtttcaaatctcttcagtagacgaaccatgcaaa ataccaatatcactgtgtattagtatttagcagtcttatccttgatgtggagtgtatcct cacacttcctctatgagaagtcttttgtgagacttattcccaggtaaagagccagtcagg ggcctggctgctgccctctggctggcgcaacagacagatgatgtcccagtgtctctggcg gcttcttacagaactctgtccctgaggttatgtcccttcttcatgaggtgacaccttcag gggtgggtctgcctgagagctccaaaacatgatttctgctgagaaacctgtgtctgtcat ' cagtgcatcctctgttaatctcatgagattttattttccaaagtgcttttaaagcaatgg catagaacataaggtgttgccagtgcattgcatcaagcctctatcagcctaaaagccctt taggaaaagaattaaaagacaaacccccagaagaaagttc >IGR2199a ctccaaaacatgatttctgctgagaaacctgtgtctgtcatcagtgcatcctctgttaat ctcatgagattttattttccaaagtgcttttaaagcaatggcatagaacataaggtgttg ccagtgcattgcatcaagcctctatcagcctaaaagccctttaggaaaagaattaaaaga caaacccccagaagaaagttctattgtgctatttactacctggcagggaatagggtcttg tgcccacctcattgaccgtcacttagaccaggtattaagcagaataattctctttgacaa acaacagccttatggaatccatgagaatgttcagggaaccctgacagagataagaattag tttccaagaataggaaaagatggtatggcaaatctttgcctttactttgatctgtggcag gaaactggtttttaagaaaatctgggttgttcctccacctccttttctttgtcttttata tttctgtgggtatgctggtttctagttatacacattaactgaacacctcatcactcacca actctgcccctgtggctacagtttgtgtatgcctctctcctggagcagaggagatccttg gtctgataacacactcagtcttcccaaagtcatggctctaagggaaacaagccacacacg aatccaacaggcttcgacagaggacttggaattccacatg >IGR2200a ttctagttatacacattaactgaacacctcatcactcaccaactctgcccctgtggctac agtttgtgtatgcctctctcctggagcagaggagatccttggtctgataacacactcagt cttcccaaagtcatggctctaagggaaacaagccacacacgaatccaacaggcttcgaca gaggacttggaattccacatgcttggctcaaccctggaagtgacttgggctcttgcctca ccacatgaagagctctaagcattcaggtaattatggtttttgccctcagaaggccacaaa tgactggaatcagtggcatggagaataagagagaaaatgcagaaactattcactcctgct acaggacaatgggtagacagaactgcaattcagattctagagcccctgggaagacagtta atcagtagtccagcacagaaccatgtttgaggagagtggagaagccaacagtgttccaga agacgtgctgccttccttctcccccaagtttgatgctgcttgttttgttatgcaacatgc ccttgagtttctatccaacactggagctttttacccaggtccatccacaccttctagccc aaaatgccctgtgcaaattgtatatagattaagacacctcttgtgcaccacactcaaccc ccaatcctctcagcccaccacttactccagccactgttgc >IGR2201 a tcccccaagtttgatgctgcttgttttgttatgcaacatgcccttgagtttctatccaac actggagctttttacccaggtccatccacaccttctagcccaaaatgccctgtgcaaatt gtatatagattaagacacctcttgtgcaccacactcaacccccaatcctctcagcccacc acttactccagccactgttgcagtgaccagttctgatgggctctggcaacccctacttca gccctgcaatgtattctctcttgctttctacccacgggacagaacttatttgggactcat gcatgtgcagcctggaaacatgtggagctgacacctgtgggctgcctttacaaatggatg ccaacagagaaatgcttcccccttttactcaaggtacagatggtgttgagatgcatttca taagcttcttctgaagtccttgctggatggagcatccctgcctttggtgctagtcaacct gaaaatgcatctttgtattcagcctccctccttccctgttctcctcctgtcctttattgc tgctccctggaatcttgtccccaaagcataaactgcttaactgcacagaagcacttgtct cagtctctactttcaagggaacccaagatacatttgtgcaagaaggctggctcagcccat agtcaattaataaagtgaagaattctagtgcacaagaatc >IGR2202a cagcctccctccttccctgttctcctcctgtcctttattgctgctccctggaatcttgtc cccaaagcataaactgcttaactgcacagaagcacttgtctcagtctctactttcaaggg aacccaagatacatttgtgcaagaaggctggctcagcccatagtcaattaataaagtgaa gaattctagtgcacaagaatcaaatcttagtcttagagattaatcccaaccattgctaga attagcccaagctgatacagagaaaaggcagatgacagtgtggcacaggctcactaaatt ctagaaataaagattctaggcagttgctgatatttaaaaaatcattttacttattaaaac tttctcatttcccaaggcacttcagtagctttcacaaaaacatgtttgttcttttttaac caggtgaggcatatgctttaggagtaccatggtaacataatcagcaaagagaagacaatt acactgaacacaaaatatcacccaataaagttacaggactaaagtgagctactctgaaag actatgaacacaatttaaatttcttttttgtaatatcctcccatgactaagtatcaagaa aggaacacacacaatgacactgtttttggcacttagagaagtgctagaggctagggctgg taaggccttgcaccagtggcagctgcagacaattgccaga >IGR2203a acccaataaagttacaggactaaagtgagctactctgaaagactatgaacacaatttaaa tttcttttttgtaatatcctcccatgactaagtatcaagaaaggaacacacacaatgaca ctgtttttggcacttagagaagtgctagaggctagggctggtaaggccttgcaccagtgg cagctgcagacaattgccagagtgattctgtgtttaaaaaaaaaaaaaaaaagacacaaa ccaggaggctaaggaaccagcctttcccaagtgcattctgaagggcaaataacaaggaga aaaggatacaacaacaaacaaataaacagtaaaacaaaacccacattacagctttgagag aaaagacaacgttgctcatctctctcacctgataaatttcctttaaaccatacataagac gctatagtagcaaggaggtttccacagcagtggaaaacaagaatagtagattcaatggag catttattatgagcctggacaagcccagtgctttgatcagatgtaaacaagtctactcag tcgtcatgctgagtggtcttaagagctcacacatcagtgcactttgctggtgatctgcat ctgctcattctgctccatcttcattacctttcactttccctagctctgcgctctcctgcc ctggggaagcaatgatccagttaatgtcctctgtaactga >IGR2204a caagcccagtgctttgatcagatgtaaacaagtctactcagtcgtcatgctgagtggtct taagagctcacacatcagtgcactttgctggtgatctgcatctgctcattctgctccatc ttcattacctttcactttccctagctctgcgctctcctgccctggggaagcaatgatcca gttaatgtcctctgtaactgagaaaaggtaagaatcaaactccttgtgcaattacttcct tttcctctaaagttcaccactagaggggagtggggaaaggggtgggggacttagacctct agccttattaggggccttttcaagtagtctaaaattaaaatgtacatttagcatatgctt ctcacattcctccagatctcactggttctagtgaaaaattaactgctttggaggtgctga gtccatcattgtaatagttaggacttagatgaagttgtctgtaggtagccccagtgtccc tagaggaaggtggtgctctagggccatatgtagcctctgagtgtgggtgcccatccagga gcaagtcagacacaggtcaagaggacaaacagcaaaggcctttgtcactgaaggactcgg agtctgcacaagctggccatttctggcaagacagtctttcctcttcagtttctcccttac tggaagcgatgttagaaggctgtgcttttaaggattgtgg >IGR2205a agggccatatgtagcctctgagtgtgggtgcccatccaggagcaagtcagacacaggtca agaggacaaacagcaaaggcctttgtcactgaaggactcggagtctgcacaagctggcca tttctggcaagacagtctttcctcttcagtttctcccttactggaagcgatgttagaagg ctgtgcttttaaggattgtgggcctttcttgaccatcttttaacatccttgtgtgacttg gagtttttctgtgtttcattctataaaaacaagcaaaaatatgtcagtaacacattttaa aaagatgcctcccagtctccaaacaaacaagaactgaggatatcttccctgggaagagaa tcctgcagcagattctgaaaggtttcttctagcctctgagttatccagtgcggctactgc catggagatgtgtatagtgacatgtccacacaggaacagaccagagaggatgggctataa gtaagcaccttgccatttacaaccctttaatggctaaactagtccatggtgtctgtgaga gggagtttgcgagtagctctattgtgaggggctcctgagacctggccagacccagaccca gtgcatcaacactgacagaggaggtcttcttaccctttgactcttagcatctggtcaatg gtgtctgggagtggggtaccgaagctctctgggagaaaca >IGR2206a caaccctttaatggctaaactagtccatggtgtctgtgagagggagtttgcgagtagctc tattgtgaggggctcctgagacctggccagacccagacccagtgcatcaacactgacaga ggaggtcttcttaccctttgactcttagcatctggtcaatggtgtctgggagtggggtac cgaagctctctgggagaaacaaggtgaggatggctgtcaggatggtcagacttcccatga gaatgtagggcaggaagcggtcgtaggcacctatggcaaagcagacggagcctcaggccc agggctgcagttagacttggtctctcatctacccctttatgctcccaggactctggaagg ggatcactttccttcttggtctcacatctctcacagtctgagcagtcagattagaatctg gcatctagacaggtttcagaacccagagctggcacaggcatgcccagagcccagcagtgt tccaccatgcaggggaggagtacaaaggggcggttgcaggagaagagctgggccatgctg attattcctatttctgggccatgctgattattcttatttaccaaggttgggtttccaagg aacctgaggtacttgtccagggatggaaataactcttccacctctgcagatgtgtcccag cccatgtgatctgccttcagattaggcagggtgcttttgc >IGR2207a gtacaaaggggcggttgcaggagaagagctgggccatgctgattattcctatttctgggc catgctgattattcttatttaccaaggttgggtttccaaggaacctgaggtacttgtcca gggatggaaataactcttccacctctgcagatgtgtcccagcccatgtgatctgccttca gattaggcagggtgcttttgcttgctttgagatctacatagcatgttcacaaagcactct gagtactctcaggtgggtgccaccctccctaaagaggtactggctagggatgtgcaggga aaccacaggtgctatgaagacataattctgagaagagaaaactggagacctgctacataa aatggcatggggtggatcttcacacaagataaaatcactctatagtgctctaggttataa taattttacgttcatcagacctcttgcatggacatctttcccctcatgttccttttaaac tctgattccaagaaatttctccaactaagcacactggctccctaaaccactctgtaggtt cttaggataaaggaattgtagtctctgatggaaggcctgggatggctaaaacagaaacaa accctctaatattctcatcaatttctaggtaatctataggttgttttccatttgaaagtg agggccagtgcactgggacaagaacccttcccggccaaag >IGR2208a tccaactaagcacactggctccctaaaccactctgtaggttcttaggataaaggaattgt agtctctgatggaaggcctgggatggctaaaacagaaacaaaccctctaatattctcatc aatttctaggtaatctataggttgttttccatttgaaagtgagggccagtgcactgggac aagaacccttcccggccaaagatccagtactggatggagcccatgtactgtatgaacttg ttttcctgttaacacgcaacctccagctcacattcaagccagttagtacttccatcccgt tgctctagtgtgcccttggctcatgggacttaccaaggtaaacgaagtagggagacagga tgctgcccaggcgggatgctgtggagctgactcccacacccatgtttctcaccactgtgg gatacagctcggctgtgtacacgtagaccatggaaaaggcagccgtgactccaaacttgc ccaccatcaccaggactgtagccaaataatacaagtctggagaagcaaaggaaagagggt aggagtaggtaccaacccatggcatgcagctattgagagcaaaacaaacatactttcttc ccaaattttttggggagtcagtttctatcacttcctattgtgggggaaggggctatagcc aagatttccctccaaattgattgctgaaaggaggctggga >IGR2209a agccaaataatacaagtctggagaagcaaaggaaagagggtaggagtaggtaccaaccca tggcatgcagctattgagagcaaaacaaacatactttcttcccaaattttttggggagtc agtttctatcacttcctattgtgggggaaggggctatagccaagatttccctccaaattg attgctgaaaggaggctgggacctgcagctataaggacatgcactttcctcaacctggag accaccagagtaagctccttaatagtccaatcaacctgcttcccagtctataagtcatta aagacatgtctgtcagggattaactgtcaccccagaacctcacactgcaggcactatgga attaactcatgatgtttagatgaatggagaattcagttctaactcatttcatgctttcct cccactcagacctcaaaaaaatcataggccatcagaatctcgagttgatcttctaatctc tctgtgctgtgctgatgggagagctatgtgtgacctgaaggtcactctgagctcagctgt gagcctctacatcagttctgggctcctcctgccacatcccatggggagctgttcccgtgc agtgttctcagcctgatgggcccaaaagtgaccatcagaggctcccaaatctacaggtac actgaagtctctgggcacagtgatggagagggagagatga >IGR221Oa agagctatgtgtgacctgaaggtcactctgagctcagctgtgagcctctacatcagttct gggctcctcctgccacatcccatggggagctgttcccgtgcagtgttctcagcctgatgg gcccaaaagtgaccatcagaggctcccaaatctacaggtacactgaagtctctgggcaca gtgatggagagggagagatgagggcccatgaactgttctataaattattggaaatggcta cctcccacccatctgtgggatactaagatagtttcagaaataaaatcctgctaagggtct gtgaggccctctcagtggtctggcccctccccttctccctcctcctcaaacatgccaggc tcatcccctgctcagggtcgctgcctttgccatttcttcttcctaaaatgttctcctaga ctttttcagggctttctgtcactttatgtacatttctactgaactgccccctgttcaggg acactatctgtgactatgtaaactaactcggcattgtccttcatttgtattcctagaagg taacacagtctgaactatattaagcattttatttacttgtttgttgtctgtcttctcatc tagggtgtacgttccatgagggcctggggttctgcctggcttgttttcttgtgtatcgtt atcaccgagcacagtgcccagcccatggtaggcatgccat >IGR2211a aaactaactcggcattgtccttcatttgtattcctagaaggtaacacagtctgaactata ttaagcattttatttacttgtttgttgtctgtcttctcatctagggtgtacgttccatga gggcctggggttctgcctggcttgttttcttgtgtatcgttatcaccgagcacagtgccc agcccatggtaggcatgccatagctatttgttgaataaataaagaagacagggccaggaa aaaaaggaatgggatagctatttcttccctcttcttctgcagtggaaaacagtatgagca cattaacttgggtacagagtaaaattaaccaacagccccaatggctgctttttcccactc cctcaaagcccaggccataagtgttctagtctcagaagacactttctattgatttttagg ccaagaatgtatataagcaagggagctgtgatgggcttgattttattctctttattaatt gagacagcctggtagacagtaagagactcagtgaagaccccaaaccatagatgcacatgg tccctacctgggggtaccagctgcatgaagagaaggacactgccacccaggaagagggca gtggccatggaatagcgccggggcaaatattgcagcagcagccaggccaacacatatgct gggacttcaaccatcgctgaaaggaagcagttcacaaaga >IGR2212a taagagactcagtgaagaccccaaaccatagatgcacatggtccctacctgggggtacca gctgcatgaagagaaggacactgccacccaggaagagggcagtggccatggaatagcgcc ggggcaaatattgcagcagcagccaggccaacacatatgctgggacttcaaccatcgctg aaaggaagcagttcacaaagatgtccccatgcaagttaggagtatcaagcgaaagcccaa aatagcccactgatatggtcatcctgaaacagagtgcagaagaaagctggaaaagcagta tccacatctttcccaacctgtacaacttttacaatgcaattatttcagtaaattccaaac catctttaagcagagactagtaaggcagcagtaactgtaaccctgcgtcttacttcatag atcaaaagataattttccccagcccaagtggtacagtgtaaaccctgcgccagtgcgctc tcagagccttccatatagacagtgtcccagcaaaaaagcttgtataattcagatagattt acttcattgaaaagaaaaattccaacctgcctttcagctttaaaaatcctaagctgaacc tcctcaaatccagcaactgcagaaggagctagagaatgagtcaggaggcagacatcaa.gt gaggtgtgataggatttgggggataagataacaaaaggaa >IGR2213a cagtgtcccagcaaaaaagcttgtataattcagatagatttacttcattgaaaagaaaaa ttccaacctgcctttcagctttaaaaatcctaagctgaacctcctcaaatccagcaactg cagaaggagctagagaatgagtcaggaggcagacatcaagtgaggtgtgataggatttgg gggataagataacaaaaggaacaacattaggtcaaacacttggagagagaccctcacaca ctacctgtggtgaccagtcaggaagaggctggtcagagacagctgacaccagccccgcgg tacttgtggagcagagaggtggctcccaatggaggggccacactgcctctcatcaggatg ccctgcagtacccctgacctgggcatccccagtaggcattctctctgttgatgacccaca ctctttgacaaaccagacctttatggattagactgttttgactcatctgcaggtggaaca cacagctggtacaataaaaagagtatgtgcatgagtccccaggaaatccagagcagggag gagagcctgggtgaacacaaaagtgggtgactcatcacaggcttgcatgtctgtggtgca ggctacatgctgctcctgtcttgaggccaactcagggaatggtgaactgcctggagggat cctgggccattccttggaagcgggtgactcatagcactcc >IGR2214a agagtatgtgcatgagtccccaggaaatccagagcagggaggagagcctgggtgaacaca aaagtgggtgactcatcacaggcttgcatgtctgtggtgcaggctacatgctgctcctgt cttgaggccaactcagggaatggtgaactgcctggagggatcctgggccattccttggaa gcgggtgactcatagcactccctcagtaggcacagtggctgactgcctcaaagctggatg agactagtaataaggactctgagatgaagtccgccctcctcgcccatcttctcaccgcta acccaccaggctccagaagtcgcctagaatcccagggttcggccgctgagcaaaagctag cgatgtgcacttggacatgtttcctctccctggtaattcacaaatccctttctgacatac tttgcctcattagtgggaacctggtaaggacatctaggctatagccctgactccaggacc gtttatggacatcccaggaggagcacatcccacttccacatttccagaaagtaactggca gcctctgcagcctacaggacatggtgtcttcactcagatccttcttaaaagccctacctg gcctcctcagccactgtcggtaactgggtaggagacgggaactaaatgacccaaattggg caaggattcatcttaagatctggagagattccccacgaga >IGR2215 a ggagcacatcccacttccacatttccagaaagtaactggcagcctctgcagcctacagga catggtgtcttcactcagatccttcttaaaagccctacctggcctcctcagccactgtcg gtaactgggtaggagacgggaactaaatgacccaaattgggcaaggattcatcttaagat ctggagagattccccacgagagtccatatttcccacaacagcctccacaattgttttcat tctccttttctgaggttccatcccattaagaattgtgacatgcccattttttccatctaa cacaagacatatccttttcactctctgatgacataggctttgaattttgtctgaggcatg tctgtaaacaagaggcccaatggccacttcaagaagctttgtctggaagcctcaggcagg tctcttttacataccacagcattatggacatgatggtgaccatccggatattccaggttc gaagcagatccagaatgttgtgggactgctgcttcttggaacttaggtcttgtaactgca ggaacaacatcataagtgtatgggaagaagaggtggtcagagactcagagcacacaataa catacttgaatccctggcatcttagctgtctgcatctcagcgtcggggagtgttacgttt ctaagaacagtaagtatactgactgtgttttaggctgtga >IGR2216a gtgggactgctgcttcttggaacttaggtcttgtaactgcaggaacaacatcataagtgt atgggaagaagaggtggtcagagactcagagcacacaataacatacttgaatccctggca tcttagctgtctgcatctcagcgtcggggagtgttacgtttctaagaacagtaagtatac tgactgtgttttaggctgtgaaaacttccctaggccttgtcagtaacaaatcagagtgaa tgaaaatgaggaaaagtaagtgaccagtccctcaagggtacaggaagacagaggcccagg ctgacagcttcctcactgcacccccacatattcctgtcggtggccacattccaaggaggc ctctaagtattcctcccgaagcctggctccctgccctctgggtcagagagagtacctggc tgtgtggtttattggtctgatattttttaaaagttaatgttttgagtccttatactatgt agttactggtgtgcttccagggaaaaagaattcaaatagaaaaacaggaaaattgacctg agcttcacccagagtgacttcctatgaaattcagcacagccaaggccattaataaaccac acgtctaaacacactgatgttgctttcttaagcaaacccaggtttggagcttgtttttcc agagttagaagttcaacaaaaggtcaactttggactgaaa >IGR2217a gggaaaaagaattcaaatagaaaaacaggaaaattgacctgagcttcacccagagtgact tcctatgaaattcagcacagccaaggccattaataaaccacacgtctaaacacactgatg ttgctttcttaagcaaacccaggtttggagcttgtttttccagagttagaagttcaacaa aaggtcaactttggactgaaagtatcccctgaaatagcctcatttcctcaaagatgccag tggggcttatgcattcacccagattgacccctcacttaaaagcccccaaaaccacctaac ttaaaagccctctgccacactcctgcctgacctttgcgcacaggacccctttctggtgca tgctgacagtggctgctgggccaccactcactgggaagtctgcagggctggcagtggcca ttggcctccgctgtctacaataactgttccctcttttccaagcccaaccatgcctgcctc tcacacttcagcagggctgcttgtggctgttcccacacccaacccctcatcttccagtca gaccacagacacattccagaaccccaccaggcagcatttacagcttctaacctctcatag tcacgagaccaaggaaaactgcctgctacagagatggtaggagagggaacgggaaggaaa agcaagaaccaggaactaggtagagccaagaaatgagtca >IGR2218a cttgtggctgttcccacacccaacccctcatcttccagtcagaccacagacacattccag aaccccaccaggcagcatttacagcttctaacctctcatagtcacgagaccaaggaaaac tgcctgctacagagatggtaggagagggaacgggaaggaaaagcaagaaccaggaactag gtagagccaagaaatgagtcatggtgtgtgagaacagggctgacgggaggggtggggtag ggggaagaggtggacatcaaaaaggacctgactccaagatgatatgcaataattaaccat tggagggcagaaagagactaaacactttttttttctttttaatgaataattgctaatact caagagatgaaatacttctaactccaaatctatttgtgctttacattttacgtttggggt tagctttgtaaggtgacaagccaccttaggtataagaaacaatgattttcccaaatgctg actttatgaaaggcctattactcaaaaagagtatttattgttagaagtaatggttaaaat atatgattgcctagaaaggaagtaaaaaatgaaaatctgaaacccgtggtgaaaagagtg aggcagctgtaacctattcctcaacttctgagtgttaacagggcccgtgtgggggtgggg agtggggggatggggggaatgggcagttggggcttgggca >IGR2219a actcaaaaagagtatttattgttagaagtaatggttaaaatatatgattgcctagaaagg aagtaaaaaatgaaaatctgaaacccgtggtgaaaagagtgaggcagctgtaacctattc ctcaacttctgagtgttaacagggcccgtgtgggggtggggagtggggggatggggggaa tgggcagttggggcttgggcagagagagggctgggctgctgtgagcagggaggacttcag ggctgggtgctgctgctctcaaatcacggtcagtctgtccctctcacccacacccacatg gtgcttacctcactcgggtcaaagatagtggaaggcacaacaatcccattggctttggca gccttgcggatgatcacctctgcctcttcaaatcgtccctgagagatgagccatcggggg gactcagggatgaacctggcagtacaaggtccaatctcagtgaggcctccctgccaacag cagacccacagaccaggtagagcacagccataggtgggaataaggttgcagaaccagagc ttgtggaatgtttggtgatcacaagccagaagcaaagagctgatccacacgcagcaataa cctggggtggatgagcttatgtgtaccccacaccgcacaaaaatgggagagccctgcacc ccctgacggcatccccatgctggctggccacctccatttc >IGR2220a gagcacagccataggtgggaataaggttgcagaaccagagcttgtggaatgtttggtgat cacaagccagaagcaaagagctgatccacacgcagcaataacctggggtggatgagctta tgtgtaccccacaccgcacaaaaatgggagagccctgcaccccctgacggcatccccatg ctggctggccacctccatttctgaagagcagtgttgccatctgctgggctgaggagatgg gtgcaagatgggctccggaagcctggcttctgtgcatgtctatgtcagcccaggccctgc tacactctcctccctgtccccggcaccaacagaagcttctgcactggccttttagcttct cttctctcctcaccctacccctgatttatccaacagattagtcagatactctacctaaaa tagcatgtttggccaggtgcagtggttcactcctataatcccagcactttaggaggccaa ggccggtggatcatttgaggctaggagttccagaccagcctggccaacgcagtgaaaccc gtctctccaaagaaatacaaaaaaaattagccaagtgcggtggcaggcacctgtagtccc agctactcgggaggctgagacatgagaatcgcttgaactggggaggcggaggttgcagta agtggaaatcacgccactgcactacagcctgggcaacaga >IGR2221 a gctaggagttccagaccagcctggccaacgcagtgaaacccgtctctccaaagaaataca aaaaaaattagccaagtgcggtggcaggcacctgtagtcccagctactcgggaggctgag acatgagaatcgcttgaactggggaggcggaggttgcagtaagtggaaatcacgccactg cactacagcctgggcaacagagactttgtctgagaaaaaaaaaagaaaaaaaaagaaaaa gaaaagaaaaaaaggaaaaaaattagcatgtttatcaaggcacttgagtgctctatggat attattttccaccttgctgggaccaggtagccgccccccaccctcggtcatgactgggcc ccatgatgtgcggcttactctcccactatgccctgaaatgctctctgctccacttgggct ggtgatctcaccttctccacctgcaaggggtgattcccaccttagcacctctgcagtgtt cccctcttggtctggaatggcctcttctctgcctgttcaactcctctaccttggtggtgc agaaggagcctggcttcctccatgtggctaccctgaggactcttgcttttggtgccagtg cctgtggcatgaggcttcagcagcacacagccagaactagggcctacactgtcctgccct gaggcttgggaacttcctacagggcatgctggaccccatc >IGR2222a gcctcttctctgcctgttcaactcctctaccttggtggtgcagaaggagcctggcttcct ccatgtggctaccctgaggactcttgcttttggtgccagtgcctgtggcatgaggcttca gcagcacacagccagaactagggcctacactgtcctgccctgaggcttgggaacttccta cagggcatgctggaccccatcttctcacagctactgctatttttccccacacttggggca acccagcacagggctgagagcaagtctgttgctgtcatgggattctgttttgttttggct cttttgagtgtggagaaaacattctgaaataatttataatctatgcttcctgtctctggg agacaaaatagggattcatgggttgttgctgccctctagtgaaggccagacagaaatcat cctgccagtgggcacatggggcacagggtcacactcaccaccagagtgccacgcacagca cccccggcatcgtcagcgccaccagcagcatccgccagtctcggatgaagtaagcaaaca gtggcagcaccatgtagccaaatgcataaaatatgcacactcctaacgtagagaatatta tacgaactgacttgccaagaatttctgtccctgttcaaaacaagggaggtcgagttagca gtttaatttgggttccttccttattaattttttatggtat >IGR2223a caccagcagcatccgccagtctcggatgaagtaagcaaacagtggcagcaccatgtagcc aaatgcataaaatatgcacactcctaacgtagagaatattatacgaactgacttgccaag aatttctgtccctgttcaaaacaagggaggtcgagttagcagtttaatttgggttccttc cttattaattttttatggtatctttgtgaatacacagacaagaaaacagcgagaactctc tctaagttcatggcgctagggagcggatggcgttctgaacccctcctgtctgactgtctc ctgggggtacatccctgtggcctctcaggcccccaagcaacagttctctcttgaaaattt cgccatgttctgaagccatgtgctaaagatgccatggtaggccccctttaatcctcacat -ISI
gaggaagaatttattaaaagtgaagtcattactaagtcagcacatgctgacttaagcctc aaggaaagaatattaaatataaaaagaaaaaacaaccctttcaacaatacaacccaagga actcaaaggccttatcagctagagtcaggttcctccaaacacaggccggcctggcagctt ctcagtgacaacaggctggcacatttgagacaaagccctgcagtgtgcactctgaattaa aaccctgaaggtgacgaaagccccttcctatcaatttatt >IGR2224a taaaaagaaaaaacaaccctttcaacaatacaacccaaggaactcaaaggccttatcagc tagagtcaggttcctccaaacacaggccggcctggcagcttctcagtgacaacaggctgg cacatttgagacaaagccctgcagtgtgcactctgaattaaaaccctgaaggtgacgaaa gccccttcctatcaatttattcttgtccgtagatatcaccagccacagtgctctgcagac aaggggttctctaccttagcaagcttgccagtcacagcccctcctcctccaaccatgccg ccctctttctggggctggctcagccctgtgcagtggcaggccctttttgtaaatggagga tctctggtgagtcctagtaaattgactaccaagtactaagaccaaggagccacagcccag aggccagaaaagaactggaaatcagaagtcaggccattgtgctgctggggaccccaggct ggtctcatgtctggctcagtttccctgcctgtaagtaaggttcaccaggaagctctggct agttttgttagaaaccctgtcccccttgagggacatcacagctgtctccagaaaggtagg tgatgggatgatggtgaaatacaggatcaagtactcaactccaacctgatggccataccc aggacaaatgctgccacatagttggagatctggcccatgc >IGR2225a tttccctgcctgtaagtaaggttcaccaggaagctctggctagttttgttagaaaccctg tcccccttgagggacatcacagctgtctccagaaaggtaggtgatgggatgatggtgaaa tacaggatcaagtactcaactccaacctgatggccatacccaggacaaatgctgccacat agttggagatctggcccatgcctacaaggacaaacagcacgacaaacatctcaaaattct tcgagaagatctgcaggaagctgaagcctgtctgcatgcccatggtcacgaacagcacat tcttccggccaaacctgggaagaaaaggagagtgacagataaccagctggaaaagggcag caggaatgggctccaccaagtggggctttctcaagatccatccagtaagtgggtgtgaac agtgttgccagaatactggctgccagggacagtctcggtctcacagtgcccatgctattt ctccccctccccactccccatgacaaatgtacagcctgggtaccagggttgcctaaaaag caatgctacaattatgataatgattgcaagagactgaaatacatcaattatttaatccat acattcataatgatattttttttaaaaaagaatctgccaaatttggagaataacagagaa acaattcattataaatgaaaactggcaaataaagagaaag >IGR2226a atgacaaatgtacagcctgggtaccagggttgcctaaaaagcaatgctacaattatgata atgattgcaagagactgaaatacatcaattatttaatccatacattcataatgatatttt ttttaaaaaagaatctgccaaatttggagaataacagagaaacaattcattataaatgaa aactggcaaataaagagaaagaagcatttgtcctgattttcctttgtaaactatgtgaac agcaaccaataatagataagaggtagtatcatgtacaaaagtattctaacttttaaatga aaaggtaataaaattagaataataccatttatagcccccaatggattaatagatctatgc attatatactaattactgttaacatcataaagagacagtcaggaattgcatgcttcctat ggtcttgccaaaaggactgaacctgaatcagaacctgaatctcaagtctctggatccaac tgccaattttgaggaaatgcagagcatagaggaatgtgctgaactgcatcatcagtgtgc aatcaacaaatccagactgggaaattctataggtggaatagctcaggttcttcatagata atcagtaaggcatagaaggcgatagaaggagaatccatagattaagtagactaaaagaca tcaaatatattaagtgggcaacactaaatttgtgtcaagg >IGR2227a cagagcatagaggaatgtgctgaactgcatcatcagtgtgcaatcaacaaatccagactg ggaaattctataggtggaatagctcaggttcttcatagataatcagtaaggcatagaagg cgatagaaggagaatccatagattaagtagactaaaagacatcaaatatattaagtgggc aacactaaatttgtgtcaaggatgcatatttcgataataaaactaaaaaaactcacaagg aagtgattattacaggagtcaggctagcggttacttaatggggagagagagaggatgctg taattgggatggggcacatggacagggcttcttagtggacagcaaagttctactgctcga cttggtggtggtcataaggttatttctctgaaaaaaattcattaagctacacatttgttc tgtgtggttttctgtatccgtgctcattttaaaaagtttttaaaattgggtttattttgg tttgttttaaagagagtgccacaaacaggaggaaaaagtcaagctagtgggaagcagtgg gttcagtttgagtctggccagtactggctgacacccactttcattcaatgtttattgagc atctattatagagggcacttggatatcaataaattaaaaaagatgctgtttctgccctta aggagtgtcatagtataactggtgaaacacatattaacca >IGR2228a cacaaacaggaggaaaaagtcaagctagtgggaagcagtgggttcagtttgagtctggcc agtactggctgacacccactttcattcaatgtttattgagcatctattatagagggcact tggatatcaataaattaaaaaagatgctgtttctgcccttaaggagtgtcatagtataac tggtgaaacacatattaaccacattttaatctaacaacacgctactgaatatacaattac acactgagtcaagtgcactgaaggatcggcatgcaggttaatgagaggcacaaggaagga agctaccctggactgggggtaagggttggggaactggacattcagggagggtctccttga tcatgggacactgagatgggaaaaaatagttgacgatgggggatttaaggtgtagggacc aagctctcaatgatattcacagtatagtggggaagaccaacattaatcctataataacac tttttttcccccaatttctggtagacgttttaaaggaaagtcataaggaactagggatcc tgaattagccagcatggttaaagaaggccacagggggtgggttggggtgggtggggaatg cttcagactctgagaagaccacacacccccatggctggagggggcatggtgaacatgagg aaccagtgtggttggcatcaggcgtgcaattcaagagtac >IGR2229a ggtagacgttttaaaggaaagtcataaggaactagggatcctgaattagccagcatggtt aaagaaggccacagggggtgggttggggtgggtggggaatgcttcagactctgagaagac cacacacccccatggctggagggggcatggtgaacatgaggaaccagtgtggttggcatc aggcgtgcaattcaagagtacagtggtggctaggaggcaaattgcacaaggtcttgcaac tatgtggaagagtttggtgtttttcctcaataaaagaggtttttttctgttgttgttttt tttttccatcacttggggttcactggcatctaatgagtagaggccagatatgttgttaaa tattctaaaatgcccaggaaaatgccctagaacaaaattatttggctcaaaatgttaata gggtcgaggttgagaaactctcgcctggtagtagactctactttcccctgcatggttttt ttaacaagcatgttctatatgccaaccaaggggtggttcctaaccacaaggcaggctggt ataatctctatgccctttcccttcctaagagctccctgggatggtagggaagagacagat ccagagaaccctttacatagcaccagtccttggcagttcagggttggggccagaaatgtt tgcttttaaagtctgtcaacaaaatggcaaacacacacat >IGR2230a tgccaaccaaggggtggttcctaaccacaaggcaggctggtataatctctatgccctttc ccttcctaagagctccctgggatggtagggaagagacagatccagagaaccctttacata gcaccagtccttggcagttcagggttggggccagaaatgtttgcttttaaagtctgtcaa caaaatggcaaacacacacatacctggaaacaggacacagcagtctacttcttcctagag ttgtgcatctcttacaagtcagacgcataaagataactcaatagtgttacataaagggct ttgacaacccaggagtactttaattgctcttgaatttcagacatattcataggccagaaa gaaggtgaaacctttatactatataaaaagttacattgatgtcctagacaagttagggca tgaattgattgctttcaggtaatctacttagcttaggttttagaactggtttactcagaa gtaatgcactcagaagctgtccatcccacagggccctgggccttccaagggggcacagac aggcttgaggcagggcattgggaattgaaggcaggggctgcaggcagaacagccatactt ttagccacttagggtgtatttcatttactagacttaaattatcctactttaatgaaagtt ctgtggccaaaatgtttagaaaggtttgaaaaacactata >IGR2231a tccatcccacagggccctgggccttccaagggggcacagacaggcttgaggcagggcatt gggaattgaaggcaggggctgcaggcagaacagccatacttttagccacttagggtgtat ttcatttactagacttaaattatcctactttaatgaaagttctgtggccaaaatgtttag aaaggtttgaaaaacactatattagcccttctgtagactaaagtggtcctaaacacactc acaaattttgtttccactttccctgggaatagaccttttggaacttaaatgctttcctca ggtaatcattgtgtcacatggcaagaaggttcttaagctgacccatgacacagctgaccc agaaaaatacactgcatttctactctgaacttggggtatctccttttcacatcaagggca ttcttctgagccgcagctgtcacttagctccgtgagaaggaatctcccatgtccactcag gtggcctctaagcatagcacaatcctcccccagttcccccctcccctccccactcccctc tccccaggcaacctcatccctatctggggctctgctgagggttctatatgctgacaaatc ctacatgtgtttctctagccaaaacctctcatgcagtaccatatccatacagccagcttc acactctacttctccacttaggggtctcatagtcacccca >IGR2232a caatcctcccccagttcccccctcccctccccactcccctctccccaggcaacctcatcc ctatctggggctctgctgagggttctatatgctgacaaatcctacatgtgtttctctagc caaaacctctcatgcagtaccatatccatacagccagcttcacactctacttctccactt aggggtctcatagtcaccccaaatttagtacacacaaattgaactcaatatccatgaacg tggttcttttccagcattctctgtcttagagaagtgtaccttcattcacccagttactca ggccagaaagctttcttcccccaattccgacatccagcccatcggcaagtcttgttgatt ttacctcttaccacttccctccatttctaccaccgtcatgctaggccatgccaccatcat ctctggcatgaactactgtgacaaccttttaattggtctctctacaacaccttttgcttc ccttcaattctttcttcacaaggttgtcaaagcatctttaaaaaaaaaaaaaggacaaat ctgattgtcacactattgctttaaaaaatctcagtagcccaccgctgctctgtggctgaa gcccaaagtcctaactgtgatccactaagccctggttgctcatctgcccagggctctgcc tgcctctccccttcatcttaacaccactctccgcacctct >IGR2233a aaggttgtcaaagcatctttaaaaaaaaaaaaaggacaaatctgattgtcacactattgc tttaaaaaatctcagtagcccaccgctgctctgtggctgaagcccaaagtcctaactgtg atccactaagccctggttgctcatctgcccagggctctgcctgcctctccccttcatctt aacaccactctccgcacctctaccacacggactttgtcctgctcccatgccttttcatga gccccggctttagcacttgctattctccctgcctggatgttctttctcctctctacccct cagctggctactttcgactcatcttcccactctcgctcatgcttcaccttctcagggatg ctgcccctgacctcctctgttagacactcctgtggcaccctgcacttctctgtatctctt accatggccaaggacaacaacgacttcctcacttggttgtttaatacattccaccttgct agaaagcaagttttaggacagcagggacctagaacagtagtccatacacaatagaggagc aagactacctgggtccaaatcctaactctgccacttgccagctgtgaaaccttggggaag ttatttaatccctctgtctcactttctccatctgtaaagtaggaataataaacaggttaa cctgctttttaaaaaaaaatctggctgggcaggtgcagtg >IGR2234a agcagggacctagaacagtagtccatacacaatagaggagcaagactacctgggtccaaa tcctaactctgccacttgccagctgtgaaaccttggggaagttatttaatccctctgtct cactttctccatctgtaaagtaggaataataaacaggttaacctgctttttaaaaaaaaa tctggctgggcaggtgcagtggctcgcgcctgtaatcccagcactttgggaggccgaggt gggtggatcacctgaggtcgggagtttgagaccagcctgaccaacatggagaaaccttgt ctctattaaaaatacaaaattagctgggcatggtggtgcatgcctgtaatcccagcaact caggaggctgagacaggagaatctcttgaacctgggaggcagaggttgcagtgagccgag atcgtgccattgcactccagcctgggtaacaagagtgaaactccttttccaaaaaaaaac aacaacaataaaaaatatctggctgcgcatggtgtctcacgcctgtaatcccagcacttt gggaggttatggagggaggattgcttgaggccaggaattaaaaaccagggaagatgctgg gactcctttccaccggctaacccaccgatttgtggggtgttctcacatgtgccatgtggc caaggacttgctgaaggctgctactctcttcacagtcttc >IGR2235a tggctgcgcatggtgtctcacgcctgtaatcccagcactttgggaggttatggagggagg attgcttgaggccaggaattaaaaaccagggaagatgctgggactcctttccaccggcta acccaccgatttgtggggtgttctcacatgtgccatgtggccaaggacttgctgaaggct gctactctcttcacagtcttctctgacagaccctgaagctccagggaaagaagacacaac ataatggacccctctaagaacttcatgaaagctacggacctctctccaaaaaaatgctca catgtagtctctaacattgtgcatataatttcgaggggtttgggattctctaagccgtta atgtttccttgagttaaaagctttagaattatacaaataacctgcttataagaaatggat caaaacactattctccctcctgtcataaagtaaatgccaaaaccacaggccacttagcta aggggcatcagccttgtggacaaaagagttctgcttttcataccactagtggctggtgag agctcctttcactttgcagagagaatgctggtcttcttgggactacagaggcagacaccg tggcactactacagatctacaatctagcacatgtgcatgtgtgcatgatgtcaacctctc ccatgctcaggggcatgacagagtcacagtgacccagggg >IGR2236a acaaaagagttctgcttttcataccactagtggctggtgagagctcctttcactttgcag agagaatgctggtcttcttgggactacagaggcagacaccgtggcactactacagatcta caatctagcacatgtgcatgtgtgcatgatgtcaacctctcccatgctcaggggcatgac agagtcacagtgacccaggggaggcaagccaggctactgcagaagtgaatcatggcatat tacctagtcaaccggatcacagatacattcagcttagacagctcaggtttctttacttag caagaattacggagtcagatgatttgttggctcttcttactaggcatggagtctatatca cagacatagcttcctcttctttaaaatacagggccctgcgctgaaagaatactaccaact gaaatcaagggccaggcacacgcttcttcctcagtgctgaggtcccctggtgctccagaa gacagacaccttacctgtctgacagctgccctgaaatgaaggagcccaacagcacaccca cgaagaacaaggagattgtgagtggggccttccagtcgtcctcacacaccaggttccact gcaagatgagcaaagggggtgtatcattcacttctttttaaaaggttttaaagcaaaggc atcctggaaaatgaagtcagaacatcctgccatccccaca >IGR2237a tgacagctgccctgaaatgaaggagcccaacagcacacccacgaagaacaaggagattgt gagtggggccttccagtcgtcctcacacaccaggttccactgcaagatgagcaaaggggg tgtatcattcacttctttttaaaaggttttaaagcaaaggcatcctggaaaatgaagtca gaacatcctgccatccccacacgctctgagtgtgaactcacttagtcaggtgatggctca cctgggcaggaaggcagagagcaggcttctttcccatcctgtttttcatagcattgtagg ccccactgtcttgcttccattttgaggaggagagacaggcagagagtaagtgttctgtcc acatgctgaccctggagaaagcaaggcctctaacgcttgctcctaaaaatctgagcggag cccagggctgtggaagaggcagggcaccctcgctcagtggggttcaggccattggcatga acgtcactggagtggttctggaagcagggctctggggctctacgggccaaagcatccagc aagaaactaaggccagggcacagagtgcaccatctggacctgctctgctcaggttcccac cctgggccaatgacccccgggtcctttttgtgacctttagagctggaatccctgatgctg cacaccaactatactaggctcaattacagctgaaagccct >IGR2238a ggaagcagggctctggggctctacgggccaaagcatccagcaagaaactaaggccagggc acagagtgcaccatctggacctgctctgctcaggttcccaccctgggccaatgacccccg ggtcctttttgtgacctttagagctggaatccctgatgctgcacaccaactatactaggc tcaattacagctgaaagccctgagcttggaggtaagaaactgggttttagctcccactct actattaactcttccaacctcagataagcatcaccccatgctgtgccttgatttccccat ttgtaaaacagggattggggtaaggaataggctgcaccgcttgagtttccagcttccaat gtgtggttccatctatagttaccatgaacagaaaaagaggtctgaagacatggggaagca gccagacgcttggatctggctacgcctgcctaaacaagagccaaaagcaggaagaaagcc caaacgggaaacttagtggttcacagaaaaatgaaaaatgtttttcagacagagagatgg tgctcagtagtaacctttgcagacttctcacatgagcaaccaccctcctaggaactcaga cccttgcctccctggtgccaggctgctagcctgccctccacggagcctgctggctcctca ccaacaacgcaggcaaggggacatgcggctccctagaaca >IGR2239a ttcacagaaaaatgaaaaatgtttttcagacagagagatggtgctcagtagtaacctttg cagacttctcacatgagcaaccaccctcctaggaactcagacccttgcctccctggtgcc aggctgctagcctgccctccacggagcctgctggctcctcaccaacaacgcaggcaaggg gacatgcggctccctagaacaaagcatctcttccaagccagtgacagggaaaaacaagcc tgcttctccgcactgctgggcagtgtgggcgcacagcctccgggcacctctcagaggggt tggcaggcaaccctcaggctggacacggagaactcccgcagcaggcacactgctggtgct ccgctttggaataagcgtgaacctggatgggctgggagtagggtggcaatccccaaccca gggaagaactggagcatccaacccctaatcaggaggcagcccagactagcaggagtcaag aacatgggaggaccacagcctgactgcccaggctgccacagcctccaacctccacagcct cagaagggccagcacccacaggccatctctctggtaggtgggtaagtatccctgcagtgg cccccacccacacatggctgctaaatctaggactgggagtggaggcggagaaaaagctga gggaattgatgacagggtgccggcctctgtgtgtgaggcc >IGR2240a ctgactgcccaggctgccacagcctccaacctccacagcctcagaagggccagcacccac aggccatctctctggtaggtgggtaagtatccctgcagtggcccccacccacacatggct gctaaatctaggactgggagtggaggcggagaaaaagctgagggaattgatgacagggtg ccggcctctgtgtgtgaggccaagcttcaggggccaggacctggctcctgccactcttga gtatgatgggctctatttcccagctagcatgtcttttatagtggaaaagatgaaaacatg aacaaagggtcagcagcggtttctcacaggactatcatgaggtgagggttggggacccat atggctgagctagactagcaatccacgtgggcttctgcagtgagttctggggttgtagac cccaggacaggtctcccaatatcaggcttctaaagactccttggctggcaaggttgggtg tgacctaaaaccaggtcagacaatctctgcaggggacagggtgactatagtgctcatttt gagacaggccccagagcatctctcaggctcccttagccccaccctctctacttggtccag cctgtccttagtctaggcaggtgtgtaactccttggttaactctgccatccacccaccac tgaccgcccttgacaactctctgggcctggctttgggccc >IGR2241a acaatctctgcaggggacagggtgactatagtgctcattttgagacaggccccagagcat ctctcaggctcccttagccccaccctctctacttggtccagcctgtccttagtctaggca ggtgtgtaactccttggttaactctgccatccacccaccactgaccgcccttgacaactc tctgggcctggctttgggccctccaaaagcaaatatgcattaacacttctttcctattgg ccgcagggggtctgtgagcaggatcaggaaaggtgctaggtctcaaaactgaacacaagg gcaaacatagattgggtcccagcctgccaatccgtccacatatctgtcaaccaccagatg gactgcagtaggttccaggacttggccagaatctccctgagaagaggtggatgagaagca catagagtccaggctaagtaccccctacttaaattgtttacaaaggagtctagcattcct tagctcctggctccccagctgtgattaaagctgctacagaccagcttattgatgcctccg cctggcacatgggatgggctatactggctgatgatcacaggtatcaatgttaaaatggaa tgtgtgggtttaagatttgggtcacgagtctaatgctgtcacccttcagctggctgagct gtgaatgcaggcccaacctgaaaacaatctgggagcaact >IGR2242a tgtgattaaagctgctacagaccagcttattgatgcctccgcctggcacatgggatgggc tatactggctgatgatcacaggtatcaatgttaaaatggaatgtgtgggtttaagatttg ggtcacgagtctaatgctgtcacccttcagctggctgagctgtgaatgcaggcccaacct gaaaacaatctgggagcaactctggcaaagggcctagacttgcccctcttcctggggaga aatgcacctttctagtggtgatggtttcaagggtgtagagatacatgtgtgccaaattgc atgctttagctacatgcagtttttatgtcatttacaccttaataaagctattaaacattt ttaaaaagagggagaattgtgtctcctatacctcatacataattggcactgctttttcag ttatgagaagtagagagatgacatagttccctgggactaaatgttcttacctgtgaattg gcaggaagggaaaaaagatagggtgtgtgcccctaagacagaagttcttccctgagggga tgtacctagcctgaccgtatcaacagtcagacatgctgctaggtaccacatgttactgat tgccatgtattcctatattcctacacacattttatcctgcctcctgctgaaatcaatgat gaatccttgccccaccgttgtcagagcaaagagaaaaggt >IGR2243a agggtgtgtgcccctaagacagaagttcttccctgaggggatgtacctagcctgaccgta tcaacagtcagacatgctgctaggtaccacatgttactgattgccatgtattcctatatt cctacacacattttatcctgcctcctgctgaaatcaatgatgaatccttgccccaccgtt gtcagagcaaagagaaaaggtatttcctatctttgctatcacatcctctacaactcctgg cagtgccccctgtatcgaagagaggctcaggagctctttggtacataggtgagtgaatga atcgataaataaaaaggtatcaaccttcaacatcttggtatactttagttcttgcttggc tgcccaaagtcgagatgaaccctgaactcctgaacttcaatctccagaatactctttttt ttcttttgaaacagagtcttgctctgtctcccaggctggagtgcagtggcacaatctcgg ctcactgcaacctccacctcccgggttcaagtgattctcatgcctcagcctcctgagtgg ctgggactacagggatgcaccaccagcctggctaatttttgtatttttagtagagacggg gttttgccatgttgaccaggctggtcttgaactctgacctcaggttatctgcccaccttg gcctcccaaagccctgggattacaggcaagagccaccaca >IGR2244a cccgggttcaagtgattctcatgcctcagcctcctgagtggctgggactacagggatgca ccaccagcctggctaatttttgtatttttagtagagacggggttttgccatgttgaccag gctggtcttgaactctgacctcaggttatctgcccaccttggcctcccaaagccctggga ttacaggcaagagccaccacacctggccatttttttttttggctccctgaccccctgctt tgtgtcaactgtcagaaatttgacccaggatgacaggtgtcagctagctagagagtggct caatctgaccactcatggccagatgtgtctactatgtacgtgcatagtgggccacgggac cccgcaagtggcttctctgccttgccatatagctgcaaaaggctggatgagggtctgtgt gtcccctgagtgagagaaatcaacaaaggcgtaacagtgaggttcaagttccaggtctct cgggtctctgctgcccagagtcagccccggtcccagctcccaggttgctctggcttttcc tccaggcagctttggggataacagtgagggctctctcatcttctaagactatctgtctct acacaagataaggctgatagaaaagctagtccaggacaatggggagggagtgggagtccc acccaggactgggccgagggcttcttagaagcagacaggt >IGR2245a gtcagccccggtcccagctcccaggttgctctggcttttcctccaggcagctttggggat aacagtgagggctctctcatcttctaagactatctgtctctacacaagataaggctgata gaaaagctagtccaggacaatggggagggagtgggagtcccacccaggactgggccgagg gcttcttagaagcagacaggtggagagcaaggcgatgcagagcagcttggaagtttcttt tctttttctttttttttttttgagacggagtcttgctcttgtcacccaggctggcatgca atggtgcgatcttggctactgcaacccccacttcccaggttcaagaaattctcctgcctc agcctccctcccgagtagctgggattacaggcacccgccaccacgcagggctaatttttg tatttttagcggagacgaggtttcaccatgttggccaggctggtctcgaactcctgcctt gtgatccacctgcctcagcctcccaaagtgctgggtttacaggcatgagccaccacaccc agccggaagtttctcaaggaacctgtctgtccataggctggacagagctatggtgaaacc aaagagcggacagcccagacaacctcagaaacaacccaggtttccagcagatggggcagt ccatggccaagaagcactgcatgatgggttggctaattcc >IGR2246a ctcccaaagtgctgggtttacaggcatgagccaccacacccagccggaagtttctcaagg aacctgtctgtccataggctggacagagctatggtgaaaccaaagagcggacagcccaga caacctcagaaacaacccaggtttccagcagatggggcagtccatggccaagaagcactg catgatgggttggctaattccccagtaccccagggatgactgaggggccagaggagaggc cagccgagaaccatgtggaccaccaaactattcctggaacatgggggcataaaactcttt tacctcataaatcatttttatttattaatattattattattcttttgagatggagtctcg ctttgtcgcccaggctagagtgcagaggctcgatctcggttcactgcaaagcccgcctcc tgggttcaagcgattctcctgcttcagtctcccaagtagctgggaatacaggcatgtgcc accacacccagctaatttttgtatttttagtagagatggagtttcaccatgttggccaga ctggtcttgaactcccgacctcaagtgacctgctgccttggcttcccaaagtgctgggat tacaggcgtgagccaccacgccctgccaatatttatttatttattaattgctagcagatt ccctctgccaatcccaacacctcattccacatccatgtgg >IGR2247a tgtatttttagtagagatggagtttcaccatgttggccagactggtcttgaactcccgac ctcaagtgacctgctgccttggcttcccaaagtgctgggattacaggcgtgagccaccac gccctgccaatatttatttaritattaattgctagcagattccctctgccaatcccaaca cctcattccacatccatgtggcatcaaagccccagtcagtgggcagggggagtcacattt cctttaaaaaattccagtcaatccttttcagccaccctcaagtttcccttctaagaactg aactatttttctttagttctcaaactttagagatgatttcttaaattattcattaactca ttcaataaaaattttcctgagaacctccctctgcatccagaattgtgtcagaaattgagg aagacgcaaagatctaaatccaccacaaagtttggtactacatgtatgtactttaacttg aacaaattaaaaaaatccaaacaggacacctgaggttccagtcttcagtggaaaaaatat gactagtaattcaataccagtgtacttacaaacacctttatgtatgatttggggcagagg gcaggcttagagacatttagcaggcatgggactagatgcagtgttcagcaggccaggttt gggttgaaagacaacaggccatagaaaaagccattagaat >IGR2248 a aacaggacacctgaggttccagtcttcagtggaaaaaatatgactagtaattcaatacca gtgtacttacaaacacctttatgtatgatttggggcagagggcaggcttagagacattta gcaggcatgggactagatgcagtgttcagcaggccaggtttgggttgaaagacaacaggc catagaaaaagccattagaatgttgatgcagcaacttccagcagtagctgttcacctggg aacaagcagctctgaacttcaagtcaagcattccagtagcccaaaacaaagatctaagca ttaatctggcctccctgcaaagactgacaacatataagtaggtgaaagggcacataactc ctttgaaactgctaagacagctaaataaatagtctaaatattaaaaaacaaaaggctgac attggcagcaagataaggtcagaccccctggcacagctggcctttgggagctcatcaatg ccaccatcactcagcccaatgtgggatggaggcagcaaagcaggaacaagtgactagagt aagccggggaaccctcaggggtcaatgtaaaactccaagagatgccatgtgcttcttctt gcttcactacttccctcttctttaggcagccccaagtagaatttgtagggattcctgtgt catgttcccctctgtggcctctgcctgcaacctcagggac >IGR2249a tgtgggatggaggcagcaaagcaggaacaagtgactagagtaagccggggaaccctcagg ggtcaatgtaaaactccaagagatgccatgtgcttcttcttgcttcactacttccctctt ctttaggcagccccaagtagaatttgtagggattcctgtgtcatgttcccctctgtggcc tctgcctgcaacctcagggacagcctctgctttcatagtactcactggcttccgggaagg taacacacccacctgtgaggctaggacccaggatttgtggcaactgaaagttccaatttc ctgtggattcatgggccagaaagcacagttggctacctccaaggagtgcctcttttgtca agccatgatgcctctggacactgaagctatgtcactagctaagaaatcccagtggggctc cggtcacactcccactacatatatgtggagaaagcaggtccaaatgctggggacatcaaa tttccaaaaagaaaaaacacacacatgcacacacacttggatctcccagggtagctctca gactccattgaagggtgatgacgccaagaagcaacacagttgggatctccagagcccctg taagcccctctgaggctccaggaggggaggctcagcaccaacatccagcagggcttgaag ctgtgccagggcctgtggcactctccctctctatgaactc >IGR2250a cacacatgcacacacacttggatctcccagggtagctctcagactccattgaagggtgat gacgccaagaagcaacacagttgggatctccagagcccctgtaagcccctctgaggctcc aggaggggaggctcagcaccaacatccagcagggcttgaagctgtgccagggcctgtggc actctccctctctatgaactctcccctctctgtgaactccgccgtcctgctgggtggttt cttgctgctgcattggggccttcagctcactattatgctgagctgaacaccctaggctca ctgagaggcctcctcttctgggaagccttctctaacctgcgaattggtcatctgcacatt tagtgagcctatctatcaatgagggctactcactggctacttactcaatgctgctgaaac ttcagggagctagagtgccagtgtctaaaaaagacacaaaacacatacatcattaacatc atgttcctacatccagctccaacaactgctccaacaggttcggaggggacagacaaaacc acccagagggaaaatccaaggggatgagaaatgagaaaggctcccccacaccctatgacc taaggctgtatgctttaactaaatctggccgacagccttgcctcataatacctgagaaaa tattccaggtcaacaagtcaccctgaacccatcttcagat >IGR2251a caacaactgctccaacaggttcggaggggacagacaaaaccacccagagggaaaatccaa ggggatgagaaatgagaaaggctcccccacaccctatgacctaaggctgtatgctttaac taaatctggccgacagccttgcctcataatacctgagaaaatattccaggtcaacaagtc accctgaacccatcttcagatgaatggatcttaaagagtgacaactgacggcctggcgtg gtggctcacggttgtaatcccagctttgcaggcagaagcaggcagatcacgaggtcaaga gatcgagaccatcctggccaacacggtgaaaccccgtctctactaaaaacacaaaaatta gctgggcgtcgtggctcacagctactcggaggctgaggcaggagaatcacttgagcccgg aaggcgaagattgcagtgagccaagaacgcacgactgcgaaggttgcagtgagccaagaa cacacgactgcgctccagcctggtgacagagggagactctgtctcaaaaaaaaaaaaaaa aaaaaaagactgacaactgaccatgggaaaaggcaaacaattacttacagggcatgacca gattgtcgtttttgggttgtggacggtaggggaaggagtaactagaggaaaaagggaaga ggcagttgtatacacatgctttatttaacttttaaaagtt >IGR2252a ctggtgacagagggagactctgtctcaaaaaaaaaaaaaaaaaaaaaagactgacaactg accatgggaaaaggcaaacaattacttacagggcatgaccagattgtcgtttttgggttg tggacggtaggggaaggagtaactagaggaaaaagggaagaggcagttgtatacacatgc tttatttaacttttaaaagttcaggaaagagaagtatttcttctcttctaaaaagaaatc aagagactagaggaaaaacgggatagcccctggcccaagtcctggctctgctacttacca cccccaaccccaactagagtaagtcctggacacacagggccatagagcatcgcccaggga ccgccaggaccttcctggtaccctcttcaaagtggccatcaggacgggaggccagactga ccacctgtgcagggaggagcacactgtggctggaggtcacctcgtgaagcgttcccaagc cacctggctggagggtctccatcgctagggtgttgaccgttgggggagggggagtgacag cgtccagtgcgcatctgggagagaggagctcgggttcaaggaccgcgacaggtcctccga gccctggtctcagccccagcaggggccggcacccacctcggtcacaatggtggacaggta gacgtcctgactgaactcccagccatccagacagctctcc >IGR2253a catcgctagggtgttgaccgttgggggagggggagtgacagcgtccagtgcgcatctggg agagaggagctcgggttcaaggaccgcgacaggtcctccgagccctggtctcagccccag caggggccggcacccacctcggtcacaatggtggacaggtagacgtcctgactgaactcc cagccatccagacagctctcctgctccagctgccccaggtccacgtcgcgccccggctcc agcccgagcgccgagaagttggcgatggtggcgagccggtagcggcggcagctgtggggc acctcgcggccgtcccgcagccgcagtgggacagtgtggttgcgccaggcgctgctcagg ttcgcggcgtccggcacccggcagcggtgctccggggtcgctatcaggaacacggaggac aggccggtgaagccattggggatgatgctggcgctgagcaggaagaagatgaggcgctgg aagggcccccactcgcccaggaaggcggtcacctcgtcgtagtcccgcatgccgccctca gaggcccacagagcgcggcctggggtctgggaacgcggcgggctttgcgcgtgcgcgcgg ggcacccgccgccgaccaggcaagccaggcagcaggcgacccaagaccgtccgcggaggg taggctcgcgagctgacaccgccgccttggtcctgccgcg >IGR2254a ggaaggcggtcacctcgtcgtagtcccgcatgccgccctcagaggcccacagagcgcggc ctggggtctgggaacgcggcgggctttgcgcgtgcgcgcggggcacccgccgccgaccag gcaagccaggcagcaggcgacccaagaccgtccgcggagggtaggctcgcgagctgacac cgccgccttggtcctgccgcggctggccttacatatggcgcacgaccagggaaggttccg ggcctgggccgcaaggcgcgccccgctggcaggcagagcggcgccggcgaaggcggagct ggggcgggacgcgagggcgcggggcgggccgggagtgcacctgaggcccgggcggggcct gtcctggggacctggcgaggcccggcctctgccagccacgcctgctggggacgaccgagg tagcccggggtcggcttaggaaggcagcgggactcgaggccttggggtccgagtccgaac tcgctcctctagcgccgggcggggagcgagtgggagagcggccgcgaagctccagtgttg aaaacgcacccctcccagctttttgcaaggcctacttgggggcggaggtaaggagaaagt cactggcccagggtctcacagatagttgctcttgacaccgcctaatcttataagagggac ggggattattttgaacctgggactgttaactaccctagta >IGR2255a cggggagcgagtgggagagcggccgcgaagctccagtgttgaaaacgcacccctcccagc tttttgcaaggcctacttgggggcggaggtaaggagaaagtcactggcccagggtctcac agatagttgctcttgacaccgcctaatcttataagagggacggggattattttgaacctg ggactgttaactaccctagtagagaggctgggagctatgacttttcattctagtccagat gccctttccacattttcgtctgtaacaagccattttgttcatgcagatgtaaaaatttaa cttcacgattaacgatcctagcctagggttaaatattccccacagattagttatttccgt gcagagtttattcagaagctaactggaaaaaaaaaaaaagcagcgaggtgattctaaagc agcaatgttccataggataaggagctacatttgttatgttaacttttctagtagccatat taataaaattgccagatttagcaaataaaaatataggactcctagttaaatttgaatttc agatatagaatgaataatttttaaatattatgtcccaagcaggaatatataaaataaaaa tgtaactggttgtcctgtattttattgggcaatgctgcatatttaaaaagtaaaaataaa agatgaaattaactttagtggtatatttaatcaagtatat >IGR2256a agcaaataaaaatataggactcctagttaaatttgaatttcagatatagaatgaataatt tttaaatattatgtcccaagcaggaatatataaaataaaaatgtaactggttgtcctgta ttttattgggcaatgctgcatatttaaaaagtaaaaataaaagatgaaattaactttagt ggtatatttaatcaagtatatccagaacatgatcatttcatcatataatcaatatagaaa ttattgatattttacattgttatatgtaaatcattgatctttttttcccctcctcatact aaatcttaagaattcagtgtgtttcacaggttctcaggatttgaaaaaaaaaaaaaaagg aatccagtgtgtattttacagcacatttcaatttggactagccacactttttatttttta atatttatttattcatttatttattggagacacggtcccactgtgtcacccaggctagag tgcagtggcacaatcatagctcaccgcagccctgaactcctaagcttaagtgggcctcct gcctcagcctgctgagtagctaggactacaggcacatgccaccgtgcccagctaattttt ttattttttttattttacagagacaaggcatccctgtgttgcccaggctggtctcagact cctgggtttaagcaatcctcccacctcagcctcccaaaat >IGR2257a ctcaccgcagccctgaactcctaagcttaagtgggcctcctgcctcagcctgctgagtag ctaggactacaggcacatgccaccgtgcccagctaatttttttattttttttattttaca gagacaaggcatccctgtgttgcccaggctggtctcagactcctgggtttaagcaatcct cccacctcagcctcccaaaatgctgaattacagacgtgagccactatgcctggccagact cattttttaagtgctcagtagccacatgtagctattggttatcttattggacagcaccat tcctaaggcctttaagaatttgggctgctaaacttaacaatgcaagatattcctttttaa aatagtagtggcttagtgatagaaacagaactaagtgtatatttttacaatataatgtgt tgggtaaagaatatttaatagtcactatattatgagttgaaaataaagctacagaaaggg aacctaacctggccagcagatttttaataaggaaatctaaacatttgcataaagcataat agacttaaaaaaattatgataaagatgttatcacaggacttgtttgtttctttatactta ctattcactattcttacttcgtgaagatggatggttataccttcagcaatgtacttaaat ccttctaacatcttatgtgaagttatagttcttatctaga >IGR2258a atttttaataaggaaatctaaacatttgcataaagcataatagacttaaaaaaattatga taaagatgttatcacaggacttgtttgtttctttatacttactattcactattcttactt cgtgaagatggatggttataccttcagcaatgtacttaaatccttctaacatcttatgtg aagttatagttcttatctagaactaactgaaaaagaaagcaaagcttcttgaaaataaac tccttttttgtgtgctaaaatattattttaatgcttcaaaagaaatgaaagcttttatga gaagaatgttgacctctgtccagaccaaacaagatgaagaagtcttattttaacatttga gaaatatcagttgggcatcagataacattcctgaaagggactgaaaacaatgcagtatac tacaaaagaagctgcatatccttaggaagaaaagaaactatttgtcatagatggcttgtc cacatgcgcaaagcagagagcaacctaagatggtgccgtccagttccaggtgcactgtga ttactatctgaatgccattactatttaaattgcattttttttttgagacagggtctcctt ctgtcacccaggctggagtgcagtgaggtggtcttggctcactgcagcctcaacctcctg ggctcaagcaatcctcccacctgagccttccaagtgcctg >IGR2259a gcaacctaagatggtgccgtccagttccaggtgcactgtgattactatctgaatgccatt actatttaaattgcattttttttttgagacagggtctccttctgtcacccaggctggagt gcagtgaggtggtcttggctcactgcagcctcaacctcctgggctcaagcaatcctccca cctgagccttccaagtgcctgggactacagccacgcgccgctacacccagctattttttt tgtatttttggtagagacagggttttgccattttggccaagctggtctcaaattcctgac ctcaagtgatccccccgtcttggcctcccaaagtactgggattataggtaggagccacca tacccagccttaaatttcatcttttaaaagagaaagagagcttagaatcttaatcagtta cctgaggccctttatcctgcaatattctgaattgggatgttcctattttacatattaaaa aatgtaaaactgatttatatggtagataaccctacagttcagggctagaactttagatta aatgcattcataccctggcagatgtggtagcttgcctccaagatggcacccaatgaatga tccctgtaccaggattggtctatgtgaccaaaagcatacagcattagtgatgatacttat atcacttgggtaattacattataaaagatgtccatcatgg >IGR2260a tggtagataaccctacagttcagggctagaactttagattaaatgcattcataccctggc agatgtggtagcttgcctccaagatggcacccaatgaatgatccctgtaccaggattggt ctatgtgaccaaaagcatacagcattagtgatgatacttatatcacttgggtaattacat tataaaagatgtccatcatgggtgttcttttccctttctcttgctcagagacaagcaagc tgtcatgttataagcagccctttgaggggtccatgtgatgtcaaggaatgaagtctctag ccaacatttaatgaggaactgaggcccaccaacaaccttgagtgagcttggaagtagctc cttcagcatcagttgggtgtcgagatgactactgacagcttgactgcaacttcatgagag tcttctggaccagaaccactcagttaagtggctcccagattcctgatcctcagaaactct gagaaataatgaatgttggttgttttaaaatggtaaattttgaggtattatgttatgtgg caatagatagctaatatataaattatttgaatcaaacaatacgttaaattaaagctcaga agaataaacatctgtaattccttaatttgttttcccttctattctacagaatagaatttt acagatgaaccttgtagttacttgtgcaataagagacagt >IGR2261a ttgttttaaaatggtaaattttgaggtattatgttatgtggcaatagatagctaatatat aaattatttgaatcaaacaatacgttaaattaaagctcagaagaataaacatctgtaatt ccttaatttgttttcccttctattctacagaatagaattttacagatgaaccttgtagtt acttgtgcaataagagacagtatgttgtattgattaagtgcagagcctctggatgtatga tagaagaaagaccaatattcaattgctttcttcttcaattccaagcttgtgagcttgagc aaattttaaaagtgttttaagcctcagtttcctgggatggtagtgcttagctcgagctcc tagcatatattaactacaaactaaatattagctataattattagttttactttgattatt gactctaaataaataccttaagaactttgtgttctccacagatttggatatgtctggacg ttatgtaggctggagtagtcagcaattacttgcctgaggaagggaaggcctcctccttta agaaaagaataggctgggtgcggtggctcatacttgtaatcccagcattttgggaggctg aggagggtggatcacctgaggtcaggagtttgagaccagcctaaggaacatggtgaaacc ctgtctctactaaaaatacaaaaattagccaattgtggca >IGR2262a cagcaattacttgcctgaggaagggaaggcctcctcctttaagaaaagaataggctgggt gcggtggctcatacttgtaatcccagcattttgggaggctgaggagggtggatcacctga ggtcaggagtttgagaccagcctaaggaacatggtgaaaccctgtctctactaaaaatac aaaaattagccaattgtggcacgcgcctgtagtcccggctactcaggaggctgaggtgag aggattgcctgagcctgggaggtggaggttgcagtgagccgagatcgcgccactgcactc cagcctgggcaacagagtaagactccgtctcaaaaaaaaaaaaaagaaagaaagaaaaga gtagaaggcccaagcttagtccaatattatagcttcagcatcagagtagagaatgattca gagcatctgtccagtgtctgctgtagatccctcaaatccgtgtttggacgcttctggtaa ggggtgtatggcagatgcacccgacagatgcacttggcagcaataacttatgcatacctg aagaatgaccctatggtctaagaagaatgtgtgttcagagctccaagctaaggaatctgg gagtggccaacccagatatttcatttcttatctatgacgaacttctgaactgctcccacc cccagcccatcctgtagaatgcaggccctacgaggcgatc >IGR2263a cccgacagatgcacttggcagcaataacttatgcatacctgaagaatgaccctatggtct aagaagaatgtgtgttcagagctccaagctaaggaatctgggagtggccaacccagatat ttcatttcttatctatgacgaacttctgaactgctcccacccccagcccatcctgtagaa tgcaggccctacgaggcgatcaaagccctttgttttaggttaaatgaaggttgcctggtg gaggttgctaggggaaaggtgttaagtaaaaatgttatataaactgcatggtgttttttg tttgtttttgtttttttgagacagagtttttgctcttgttgcccaggctggagtgcaatg gtgcaatctcggctcactgcaacctccgcctcctgggttcaagtgattctgctgtctcag cctcccaagtagctgggattacaggtgcccaccaccaggcccggctaattttttgtattt agtagagtcagggtttccccatgttggtcagcctggtctcaaactcctgacttcaggtga tccacctgcctcagcctcccaaagcgctgggattacaggtatgagccaccacgcctggcc aattgcatgctttttacaaggagttttggttctcctgcccagcccactgccactggactg ccctgtattgtaagtcccctcaataaaccttatgtctcag >IGR2264a catgttggtcagcctggtctcaaactcctgacttcaggtgatccacctgcctcagcctcc caaagcgctgggattacaggtatgagccaccacgcctggccaattgcatgctttttacaa ggagttttggttctcctgcccagcccactgccactggactgccctgtattgtaagtcccc tcaataaaccttatgtctcagtttctggttctaggtctcttcttcagcctcttgaacatg gtgccatccctactgaagtcaatggggtctgacatgactaggggaacttgaacaaaatct gaaatagctgtttttttgttgccaaaatcactgtaagacattatttgcctcagccccaga acattgaattatatgacccaagagtggagaaacagagaagtctgtctgtgtcatcagaca atatcccaagtgggatgtcatcaccccaatgcatattggcatttgggcagagtagagcag cgtcagcctagcaagacttggcacaattctgttggattgcacaatagaatgagaaatcac atttctgctgttatgtgattctgcattttaactccagtttgtttggcctggacagacagg taactagccatgaagacaatggaccttgaaacattctgaagactagaaaaagtatgtaat aaaatactttgaacaactgtttaaggacttaaatgtccag >IGR2265a ggcacaattctgttggattgcacaatagaatgagaaatcacatttctgctgttatgtgat tctgcattttaactccagtttgtttggcctggacagacaggtaactagccatgaagacaa tggaccttgaaacattctgaagactagaaaaagtatgtaataaaatactttgaacaactg tttaaggacttaaatgtccagactgtttctttagatgagtgtaatttccaatgtgaaacc ccacaattcggcttcaagaggtacaggacagtttttgaattccacagaaaaaattttgca ttgcaacaaacttgaccatcctatttgtggtagtagaaatgtaaattcattcccctcaga gatacctgcaaaaatgaaatgtgaaatattctgcttgcattttaaagactggttattgca ttctagaatagatggaaaagacattagtgagggccaatatagaaatatgagttttcccaa aagacttttatgtatatatatgacatggcaggaaaattgggtcactagtggtttttactt cttcgttcatttggcaaacatatgaatagactgatgtgtgccaaacactgttccgagttc tgggaactgaggaaagaaacaagctatctgttttcatggagctcgtattttacttggagg atggagaggctgacaataaacttgtacaaataaatacaaa >IGR2266a atgacatggcaggaaaattgggtcactagtggtrittacttcttcgttcatttggcaaac atatgaatagactgatgtgtgccaaacactgttccgagttctgggaactgaggaaagaaa caagctatctgttttcatggagctcgtattttacttggaggatggagaggctgacaataa acttgtacaaataaatacaaacttcaagtagtggtaattgccaaggtgaaagaaaagaga gtaatggtatagaatgacagtcattgggtagctgctttagatgaatggtaagtgaacatg tttctgagaaagtgatatctgagctgagaggcaaaggacgagaaggaatctgtcatgtga agatctgggaagcaggtgtactaagcagaagagcagcaagtacaaagactgtgaggtaag ggatgtgctcggggtgactaagtaacggagagaagaccagcgtgactagaacatagtgat caaagtgagtaatgttggaacataagtcagagacattggcaggaggccagtttttatgga agccaaattgtctagtgccttgtagatagtggcaaggagtttggattttattctagatgg aacactaccagaatattttttcttttttgagacagggtctcactgtcacccaggctggag tgcagtggcatgatcttgactctctgcaacttctgcctcc >IGR2267a acataagtcagagacattggcaggaggccagtttttatggaagccaaattgtctagtgcc ttgtagatagtggcaaggagtttggattttattctagatggaacactaccagaatatttt ttcttttttgagacagggtctcactgtcacccaggctggagtgcagtggcatgatcttga ctctctgcaacttctgcctcctgggcttaagtgatcctcacacctcatcttccccagaag ctaggactacacgcaccacacctggctaatttttgtattttttgtagagatgggattttg ccatgttgcccaggctggtcttgaatgctgcccactttggcctcccaaagtgctaggatt ataggtgtgggccaccgtgcctggcctatcagagtattttcaggcagagaaaagcataag gtcttacttctagcataaaaggaacattctggctgctatatagagaagggactgtagagg acaagaatgaaagcaggttgactgattagaaagcattgcagcattataggcaagagctta tgatggcctgaactagagtggtaactgtggaagagataaatggatgaattcagaatattt ttggaggaaaaaggtgacatgatttactattggatgtgggcatgagggaaggaaattaag gatgactcctggatttttagcctgagcaactttatagctt >IGR2268a gactgattagaaagcattgcagcattataggcaagagcttatgatggcctgaactagagt ggtaactgtggaagagataaatggatgaattcagaatatttttggaggaaaaaggtgaca tgatttactattggatgtgggcatgagggaaggaaattaaggatgactcctggattttta gcctgagcaactttatagcttttcatgtttgtttttgaaatggggagatttgatggggtg ggggtttgggaaattaagagttttttatttttattttttgctttttaaaaattgtggtga aatacacataacataaaatttaccattttaaccactcttaagggcattaagtacattcac attgtgcaaccatcaccatcatccatctgtagagaactcttttcatcttgcaaaattgaa actctgtacctattaaacactaactccccactcccctccttaccctagccccgaaaaccc ttctataatacagaagtctctatgaatttgaccactctcataagtggaatcacatagtat ttgtccttttgtgactcgcttttattgtcacttagcataatgtcttcaaggttcatccat gttgtagcatatgtcagaatttccttcctttttaagactgaataatatgccattatatat gtatactacattttgtttacccattcatccactgatggac >IGR2269a ctatgaatttgaccactctcataagtggaatcacatagtatttgtccttttgtgactcgc ttttattgtcacttagcataatgtcttcaaggttcatccatgttgtagcatatgtcagaa tttccttcctttttaagactgaataatatgccattatatatgtatactacattttgttta cccattcatccactgatggacacttgggttgcttccatcttttgcctgttgtgactaatg ctgctgtgaacatgtatgtacaagtatctatttgagtacttgcttttaattctttgggta tatacccagaagtggaattgctggatcatgtggtaattctatgtttaatttttttaagga attgccatactgttttccccggtagctgtaccattttacattcccaccaacagtgcacaa gagttccagtttctccacgtcctcgccaatacttgttattttctgtggttttgctgttgt tgttgttttgtttgtttttgtttttttacagaagctatcctaatgggtataaagtggtat ttcattgtggttttatttgcatttccctaattattaattatgttgagcatcttttcatgt gcttattggcaatttatatattttctttggagaaatgtctactcaactcttttgcccatt ttaaaatcaggttttttttttgttgttgttgaattgtagg >IGR2270a gtttttttacagaagctatcctaatgggtataaagtggtatttcattgtggttttatttg catttccctaattattaattatgttgagcatcttttcatgtgcttattggcaatttatat attttctttggagaaatgtctactcaactcttttgcccattttaaaatcaggtttttttt ttgttgttgttgaattgtaggagttctttacatatttgggatatgaaccacttatcagat acatgatttgcaaatattttctcccattctatgccttttcactattgattatatcctttt acgcacagaagttttacatttttgatgtagcccaatttttctattttttcttttgttgcc tgtgcaagagttttattttaaatgcaattttgggatgtctattagacatccaagtcaaaa tgtcaaatagacggctggatatatgagtctgaaggtcataaaagagatcagaatgagata taaattagggaatcattcacatatagatggtatttaaggccatgggtctggacagaatca cccaggagagaagtcatataggaacacataggtttccctagggaatacagtcatcttaga gtaaaattccatcgaaggagatcaggaggtcttggctgagttaaatttggataatataag ttattaactatgttaatgtgttctaagctagatgccaggt >IGR2271 a catatagatggtatttaaggccatgggtctggacagaatcacccaggagagaagtcatat aggaacacataggtttccctagggaatacagtcatcttagagtaaaattccatcgaagga gatcaggaggtcttggctgagttaaatttggataatataagttattaactatgttaatgt gttctaagctagatgccaggttaaggcagaaattaggaggtcctgggcaagtatcaattt gctctgctattgtattattacaagaataatactaacaatagtacatgacctcatttcatc ctcacaatagctttacgcgattgatattcttgtcttcactttacaggcaaagaaacaaaa gagaagtaaagtaatttacccagttgctatagttagcatgtggtaggtccatattagagg tctggtctgtctgcatgatggttaattttatgagatagcaagtaaaacattatttgtgtc tgtgtctgtgtctgtgaggatgtgttcggagaggttcacaagcatttgaatcagtagacg gagcaaataaggtccgccctcaccaatgtgggcaggcatcatccaattcactgaggactc ctgctcacacagaacaaaaagtcagaggatgtgcctatagttccagcttcttggaaggct gcggcaggaagatgctggggcccaggagtttgaggccagc >IGR2272a atgtgttcggagaggttcacaagcatttgaatcagtagacggagcaaataaggtccgccc tcaccaatgtgggcaggcatcatccaattcactgaggactcctgctcacacagaacaaaa , agtcagaggatgtgcctatagttccagcttcttggaaggctgcggcaggaagatgctggg gcccaggagtttgaggccagccagggcaacatagtaagacctttctctttaaaaaaattt tttttggctgggtgcagtggctcatgcctgtaatcccagcactttgggaggccgaggcag gcggatcatgaggtcaggagatcgagaccatcctggctaacatggtgaaaccccgtctct accaaaaatacaaaaaattagccgggcgttgtggtgggcacctgtagtacccgctactca ggaggctgaggcaggagaatggagtgaaccccggaggcggaggttgcaatgagtggagat tgcaccactgcactccagcctgggcgacagatcaagactccgtctcaaaaaaaaaaaaat ttttttttaaggcataggaagggcaaattctctcattctctctcttcttgagctgggaca tccattttctcctgccttcaggaaatcagagctccatgttcttggatctcccgactctgg gacttacaccttacccttttcccctcagtctttcagactt >IGR2273a ctgggcgacagatcaagactccgtctcaaaaaaaaaaaaatttttttttaaggcatagga agggcaaattctctcattctctctcttcttgagctgggacatccattttctcctgccttc aggaaatcagagctccatgttcttggatctcccgactctgggacttacaccttacccttt tcccctcagtctttcagacttggactgaattacaccatcacctttcctggttctccagct tgcagatagcatgtcatgggacttcttagcctctgtaatcatatgagccagttcatatag taaatctcctcctattgatctatacctatatctgtaatcctattagttgggtttctttgg aaaactctaatacccccttatccacagtttttttttttttctgcagtttcagttatctac ggccaactgggtaaaccaaataggtgagtacagtacaataaaatattttgagagagagat gcacatttgcatgacttctattacagcatattgttataatcattctattttattagctat tgttagtctcttattctgcataatttataaattaaattttatcttaggtacgtatgtatg tatgtataggaaaaaacctagtatatatagtgttcagtactatctgaggtttcaggaatc ccctggtgttcttggattgtagccccctgccttcaagcct >IGR2274a attacagcatattgttataatcattctattttattagctattgttagtctcttattctgc ataatttataaattaaattttatcttaggtacgtatgtatgtatgtataggaaaaaacct agtatatatagtgttcagtactatctgaggtttcaggaatcccctggtgttcttggattg tagccccctgccttcaagcctgcactctcaattactgatgctacatctcattaccctgaa agatgaaatctagccttgagcccttaccaactggctgcattagatcattttagatctcca tgtcaccgcagtcacatttgtgtgtggtgaatggtccaggagagatggtgctattcctgc caccttcattagcctggcttgcattctcttctgaacacttgggtcttattaacactgtgc caggttctcatataccccaaataaagaaaaagaaagtagatggatacagtgtacatacta ggcccaacagaagttatgcttttactccctttcctcttcaatttagatactactatggcc ctttgcttccgtctatctcagttccttcgttgtcttatcattccattcacctctactgca aggccctaaatccaaccatttggtcactgtactcctaccctgggtcactggaggaaatca cacaaccatgtgagttggtgtcttgacacatttacatttc >IGR2275 a ttttactccctttcctcttcaatttagatactactatggccctttgcttccgtctatctc agttccttcgttgtcttatcattccattcacctctactgcaaggccctaaatccaaccat ttggtcactgtactcctaccctgggtcactggaggaaatcacacaaccatgtgagttggt gtcttgacacatttacatttccaatcacaattggaccctcagcccacttgttactctctc aacccatgtttccttgcacccatcaacagccccccttctttcttgtatcttaagtcagca tcctggattgagagtgaagagtaaaatggtttgacttattgtgagcttagcctttgcaag actagtaaacaaaaggactggggtagtggcaagagtatgaatgggctggagggatcacaa ggtataaactgaaagggaaaggaaatgatatcaggtgagagctgaagagttgggaggaaa acaaaggtcctagagtgagatggagctgttgtgactgatgagaggcccagggtgtgtcct cagcagcaagagtgtgaagtataggtgaaggtcaagtactgcgaggctaaggtgtagcac tactcatcttcctgagcacaaaagtcaccagcaccttgggctgggtgtcagagagctcac agaatgtggataaccaaccaggcagatgttggtaacagca >IGR2276a atggagctgttgtgactgatgagaggcccagggtgtgtcctcagcagcaagagtgtgaag tataggtgaaggtcaagtactgcgaggctaaggtgtagcactactcatcttcctgagcac aaaagtcaccagcaccttgggctgggtgtcagagagctcacagaatgtggataaccaacc aggcagatgttggtaacagcaaccaggagggcacagcacaaacctgagcaggtcttttat gtatgtgaaggtgaaggagttatgatttagaaatggcagtgggaagcaaggagaatgctg agagcctgctcagctcttgtcttccaggatcatggatagtgcaaaatgagtagccttcct ttgagagacagagccatgaggctagtggagtgctcagaaagaagccagatctctatcaag gaaaggagatggagagaacaaccagggatgtacttgaaagaggagagttgcatgtctaca atggaatatgtgttgcagaggactcagtcacagagaagacaactgcaggagggtgagctg gagggctctgcaggggcaggagcacagtagggcattagaatgggagttttagatgagaag gattacatttgcagtgctggaggaagatcatctcaaggttcacaaaatcaagctttaaac ttgtctgtgtcaacagacggaggcattgggtgatagttca >IGR2277a ggactcagtcacagagaagacaactgcaggagggtgagctggagggctctgcaggggcag gagcacagtagggcattagaatgggagttttagatgagaaggattacatttgcagtgctg gaggaagatcatctcaaggttcacaaaatcaagctttaaacttgtctgtgtcaacagacg gaggcattgggtgatagttcaaatccccataattttttataatcctttcagcagtctgtt aaatataaccttggtgataagctaagttacctcagcatagcaagcttggcttggtctaaa tcagggtagaggtgattgctgctcaaaggaagtgagagagacacccagctctggattgga gaacatgactttgacctgggtttcagcctccacagggctaagccccaggggagcactggg caagttgctaaggccacaagcaggagtttataaccaggctagactaagcccactgatgca agaattttttttttttttttttgagacagagtctcactctgtcacccgggctagagtgca gtggtgtgatcttggctcactgcaacctccgcttccctggttcaagtgattctcctgcct cagcctctcaagtagctgggattacaggcacccgctaccatgcctggctaaattttgtat ttttttagtagagacagggtttcaccgtgttggccaggat >IGR2278a tttgagacagagtctcactctgtcacccgggctagagtgcagtggtgtgatcttggctca ctgcaacctccgcttccctggttcaagtgattctcctgcctcagcctctcaagtagctgg gattacaggcacccgctaccatgcctggctaaattttgtatttttttagtagagacaggg tttcaccgtgttggccaggatggtcttgagctcctgacctcaagtgatccacctgccttg gcctcccaaagggctgggattactggcttgagccaccatgcccagcctgatgcatgaatt tgcattcttcatgctcttcatctatgcttctgaagacctggcacttagtcaacactcagt aagtttttattttttaactgctttatgattataaaagtaatatatgaagcatttgtaaag tatggaaatctggaaaaaataaaacagaagtcatctataatctgaccatccaaacatacc tactgttaataccttagtctacgttctttctttttttcctttttttgagatggagtcttg ctgtgttgcccaggctggagtacaatggcatgatttcggctcactgcaacctctgcctcc caggttcaagcagttctcctgcctcagcctcccaagtagctgggcttacaggcatccacc accatgccctggtaatttttgtatttttagtagagatggg >IGR2279a tacgttctttctttttttcctttttttgagatggagtcttgctgtgttgcccaggctgga gtacaatggcatgatttcggctcactgcaacctctgcctcccaggttcaagcagttctcc tgcctcagcctcccaagtagctgggcttacaggcatccaccaccatgccctggtaatttt tgtatttttagtagagatggggtttcgccatgttggccaggctggtctcaaactcctgac ctcatgtgatctgcccgcctcagccttccaaagtgctaggattacaggtgtgagccaatg cgcctggcctttttttttttttaagacagttttgctctttttgcccaggctgtagtgcag tggtgtgatcttggctcactgcaaccaggttcaagtgattttcctgcctcagccttctga gtagctgggactacagacgccaccatgcccagctaatttttttgtatttttagtagagat gggggtttcaccatattggccaggttggtctccaactcctgactttgggtgatccgccca cgttggcctcccaaagtgttgggattacaggcatgaaccactgtgcccagctgagcctac tttcttctggtctttttctcatgcctccccaccaccaccccagccccccgccattacata cgtatatatgtttattttttttttaaagagatgaagtctt >IGR2280a ccaggttggtctccaactcctgactttgggtgatccgcccacgttggcctcccaaagtgt tgggattacaggcatgaaccactgtgcccagctgagcctactttcttctggtctttttct catgcctccccaccaccaccccagccccccgccattacatacgtatatatgtttattttt tttttaaagagatgaagtcttgctctgttgcccaggctggtaggctgatctcaaactcct ggcttcaggtgatcctcctgtgttggcctcccaaagtgctgttgttacaggcataagcca tcacacctggctatttttcacgctttaaaaactcactttattcattcatttattcactca ttctttgattaacactcatatactggttttattttattattttatatttttagctacagg gtctcactctgtgcccgaggctggagtgcagtggcatgatcatgactctgcaaccccgaa ctcctgggctcaagggatcctcccaactcagcctcccaagaagttaggattacaggcaca tgctaccacaccctgctaatttttttaaattaatttttttcttccttttttttttttttt tttttttgtagaaccagtgtgtgttaggccattcttgcattactataaagaaatacctga gactgggtaatttattaagaaaagaggtttaattgactca >IGR22 81 a ctcccaactcagcctcccaagaagttaggattacaggcacatgctaccacaccctgctaa tttttttaaattaatttttttcttccttttttttttttttttttttttgtagaaccagtg tgtgttaggccattcttgcattactataaagaaatacctgagactgggtaatttattaag aaaagaggtttaattgactcacgatttcacaggctgtataggaagtgtggcactaggcat ctgctcagcttctagggaggcctcagggagcttttactcacagtggaaggtgaaggggga gcaggtgtgtcacatggtaaagacaggagcaaggtggggggaggtgccacacccttaaac aaccagatttctcaagaactcacttattatggtggggacagctccaagccatgagggatc tgcccccatgaccaaaacacctcccagcaggccccacctccaacattagagattacattt ccacatgcgatttggacagggataaatatccagactatgtcattttgcccctggccctcc taaatctcatgtccttctcaagttgcaaaatacaatcatgccttcccaagagttccccaa agtcttaactcattccaatgttaactccaaagcccaaaattcaaagtctcatctgagaca aggcaagtctcttccacctatgagcctataaaatcaaaaa >IGR22 82 a ggataaatatccagactatgtcattttgcccctggccctcctaaatctcatgtccttctc aagttgcaaaatacaatcatgccttcccaagagttccccaaagtcttaactcattccaat gttaactccaaagcccaaaattcaaagtctcatctgagacaaggcaagtctcttccacct atgagcctataaaatcaaaaacaagctatatacttccaagttacaatgggtgtataggca ttgggtaaacatgcccattccaaaagagaaattggccaaaagaaaggggctacaagctcc atgcaaattcaaaacccagcagggcaattattaaattgtaaagctccaaagtaatcttct ttgactccgtgtcccatatccagggctcactggtgcaagaagtgggctcgcaaggccttg ggaagcttcgcccctgtagtttgcatagtacagcctccacagctgctcttatgggctaga gttgagtgcctgtggcttttccaggcacagggtgcaagctgccagtggatctaccattct caggtctggagggtggtgacccctttctcacagctccaccaggcagttccccagtggaga ctgtgtggggccttcaaccccacatttcccctccaaactgccctagtaggggttctctgt gagggttccacccctacagcaggcttctgcctgggtaccc >IGR2283a tccaggcacagggtgcaagctgccagtggatctaccattctcaggtctggagggtggtga cccctttctcacagctccaccaggcagttccccagtggagactgtgtggggccttcaacc ccacatttcccctccaaactgccctagtaggggttctctgtgagggttccacccctacag caggcttctgcctgggtaccctggctttcttgtacatcctctgaaatctaggtagaggct gccaagcctccttcactcttacagtctgcatgcctgcatgcttaacaccacatggaagct gccaaagcatatggcttttgctctttggagcagcagcctgagctgtacctgaggcccctt gagccacagctggagctggaacagcctggatgtagggagcactgtcctaaggaggctgtg cagagccatggggtcctaggcctagcccatgaaatgattcttcctcctaggtctctgggc ctgtgcctgtgatggcaagggctgcccctgagatctctgaaatgccttcaaggccttttt cccattgtcttagctattagtacctggctctcttttagttattcaaatttctctagcaag tggttgctccacagcctgcttgaattcctctactgaaaatgcttctgctttctctatcac atggccaggctgcaaattttctaaagttttacactctgct >IGR2284a ggctgcccctgagatctctgaaatgccttcaaggcctttttcccattgtcttagctatta gtacctggctctcttttagttattcaaatttctctagcaagtggttgctccacagcctgc ttgaattcctctactgaaaatgcttctgctttctctatcacatggccaggctgcaaattt tctaaagttttacactctgcttcccctttaaatataacttctaactttaagtcatttttt ttgctctcacatctgagttaagctgttagatgcagccatgtaacttcttgaacactttgc tgcttagaaatttcctctgccagataccctagttgtcactctgaagttcaaacttccaca gatccttacagcatgaacaaagtgcagccaagttctttgctaggccataatgagggtggc ctttgctccatttctaggttcctcatttccatctgagacctcatcagccacgccttcact ttccatatcaccatcagcattctggttacaaccatttgaccagccaagtactattctaac ttctgagaatacagaagtgctcctcatggaacttacagtctagtggaggaagaaggacaa taaatgcaacaaagaagtaaattagtcaggatgtcagagagtgataagtcccatggagaa aaatgaagcaggagaaaaatgaagcagggatgcataaagt >IGR2285a ttctggttacaaccatttgaccagccaagtactattctaacttctgagaatacagaagtg ctcctcatggaacttacagtctagtggaggaagaaggacaataaatgcaacaaagaagta aattagtcaggatgtcagagagtgataagtcccatggagaaaaatgaagcaggagaaaaa tgaagcagggatgcataaagttagttcagagagagaacaggatacaattttaaatagtgt ggtcagataagggtttattaaggaggtggcatttgggccaagacactaaggaagtaagag aacaagctatgtagatagctgggaagagcattcctaggaagagggaacaagtatctaata gagaagcatgtctagtatgttcaaagaatagcaaagccttggtagccttaatgaagaaag caatggagagagtaataagagatgatgtcagcgagctaaaggagggcatgaagattagag tagggccctataaactggatgaccactgtcaaatgaaattaaggctgttgaggcagaaat gatttgataaaagtttattggaagccaaatgtgaggatgaacccaggaaaacacaccaac aaagttgagagtgttctggagtctgttacaagttggaaagttagaagacaggagggggac tcttcatacaggagttgtcctttttcactggagggtacaa >IGR2286a tgaccactgtcaaatgaaattaaggctgttgaggcagaaatgatttgataaaagtttatt ggaagccaaatgtgaggatgaacccaggaaaacacaccaacaaagttgagagtgttctgg agtctgttacaagttggaaagttagaagacaggagggggactcttcatacaggagttgtc ctttttcactggagggtacaatacaaaggttacaataattggctacagattgcaacatgc agactaacatgtctacatgcaagacaatcagtaaaatgttatgactcagaaataaatcag tgtccttttcagtgtcagtaggtggtgcattgatcagtacatcaacaatttgaggaactt ctaagattccttactcaggacaaggtatcgccatgaatcacaagaccttcccaagatggg ttaatttggaagctgtttacttttaaagtaaactgtcaaatgtgacctgtaggttattgc catatataatttgtcatccaaattaggagacttctagaatgaaagttggaggtgagggtt attaatcattaacactagggctggttgccgtggctcacgcttgtaatcccagtactttgg gaggctgaggcaggcagatcacgaggtcaggggattgagaccatcctggccaacatggtg aaaccccgttctctactaaaaaatacaaaaaaaaaaaaaa >IGR2287a aaattaggagacttctagaatgaaagttggaggtgagggttattaatcattaacactagg gctggttgccgtggctcacgcttgtaatcccagtactttgggaggctgaggcaggcagat cacgaggtcaggggattgagaccatcctggccaacatggtgaaaccccgttctctactaa aaaatacaaaaaaaaaaaaaatttagctgggcatggtggcacatgcctgtaatcccagct actcagaaggctgaggcaggagaattgcttgaaccagggagtcggaggttgcagtgagct gagatcatgccactgcactccagcctggcaacagagcgagactccgtctcaaaaaaaaaa aaaaaaaaagttaacactagttcagtggagagaagccaggactgtgctggacaaactctg acgtgtaatcattctacttatagaccattgtaaggacttgggctttcaaaaaatctgact gagatgggaagcgattggaaggttttgagcagaaaagtaacatgatgtgattgagatatc cctgactactatgctgagagtagattgaaggggcgtaggagcagccttaatgaagaagga ttggctgggggctaacagaatgcagggaagaaactggattctgcatatgttgaaattatg gcaaaagattttattgacagattggatgtggagtacaaga >IGR2288a aggttttgagcagaaaagtaacatgatgtgattgagatatccctgactactatgctgaga gtagattgaaggggcgtaggagcagccttaatgaagaaggattggctgggggctaacaga atgcagggaagaaactggattctgcatatgttgaaattatggcaaaagattttattgaca gattggatgtggagtacaagaggaagagcagccaggaaaataaagtttccatttactgag ttggggaggacttcaggaagagcagatttgggatgaaattaggagcacatgttaaatttg acatgttatgtttgagacacctattatatatccaagtgaggatatcaagtgggcagttat tatgtgagcctggagttcactctctctatgtgttggtggtcatcagtgcagagatgatat ttaaatcatgagactggattttttaaaaaggaagaggactgaagactaagttctgggcac tccaattttgggcagtagcggagatgaagaaaaaccagcacactagatggtaaaggagca gccaacaaggtaagaggaaaaccaagcaagtgtcatttttgttgatttttttgatacaga gtctcactctgtcactcaggctggagtgcaatgacacaatctcggctcactataacctct gccttctgggtccaagtgtttttcttgcctcagcttccca >IGR2289a ggagatgaagaaaaaccagcacactagatggtaaaggagcagccaacaaggtaagaggaa aaccaagcaagtgtcatttttgttgatttttttgatacagagtctcactctgtcactcag gctggagtgcaatgacacaatctcggctcactataacctctgccttctgggtccaagtgt ttttcttgcctcagcttcccaagtagctgggactgcaggtgtgtgccaccacgcctggcg caagtgtcatgtagaaagcagttcaaggatgaaagagaaatgagtttgtcaaatgccttg agaggtcaggtaagatgatgactgtgaattgactattgaattcagaaacatgcaggtcac tgcggaccttgatagaggtgctctggtgaaaggtgagggctaaagcttaattgtagtggg gccaagtgaaaattggaagaacaaagttgaaagtagcaagtagatatagcaatcttccaa ggagtttcactgctaagggacagggagaaatggggcaggagctgacagcagaaactgggt caagagagagcttttacagcctctttgcatactgaatgggaaagatccagtagagaggga aaagatttatgatgggggagtcaggagaattgctagagcaacatgtgctcctaatttcat cccaaatctgctcttcctgaagtcctccccaactcagtaa >IGR2290a acagggagaaatggggcaggagctgacagcagaaactgggtcaagagagagctritacag cctctttgcatactgaatgggaaagatccagtagagagggaaaagatttatgatggggga gtcaggagaattgctagagcaacatgtgctcctaatttcatcccaaatctgctcttcctg aagtcctccccaactcagtaaatggaaactttattttcctggctgctcttcctctcgtac tccacatccaatctgtcaataaagtcttttgccataatttcaacatatgtagaatccagt ttcttgcctgtattctgttagcccccagccaatccttcttcattaaggctgctcctacgc cccttcaatctactctcagcatagtagtcagggctatctcaattacatcatgttactttt ctgctgttggtaagggagtagggggtgggggaggggtaagaagtatataaggctggggcc gggcacagtggctcacacctataatcccagcactttgggaggctgaggcaggccaatcac ttgagcccaggagttcagtactagcctagccaacatggcaaaaccctgtctctactaaaa atacaaaaattagctgggtatggtggtgcatgcctgtaatcctagctacttcggaggctg aggcatgagaatcgtttgaacctgggaggcagaggttgca >IGR2291a tataatcccagcactttgggaggctgaggcaggccaatcacttgagcccaggagttcagt actagcctagccaacatggcaaaaccctgtctctactaaaaatacaaaaattagctgggt atggtggtgcatgcctgtaatcctagctacttcggaggctgaggcatgagaatcgtttga acctgggaggcagaggttgcagtgagccactgcactccagcggggaggagagaccattca ggagaaacgggagaaaagacagagggtgtgggtacagatggagttaggctggtggattat gctgcttgtagaggttctctccattgcttctattttctaggtgaaataggaagccaaggc acagctgagggtgatcatgggggaggaggtgatggagttctgaagagaaagaaggtcttc caggatagagaatgaaccagggcaattaggatcctcttgaagtcactgatggtcagttta aagtgaaaccagtcagatggaatatattttccatctacatttggctatgcaggtgctagc aagaagtaggagggaggttagatttaaccagctttatagtttcccacaaaagcaaggcag ataagaaaggggcaaggaagatgattatgatgattaagcatggaatttaagctggccaag aaggggtgtgaggacatgagtaagatgagagatagcaaaa >IGR2292a gaatatattttccatctacatttggctatgcaggtgctagcaagaagtaggagggaggtt agatttaaccagctttatagtttcccacaaaagcaaggcagataagaaaggggcaaggaa gatgattatgatgattaagcatggaatttaagctggccaagaaggggtgtgaggacatga gtaagatgagagatagcaaaaacgtggacatctttgccaggtatggagccaaacacagta tgcattgtctcatgtaatccccacccaaatggaattgttatcatccctctttacagatga agaagctgagttttagggaagactgtaacttgctcaaagtcacacagctgatagagaagt gacacacccagcatcaggtcctggaacacttgtctccaaaggctatgtacttagccctat ttgctttaactggagtattagtgggcattacaaaaattgatgcatatgtacaaaggatgg taattttgtccagtatgtttttgttaatacttttccaacttgagttaattttaagatttt ctgttgtacagaattctttaaaagtttatagtaaaatctatttatcttcaatttcctatt catcttaaaattaaatgtcacctatattttcttctagcttttgatttatttactcttggc tctattttatttacatttattacatttggctctttagttg >IGR2293a tttgttaatacttttccaacttgagttaattttaagattttctgttgtacagaattcttt aaaagtttatagtaaaatctatttatcttcaatttcctattcatcttaaaattaaatgtc acctatattttcttctagcttttgatttatttactcttggctctattttatttacattta ttacatttggctctttagttgatcaggaattaatttggtatgtggtttatggtgggatac tatttattcccccagtttttccatttttaccagttcttcagcttgtcgattgtcccagca ccagtcttcaacaatgtatcattttcttgataatttataattcatctttatcatatgtta caatttttcaacacttgggtctgtttctgtgatacctcttctatttcgttgattgattta tcttttgtgtgtgtgtctgtgtgtgtgtgtgtgtgtttgtgtgttttccaggaaacccag agtagtgtagtcattgtgtgtttttatatatgtaagagaacatttccccttatcaatgat ctttttcaaaaatttcttaaacatattacatatttcttttttcagatgctctttacaaat attttttaacttcttaaaatatctcattgaggattccgttccaagatggccaaataggaa cagctctggtctgcagctcccagtgtgatcgacgcagaag >IGR2294a gtttttatatatgtaagagaacatttccccttatcaatgatctttttcaaaaatttctta aacatattacatatttcttttttcagatgctctttacaaatattttttaacttcttaaaa tatctcattgaggattccgttccaagatggccaaataggaacagctctggtctgcagctc ccagtgtgatcgacgcagaagacggatgatttctgcatttccaactgaggtacctggttc atcttactaggactggttggacagtgggtgcagcccacggagggtgagccgaagcagggc agggcatcgcctcacctgggaagcgcaaggagtcaggggatttccttttcctagccaagg gaagccgtgacagatggtacctggaaaaacgggacactcctgcccaaatactgcgctttt ccaaagtcttagcaaatggcacaccaggagattatatcctgtgcctggctcgacagatcc tatgtccatggagccttgctcactgctagtgcaacagtctgagattgacctgcaaggcag caacctggcatggggaggggcatccgccattgctgaggcttgagtaggtaaataaagtgg ctgtggaagctcgaactgggtggagcccaccacagctcagcaaggctgactgcctctgta gtctccacctctggggcagggcatagctgaacaaaaagca >IGR2295a tcactgctagtgcaacagtctgagattgacctgcaaggcagcaacctggcatggggaggg gcatccgccattgctgaggcttgagtaggtaaataaagtggctgtggaagctcgaactgg gtggagcccaccacagctcagcaaggctgactgcctctgtagtctccacctctggggcag ggcatagctgaacaaaaagcagcagaaacttctgcagacttaaacatccctgtctgacag ctctgaagagagcagtggttctcccaggatggtgttttagcttggagaacagacagactg cctcctcaagtgggtccctgacccccatgtagcctaactgggagacacctcccagtagcc gactgacacctcatacaggcaggtgcccctctgggatgaagcttccagaggaaggatcac tcagcaatatttgctgttctgcaatatttgctgttctgcagcctctgatggtgataccca ggcaaacaggtctggagtagacctccagcaaactccaacagacctgcagctgagggacct cactggtagaaggaaaactaacaaacagaaagaaatagcatcaacatcaacaaaaaggac atccacaccaaaaccccatctgtaagttaccaacatcaaagaccaaaggtagataaaacc acaaagatggggagaaaccagagcagaaaagctgaaaatt >IGR2296a gacctccagcaaactccaacagacctgcagctgagggacctcactggtagaaggaaaact aacaaacagaaagaaatagcatcaacatcaacaaaaaggacatccacaccaaaaccccat ctgtaagttaccaacatcaaagaccaaaggtagataaaaccacaaagatggggagaaacc agagcagaaaagctgaaaattctaaaaaccagagcacctcttctcctccaaaggatcaca actccttgccagcaatggaacaaagctgggtggagaatgactttgacgagctgacagaag tggacttcagaaggtcagtaataataaacttctcccagctaaaggaggatgttctaaccc atcgcaaggaagctaaaaaccttgaaaatagattagacgaatggctaactagaataaaca gtgtagagaagaccttaaatgacctgatggagctgaaaaccatggcacgagaactttgtg acacatgcacaagcttcaatagccgattcgatcaagaaaggatatcagtgattgaagatc aaattaatgaaataactcaagaagattagagaaaaaagagtaaaagggaacgaacaaagc ctccaagaaatatgggactatgtgaaagaccaaatctacgtttgattggtgtacctgaaa atgacagggagaatggaaccaagttggaaaacactcctca >IGR2297a tagccgattcgatcaagaaaggatatcagtgattgaagatcaaattaatgaaataactca agaagattagagaaaaaagagtaaaagggaacgaacaaagcctccaagaaatatgggact atgtgaaagaccaaatctacgtttgattggtgtacctgaaaatgacagggagaatggaac caagttggaaaacactcctcaggatattatcaaggagaacttccccaacttagcaaagca ggccaacattcaaattcaggatatacagagaatgccacaaagatactcctcaagaagagc aaacccaagacacataattggcagattcaccaaggttgaaatgaaggaaaaaatgttaag cgcagccagagagaaaggtcgggttacgcacaaagggaagcccatcagactaacagcgga tctctcggcagaaaccctacaagcccgaagagagtgggggccaatattcaacattcttaa agaaaagaattttcaacccagaatttcatatccagccaaactaagcttcataagtgaaga ataaaatcctttccagacaagcaaatgctgagagattttgtcaccaccaggcctgcccta aaagagctcctgaaggaagcactaaacatggaaaggaaaaaccggtaccagccactgcaa aaatatgccaaattgtaaagaccatcgatgctatgaagaa >IGR2298a agaatttcatatccagccaaactaagcttcataagtgaagaataaaatcctttccagaca agcaaatgctgagagattttgtcaccaccaggcctgccctaaaagagctcctgaaggaag cactaaacatggaaaggaaaaaccggtaccagccactgcaaaaatatgccaaattgtaaa gaccatcgatgctatgaagaaactgcatgaactaacaagcaaaataaccagctaacatca taatgacaggatcaaattcacacataacaatattaaccttaaatgtaaatgggctaaatg ccccaattaaaagacacagactggcaaattggataaagagtcaagacccatccgtgtcct gtattcaggagacccatctcacgtgcagagacacacataggctcaaaataaagggatgga ggaagatctaccaagcaaatggaaagcagaaaaaagcaggggttgcaatcctagtctctg attaaacagactttaaaccaacaaagatcaaacgggacaaagaaggccattacataatgg taaagggatcaattcaacaagaagagctaactatcctaaatatatatgcacccaatacag gaacacccagattcataaaacaagtccttagagacctacaaagaaacttagactcccaca caataataatgggagactttaacaccccactgtcaatatt >IGR2299a aacaaagatcaaacgggacaaagaaggccattacataatggtaaagggatcaattcaaca agaagagctaactatcctaaatatatatgcacccaatacaggaacacccagattcataaa acaagtccttagagacctacaaagaaacttagactcccacacaataataatgggagactt taacaccccactgtcaatattagacagatcaatgagacagaaggttaacaaggatatcca ggacttgaactcagatctgcaccaagcagacttaatagacatctacagacctctccaccc caaatgaacagagtatacattcttctcagcaccacatcacacttattccaaaattgacca catagttggaagtaaagcactccttagcacatgtaaaggaacagaaatcacaacaaactg tgtctcagaccacagtgcaatcaaattagaactcaggattaagaaactcactcaaaactg cacaactgcatggaaactgaacaatctgctcctgaatgactactgggtaaataacgaaat gaaggcagaaataaagacgttctttgaaaacaatgagagcaaagacacaacgtgccagaa tctctggaacacacttaaagcacggtatatagggaaatttatagcactaaatacccacaa gagaaagcaggaaagatcaaaatcaacaccctaacatcat >IGR2300a aacaatctgctcctgaatgactactgggtaaataacgaaatgaaggcagaaataaagacg ttctttgaaaacaatgagagcaaagacacaacgtgccagaatctctggaacacacttaaa gcacggtatatagggaaatttatagcactaaatacccacaagagaaagcaggaaagatca aaatcaacaccctaacatcataattaaaagaactagagaagcaagagcaaacaaattcaa aagctagcagaaggcaagaaataactaagatcagagcagaactgaaagagatagagacac aaaaacttcaaaaaaatcaacgaatccaggagctcgttttttgaaaagatcaacaaaatt gatagactgttagcaagactaataaagaagaaaagagagaagaatcaaatcgatggtata aaaagtgataaaggggatgtcaccaccaatcccacagaaatacaaactaccatcagagaa tactataaacacctctacacaaataaactagaaaatctagaagaaatggataaattcctg gacacatacagcctcccaagactaaaccaggaagaagttgaatctctgattagaccaata acaggctctgaaattgaggcagtagttaatagcccaccaaccaaaaacagtccaggacca gacagattcacagccaaattctaccagaggtacagaggag >IGR2301a caaataaactagaaaatctagaagaaatggataaattcctggacacatacagcctcccaa gactaaaccaggaagaagttgaatctctgattagaccaataacaggctctgaaattgagg cagtagttaatagcccaccaaccaaaaacagtccaggaccagacagattcacagccaaat tctaccagaggtacagaggagctggtaccattctttctgaaactattcctagcaatagaa aagagggaatcctccctaattcattttatgaggccagcatcatcctgataccaaagcctg gcagagacacaacaaaaaaaagagaggccgggcgcggtggctcacgcctgtaatcccagc actttgggaggccgaggcgggtggatcatgaggtcaggagatcgagaccatcctggctaa caaggtgaaaccccgtctctactaaaaatacaaaaaaattagccgggcgcggtggcgggc gcctgtagtcccagctactcgggaggctgaggcaggagaatggcgtgaacccgggaagca gagcttgcagtgagccgagattgcgccactgcagtccgcagtccggcctgggcgacagag cgagactccgtctcaaaaaaaaaaaaaaaaagagaattttataccaatatccctgatgaa catcgatgcaaaaatcctcaataaaatactggcaaaccga >IGR2302a cgggaggctgaggcaggagaatggcgtgaacccgggaagcagagcttgcagtgagccgag attgcgccactgcagtccgcagtccggcctgggcgacagagcgagactccgtctcaaaaa aaaaaaaaaaaagagaattttataccaatatccctgatgaacatcgatgcaaaaatcctc aataaaatactggcaaaccgaatccagtagcacatcaaaaagcttctccaccacgatcaa gtgggcttcatccctgggatgcaaggctgtttcaacatatgcaaatcaataaacataatc catcacagaaacagaaccaatgacaaaaaccgcttgattatctcaatagatgcagaaaag gccgtcgacaaaattcaaaagcccttcatgctaaaaactctcaataaactaggtattgat agaacgtttctcaaaataataagagctatatatgacaaacccacagccaatatcatgtgg aatgggctaaagctgttgacctgatagatatgggttcaagaggacacagctgaatactgt gcttaggaaaagaacagtttcaaaggctttccagattgtcagatttgatgatatcctcct tggtgcacacctctcttggctatggggcacataaaccacctctaccaatctaactggttt gtgcagtttttctgattttgtatctaccggcaaaatatat >IGR23 03 a cctgatagatatgggttcaagaggacacagctgaatactgtgcttaggaaaagaacagtt tcaaaggctttccagattgtcagatttgatgatatcctccttggtgcacacctctcttgg ctatggggcacataaaccacctctaccaatctaactggtttgtgcagtttttctgatttt gtatctaccggcaaaatatatcttaagccatttttaggaaacaggaggtttagtcacgtg ctcaacaaaagcacaacaaatggggagcatttaatggtgtaagggctgtgaggtgtagct gctgaaactgtagctaggagctgccttgctgccttcttgcaggcagattggccagatgag ccaggctaaaatacaattaatatctaccattgtggtttaatatgaaatatggatacctgg tctttgtctcagttcttgtcatagagttccccaaacctttagaacttcctgagtggtagg aatatctcattagtgataatgagcccctttgattcgataactcctgagtttatgctaatg aggttacttaatgtggggccctagatattcttaggatggggctagttcccggaaagacca ggtcatttgaggattagagggttggaacttttagctctacccactgatctctgggtgggg aaggtgctggagatcaagctgcctaaaaactcttgaacaa >IGR2304a tgagcccctttgattcgataactcctgagtttatgctaatgaggttacttaatgtggggc cctagatattcttaggatggggctagttcccggaaagaccaggtcatttgaggattagag ggttggaacttttagctctacccactgatctctgggtggggaaggtgctggagatcaagc tgcctaaaaactcttgaacaacaagatttgaggagcttccagtaaatgcgtccacaagct gggagggcactgcaccccagtttcactgggacagaagctcttgcacttggaatctttcca gacctagcccttcatgctgcttcatctggctgttcatctgtatcctttataataaattgg caaatgtaaaggtttagctgaatttggtgagcctttctagaaaattaattgaacctaaga aggggtctgtggaaaccctggtttgtagttggtaggtcagaggtgcgtgtggcttggatg ttcgaatggcatctgaagagggacagagcacacaacctgtgggatctgacactatctccc cgcagatagggtcagagcttaattctattagagaacaccccattggtatctgctggagaa ttacttggtgtatgagaagccccccaccacatctggtcacagaagtattgtgggttgagt gtgacagtacagggtaaaaagtggtttgttttttcctcta >IGR2305a gggacagagcacacaacctgtgggatctgacactatctccccgcagatagggtcagagct taattctattagagaacaccccattggtatctgctggagaattacttggtgtatgagaag ccccccaccacatctggtcacagaagtattgtgggttgagtgtgacagtacagggtaaaa agtggtttgttttttcctctaacagtgatcactccctctcaaaggagtgtggaaggtttt ctggataggaatactgcatataatcatttggttcacttcagaaactactataattttgac tgtgctggttcacttccacatgtacaaacacacacacatacacacacattgttgtcacct aatatttgcgttaatacaatgatgttatttttatttggatagtatttgtatgattggaaa tgagtgttaatctttatatgtattttaccagtccttgactaacatgttttcaagacatct taccaatccatttcattgaattaatgagtaaggagactctctagaaatggttggtttgta aagcaaggacattatctggaagaatcatccagagtttactgtatgacgagcatttcttga tagcaaggttcattttggtgtcaatcgttacagtcagtccatttcagtgggaacaacgaa tttctccacagggtcttatttttctgtttttcacttcacc >IGR2306a attaatgagtaaggagactctctagaaatggttggtttgtaaagcaaggacattatctgg aagaatcatccagagtttactgtatgacgagcatttcttgatagcaaggttcattttggt gtcaatcgttacagtcagtccatttcagtgggaacaacgaatttctccacagggtcttat ttttctgtttttcacttcaccaaatggggtagatattttttcagaatgcagttattagaa ccttgggattttcttctgtctccattgagtctcttgtttttttcccagatctgaacctga aaataaaatagatgctaaggaaaattaaatattcaagactttcctcctcaaaatgctcca tccaaattgacattgaaaaatatttctccaatcaatgaacaagtaactatttgaactcta atgagaacctcatggtgtagatctaatattttatgcttttaaacatctgaggctactttc ttaattaagcatagaagccagaatttaaactctttcacagttttcccaagcaaaggatag agagggaggcatgaaattcttggcaattaaagttgatactgaagtagttctatcattaga agaaaacaacttatcaacaatgggcactttttgctataaatgttctgtcagggatcagaa ttaattcatatgcagagttacctttatcaaggccaggcac >IGR2307a agaatttaaactctttcacagttttcccaagcaaaggatagagagggaggcatgaaattc ttggcaattaaagttgatactgaagtagttctatcattagaagaaaacaacttatcaaca atgggcactttttgctataaatgttctgtcagggatcagaattaattcatatgcagagtt acctttatcaaggccaggcactgggaacactttatcttttataacctcaaaatagccgta tgaaatatcccatatagcagatgggaatactgaagcttagtgaatattaagtgatatgcc caaatttttgcagtagatttgggatttaaagccaggcagtgttactcgaaactctaaact tctcctaaataccactaatcttttaaatgtttgctgtggtgtcataaaaagatactggtc tttgtccctggctcctaacatagagatcctaaatctcttataatttctggagtgataggg agtgataaaagcttcttttgttctaatgaggcaacccttggctgggcccttagatagctt cagggtgggggctggtcaccagaagactaagcctggattagaagcctggaacctctgggg agaggagagaggctggggatagacttaataatccatcatgccaacatgactaaacctcca tgaaaacctctaaatgatggggtttggagaacttccgagt >IGR2308a gttctaatgaggcaacccttggctgggcccttagatagcttcagggtgggggctggtcac cagaagactaagcctggattagaagcctggaacctctggggagaggagagaggctgggga tagacttaataatccatcatgccaacatgactaaacctccatgaaaacctctaaatgatg gggtttggagaacttccgagttggtgaccacatccacatgccaggagggcagtgcacctt aactccgtagggacagaacctctgcactcaggacccttccagacctctctgtatgtacct cttcatctggctgttcatttgtatcctttgtaagaaaccgctagtggccagtgttctgag tgctgtgagtcattctagcaaataatcaaacccaaggaggggatttgttggaaccccaga cttggtagcaaagtcagagagaaatgtgggtaacctggggacctgacatttgtgagtggc aagtgaagcaaggcagtattgtgggactgagtctttacacctgtggagtctgatgctaaa tttaggtattgtcaaaattgaactgcattataggacactcaataggtgtcagaattggtt tgcgtcaagaagaaaaacccttgcgcaatctcataagccaaaaaaagatgttgaattgtt ttatttttgcatttccttattaatgtggacaaataacttt >IGR2309a tgtgggactgagtctttacacctgtggagtctgatgctaaatttaggtattgtcaaaatt gaactgcattataggacactcaataggtgtcagaattggtttgcgtcaagaagaaaaacc cttgcgcaatctcataagccaaaaaaagatgttgaattgttttatttttgcatttcctta ttaatgtggacaaataacttttttcatgtatatattggacactgaagtgacttcttctgt aaactgtctgttcttgtcctttgctggttttcctactgaattgtttgtctttttctcact ggttactatgagctttttgtatattaagtatattagccttatgtttaggttttgtgtagc aaatattttctcctggcttattgacttttgtctttgtgggtggtttctttttgccttgcc aataatttaaaaaatgtacaatcagatatatcaatctgttcctttatggttctttgattt tatgttatgctcagtaagatcttctctaaggttataaaaatgtttgtttcctcctggtat atttatgattttacatttttaggcctaaattttttaactgtctggattttatcttgatgt gttttttttttggagacggagtctcgctctgtcacgcagactggagtgtagtggcgcgat ttcggctcactgcaacatccaccaccctggttcaagcgat >IGR23 I Oa tcttctctaaggttataaaaatgtttgtttcctcctggtatatttatgattttacatttt taggcctaaattttttaactgtctggattttatcttgatgtgttttttttttggagacgg agtctcgctctgtcacgcagactggagtgtagtggcgcgatttcggctcactgcaacatc caccaccctggttcaagcgattctcctgcctcagcctcccgcgagctgggattacagggg tgcgccaccatgcctggctaatttttgtatttttagtagagatggggtttcaccatgttg gacagactgttctcgaactcctgacctcaagcaatctgcctgcctcaatctccctaagtg ctgggattacaggtgtgagccaccatgcccagccaatgcattttttaaagagacaacttt ttaatttattcaaaatgtctagctgaatgttctaataccttttactgaataactattccc ccttgactttgctactttttattacatactgaatttttatattttcttgggttttatcct gaactctatcctattccattggtttctattcctataccattatcacattgttttaattac tattgctcaacaatatgctttattactattattattatttttgagacagagtctagctct gttgcccagtctggagtgcggtggcatgatgttggctcac >IGR2311 a tattacatactgaatttttatattttcttgggttttatcctgaactctatcctattccat tggtttctattcctataccattatcacattgttttaattactattgctcaacaatatgct ttattactattattattatttttgagacagagtctagctctgttgcccagtctggagtgc ggtggcatgatgttggctcactgcaacctccacctcccgggttcaagcaattctcctacc tcagcctcctgagtagctgggactacaggtgtgtgccaccatgcccagctaatttttgta tttttagtagagacagggtttcaccatgttggccaggatggtctcgatctcttgacctca tgatccgcctgcctcagcctcccaaagtgttgggattacaggcatgtgccaccgcgcctg gcctattatttatttattttttttgagacggagttttgctcttgttgcccaggctggagt gcagtggtgtgatctcagctcactgcaacctctgcctcctgggtcaagcagttctcctgc ctcagcctcctgagtagctgggattacatgtgactgccaccacacccagctaattttttg tatttttagtaaagatgaggtttcacta >IGR 1 OOOa ggctctgactaaagaatatgacagatcagatattcctctccacctgctcccctcccccat ccctttttagagggctggggaaattttagtttttaatcaaaggctttatttctccagttg tgcaaaggaatttaactgggactttacaactgaataaagtatttctcagagtcgatacta atcttagcaagaggatattgcctaacccaacctaaaagcagcagagtcattacagaaata ttatgttggccttgatttctaccccaccatgagttatgctactcaccaggtagcctgttt tgtttttcatttttagagacagggtctcactctgtcacccaggttggagtgcagtgtcac aatcatagcttactatgacctcaaactcttaggctcaaatgatccacctcagcctcccaa gtagctgggaccacaggtgtctgccactacacttggctaattttttaattttttgtagag ataggagcttgctaagttgcccaggttggtttggaactcctggcttcaagcagtcctccc gccttgggctcccaaagtgctgaggttacaggcgtgagccactgtgcccagcatgtgccc tgttttaagtgtatctcctgctgtagtccgttacatgtgcacatctcttctgtgtttact gtgtacctgctctatgctgagaagaatgtcttttcaaaac >IGR1001a cccaggttggtttggaactcctggcttcaagcagtcctcccgccttgggctcccaaagtg ctgaggttacaggcgtgagccactgtgcccagcatgtgccctgttttaagtgtatctcct gctgtagtccgttacatgtgcacatctcttctgtgtttactgtgtacctgctctatgctg agaagaatgtcttttcaaaactcacaccctcccttaggagagagaggtggccacatgaat ggagaatgactgcatagcatgctgagggctgtggtaaaagaggctgaatggtgagctgcc aggtacggcatccttcctgtgcagctgacatggtgcctgacacatgtctgcctgaccaaa ggggcagaagaggcttctcaggggaagttctgtttgaggtcttcagcagttcaacagctg gggaaaggtattccaggagcgagtgagtttggatgccatgtgcgttggtggtgtgcttga agtagagcaaacggggtggaggcaaatgagcctgaaaaggaaagagatgggacaggatcc tactgtggaagagttttctgtaagcagtgggaagccacagaaggattttaagtgggccat tcacattgtgttttattttgagacagggtctcactgtcacccaggctggagtacagtggc atgatcaaggctcactgaagcctcaacctcccaggctaaa >IGR1002a aggcaaatgagcctgaaaaggaaagagatgggacaggatcctactgtggaagagttttct gtaagcagtgggaagccacagaaggattttaagtgggccattcacattgtgttttatttt gagacagggtctcactgtcacccaggctggagtacagtggcatgatcaaggctcactgaa gcctcaacctcccaggctaaagcaatcctcctgcttcaacctcccaattagctgagagca cagctgtgtaaaaatttaattttttttttttttgtagagacaggatgttggccaggctgg tctcgaacttttgggttcaagcgaagctcccatctcagtctcccaaagtgccgggattac aggcgtgagccactgcacctggcctatttgtgttttagaaaaacaactgctgggccgggt gtggtggctcacccctgtaatcccagcactttgggaggttgaggcaggtggatcacgagg tcaagagattgagaccatcctggccaacatggtgaaaccccgtctctactaaaaatacaa aaaaatttacctgggcgtggtggcatgcacctgtagtcccagctacttgggaggctgagg caggagaatcacttgaatcccgggggcggagattgcagggagccgagatcgcaccactgc actccagcctagtgacagagtgaaattctgtctcagaaaa >IGR1003a ctggccaacatggtgaaaccccgtctctactaaaaatacaaaaaaatttacctgggcgtg gtggcatgcacctgtagtcccagctacttgggaggctgaggcaggagaatcacttgaatc ccgggggcggagattgcagggagccgagatcgcaccactgcactccagcctagtgacaga gtgaaattctgtctcagaaaaacaaaacaaaacaaaaagaaacaactgctggagagtttg tgaaggattagagggagcaagacgggatgctggttgggatggtggttgggagagcagatg ctatacacacctgtgtcccggaggtggaaagggtcatcagccagaggagtaaccgccctc tcttctcagctgttttgcttgcactcgtgattggtataaactgagggagcaaatgtgtgt cctcttattcacgttgcctagtaagtacccaggtgtgcagtgagcatacaaaacatcaaa acatattttcgtttggctgaactctggctaatcagaaactagaaggaacagacagcttag agacttaaagttggactaggaagaagttgacaggatggattagaagatagccactttagg ctgggtacagtggctcatgcctgtaatcccagcactttgggaggccgaggtgggtggatc acctgaggtcaggagttcaagaccagcctggccaacacag >IGR1004a aactctggctaatcagaaactagaaggaacagacagcttagagacttaaagttggactag gaagaagttgacaggatggattagaagatagccactttaggctgggtacagtggctcatg cctgtaatcccagcactttgggaggccgaggtgggtggatcacctgaggtcaggagttca agaccagcctggccaacacagtgaaaccccatctctactaataatacaaaaaaatgaggc aggtgtggtggcaggcacctgtaatcccagctactcaggaggctgaggcaggagaatngc ttgaanctgggaggtggaggttgcagtgagccaagatcnngccantgcactcnagcctgg gngncagagcgagantctgtntnannaaaaaaaaaaaaaaaaaaaaaaaaannncaacac tttagagagccaaggagagggtgtctgggtacttagggcaaaagcccagttgaggaaacg ctgggcgtgacagctaactggggattttagtactccacctgggaatggaactcaaacttg agctaataaattgaatctagaaatcagccccaaggctagagaaagtgcctgccttgctcc tagtggaagctactagaaactgagaagccaaccctgtgtgtcataggccaggctgtgcct agctccataaggaagctctgcgttgtgcttagccttgaga >IGR 1005 a ggggattttagtactccacctgggaatggaactcaaacttgagctaataaattgaatcta gaaatcagccccaaggctagagaaagtgcctgccttgctcctagtggaagctactagaaa ctgagaagccaaccctgtgtgtcataggccaggctgtgcctagctccataaggaagctct gcgttgtgcttagccttgagattcccatccttagataatgtgggcaccctgagattatgt gaaggagggcagagaaaaaccaagagcagggtcaatgacatggacagcaacaagcagagc ccccttggcatttgtaacagaggtgaccctttgtaactgtagcccaacaatgtttccata aaagacagccatagatttgagccaaatcattttttgattcatttttccaataaataatta ttaccccctagatgccagttacagatagtttattcattggcaaaaggtggaggtatgata gccaggagggaaaggttcagacttactgtcaatgtcatattccacacacagacaaaaggc atgtcccatgaagcaggcacgggctgtggctgagtttgctacataaatgtgctcagatga caagcatcttaactttcacttaatcctgaaggtttttcaccctctgttttttgttttgtt tttttttttttgagacagaatctcgctctgccgcccaggc >IGR1006a gacttactgtcaatgtcatattccacacacagacaaaaggcatgtcccatgaagcaggca cgggctgtggctgagtttgctacataaatgtgctcagatgacaagcatcttaactttcac ttaatcctgaaggtttttcaccctctgttttttgttttgtttttttttttttgagacaga atctcgctctgccgcccaggctggagtgcaatggcacgatcttggctcactgcaacctcc acctcccaggttcaagcgattctcctgcctcagcctcccgagtagctggattacacgtgt gcactagcatccccagctaatttttgtatttttagtagagacggggtttcgccatgttgg ccaggctggtcttgaactcctgacctaaggtgatccgcctgcttcagtctcccaaagtgc tggaattacaggcgtgagccactgcgcccggcctcacccactgtttttataagtatcccc ctcaatttgtgttctcattgtcttcggaaattcaaaggcttgttgttgttgcatgtttgc atccagagtccaggactgcctgactgggagtaaatggaaatgtgagttgcatcttgccta atgaagcttatgtgatgacagacctgcttagagtctgcatgtgtcctttccatggcgtgc tctaaatcttcctactttcctttaccatcctgtcctcata >IGR1007a gtcttcggaaattcaaaggcttgttgttgttgcatgtttgcatccagagtccaggactgc ctgactgggagtaaatggaaatgtgagttgcatcttgcctaatgaagcttatgtgatgac agacctgcttagagtctgcatgtgtccritccatggcgtgctctaaatcttcctactttc ctttaccatcctgtcctcatatacaaactgtaacccactacccatatcctgtggcagact acaactcacattagccattgaatgcaaatgagcctcaatcaaagaagaaaggaaattaaa atttacagtatgtgtcttctccggttggcctgaggagcctccatgactctcatagctatt tattgcccttggcatgctggtattttatgtgggcagggtgaaactggctgtggtcagggt gagacttgaagcttttgatttgttcccttattttgaaagggttaaaaagatgttacatgt tttggtgtaattttagtactcatattaattttgtcacatctctgtaagcgaggatgaaaa gagagtgctcaatcactgttactagatccatattcttacagagaacaagtcttcaaaagg caagttttgatgacacttgggtttttttcccccttttaatttcttttaaataacagcttt attgagatagaattcacctactacgaaatttatcctttta >IGR1008a tcatattaattttgtcacatctctgtaagcgaggatgaaaagagagtgctcaatcactgt tactagatccatattcttacagagaacaagtcttcaaaaggcaagttttgatgacacttg ggtttttttcccccttttaatttcttttaaataacagctttattgagatagaattcacct actacgaaatttatccttttaaagtgtacgagtcagtgctttttagtatgttcatagaat tgtgcaaccatcaccattatctaatatccgaacattttcatcacccctgaaagaaacccc accccccattatcagtcactccccatgcctccacacccgcctcccacccacagcctgtag caatcaatattctatttttgcctctgtggattctcctgttctgaataattcatatcagta gaatcataccatatgtggtcttctgcatttggcttctttcccgtcacatactgtttccaa ggttcatccgggttgtggcctctgtcagtacttcatttctttttattgacaaataatatg ccattgtatggatatgccactttttgtttatccatcagttgattgacattttggttgctt ctacttttttttttttttctttgagacagggtcttattctgtcgctcaggctggagtaca gcagcgcagtcatagctcattgtagcctcaacctcccagg >IGR 1009a ctctgtcagtacttcatttctttttattgacaaataatatgccattgtatggatatgcca ctttttgtttatccatcagttgattgacattttggttgcttctacttttttttttttttc tttgagacagggtcttattctgtcgctcaggctggagtacagcagcgcagtcatagctca ttgtagcctcaacctcccaggcttgagccatcctcccacctcagcctctccagtagctgg gactacaggcatgtgccaccatgctcagctagttttttgtagagacagggttttgccttg ttgcccaggctggtcttgaactcctggcctcaagtgatcctcctgcctcggcctcccaaa gtgctgggattacaggtgtgaaccactgctcccagccacttctacttttttgctattatg aataatgttgctatgaacatttgtgtagaggtttttgtgtggacatgtgttcctagttcc cttgggtatatacctaggattggaattgctggatcgtaaactattttatccttttgagga actgccaattgttttccaaagtgactacaccatttttcaatcactccagcaatgtaggag ggttccaatttttctacatcttcaccaacagttattgtcttttaaatgttatttctttaa tgaaaaaacttcatttatgcacataacacacacacacaca >IGR1010a ttggaattgctggatcgtaaactattttatccttttgaggaactgccaattgttttccaa agtgactacaccatttttcaatcactccagcaatgtaggagggttccaatttttctacat cttcaccaacagttattgtcttttaaatgttatttctttaatgaaaaaacttcatttatg cacataacacacacacacacacacacacacacacacacacacacacacacacacacacac acacacacacacacacacacacacacagacttataatggaaagccgaaagtctccagccc tgtttcacccctccttagtccaagtcccattcccagcaaaccatcttccatttttatttt tagtttttccagtgactatcattataattccaaagattgcttgattcattattttttctt ctctttttattatgaaaactttcaattatgtataaaaggagaatagtataaccaaccccc tgtacacatccccagctgcaacaactgtcaacccatgaccacttttacccactgtttttt gctttatcagtgttagatgtcatacattgatttccctattgaagaaagagaatttaccta attctatcacttccaaatttttatagtaaattatttttagttcttctattacctttgtga ttttgataaatccctaaaccttgtgttcttgttccatcca >IGR 1011 a aacaactgtcaacccatgaccacttttacccactgttttttgctttatcagtgttagatg tcatacattgatttccctattgaagaaagagaatttacctaattctatcacttccaaatt tttatagtaaattatttttagttcttctattacctttgtgattttgataaatccctaaac cttgtgttcttgttccatccactgtgcacagtgttatttaactgccctcttgtccatgca agctggagatagcaatgcccacctctcttttcttctgctttcacctcccagccatttcca gctatagctcttatattattcagtggatagcaatttatagtctgttctccaaccatcatc aagtcttctgtgctttgtctattggttggttctaagacttgagaatcaagagaatttaca ttattatgactttaaatatcgttcactgtagagccatatggtgtactgaggattacttct tttttctgtagactcagtataacaatccttgtgccaatgggggaagaacgttttagacat ccagttgataccttttctgttcagaaatatatggtaatccatagcactcttggacccaag gtgtcttatttacatcttgtatggccttgtgttctttaattatcttgtgtgttatgtccc taactcgagagggaacccctcgagggggaagtggtctttc >IGR1012a taacaatccttgtgccaatgggggaagaacgttttagacatccagttgataccttttctg ttcagaaatatatggtaatccatagcactcttggacccaaggtgtcttatttacatcttg tatggccttgtgttctttaattatcttgtgtgttatgtccctaactcgagagggaacccc tcgagggggaagtggtctttcctgttttgctcccatagcatttatagtctcttggtaaac taaattgatttccctaaaagttgcaaaccataatttcatttgtcaagtaaacatagccaa tacattaaatgccattgctgttagattctatatatactttattttatgatgagttataaa tatataaatacttaaannataaagctatcaaaaactcataaattaaaatattcagctcga acactttgaatatttctctctcatgatcgtctttagcctttccaagaagttttccaacgt actctggttggcttccttcacaggacaggaattctgcaaaanaaacatttcattagcttg cattggtaagcatttgtcttgcctgcctgtctacttgatcaagcctactgtggcacttgt cacctgaacacttataaaaccaaggcctccagtctagcctgactgggagttgtctctatc actaggccagcaggttttgcctattttgggtgcatactac >IGR1013a acaggacaggaattctgcaaaanaaacatttcattagcttgcattggtaagcatttgtct tgcctgcctgtctacttgatcaagcctactgtggcacttgtcacctgaacacttataaaa ccaaggcctccagtctagcctgactgggagttgtctctatcactaggccagcaggttttg cctattttgggtgcatactacttacacttctagaaatggttactgtataccattacctat ctgcttttggggtgggtggcgcgggggggagtgcagtctctggagaggtgtgtcacagct aggtgcttgctcagagggtggaacttgaagatgctggctcagacctgcccggtgctctac tgggccttctgcatgactgcctggactgctgagagagattcagtcatgtggccctcctgt gccattaaacagcagcaccgcagcacagcagccctaaaggtgggaaggattccagatgct acccccaggccactgcttcagtttgaatctcagctctaccatttattaattgtattgctt aggatgtactacttaatttataaaagcttcagtttcttttgtaaagttgggacaattgtt tgcctacttgcctgcttcataagataatggagagaattaaaagagagaacatgtgttgtg ccaagttcctatcccatgacctatcccattgtctacaagg >IGR1014a agtttgaatctcagctctaccatttattaattgtattgcttaggatgtactacttaattt ataaaagcttcagtttcttttgtaaagttgggacaattgtttgcctacttgcctgcttca taagataatggagagaattaaaagagagaacatgtgttgtgccaagttcctatcccatga cctatcccattgtctacaaggtgataggcccagagaggggatacatgtccttgttctcct ctaaagccaattaattcctccactcgatattagataacatccactctgggctacaaggac ttctgccccctaatgattcttcctctttctgctctcttcagttcttcctgctccactgga ccattcccccaggtgcattaacatgctgggtatacccccaaccttaaaagagcttccctc actccataaccaccctgcagctgtgggtcagtttctctgcagccttatagctaaacatct tcaaagagtgttctgccctcactgttccttctttgtctcctctcgccaccctatcctcgg tgagcccactccagctgggctttccttcctgcctctccatttacatcagcctcacccatg gcctccatcagccaaacccaggggcctttcttggtcctcacctgacctgtcctttcagta catttgacacagtcaaccctccctccttgagtgtcctcaa >IGR101 Sa cactgttccttctttgtctcctctcgccaccctatcctcggtgagcccactccagctggg ctttccttcctgcctctccatttacatcagcctcacccatggcctccatcagccaaaccc aggggcctttcttggtcctcacctgacctgtcctttcagtacatttgacacagtcaaccc tccctccttgagtgtcctcaacggcttcctggggtaccgcccactctccagtgttctcct gcctcactggtcactcctcctcaggccccttggctggatcctcctctcctgacctccatg tgttgatctcaggctcagtcctttgatctctccctttctgtcattcagattttcagcagt atctatctaaggactctcctttttgtattgcaagttctgacctctcccctaagttccaga cttttctaaccatcttctcaacaccttcacttggctatccaagagccaccttacatgtac gatgtacaaaattgaactcttgatcttctgctgaacctccagccctgccttgccgccagt ctttcatctctctgtaaacagtactgaccatcgccagaggggtttgggcaggaacaaaga ggtcatcttttcctcccctgtatcttaccccctacaaccgatctgtcagcaaatccttct ggttttatttttagtcatatcccaaatctgttcacctcaa >IGR1016a ttgatcttctgctgaacctccagccctgccttgccgccagtctttcatctctctgtaaac agtactgaccatcgccagaggggtttgggcaggaacaaagaggtcatcttttcctcccct gtatcttaccccctacaaccgatctgtcagcaaatccttctggttttatttttagtcata tcccaaatctgttcacctcaactgctcccattctgtccacgccaccatcatctctagcct ggtttactgtggtagcctcccaacaggccatcttgcttcattctgtccacgccaccatcg tctctagcctggtttactgtggtagcctcccaacaggccatcttgcttcattctgtccac gccaccatcatctctagcctggtttactgtggtagcctcccaacaggccatcttgcttct atgctttccccctttcagcctatttaccacacagtagccagactgacccttttaaatcac gtaaatcagattgtacagtctttgtcctgcccaaagctctgcaggtgttccctgccatac tcgtggtggaatctaaaggccttgtgtgatctgctgtcctggaaactacccctcactcac tctgatccagccacactggccttcctactggtctttaaatacaggaagttagttcatttc catcctaaggcctttgcatacctcctccttctgcctggaa >IGR1017a ctttgtcctgcccaaagctctgcaggtgttccctgccatactcgtggtggaatctaaagg ccttgtgtgatctgctgtcctggaaactacccctcactcactctgatccagccacactgg ccttcctactggtctttaaatacaggaagttagttcatttccatcctaaggcctttgcat acctcctccttctgcctggaatggtctccctagttagtcatgtggcctgctccctcaatt caaatatctgctcagataatgtcaccagctcctaagtcagccccctcccccatgactctt atgttctttatttctatgtttttctttgtagcacgtatcactgctggccatcattttaca tgtttgtttttctaactctcccattagaacattccatgagaacagggactcggcctgcgt gtctttagtgacacgtcctcagcacctagaaccacacccagcacttgtggaacttcagca aatacttattgaatgagtgaatgaatgaatgggttgaccaagggtgctgcagctcccaag gagtgtttagaagtgaggctgctgtccaccaggagccacgcggccggcttgccaggaata cagtgcagcttaccaagcccgccaggccccagaggttcctgtcgagccgtttcaggaatc ggatcagctgcttgtgcctgtggaactgctgtgcagtcgc >IGR1018a aatgaatgaatgggttgaccaagggtgctgcagctcccaaggagtgtttagaagtgaggc tgctgtccaccaggagccacgcggccggcttgccaggaatacagtgcagcttaccaagcc cgccaggccccagaggttcctgtcgagccgtttcaggaatcggatcagctgcttgtgcct gtggaactgctgtgcagtcgcacccaggcagcgagtgtccttctcatggtggctgtagaa ctgccggagcacagtcgcagccctgcagaaggtttccttctcagttgtgttctggaaaga caaatgccacagatagcaatgtgccagctccatttggaggatgggagagagatttttcct cttgatttcttctttccaggaggacaaatggaggtgagtttgctcaactacagacctgtc ttcaagtattccactgaaggaaggctgcttgccacagacataaacctctgtcaacaacct ctcccaattgcaaacgcagcagccttctccccagaacctcccagtttcctttctcttgga ggattttgccgaaagggtacctgaataaagtcatcccatgaggaaaaggcacagtgggga ctagaatgcaggaccatctgtcgctacagcccacgttctgcgtccgtgtctctatacctc atgagctattctgctatgaaaagtgcccacatgagctctc >IGR1019a cagccttctccccagaacctcccagtttcctttctcttggaggattttgccgaaagggta cctgaataaagtcatcccatgaggaaaaggcacagtggggactagaatgcaggaccatct gtcgctacagcccacgttctgcgtccgtgtctctatacctcatgagctattctgctatga aaagtgcccacatgagctctcagtcaggttctgctcttgttcccagaggttttaaaatcc agctttccctggaaatcctgcatgcctgttgaataaatgagtgcacatcctttggcctga actctgctgctttggccagcactctccgtgtggctctccccatgggagaggagagcagca catggcccaagtgaggagctaagacattttgccaggcagcaagagataagtgcacagatc agggaaaggtgtcctgggagatcagaggaggctctgggagcaggtgccattgatctgagc cttgggcagagcttctgtaaggggccttttggccccaaatgatgcggagtgagaatctcc ttggaatgccagcaactgtgagggtctggccacatggctcttcctgggggcccttagcct tagagaagggaatggacaagagacaagtcattgggaacccaggagagggattgtgtctca gtctgaacctggcctggtgtgtcctctcatttttcactga >IGR 1020a aggggccttttggccccaaatgatgcggagtgagaatctccttggaatgccagcaactgt gagggtctggccacatggctcttcctgggggcccttagccttagagaagggaatggacaa gagacaagtcattgggaacccaggagagggattgtgtctcagtctgaacctggcctggtg tgtcctctcatttttcactgaagaacaaagatgcagaacctggagagggttcttagcttg agcccagttcctttatccagttcagataaagaaagctatccccagcctctcccccgacat gctctggtcccttgatactcaaagtgtggtccatggaccagcagcatggacatcactggg agcttcttagaaatacagaatctcagaccacccctgccccacccagaccctctgaatcag aagaacagtgacaagatgctcaggggtttctatcagcagcgctgtccaagcagctttcaa gttcttacatatttttttttctgatgatcaagataacatatatttactataaaggtaaca tatattcaacaaaaatacattcactcatcccaccagccagaggtaactattgctgttaat attttggtaaatatcgtcacacttttaaaaatactttttaaaataggggtcaactgttga tactgttttgtaacttctttactctttacatataccataa >IGR1021 a tctgatgatcaagataacatatatttactataaaggtaacatatattcaacaaaaataca ttcactcatcccaccagccagaggtaactattgctgttaatattttggtaaatatcgtca cacttttaaaaatactttttaaaataggggtcaactgttgatactgttttgtaacttctt tactctttacatataccataagcatttcctaagcccttcggtggtattagagaacatggg attgagagctgcgtagaaacgcattgcacagtggtactgtcatttgtcaggcccctatcg tggcagatttttgcttctgtaaataagcggcagtgagtaaactatagaaatctttgtgtt catctcttatttatgtaggctaaattctaggaatgcagttcatattttaacgttttttca ggaaagtctagacccagactgaggcaccagaatcccaggctacagaagcttcccctttcc cctgtggggcgtgatgtcccatgggcagagcggttagaaagacatttacttaatgaactg actgagagtcactcctcgttcctgattctagttggaaatgtaagagtgtgtcagtatctt tgggctctgggggccaagaaacagacctctctgggctttgtaggcgagtcgaggtggaag ggacacgggctgatggggggcggcagatggtgcctgtgtg >IGR 1022a catgggcagagcggttagaaagacatttacttaatgaactgactgagagtcactcctcgt tcctgattctagttggaaatgtaagagtgtgtcagtatctttgggctctgggggccaaga aacagacctctctgggctttgtaggcgagtcgaggtggaagggacacgggctgatggggg gcggcagatggtgcctgtgtgtctggaggtgggcagacatgcatgctgctgcagagggaa cagtgagattcaagaaaaccaaaaagtcagccctttgcttcttttaccacaaaccttggt gagatttttctgaaacgctggcttggagcctggaaattaaacttaattttgacccgtata tggccacatagtataggaaaaaaccctctaaagatatttttgaaaggactttctaaagga aacaaggataaaataagaattgaaaagagtctgcattaaatggaaaaactttaaaagaat gcatcctaagggcagctttagtgcaaggccttaacgttttagttgctctggtatcgcagc gagggggcgacactccatccctgccgtggccctggactcctaccacctgcctgtctagct ctggctgctgagtgtgtctgccagtggctcagggagtgcacttggacagcctggctgacc tcacagttcagaactgcttagggagtgactcagaaggagg >IGRl 023a agtgcaaggccttaacgttttagttgctctggtatcgcagcgagggggcgacactccatc cctgccgtggccctggactcctaccacctgcctgtctagctctggctgctgagtgtgtct gccagtggctcagggagtgcacttggacagcctggctgacctcacagttcagaactgctt agggagtgactcagaaggaggcctgtccctcccgggaatgtcaggaaacagccacttggg agatttcttctgtggcagtgactctgtgagagttctaactcggttcttgaccagcctcac tgaggaccatataaatccagcccgattggcactgcattcattatctcccatcctgcccag gatagtcagctagtgctgtatatgagaaactccttcaaaaaacagaggtatttgaggttc attatggaactctctgtagaattatgaactttagctctctttggtaaataggaaatngct ccaactacttgtccacccaagaaacccttcatcagccagccagcttgcttcttcccactt tgctgttcctcagacagccttgacttcatagacaccctgacaggtgttacctgtgaagcc caggacctagaccagtgccttctttccagcaactgccaagagtagaatgctacccaactt agagatactaaaattcttgttcccccgaagaaataaaatc >IGR 1024a agaaacccttcatcagccagccagcttgcttcttcccactttgctgttcctcagacagcc ttgacttcatagacaccctgacaggtgttacctgtgaagcccaggacctagaccagtgcc ttctttccagcaactgccaagagtagaatgctacccaacttagagatactaaaattcttg ttcccccgaagaaataaaatcaataggctggattttggaaagatgttttctttgggaaca caaagaagtaccttttcctctgcataccacctttgtaggtttttgaaaatagcaacattt cactgttctgaaatatcttaacatgtaagtaagcagtgctgaatcttcgaggggaagaaa agagtgaagagtgagatcgtgaactccaggaggatgaagttcaggggaggcaaatgagac gggtaagagtgaaggcaggcagtggggattattctaggagatgtttgtgtgtgtgagagg gaggtgagtgaggactgagtgaagaggggagttaaggacgggagggcagcagtgtcctgg cctgcacccgggggtcttccagaaacagcccagatggattgccccagactcggcatcctg gatggtttgatcctttccaacccggtcccctccttcttagaatcatcgcttctctgcacc tgttcttgcttttaatcgtggttatatcatctcacaataa >IGR1025a tgaagaggggagttaaggacgggagggcagcagtgtcctggcctgcacccgggggtcttc cagaaacagcccagatggattgccccagactcggcatcctggatggtttgatcctttcca acccggtcccctccttcttagaatcatcgcttctctgcacctgttcttgcttttaatcgt ggttatatcatctcacaataacactttgcactaactcaagagctggattccaatcaacct tgcaatcaccttcagaatcactttcatatcttcacatgtggaaactgaggtgcagagagg tgtgaagatgtgctgaaggccagccacacagctagtcagtggcagagctgggtctaaaac cacaggcagtcttacctccaggccctcagccctcacccttcctccaggcctggcttctag tgaggtggcccttcccttggctttgttagagccttctcagcagtgccacaggcctccaga gacccagtgctcaacccggtggactcttggcttctagtaggagccatctcggttggatgg acttggagattttatacacacacacacacacacacacacacanananatacanananata natacanacananatatananacacacananananananacacacacacacacacacaca cataaactgttgcccaggtgcagtggctaatcccagcact >IGR1026a tggactcttggcttctagtaggagccatctcggttggatggacttggagattttatacac acacacacacacacacacacacanananatacanananatanatacanacananatatan anacacacananananananacacacacacacacacacacacataaactgttgcccaggt gcagtggctaatcccagcactttgagaggccgaggtggacggattgcttgagcccagaag ttcgagacaagcctgggcaaaatggcaagactccatctctacaaaaaaatacaaaaatta gccaggcgtggtggtgcacacctgtcgtcccggctacttgggaggctgaggtaggaagat agcttgagcctgggaggtggaggctgctatgagctgaaatcgcaccactgcactccagcc tgggtgacagaacaagaccctatctcaaaaaaaaaaaaaagtgtgtatttgcccttcaga atctcatcctgtatcggactcccgggataactaatgaaatgagatagtccagctaaaggc ccgaagagcagtttccctcatgaagcaggatgggccctgttctatggtctgggtgctgga gtgtgaccctgcccaacacacagggcttcactcctggccatatcatctccctagtttgca tggaaagcaggtagttaggagaccactgtgaaattgaggc >IGR1027a tcccgggataactaatgaaatgagatagtccagctaaaggcccgaagagcagtttccctc atgaagcaggatgggccctgttctatggtctgggtgctggagtgtgaccctgcccaacac acagggcttcactcctggccatatcatctccctagtttgcatggaaagcaggtagttagg agaccactgtgaaattgaggctttggggctttcattctcagccgtgtgtttccatgaaaa caggaactgaaatgcacaaaactattgatacggctgtagtcatgtgtttgtcagagaaaa tgcactatcagctgtcaaatctatctcctcccactacagatagaggggtgggggtgaggc agcacaggaggcagagaggcgaggtgcccaggcagcccgaagcagggatgtgctggacgc tgcccagcaggatggttccagaccgagctggaggggagttcggccggccagagcaagctg aggagctctggacggcgagccccggaacccagagggctgttaggtggccaggctgtggaa gaggaggggctctggcgataccttttctgttgccataggaagtctcttagacaaaatgaa agctccctcaacctgtcatctcaatatctgtttctgtgagagtatttggtttttcagaaa tgtatgggccagaaaaattctctcattcaacaggcattta >IGR1028a ccccggaacccagagggctgttaggtggccaggctgtggaagaggaggggctctggcgat accttttctgttgccataggaagtctcttagacaaaatgaaagctccctcaacctgtcat ctcaatatctgtttctgtgagagtatttggtttttcagaaatgtatgggccagaaaaatt ctctcattcaacaggcatttattgagtgcctcctacgttccaggcactatgccaaagcta agtaaaacccaagagggcttttctttgaccaggatctgagtcaggactacagcatgtaag ctttctattacatgtcttctaaatcaagtgaaaccagaaagaccaaaacatgcttaagag taaagatcagacttctcgttctttgaaaacatctaacaccttagagttaatttgggcccg ctcgttttccattagacaagtttcttgttcagacatttggggatggatcnccccatttgc taaaacagaccgtgggacggcttcttaccttggaggcagcaaagatgtctgttacggtca actcggtgcacagagtcttggtccaggcagaaatgagagagcaagagacagagttaacct ccaaccggacagagaagtccttgatgagcagctctcactccctccaactgaggaaacttc ctacaaaccctcagaaaaaagagtggcaggggagaagcct >IGR1029a gcttcttaccttggaggcagcaaagatgtctgttacggtcaactcggtgcacagagtctt ggtccaggcagaaatgagagagcaagagacagagttaacctccaaccggacagagaagtc cttgatgagcagctctcactccctccaactgaggaaacttcctacaaaccctcagaaaaa agagtggcaggggagaagcctcgctgtgtgccctggactgccaccaaccaccagttccaa cttctctagcagctgttaacgttttcatgcctagaaatactgagagcatcaccagaacat ctggagagatggtgccagataggtactcaccttctgctctgtgaggctgttcaaagtttt gatgatctcctgtaaggtgatatcgcacttgtgtccgtggacaaagttgccggcacatgc tagcaggaagaacagagggggaagcagttgggaggngagacccattaataggtgtcgatt tgcagtgacaatgtgagncaattagtttatcaggagaagctaacgatncaatgctgacaa agatatctctatatatagatttaaaattgctgaaaccgagggaaaatgagtttacattgg aaattttcgttacaccagattgtcagtcacttggggccaatcagcacctctcttccagga gaaaaaatgcctcacaaacaggtaaaatgttcctgtgaaa >IGR1030a aattagtttatcaggagaagctaacgatncaatgctgacaaagatatctctatatataga tttaaaattgctgaaaccgagggaaaatgagtttacattggaaattttcgttacaccaga ttgtcagtcacttggggccaatcagcacctctcttccaggagaaaaaatgcctcacaaac aggtaaaatgttcctgtgaaatcagaccaataggaaaatgaaacctttttaaaaaattaa ctacaaagtttcagcataggaaattacaccataatttgctctttagattaatcttatcag cttggggctgctgctggctttttgctttgcatagaagggagaggccacaggtgtccgaat ttgttgtaatgcagtcctcctggggaaagatagagtaatatcaagaaagttttacttgaa aagtattttaacctggcttcttccaagtacaggtggcatcttggaaactgtcctgtcatg gaaaagctgatctggggctccttctctgcatagaggcagaataacaggcagactctccta ccccagcactggggnacaatgttctcccaagtttaggtgttttgagaaggacaggtcgta tcaggtgaggcctagtttgggtcccagcaggtccataaggtccttacccataaggaagcc cttggcaaggtaggtctattctgaggtttcaggaatgact >IGR1031a ccttctctgcatagaggcagaataacaggcagactctcctaccccagcactggggnacaa tgttctcccaagtttaggtgttttgagaaggacaggtcgtatcaggtgaggcctagtttg ggtcccagcaggtccataaggtccttacccataaggaagcccttggcaaggtaggtctat tctgaggtttcaggaatgacttttttttttttttttctgagacagggtctcactctgtca cccaggctgaaatgcaatgttgtgatcagggatcactgcagcctcaacctcccaggctca agtgatcctcccacctcagcccccctagcagtaggtgcgtgccaccgcaccatgcctggc tcatttttatttttattttttgatagagataagagtctcactatgttgcctaggctcatc tcaaattcctgggctcaagtgatcctcctacctcagtctcccaaagctctgagattacag gtgtgagccaccatgcctggccaggaatgcccactttttgaatggaacctaaacacatcc tcagctaattaggaaaaagagctacagtcttaccaacttacaaatcagccctcctagtca gtgccccaccacccgccctgcttgttttttattgaattcatgtggacacaataaggtgct cattgcctcaccccagcagtgaacgtaaggaccccaccac >IGR1032a gccaggaatgcccactttttgaatggaacctaaacacatcctcagctaattaggaaaaag agctacagtcttaccaacttacaaatcagccctcctagtcagtgccccaccacccgccct gcttgttttttattgaattcatgtggacacaataaggtgctcattgcctcaccccagcag tgaacgtaaggaccccaccactcactcaggtgcctgggccctgtgcaaggccaccccacc tcccagtaagggctcatgggcagcaggattcttgggccctgcctgccccctgcttttctc ccagaaccttcccttcccttggtctctgaccttcttttccctatgaatttcttttttttt tttttttttttgagatggaatcttgctctgtcacccaggctggagtgcagtggcgtgatc ttagttcactgcaagctccgcctcctgggttcatgccgttctcctgcctcagcctccccg agtagctgggactacaggcacctgccaccacgcccggctaattttttgtatttttagtag agacggggtttcaccgtgttagccaggatggtctccatctcctgacctcgtgatccgcct gcctcggcctcccaaagtgctgggattacaggcgtgagccactgtgcctgggcctcccta tgaatttattctggaagatcatctaaaaatgtgtgttgct >IGR1033a acctgccaccacgcccggctaattttttgtatttttagtagagacggggtttcaccgtgt tagccaggatggtctccatctcctgacctcgtgatccgcctgcctcggcctcccaaagtg ctgggattacaggcgtgagccactgtgcctgggcctccctatgaatttattctggaagat catctaaaaatgtgtgttgctaaggttttgcctctgttccacttccccgcccccccctca ccaccccctgcccccatactctgtcacccaggctggagtgcagtggtgatcatagcttac tgtagccttgatctcctgggctcaaggcattctccagcctcagcttcccgagtagctggg attacaggcacatgccaccacgcctggctaatttctgtattttttttttttttttagtag agatggggtttcaccatgttggctaggctggtgtcgaactcctggcctcaaaatgatcca cccacctcagcctcccaaagtgctgggattataggcgtgaaccaccatgcccggccaagg ttttgcctctgttttggatcttttcttcccttattattattattattaaattgacaaata agtattgcacatatttgtgctgtatgatataatgttttgaaatgtgcatgttatggaatt gctacatcaagctacttatacaatacttcacatatttatt >IGR1034a gtgctgggattataggcgtgaaccaccatgcccggccaaggttttgcctctgttttggat cttttcttcccttattattattattattaaattgacaaataagtattgcacatatttgtg ctgtatgatataatgttttgaaatgtgcatgttatggaattgctacatcaagctacttat acaatacttcacatatttatttttggtaagaacatttaaaatctactctgtgatttattt atttattttgagatagagtcttgctctgttgcccagactggagtgcaatggcgcagtctc agctcactgcaacctctgcctcctgagctcaagcaattctcctgcctcagcctcccgagt agctgggattacaggtgcctgccaccacgcccagctaatttttgtatttttaatagagac agggttttaccatgttggccaggctggtctcgaactcctgacctcaggtgatctacccac ctcagcccctgcaaagtgctgggattacaggtgtgagccactgcgcctggcctgtcttca tgatttttaagtatacaagacattgatatcaactgttgtcaccatgtcgtacaatggctc tctttaacttaactcctcccagttgaaattttatatcctttgaccaacatcttcctgatc accaccctcccagcccctggtgaccatcatcctactctct >IGR1035a tgggattacaggtgtgagccactgcgcctggcctgtcttcatgatttttaagtatacaag acattgatatcaactgttgtcaccatgtcgtacaatggctctctttaacttaactcctcc cagttgaaattttatatcctttgaccaacatcttcctgatcaccaccctcccagcccctg gtgaccatcatcctactctctgcctccctgagtttggcttttttatatttcacatatgcg tgagatcatgtggtatttgtctgtctgtgcctggattttttcacttagcataatgtcctc caggttcatccatgttgtggtgaatgacagcgtttccttcttttttaaggctgtatagta ttccactgtctatatatagttttggatcttatcgcagtgcctcaagttctgtgaaggaga gaatctggataattgtatcaggaggtccttagaccatatttaggatccttccattgggac tgggcagcaaggttaccaaactaaatgcagtggcttcagatgccaaaccacctgagatga gccacacctcacaggtgaggggtatggtcccccacaacactgcccttgcttcagacgcca gctgcacattcaggggttcccagcccaccctcactgctgactggctgcaaatctgggagt ttccactacccctcaggttccagaatgcactaggatgact >IGR1036a actaaatgcagtggcttcagatgccaaaccacctgagatgagccacacctcacaggtgag gggtatggtcccccacaacactgcccttgcttcagacgccagctgcacattcaggggttc ccagcccaccctcactgctgactggctgcaaatctgggagtttccactacccctcaggtt ccagaatgcactaggatgactgacagaactcaggagagtgctatacgtaaggccacagtt ttatcataacaaaagcattcaaatcagaaccagccaaaagaggagacacaggggcgagat ggaggaggggcccaaacacaaagctctcattgtcttccccgtgtggcgtcagaggcatca ccttctcagcactttgacgtgtgacaaaatgctgactatttctaagcagggaggctcact tgagctttggggtccagagtttttatttgagtcttatcatataggtgtggttgatggact cattggccactgggttgaactcatcttcctggtctccttccgggaggccaggctgatatc acagaacctcagtggcgtggccagcccctccatggtcgtattgtcagcaaaaactaccta gggcccaccatgagtcacttcactcgcataaactctcagagaccaccatgaataataaga tactcctatcacttgggaaatccctaggaatttggggcta >IGR1037a ctcatcttcctggtctccttccgggaggccaggctgatatcacagaacctcagtggcgtg gccagcccctccatggtcgtattgtcagcaaaaactacctagggcccaccatgagtcact tcactcgcataaactctcagagaccaccatgaataataagatactcctatcacttgggaa atccctaggaatttggggctacctcctgggaactggtgacaaggactagccacgttgttt actccaagggtttgtagctggtaggacctcccaagagccaggacaaaggccagacttctt ggataaaggttgattcttcactgcacaaactggaggagagttatgagaagagcaggtggt tgcttccaaagcaggtggggactttggatccgatgaactattatgtggaatgaagtacag cagcggttccagttaacacaggagggagctcatcaagctgcggacttgctgggtggagag cttctgccaaataggttctcaaggagagtcggggatgcagaaggggagctggtggggagg gcggggttctggggcgtctgtgggggcagtggaacagccatttatgtgtccatctggtgt ttttctaagcacccactaaagggcagaccctgggcttgaggctctgagggcagagctggt gagtgaaaagggaatattaggtgggcaccttcagctcaga >IGRl 038a caaggagagtcggggatgcagaaggggagctggtggggagggcggggttctggggcgtct gtgggggcagtggaacagccatttatgtgtccatctggtgtttttctaagcacccactaa agggcagaccctgggcttgaggctctgagggcagagctggtgagtgaaaagggaatatta ggtgggcaccttcagctcagaagcagaatccagcttgttttgtttgtttcaatggtgaaa tgaggccaaagatgaaaggataaactgtccagaacattcgagagtgaccaggagtctccc cagagggcagaagtgggggatgggccatcctcgcctgcagggacagcaccatggcagctg caggtgcggcaggtgggtagagatggggaaggtgggtgcctgcattgtcagggacaaaga ggagggcagtgatcaccaccactaccaccactgcgaaggagtctccgagcctgcagggcc atgggcagtgccttggcggggtgtggtgggcctgacaccaaagttcaggagggaggttga atactgctgtctctggctgtgtcggtcacaggccccttcccctcccctgtgtgagagctg agaaccagcgccggcccctccatggatgcagagtttttccttcaggccctggaacgtagc agttatgagcactgcgtttgggagtccagcaaatgagccc >IGR1039a ggtgtggtgggcctgacaccaaagttcaggagggaggttgaatactgctgtctctggctg tgtcggtcacaggccccttcccctcccctgtgtgagagctgagaaccagcgccggcccct ccatggatgcagagtttttccttcaggccctggaacgtagcagttatgagcactgcgttt gggagtccagcaaatgagcccttatcaactctgtgaccatgagtagatcattaactctct ctgggtctcgattttctcacctgtgaaatgggaataatgtggctcttccttgtgaggagc aagtgagtggttccatggaaagtacttggcatgtgtcatccagaaagggggtctgttaac agaggctgctatagtacacggtggctaagagagcggacgctgggcccaggtggtctgtca ggcctggctgctgtgcctcctggctgtgtgaccttgggcacgctactcagcctcatctgt gaaataggggtcatagctgtccctgtctcatgaagttgctctgaggaatgaatacattta aagttttcaagtatttagaatagtgcctggcacacagtgagtgtgatgatgataatgatg actcctatcttgagttgctgaaatgactgatgcttcatctattaggcaagcccaagtctg gacagggcagtggagatctggccagacgggccctccccac >IGR 1040a tccctgtctcatgaagttgctctgaggaatgaatacatttaaagttttcaagtatttaga atagtgcctggcacacagtgagtgtgatgatgataatgatgactcctatcttgagttgct gaaatgactgatgcttcatctattaggcaagcccaagtctggacagggcagtggagatct ggccagacgggccctccccacaggttcctcctggatgtgcctcctccgtctttgagttgc cgtccttgtttctggtgggtcacggtctccacactgcagcccgcctactttagtatctgg attcattacagggaacagacacagctgtgggtgctttagtcaggaaaggatttcatgcag gaaagtaggtgcttctaagaatgtcaggagggctggaggggcaggctccaggctgggccc agaaccctaaagacctgacccactcagcgagccacccctgaggctgcagtgccgggattc caaagctgctgcctctgctgaccccctacactgtgagtctgctccaggagactcccggtc tgacttccacaccatgagtctgctcaaggacacccctagtctgaatgaccaggtacatgg tatctgccgccctcccctccacagcttgtcagccttcatctaattggaaaagccagatgc tcgcttcaaaggagtcagaaacgcggcagtcaactaggag >IGR1041 a gaccccctacactgtgagtctgctccaggagactcccggtctgacttccacaccatgagt ctgctcaaggacacccctagtctgaatgaccaggtacatggtatctgccgccctcccctc cacagcttgtcagccttcatctaattggaaaagccagatgctcgcttcaaaggagtcaga aacgcggcagtcaactaggagaaaggaatacaggtcgcacaatgcagcccagtctccacg ggcctcgttcattgatgcttgctgtcccagccattcctgtggtccgagtcgggtgaatct cacctccctcctcttctgtcagtcctgcaggccagcacccaggagagtgctttccaaccc ccacaggcttagtcatggaaaaaggtgagacttctctgagggaggggcacttaagcagag ttagggatgagccggctttagccaggagcaggggctgcagggtggggtgagtgcgggcaa gggacagcaggtggaaggccccgaggtcactgaagagagggctcccaggaggggagcacg ggccgaggggacccagccagagcattgcaggcgcccgtgacagaggcagctggcgcgaat cgggtgggatggtggcagggagagctgtgggctcttgagtcatttggcccagcacagtgt ctaggttaagacctggtgtcttggtgcccacgggacctga >IGR1042a cccgaggtcactgaagagagggctcccaggaggggagcacgggccgaggggacccagcca gagcattgcaggcgcccgtgacagaggcagctggcgcgaatcgggtgggatggtggcagg gagagctgtgggctcttgagtcatttggcccagcacagtgtctaggttaagacctggtgt cttggtgcccacgggacctgactggttctgaatcccagctctgggtgaccttggaaaagt tcccccatccaggcttctctgtaaaactgggctgattacaggggcgagggaatactatag aaggtgacaaatatgaagtgtttggtgtggtgaccggcatattgcaagcccccggaaaat gccagcaatcaccatcaccaccaccatcatcattaatagcacttggaagtgactgaatgt gggggtgagggagagcaggaagtcgcaggtggccccaggtctctggcttggggaggaggc aggggagagggcaggcggcgggtggnagccaccagctgaggggctgctacgggccatact ctgagaacaggggagggtccagcctgcaggcagtagacatggagggtgactaagccaagg ggaagaacacagtgttgctggaaaaaggggtcccgattcagaccccgagagagttcttgg atctcgcacgggaaggaattcaaggtgagtcgtggtgtgt >IGR1043a gggtggnagccaccagctgaggggctgctacgggccatactctgagaacaggggagggtc cagcctgcaggcagtagacatggagggtgactaagccaaggggaagaacacagtgttgct ggaaaaaggggtcccgattcagaccccgagagagttcttggatctcgcacgggaaggaat tcaaggtgagtcgtggtgtgtggtaaagaaaggatgtagaaaactactcagagtagggtg tcctcagaaagcatgagcaggaacgccttgtctgcttaaagcttttcttatataggggtc ttgtctatacaaaagccaagctacattatgtctatgtgcaggtgggctgacagtgtcaca aaatttagtactttgttgatttaaataatgttttatccttggccttttagtgagtaagta catcaaagcattactgtaaatagcttgaaagcatatattgttatgagacatcaggacacc cagacattctgctgttgtaggagtttgtccttgcgggcgtgactaaactgcttccttggc gtaaacatctcatgaccatgggtagtgactggcaaggaatatgcctagctagttttaaga tggagttgattttaaaatggtgtcaccctggctctcctccactcctgttgacctaacaat atggccaaggggtgagagaagacaggggacaagaaatgag >IGR 1044a ggagtttgtccttgcgggcgtgactaaactgcttccttggcgtaaacatctcatgaccat gggtagtgactggcaaggaatatgcctagctagttttaagatggagttgattttaaaatg gtgtcaccctggctctcctccactcctgttgacctaacaatatggccaaggggtgagaga agacaggggacaagaaatgagccagggcactcctgcgacactggaaggtggtgaggcagg gtgcagagtccaggcatgagagaggcccagggaggaggagcagtggtcagcggcagcaat gttcctcgtaggtgaggctagataagggcagacatgcgttgctgcacggagtggagttga taatcagtgacctcatgagatatctgagtgcagttgggggcacaggaagtggccagatga ggtggaactcagtatgggcatctgggagggcagctgtgttgggctgcaggctgcgtcgta ggttgtcagctgtgttctgaatgggacacaatcaagcacaggctgccccagctcagcgag cggcagcttcatccttgcagttgttcacacacaacacgggaagacctcacacgctcatat ccaagccaccccaaagcctctcctttcactgatgtgacatctcggattggtggtggtggg gaaggggcgggggtagagatggaacaaaattgacaaaact >IGR 1045 a aatgggacacaatcaagcacaggctgccccagctcagcgagcggcagcttcatccttgca gttgttcacacacaacacgggaagacctcacacgctcatatccaagccaccccaaagcct ctcctttcactgatgtgacatctcggattggtggtggtggggaaggggcgggggtagaga tggaacaaaattgacaaaactggccatgagttgctcattgttgacgctgggcaatggatg cttgggagtgactttcgtgtatatttgaaattttctgtaatagaagattttaaaattgta attgcatagcaaatgtaaatattaacatatatgcacatttatatattatatatttanatc tatactttatggattatataatatactatttaagtaaataatgtatacgatagcagtata atgtatacatgcatcttacacacacgcccctctccagtcctccactaccacaagcaccat cgctccccaccagcatctctgcaggcaccttggcgctcatctccctgctccgccttcgcc ctgcgttgcgttctccacacagcagccacggtgactttgttaaaatgtgagtcagaccac atcactccattccacttagaatgaagcccggtcctggcctctgaggccctgctgggntcc tgctgcccttgccgtggcctctgctccagcccgagggcca >IGR 1046a tgcaggcaccttggcgctcatctccctgctccgccttcgccctgcgttgcgttctccaca cagcagccacggtgactttgttaaaatgtgagtcagaccacatcactccattccacttag aatgaagcccggtcctggcctctgaggccctgctgggntcctgctgcccttgccgtggcc tctgctccagcccgagggccacccgtgagtgctgggaagggcatccccagctcgctcttg ctcaagaccttagcacctgcagttccctttcccttgatgactttgccccgatctgtgcat gggngtcccctnccccttgtttcgtcccgatctctgttcccatcttatctcatggggagg atttctccaacctcctcgcataacacagcactctccctgctgtgcagccccggactgttc tatttcccacggtagcggctaccaccgcccgacacactgagtgttctctcgttggcttat tctgtctccctgctagaagcaaccttgttttgtttagtggacccccagcacctagagcag ggtctggcacccaggcaaggcctcaatccatacttgttgaatgaatgagtggagctccat ttccacggagccactgagacgtggctgaagtaacaacactagaagtcagggacacagctg gggcttgaagctgggactagtttcaccctgagcccccggc >IGR1047a caaccttgttttgtttagtggacccccagcacctagagcagggtctggcacccaggcaag gcctcaatccatacttgttgaatgaatgagtggagctccatttccacggagccactgaga cgtggctgaagtaacaacactagaagtcagggacacagctggggcttgaagctgggacta gtttcaccctgagcccccggctatatgctctgcctgtgttcctgagaggggaggggatgg ggcccagagcacanacacatggagggccccatccaagggcacagggaccgaggggaggag agaaacgaggctggcaggcagtggcatagactccgctttgcggagctgtggggaagtagc tctgcaggctgttggcttctcttgcctttcagaagcaggtggaaggtccttctcccaaga gaggcagagctgctgaggagtctgcaggaatgctccatctgtccccatagtgttaatgtc acttcagcctcagagctagatgggcggcctaccctttcccttcccactcccgctggctcc tgtgccctggcaggccagggcctagtgaagacccccaagaaggcagcaccttcctctgtc tttggcaatgtgggatctgatgggtccaagagtgcccaacccatgggaggagcggtgcta gtcctgtctggctgaggggctgccttgcaggcccctgcag >IGR1048a atgggcggcctaccctttcccttcccactcccgctggctcctgtgccctggcaggccagg gcctagtgaagacccccaagaaggcagcaccttcctctgtctttggcaatgtgggatctg atgggtccaagagtgcccaacccatgggaggagcggtgctagtcctgtctggctgagggg ctgccttgcaggcccctgcagacccccacctcctctcccgagagggccggctccccaggg aggacttaggctggtctgaggggtgctggtgctggtccagccgggggatgctgcaaccag gtctcctcactggcctgtctcggtccacatcctccatggagcagacatcacgttcatgtt ctttttgctttttaaaaatgaaatttatccttgtctcccattggaaaatgaatgcatgct cattatagaaaatgtgggaaacagatcagaagaaagaagagtaaataaaaattgcctttt ccaatgtggcatcaccacagctcctctggcacagggccctgggctgggcagggagttgtg gactgtgtngccaacaggccatcgggctgtgggtctacaggggatgccatcggtggcttg ggccttcctcccttgagggtttggggaaatggtgtccagcccccgcacagttgtccacag tgatgcagagagtggagctgacgagagttgctatatttaa >IGR1049a gctcctctggcacagggccctgggctgggcagggagttgtggactgtgtngccaacaggc catcgggctgtgggtctacaggggatgccatcggtggcttgggccttcctcccttgaggg tttggggaaatggtgtccagcccccgcacagttgtccacagtgatgcagagagtggagct gacgagagttgctatatttaattttggtgcctgcgtcacctctgaccacacagcagcgtc tgcccaggcaggcagcacatggctgggggtgtttctgaacgacgctgtgagagaatcact ttccccaagaaaaggtatagcagaggggaagggagagacagcaacagaaagtgaggtcgt aagtagaaaattgcttctgggatttcaaatggctttgtcatggggccctcccttnctgcc gagaaatcagttgatctgggaaagtttgttgcaaacccttgccctcttgcttttgggtgg agctgagaaatgaatgaagataatggggctttatgagtgtgggggagggtagctgaggag acagccaccagtcctgaccccagcttggacccctagaaaggccagataggagctggccag tgtgtccctggccaggctgtcctgtctggaacatagtcagcctgnccccagccggacctt cttagaagggaggcaggcgaagtgggaaacaggtttggag >IGR1050a ataatggggctttatgagtgtgggggagggtagctgaggagacagccaccagtcctgacc ccagcttggacccctagaaaggccagataggagctggccagtgtgtccctggccaggctg tcctgtctggaacatagtcagcctgnccccagccggaccttcttagaagggaggcaggcg aagtgggaaacaggtttggagtgtgttacaatgcaccagctagatgaagggcataggcag aagacatttctctttgaccctaatgaaaaagcgataagccgctgggccaggtgaaggcca ggcttcaagctgctgcctcggtcacaaggaaataagatgcgggcctggtccccttggggc ctgctccttctcgtcctgcgcaggacagggggccagcctcggagaaacctgccaagtgac tgggagcattttctgacacctcatctgagcagcaaactgaggtgtttggtgccgagttca ccggaaactcgcgtgtgtctcacttctcactcaagcccagcctctcttccagtgaaacct cctgggctggggttcccgaggtgccaaggggctccccgccctgggccccatggccagcat cttcctcccactcaccaagcactcttctcccttctcaacccccttctctctgagtcctgc tgagggcttgccttgtttatgaaagaacttaggccacgtg >IGR1051 a tcacttctcactcaagcccagcctctcttccagtgaaacctcctgggctggggttcccga ggtgccaaggggctccccgccctgggccccatggccagcatcttcctcccactcaccaag cactcttctcccttctcaacccccttctctctgagtcctgctgagggcttgccttgttta tgaaagaacttaggccacgtggttagagaaaactcccagcaaacaccaccagggctcagt ccccagggagggaggttcccagccacagttgcagtgctgacacttacctaccttgttctg tcttcctttctcattcctgacagggccccttccctgtcgccaccagctgcagcttggttc tgtggctcagtaaggtgtcactcatccctggagagccccacgccctctccagcccagggc acactgccagtgaccacaggtcccccttcctggggagcagcctggaaggtgtgagggaca ggagctcggcggtggctgaggaagtggcgagctgcagacccctagtggggcccgggacgg ccatccgcactgtgcacctgcctcgcaggctgtcctgaatgtgtggctcagagcacggcc ttggaggatcccgaggaaccttgccccacatcagcctcaattccagtctttgttcttgag ggagtcacgtggaatttcactggaagggtttccatctttc >IGR1052a ggaagtggcgagctgcagacccctagtggggcccgggacggccatccgcactgtgcacct gcctcgcaggctgtcctgaatgtgtggctcagagcacggccttggaggatcccgaggaac cttgccccacatcagcctcaattccagtctttgttcttgagggagtcacgtggaatttca ctggaagggtttccatctttctggataggcagggcaatactttggctgggcagagaggac atgggtcaaagatgatgctactgggagatagatttctaggtcttgtttacaaagtcatta ccctccgtaaatatccttccagccttaaaccctaggctctggatggagaagaatgccgag accctgactcccacccacctcccctggcttccaagactctctcgtcctttgcggaagcag ccactgctcacctccagaggggaggccctcccgagggaggacatacagctcccccaaccc gaccctctgttgtttctacagagttctttcaggggctaaatcttgagtgcatgtggtgtc ttggttgtcactagcccaggtgtctgctgtggggtggtcccccgcaggtatttcctcagc aaacgtggcaggacttaataggcttggcaccagagagccggtcctgtctcctgcccggga cagcctgctggagacccagctcttgcaccatcaccctctt >IGR1053a agagttctttcaggggctaaatcttgagtgcatgtggtgtcttggttgtcactagcccag gtgtctgctgtggggtggtcccccgcaggtatttcctcagcaaacgtggcaggacttaat aggcttggcaccagagagccggtcctgtctcctgcccgggacagcctgctggagacccag ctcttgcaccatcaccctcttcacccccacagtcttctctcctctaggccaagtgtcccc tgccccctgcactgtcaggtttgccttcttccgtcgcctctccctggggaaagtgagtgg ttctggagtagctggccaccatcatcagccccctggcgaactccctgccacgtcctctgc tgttgcgtgaatgacacagccatgagcagtcgagggcggctgncttcagggacttctgag catcactgtggtgttcccatagggctctgggctccccagggagggcacctgcctgtcact acaagtttgagactggttcttgaagaccatcacccactgcaaaggcatcccatcctggag tcaccctctgccctgggcacctcccagagagtcacagtgaaaagtgttgctgacgggcat ggcctggagctgtggcttggtaaggcccgctggtctctgcactccagctgctgaccaggg ccatggggaagcaacaagagctgctgaggagtggcctagc >IGR1054a ttgaagaccatcacccactgcaaaggcatcccatcctggagtcaccctctgccctgggca cctcccagagagtcacagtgaaaagtgttgctgacgggcatggcctggagctgtggcttg gtaaggcccgctggtctctgcactccagctgctgaccagggccatggggaagcaacaaga gctgctgaggagtggcctagccagagccctgttcacagaggtggtgcgtgtgtgcaccct aatggcgagagctgtccagaaatgcaatgggctgcccctcaaatataggtagggacctgc ctgtcagtgagagggcccgaacaggttgatgacagttgtacagggggaaaaactccattc aggacaggtgacatttgganagaaataggnagggtggttaagtgtgtgggctttggagtt aaagtgaattttggaccccaatcccaactttgctcctttacctcagatgaggctctgagg ccccaggaccccagtgaggaagtagctacgtgaccttaggcaaaccgcccacgctttctg agcctcacagttctcatcggcctcctgggttgtgagggagacatggatgtgtgggtggtg ccagacacagctggccagtcctcaggagatgtgattgtgagacttcctgggtctccgtct gctcctgatgccctccttgaaccctgacagtctggcccaa >IGR1055a aagtagctacgtgaccttaggcaaaccgcccacgctttctgagcctcacagttctcatcg gcctcctgggttgtgagggagacatggatgtgtgggtggtgccagacacagctggccagt cctcaggagatgtgattgtgagacttcctgggtctccgtctgctcctgatgccctccttg aaccctgacagtctggcccaagcctctccgtccttgctggtgcagcagacagaaggtggg gcttccttcaggccatgtccccaccctcgggagctagcttgcattcagcccaggtcactg caccctaccctcgctgtaatccatcccagtcccctcctccaacccaccagcctcccgaag agctcctcagagtcttcagaccacagaccagtgtccccaaaggccaaaatgaaagacaaa tacaatcaggcctatctgtcaccaactttatttctggcttcagtttgatagtcaatgaaa caacttgttcaatgtcccctcccccagtgttcaaggtacccttctatatattaactcttt gctaacatatttaatatttaaatacnaggaaaaacaataaattactcgttggctgagagc tggctgctggctggcagacaggagcggctgttctgcccctctcctgaccctgcctcggat gaggctccgaggccccaggaccccagtgaggtagcagaat >IGR1056a tcccccagtgttcaaggtacccttctatatattaactctttgctaacatatttaatattt aaatacnaggaaaaacaataaattactcgttggctgagagctggctgctggctggcagac aggagcggctgttctgcccctctcctgaccctgcctcggatgaggctccgaggccccagg accccagtgaggtagcagaattctgtacacagtacttattaccagggactcctggngtnc actgctttagtgctgnggncctgagtctctgaacccttggctccaagtgcnagcagccac agtcttccccaatccccaacggtgacaaacacactcatttaaataacacacaataataaa taagaccaagaagaagtgtgcctgagctgctgtctgcctcagttgcctgtgtgtgaagtg ggtccctgtcccaccacatgtctggcaaggggggcanccactgtaatgctacagtgtgct ctagggcaggggaggggtgtagggacatgtcatccctgggtccaccgagctcagggccct ggacagaggaggcccaccaggctgagccctgggcaaggggaaggctgaggtcggctaggc tgaanacgggcagcacaggctgaggtctaagctaaggaattttacccctccctaaccctc cttcccgcctacccaagacatttttgacatcagaaagaaa >IGR1057a tagggacatgtcatccctgggtccaccgagctcagggccctggacagaggaggcccacca ggctgagccctgggcaaggggaaggctgaggtcggctaggctgaanacgggcagcacagg ctgaggtctaagctaaggaattttacccctccctaaccctccttcccgcctacccaagac atttttgacatcagaaagaaaaatgaatctgcaacttcaatagtcaggtcctgtctctgc aaataatgatgctttcgaagtttcagttgaacngtccctcgcgaaaaagtttctttaaat gtaagagcaggtcctttacaaactgggccacctcgattttggtgtctcgganatgcaagc tggaaaactgctgcaggacaaagaggtcagcacntgagtagaannccagaggccgggacg actcgcacaaaccaggggctttccagggactgtctcattcagtcctcacggaagtcccca tgaggtgggtactgttagtacctctactgtacagatgtggaaattgaggcccaggtagga gttaggagcccttgagcccagatcctgtaaatcccgaaggccacgtccctgctgccacaa tggccccacccctgggtgnacacacaccatggatattcagccagcttcccttcagcgagc ccagggttggcaggagggggtgcagggtgggtgtgagagg >IGR1058a acctctactgtacagatgtggaaattgaggcccaggtaggagttaggagcccttgagccc agatcctgtaaatcccgaaggccacgtccctgctgccacaatggccccacccctgggtgn acacacaccatggatattcagccagcttcccttcagcgagcccagggttggcaggagggg gtgcagggtgggtgtgagagggtgggggatgccttaccccagctgagaccctgtgcgggc agaatccgctcagcatcctctgggtcttctcgatggcactgcagcctgacacgttgatca gggattccagggctgcacagtactgtggggaggggacaccgaggggtcaggccctgcttg ggcagctgccttttgtgagtctgcaggaagatggggctgagatgcctggcgcaggtgagt ctgggtggtgggcgggaaggggccagattatggcgggagggaggagancacttgaagctt gcttggaaccccagccatggaagggaggctcagagaagataagcccaaggcctggagcct ctgccccatcctccctgcacccaaaggtccttaccatgccagctgtcaggttgatgctcc ataccatgctgccattgcagagcggancctnntgggagcaaagtgacagtgagcagagtg ctggcaggggttgtgggcctgccctggcagcccaggccag >IGR1059a gaagggaggctcagagaagataagcccaaggcctggagcctctgccccatcctccctgca cccaaaggtccttaccatgccagctgtcaggttgatgctccataccatgctgccattgca gagcggancctnntgggagcaaagtgacagtgagcagagtgctggcaggggttgtgggcc tgccctggcagcccaggccaggtctgccccagcacaggncccacaagcatccctggtgtg gcacagaggcaggcctggcancccctcancattcctgagcttcgttttctgctttgaaca gcangcataggggtgaggtcccactgtttagggtcttggagctgagagaaaaaaattgac accactagtaagggacaagctgcatgcaaggcttgccatagtcagggcaggaggacaggg gcctgcgggaagggccagggtggggacgagtgaagtaggagtggcctgggccactgttga ccaagacaaatcagatgggaggcggtggggatctggtgtattaaatgccctgccttctga tggtgagggaacactgcagttaggagcatggacactctggtgttggccaggcctggcttg aatccagcctctgtcacttaacctcactgaaccttagcagaatgggttcatcgtacctgc ctcttgaggtggctggcagtgatgaaatgacacataaagc >IGR1060a aggcggtggggatctggtgtattaaatgccctgccttctgatggtgagggaacactgcag ttaggagcatggacactctggtgttggccaggcctggcttgaatccagcctctgtcactt aacctcactgaaccttagcagaatgggttcatcgtacctgcctcttgaggtggctggcag tgatgaaatgacacataaagcacgtgcaccaggcctggtgtaagcagtgctcagacatgt gagctgttactagtggggcaaggagcggactctactaaggaatcctcctgtaagggcggg cctatgatggtgctggggagaatggctgcattgttatggtcaaaatccagttggcaaatg ccacatggttctgggagggtgctggcccttctctgctgtcctctgttcaggaatggctga gtaggagctggcagtggcagacaaggccaggccaggagagcaggtagtccctggggagtc tgccagacacctccataggtccatccacagtgctgagccccccagcccagctcctctctc cctcatggctgggccgggccttggtccatggagatttttcctgacctacaggcatcttag gaccaggcccagcctgctcatgacctcatcttgggaatcacccaccctggagccctcata gctaggaccctggctagccgacactcaccttctggttctg >IGR1061a tccatccacagtgctgagccccccagcccagctcctctctccctcatggctgggccgggc cttggtccatggagatttttcctgacctacaggcatcttaggaccaggcccagcctgctc atgacctcatcttgggaatcacccaccctggagccctcatagctaggaccctggctagcc gacactcaccttctggttctgggtgatgttgaccagctcctcaatgagctccctgagggc tgtagagggaggcacagggcctggggaggcaaagccgccaaggcaagtgagagcaatgac cgtggtcaacaaaagcgccatgaggcccagtgccaacaggagaggattgaggagcggatg cnnangctgggtggcttgtggccttggcgtcttgtggcagcttttataggcccaagtggt gacgcctgacaccatggtctctgctttttcaggcactatctagaaaccacatctttactc atcttgattttactttgtggaaaatccagtgtcgcataaaggaaagagtttgatttctca tggacttattgagaagggtccagggcagagtttccaagatctgggtgggtttaattccag cggcaggcaaggggccctgagagcggcgtggcatttgcaatgctgccctgagttccagca gttttgcctgtgacaaccctgagtacctggacagctgacc >IGR1062a gaaaatccagtgtcgcataaaggaaagagtttgatttctcatggacttattgagaagggt ccagggcagagtttccaagatctgggtgggtttaattccagcggcaggcaaggggccctg agagcggcgtggcatttgcaatgctgccctgagttccagcagttttgcctgtgacaaccc tgagtacctggacagctgacccaactctgagctcctgtcctcagacccttttgggtcacc agaagtgctgagcagatagtcttagtgcactgtggctgtgaccacagtctaccagctatg ggaatttggggagttttattttttcgatgaaccagtctcttaaattacttaagtaacact tgcttggatacaaaattcaaacaggcaatagaagagtaaagttcacttcttttggcttgc ctaattcctccttggccccactgtgagagggattgtcaaagttcagatttccaggtctcc actgagagatccagaaagattcagaggtctttctgggagcttttttggtgtttttttgtt ttgttttgttttgtttttttggagatggggtctcactatgttgcctgcctaggctggcct ccaactcccagactcaagcgatccccccacctcagcttccagagtggctggaagtagtgt gcacgtgtctggcccctttaatttaaagtgtatgggccat >IGR1063a ttcagaggtctttctgggagcttttttggtgtttttttgttttgttttgttttgtttttt tggagatggggtctcactatgttgcctgcctaggctggcctccaactcccagactcaagc gatccccccacctcagcttccagagtggctggaagtagtgtgcacgtgtctggccccttt aatttaaagtgtatgggccatccttctgggaaactcttaactgggccaggctggcagcct .
tagtccaggtcagagantgtnnrmrintnctagtgncactggggcttggggtgatcccttt gctcaccagtctctgcaggatcaacccctgccgtctgggggcctcaaatttcccttctgc agaatgagtgctgtggagggcggctcctgggcttggcccctgcagccatgtcgccttttc ctgctcttccctcnttttcctagaagtcctccagaaacccccacagcagaggccacggca tttgcctgttgggtgttgatgtcaagatttctcccctacccacttcctccccgaaccagc gcctccccaggccccctctctgcctgctcaggctccctccgtcctgtcctcgatggggct caacctcctcacaagggtgtgcttgtgaccctcctcacaaggcatgctggattcccgctc agaggcatcccaggcttgcccaccctctcttcccacaggg >IGR 1064a tgtcaagatttctcccctacccacttcctccccgaaccagcgcctccccaggccccctct ctgcctgctcaggctccctccgtcctgtcctcgatggggctcaacctcctcacaagggtg tgcttgtgaccctcctcacaaggcatgctggattcccgctcagaggcatcccaggcttgc ccaccctctcttcccacagggaacgtcattcccaccctctctgtccacactcgaagcttc ccagcccagctgctggctctgactcccagaagtctgccccttcccctcgagggcccccag tgcctggagtgccgctacttggccgtgtgaccccnctacgggcctgtttcctaatctgta gtagagggcccacggcatctcccacagggtctccgtgatgggggaaggagcggggaacta ccttggtctgtgcaactcccggagccccgcccgggtgagtcaacgccccttatcccccat ggccaccaaaagccctgccgggagcggtgggcaggggcgcccccgcgcgtgggagaaggc gctggcgcggcggttgcggcggcgatggcccgcggagataggggggtggccttatgtaac gggagatgggcccgataagcgggatctgcgcggccgggccctcctccgcggcctccggcg gtggccggtccgggaggcaggggtgggcgcgcagaccggc >IGR 1065 a gggagcggtgggcaggggcgcccccgcgcgtgggagaaggcgctggcgcggcggttgcgg cggcgatggcccgcggagataggggggtggccttatgtaacgggagatgggcccgataag cgggatctgcgcggccgggccctcctccgcggcctccggcggtggccggtccgggaggca ggggtgggcgcgcagaccggccagtctggaagctgcggaggctggcgagggggcggcaaa ggtggcggtccgagcgccaggcagggcaagggccggctggacacccgggccagcggctcc ccgagcgccggtgcgcaccggcgaggggcgggagcggccgaggggccgaggcgcgcacgt gccgctccagcaccggccatgtcaggccgagggaccccgcgggcccggccgagcggcagc ccctgccctggagggtggtctccagggaccaaggcgtggcgggcggtgcggagaggcgcg gcacagatggctacatcagagggtctgttgcttgtttctagattgtcagcggggatccac tcccgtgcgggtaattttaattaacactaactaccaaagggccgctccgggcacttggcg catgtggctcgcacctgcctgcaatgcgctgcgtgggccgcccgcttatggccatgggga gcctcttcgctttgctctggccccgaagcgctgggattgg >IGR1066a agggtctgttgcttgtttctagattgtcagcggggatccactcccgtgcgggtaatttta attaacactaactaccaaagggccgctccgggcacttggcgcatgtggctcgcacctgcc tgcaatgcgctgcgtgggccgcccgcttatggccatggggagcctcttcgctttgctctg gccccgaagcgctgggattgggacctcccttcctcccgaccagctcatcctgggaaagct ggggttgctttttcgggtttctctggactctgggtctccgttggcaaagacatgatgccc agtcaggaggagtaaggcctgagagagttgtttttgtaagtgaaaggatttaatttttta gatttttatttttaggaaagttacgaatgcagataattttaaaaatcaagaaggctgatt atgtaaaacggcagcgctgggaatccgtgctctatgggcctctggcattgctgctcctct tgtgagtgaggcacttactgccctgctgtgtcccttactgtcttttaaaggttgtttata ggccgggcgcggtggctcacgcctgtaatcccagcactttgggaggccgagatgggcgga tcacgaggtcaggagattgagaccatcctggctaacacggtgaaaccccgtctctactaa aaatacaaaaaaattagccgggcgtggtggtgggcgcctg >IGR1067a gccctgctgtgtcccttactgtcttttaaaggttgtttataggccgggcgcggtggctca cgcctgtaatcccagcactttgggaggccgagatgggcggatcacgaggtcaggagattg agaccatcctggctaacacggtgaaaccccgtctctactaaaaatacaaaaaaattagcc gggcgtggtggtgggcgcctgtagtcccagctacccaggaggctgaggcaggagaatggc gtgaacccgggaggcggagcttgcagtgagccgaaatcgcgccactgcacttaagcctgg gcgacagtgtgagactccgtcttaaaaaaaaaaaaaaaaaaaaaaaaaggttgttaagaa aatcacaaggaaggaggaaaaaatatatttcctattcattaagtggaggtggaacatcac aaaggtcttcagcgtcactgtcttcacgttgagcaggccgaggaggaagaagaggagggg tcggtcttgtcatctcaggggtggcagaggcaggagagaatccgtggataagtggatctg tgcagttcagaacctgctgttcaagggtcaactgtgtatgtaaaaaattcagtggaatct ccaccttccctcacaagtaactatttttcttaggtgttgtttttttttttttttggtatc ctattagtttatgtaaatacaagcaactgtgaatatatgg >IGR1068a ggtggcagaggcaggagagaatccgtggataagtggatctgtgcagttcagaacctgctg ttcaagggtcaactgtgtatgtaaaaaattcagtggaatctccaccttccctcacaagta actatttttcttaggtgttgtttttttttttttttggtatcctattagtttatgtaaata caagcaactgtgaatatatggtcttattttcccttgtccctacatgtgaagtggcatcat atacaccttttgcaccctgtttttctcacttactataaaaataatatatttttgtattca cacttagattgggacattttatgacttttcttctttgttctctcttattggaactgccat tttttttgactatatacctcttggacttgtcctttaattttctttttattctattttcca tttaaaaaatttctcttctctgggatattctcatagctttatcttcctgagggtatttga ttctttgtgtgtgtgtgcgcatgtgcacatgcacgctaacagcactatgttcttgtttca ttgatatcttctaagtttcctttttcatacataatctttattttctgcaagttttcttta aaaaattgttttgaactgggcgcggtggctcacccctgtaattccagcactttggggggc cgatcgcttgagcccaggagtttgacaccagcctgggaaa >IGR 1069a catgtgcacatgcacgctaacagcactatgttcttgtttcattgatatcttctaagtttc ctttttcatacataatctttattttctgcaagttttctttaaaaaattgttttgaactgg gcgcggtggctcacccctgtaattccagcactttggggggccgatcgcttgagcccagga gtttgacaccagcctgggaaacatagggagactttacttctacaaaacataaaaaaaact tagccaggcatggttgtgcatacctgtgatcccagctacttgggaggctgtgtgggagca tcacttgagctcaggagtcgaagctgcagtgagttgtgatcacaccacttcactccagcc tgggtgacagagccagaccctgcctcaaaaaaaattttttttccatcttataggctttcc ttgcacgttaggtaatcctggattgcctgcacatgttaaaacagggatctctgagggtaa ttgtgtgggagggggctgtttcctatagggcaggtggctgactgttttcacttggggaac ctcctgtggcagtttctttgtcgtttttttggcaggcaggtcagctcgcgcagaaaagat tctccctgtctccagcattccagcagcaagggtggagagagggctggggtgggggcctca gcatctgttgactgttcctgatttcagcatatttcgaccg >IGR1070a ttcctatagggcaggtggctgactgttttcacttggggaacctcctgtggcagtttcttt gtcgtttttttggcaggcaggtcagctcgcgcagaaaagattctccctgtctccagcatt ccagcagcaagggtggagagagggctggggtgggggcctcagcatctgttgactgttcct gatttcagcatatttcgaccgccctctactgtgtctagtgtttcttggtccagatatcct atccggagaaaaccctgctgcaggagagtcactcgactttgatgaacaaaaatggatatc taactgtttcttaaactgagtttcaacaactttccttattttcacccccttctcttctga tgtccttggtcttctcccagttcctgagcattcttgggattctgtaaatcaacataggtc tcagctggcctaggattcagttttcttgggtcagccaagtagtctgcccaccgtccctcc actttccacctttcaaacgctggtgctgtcatccatttctcccattttggtgggtttaaa actttagaaaattcagttactgtcattttagttggttataaagtgggagtttgtgtttat tccattgttttcatttggaatttatatttttaatgtagagaatttataaacaagacaaga aataagaggcaaacactagtcttgcaccccttttccctgg >IGR1071 a ctggtgctgtcatccatttctcccattttggtgggtttaaaactttagaaaattcagtta ctgtcattttagttggttataaagtgggagtttgtgtttattccattgttttcatttgga atttatatttttaatgtagagaatttataaacaagacaagaaataagaggcaaacactag tcttgcaccccttttccctggcactataacacctctgtatctttgctatgcacatttaca ttttgttagaaaaatgagataatacattatatagtttttactcctttttcacttaaaata tatgaagagcattctccaatgtcagtattctgcatttaaaaaaagattacacaaaatgtt attgtgtaaagtacagatatgcaaaaaaataaaaagccccatagtcccagcatccagaga taataatcattgtaatattttggtatctgtcatgctagtatgtggatatgtacagggtaa gtaccttattcctaaaataaaagggaaataactttttttctttttctttttttttttttt gagacagagccttgctctgtcacctacgttggagtgcagtggcaccatcttggctcactg caacctctgcctctcaggcacaagcaatcctcccacctcagcctcctgagtagctgagac tacaggtgagccaccacacctggctaatttttgtattttt >IGR1072a aaagggaaataactttttttctttttcttttttttttttttgagacagagccttgctctg tcacctacgttggagtgcagtggcaccatcttggctcactgcaacctctgcctctcaggc acaagcaatcctcccacctcagcctcctgagtagctgagactacaggtgagccaccacac ctggctaatttttgtattttttgtagagaccaggtttcaccatgttgcccaggctggtct catactcttgggctcaagcaatttgcctgccttggactcctgaagtgctaggattacagg tgtgagccactgtgcctggctgacatattttatttacttattagtattttttttgagatg gggtctcactctgacacccaggctgaggagcaatggtgcaaacacggctcactgcagtct caaacccctgggttcaagtgatcctcccacctcagcttcctgcgtagctgggactacagg gcaccatcatgcccacacacattggctgatttttaatttttttttgtagagatagggtta aacctttagacttaccacggttttactaataccagatcaaagaggtgcaagataaatgtt tgccttttattgcttgtctcttttataaattctctgcattaaaaatataaattccaagta aaaacaatggaatgaacataaactcccacttcataaccac >IGR1073a cattggctgatttttaatttttttttgtagagatagggttaaacctttagacttaccacg gttttactaataccagatcaaagaggtgcaagataaatgtttgccttttattgcttgtct cttttataaattctctgcattaaaaatataaattccaagtaaaaacaatggaatgaacat aaactcccacttcataaccactcaaaccatagtagcaacaaccttatcctgttgcccagg ttggtcttgaactcctgtgctcaagtgatcctcttatcttggcctcccagtgtgctggaa tcacaggcatcagccactgcacctggcctattacttaatctaatacatttctgcgccaag ccccggaagacaaataattacaaataattcccataacaatgataagttcatacattcatt aagtaaatgtttattgagtgcttactgtgtaggtgctaaacaaaacagcacagtctctgc cctcttagagatacattctagtgggtagagataatgaacaaacacatgatatatagtatg ttagaccgtgaaaagtacagtggagagggaaaaaaaagagggcaggtagaatgagtgagt acactattatatatgggatggtgacgtaaggcatcactgagaaggtgttatttgagcaga gacctgaaggatgagaggaagtggccatgcagatatttgg >IGR1074a agtgggtagagataatgaacaaacacatgatatatagtatgttagaccgtgaaaagtaca gtggagagggaaaaaaaagagggcaggtagaatgagtgagtacactattatatatgggat ggtgacgtaaggcatcactgagaaggtgttatttgagcagagacctgaaggatgagagga agtggccatgcagatatttgggggaagaaatttccaagctgaaggcacaagtaagtgcaa aggcccttttcttattttgttcatgctgctgtaacagaacacctaagactgagtaattta taaataataaaaatttattgcttacagttctggaggttgggaaatccaagatcaaggctc cagcagaattcgtgtctggtgagggctgctctctgctcccaagatggtgccttcttgctg tgtcctcatgtggtagaagagccaaagggaagaactttctccctcaagcccttttatgag gtcatgaatcccattcctccatggcctaatcaccttttaagtgccccacttcttaatagc atcaccttggggattaagttccaatgtatgaattttggagggaa acatacactcaaacca tagtagcaccaaagcaggaaaatgcccactgtgctgagaattagcaaggaaagccagaag gagtgaggggaggcatgggagaagatactgtcagagaagt >IGR1075a catggcctaatcaccttttaagtgccccacttcttaatagcatcaccttggggattaagt tccaatgtatgaattttggagggaaacatacactcaaaccatagtagcaccaaagcagga aaatgcccactgtgctgagaattagcaaggaaagccagaaggagtgaggggaggcatggg agaagatactgtcagagaagtatgtccagagcatatggagacttgtaagccattgagagg actgaggatttcatgatgagtgacatagggagccactggaggttttgagcagaggagtga catgactcaatttaccttttttctttttttaaaaaaatttgaattaacgttatatttacg gaaaagatacaaaaatagtacagacagtttccatatcccctccacttacccagcttctcc caatggtaacacattacataatcatagtgcaatgatcaaaaacagaaaaatgagcatgga tttattaagtaaactggatcctattctaatctcaccagtgtttccattcacatccttttt cagtttcaagatcaacccaggatctcacagtgcattgagttaattctctttggtctcctg cagtctgaatggttcctcagtcttgtctttcataacgcttacattttccaggaatactga tgagttatgctgtcaaatgttcctcagtttggtccccttg >IGR 1076a cctattctaatctcaccagtgtttccattcacatcctttttcagtttcaagatcaaccca ggatctcacagtgcattgagttaattctctttggtctcctgcagtctgaatggttcctca gtcttgtctttcataacgcttacattttccaggaatactgatgagttatgctgtcaaatg ttcctcagtttggtccccttggtgttttctcctaattgcactgaggttctacattttcac agagatgaagttggggccttctcactgcatcaggtcacagggttcatgaggtacatgcct tcttattggtgatgttgaccctgaccacttggttaagatggtttctgtcaggttcttcca tgataaaattactatctttccctttttagttaatatattgggaaagatagtttgagatta tataaattttttctcagatttgtgcctactaatattagcttcatcagtgactcttgtctg aaatgatttttattgtggtatttgcctagtgatgacttttctttttccctttccttctac atttattacttgtaattctactataaagaagtgctgtccttgtccctcattttttttaaa gtaagtacttgtgtatagccacataagttcatgaatatttattttactctatcggttata atccaatactgtctttattttgtttctcaaattgttctac >IGR1077a atttgcctagtgatgacttttctttttccctttccttctacatttattacttgtaattct actataaagaagtgctgtccttgtccctcattttttttaaagtaagtacttgtgtatagc cacataagttcatgaatatttattttactctatcggttataatccaatactgtctttatt ttgtttctcaaattgttctacctttgatcattgggagttacttcaggttgggttctgtgt tctttgaacaaactctacctttttttttaaaaaaaatattttcttaatttctggcaccac aaaaaattctagggtcattttgtattttccttgcctcagccctgaagtcaaccacttcac caaggagccagagttctttttattgaagagcgtgttttaaaatcgagatcttggaagtag gtgtcctcattattactggggtgtcatcacactgggccctctttaaataactttgttact ttcactataagttttcattattttcttagtggttaccctggggattacaaatgaacacct taatttagatgaatgtcaacttaatttccatttcaaaagttcctatatagctctgttgcc tctctcttttgtagcattattgtcatataaattatatttttatacattataagcccatca acagtgttaaaattcttaatgcagttccctttcaatcatg >IGR 1078 a attttcttagtggttaccctggggattacaaatgaacaccttaatttagatgaatgtcaa cttaatttccatttcaaaagttcctatatagctctgttgcctctctcttttgtagcatta ttgtcatataaattatatttttatacattataagcccatcaacagtgttaaaattcttaa tgcagttccctttcaatcatgtaggaaaagagttacaacccaaaatactttttttttttt tttgagaccgagttttgctcttgtcaccaaggctggagtgcagtggcgtgatctcagctc accgcaacctccgcctcctgggttcaagagattctcctgcctcagcctcctgagtagctg ggattacaggcgcccaccacaacgcctggctgattttttgtatttttagtagagacaggg tttcaccatgttgggcaggctggtctcaaactcctgacctcaggtgatccgcccacctcg gcctctcaaagtgttgggattacaggcatgagccactgctcccagcccccaaaatacatt tatacttttatattacctatatatttacctttaccagtactctttatttgagtattcatg agcatttgagtctagtttcattttaccctaaaggattcattctccttttatatttcttgt agggcaagtctggtgaagacagattatcacaatgtttgtt >IGR 1079a ttacaggcatgagccactgctcccagcccccaaaatacatttatacttttatattaccta tatatttacctttaccagtactctttatttgagtattcatgagcatttgagtctagtttc attttaccctaaaggattcattctccttttatatttcttgtagggcaagtctggtgaaga cagattatcacaatgtttgtttatatgggagtgtcttcatttcttgtttttgaaggacag tttttctggatacagaattcttgattgaggctgggcacagtagcccacaccttaatccca gcactttgggaggccaaggtgggaggactgcttaagactaggagtttaagaccagcctgg gcaagacagcaagaccccctgtctcttaaaaaatttttttttttgagtgtggtggcacat gctggtagtcctatttgagaggctgaggaaagagaattgcttgagcccaggagtttgaag ctacagtgagctatgattgcaccactgcaaaaataattcttggttgatagtctttttcat tcagcactttgaatatgtcatctcactgctttcaggcctgcattgtttcttaagagaagt cacttcttagctttacttgcttctttcgtttgagatctctttttcaacaatttgaccatg atgcatctaaatgtgaatccctttgagtttaccctacttg >IGR1080a caccactgcaaaaataattcttggttgatagtctttttcattcagcactttgaatatgtc atctcactgctttcaggcctgcattgtttcttaagagaagtcacttcttagctttacttg cttctttcgtttgagatctctttttcaacaatttgaccatgatgcatctaaatgtgaatc cctttgagtttaccctacttggagtttgttcaatttcttggatacgaagattaatgtttt cataaaatttgggaagttttgggctactatttcttcaaatagtctttctgctcctttctc tctctctctcttctgggattctcattatgattggtatacttggcattttggtacacttga tagtgtctcaaaggtctctgaagctctcttcatttttcttcattcttctgtctattcctc agactgtataatctcaattgaccggtctttgaactcactgattctttcttctgccagttc aaatttgctgttgacccccatctagtgaatttttatttccattactgtatttctcaactc cagaatatctatttgattcttttttataatgtttgtctccttactgatagtcctgataat ttggtgaaacatcattctcataatttcctttaattctttagactttgtttctgttagttc cttgaacatgtttataatagctgatatctaaagtctttgc >IGR1081a atctagtgaatttttatttccattactgtatttctcaactccagaatatctatttgattc ttttttataatgtttgtctccttactgatagtcctgataatttggtgaaacatcattctc ataatttcctttaattctttagactttgtttctgttagttccttgaacatgtttataata gctgatatctaaagtctttgcctagtaagtctaacatctgggcttcctcatagattgttt ctattgactgttttttaaattgctgtttatggcatgggtcagatgttcctgttctttgtg tgtcttgttttaaatactctatcaattattgaagtcagattacctactctccagggcttg cacctgttactatttcttattgttgctgctgttggtttgttctgtgtctttcctggacta attctgcaaattctatatgctttgtcatgtttggttcctgaagtctctactcagcctagt gggtaagcgaataattggacagatatttctttctaatgccttgaaccaataaattttcta gcttttgtcaagtgtgtgcatgtgtgtgtatttgtggagtcatgtcattgatgtgtcagc agacagtttacaactgcctttatcttcatttctggcatgaattgagtttcaaggtcagtc agagatgagagcttaggaccctctcaggacatgcatacat >IGR1082a cagatatttctttctaatgccttgaaccaataaattttctagcttttgtcaagtgtgtgc atgtgtgtgtatttgtggagtcatgtcattgatgtgtcagcagacagtttacaactgcct ttatcttcatttctggcatgaattgagtttcaaggtcagtcagagatgagagcttaggac cctctcaggacatgcatacatccctgcacatgcacatggacttctagattcccaggaata tgcttgagcttgtcaaagctcccgtggacatcttcttcccagatttttccttttaagttt cttggtcagccttttgttagctccacctggtaacgctgcctcaggcagccacagggttaa tcagttgccactgattattctgcaggaagggctgttttcagagtgagctctgagttaagt caaataaagataggtcctgaaaatggagcttttcagtgagttgccagacaagacaaatag aggcagttctctagtagtggagatctgggggacctccaaatctattctgtctcctccagt ggctactaggttgctgattttcacagatactaagagggctgttggttttcaagttaccat ggattaagagagaagggcatgggattagggcaacttaaaatgccactttctgctctgaga ttcagctgttttcctttaataaacacacctcagtttgtcg >IGR1083a gagatctgggggacctccaaatctattctgtctcctccagtggctactaggttgctgatt ttcacagatactaagagggctgttggttttcaagttaccatggattaagagagaagggca tgggattagggcaacttaaaatgccactttctgctctgagattcagctgttttcctttaa taaacacacctcagtttgtcgctatccattagttaatttccaaagttctgaaaaagttga ttttgacatttttgccagtcttattgcttttatgaagaagcagattttggatggctttta ctccacccttatggaagtagaaatcctttagatattaaaattataaatttgtacagatcc tttggattcaatcaacaccaaggggttctttttatggcctcctttcctgatatgcaaaca cctttttccaacagtgagaaactcagttcgtattatctacaacacaggtatgtatttgtt tgactttagtatgtacataaaaatttcgaaattgctaacccacacccctgtgagaaacac attttcttgagttactttttaaaaagatcactggctgctgtgttgagaactacagggagc aggccccaaatcagtgggagcagttacgtggttactcagattattcaggttagagatggc agtggcttggaccagagcaatgatggtttagatcaggggt >IGR1084a aaaatttcgaaattgctaacccacacccctgtgagaaacacattttcttgagttactttt taaaaagatcactggctgctgtgttgagaactacagggagcaggccccaaatcagtggga gcagttacgtggttactcagattattcaggttagagatggcagtggcttggaccagagca atgatggtttagatcaggggtccccaacccccgggctgcagaccattacctgtcctcagc ctgttaggaacagagtcgcacaacaggaggtgagtgacaggtgagggagcattaccgcct gagctctacctcctatcagattggtggtggcattagattctcacgggagtgcaaactcta ttgtgaatttgcacgtgagggatctaggttgcgtgctccttatgagaatctgactaatgc ctgatgatctgagatggaacagtttcatcccgaaaccatccccctcaccccacccgtcca tggaaaaattgtcttccactaaatcggtctctggtgccaaaatggttggggactgctggt ttaaatggtgaggcatggtcagattccggatgttttgaaaattgaacccatagtattaaa ctgacgaattagatataagatgtaagataaagaatcaaggataatgccaatttttgcctg agcaattggaataatggagttgccattaacagaagagatt >IGR1085a taaatcggtctctggtgccaaaatggttggggactgctggtttaaatggtgaggcatggt cagattccggatgttttgaaaattgaacccatagtattaaactgacgaattagatataag atgtaagataaagaatcaaggataatgccaatttttgcctgagcaattggaataatggag ttgccattaacagaagagattcaagttctgggagaaagactggttttggtcattttaagt tttagacgtttattagatattcaagtgcagatagatgcccagttatccacaggcagctga atatatcagtcaagcatttaggagagatctggattggacacaaacatttatgagttatca gtgtatagatggtggttgtaggagtggtcagtgccctgcctatatcctatgatcctagga actgccagtgtgctcctgccaactttcagctgctgctgcttttttttttttttttttttt gtctttttagacagggtctcactctgccacccacccaggctggggtgcagtggcacaaat cacagctcactgcagccttgaaccctcagactccagggatcctatctcagccaagtagct gagactacaggtgtgcaccaccatgccttgctaattttttaaaaattttatgtaaagatg ggatgtcactatgttgctcagactttctttttaaactgtg >IGR1086a cactctgccacccacccaggctggggtgcagtggcacaaatcacagctcactgcagcctt gaaccctcagactccagggatcctatctcagccaagtagctgagactacaggtgtgcacc accatgccttgctaattttttaaaaattttatgtaaagatgggatgtcactatgttgctc agactttctttttaaactgtggaaagcagctgtgtcggtacacatggcaagccagtaact aacatgtgctagaatagccttcactcagtaaccctggcaagttgttatataaatactcca ggtctcttgccccttaggtgggataattctgaggtatatattttgccaaactccccagag tctccctggggcaccaaactctaattgcccacttaccgtagctggcttaatagtaaactt ttcattggctgctttctctttcatacacaatttccccaatttcctactgattactttcac gtgaagcattgttttacgctctgcttctgggagaacccaaactaagataatttaaagcta tgagactggatgagatcaccaaataagtgagcacagagaagaaaagaggtgcagactctg agtactaaaacctgtgacattgaggggccagggaaatgaggaggaaacagcaaaggaaac gggatgtgcaggtgttgcagggaggaggcagagctggatt >IGR1087a tctgcttctgggagaacccaaactaagataatttaaagctatgagactggatgagatcac caaataagtgagcacagagaagaaaagaggtgcagactctgagtactaaaacctgtgaca ttgaggggccagggaaatgaggaggaaacagcaaaggaaacgggatgtgcaggtgttgca gggaggaggcagagctggattccagtagggctggggattgtcgggacagtttgagtacaa tgcagtggagggtgacataatgatgagccatggaatttaagttgaataaggagagaagta caggcatcagggaaacaacctgtgaaaaagccatagaatcaatggattgaaatctcagtg gggtcaaagaattgctggggttgaggaccacaggaaaattgtagacaccatggggttatt ggagagtgagatgcttaaaactgagattttggaggggtgcagttattgttattaaaagga cggggctctagaataagaccatagaactgagtatcttctcactggaggaaacaaaaaggg gctgagggaggccaaggtaggcagatcacttgaggccagacgttcaagaccagcctggcc aacaaggcgaaaccctgtctctactaaaatacaaaaattagcctggtgtggtggtacatg cctgtaatcctagctacttgggaggctgaggcaggaggat >IGR1088a catagaactgagtatcttctcactggaggaaacaaaaaggggctgagggaggccaaggta ggcagatcacttgaggccagacgttcaagaccagcctggccaacaaggcgaaaccctgtc tctactaaaatacaaaaattagcctggtgtggtggtacatgcctgtaatcctagctactt gggaggctgaggcaggaggattgcttgtatcagggaggcagaggttgcagtgagctgaga tggtgccattgcactccagcctgggtgacagagcaagactccacctcaaaaaataaaaaa gactgagaggccaaggagttgtattagaccatcacttggatattgaaatcagcaatgatt attagtaatggggtgacactgaaccgggagctaaactcttcaacaaataagagggagtga ccaagctgggaatgaaagataactgcaacaagagtgaaatgaagacagctttttcttgaa cacttacacagtatttagtaggtggcaagcagttctaagcagtttgtaaataatgtcatt caatcttcataacaaccctacaaaatatgtaccattttacccacttttacatataaggaa acagaaaacaggacaaataacttgctcaaggtccccagctagtgagtggtgtgctaggat ttgagcccaggcagtctggctcattctaacctccatccat >IGR1089a aggtggcaagcagttctaagcagtttgtaaataatgtcattcaatcttcataacaaccct acaaaatatgtaccattttacccacttttacatataaggaaacagaaaacaggacaaata acttgctcaaggtccccagctagtgagtggtgtgctaggatttgagcccaggcagtctgg ctcattctaacctccatccatgctgtgatggctattcattccaatgtggggaagggggat atttggagactgatctagaagcagcaatgagaagccagaaaggcacctatcccacctcca aacccatgggcttcttggaatgaaagcagccactctcagaagtgctgccaaggatgccac atattcagggggaaaccagatttaaaattgggaagtctgttttaacttgcaaatgatact tttgtttcactgcctatattgatcgtgtattgcctttgttattctttgctgcaacaacta gcactttcattaacatgttgatagaaggtaactggctttaatatttactgagaaatgttt tattttgcagttaagatgactgtttaattttgatttagcaacagataacattaagaaaat attatttgcaaaactgtgagtttgctaaagctaggagatgttgaattttatcaaatatag ctgctaganttttttcagaatttttttcaccttcggtttt >IGR1090a gatagaaggtaactggctttaatatttactgagaaatgttttattttgcagttaagatga ctgtttaattttgatttagcaacagataacattaagaaaatattatttgcaaaactgtga gtttgctaaagctaggagatgttgaattttatcaaatatagctgctaganttttttcaga atttttttcaccttcggttttattatagtgatggatttatcaacagatttttcattttct gaaatcttgcattcttgggataaaaatatcttggttattgtggatgtttaatatatgact agaattgatttgctcttaatcttactcgtgattacatttaggacccccccccaccccacc accacccccaggatactctgtcttaaggtccttagctttaatcacatctgcaaagtttcc tttgctgtataaagtaacagtcacgggttctagaaatcaggacctgtctatctttggggg ccaaccatttaacctagcacagatagatgccttaggaccttagggcttaattctcttctg gacccagttgagaaaagctgtctaggcaaacatgctcattatagctacagatggcacaaa accatgccatgtgactgaatcaagacccggtatggtcctggctgactctgaatgacaaaa ctctacaaagcataattcaaaagcgtgtgacttggttgca >IGR1091a cagatagatgccttaggaccttagggcttaattctcttctggacccagttgagaaaagct gtctaggcaaacatgctcattatagctacagatggcacaaaaccatgccatgtgactgaa tcaagacccggtatggtcctggctgactctgaatgacaaaactctacaaagcataattca aaagcgtgtgacttggttgcattctgtgtggaatggaaggattcaagatgtcagctggca attccaggaaaaactgtgattaggcttttcttagaagtggcatctgaagagcaaatggag aggcctgttcttccaggtctggttggaccctacagggagcaggccttgactctgtgagtg agcctggcttgccttccacatggcaatgcccacttagagaggaatcaggattgatggtga agccagtatgctacacaggatagacgcagaggagtgttacaggcttcttcacgatgggca gatcaggcctcaagtggtcagagctttccaaaggtgggtgtgcacagtggagaatttcct ctctgtagagagagctctgagtctggatgaccatctggaagggatatgtaggagaagaag gtggtgggtactgacttagatgattacttaaggttcctgtcaaactttgagaccccattc aactacttcaaattttagttggggaaaccaagtcccagag >IGR1092a agagctttccaaaggtgggtgtgcacagtggagaatttcctctctgtagagagagctctg agtctggatgaccatctggaagggatatgtaggagaagaaggtggtgggtactgacttag atgattacttaaggttcctgtcaaactttgagaccccattcaactacttcaaattttagt tggggaaaccaagtcccagagagagaggtcactggatttataaagttaaaagcagagcca aacatacatctcaccatttctggtcatcctcagatattaatactcagtttttcaaaccac atgcaaggaagtaaattcagaggtaacatttaactatgatttaaaaaaataccaaaacca taaattttcaaggcagtaattatctccttctcaacagtgctttgagaagaagcatgcatt tgcactggggagggaggcacagagtcgagtctcggctgtactgctgaaccctgaaggcct gacagaggctgcctggaatgggatgaagagcagcaaatcagaaacaggcaatctgtccaa ttttcagtgaaacaagtttcatgattttagaacctctcaacatccaaaatcctagacaca atgttcctttgaaagaatatattttcttattgactaagttgatatgagaaataagtttct tattatacactttctgaggacctacatttctatggcattt >IGR1093a gggatgaagagcagcaaatcagaaacaggcaatctgtccaattttcagtgaaacaagttt catgattttagaacctctcaacatccaaaatcctagacacaatgttcctttgaaagaata tattttcttattgactaagttgatatgagaaataagtttcttattatacactttctgagg acctacatttctatggcatttaaatcttggatatttttaatgaacattgaatcccaggga gctaacactgcatttcacaatctctgagcactgatcgatgttctttttaatcctgtagaa tttctccacatattcagaacgtcctaaaagctccacaaaatcttcatcatgagtgattac cagaagctggaagttacgctgctgtgagcgactttttattatcctgcaacaatatattca gaacatattattagtaaagagcataaccccttctttgatttgaaaagtcaccgcaaacct tgtcagacacatgaacttgtgctgtgtgtcagggccccagctaccctgcaggaagtggag gggtggccccaggccttcaggccagccaggcaggagtctcttctcctctccagacagtag ggacacatggcctgactcctcacttaggtctggcttagggactcacaggaatacaagaac tagtttcttccagatcagaagttctcactaaagcaggtat >IGR1094a tgctgtgtgtcagggccccagctaccctgcaggaagtggaggggtggccccaggccttca ggccagccaggcaggagtctcttctcctctccagacagtagggacacatggcctgactcc tcacttaggtctggcttagggactcacaggaatacaagaactagtttcttccagatcaga agttctcactaaagcaggtataaatattttattgagttttccttaatatccaaactgttc aactatagaaggcttactccttcgcctgggattttcctgacctgttactacttttctctg gaagaaaaatttaaaagtaataaagacaaactacaggtaaggggaataacactgctttct taagagctgggtctacttagaattctgccaccaccagtcactagatgcatcattactatg acacacagggacctgagtgggtgttctgggaacattttgctgaggtaaccagcaatgtga ctgaaacctgaaagactttttcttttagctagccacttatccccttcctggagctggatg catttgaggtttcaaaagcactcgcccttacttgtgatgatggctgcagaaaggtggccc tgcgctgctgagctctccttctggccctctctgccagaaagggactgtctggagccagga gtgcctgaaacacctcctttgacctcagggaaactgcctt >IGR1095a ttcttttagctagccacttatccccttcctggagctggatgcatttgaggtttcaaaagc actcgcccttacttgtgatgatggctgcagaaaggtggccctgcgctgctgagctctcct tctggccctctctgccagaaagggactgtctggagccaggagtgcctgaaacacctcctt tgacctcagggaaactgcctttttctctgccagcatagtccttatgcaagagctgcttga caaccttggcgtctacactgaccccaggtgaatgtggtaaaaggtgtgcaattttaccct cactggactttacctaatctcaaataagctttttgagtaagagctctgtcattcctcaca gttctctgacacatgtggaaagctggggagacagtcctaaacccactaccactacctgca gatgtcttagcagggcatgctaattgctgtgcatgacatgtgggttcctctggtaggttt acaggaaaaccaggccaggaacccctcacagtgactctctccctgtgaacacacttgggg agctgcaggatgtgtctggggctgctgttcaccatctagttcctttaggagggatctgaa gaattactatcaaaaggtaaagcccagggcctggcaccaactggcttccccaagaagtgg ggaacacagctagagaacgttttcatcacagaactctctt >IGR1096a aacccctcacagtgactctctccctgtgaacacacttggggagctgcaggatgtgtctgg ggctgctgttcaccatctagttcctttaggagggatctgaagaattactatcaaaaggta aagcccagggcctggcaccaactggcttccccaagaagtggggaacacagctagagaacg ttttcatcacagaactctcttggttttgaagaactatcacaacctgtccccaaatgtgag atacttactcaaccagagcatgtgcaagagatacttactcaaccagagcatgtgcaagag attcaatgttttctcggtcaagatttgttgttggctcatccaaggcaatgatgccacagt tgaggcagaacgtttcagccagggccaggcgaatgatgagtgaggctaatacctggaaaa aagcccctatgtgagaagcccagcacagaccttctcatctcatggcaggcaagcagtcct gacatgatcttttcagcagggaaaagtgggaaacgtcacaggttcactgttaggtaaagc actgccctctgggagagcccagcactgggaccagattcttatgtcctccagaaggagaac ctgcatgatctcagcctatcattcaccacaaaacaaaatgctcagaacaacgctgatgct ctcacataaaaaattacatcagctacaaccaacttgagac >IGR1097a ggaaaagtgggaaacgtcacaggttcactgttaggtaaagcactgccctctgggagagcc cagcactgggaccagattcttatgtcctccagaaggagaacctgcatgatctcagcctat cattcaccacaaaacaaaatgctcagaacaacgctgatgctctcacataaaaaattacat cagctacaaccaacttgagaccaaaggctagaaacagagacaatgccatttatctgtaat tttaataatcctgtaagatgagcaaccttaaaaattcttgacctggctatttgcctgata atgggatctgttagaaaacttcgacacgttttctagagcctctcactttttctctgctac ctttaaatttccatattcttgtgtataatcctgagactgagagaataaaaaagaaaatcc taggtcaaagtatcaggagtatagaaatgtggtttcagttaagcttacctgtagaaaatc caagtaactggaactgttaggcattttcgtggttactagaaacctaatactaaaaccctc agacccactgaaaccatctgaggatacaagacacacagaattgagagagtagggctattc taggaagtataaactactctggtgtgagctgtaagtcccctttccccctcagtttgtggg tgggtgcgcacacatcagtgagttggtaattttagaatag >IGR1098a ggcattttcgtggttactagaaacctaatactaaaaccctcagacccactgaaaccatct gaggatacaagacacacagaattgagagagtagggctattctaggaagtataaactactc tggtgtgagctgtaagtcccctttccccctcagtttgtgggtgggtgcgcacacatcagt gagttggtaattttagaatagtttatgtcttttctttaatgcctaggcaagccagaagac agggccacagcttggccctgtgagggacaggcatttccttcctgtctttgaatccaaact gctgtcaactctaccaccacccactcacatgcagagcccctggctggctgctagagcctc agcaaaagccagtgttaggtaggctggaggcccacctccattatttgttctctcccctca caccaaggagacaattattgctaattaattttcataactcagaatagctacaaaaaatct ttttcctcaagatatttttgaaagtatttttaattcaaagagaccatgtttcaaactctg tattttctcatttataattaccactaaaaatcatcaaagcacgtagggatactgattaca gatcacaagtttgtcatttttgtagactatgatttagacagtaatctgcagatgctttaa attgggatcagctgtctaggctgacaacataatacatata >IGR 1099a gaaagtatttttaattcaaagagaccatgtttcaaactctgtattttctcatttataatt accactaaaaatcatcaaagcacgtagggatactgattacagatcacaagtttgtcattt ttgtagactatgatttagacagtaatctgcagatgctttaaattgggatcagctgtctag gctgacaacataatacatatatgcatggcatgttcttttttttttttttttttgagacgg agtttcgctcttgttgcctgggctggagtgcaatggcacgatctcggctcactgcaacct ccgcctcccaggttcaagcaattctcctgcctcagcctcccgagtagctgggattacagg cacatgctaccatgcccagctaatttttgtatttttaatagagacggagtttcaccatgt taggctggtctcgaactcctgacctcaggtgatctgcccgcctcggccttccaaagtgct gcgattacaggtgtgagacaccatgcccagctgcatggcatgttctttaagcaaaaactg caaactatgaaaatgagttagataatgtaagcatctatttctatgattttagaattttat ttaaaaaaagtcaagggcctagaggtgttatcaagtgtaatcttctgccttgatctgaaa gcagaaagctcaagtatctgtgacatctttgttacaaacc >IGR1100a accatgcccagctgcatggcatgttctttaagcaaaaactgcaaactatgaaaatgagtt agataatgtaagcatctatttctatgattttagaattttatttaaaaaaagtcaagggcc tagaggtgttatcaagtgtaatcttctgccttgatctgaaagcagaaagctcaagtatct gtgacatctttgttacaaacctgtgcacagtgaaggatccagccttgttccccaaggatg ccatattcctgattctttaaaacttcattcctcttcctgatttccaatgtaggctgtcct cacagagccttacctgaagccagatggcctgacccagcagctaagtctttgtgtatgctg tggtagggacttagttctatgaggggctactttcttaatgagactccttactatactgga atattcattctagcttaagctagaatctggtttgcaatactattatgtcattgattctga aacatcttatggttataattgcattttttcattcctgctggcacataaaatagtggtatg tcttataactgatgagacagtgaccttattctgataaggagtgccatgaaaactctaacg ggtcttcagcttcttgttctacatttagcctatcctgtgagaatgcttcaggcccttctt ttaaaagtctacataatgttgcaggaaatgttggttagct >IGR1101a tgcattttttcattcctgctggcacataaaatagtggtatgtcttataactgatgagaca gtgaccttattctgataaggagtgccatgaaaactctaacgggtcttcagcttcttgttc tacatttagcctatcctgtgagaatgcttcaggcccttcttttaaaagtctacataatgt tgcaggaaatgttggttagcttcaggagagtgtaataatagtagctgagcctgattcatt ttatatagcagcaaagagcttcccaccattcaggtgtagccttgggtgcttccactgcac tgatgtttgtttctctctttcagttacttgggtgagttggctccccaggcttttgagata cctgccttttgtccagcactgcatcgtcctcgcatatccaaggctgtgtctcccttcagc atcaccactcggtagttataattccgccttttatcagaagctgatacattttcatcggca tcagaccgtatttctatgtattcaatatctgacacaggaagaagaatattttagaggaac ctatgctctgtagccttttgtcatttacaaacatatcaagtaagcctaggaacaacagat gaggctgacattaccagaggaaaacaatggctggtgtggaaactctttctctggctggga ggattcaagagcctggtggtctggccagaagcaacccaga >IGR1102a attcaatatctgacacaggaagaagaatattttagaggaacctatgctctgtagcctttt gtcatttacaaacatatcaagtaagcctaggaacaacagatgaggctgacattaccagag gaaaacaatggctggtgtggaaactctttctctggctgggaggattcaagagcctggtgg tctggccagaagcaacccagatgccccagttcctcagcctcaactctttcttagtttccc tgttaagagtttcctccaggccaggcgcggtggctcacgcctgtaaacccaacactggga ggccaaggtgggcagatcacctgagggcaggagtttgagaccagcctggccaacatggtg aaaccccatctctactaagaatacaaaaaattagccaggtgtgggagcgcgcacctgtaa ttccagctactactcgggaggctgaggtgggagaatcacctgaacccaggaggtggaggt tgcagtgagccaagattgcaccactgcgctccagcccgggtgacagagaagtgcgagact ccatctggaaaaaaaaaaaagaaaaagaaaaaaaaaagagtttcctctggatggtttttc ttattgcattttggcttatccctatctacactatgacagaacctattatgtcatcagcta aatataatgcctactgcagtcaaatatgtaagtcctgtta >IGR1103a accactgcgctccagcccgggtgacagagaagtgcgagactccatctggaaaaaaaaaaa agaaaaagaaaaaaaaaagagtttcctctggatggtttttcttattgcattttggcttat ccctatctacactatgacagaacctattatgtcatcagctaaatataatgcctactgcag tcaaatatgtaagtcctgttaggctctggaacagaaaactttacattttcttgctacaag atgttgccaagataagaattcttagaaaatctcaaagacatgcttagaaaggggtccagg gaggtaatgctggcatgatgagaggtcataaggggaagagctgcggagagggctttggaa agagcatttgtgatacaccatggtactcaccttgtccacgataggtacttcgccacaggt cacgtataattttattgatttcttccattttcatactgtgaaatttcattattgctctgg aaaaggaagtcattggtacttcatatatataaaaaataattatgtgtaatagtaatatta aaatacataaaatatataatatataaaaaatagaaatataaataacttcctcaatatttt caatggtaaaagtagaatatagtaagagctacaaaaataaacagcagcaaaactttgctg cttggctaatactgaaaattggcaggcttatttctagtgc >IGR1104a ttcatatatataaaaaataattatgtgtaatagtaatattaaaatacataaaatatataa tatataaaaaatagaaatataaataacttcctcaatattttcaatggtaaaagtagaata tagtaagagctacaaaaataaacagcagcaaaactttgctgcttggctaatactgaaaat tggcaggcttatttctagtgctccaggggtacccttctccatattcactctctaggatac aacaaatactcctttacgtaaatacttaaatactgtgaaaacttcaggaaacataatttt ttagacttttttcttaggccgtggtaacttattggagggaatgcttccactgatactcac gggtcacaggaaggcctgctgaatggacgacagggagttaaagggtagaaggtttacggt tagccaaggggcctgcagtctatggggaaaataggagaatcgaactgccaccttgtccct cttctatcactgttaaggcttaccaaaagtcagcttcttatgttggttttattcctcaga tcttagatttttaccaactggaagctttggttcagcgagaatgatttagaagcttaagct gaactgacatcaaaattttattttacctttccttcacagattcagaaatcctaattctaa atattaacttccatatttatattccaaatcctaactctaa >IGR 1 l OS a ttaccaaaagtcagcttcttatgttggttttattcctcagatcttagatttttaccaact ggaagctttggttcagcgagaatgatttagaagcttaagctgaactgacatcaaaatttt attttacctttccttcacagattcagaaatcctaattctaaatattaacttccatattta tattccaaatcctaactctaagcactaaattccacttagtccagacatgtccctgtcctc aactctcttttaaggtagtagtttctaaacactaaaaacaaagaggagaaatgtttgtaa aagcaaaagtagcctgtcaaaacctaacattgttcccaccacagtcacctttcatcaaaa agcccttaggttctttggaagcgggtttatgaactaataaatgttgcaccagtggtaaaa aggcaaacattactgcgatcatcatacaaaggatgtgaggatgtgaggcgacttacttcc atttgcaggcctcttatctgatgcatacaaaaaaagaaactgaatataatgctactgcct ctgtagaatcatttcgtgatcttctggttcaccagcaagagagaaagaaatgactcaaca taaatacattttaaatatcagatgaaggactgtgaagtagtagaagactggaaaaaacca tattctgcttgttgatgagaatgcaacaagtctccatttt >IGR1106a gatgcatacaaaaaaagaaactgaatataatgctactgcctctgtagaatcatttcgtga tcttctggttcaccagcaagagagaaagaaatgactcaacataaatacattttaaatatc agatgaaggactgtgaagtagtagaagactggaaaaaaccatattctgcttgttgatgag aatgcaacaagtctccattttctaccttatacatttatctcagcctaacattttatgctc ctttcaaaaggagacaaaacatctaagtatttcctaaaaacaaaacaaaactgatggaat gttagaccaatcatgtaaagactgcctttccatagcttatatatcatgatcctgattttt caaatgacattaaaaaaaagttatctttccattcaagttaaaaatcttcaaaaactaaca taagcattctaatgtggagaacaagctccagacaaggcaggggtggccaaggcgcacacg tgcagtctgccttggctcccttatacaacacaggtggtgcatcctgtcccatggccaggt ctgctgagacacagcactgcgggaaaaagatctagttcagggagaggtctcaacccacca aagagtgtgtcggatggagttgatgactaccactgtgggacggaccattaactcatcttc gtatcctctctgtctactatggaatttacagctgtactgt >IGR1107a cttatacaacacaggtggtgcatcctgtcccatggccaggtctgctgagacacagcactg cgggaaaaagatctagttcagggagaggtctcaacccaccaaagagtgtgtcggatggag ttgatgactaccactgtgggacggaccattaactcatcttcgtatcctctctgtctacta tggaatttacagctgtactgtgtaagagatggggatgactaaggtcgctacagtaatcta cataagggaataacaatgataataatgattattattgatgaccatttaccatatgcgaga caaaactatgctaaataatcaatttcatttaatccttacgacaatactgggaattagata ctgttatctctatttaccattaacaaaactaagattcaatgaaatcagtgacttgttcaa gatcagagaaaagtggctaggatattaacagcccttgaatatgacagttaaaattgaaaa ggcagtcaaaattccatcttttaaagccaccagactcagttttatgagggaatgttatca aatcttcaagacacacctagctcccaagtatataaggtatgacacagcaaggagaaacat aaggggaaaaaagtacaaggctatttttcttatgaatataaacattctaaataaaacgaa atttagtagtaagggtagtaaaaagaatatatcatgacca >IGR1108a tttaaagccaccagactcagttttatgagggaatgttatcaaatcttcaagacacaccta gctcccaagtatataaggtatgacacagcaaggagaaacataaggggaaaaaagtacaag gctatttttcttatgaatataaacattctaaataaaacgaaatttagtagtaagggtagt aaaaagaatatatcatgaccaagtagtgtttacaacaagaaagaaacagtaaaactgggg aaaataattcaactaatatagtagcagattaaaaagaaaaaaataatttttcaatagatg tcataaaaacatttgatacactgtaacactgaattttgataaaatatcttaagtgaaaaa tcaaagaatgttttcttaactggacaaaatgactccctcagatatccacagcaagcatca aatttaatttaaaatctatagaagtgttcctcctaaaactaagaagagaaagatgcctcc tattatggctgctctaaaataaggtcctggaaatccctaacgattcagggatttcacgat tcaaatccctacctaaaaagaaatgagaaatgaaaaaaagagagaaaagcctgtcattat ttttgcaggtgacagaattgtatgcttagaaaatccaagaaaatcaactgaaaaattatt cagactaatgagatagccagagataaatatataaaaatga , >IGR1109a taaggtcctggaaatccctaacgattcagggatttcacgattcaaatccctacctaaaaa gaaatgagaaatgaaaaaaagagagaaaagcctgtcattatttttgcaggtgacagaatt gtatgcttagaaaatccaagaaaatcaactgaaaaattattcagactaatgagatagcca gagataaatatataaaaatgaagttttattatctagaggcaaacaccaataggaaaggca atagaaaaaaaaaggatcctattcacagtggcgataaaaaccctaaaatgcctaggaata agtctaacaaaagggtataggagctagaggaaaaagctgtaaaactttacaataggataa aaggaaatgattgagcaggagatgcatactaaggagtccagaatggtagatgtgatatta caaagatgtccgttctcctcaaataatccataaattaaatgcaatccaaacagaaacccc aataaaattaaaaaatgcttaacagaatccataagctgactctaaagttcatatagaaga gataatacaaaagaaaaaaaataaattttaaaagttggtatacaaaggaaaatccagaaa caaacccaaatgcatatagaacgttagtttataactgcaacagttcaaatcaactggaaa gttttcaacagtgttacaaaagataaaaaaaaaattatta >IGR 111 Oa taacagaatccataagctgactctaaagttcatatagaagagataatacaaaagaaaaaa aataaattttaaaagttggtatacaaaggaaaatccagaaacaaacccaaatgcatatag aacgttagtttataactgcaacagttcaaatcaactggaaagttttcaacagtgttacaa aagataaaaaaaaaattattacccgttatccaacctcaaaataaaatccaaatgaatgaa aggattaaaagctaaagtatttgggcagctgaggtgggaggattgcttgagcctggagtt tgagaccagcctgggcaacatagtgagatcccatctctacaaaaaaatttaaaaattagc tgggtgtggtggtgagtgcctgtagtcccagctacttgggaggctgaggtgagaggatca actgagcccgggaagttgaagctacagtaagctgtgatcatgccactgcactccagcctc ggtgacagagtaagaccctgtctgaaaaaacaaaaaacaaaaaacaaaagctaaggtaaa ataaaacaatcagatgaaaacattttgataattttaggattgggaagcctttctaaataa ggaacaaaattgagaagccataaatcaaaagactaaagatttgactacctaaaaattaaa agttacaaaagataccataaagaaagctgaggcagctggg >IGRlllla gtctgaaaaaacaaaaaacaaaaaacaaaagctaaggtaaaataaaacaatcagatgaaa acattttgataattttaggattgggaagcctttctaaataaggaacaaaattgagaagcc ataaatcaaaagactaaagatttgactacctaaaaattaaaagttacaaaagataccata aagaaagctgaggcagctgggtgcggtggctcacacctgtaatcccaacactttaggagg ccaaggcaggcagatcacttgaggtcaggagtttgagaccagcctgaccaacatggtgta accctgtctctactaaagatacaagaattagccaggcgtggtggtacatgcctgtagtcc cagctactcgggaggctgaggcaggagaatcgcttcaacccgggagatggaggcggaagg aagtaagctgagattgtgccactgcactccagcctggacgacagagctagactctgtctc aaaaaaaaaaaaaaaaaaaagaaaaaacgaaagaaaattgatggacaaacgataaactgg gaataggtacttgcaatgtatgtgaaaataattaacatctagaatctattaaaatgtgac aaatcaagaaacagacaacctagtagaaaaactggcaaagagatatgaataggtaattct tggagaagaaatacaaatagacaacatacaaaaagacatt >IGR1112a agaaaaaacgaaagaaaattgatggacaaacgataaactgggaataggtacttgcaatgt atgtgaaaataattaacatctagaatctattaaaatgtgacaaatcaagaaacagacaac ctagtagaaaaactggcaaagagatatgaataggtaattcttggagaagaaatacaaata gacaacatacaaaaagacatttaacttcactagtaaagagggaaatgtaaattaaagtgc aagctttttttgtgcagccaataaaatgtcagtaacaaaatccagacatggaatgggcac tttcatatactattggtggaaattttctaagtgtttttagaaggcaatttggcattaact aaaaaatatacataacatctgagccagtaactccatttctaggaagctgtctttttgaca tatctgctttagtgtgcaaagacacactctgcagcattatctgtagtagcacatatttaa aagctttctaatatgttcaatagtggttaaataaagtagatatcatgcattttacagaat atgcagccattaaaaatacaaggtacttgaatatatgaacgtaaaagattatcaccacgt taaatggaaaaaaaaactcagaaaaatatctaccttgtgataatgcttacaaagaacaaa aaagatgtatttgggtgtactatgtgcaaagccattgtga >IGR1113a atagtggttaaataaagtagatatcatgcattttacagaatatgcagccattaaaaatac aaggtacttgaatatatgaacgtaaaagattatcaccacgttaaatggaaaaaaaaactc agaaaaatatctaccttgtgataatgcttacaaagaacaaaaaagatgtatttgggtgta ctatgtgcaaagccattgtgagggaaatgaaaatatgtcaccaacttaataattcttaag ggctgaatcaaagttagacactgtcatggaaatgagcctaagtctaccttgaagtgtgtt ctgtggtttgcagttatggagcgtggggaagcccaaatatctgtaatacaaggctgaatg gctttagttgtataagtggtacaaaatattattaagtacaaaggtaggaaaaaaatcaca tatgtttgggaagggcttaatcaacataacattccaaggatgggagagatagcacaggaa aatatgggacaaaattgtttggttagaacacacttggtagtaggaattgaaatgggaaag cccaggtatggaagtcattcctaaaattagaagggaatagggaccaccagctttaggaaa atgaagctggcagaagtataatgggtggaggtgggggtaggaaggacggtaagagataag aggtgggaaaggtgccacggtaataggtgagagttactta >IGR1114a tggttagaacacacttggtagtaggaattgaaatgggaaagcccaggtatggaagtcatt cctaaaattagaagggaatagggaccaccagctttaggaaaatgaagctggcagaagtat aatgggtggaggtgggggtaggaaggacggtaagagataagaggtgggaaaggtgccacg gtaataggtgagagttacttaggctgaagccatggaaagaaggcagctctgggctgggtg cggtggctcacacctgcaatcccagcactttgggaagctaaggtgggaggatagcttgat cccaggaagtcaaggctgcagtgagctgtgatcatagcactgcactccagcctgggtgac agagtgagatcctgtacaagaaccctataggagctattgagtgacatatagtggcccaat taacttaacacgcttttatcacttggactttacaggcatttaacatcaaataacttacag aatgaccttgaaagtccatgactgtctggtgaggcaaagatttgaatttcatgggctgca aactgttatggtcaagtagccatctggctagtgtatcagctccaccacctgcctggagta tgcacatctctcagttaaatgcatatactaactcatgcgaagtagtatgatttctttgtg aaaactggctcttaaagtgagaggccaggtgaggtggctc >IGRl 115a gactgtctggtgaggcaaagatttgaatttcatgggctgcaaactgttatggtcaagtag ccatctggctagtgtatcagctccaccacctgcctggagtatgcacatctctcagttaaa tgcatatactaactcatgcgaagtagtatgatttctttgtgaaaactggctcttaaagtg agaggccaggtgaggtggctcacgcctgtaatcccagcactttgggaggccaaggtgggt aaatcacttgaggtcagatgttagagaccaccctggccaacatggtaaaactctatctct actaaaaatacaaaaattagccggtgtggtggtgggcacctgtaatcccagctatttggg aggctgaggcaggaggatcgcttgaacctgggaggtggaggttacagtgagccgagtttg caagaatgaactccagcctgggtgacagagccagactctgtcttaaaaaaaaaaaaaaaa aaaagtgagactctctcggagctcagaaaataatgatttataaattactttagtctgata tttaaatactcattaagagtctgaaagatttcattaaaaatttcagtaacaatcgattgc attttatgaggaaaaatgatggctttaatggcatttatatttctggtaatccatgaaagt cttaacaagcttgtccagcctgccttattttgttgttctg >IGR1116a agctcagaaaataatgatttataaattactttagtctgatatttaaatactcattaagag tctgaaagatttcattaaaaatttcagtaacaatcgattgcattttatgaggaaaaatga tggctttaatggcatttatatttctggtaatccatgaaagtcttaacaagcttgtccagc ctgccttattttgttgttctgttttgttctaggcttttagcagactgaagccatggtttt tagttttgtctctagtgatgagcagaaaagagggatgaggaagaggctttactggtccaa ccagaaagagaagctaagaacccatgactggattctctcccttggacaccccacagacca atatctcaccttccaggagaagacccttccagctcttgcttctttaaacctattaactta gttttctttagctagactcccaaacatcagcttttacaattcagcctatggttcaatcac tatggcaagataaacatttgtttaggtgtgaaacaccactggctatctttgggttttgta atctaccctcttgaggttgcaggagctactgtgaaaccttactgcatccatggtcatgat agagatggtgactctaaggtgagccctgaataaagccctcatctgaagctcccctcgaat gcagggacccaggctctgaagagcctcacagaaagctggc >IGR1117a gtttaggtgtgaaacaccactggctatctttgggttttgtaatctaccctcttgaggttg caggagctactgtgaaaccttactgcatccatggtcatgatagagatggtgactctaagg tgagccctgaataaagccctcatctgaagctcccctcgaatgcagggacccaggctctga agagcctcacagaaagctggctaccttggatgcaaaactgtaaaggttacgtgtttacaa tgagtcttaaaagaagcatgacctggccaggtgcgtggctcatgcttgtaatcccagcac tttgggaggccaaggcaggtggatcacaaggtcaagagatcaagaccatcctggccaaca tggtgaaaccccgtctctactaaaaatacaaaaaattagccgggtgtggtggcaggcgcc tgtaatcccagctacttgggaggccgaggcagaagaattgcttgaacccgggaggtggag atggcagtgagctgagatcgcaccattggagtccagcctgggcaaaaagagcgaaactct gtctcaaaaaaaaaaaaaaaagtattacctaatatgcaaccttccacatctggggaaaaa tgagagtagaacattttgggcatggggtagaacaccatatcttgagtgatatattctaac atcatttaaattggtatattgtattagtatggggtaatac >IGR1118a gcaccattggagtccagcctgggcaaaaagagcgaaactctgtctcaaaaaaaaaaaaaa aagtattacctaatatgcaaccttccacatctggggaaaaatgagagtagaacattttgg gcatggggtagaacaccatatcttgagtgatatattctaacatcatttaaattggtatat tgtattagtatggggtaatacattccaaatgatggataatttcccccttttcatctatgt gtctctgaccactgccaatgcttatacttagtgatgtttttagatgattactaataacag atggtaatcagcttttcttgaaaatgcactgctgacttcctgtgttaccttaaatagaca gctgaacgcaacaattacactgactgcatgctttattctaagacgtgaaagaatgaggga aattttgtaccttactttcttctgggtgagaaggcaaatttagggctcaccgtataaatc ttgagaaggccactgtttgcgagcataagccacaaagactcaattttggggaaatttgta tcacctcttttcatttagaagaatccatctgagtaccaggtaagagaactcagtaaacag cctggctttgttccttaacaagcctaaattgctagaaagcactcctgtacctctccaccc cgccaggctccaccaagctccctcataggtcctcattctg >IGR1119a cgagcataagccacaaagactcaattttggggaaatttgtatcacctcttttcatttaga agaatccatctgagtaccaggtaagagaactcagtaaacagcctggctttgttccttaac aagcctaaattgctagaaagcactcctgtacctctccaccccgccaggctccaccaagct ccctcataggtcctcattctgctcagcatgcctctgtgactgaggcacttttctctgctg aaaagcccttccttcttatcccaggcccaggtcaaaaacagactatggagcacctaccaa ggtctccatcagacagactgtcagcagtttggaggagggacagggaaagatattcctgtt ttcccagagcctgacaagaaagtggcagagcaagggttgttgaattcttttttatttttt ctcttatagcctaatcttggaagtgaagggaattcttattcctgctgccactggttctca gggtatgcagggatagctggagagctcctacgtatgtttttctattcagtgaatacatat gaaaccccaggtctgcaggtcaatgggctgtaagagaagagctgaccttgcagcaaaata cttacaagtaaaattgaaaacaaaaccaacctgcctatttaacttggtccctggtccact ctaaccattgccccatttttcttgctccccgtcacaggag >IGRl 120a gagagctcctacgtatgtttttctattcagtgaatacatatgaaaccccaggtctgcagg tcaatgggctgtaagagaagagctgaccttgcagcaaaatacttacaagtaaaattgaaa acaaaaccaacctgcctatttaacttggtccctggtccactctaaccattgccccatttt tcttgctccccgtcacaggagaagttgttataagaattatctatattctctgtctccatt tctttttcttttttttttctgagacagtttttttctcttgttgcccaggctggagtacaa tggcacgatcttggctcactgcaacctccgcctcccgggttcaggcgattctcctgcctc agcctcctgagtagctgggattacaggctaggcaccaccaggcccagctaatttttgcat ttttagtagagacgtggtttccccatgttggtcaggctggtctcgaactcctgacttcag gtgatccacccgccctggcctcccaaagtgctgggattacaggtgtgagccaccgtgccc ggctgctgtctccatttcttactacccattctctccccacccaacttgaccgggcttcag ttccaactgtgccactgactgctcctcagtcattaacaacttccattttgtcaaatttaa gggccacttcttagtccttatcttatttgactccaaatag >IGR1121a ctcccaaagtgctgggattacaggtgtgagccaccgtgcccggctgctgtctccatttct tactacccattctctccccacccaacttgaccgggcttcagttccaactgtgccactgac tgctcctcagtcattaacaacttccattttgtcaaatttaagggccacttcttagtcctt atcttatttgactccaaatagcattagattcttgatatatttgcttcacttggttttcaa gataccacatcttttaaaatcttttcccacatcaccagctgcttatttactggatttgca aacataactagtggtgggacctttcccttctctctctatgctcattccacatgtgatctc atctcatgggttaaatgccgtggatatgctgatgactccccagtgtacacctttcacttg aactctaggctcgaggttatatatccaactgcctgcttgacagctctgcttagatatcta caggcacttcaaacttaaagtgtacaaaacggaactactgattttctctccccagtccca cccattttagggaatggcaacctgttctcccaatatcctgttgttcaagcaaaaatatgt aggagcaacctttggttattttactttccctcccttacactcaattcagaagcaaggcct gtcaactctctctccagaacaaatcccaagtctatcactt >IGR1122a gtgtacaaaacggaactactgattttctctccccagtcccacccattttagggaatggca acctgttctcccaatatcctgttgttcaagcaaaaatatgtaggagcaacctttggttat tttactttccctcccttacactcaattcagaagcaaggcctgtcaactctctctccagaa caaatcccaagtctatcacttctctccattttcactgctaccacctgatctagcccacca ccatctcttggttactacaagtctcctcatcagtctctgcttttactcttgccctttaca atccattctccacacccagcagccagtgcaatttcttccaactagaaatcagattatatt acttccctgcttcaaaccctccagtgactgcccaatgcagttagaatgaaataaaactgt ttgtttaccaaggctacaaggcatgacatactctgggaatggtctatccctgactatatt ccacccatgcttgccttcttcctggtccttgaacactttctgttcgtactggtcttggct gctgcagtaactattctctctacctggaacgcctgcaccccattttttgcatatcttgct cccttctcatcaatcaggtcccagcttaaaggcccatctgttatgctcacattgttcatt ttcactgtaatacctaccactactacccattttgttatta >IGR1123a tcctggtccttgaacactttctgttcgtactggtcttggctgctgcagtaactattctct ctacctggaacgcctgcaccccattttttgcatatcttgctcccttctcatcaatcaggt cccagcttaaaggcccatctgttatgctcacattgttcattttcactgtaatacctacca ctactacccattttgttattaatttatttcttaattttgtttcttcatccttatatactt agtatctagaacagtatcaagcatttatgtactcaaatttttattgaacaaaatcctaat atacaactatgtattatgtacacaagcacctcactgaagagttacaaaatatatagaaat aagttatggttctaaaccaggaagtataagtaacagttaaaatgcttttatataaatact agttttttaacggttataaaaaaaggtcatgcccgtaatcccagcactttgggaggctga ggagggtggatcacttgaggccaggagttcaaaactagcctggtcatcatggcgaaacct cgtttctactaaaaatacaaaaattagcccagtgtggtagcacatgcctgtaatcccagc tacttagaaggctgaggcatgagaatcgcttgaacccaagaggcagaggttacagtgagc agagatcacgccactgcactccagcctgagagagctgaga >IGR1124a gccaggagttcaaaactagcctggtcatcatggcgaaacctcgtttctactaaaaataca aaaattagcccagtgtggtagcacatgcctgtaatcccagctacttagaaggctgaggca tgagaatcgcttgaacccaagaggcagaggttacagtgagcagagatcacgccactgcac tccagcctgagagagctgagagaaccagtgagactccgtctccagaaaaataaaaaaaaa agcagggggccactatggtagcagcatgtcacagtggttctgatatctaattttatctct accatttacctgggtaatcttgggtagcctgcttaatctgtctgataaatacttgccctt taaaacagagttagatacaataattaaatcgattatgctatcatgtagtattcaattgct attattgtcttctatgcacagccctcaacctcaaagaatgtttaaatgggaacagaaacc tacgttttcttaatgaatttagttctttagtgctattaaagaatagagaatttaagaact taacttacattaaagaatggaacatgacaaaggaagctggactaaatcgcctctgagctt ttctgactctatactgaataatagtatagatttttaaaaattctattttatagatgagga aacggaaactcagagtgtctaaataatttgctaaatatct >IGR 1125 a tagttctttagtgctattaaagaatagagaatttaagaacttaacttacattaaagaatg gaacatgacaaaggaagctggactaaatcgcctctgagcttttctgactctatactgaat aatagtatagatttttaaaaattctattttatagatgaggaaacggaaactcagagtgtc taaataatttgctaaatatcttcagtcaggactcaaaatcaccactatggagaatagtat ggaggttcctaaaaaaactaaagacagaactaccatatgattctgcaatcccacttactg gatatttacgcaaaggaaatgaaatcattaggttgaggagatatctgcactcccatattt attgcagcactgttcataatacctaagatttggaagcaacctaagtgtccatcaacagat aaatggataaagaaaatgtggttcctctcgggcgcggtggctcacgtctaattccagcac tgtgggaggctgaggcgggtggatcatttgaggtcaggagttcgagatcaatatggccta catggcaaaaccctgtttctactaaaaatacaaaaattagccaggtgtggtggcaggaac ctgtaattccagctactcggaggctgaggtggaggttgcagtgagctgaaatcacaccac tgcacttcagcctgggagacagagactccgtctcaaaaaa >IGR1126a tggatcatttgaggtcaggagttcgagatcaatatggcctacatggcaaaaccctgtttc tactaaaaatacaaaaattagccaggtgtggtggcaggaacctgtaattccagctactcg gaggctgaggtggaggttgcagtgagctgaaatcacaccactgcacttcagcctgggaga cagagactccgtctcaaaaaaaaaaaaaagttgttcatatatacaatggagtgctattca gccataaaataaaatgagatcctgtcatctggaataacatggatggaactgaaggacatt atgttaggtgaaataagccaggcacagaaagacaaactttgcatgttctcattcatttgt gggagtgaaaaattaaaacaattgaactcatggagatagtggagatgatagttaccagag actaggaagggcagtggagatggttaacaagtacaaaaatatagtaagaataagatctag tatattatagcacaacagagtgactacagtcaacaatgtattgtacatttaaaaataact aaatagtataattggaatgtctgtaacaaaaggaaggataaatgcttgaggtgatggaaa cctcatttaccctgatgtgattattatgcattgtatgcctgcatcaaaatatctcacgta ccacataaatataccggctatatagccataaaaaataaga >IGRl 127a gtgactacagtcaacaatgtattgtacatttaaaaataactaaatagtataattggaatg tctgtaacaaaaggaaggataaatgcttgaggtgatggaaacctcatttaccctgatgtg attattatgcattgtatgcctgcatcaaaatatctcacgtaccacataaatataccggct atatagccataaaaaataagaataaaactttttttaaaaaaaagaattcggccgggcgcg gtggctcacgcctgtaatcccagcactttgggaggccgaggcgggcggatcacgaggtca ggagatcgagaccatcccggctaaaacggtgaaaccccgtctctactaaaaatacaaaaa attagccgggcgtagtggcgggcgcctgtagtcccagctacttgggaggctgaggcagga gaatggcgtgaacccgggaggcggagcttgcagtgagccgagatcccgccactgcactcc agcctgggcgacagagcgagactccgtctcaaaaaaaaaaaaaaagaattcaaaatctgg acatctgtagtgttcagagacagcacttttaaccatgtattatggacttctgaggctttt taaaaaaggtaaaacttatcatgttggacttttatacaaagtccaatgtcttgcttttaa tatccatttttatttttccatcacaaccaacttatcttat >IGR1128a gactccgtctcaaaaaaaaaaaaaaagaattcaaaatctggacatctgtagtgttcagag acagcacttttaaccatgtattatggacttctgaggctttttaaaaaaggtaaaacttat catgttggacttttatacaaagtccaatgtcttgcttttaatatccatttttatttttcc atcacaaccaacttatcttattccaaatagaagttttggtgatttttttttttttttttt ttttgagacagggtctctttctgtcacccacgctggagtgcactggcacaatcttggctc attgcaacccgccacgggcttctgagtagctgggattacaggtgtgtgctaccacgccca gataatttttgtatttttttgtagtgatggggtttcgccatgttgcccaggttggtctca aactcctggacttaagcaatccacccactttggactcccaaagtgctaggattacaggcg taagccactaagcctggcaaaataggtttttaccaacaaaaatctgttttgatttgtgtc tcttcaaataaactataatatccttgctagaagttactggatctcctattccttaatgct caatgaatgtttgataagtctattagatacacagcatctgttgttaaagaactaagaaaa actaaaaagtcccctaaaggcataaatgaggtagctgaga >IGR1129a aaataggtttttaccaacaaaaatctgttttgatttgtgtctcttcaaataaactataat atccttgctagaagttactggatctcctattccttaatgctcaatgaatgtttgataagt ctattagatacacagcatctgttgttaaagaactaagaaaaactaaaaagtcccctaaag gcataaatgaggtagctgagaagactaaaaagaattattaaaggcaaaaaaaaccaaaaa acaaaaaacaaatatatgtatgtgtagtctactgggcaagaattccttaagttttgctta tgttcttgtttcagcaccttaaattccaagactaaccactttaaactgctggatctaata tctaggagagatggcaatattcaaagaagttaaaaaacaaaagttctcatttggtgcagg catataattctatgagccattttggacccagggaacattgtaatgttaacgtacccactc acaatgaaatgggacaaaagatatatccatggaatactctcaaaaaattgttttaaaagt taaacttaatctaacaaaaatcttagtataatttatttttaaaaaataacatgttaattg gctcactcccaatatttcacagtaaatggatctaatttgtcttacatgattacgtacttc ctaaaacttgtatatgccaaaaatatgcctaggcaattct >IGR1130a gatatatccatggaatactctcaaaaaattgttttaaaagttaaacttaatctaacaaaa atcttagtataatttatttttaaaaaataacatgttaattggctcactcccaatatttca cagtaaatggatctaatttgtcttacatgattacgtacttcctaaaacttgtatatgcca aaaatatgcctaggcaattctgggaccacctttgttatcatcactaactaaaaaagtcct catactgaaaccagagttctcctgtcttcctgagccctgtggtctgaatgccactgctca ggttggtctgttgactatgctgtatctgaccagaagtcttagaagagaagctctctgtgt aactctcttagtgctaaggaagatatttgccattctggaaaaaacaaccaccaccaaaat ctaaggtaagtaataattctcctgccacaaatgaacagaactactagatagacttataac aaaacttattttaaattcatagttgagctcacaagaaagaaagggaaatccctacataat agaaacgaagatagaagtgaaaaccagaccagtcagtatgtaacctgacagacaaactaa acttggggttattattattactgttattgttagttttgagacagagtctcgttctgttgc ccaggctggagtgcagtggtgcaatcttggctcactgcaa >IGR1131a tagttgagctcacaagaaagaaagggaaatccctacataatagaaacgaagatagaagtg aaaaccagaccagtcagtatgtaacctgacagacaaactaaacttggggttattattatt actgttattgttagttttgagacagagtctcgttctgttgcccaggctggagtgcagtgg tgcaatcttggctcactgcaacctctacttcccagttcaagcgattctcctgcctcagcc tcctgagtagctggcattacaggtgtgcaccactacagccagctaatttttgtatttttt ttagtacagacggggtttcaccatgttggccaggctggtcttgaactcctcacctcaagt gatccgcccacctcggtctcccaaagtgctgggcttacaggcatgagccaccgtgcccag ccatgaacttggcgttattgtttttataacctagggattggttcttatcatccaggacag aagatgaaggataggacccaagtaaggaagaagattagaagtgactcccaacacacaaaa aatgggactcttcaagagctataacatcaatcctcaatgaaagagtggaaaattaatgag ttgaaaattcaaagtcttgggcaaatgctttatatagttttggggttcaaagttatgcta ccagtgagtatagtctaggaacctaccaactaagaaatta >IGR1132a aagtaaggaagaagattagaagtgactcccaacacacaaaaaatgggactcttcaagagc tataacatcaatcctcaatgaaagagtggaaaattaatgagttgaaaattcaaagtcttg ggcaaatgctttatatagttttggggttcaaagttatgctaccagtgagtatagtctagg aacctaccaactaagaaattaacaaaaaccctacatgcaggccaatgttttctctggagc tcttagttaatataaaaccaaaatttctgtgtagatggacctctacaaggaaaggtcaca agggagtctcatagaaaaaacaacactactaaagataagcacacaattaaatgttaataa aacacagaaacttcactaggggatagaatcaacatacaaaacagcagaagcagactcctc aaaatgtgaaattaaaaaataacaatctgaaagagaatataaaatgtgtatagttaaaat gagtaaagacacattcaagaaggaatcaaaatactaaggaagaaaatacatcataagcct ggcacagtggctcacatctgtaatcctagcactttgggaggcctaggtataaaatgtgta taaaatgagtaaagacacattcaagaaggaatcaaaatacaaaggaagaaaatacatcat aggcctggcgcagtggctcgcatctgtaatcctagcattt >IGR1133a aaggaatcaaaatactaaggaagaaaatacatcataagcctggcacagtggctcacatct gtaatcctagcactttgggaggcctaggtataaaatgtgtataaaatgagtaaagacaca ttcaagaaggaatcaaaatacaaaggaagaaaatacatcataggcctggcgcagtggctc gcatctgtaatcctagcattttgggagacctaggcaggaggatcgcttgaggccaggagt tcaagaccagccggggcaacatgacaaaaccccatctgtaataaaaatacaaaaattagc cgagtggtggcatgcatctgtaattccagctatctgggaggctgaggaatgagaactgct tgaactcaggaggtggaggctgcagtgagccgagatcatgccactgcactctagcctggg cgacagagccagactctgttttaaaaaaaaaaaattataaaaaaaccatgtgagtttctg aaaaagaacaaaatagaacttatagaaaaaaatggaggaaaaaatgacaactcaataggc agtataagtagcagctaaataatttatttaacaagatatttacccagagcccagtatatg caagaggggttaagcaatgtagaggaaagaggaggttatgtctaataaaaagtgaagaag gggaaaatagtgagaaatggagaaagaataatatttgaag >IGR1134a ttatagaaaaaaatggaggaaaaaatgacaactcaataggcagtataagtagcagctaaa taatttatttaacaagatatttacccagagcccagtatatgcaagaggggttaagcaatg tagaggaaagaggaggttatgtctaataaaaagtgaagaaggggaaaatagtgagaaatg gagaaagaataatatttgaagagataatgtatgaaaaatccccaaaattgatggaagata tcaatcctcagatcaaaaagcataatttatgagcagaagaactaaagctgagtctagaca cactattataaaaatacagaacactgaagacaaagggaaaaatcctaagagaaccagggg aaaaaggcagattacttttaaaggaataattaaaatgatttctcaactgtaaccatagag gccaacaaaaaatgaaatattttcaaagtgccaagagaacaaaactgtcaatctagaact ctatgctcagctaaactatcaaattaaggggaaaaacttctcaaagactgattgtttacc actaacagtcattcactgaaaaaactattgaagaatatactccaaaaaaagaaaactgaa cctaaagaagggaggagtgggatttaaaaagcaagaatgaacaaagaaattgggaaacat gcgggcttatgaaaccaccacaataattattactcatttg >IGR1135a caaattaaggggaaaaacttctcaaagactgattgtttaccactaacagtcattcactga aaaaactattgaagaatatactccaaaaaaagaaaactgaacctaaagaagggaggagtg ggatttaaaaagcaagaatgaacaaagaaattgggaaacatgcgggcttatgaaaccacc acaataattattactcatttgtgatgatttaaaaacaaggtaaaactaaaatattagaca aaagaaataatgcagatgagagaagataattagtattcaggaaaaagataaaacaattca cattaaagctatggtttttaaactttgatgtgcatcagaatcacccaaaatgtctgtcaa aaatagactgctgggccctacctctcaaatttttgatcgaggtctggggtagaagctgag aggcatttctaacatgttccaaggtgatactgataatggtgctccacgaccactttgaga actaatgcatatgattttaagtcaaataagtatttaaaaattaaaaagtaaacactcaaa taactaaagtagaatacaaccgatccttgaacacaggtttgaaccatgtgggtctatgtt tatgtagattttcttccacctctgccatccgagacagcaagactgacccctcctcttctt cctcctcctcttcaatgtgaagaggacaaggatgaagacc >IGR1136a agtcaaataagtatttaaaaattaaaaagtaaacactcaaataactaaagtagaatacaa ccgatccttgaacacaggtttgaaccatgtgggtctatgtttatgtagattttcttccac ctctgccatccgagacagcaagactgacccctcctcttcttcctcctcctcttcaatgtg aagaggacaaggatgaagacctttatgatgattcatttccacttaacagaaaatatattt tcccttataattttttcttgtctccagtttactttattgtgaaagaatactgcatataat acacataacatacaaaatatatgttaatcaactgtttctgttatcagtaaggcttccagt caacagtaggctattagtagttaagttctgagggaatcaaaagttatatgtggatttctg actgcgtggggggcttagtgtccctaatccccatgttatatggtcaactggataacccaa agaagggaaaaaggaggagtcaagaaaaataaatccatctcaaaaaggcaggaaaggaaa aaaagatggcagaaataaatccaactcaattgagtaatcagaatgaatatgaaaggccta aattcactggttaaaagacagacatacactggataaagaaaattctgctatatgtaatta agatggtgagagaaatggcacagagatagacaaagtgatg >IGR1137a tcaagaaaaataaatccatctcaaaaaggcaggaaaggaaaaaaagatggcagaaataaa tccaactcaattgagtaatcagaatgaatatgaaaggcctaaattcactggttaaaagac agacatacactggataaagaaaattctgctatatgtaattaagatggtgagagaaatggc acagagatagacaaagtgatgaattaagtagaacagagaacccaggccaacccaggcaca tagggaattctgatatatgacagaaatgacactgtaggtcactgagagaaggatagtcta caataaatagagccaagacaaccagttattcataacggaaaaaattcaacttagaattaa atacttaaatgtacttacatgtgaaaggcaaaatttaaaacttttagacaaaaatataga agtagggcgtggcagctcacgcctgtaatcccagcactttgggaggccaatacaggtgga tcacgaggtcaggaaatcgagaccatcctggctaacacggtgaaaccccatctctactaa aaatgcaataaaattagccgggcgtagtggcgggcgcctgtagtcccagctactcaggag gctgaggcaggagaatggcgtgaacctgggaggcagagcttgcagtgagccgagatggcg ccactgcactccagcctgggcgactgagtgagactccgtc >IGR1138a agaccatcctggctaacacggtgaaaccccatctctactaaaaatgcaataaaattagcc gggcgtagtggcgggcgcctgtagtcccagctactcaggaggctgaggcaggagaatggc gtgaacctgggaggcagagcttgcagtgagccgagatggcgccactgcactccagcctgg gcgactgagtgagactccgtctcaaaaaaaaaaaagatatatctctctctctctctctct atatatatatatatctttatatatatatatctttatatatatatatatagagagagagag agagagagaggagtagagagagagagagagagagagagagaggagtagggaaggatttct taacaagacacacaaagagctaaccagaaaaggctgctaaattcaactaactcaaaatca aatccagtgtcatcaaaagatgctaagtaaaaaagataagcataatgtttgaaaagacat ttgtaatacatataactgaaaaggaattgaaatgcagaagagataaagaacacatttaaa tcaataagaaaagaccaatagggccaggaacaatgcctcacacctgtgaccccagcactt tgggaggccgaagtgggaggaatgcctgagcccaggagtttgaggttacactgaactatg attgcaccattgcactctagcctaggtgacaaagagagac >IGR1139a aaaggaattgaaatgcagaagagataaagaacacatttaaatcaataagaaaagaccaat agggccaggaacaatgcctcacacctgtgaccccagcactttgggaggccgaagtgggag gaatgcctgagcccaggagtttgaggttacactgaactatgattgcaccattgcactcta gcctaggtgacaaagagagactctgtcccaaaacacacaaaaagacaagactaataatgt ataaacaacgattcatcattttaaacctatgaggttggcaaacattaagaaatttataaa accaatgtcagaggatccatcaaataaacccttatatactgctagtggtataaatcagta gtcatttctggaaaacaatattattttgtaaaattgagcatactccacaatgcactccca caaatataaccttatacctttcctccagaagacatgacaagacctggaaaaaaaccccaa atgtccatctgtaggagaatgaatgcattgtggtctattcccatagtagattatgtacat cagtgaaaatgaatcaactacggccataaacaacatggataaacaaaagcaaatccaaat aaaaaagcaagtcctagaatatcatatcatttttaaaaagctcaaaatatgacatatata tgataaaactgttttttaaaaaagcagagaaagtaaaaat >IGR1140a tgaatgcattgtggtctattcccatagtagattatgtacatcagtgaaaatgaatcaact acggccataaacaacatggataaacaaaagcaaatccaaataaaaaagcaagtcctagaa tatcatatcatttttaaaaagctcaaaatatgacatatatatgataaaactgttttttaa aaaagcagagaaagtaaaaatctttgtcactggttatagggaatggggatgacagaaggt tgagataagaagggagcatctaagtggatgccaatcagtgataatggtagattggttaga gggaggtagtatcatgaatactcgtagatattaatatgctttatatcttaacttcataac ttaagctagtgtgtgtttacatacatacatacatatattttccaatccatggtatacata aaataccatatttaaagagaaaaaatgaggggctgggcgcagtggctcatgcctgtaatc ccagcactttgggaggccgaggcgggtggatcacctcaggtcaggagttcgagaccagcc tgancnacatggngaaaccnngtctctactaaaaatacaannattagcnnngcgtggtgg cangcncctgtaatnccagntacttgggaggntgaggcagnnnaatcnnttgaacccggg aggcagaggttgcagtgagcngagatngtgccattgcact >IGR1141a aggcgggtggatcacctcaggtcaggagttcgagaccagcctgancnacatggngaaacc nngtctctactaaaaatacaannattagcnnngcgtggtggcangcncctgtaatnccag ntacttgggaggntgaggcagnnnaatcnnttgaacccgggaggcagaggttgcagtgag cngagatngtgccattgcactccagcctgggnaacaanagtgaaactctgtctcaaaaaa nnntaaaannnnnaagaaaaaaagaaaaanannnnanaanngnnnannaannnannttnn nnnatntnaantgcantannnaaatccccagtctaatacttactggtcaagagtcttata ataaatatccagatccttgttcacaagttctgttgtcctcataacaatcatcatttctct atacttttcctcagcatcccgaaattgtggttctcgaagttctttcttaaaatgaataat ttcttcttcataacctttctgtcgccctaatgccaaattatgatttctttttatattgtc tatgttctcttccaacttctgatgttcactgtaaaaaagaaaaatgacaaatgaggacca ttttttagcttttaacaacctgaagtggaaaagtcatagatttctttagataggttaagt atcattctccttagcaatcagtatattataacagagtctc >IGR 1142a tgtcgccctaatgccaaattatgatttctttttatattgtctatgttctcttccaacttc tgatgttcactgtaaaaaagaaaaatgacaaatgaggaccattttttagcttttaacaac ctgaagtggaaaagtcatagatttctttagataggttaagtatcattctccttagcaatc agtatattataacagagtctctccttgcttattatttagggctttggtactaaagaaaac ccctctcttccttccatatctctgccgcacataggttgctaaatagctaattttgtgtat tacagaaccctcatagcatgtgatcactgataaagttcctggcctttagacgctaagtaa agcactctggtgattaatattacaaattcacaatcttctgattgtgaactgagaatgcac aattatcaacactaagaagttatggataacaggcttcatcatcattttgctcatgtcaaa ggcacaatacgaattaaatcatatattaattttctgcagtaatacttattaaaaatttag attcctccatgaaaacaaaatttctcttgcacaagtgtaaaaaccataataatgaccaaa aaagtaaaatattcaaacttttctgatattttggcagattatacaaatttcaatgtatgc tttaaaaatcttcatttatttattatcacttattaagcat >IGR 1143 a catatattaattttctgcagtaatacttattaaaaatttagattcctccatgaaaacaaa atttctcttgcacaagtgtaaaaaccataataatgaccaaaaaagtaaaatattcaaact tttctgatattttggcagattatacaaatttcaatgtatgctttaaaaatcttcatttat ttattatcacttattaagcatcctcttatgtgtcaggcactactctcaagcttatgggca tccttacagagtcgactggattacaagtcttgttggcatttctgttatgtcctggttgaa gaaacgtttgaaaaatagttgtacttagtaatgtgaatgaatgtaaaaagtactgttatg taccaattacagaagaaattttttaaatatctggttttggtctttagtagccacgaatat attattttatatcaaaatttcttctagaagcattacttttccaacttgccatggagagta tcgtgtaaaagaactgaggcttgggaactaggatattagggtcacattcttggctttcat cataatttcctctgtgatttttctgggtctaagtgtgcataatgcatacaaaaatgaaga ctctgaagatgatgagctcttctagttaaaaatctgatttccctgatataggaaagagat tttaaatagctaagagtacttaaccaaaacacaggattaa >IGR 1144a cttgggaactaggatattagggtcacattcttggctttcatcataatttcctctgtgatt tttctgggtctaagtgtgcataatgcatacaaaaatgaagactctgaagatgatgagctc ttctagttaaaaatctgatttccctgatataggaaagagattttaaatagctaagagtac ttaaccaaaacacaggattaaccatttgttaggctttataaattaaaattcactttacta tatcctttagaaaagcctgggcattttttcattcagatttctgtataaattcaagaagac atgaaaactctacaaggaagggtttaataaatgagaggcctggatttaaccagctgaggt ggttgacaatctaagtatttgcctagtacaaccttttataccagtctagtgccttagcat caacaaggttcttacagaattcctaaggcaactaactctaaggcagtcaaggcaggaata aaatcttttctgctgtaccaggaaggtagcaactacaataagtaacaataagaccagata aaggaagaatgaggctcatctttcaaaagaaatgctctggtggacacataattacaaatg agaaaatctaaaatgaatctctgtggataaatcactctggcaacaactccattgacaata ttatagactgtacaagctctgacccagacaaggtccacag >IGR1145a aggaaggtagcaactacaataagtaacaataagaccagataaaggaagaatgaggctcat ctttcaaaagaaatgctctggtggacacataattacaaatgagaaaatctaaaatgaatc tctgtggataaatcactctggcaacaactccattgacaatattatagactgtacaagctc tgacccagacaaggtccacagctccatattctttatgcttagtaccactattctgtgcag caggctagcagatgtatgggggctaagcatgttcaatactgaataactaaggcccatcac tacagtgtgattaccaattctatatcacttcttcagtaataaagttcttaaggccatgaa atataattgtatcaaaacactgttcaccttctagtaactctcaaaggataccaggctgag gctaaaattcttttaaaacaggtatttaatattcttcacattccagtaataaagacgttt atttaaactgaagattattttaaaagcataccttttcatttgcaaaacctgcatttgacc catttccttcaaatgttgttttctttcttcttcaacttcttttagttcctcatttctttt tcttaaagtaaggttatcttgtagccacctttcttgtatctaaaggtaaacattaaatta gttaacaaaaataaccaagttactaacatgaaatctgtaa >IGR1146a ttaaaagcataccttttcatttgcaaaacctgcatttgacccatttccttcaaatgttgt tttctttcttcttcaacttcttttagttcctcatttctttttcttaaagtaaggttatct tgtagccacctttcttgtatctaaaggtaaacattaaattagttaacaaaaataaccaag ttactaacatgaaatctgtaacaggcaactggtgacagcaagtgccatttctgtcttact tagaatcatgtgaaattcaacagagggagaataagccagtgtgaaggaatctacaggtct ggggcaatctggatggcccatccccatccacagtgacaagtgtaatacctcctgtagcgc agcttttactgctctttcacaaccataatctaaaaaccaggtctactgtttgatggggag tctcataaagatttgagcatatatctgtgtacttatttacttataaagtattaaaaacat acaaaacagacattttaaatggtgaaattaaaaatataactagatattttaatacctaca tccccagtggatcattttgcataggaaccccatgataaagcctactgacctgaaagatta taagagatcaatactactactgaagtcttccccaactttttcgtcctagttctgtctccc aacatgtaccaagaccattagaacctgttaggtatatgtt >IGR1147a tggtgaaattaaaaatataactagatattttaatacctacatccccagtggatcattttg cataggaaccccatgataaagcctactgacctgaaagattataagagatcaatactacta ctgaagtcttccccaactttttcgtcctagttctgtctcccaacatgtaccaagaccatt agaacctgttaggtatatgttacctgcaacttctacctttaggttgacaaattgtaatca ctcaaggcagtaagaagtgccacaatagtagcatatatctatgaacttggtacctcctta gccaccgaaatgaaatttcaaaaaattggctgttcttgttgagtagttttgtccttcaaa agagactcaataacacttagcagcagcagcaacaacaacaaaattatttcagtggttttc ctggtgattaaaatgaactatgttgtcaagagacaatcattagaaaacagtttttaagtt gattctttggaatttagaggaaaaaaaatttcctgcagaaagaagggtgatttggcccac aaatcatgtgtatagaaaacttattctgaatttggagtaaggatttctcaaagagggagc tgggaccctcctgcaatagcccttgcagctaagctaaactcagtgacatgggaagtgaga gagatggacagacctgtggcaatatcttgcaccaacagta >IGR1148a gaaaaaaaatttcctgcagaaagaagggtgatttggcccacaaatcatgtgtatagaaaa cttattctgaatttggagtaaggatttctcaaagagggagctgggaccctcctgcaatag cccttgcagctaagctaaactcagtgacatgggaagtgagagagatggacagacctgtgg caatatcttgcaccaacagtaaaggccagggactggtagatgagagagggaaatcaagga tttctctcacatgcttaatgttcatatccaatcctgcccctctatgcgtgactattttta gagttttttttttcttttttaacagtcacaaagtaaggctactttcatttttcctggaaa taatataaacatacaatttatccacagggtccacatctacggattcaactaaccatggat caaaaatattggggaaaaaaaataaaaagtaatagtacaataaaaaaatacaaatttaaa ataatacaatataaaaactacgtatcatttacatattaatatcaaaagcaatctagagat taaagtatatcagaggatatggataggctatatgtaaacactagatatgccattttatat aagggacttgagcatcctagatttcggtatctgttttatcgggggatcctggaaccaatc cctcccagagataccgagacaactgaatatgtatctacta >IGR1149a acgtatcatttacatattaatatcaaaagcaatctagagattaaagtatatcagaggata tggataggctatatgtaaacactagatatgccattttatataagggacttgagcatccta gatttcggtatctgttttatcgggggatcctggaaccaatccctcccagagataccgaga caactgaatatgtatctactaaaggcattattataggcagttaaaggtgactaaaatgac atggttataaatgtcctttgttgctaaagcaatctaatgtaccactgtagctggtgtgac ttaccaaggttctactatggggtactatgcttgttgttccttattaggaacaagggaatg tgctactgcttactttcatctaataccccagaacatttgaatttgttttcacaattgcat gaaaggactctttaaagtgctatcacatttttagatgagactgatttttggcacaaaata ttgttgctggtctgtctacctgcattgttaccagacagctaggcatttctttgttttagg tcagcttccattattcttctagttttgaaagacagtatataccacatcaagagtgtaatg ctttgaagtcagatacatctaggctcaaatcacagtgttattacttttaaactggataac tttgggcaaattagtttaaattctctgaacctcagtttgc >IGR1150a ctgcattgttaccagacagctaggcatttctttgttttaggtcagcttccattattcttc tagttttgaaagacagtatataccacatcaagagtgtaatgctttgaagtcagatacatc taggctcaaatcacagtgttattacttttaaactggataactttgggcaaattagtttaa attctctgaacctcagtttgcttataacatggtcaataatgatactatctatcataaaga actattgtgtggccgggcgtggtggctcatacctgtaatcccagcactttgggaggccaa ggcagatggattacttgaggtcaggagttcgagatcatcctggccaacatagtgaaaccc cacctctactaaaaatacaaaaattagccaggcctggtggcactcgcctgtagccccagg caggttgaggcaggagaatcacttgaacccgggaggcgaatgttgcagtgagccgagatt gtgccactgcactccagcctgggtgagagagcaagactccatctaatttaaaaaaaaaaa aaaaaaaaaaaagactattgtgaagattaaaggaatgagtgtatgtaatcagtatagtgc ctgactcaataattgctaataaaatgccttttgggtcaaatttgtcctttgtactgtaag cagtgagaattccaattatagtctacaaaatgtatcagag >IGR1151a tgggtgagagagcaagactccatctaatttaaaaaaaaaaaaaaaaaaaaaaagactatt g2gaagattaaaggaatgagtgtatgtaatcagtatagtgcctgactcaataattgctaa taaaatgccttttgggtcaaatttgtcctttgtactgtaagcagtgagaattccaattat agtctacaaaatgtatcagagaaaggaagggaaaaaaaatcagatgcagttatagtatac cacaaatgtttttccattctactagaaatttgatagtgtagggtccagttctacctgtta ctactttttgtgaccttggacaagtcaggtcacctacagttctcttcatatattccttca gctgaaaactgagaaaggcagttaagtttccaaattattttattctgtggactaaattta gcagggcttaaatcagtacgtaaataagtgactgttaggctcctcagctcttaaatatta accccaatcatccaactcagatgacagttaatgcatgcagctggtcacctatggaaacat aaaaattagctgcattctagatacctgtgagagagtggcatgctgaacagattacagtcc aatgtccaccaaaagtctagctgggaataacaccacttctacaagactgcctgaaagcta tgcagtccatccagtgctggctcagttattgacagctaaa >IGR1152a gatgacagttaatgcatgcagctggtcacctatggaaacataaaaattagctgcattcta gatacctgtgagagagtggcatgctgaacagattacagtccaatgtccaccaaaagtcta gctgggaataacaccacttctacaagactgcctgaaagctatgcagtccatccagtgctg gctcagttattgacagctaaagggatatattagaacctctaaggaatttcaacaaaacac acatatctctgcccaaacccccaagattctgatttactggtgtggattggagacatagac atatatatatatatattttttgagacagggtcttgctctgttgcccaggctggagtgcag tggcgtagtaagggctcactgcagccttgaactccccagctcaagcaatcctcccacctc agcctcctgagtagctgggactacaggtatgcaccatcacacctggctaatttttttgta gagatggggtttcgccatattgcccaggatagtctggaactcccaggctcaagcaatctg cccgcctcggcctcccaaagtgctaggattacaggcatgagccactgtgcccggccaaca catgtatttttaataacctaagtcattttttaaaaactgagatgtaattaatattccaca aaattcactgtttaaacgtgtacaatttagcagttttact >IGR1153a ttgcccaggatagtctggaactcccaggctcaagcaatctgcccgcctcggcctcccaaa gtgctaggattacaggcatgagccactgtgcccggccaacacatgtatttttaataacct aagtcattttttaaaaactgagatgtaattaatattccacaaaattcactgtttaaacgt gtacaatttagcagttttactttatttacaaggttatacaaccatcaccactatccaatt ccagagcatttgatcatcccaaaaggaaatctcatattcaatagcagtcactctattcct tcctcacctctagccccctggaaacattaatctgctgtcactggatttacctaatctgta catttattataagtggaatcgtacattatgtgaccttttgtgactggcttcttttgctta gcatgttttaagggttcattcatgtggtagcatgtatcctttttatggctgaataatatt ccattgtatgggtataccacattttgtttatctgatcatcagttgatggccatttgggtg tgtccatattttgactattacaaataatgctgctatgagcattcttgtacaagttgttgt gggaacatatgttttcaattttcttagttctatacctagaagtggaaaaactcagacgat ttacaggtgcccctagctaagaacctttgctttctaaaca >IGR1154a cattttgtttatctgatcatcagttgatggccatttgggtgtgtccatattttgactatt acaaataatgctgctatgagcattcttgtacaagttgttgtgggaacatatgttttcaat tttcttagttctatacctagaagtggaaaaactcagacgatttacaggtgcccctagcta agaacctttgctttctaaacattaacatttacttcaggcttcaatcataccaccctctac agaacctcgtatcaaggaataatgatgctgagatacactgtattttttttaaagccctgc gaagtctgttgaagactatacatgtcttcctttctatgaatagagacattatcctgtagt cagtataggaaactggttttcttttagcattgacacaatgtgaatcttgactaattgtga cttttttttttttttttttttttttaagacggagtctggctctgtcacccaggctggagt gcagtggtgcgatctcggctcactgcaagctctgcctcccaggttcacgccattctcctg cctcagcttcctgagtagctgggactacaggcgcccaccaccaggcctggctaatttttt gtattttttagtagagacggggtttcggcgtgttagccaggatggtctcgatctcctgac ctcgtgatctgcccgccttggcctcccaaagtgctgggat >IGR1155a tcactgcaagctctgcctcccaggttcacgccattctcctgcctcagcttcctgagtagc tgggactacaggcgcccaccaccaggcctggctaattttttgtattttttagtagagacg gggtttcggcgtgttagccaggatggtctcgatctcctgacctcgtgatctgcccgcctt ggcctcccaaagtgctgggattacaggcgtgagccaccacgcctggctgtttttgtttct gtttgtttgtttgtttgtttgagacggagtttcactcttgtcacccaggctgaagtgcaa tggtgtgatctcggctcactgcaatctctgcctcccaggttcaagcgattctcctgcctc agcctcctgagtacctgggattacaggcgcgtgtcaccacacctggctaatttttctatt ttcagtagagatggggttttaccatattggccaggctagtcttgaactcctgacctcagg tgatccgtctgccttggcctcccaaagtgctgggattacaggcatgagtcactgcgcctg gcctcctctctttatttgactactagaatcttcagcaagcatatcagacttcatgcatac tttttatacacttctctcctggtttcattactttcttgcccttatttctacactgccttg ttttcccattaatttgaaatacatttatctttgctctatt >IGR1156a tcccaaagtgctgggattacaggcatgagtcactgcgcctggcctcctctctttatttga ctactagaatcttcagcaagcatatcagacttcatgcatactttttatacacttctctcc tggtttcattactttcttgcccttatttctacactgccttgttttcccattaatttgaaa tacatttatctttgctctattgtatataactaagtaaataatttctggaacaaggaaggt tacaaagtaaactaataccatcagatccactaagtttagaccatcactttaaaaggggtc atagatcattaatcttaacaatttcgtatatatatacagagagctgctgcgaatttacag attgtgatttttatataggcaactacataaaagctagtgataattattttgttatatatg catcataaatttatacagttattcaatatgtattaggccaggcagagatttgatctccct ttgactgatatttcatatatttgaaattcttggtggtacagaaagagacccagcagaaaa ctaatgtaactaatcttccaaatgattttaagcaaccacttataaccaagtggttaaggc attcaaatagtaaattttgtttaaaacagtaagaacagagaaatggtatagtttttaaag gcattaactaccatgcttgcataaagcatgtgatgatggc >IGR1157a tttgaaattcttggtggtacagaaagagacccagcagaaaactaatgtaactaatcttcc aaatgattttaagcaaccacttataaccaagtggttaaggcattcaaatagtaaattttg tttaaaacagtaagaacagagaaatggtatagtttttaaaggcattaactaccatgcttg cataaagcatgtgatgatggcttcttaatatgattttgattatactatagaaattaattt ctttaatagagaaaataaatgatataggaatcaactggaaaatgacttaatatataaata ttttccttacagattactttcaagattattaaaccttaatccgtcttttgtgaatttatg ctacataaagatatgttagaataagaaaagatacagatacatgttaaagatgttcattgt cacacagtttgtgataaggaaatgaaatcaatctgagtaagtgctggtatatacacaaaa tggactattttataatcattaaaaagaatgtgatacatctgtgagttgataggtaaaatc aaattatgttaagtgaaaaaaggtacagaataacatgatacgaccccatccataaaagta aatttaaatatatatatatatatatacacacacacctaaatttatctacctatctgctgg tatatgaataaaaaacttctttaagaacaaataagtgtaa >IGR1158a taaaaagaatgtgatacatctgtgagttgataggtaaaatcaaattatgttaagtgaaaa aaggtacagaataacatgatacgaccccatccataaaagtaaatttaaatatatatatat atatatacacacacacctaaatttatctacctatctgctggtatatgaataaaaaacttc tttaagaacaaataagtgtaacagttaatgacatgtagaagtaagattgagaattaggag aaggggaggaacacttttatgcctttatgttcgaacttttaccatgagtcttttactgaa aataaaaataaaaaataaatgaagtaagaatgttattggaattatttttctttacttttt gcatttctttttagagacagagtctcgctgtgtcgcccaggctagagtgcagtggtacaa tcacagctcactgcaacctctgcctcccaggttcaggtgattctcatgcctcagcttccc gagtagctgggactacaggtgcgcgccgccacggccagctaatttttgtattttcagtac agacagggtttcactgtgttggccaggctggtcttgatctcctggcctcaagtgatccac ccgcctcggccttccaaagtgcagggattacaggtgtgagccaccacgcttggcctcttt cctttttgcatttctattcaatggatcttctattgaaaat >IGR1159a tgcgcgccgccacggccagctaatttttgtattttcagtacagacagggtttcactgtgt tggccaggctggtcttgatctcctggcctcaagtgatccacccgcctcggccttccaaag tgcagggattacaggtgtgagccaccacgcttggcctctttcctttttgcatttctattc aatggatcttctattgaaaataaaactatagaaaagaatgtcataggtgtaagtgatatc ataagcaaaacagacctaccttctgtgtatcaatatcttgtctcatgagtctcatatctt catttatcttttctttgtgtttctcgcattcacttagttgagctattactttattaagtt cagtttctttttgctacaaaaaagaaaattctttaagcacatgaataaaaatacaatcaa ataaataattttaagttttaaattaccttcttatagtcgtctttcccatcttgaatataa ttctcaatgtctttcatatagccatgaatatttttaaccttctctttaatatcattcagc tgtagaaaaatattcattaaatttacactggttgtacttaagggcacataacaggagagc acagtaaaacactggctgggaagttatgaacattgggttccagtttccaccactactgaa ttttatgatcgcagacaagtccctttctcacctataggaa >IGR1160a agccatgaatatttttaaccttctctttaatatcattcagctgtagaaaaatattcatta aatttacactggttgtacttaagggcacataacaggagagcacagtaaaacactggctgg gaagttatgaacattgggttccagtttccaccactactgaattttatgatcgcagacaag tccctttctcacctataggaattgattaattagtctcatttcttaacttctattgtagat caagcagcaaaataatttacatcaaatccttgttctaacaagaatttctaatgtcaaaat tataccatgaatctgaaaatactatttatcttatgctatttaatttcatgtgaaataagt gtccgacgtggtgctatgaacataagtttaatacagatatttgataagtaaatatataaa tgaaatcttactttatcctgtgctattttgttgcttgtattttttttgttgattaattct tctttttcttgctggaacttttccaatgttgtttccaaagggcttacctgctctttagca tcctaaaaatataaaaaagataaagtattatataatattccattatcttactttaggggt cagacttcacagtcttaataaaagcactttctatgtgccaggctctaaaagtcaactcat ttgctcctttcaatgaccctatgaggacagtaccatcatt >IGR1161a tttccaatgttgtttccaaagggcttacctgctctttagcatcctaaaaatataaaaaag ataaagtattatataatattccattatcttactttaggggtcagacttcacagtcttaat aaaagcactttctatgtgccaggctctaaaagtcaactcatttgctcctttcaatgaccc tatgaggacagtaccatcattttcagtcctatatttcaaacgagcaaacagacacagaga atgatttgtccagggtcacaacagccagtaaatgaagcagccaagattttaacccagtcc agctccagagttcacgctcttaaccactacgcatgctatactgcatcaaccactaatttg attcttaatctaggccatgtgctcccaattatattagcgtgtggcttcaagcatgagttt tcatgattttataggtgcccgtcactgctgcatgatcaaagaataggaaagctcattcag tccagacttttctttttcagatgaaaacatgatggtaaaaacacttctgtccttaagctt agcctgctaaggctacgcagatatttcatggtaataaaagcatactgttaaactaatgtt ggtgtctccacaactattttggaaggaacggggctttcaagtaataaactattttactaa atagaagtccccattatttagccttgtaacactaaatcta >IGR1162a gatgaaaacatgatggtaaaaacacttctgtccttaagcttagcctgctaaggctacgca gatatttcatggtaataaaagcatactgttaaactaatgttggtgtctccacaactattt tggaaggaacggggctttcaagtaataaactattttactaaatagaagtccccattattt agccttgtaacactaaatctacaacgtagttatatgataaccacagttcaaaacagaggt cctcaagcactttaagattctgaagtactgagtgaatctatagaggtagatacaattatt tagtaattacttcaatataggtctattttatcatactgggaagtggtatggtgtgttagg aagtcaaatgccctcagtgtcaaaagatctatcagaaaatcaactctgcttcctattagc tgcataaacttaggcactcatgagacatttgtaaatctcaatttttctataaagagattt catcatctaaatagggttgctgaggcactgaatggttcaatgtcaaagtgctttataaat agtaaaaaattatacagatgcaagtactattttatattatattctgaacctctgatattt tgtaatctaaaatttaataaaaatttatagtaattattcagtaatatacttagtgcttat tgaatgagtacgcataattatataaacctaggtaagattg >IGR1163a ctgaggcactgaatggttcaatgtcaaagtgctttataaatagtaaaaaattatacagat gcaagtactattttatattatattctgaacctctgatattttgtaatctaaaatttaata aaaatttatagtaattattcagtaatatacttagtgcttattgaatgagtacgcataatt atataaacctaggtaagattgtttataactgtttataactggttgagtcttagatgtgat taatctatataagggatgtcaaatgcattccagtggcaactgagtgcctgctcactgtat tggtaagggttctgaaaccacatccggaatcaaatggaaagagtgctatgactgagagtg accgccatagataaaggatctgcagataagacaaacctcctgtacaagcaggaatcctta tacagaattaaccaaccaccacctgaccacctccaataacatttactacttaaccaggca gccagttcttccttattatggcaaactccttcttccagaaatctttacttactagtacaa gttctatcacttaggaaccacacaaataattattataccattttcatttgatcctcataa tagctggttttcaaagggaatgcttccagtttttgcccattcagtatgatattggctgtg ggtctgtcataaatagctcgtattattttgaaatacattc >IGR1164a ggcaaactccttcttccagaaatctttacttactagtacaagttctatcacttaggaacc acacaaataattattataccattttcatttgatcctcataatagctggttttcaaaggga atgcttccagtttttgcccattcagtatgatattggctgtgggtctgtcataaatagctc gtattattttgaaatacattccatcgatacctagtttattgagagcttttagcatgaagc ggtgttgaattttatcgaaggccttttctccatctattgggataatcatgtggtttttgt ctttggttctgttcatgtgatggattacatttattgatttgcatatgttgaaccagcctt gcatcccaggaataaagccgacttgatcgtggtggataagctttttgacgtgctgctgga ttcggtttgccagtattttattgaggatttttgcatcgatgttcatcagggatattggcc tgaaattttctttttttgttgtgtctctgctaggttttggtatcaggatgatgctggcct tataaaatgagttagggaggattccctctttttctattgttaggaatagtttcagaagga atggtaccagctcctctttgtacctctggtagaattcggctgtgaatctgtctggtcctg gacttcttttggttggcaggctattaattactgcctcaat >IGR1165a tgtgtctctgctaggttttggtatcaggatgatgctggccttataaaatgagttagggag gattccctctttttctattgttaggaatagtttcagaaggaatggtaccagctcctcttt gtacctctggtagaattcggctgtgaatctgtctggtcctggacttcttttggttggcag gctattaattactgcctcaatttcagaacttgttgttggtccatttggggatttgacttc ttcctggattagacttgggagggtgtatgtatccacgaatttatccatttattattttct agtttatttgcgtagaggtgtttatagtattctctgatggtagtttgtatttctgtggga tgggtggtgatatcccctttatcattttttattgcatctatttgattcttctctcttttc ttctgtattagtcttgctagtggtctattttgttgatctttttaaaaaaccagttcctgg attcattgatttttttgaagggtttttcgtgtatctccttcagttctgctctaatcttag ttatttcttgtcttctgctggcttttgaatttgtttgctcttgtttctctagttctttta attttgatgttaaggtgttgaattcagttatttcctgctttctcttgtgggcatttagtg ctataaatttccctctacacagtgctttaaatgtgtctca >IGR 1166a gggtttttcgtgtatctccttcagttctgctctaatcttagttatttcttgtcttctgct ggcttttgaatttgtttgctcttgtttctctagttcttttaattttgatgttaaggtgtt gaattcagttatttcctgctttctcttgtgggcatttagtgctataaatttccctctaca cagtgctttaaatgtgtctcagagattctggtacattgtatctttgttctcactggtttc aaagaacatctttatttctgccttcatttcgttatttaaccggtagtcattcgggagcag gttgttcagtttccttgtagttgtgcggttttgagtgagtttcttaatcctgagttctaa tttgattgcactgtggtctgagagactgtttgttatgatttctgttcttttgcatttgct gagagtgttttacttccaattatgtggtcaattttagaataagtgcgatgaggtgctgag agttctggccattacactaataaagagcatttcatattaaagaaacatgggctgggtgag gtgatgtaagcctgtaattttgggaggccaaggctgcattgcttgaggccatgagtttga gaccagcctgaacaacatagtgagaccctgtctctagaaaaattttaaaaattagccagg cgtggtggtgtgtgcctgtagtcccatctacttgagaggc >IGRI 167a ataaagagcatttcatattaaagaaacatgggctgggtgaggtgatgtaagcctgtaatt ttgggaggccaaggctgcattgcttgaggccatgagtttgagaccagcctgaacaacata gtgagaccctgtctctagaaaaattttaaaaattagccaggcgtggtggtgtgtgcctgt agtcccatctacttgagaggctgaggcaggaggattgcttgagctcaggaggtcgaggct gcagtgagtgagctgtgactgtaccactgcattccagcttggaagactgatgaagactct gtctctaaaagagaagaatggggcggggcatgctggctcacgcctgtaatcccagcactt tgggaggccaaggtaggcggatcaccttagttcaggagtttgaaaccagcttgtccaatg gcgaaaacccgtctctactaaaagaacaaaaattagccaggcatggtggtgcacgcctgt aatcccagctactccagaggctgaggcaagagaatcacttgaacccaggagatggaggtt gcagtgagccgagatcgtgctactgcactccagcctgggtgacagaacgagactgtctca aaaaataaaaataaaaataaataattaaaataattttacaaaaaacatgtatggatattc ttacctttatctctctgtacaaagactgaacttcagtgga >IGR1168a gctgaggcaagagaatcacttgaacccaggagatggaggttgcagtgagccgagatcgtg ctactgcactccagcctgggtgacagaacgagactgtctcaaaaaataaaaataaaaata aataattaaaataattttacaaaaaacatgtatggatattcttacctttatctctctgta caaagactgaacttcagtggataattccacagtctgctcctccagttgctgacgacgttg caaattagtggatatctgaagtttctcagattttagctcatttgttgtactttttagatg ttgaatctgttcctgctggtcctgtataagcttacgattcaattcaatcttactagaaac tacacaaaaacatattatcacagtaattaatgtaagggcatagaaaatactatttgtatc attcttcccatttttatcggtctatggaatccacaaatgctatttctgtgggccccaccc actgcaacaaaaatacaatgagaaccctgctagttctcaaatcagcttgatgttccctgc tggccactcacagggaaagcttacagggcaggtatgaatgagaaagaatacagctcatgg ccaggcgcactggctcacacttgtaatcccagcactttgggagactgaggcaggtggatc acctgaggtcaggagttcgagatcagcctgacaaacacag >IGR1169a gagaaccctgctagttctcaaatcagcttgatgttccctgctggccactcacagggaaag cttacagggcaggtatgaatgagaaagaatacagctcatggccaggcgcactggctcaca cttgtaatcccagcactttgggagactgaggcaggtggatcacctgaggtcaggagttcg agatcagcctgacaaacacagtgaaaccccatctctacgaaaaaatacaaaaattagctg ggcatagtgatgtgtgcctgtaaccccagctactcaggagggtgaggcaggagaatcact tgaacccgggaggcggaggttgcagtgagccaagattgcaccattgcactccagcctggg cgacaaaagtgaaactctatcttaaaaaaaaaaaaaaggaaaagagaatacagcttattt catactctcctactgttcaaaatctgttgtgcaaagtaagagaacaaagagaagtgatgc ttttcagaaaaaaagagcaaatatatgtggacaggaaggaacttcgttgtccatgtaaca gatataaaattgactgtaaaaggcatgtgctcgcaatgtcaaagtctctatgagtacaga aggacacagactgtattacctgtgtctaacttgtgctgtttctcttgtttctcctggttg acttgttggacagttcgatctaagtctattccttgtagct >IGR1170a aatatatgtggacaggaaggaacttcgttgtccatgtaacagatataaaattgactgtaa aaggcatgtgctcgcaatgtcaaagtctctatgagtacagaaggacacagactgtattac ctgtgtctaacttgtgctgtttctcttgtttctcctggttgacttgttggacagttcgat ctaagtctattccttgtagcttagctgcttgttgtgcaatttttctttcaacatctttaa gttccatcttaagaatataacaaaatgatttcctttaataaacttactgcattattcaaa atctttaaaaattaattgctcttatcatttattttttaaatctaaacttataaaccattt ctagatacaattttagcaaagtttaataggataaaagtgaaattaattatcagcaattca aatgatgtaaacaaaaggaagctgactaaagatgaaaaacaaacagaactgtcttaattt ttaaatttatgaattaaaaagtttaaacccagggatgtaaactaagcagtttctccctga gggtatctgaaattcaggatggggaattctaaacacaacctgtacctgaatactagctac tatttttaactctcacacttcaaattcaagccaccatggaacaagttttattctgcctta aactacaataaacttacctggaacctctccataattgtaa >IGR1171a agtttaaacccagggatgtaaactaagcagtttctccctgagggtatctgaaattcagga tggggaattctaaacacaacctgtacctgaatactagctactatttttaactctcacact tcaaattcaagccaccatggaacaagttttattctgccttaaactacaataaacttacct ggaacctctccataattgtaacatctgtcaggcatactttggcactttcttcttcaggca ttattgtacccaagagtgtttcttgttcttctatgtcgttctttaggcgctgtatgtctc tattgacattctgcagtttgtttcttaattctggtatttccttctccttcaaatcaatta tgctttgcctaaatagaaaacacaattaaaaataaagtatctgatgtttctcacagttag actgaggttatgtatttttaggaagaataccacagaagtgacattgtgttcttttcaggg tatcatatcagtggatatggaatcatgatatcaatatgtcttattactgatgatgttaat ccttattcacttggcttagatggtgttggccaggtttctccactgtaaagttactgtttt agtctttgtaattaacaagtatcttaggagagaaatgttgagactatgtaaatatcttgc ttctcaactttctgcctactgattttagtatccactgaca >IGR1172a gaatcatgatatcaatatgtcttattactgatgatgttaatccttattcacttggcttag atggtgttggccaggtttctccactgtaaagttactgttttagtctttgtaattaacaag tatcttaggagagaaatgttgagactatgtaaatatcttgcttctcaactttctgcctac tgattttagtatccactgacagatcttgcttgcaataattattactgtggtgtttgtcaa actgagaaatattctactaatgaactggtcatattgaccaaaagtgttaaggtcatgaaa gataaagacagattgttacagactgcaggagcctaaggagaaataacaactagatgctac gtgggatcctgcatggaaccctgaaacagaaaaggcattgatggaaaaactgctaaattc gatatggtctgtaatttagttagtagcattatatcaatgttaatcctggttttgataact gtattataacagagtacataaattgttaacatcaggaggagctggatgagggatatatat gaataatttgtattatttttataatttttctgtaatcctaacattatttcaaaataaaaa ttttttaaattacaggaaaaaaaggaaggaagccagccactaagtgaaatgctacatggg tttaaggtacaaaatgtcaacccattttactggtactcac >IGR 1173 a aaattgttaacatcaggaggagctggatgagggatatatatgaataatttgtattatttt tataatttttctgtaatcctaacattatttcaaaataaaaattttttaaattacaggaaa aaaaggaaggaagccagccactaagtgaaatgctacatgggtttaaggtacaaaatgtca acccattttactggtactcactactgtagctaatgaattaccacctccatggcaggtact gacaactatttttgctgatgcctctgaaacaataatatgtatttaatcttttaaaaaaaa tttacttcagaaatattccaaattcttatttaaaattatattgaattagtatgacaaagc agtagaataaattaaactggtctctaataggagtcttattataaacttaaagaataacca gaaactcaagtggctattacttaatgattttttaaaaatgcaaactatgaccaagaaatg ccaacctgacctgtggcaacagacctatagttttttaaaattttttaattatttatttat ttttatgctttaagttctgggatacacgtgcagaacgtgtgggtttgttacataggtata cacgtgccatggtggtttgctgcacccatgaacccatcatctacattaggtatttctcct aatgctatccctcccctagccccccaccagcagacaggcc >IGR1174a cagacctatagttttttaaaattttttaattatttatttatttttatgctttaagttctg ggatacacgtgcagaacgtgtgggtttgttacataggtatacacgtgccatggtggtttg ctgcacccatgaacccatcatctacattaggtatttctcctaatgctatccctcccctag ccccccaccagcagacaggccccagtgtgtgtgatgttcccctccctgtgtccatgtgct ctcattgttcaactcccatttatgagtgagaacatgcaatgtttggttttctgctcctgt gttagtttgctgagaatgatggtttccagcttcatccatgtccctgcaagggacatgaac tcatccttttatatggctgcatagttactccatggtgtatatgtgccacattttctttat ctagtctatcattgatggtcatttgggttggttccaagtctttgctatcgtgaacagtgc cgcaataaacatatgtgtgcatgtcagacctacagtttttttttataccacagaaatagg aggtatttgtattccacataataaatatgaaggtatgcaggttatgagtaattccatgcc aatgtttcctcttgaacactgttgtcacagattagtagttggccttaaattatgtgccca atatctaaaaagtgacacagctatgacagcctaataatga >IGR 1175 a catgtcagacctacagtttttttttataccacagaaataggaggtatttgtattccacat aataaatatgaaggtatgcaggttatgagtaattccatgccaatgtttcctcttgaacac tgttgtcacagattagtagttggccttaaattatgtgcccaatatctaaaaagtgacaca gctatgacagcctaataatgatggccaagcatttattaaactggggacatctctgtgaag aactgtaggtatacatacaattttaaccctatttttacattttcctacacacacacaaaa tctttcatcaatatggtctaggttttggtgccttcttttttgatgattacataagatgtt aaaagaagttttctggccgggtgtgacggctcacgcctgtaatatgagcactttgggagg ctgaggctggtgaatcacctgaggtcaggagttcaagaccagcctggccaacatggtgaa accccatctctactaaaaatacaaaaaatcagttgggcgtggtgaagggcgcctgtaatc ccagctacttgggaagctgaggcaagagaactgcttaaacccgggaggtggaggttgcag tgagctgagattgtgccactgcactctctgggtttgtttttcttttttttaaatttatga cattttattttttattttcaagagttaatttttctcacga >IGR1176a tacaaaaaatcagttgggcgtggtgaagggcgcctgtaatcccagctacttgggaagctg aggcaagagaactgcttaaacccgggaggtggaggttgcagtgagctgagattgtgccac tgcactctctgggtttgtttttcttttttttaaatttatgacattttattttttattttc aagagttaatttttctcacgattcacaaggttttttaaaattattttcaatagataaatc ataattgcaaacatttatggggtacaatgtgatgttctgatatatgtacacaatgcacaa tgattaaataaaggtaatttaacatatccattaccttgcctgcctatcattttttataga cagacatttgaaatttactctttggatttctgttttttcagaaactcaattcacctattt ttagacaacattccttttctaaggggattgtgtgtaaaaaggctcacacagatatggtac tgaaaaaaacctgtgggagaaataccaattgagtttgcatttaaatgaggtgctataata aatgaatctgagtcagtactagacaaaatgataaacaggtacattttcagctgagatctc agtcatgatgttaggtttatattagatactggcgaatttgaggctttaaatgaaaatatt tcccgcaaagaagataagcaagatatggctccccactacc >IGR1177a aaataccaattgagtttgcatttaaatgaggtgctataataaatgaatctgagtcagtac tagacaaaatgataaacaggtacattttcagctgagatctcagtcatgatgttaggttta tattagatactggcgaatttgaggctttaaatgaaaatatttcccgcaaagaagataagc aagatatggctccccactacctctctgagctcatcttccacaacttttccctttggcctt caggtcaaatatgtctcagagattttgcactgcctagaatattcttcttatggacaactg catggctgactccctcacttctctcaagtttccactccactgccaccttcatcaagtccc ctcctaccacccttcagctagtccctattcccttatcttgctgtagttttctcaatgccc ctgatcatcccctggcatattatatatttacttatttgtcatccatctcctccccactgg gatataaactccatgagggcagggactttgtccattttgtttactgctgtattacctgca ctccagtagactgcctatattggttgcatgaatagacagttctcatgatagtggtggcat caagggcatattctaaaggtgaaaaagcaaatggtgcacagataaatttaatcttgttac tttacccctcttcaccaataaccttccacctaagtgacta >IGR1178a cagggactttgtccattttgtttactgctgtattacctgcactccagtagactgcctata ttggttgcatgaatagacagttctcatgatagtggtggcatcaagggcatattctaaagg tgaaaaagcaaatggtgcacagataaatttaatcttgttactttacccctcttcaccaat aaccttccacctaagtgactatcataaatagacctccacaatgtctctgaaagtgacccc acgggatatttgaaagtagtatcctaaccagaggtggaaggaagcttaatgatcatgtaa atcaatcccctcactttacgtgggggatacgaaggcccaaatgggttaagtaacatccct aaggtcacccagcagagttggaatttgaagtcaacctgactgcactcttaggcaattgct ttcccatatttaaaaaaaaaaaaagtcctcttggttgggcatggtggcttatgcctgtaa tcctagcactttgggaggctgaggtaggaggattgcttgagcttaggagttcgaggcttc gatgagctataatcaatcacaccactacactccagcctgggtgacaggagcaagacccta tctatcaatcaatcaagtcctcttaattcattattgacctttcatttgtggatttattta aacttaaaaaaagtgttttataatgttatttcctactatt >IGR1179a tgaggtaggaggattgcttgagcttaggagttcgaggcttcgatgagctataatcaatca caccactacactccagcctgggtgacaggagcaagaccctatctatcaatcaatcaagtc ctcttaattcattattgacctttcatttgtggatttatttaaacttaaaaaaagtgtttt ataatgttatttcctactattgggaagaagacttcctctctcatttgtcccaaactcatc cttctccagttttccagaatggcccactgacattctgttagagcttgctaaacaaacagg ggttcatcatttccctgctcttcgggtcttcaagttttggtttctttataaaaatggttt cctcacacatgtgtcctcacttagcagccctgccagcatcttggtccattttcagtgctt cctgtaggccttttctagcttcaggttctcttaaaatgtgtggtaaccagccatttacct ggctaacctagctgagcccagtcatcccatgaaaccatgaaaaactaatcactgcgagac agttttgagggggtttgttacaagcaatcaataacgggaatagacactacagttctcatt cattcagcaaatagttatcaaagttacaatatagaatatacaaatgtgtggttgcctagt ctctaggtaaccagaatggcacacagatgctactgcagat >IGR1180a agtcatcccatgaaaccatgaaaaactaatcactgcgagacagttttgagggggtttgtt acaagcaatcaataacgggaatagacactacagttctcattcattcagcaaatagttatc aaagttacaatatagaatatacaaatgtgtggttgcctagtctctaggtaaccagaatgg cacacagatgctactgcagatatagggttaggcagattcaagtcagccacaagtacttcg acactcttcccatcaagagatacagtatcctccctcactgaatcttgggagtttctgtga ccactctaaccaacagaaaaagaagtgtcaccatgccagtttcttggtctaggccttaaa ggacttgcagcttctacttcctgttcatggaatacttacccttaggatactctgtttagt aacccagtcactgtgctgccaaaagcccaagacgcatgcagaggccatgtgaagatgtcc tattttgacagccccagctgagctcccagacaatagtgagcatcactgtcagtcatgtga gccatcaagaacatccagctcggttatgctttgagacgactgcagccaacatctgactgc aaccgtaagaccccaagtgaaagccacctagctgagcccagtcataccacagaaccatga aaaattattgtgagacagatttgaggtttgttacatagca >IGR1181a gagctcccagacaatagtgagcatcactgtcagtcatgtgagccatcaagaacatccagc tcggttatgctttgagacgactgcagccaacatctgactgcaaccgtaagaccccaagtg aaagccacctagctgagcccagtcataccacagaaccatgaaaaattattgtgagacaga tttgaggtttgttacatagcaataaataattggaacagacattacagttctcattcattt agcaaatagttatcaaagttgcaatatacaaggaactgtggagatacaacgagtaagaca tgcaccttactcttagaggggaaactgtggcccagcacggtggctcacgcctgtaatccc agcactttgggaggctgaggcaggcgattgcctgaggtgaggagtttgaaaccagtctgg ccaacatggtgaaaccctctctctactaaaaatacaaaaaaaattagccgagcctggtga cgtgcgcctgtaatcccagctacttgggaggctgaggcaggggaattgcttgaaccgggg aggtggagattgcagtgagccaagactgcgccactgtactccagcctgggcgacaaagca aaactctgtctcaaaaaaaaaaaaaaggagccgtgatagctagggtcctaaaatataata cgatgttaatttctgccatttattgtataacagtctaaca >IGR1182a ctacttgggaggctgaggcaggggaattgcttgaaccggggaggtggagattgcagtgag ccaagactgcgccactgtactccagcctgggcgacaaagcaaaactctgtctcaaaaaaa aaaaaaaggagccgtgatagctagggtcctaaaatataatacgatgttaatttctgccat ttattgtataacagtctaacacagaactaagctcatatttctactacgtgtactttctac caatttcaaattttatccatttgatctttttcttttcaagatactaccttattcctctcc ttcctttttattctcaaactactgcctctgtctcctcatctctgtggccccaataatctg gttttcacccttgatgcttgtgttggttatctattgttgcataacaaagtatcccaaaac ttagcagcttaaaataacagcacttattatttctcagagatatgaggatcaagagatacg cttctgactcagggtctcgcatgaagtcgcaatcaagctgtcagccaggactgcagtcat cttaaggcttgactgctacaaagtctgcttccaaactcacttgctcaaaggcctcaggtc cttggcatatgggcctctccagagggctgcttgcaacatggcagctagcttccctcagac aagagacagagggagacagagtgagtgagagaggggagga >IGR1183a catgaagtcgcaatcaagctgtcagccaggactgcagtcatcttaaggcttgactgctac aaagtctgcttccaaactcacttgctcaaaggcctcaggtccttggcatatgggcctctc cagagggctgcttgcaacatggcagctagcttccctcagacaagagacagagggagacag agtgagtgagagaggggaggagtgggggagagtgagcgagttcacacaagggtacaagca cattgcgagaacagaagaagccatagtaccttaaataacctaatgttggaaaggccatgc tatcacttctgcctgttttatcagttatatagaccaatcatgcaacagcatgagatggga ctatacaagagtataaataccaagaggccgagattactagggaccatcttagaagttggc tgccacaaaccacatcttcttaggcctttctttctccttttcctgaaactcctccttggt tttccaggacaatcactttcactctcctggtttttctgcttcctgagcttttctcagcct gtttcagtcaatatattaatattagattaattttcctaaaatacatctttcactaactcc cttaggttggctcctcatcacctatcagagttacaactagacctgaatataatgtagccc tatctccccaacatacaggactcaatccctataaataatt >IGRI 184a cactctcctggtttttctgcttcctgagcttttctcagcctgtttcagtcaatatattaa tattagattaattttcctaaaatacatctttcactaactcccttaggttggctcctcatc acctatcagagttacaactagacctgaatataatgtagccctatctccccaacatacagg actcaatccctataaataattccccaaactccagataacatttctactgcagcataggtc atactcctcttccctttgcaccgtgttctgacttccgtctcctctcagttgagctgaatg aacttctccaggtcttatattcctcttcctgcctcattctcaaaatattcttctcattct gtatccattggctcctcccttcttacctaacacatctgtttgaatcattttttaagcact ttattaagcctagctttctaaatgttgaattctgagagcttgtcttcttaatcagaccat tagctcctggagggtcatgtcttaggtctctggcactagccttgttctctatgttctggg agacactaaggcaatcatcacatatttcctgacttgatttttgtttgtaaacagaacata acacgaatttcttgtataagtgatggaaaatataaacaaccgaaaatcatctatgattca ttcttttagcaagtggaaaagacattaaaaacatagttta >IGR1185a tcttaggtctctggcactagccttgttctctatgttctgggagacactaaggcaatcatc acatatttcctgacttgatttttgtttgtaaacagaacataacacgaatttcttgtataa gtgatggaaaatataaacaaccgaaaatcatctatgattcattcttttagcaagtggaaa agacattaaaaacatagtttaaaatctgtcttctgggagaacttttcaatacttaaattc ttttgctgggttcagaaagtggcatgtcaacagacagtcctaaatctgtgaaaatctatg cccacaagctaagtcttgggaattaaacacacatacaaaagaacgtaaagactgtgtcta cctcatagtttaagaaataagcttactggctatgcacggtgctcacacctgtgatcccag cactttgggaggccgaggtgggccaatcactttgaggccaggagctcgagattagcctgg ccaacatggtgaaactccatctctactaaaaattacaaaaattagctgggcgtggtggta catgcctgtaatcccagctactgaagaggctgaggcatgggaatcgcttctgggaggtgg aggttgcaatgagccaagatcatgccactgcactccagcttaggtgacagagagagactc tgtctcagaaaaaaaaaagaaaaagaaaaaaagacaggaa >IGR1186a tctctactaaaaattacaaaaattagctgggcgtggtggtacatgcctgtaatcccagct actgaagaggctgaggcatgggaatcgcttctgggaggtggaggttgcaatgagccaaga tcatgccactgcactccagcttaggtgacagagagagactctgtctcagaaaaaaaaaag aaaaagaaaaaaagacaggaaacaagcttatctttaaacaaaataattgaatcttcttat catagaagtgatataagacagggcataccagctcagagtccttactgagtaactaccatc tgcccaggcatgagatgggtaccttttacaatgtgctgctacatgtacagtgaaggtaaa tcccattcttacctcatgggcacaagtcccagcatttcatcacgccgcttttcctttttt tttagctctgattctgttgacttgagtttatctggagcaagtcgcagtttagactgcaaa tcactgatgacttcttgtaactcagcctctgtctgaaaaactctctgacaaacggggcaa catgactggttttcgtctgttagctgagtaatgaactgggagtaaactgctgtggctcca gccagcatggctattttaagaaaataaattatatcaccaatgagaaaaaaacataaaata cagtattctgaatacggttgtatctttttctataaatata >IGR1187a actcagcctctgtctgaaaaactctctgacaaacggggcaacatgactggttttcgtctg ttagctgagtaatgaactgggagtaaactgctgtggctccagccagcatggctattttaa gaaaataaattatatcaccaatgagaaaaaaacataaaatacagtattctgaatacggtt gtatctttttctataaatatatgattattcttgctttataaatatattataaaagaaata aaaattctgatatttaaaattccgatattcgcttccaaagagcatgatacattcagattt gtataaatattttttggtaacacattataagtataacaaaatgcctactgagagctttct atgtgccaggcactgttctaagggctttataattacaatctcattcacacctcagtacca caggtggtagttgtgtcctcattttatagacaatgaaacacaggaaggtttcagtaactt gcctaaagtcacacagtgagtaagttgtagagccaggactgaaatccaagccattaggct ccataaccaggtttttaaattccccatccttaacagttacctgtgaatgaaaattcaaag gtgtcaaagtatcctgataatataaagtagacaacttacctcgctgttttgatgattttt caatttcctctttaagcctgtctaaatcactttcaaaatc >IGR1188a gtaagttgtagagccaggactgaaatccaagccattaggctccataaccaggtttttaaa ttccccatccttaacagttacctgtgaatgaaaattcaaaggtgtcaaagtatcctgata atataaagtagacaacttacctcgctgttttgatgatttttcaatttcctctttaagcct gtctaaatcactttcaaaatcctggctaccacaaacatcaaacagcttgtcttcgtaact ggacaactgctcttcctttctttttagttcattatttatatgatttttattctgctcaga tgaagctagttccttgctaaaataagagcaaatatggattttcattttaaaataggagaa attagtttgaaaatttgagtaggcaaaaacaagacaaattctgccaacaaatcatgacaa gagtttggtatgaccaaataatttttttcagaagttgagggactagtccacttctgcctt aactctccccctaggacactgactcacctgccagtcctactcatgggcctgctcccagaa aaatgtacacagaattctgcctggtttctgggggttcatggtctttgatcccaggttaag cctcagcaagatgcttgctaggactattggacagaaagaagacaagagaacatccccgta attccctttagtcctttcacaaatactacttccttactct >IGR1189a tgactcacctgccagtcctactcatgggcctgctcccagaaaaatgtacacagaattctg cctggtttctgggggttcatggtctttgatcccaggttaagcctcagcaagatgcttgct aggactattggacagaaagaagacaagagaacatccccgtaattccctttagtcctttca caaatactacttccttactctcctgtaaatactgtttcttttgtatcctccccctccttg ttgctgtcatccacttgcgtccagatcagtcattccctctcattcatcaaagattttgct tactagtacaatttatccccactttaattcttaaacatcatcctagccaacctcaatact cacacataacatggtttttcaatttgcaggtttagatgcattagctaccatgtaatcaat ttaatgtattcagcatattttttaaaaatgaaacagaatagacggtaatatattggagta ggctgtatgtatatgtactactttgagaaatttgtttcagataaatgtgtgtgactgcac acatgcttcttcatcatgactacccatcctgagtcacagtaaacatttggaaaaaagtaa ctaatatgatgatattttcattatcctagactcccttgagcacttctcatcaagatcacc agtgacctaagtgccaagtacagtcttcatcttactctac >IGR1190a actttgagaaatttgtttcagataaatgtgtgtgactgcacacatgcttcttcatcatga ctacccatcctgagtcacagtaaacatttggaaaaaagtaactaatatgatgatattttc attatcctagactcccttgagcacttctcatcaagatcaccagtgacctaagtgccaagt acagtcttcatcttactctacctctacgtagcaccaaacactgttgaccttctccttgaa gactattttcccaaggcacctagacaccacagctatctggctctcaccctggttccctgg gcacatcccagtttccttcacttgctccttttcctttgcctgctaacattttaaatgttt gtgcttcccaggaatctaattgtaactccttccctttgcataactctctcaaggtgacat actaatgactttgagtatcccttacatagcaacaacttccaatctcctgaatttcaaact ccaatattgtattccctcacagatacttccacaagaaacacagattaaacaccaccaaag ccaagtccttctactttcctcaaaaatctgtgtggaatttttgacccgcttatccaacca ctatccaaggtaacatctgagaaacatgatcactttttataatggattactcacagaaat gaaaatagaatttttaaattttaatcttcataggtctaca >IGR1191a cagatacttccacaagaaacacagattaaacaccaccaaagccaagtccttctactttcc tcaaaaatctgtgtggaatttttgacccgcttatccaaccactatccaaggtaacatctg agaaacatgatcactttttataatggattactcacagaaatgaaaatagaatttttaaat tttaatcttcataggtctacaaattttcaagggacaagaggcctaaattactatccgtta ccattttacttaatttgcaaaatatgaggggtcttcaaaatgttcatggaaaatgtgtat tataaaaaaaactatgcatgaagttcaaaatgttttgcactgaaacaaactcatactaac ttgttataacatgtctgaataggatctagtttaaggcactaacaaggttaagacatcagt ttgaaaagagccccaattaaactgaagcaagaacaagtatcaaatttatggtgaagtgtg ggtggaagaatggtgaaatcattgatactttacaacaagtttatgagatcaatgccccaa acaaatcagcagtttacaaatggataactcagtttaagaagggatgagacgatattaaag atgaagcccacagtgacagactgttcacatcaatttgtgaggaaaaaaaatcatcttctt catgccctaactgaagaagatcaatgattaacagcagaaa >IGR1192a cattgatactttacaacaagtttatgagatcaatgccccaaacaaatcagcagtttacaa atggataactcagtttaagaagggatgagacgatattaaagatgaagcccacagtgacag actgttcacatcaatttgtgaggaaaaaaaatcatcttcttcatgccctaactgaagaag atcaatgattaacagcagaaacaatagccaacaccatagacacctcaattgattcaggtt acacaattctgactgaaaaattaaagttgagtaaacgttctacttgatggatgcccaaaa tcactgcttccagatcagctgcagacaacagcagaacttcctcaataagtgggatcaagt tcctaaagcatttcttcaaagaattgtaacaggaggtgatggaatgtggctttaccagta caatcctgaagacaaagcacaatgaaagcaatggctaacaagtggtggaagtggtccagt caaagcaaaagcagaccagataagagcaaaggtcatggcaacagttgttggggatgctca aggcattttgcttgctgactttctggagggccgaagaaaggtaacaactgcttattatga gagtgttctgagaaagctagccaaagcattagcagaaaaatgcccaggaaagcttcacca DEMANDE OU BREVET VOLUMINEUX
LA PRESENTE PARTIE DE CETTE DEMANDE OU CE BREVET COMPREND
PLUS D'UN TOME.

~~ TTENANT LES PAGES 212 A 232 NOTE : Pour les tomes additionels, veuillez contacter 1e Bureau canadien des brevets JUMBO APPLICATIONS/PATENTS
THIS SECTION OF THE APPLICATION/PATENT CONTAINS MORE THAN ONE
VOLUME

NOTE: For additional volumes, please contact the Canadian Patent Office NOM DU FICHIER / FILE NAME
NOTE POUR LE TOME / VOLUME NOTE:

Claims (6)

WE CLAIM:

1. A method of assessing the genotype of an individual comprising the steps of:
a) obtaining a nucleic acid sample from an individual to be tested;
b) rendering nucleic acid molecules in the nucleic acid sample available for hybridization;
c) contacting the sample with at least one allele-specific oligonucleotide that hybridizes to a portion of a gene selected from the group consisting of the genes listed in Table 3, wherein said portion is at least 10 nucleotides in length and comprises a polymorphic site identified in Table 3; and d) identifying hybridization between the allele-specific oligonucleotide and the nucleic acid molecules.

2. A method according to Claim 1, wherein the sample is contacted with more than one allele-specific oligonucleotide and wherein each allele-specific oligonucleotide hybridizes to a portion of a different gene listed in Table 3.

3. A method according to Claim 1, wherein a central position of the allele-specific oligonucleotide aligns with the polymorphic site of the portion.

4. A method according to Claim 1, wherein the allele-specific oligonucleotide is a primer and wherein the 3' end of the primer aligns with the polymorphic site of the portion of the gene.

5. A method of analyzing a nucleic acid sample, comprising obtaining the nucleic acid sample from an individual; and determining a base occupying any one of the polymorphic sites listed in Table 3.

6. A method according to Claim 5, wherein the nucleic acid sample is obtained from a plurality of individuals, and a base occupying one of the polymorphic positions is determined in each of the individuals, and wherein the method further comprising testing each individual for the presence of a disease phenotype, and correlating the presence of the disease phenotype with the base.