CA2389722A1 - 15 proteines secretees humaines - Google Patents
15 proteines secretees humaines Download PDFInfo
- Publication number
- CA2389722A1 CA2389722A1 CA002389722A CA2389722A CA2389722A1 CA 2389722 A1 CA2389722 A1 CA 2389722A1 CA 002389722 A CA002389722 A CA 002389722A CA 2389722 A CA2389722 A CA 2389722A CA 2389722 A1 CA2389722 A1 CA 2389722A1
- Authority
- CA
- Canada
- Prior art keywords
- polypeptide
- seq
- human
- polypeptides
- antibodies
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
La présente invention concerne de nouvelles protéines sécrétées humaines et des acides nucléiques isolés contenant les régions codantes des gènes codant ces protéines. On décrit également des vecteurs, des cellules hôtes, des anticorps et des procédés de recombinaison utiles pour produire des protéines sécrétées humaines. L'invention concerne également des procédés de diagnostic et de thérapie utilisés pour diagnostiquer et traiter des maladies, des troubles et/ou des états liés à ces nouvelles protéines sécrétées humaines.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16434499P | 1999-11-09 | 1999-11-09 | |
US60/164,344 | 1999-11-09 | ||
US19529600P | 2000-04-07 | 2000-04-07 | |
US60/195,296 | 2000-04-07 | ||
US22136700P | 2000-07-27 | 2000-07-27 | |
US60/221,367 | 2000-07-27 | ||
PCT/US2000/030039 WO2001034768A2 (fr) | 1999-11-09 | 2000-11-01 | 15 proteines secretees humaines |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2389722A1 true CA2389722A1 (fr) | 2001-05-17 |
Family
ID=27389003
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002389722A Abandoned CA2389722A1 (fr) | 1999-11-09 | 2000-11-01 | 15 proteines secretees humaines |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1230360A4 (fr) |
JP (1) | JP2003513662A (fr) |
AU (1) | AU1448701A (fr) |
CA (1) | CA2389722A1 (fr) |
WO (1) | WO2001034768A2 (fr) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8460927B2 (en) | 1999-11-30 | 2013-06-11 | Mayo Foundation For Medical Education And Research | B7-H1 antibodies and method of use |
US8747833B2 (en) | 2004-10-06 | 2014-06-10 | Mayo Foundation For Medical Education And Research | B7-H1 and methods of diagnosis, prognosis, and treatment of cancer |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1261736A4 (fr) * | 2000-01-25 | 2004-12-29 | Nuvelo Inc | Methodes et materiaux associes a des polypeptides et des polynucleotides du type facteur-1 des preadipocytes (du type pref-1) |
DE60132699T2 (de) | 2000-06-06 | 2009-01-29 | Bristol-Myers Squibb Co. | Nukleinsäuren und polypeptide, die sich auf b7 beziehen und ihre verwendungen zur immunmodulierung |
US20030031675A1 (en) | 2000-06-06 | 2003-02-13 | Mikesell Glen E. | B7-related nucleic acids and polypeptides useful for immunomodulation |
CA2842429A1 (fr) * | 2001-10-19 | 2003-05-01 | Genentech, Inc. | Compositions et procedes pour le diagnostic et le traitement d'affections intestinales inflammatoires |
AU2003245536A1 (en) * | 2002-06-10 | 2003-12-22 | Avalon Pharmaceuticals, Inc. | Cancer-linked gene as target for chemotherapy |
WO2006101272A1 (fr) * | 2005-03-25 | 2006-09-28 | Reverse Proteomics Research Institute Co., Ltd. | Proteine cible et gene cible pour la decouverte d’un medicament et d’un procede de depistage |
CN104356236B (zh) | 2005-07-01 | 2020-07-03 | E.R.施贵宝&圣斯有限责任公司 | 抗程序性死亡配体1(pd-l1)的人单克隆抗体 |
JP5588175B2 (ja) | 2006-11-07 | 2014-09-10 | メルク・シャープ・アンド・ドーム・コーポレーション | Pcsk9のアンタゴニスト |
CA2680832A1 (fr) | 2007-03-27 | 2008-10-02 | Merck & Co., Inc. | Procede de detection de pcsk9 secretee, autogeneree |
AR070315A1 (es) | 2008-02-07 | 2010-03-31 | Merck & Co Inc | Anticuerpos 1b20 antagonistas de pcsk9 |
AR070316A1 (es) | 2008-02-07 | 2010-03-31 | Merck & Co Inc | Antagonistas de pcsk9 (proproteina subtilisina-kexina tipo 9) |
US8748115B2 (en) | 2008-12-12 | 2014-06-10 | Merck Sharp & Dohme Corp. | PCSK9 immunoassay |
JP2013509191A (ja) | 2009-10-30 | 2013-03-14 | メルク・シャープ・エンド・ドーム・コーポレイション | Ax1およびax189pcsk9アンタゴニストおよびバリアント |
WO2011053783A2 (fr) | 2009-10-30 | 2011-05-05 | Merck Sharp & Dohme Corp. | Antagonistes et variants ax213 et ax132 pcsk9 |
HUE059406T2 (hu) * | 2011-10-17 | 2022-11-28 | Io Biotech Aps | PD-L1 alapú immunterápia |
JP6389166B2 (ja) | 2012-05-07 | 2018-09-12 | トラスティーズ・オブ・ダートマス・カレッジ | 抗b7−h6抗体、融合タンパク質、及びこれらを使用する方法 |
CN109641936B (zh) * | 2016-06-21 | 2023-11-28 | Io生物技术公司 | 用于癌症疫苗中的pdl1肽 |
GB2605925B (en) | 2016-12-23 | 2023-02-22 | Harvard College | Gene editing of PCSK9 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0959907A4 (fr) * | 1996-07-24 | 2002-01-09 | Univ Maryland | Promoteur du gene de butyrophiline et utilisations de ce promoteur |
JPH1175859A (ja) * | 1997-09-08 | 1999-03-23 | R P R Jienseru Kk | アポト−シス関連遺伝子発現性のウイルスベクター系 |
WO1999042470A1 (fr) * | 1998-02-18 | 1999-08-26 | Genetics Institute, Inc. | Proteines secretees et polynucleotides codant lesdites proteines |
WO2001021631A2 (fr) * | 1999-09-20 | 2001-03-29 | Millennium Pharmaceuticals, Inc. | Proteines secretees et leurs utilisations |
-
2000
- 2000-11-01 JP JP2001537465A patent/JP2003513662A/ja not_active Withdrawn
- 2000-11-01 EP EP00976752A patent/EP1230360A4/fr not_active Withdrawn
- 2000-11-01 AU AU14487/01A patent/AU1448701A/en not_active Abandoned
- 2000-11-01 CA CA002389722A patent/CA2389722A1/fr not_active Abandoned
- 2000-11-01 WO PCT/US2000/030039 patent/WO2001034768A2/fr not_active Application Discontinuation
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8460927B2 (en) | 1999-11-30 | 2013-06-11 | Mayo Foundation For Medical Education And Research | B7-H1 antibodies and method of use |
US8981063B2 (en) | 1999-11-30 | 2015-03-17 | Mayo Foundation For Medical Education And Research | B7-H1 Antibodies |
US9062112B2 (en) | 1999-11-30 | 2015-06-23 | Mayo Foundation For Medical Education And Research | B7-H1, a novel immunoregulatory molecule |
US8747833B2 (en) | 2004-10-06 | 2014-06-10 | Mayo Foundation For Medical Education And Research | B7-H1 and methods of diagnosis, prognosis, and treatment of cancer |
US9803015B2 (en) | 2004-10-06 | 2017-10-31 | Mayo Foundation For Medical Education And Research | Costimulatory B7-H1 in renal cell carcinoma patients: indicator of tumor aggressiveness and potential therapeutic target |
US11242387B2 (en) | 2004-10-06 | 2022-02-08 | Mayo Foundation For Medical Education And Research | Costimulatory B7-H1 in renal cell carcinoma patients: indicator of tumor aggressiveness and potential therapeutic target |
US11939378B2 (en) | 2004-10-06 | 2024-03-26 | Mayo Foundation For Medical Education And Research | Costimulatory B7-H1 in renal cell carcinoma patients: indicator of tumor aggressiveness and potential therapeutic target |
Also Published As
Publication number | Publication date |
---|---|
WO2001034768A3 (fr) | 2002-01-24 |
EP1230360A4 (fr) | 2003-04-02 |
WO2001034768A2 (fr) | 2001-05-17 |
JP2003513662A (ja) | 2003-04-15 |
EP1230360A2 (fr) | 2002-08-14 |
AU1448701A (en) | 2001-06-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |